R ANNUAL ANFA R C EP O R T
020 2019/2
CANFAR ANNUAL 2 REPORT 2019/2020
OUR MISSION
HIV is now a preventable infection, yet the number of new cases only continues to climb with an estimated 63,050 people living with HIV in Canada. It’s estimated that six people newly acquire HIV each day - that’s nearly one person affected every four hours.
The Canadian Foundation for AIDS Research (CANFAR) aims to end Canada’s HIV epidemic by leading national strategies to increase prevention, testing and linkage to care and to end HIV stigma. Fueled by fundraising, CANFAR supports research, builds awareness and cultivates partnerships. CANFAR ANNUAL REPORT 2019/2020 3
A MESSAGE FROM OUR BOARD CHAIR Dear CANFAR community, As we mark the start of the of new infections continues to to sharply increase much- happen without the support COVID-19 pandemic, we must increase year over year in our needed testing (the availability of our dedicated employees also remember that other nation, and in many most-at- of anonymous home testing and our engaged Board great pandemic of our time risk populations. Addressing has been a proven tool in of Directors and Scientific that has claimed more than this reality is now central to driving HIV numbers down in Advisory Committee, working 36 million lives – HIV and CANFAR’s strategy and focus. other jurisdictions around the together with many supporters AIDS. Efforts by the Canadian world). Work also continues and partners. I extend my Foundation for AIDS Research That strategy is straight-forward: to ensure that Canadians sincere thanks to the team for (CANFAR) to create innovative 1. Greatly improve testing everywhere have access to their countless contributions. programming to support its to reach the 14 percent PrEP or PEP, according to mission of eradicating HIV/ of Canadians – often their needs and means. Most importantly, we give AIDS in Canada have not members of marginalised our heartfelt thanks to slowed down. communities – who are HIV Over the past year, CANFAR our community of donors. positive and do not know it. has grown its footprint Your ongoing support and In fact, there is encouraging nationally through several generosity allow us to work news as we remain on target 2. For those who test awareness campaigns and towards our vision of ending to lower new infection rates positive, ensure they programs, essential measures the HIV epidemic in Canada across Canada by up to 80 can access the best to ensuring the success of within five years. percent by 2025. possible care as quickly as our strategy. For example, possible, no matter where we reached more than If you haven’t already, please While CANFAR remains they live or who they are. 450,000 Canadian youth consider joining me to support committed to the research it 3. For those who test with HIV education initiatives. this movement to leave an has been funding for almost negative, but who may be By launching innovative AIDS-free world to future 35 years, its strategic focus vulnerable to HIV infection, campaigns and new generations. Simply put, that now is to put that research to provide access to pre- partnerships, we also initiated is our task. work to end the HIV pandemic exposure prophylactics conversations about HIV in this country. We have had (PrEP) or post-exposure stigma on the national stage many successes to date – prophylactics (PEP). that led to enhanced levels of HIV is now a widely treatable awareness and engagement infection and people with HIV To support this strategy, we in targeted communities. are living long and healthy have co-funded research lives. However, unlike other required for Health Canada’s Translating our vision of Andrew Pringle, CM developed nations where HIV imminent approval of self-test ending the HIV epidemic in Chair, is on the wane, the number kits in Canada, a key tool Canada into a reality cannot CANFAR Board of Directors CANFAR ANNUAL 4 REPORT 2019/2020
BOARD OF DIRECTORS Some of Canada’s foremost leaders in the financial, legal, and philanthropic sectors sit on CANFAR’s Board of Directors. The Board of Directors is responsible for establishing the mission, vision and direction of CANFAR, while representing the interests of the organization. CANFAR ANNUAL REPORT 2019/2020 5
ANDREW PRINGLE, CM TRISTAN MICHELA MARIE HENEIN PAUL NOBLE BOARD CHAIR Executive Vice President, Senior Partner, Henein Vice-President, Deputy General RPIA (RP Investment Advisors) CANDEAL Hutchison LLP Counsel, BMO Capital Market
CHRISTOPHER BUNTING DR. STANLEY READ, MD, PHD JONATHAN HICKS TONY PEDARI, CPA DEPUTY CHAIR Professors, Department of Communications Consultant Partner, Risk Assurance Paediatrics, University of Toronto Services, PwC PATTI MACNICOL ROBERT HOPPENHEIM VICE-CHAIR & TREASURER CASEY ANTOLAK Head of Brand, Strategy, JOHN PRATO Vice Principal, Administration, Vice President, Scotiabank Creative and Communications, Deputy Chair & Executive Upper Canada College Hoppenheim & Co. Managing Director, TD Securities WILLIAM FLANAGAN PATRICIA OLASKER President and Vice Chancellor of JEFFREY KROEKER REV. JEFF ROCK VICE-CHAIR & SECRETARY the University of Alberta Partner, Civis Law LLP Pastor, Metropolitan Community Partner, Davies Ward Phillip & Church of Toronto Vineberg LLP DR. MICHAEL GRANT, STEPHEN B. LEWIS PHD, MSC Chair, Stephen Lewis Foundation JAIME WATT CHARLES ARMSTRONG Chair, Scientific Advisory Executive Chairman, Navigator Ltd. Chair, Armstrong Fluid Committee, Professor of SYLVIA MANTELLA Technology Immunology, Associate Dean, Chief Marketing Officer, Mantella LEEANNE WELD KOSTOPOULOS BioMedical Sciences, Faculty of Corporation Sales Representative, Royal LePage JERONIMO DE MIGUEL Medicine, Memorial University of Real Estate Services Ltd. Johnston Brand Strategist Newfoundland NOTISHA MASSAQUOI & Daniel Division, Brokerage Consultant CANFAR ANNUAL 6 REPORT 2019/2020
SCIENTIFIC ADVISORY COMMITTEE
CANFAR funds Canadian HIV/AIDS researchers who are selected by the Scientific Advisory Committee (SAC), based on the excellence of their proposals. As a committee, the SAC are ultimately responsible for selecting the most significant research projects from the many applications that they receive. CANFAR ANNUAL REPORT 2019/2020 7
DR. MICHAEL GRANT, PhD DR. NORBERT GILMORE, DR. MONA LOUTFY, CHAIR Professor, Immunology, MD, PhD MD, MPH, FRCPC CANFAR STAFF Division of BioMedical Sciences, Professor, Medicine (Emeritus), Associate Professor, Faculty of Medicine, Memorial McGill University; Senior Department of Medicine, ALEX FILIATRAULT University of Newfoundland Physician, McGill University University of Toronto; Scientist, Chief Executive Officer Health Centre Women’s College Research DR. STANLEY READ, Institute; Staff Physician, MD, PhD, FRCPC DR. DANIEL GRACE, MA, PhD Women’s College Hospital JOAN SMART CO-CHAIR Professor of Pediatrics, Canada Research Chair in Senior Manager of University of Toronto, The Hospital Sexual and Gender Minority DR. PAUL SANDSTROM, PhD Finance and Operations for Sick Children; Consultant Health; Assistant Professor, Dalla Director, National HIV & HIV/AIDS Family Centered Care Lana School of Public Health, Retrovirology Laboratories, Program Division for Infectious University of Toronto; JC Wilt Infectious Diseases ROXANNE MA Diseases, Department of Research Centre, PHAC Senior Manager Pediatrics, University of Toronto DR. TREVOR HART, PhD, C. PSYCH of National Youth DR. LISA BARRETT, Ontario HIV Treatment Network DR. CÉCILE TREMBLAY, Awareness Programs MD, PhD, FRCPC Applied HIV Research Chair in MD, FRCPC Assistant Professor, Gay and Bisexual Men’s Health, Professeure, Titulaire de Dalhousie University Professor and Director, HIV la Chaire de Recherche LOGAN THAYALAN Prevention Lab, Department of Translationelle en VIH Pfizer/ Senior Manager of DR. ALAN COCHRANE, PhD Psychology, Ryerson University Universite de Montreal, Events and Stewardship Professor, Department of Department de Microbiologie, Molecular Genetics, University of DR. MICHAEL HAWKES, Immunologie et Infectiologie, Toronto MD, PhD Universite de Montreal JESSICA GAGNON Assistant Professor, Department Manager of Graphic DR. EVAN COLLINS, of Pediatrics, University of Alberta DR. SHARON WALMSLEY, MD, FRCPC MD, MSC, FRCPC Design and Marketing Professor, Department of DR. CHEN LIANG, PhD Professor of Medicine, University Psychiatry, University of Toronto; Professor, Department of of Toronto; Director of Clinical Psychiatrist Medicine, McGill University; Research, Immunodeficiency CANDICE ZHANG Interim Director, McGill AIDS Clinic, Toronto Hospital, UHN; Assistant Manager of DR. HÉLÈNE CÔTÉ, PhD Centre, Lady Davis Institute, Jewish Senior Scientist, Toronto Hospital Finance and Operations Professor, Department of General Hospital, McGill University Research Institute; Co-Chair of the Pathology & Laboratory Medicine, CIHR-Canadian HIV Trials Network University of British Columbia CANFAR ANNUAL 8 REPORT 2019/2020
CURRENT RESEARCH ON-GOING RESEARCH Title: 2019 CANFAR/CTN Postdoctoral Fellow Funding: $50,000 CANFAR Grant Lead: Dr. Elisabeth McClymont Time Frame: On-going since 1992 Description: An undergraduate course, “The Global HIV/AIDS Epidemic”, enthralled Elisabeth with the multifaceted nature of the HIV epidemic. During her time as a postdoctoral fellow with the CTN, Dr. McClymont will be investigating cytomegalovirus (CMV) transmission among women living with HIV and their children. CMV is one of the most common viral infections, present in an estimated 40-100% of people worldwide. In those with compromised immune systems (uncontrolled HIV, leukemia, newborns), the virus can cause health complications including gastrointestinal infections and neurological disorders. Dr. MClymont explained, “The earlier stage of vaccine development for CMV brings different and interesting questions of how to optimize a vaccine to best suit people living with and without HIV. Understanding the natural CMV transmission dynamics in women living with HIV will help inform that optimal vaccine design.” CANFAR ANNUAL REPORT 2019/2020 9
Title: ENGAGE: A Canadian Research and Intervention team on Gay and Bisexual Men’s Sexual Health 2020 CAHR-CANFAR Lead: Dr. Trevor Hart EXCELLENCE IN RESEARCH Time Frame: 2016 – 2021 AWARDS Description: Engage is a five-year multi-site Canadian The CAHR-CANFAR Excellence in Research collaboration between researchers and community- Awards are bestowed annually to mid-career based organizations on HIV and sexual health researchers who while at the prime of their careers among gay men in Canada. Its three primary aims have achieved a track record of excellence and are to provide research evidence to inform HIV and demonstrated a commitment to improving the lives STBBI prevention initiatives for Canadian gbMSM, of those living with HIV with or at risk. Awarded and integrate community engagement into all stages since 2017, the recipients are honoured each year of the project to enhance community-researcher at the opening ceremony of the CAHR Conference collaboration and bidirectional knowledge exchange. to highlight the achievements of investigators in all pillars of HIV research. Title: Pan-Canadian PrEP Cohort Study – grants Those recognized for 2020: from CIHR, CANFAR, REACH, OHTN Basic Sciences: DR. LENA SERGHIDES, PHD Lead: Dr. Darrell Tan Toronto General Hospital Research Institute
Time Frame: 2018 – 2022 Clinical Sciences: DR. PATRICK O’BYRNE, RN-EC PHD University of Ottawa, Faculty of Health Sciences Description: PrEP is intended to prevent HIV infections, and possibly reduce STIs (testing Epidemiology-Public Health: DR. CLAIRE KENDALL patients often may lead to earlier treatment and less Bruyere Research Institute, C.T. Lamont Primary transmission). However, some stakeholders remain Health Care Research Centre skeptical of PrEP, concerned that poor adherence Social Sciences: DR. ROBERT LORWAY could drive the emergence of drug-resistant HIV, that Canada Research Chair, University of Manitoba, unbridled risk-taking may fuel epidemics of sexually Centre for Global Public Health Department of transmitted infections (STI’s), and that stigma could Community Health Services curtail clinically indicated use. What balance is being achieved between these undesirable and desirable Community-Based Research: DR. JOHN KIM outcomes? Which users have worse outcomes, and National Laboratory for HIV Reference Services, how could they be better supported? JC Wilt Center for Infectious Diseases, PHAC CANFAR ANNUAL 10 REPORT 2019/2020
CURRENT RESEARCH OVERVIEW OF CANFAR RESEARCH GRANTS Title: A Study to Evaluate the Accuracy, Usability, 1. Evaluate the INSTI HIV Self-Test performance and Acceptance of a Blood-Based HIV Self-Test compared with laboratory reference testing; Performed by Observed Intended Users in Canada 2. Document if intended users could follow the steps Funding: REACH Nexus (previously “CIHR Centre for to use the HIV self-test device; and REACH”) and CANFAR ($150,000) 3. Determine if intended users could successfully Time Frame: August 2019 – March 2020 interpret mock positive, negative and invalid results. Description: This REACH Nexus research led to the REACH submitted the study results to Health Nov. 3, 2020 approval of Canada’s first HIV self-test, Canada for the INSTI HIV Self Test licensure, leading the INSTI HIV Self-Test. to its early November 2020 approval. HIV self-testing is a pragmatic solution that has We are confident that adding an approved, and now the potential to increase the access, uptake and available to consumers, HIV self-test to the Canadian HIV frequency of HIV testing and to more effectively testing landscape will significantly increase HIV testing reach people who are undiagnosed, especially in rates. Having a blood-based HIV self-test approved key populations. The objectives of this REACH-led in Canada offers an accurate, acceptable and simple study, intended for submission to Health Canada for alternative to facility-based HIV testing, particularly while regulatory approval purposes, were to: testing access is impacted by COVID-19 restrictions. CANFAR ANNUAL REPORT 2019/2020 11
Title: Manitoba Pathways to Care: Building the Innovative testing and connections to care strategies Foundation for Innovations in HIV-STBBI Testing, for rural and remote communities are in demand. Linkage and Care in Rural and Remote Areas of This project brings Indigenous and non-Indigenous Manitoba. partners together in a two-eyed seeing way to develop a peer navigator program, an event-based Funding: CANFAR Strategic Initiatives ($100,000) testing toolkit, and to introduce innovative testing and REACH Nexus methodologies to support increased testing and Time Frame: November 1, 2019 – ongoing connections to care for rural, remote and First Nations communities in Manitoba. Description: This project, led by Nine Circles Community Health Centre and the Manitoba Harm This project led to the development of the Community Reduction Network, is aiming to build the foundation Event-Based Testing Toolkit, now available to download for innovations in HIV and STBBIs testing, connections on the Manitoba Harm Reduction Network’s website. and care in rural and remote areas of Manitoba. This Through this project, the leads are also building is a developmental project that’s using a number of important relationships with the Manitoba First Nations promising emerging practices. AIDS Awareness Working Group. CANFAR ANNUAL 12 REPORT 2019/2020
CANFAR has been leading Canada’s NATIONAL national youth HIV awareness program for more than 27 years. We understand that the needs of young people are YOUTH constantly evolving. This year, CANFAR focused on the digitization of our community-based resources and underwent a AWARENESS major update to CANFAR’s website to increase the accessibility of our existing HIV resources for youth. With the COVID-19 pandemic, we had to make PROGRAMS the difficult decision to postpone some of our in- person program activities planned for the spring of 2020, including the third annual high school tour in partnership with SExT: Sex Education by Theatre.
REACHING STREET-INVOLVED YOUTH In Canada, street-involved youth have HIV rates three times that of the Canadian adult population and are more likely to engage in substance use, including injection drugs. 1 CANFAR worked with our community partners in Manitoba, Alberta and Newfoundland and Labrador to deliver online HIV and harm reduction resources for street-involved youth across Canada. The changes were launched on CANFAR’s website in April of 2020.
1 Renna, Cris (Cristine). “Street-Involved Youth in Canada.” CATIE, 2012, www.catie.ca/en/pif/spring-2012/street-involved-youth-canada. CANFAR ANNUAL REPORT 2019/2020 13
The above features the redistribution of the BOOM website content to make different topics easier to access and navigate.
BOOM website: additional content on substance use and mental health coping.
BOOM Website: updated imagery for sexual health. REACHING YOUNG MEN WHO HAVE SEX WITH MEN Following CANFAR’s feedback survey on BOOM in early 2019, in which respondents gave the resource overwhelmingly positive feedback, CANFAR further expanded the content by adding information on substance use for gay, bisexual and other men who have sex with men, and redistributed the content as well as enhanced the interactivity and design of the BOOM website with new images to make it easier to access and navigate, and more engaging and visually appealing for youth. These changes were launched in an update on the CANFAR website in April of 2020. CANFAR’s partnership with the Community- Based Research Centre (CBRC) also focused on increasing queer men’s sexual health literacy and leadership through a national update of the Totally Outright training program. A brand-new website for Totally Outright is being developed to increase the program’s visibility and accessibility nationally. CANFAR ANNUAL 14 REPORT 2019/2020
EXPLORING DISTANCE HIGHLIGHTS OF THE COLLECTED RESPONSES FROM OVER 1 YOUTH BETWEEN THE AGES OF 12 AND 2 LIVING IN CANADA... LEARNING AND INNOVATION IN A TIME OF COVID-19 1 2 In February of 2020, CANFAR was in the process of OUT ARE N ONO A OU RELAT ON P OUT ARE N NON ONO A OU RELAT ON P planning a third annual school tour with community (OPEN, CASUAL AND/OR MULTIPLE CASUAL RELATIONSHIPS) partner, SExT: Sex Education by Theatre. While the pandemic caused us to postpone these efforts, OF T E OUT N NON ONO A OU E UAL RELAT ON P ONL in March of 2020, CANFAR began exploring a new partnership with Connected North, a digital education program by Cisco and TakingITGlobal that connects LANDSCAPE OF YOUTH HIV Indigenous students in northern Canada with 1 educators, mentors and speakers across the country AWARENESS IN CANADA OUT U E CON O E ER T E to deliver high-definition, live educational sessions In December of 2019, CANFAR conducted a second using Cisco technologies. Currently, Connected national landscape assessment of youth’s sexual North does not offer any sessions on sexual health, health and HIV knowledge, experiences, attitudes, presenting CANFAR with a unique opportunity to and needs through an online survey. The survey partner with SExT to lead the sexual health and HIV 10 collected responses from over 471 youth between the programming for Indigenous youth in remote areas of OUT CON TENTL TRON L A REE OR A REE T T E FOLLO N ages of 12 and 25 living in Canada. The data will be Canada’s North in creative and engaging ways. fully analyzed this summer and will be summarized I o ld s are tensils it so eone o as HIV As CANFAR and SExT explore this partnership and in a final report that will be published on CANFAR’s pilot opportunity, we released our impact video from website and shared with our community partners to I o ld date so eone it HIV CANFAR’s 2019 Tour in partnership with SExT. increase community knowledge and capacity. I o ld iss a e o t it so eone o as HIV SPONSORS ACKNOWLEDGEMENT Thank you to CANFAR’s Program Sponsors: the Slaight Family Foundation, Canada Life and MAC AIDS Fund, for which this program would not be possible without their generous support. HIGHLIGHTS OF THE COLLECTED RESPONSES FROM OVER 1 YOUTH BETWEEN THE AGES OF 12 AND 2 LIVING IN CANADA... 1 2 OUT ARE N ONO A OU RELAT ON P OUT ARE N NON ONO A OU RELAT ON P (OPEN, CASUAL AND/OR MULTIPLE CASUAL RELATIONSHIPS)
OF T E OUT N NON ONO A OU E UAL RELAT ON P ONL 1 OUT U E CON O E ER T E 10 OUT CON TENTL TRON L A REE OR A REE T T E FOLLO N I o ld s are tensils it so eone o as HIV