Management of Neonates Born at ≤34 6/7 Weeks' Gestation with Suspected Or Proven Early-Onset Bacterial Sepsis Karen M
CLINICAL REPORT Guidance for the Clinician in Rendering Pediatric Care ≤ ’ Management of Neonates Born at 34 Karen M. Puopolo, MD, PhD, FAAP, a, b William E. Benitz, MD, FAAP, c Theoklis E. Zaoutis, MD, MSCE, FAAP, a, d 6/7COMMITTEE ONWeeks FETUS AND NEWBORN, GestationCOMMITTEE ON INFECTIOUS DISEASES With Suspected or Proven Early-Onset Bacterial Sepsis Early-onset sepsis (EOS) remains a serious and often fatal illness among abstract infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm infants with very low birth weight are treated empirically with antibiotics for risk of EOS, often for prolonged aDepartment of Pediatrics, Perelman School of Medicine, University periods, in the absence of a culture-confirmed infection. Retrospective of Pennsylvania, Philadelphia, Pennsylvania; bChildren’s Hospital of studies have revealed that antibiotic exposures after birth are associated Philadelphia, and dRoberts Center for Pediatric Research, Philadelphia, Pennsylvania; and cDivision of Neonatal and Developmental Medicine, with multiple subsequent poor outcomes among preterm infants, making the Department of Pediatrics, School of Medicine, Stanford University, Palo risk/benefit balance of these antibiotic treatments uncertain. Gestational Alto, California age is the strongest single predictor of EOS, and the majority of preterm This document is copyrighted and is property of the American Academy of Pediatrics and its Board of Directors. All authors have births occur in the setting of other factors associated with risk of EOS, filed conflict of interest statements with the American Academy of Pediatrics. Any conflicts have been resolved through a process making it difficult to apply risk stratification strategies to preterm infants.
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