BIDMC 2011 Surgery Research 090612 NP Edits.Indd
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Annual Report January–December 2011 From the Chairman This issue of our Annual Research Report celebrates the tradition of clinical innovation carried on by the Department of Surgery at Beth Israel Deaconess Medical Center since its inception with the Harvard Fifth Surgical Service more than 150 years ago. Opportunities for innovation lie at the interfaces of disciplines — where individuals with diverse viewpoints communicate, examine problems through prisms that reflect very different perspectives, and share distinct ideas from highly disparate fields. This is what germinates new solutions to what were previously perceived as intractable clinical problems. The broad scope of the clinical and fundamental investigations summarized in this report highlight the qualities that are at the core of our department — our desire to nurture intellectual diversity, embrace individual freedom, encourage flexibility, and promote spontaneity and originality. We foster and celebrate these qualities because imaginative and inventive surgeons and investigators, students, residents, and fellows who are given the Elliot L. Chaikof, MD, PhD opportunity to work in diverse collaborations and teams have always been Johnson and Johnson central to the creation of new pathways leading to therapeutic breakthroughs. Professor of Surgery It is the inspiration and ingenuity of our academic community that contribute to the arena of ideas, which has always distinguished surgery at Beth Israel Chairman, Deaconess Medical Center and Harvard medicine. Department of Surgery This report is but a snapshot of the environment and activities within our Surgeon-in-Chief department and its highly interdisciplinary collaborations in the medical, biological, chemical, mathematical, computational, and engineering sciences. As the pace of these scientific and technological advances accelerates, we have many meaningful opportunities to advance the care of our patients in every clinical discipline of surgery. As you will read in this report, our department has a robust research enter- prise with nearly $20 million dollars in funding and 40 NIH grants, as well as some 400 publications generated by our faculty and students. The impres- sive work within our department continues to attract the brightest young women and men, who perform cutting-edge science that crosses boundaries. The individuals whose research is highlighted in this report represent the very best of our department and the medical center. One and all, they are dedicated to fulfilling our mission — of serving our communities, improving health through innovation and discovery, and preparing future leaders in American surgery. “We need to cut passages between shafts we have already dug instead of merely digging the same old shafts deeper and deeper.” Stringfellow Barr (1897–1982), author and educator Department of Surgery Research Annual Report 2011 | i ii | Beth Israel Deaconess Medical Center Overview of Surgical Research ................................................1 Table of Contents Division of Acute Care Surgery .............................................. 35 Carl J. Hauser, MD .................................................................. 37 Wolfgang Junger, PhD .............................................................. 39 Teresa Sanchez, PhD ................................................................. 43 Division of Cardiac Surgery .................................................. 47 Kamal R. Khabbaz, MD Robert C. Hagberg, MD David Liu, MD ........................................................................ 49 Sidney Levitsky, MD James D. McCully, PhD ............................................................. 57 Division of Colon and Rectal Surgery ..................................... 63 Deborah A. Nagle, MD Vitaliy Y. Poylin, MD Jeanne Quinn, NP Kristin Messer, RN ................................................................... 65 Division of General Surgery .................................................. 71 George L. Blackburn, MD, PhD Jin-Rong Zhou, PhD ................................................................ 75 Mark P. Callery, MD, FACS Tara S. Kent, MD Charles M. Vollmer, Jr. MD, FACS ............................................... 89 Rosemary B. Duda, MD, MPH .................................................... 95 Susan J. Hagen, PhD ................................................................ 97 Per-Olof Hasselgren, MD, PhD ................................................... 103 Daniel B. Jones, MD, MS, FACS .................................................. 107 Ranjna Sharma, MD ............................................................... 115 Division of Ophthalmology ................................................ 117 Jorge G. Arroyo, MD, MPH ....................................................... 119 Division of Plastic and Reconstructive Surgery ...................... 121 Department of Surgery Research Annual Report 2011 | iii Table of Contents Division of Podiatry ........................................................... 145 Aristidis Veves, MD, DSc .......................................................... 147 Division of Surgical Oncology ............................................. 153 Jennifer Tseng, MD, MPH ........................................................ 155 Division of Transplantation, Transplant Institute ................... 161 Amy R. Evenson, MD .............................................................. 165 Douglas W. Hanto, MD, PhD ..................................................... 167 Maria Koulmanda, MSc, PhD .................................................... 173 Dieder A. Mandelbrot, MD ....................................................... 177 Leo E. Otterbein, PhD ............................................................. 179 Martha Pavlakis, MD ............................................................... 183 Simon C. Robson, MD, PhD, FRCP ............................................. 185 James R. Rodrigue, PhD ............................................................ 189 Terry B. Strom, MD ................................................................197 Laurence A. Turka, MD ...........................................................201 M. Todd Valerius, PhD ............................................................205 Barbara Wegiel, PhD ...............................................................209 Division of Urology ........................................................... 213 Mohammed Simo Arredouani, PhD .............................................. 215 William C. DeWolf, MD W. Mike Schopperle, PhD ......................................................... 219 Martin Sanda, MD .................................................................223 Andrew A. Wagner, MD ...........................................................229 iv | Beth Israel Deaconess Medical Center Table of Contents Division of Vascular and Endovascular Surgery ..................... 233 Elliot L. Chaikof, MD, PhD ......................................................235 Christiane Ferran, MD, PhD....................................................... 241 Elzbieta Kaczmarek, PhD ..........................................................251 Frank W. LoGerfo, MD ............................................................255 Marc L. Schermerhorn, MD ...................................................... 271 Department of Surgery Research Annual Report 2011 | v vi | Beth Israel Deaconess Medical Center Overview of Surgical Research–2011 Overview of Introduction Surgical Research In addition to delivering outstanding patient care, research (basic, clinical, and translational) constitutes one of the cornerstones and missions of the Department of Surgery. Research programs in Surgery at Beth Israel Deaconess Medical Center (BIDMC) include Cancer Biology, Inflammation, Development, Vascular Biology, Cardiothoracic research, Transplantation- Immunology, Obesity-Nutrition-Metabolism, Wound Healing, Epithelial and Endothelial Biology, Bioengineering, and Clinical Outcomes. The Office for Surgical Research provides an administrative infrastructure to facilitate research in the Department of Surgery. Surgical Research is headed by Per-Olof Hasselgren, MD, PhD, who is Vice Chairman for Research in Surgery at Beth Israel Deaconess Medical Center (BIDMC) and the George H.A. Clowes Jr. Professor of Surgery at Harvard Medical School. Susan J. Hagen, PhD, who is Associate Vice-Chair for Research in Surgery and Associate Professor of Surgery at Harvard Medical School, assists with the management of Surgical Research. Surgical Research activities are supported by an administrative pool, with Rachel St. Fort as the former Administrative Supervisor and Molly Jay as the Administrative Assistant. Surgical Research has the following responsibilities: 1) Pre-award review and approval of all grant submissions in the Department of Surgery. This includes assisting in the process of submission of grant applications (collaborative or T32 grant applications) and interaction with the BIDMC Office of Sponsored Programs; 2) Management of research space, including laboratory and office space. For this, the allocation of research space within the department is overseen, shared tissue culture facilities are maintained, and the department is represented at various institutional committees and subcommittees dealing with research space at the BIDMC; 3) Organizing research seminars and other departmental research functions; 4) Tracking academic benchmarks