DOCSLIB.ORG

Patent Application Publication Oo) Pub. No.: US 2014/0336159 Al Clarke Et Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

US 20140336159A1 (19) United States (12) Patent Application Publication oo) Pub. No.: US 2014/0336159 Al Clarke et al. (43) Pub. Date: Nov. 13,2014 (54) METHODS FOR TREATING AND 61/605,013, filed on Feb. 29, 2012, provisional appli­ DIAGNOSING RESPIRATORY TRACT cation No. 61/607,936, filed on Mar. 7, 2012, provi­ INFECTIONS sional application No. 61/648,960, filed on May 18, 2012, provisional application No. 61/648,822, filed on (71) Applicant: PULMATRIX, INC., Lexington, MA May 18, 2012. (US) Publication Classification (72) Inventors: Robert William Clarke, Medfield, MA (US); David L. Hava, Natick, MA (US); (51) Int. Cl. John P. Hanrahan, West Roxbury, MA A61K31/19 (2006.01) (US); Wesley Hugh Dehaan, A61K9/00 (2006.01) Chelmsford, MA (US); Paulette Wright A61K31/56 (2006.01) Andreotta, Charlton, MA (US); Stephen A61K4S/06 (2006.01) P. Arold, Billerica, MA (US); Jennifer (52) U.S. Cl. Kenyon Saunders, Boston, MA (US) CPC ................. A 61K 31/19 (2013.01); A 61K 45/06 (2013.01); A 61K 9/0078 (2013.01); A61K (21) Appl. No.: 14/350,235 9/0075 (2013.01); A 61K 31/56 (2013.01) USPC ............................................. 514/171; 514/557 (22) PCT Filed: Oct. 5, 2012 (57) ABSTRACT (86) PCT No.: PCT/US2012/059022 Described are methods of preventing, treating and diagnosing § 371 (c)(1), of a subject having a condition, such as, an inflammation or (2), (4) Date: Apr. 7, 2014 infection of the respiratory tract. Methods of treatment and prevention include administration of effective amounts of Related U.S. Application Data calcium salt formulations to a subject. Methods of diagnosing (60) Provisional application No. 61/544,400, filed on Oct. include the use of biomarkers and optionally the use of kits 7, 2011, provisional application No. 61/550,081, filed that can detect biomarkers. Further described are methods for on Oct. 21, 2011, provisional application No. 61/584, modulating an immune response that include the modulation 001, filed on Jan. 6, 2012, provisional application No. of Toll-like receptors. Patent Application Publication Nov. 13, 2014 Sheet I of 24 US 2014/0336159 Al FIGURE IA Calcium ion dose Lung Dose mg/kg matching Predinicai Model MCC infection Inil ammat Idri Patent Application Publication Nov. 13, 2014 Sheet 2 of 24 US 2014/0336159 Al FIGURE IB Lung Dose, Lung Mass Matching Precfinical Model Patent Application Publication Nov. 13, 2014 Sheet 3 of 24 US 2014/0336159 Al FIGURE IC 1I as £ S- '"iRS O CS Lung Dose E Lung Area hatching Predsnica! Model Patent Application Publication Nov. 13, 2014 Sheet 4 of 24 US 2014/0336159 Al A 7% HS FIGURE 2 Form. I (30) Form. I (30): 30pg/cm2 Form. I (10): 10|ig/cm2 Form. I (10) 30 40 SO 60 Tim© (min) Form. If (30) Form. If (30): 30pg/cm Form. I! (10): iOpg/cm WaCI DP Form. CO 10 18 30 46 60 76 90 T im e (m in ) Patent Application Publication Nov. 13, 2014 Sheet 5 of 24 US 2014/0336159 Al FIGURE 3 2 § - - 7% HS 1§» A Vehide ■#> Formulation Il I mg/kg V Formulation I!. 0 5 mg/kg ■ Formulation II. 0.25 mg/kg §J T* 40 80 80 & Vehicle <#> Formulation li, 1 mg/kg. 2hr Dur V Formulation II. 0 5 mg/kg, 2hr Dur O 7% Saline (% of Baseline) (% of Baseline) Mucociliary Clearance Mucociliary Clearance -I 280 Tsme (m in) Patent Application Publication Nov. 13, 2014 Sheet 6 of 24 US 2014/0336159 Al FIGURE 4 Mean Central Lung MCC No Treatment Controf Form. !I 22mg Patent Application Publication Nov. 13, 2014 Sheet 7 of 24 US 2014/0336159 Al FIGURES ILB B ILS 2900© 260-j 18000 1800©I 200- j $Q m 150- £ "3s 4000- 0 . 100 2000 50- 0j 0- A o4' A o%' I-------------!!-------------S i______ il------- —S 5.5mg 11mg 5.5mg 110¾ GM-CSF ILIP 800- 50O-| 400I SO©-** I 120-r E OS Ss 80- a CL 40- ©■ 5.5mg 11 mg S.Smg 111¾¾ Patent Application Publication Nov. 13, 2014 Sheet 8 of 24 US 2014/0336159 Al FIGURE 6 A Total Cells/g Sputum I DG D2 DO D2 S.S mg 11 mg B Total Neutrophils/g Sputum «53 E 5 D 3 4' Q, CO as 3- W © 2 U O ^ 1 » 3 Z DO D2 DO D2 S.S mg 11 m g Patent Application Publication Nov. 13, 2014 Sheet 9 of 24 US 2014/0336159 Al FIGURE 40 I Mean Change in % Eosinophils fn=6) I 50 Mean 15.8 I OO 5? Mean 6,7 .£ 111 Baseline Form. V Placebo Patent Application Publication Nov. 13,2014 Sheet 10 of 24 US 2014/0336159 Al FIGURE 8 A. K, pneumoniae S. pneumoniae xrX£ 100- 25 80- LL O 40- -L W / O / $ 0 "> o—¢5—o~—~-O T- 0 m 120 ISO 240 0 60 120 180 240 Time (mini Time (min) c. D, P. aeruginosa S. aureus 0 60 1 20180 240 0 60 120 180 240 Time {mm} Time (mm} Patent Application Publication Nov. 13,2014 Sheet 11 of 24 US 2014/0336159 Al FIGURE 9 InfSuema ,A 3-» SC 2- o Na 1X 1QX Ca dose Rhinovirus -®- Sal:ne -O- 0.12M CaCb in saline -Si- 0 STofvI CaCi2 in saiine -Q- I 2M CaCI2 m saline M 120 180 Time (min) Patent Application Publication Nov. 13,2014 Sheet 12 of 24 US 2014/0336159 Al FIGURE 10 80' Saline 80' 2X 1:1.3, Form. V -J 70' 2X 8:1 E SO- CS C SO- 8x81, Form.! 40- Q. j.. 30' at "S3 20- 10- 0- 120 240 380 Time (min) Patent Application Publication Nov. 13, 2014 Sheet 13 of 24 US 2014/0336159 Al FIGURE 11 p<C-<JS S- 5" E S S u 3“ SS 2- O »1 I- T ~ T * ~ T ~ Mt Form. V !.0 0.01 Zartatrevir Zanamtvir * Form. V B PatentApplication Publication Nov. 13, 2014 Sheet 14 of 24 US 2014/0336159 Al FIGURE 12 A Infection model Rhinovirus P. aeruginosa: LPS I 0"» p-'0 05 7.5 «* p<0.01 t................ I I L I 0 8 - 5 .0 “ 0 6 - 0 4- 2 .5 “ 0 2 - 0 0- 0.CT & 4! E .£ ‘u E U S 3 3 o Q) o & u. w-! Inflammation model Tobacco smoke Ozone 2.5- I 1.5 ” 2.0 - 1.5- 1.0 - 1 , 0 ” 0.5 - 0.5- Neutrophils IxieSf IxieSf Neutrophils 03 (xlQ5) Neutrophils 0. 0 - 0.0 J — ^L™^iW,T."nnrr,rrj f I E 3 Li* E 3 S & O PatentApplication Publication Nov. 13, 2014 Sheet 15 of 24 US 2014/0336159 Al FIGURE 12C Ozone Exposed PatentApplicationPublication Nov. 13,2014 Sheet 16 of 24 US 2014/0336159 Al FIGURE 13 Upregulaled with Upregulated with Tobacco smoke Rhmovirus-Ib infection X"""" / ,/ / / s\reg / bsuU / CdOAKP- i SUgl CU "/SgCC x CdC Cdl ? Cxd (U T C /O d d a C d eV CM-SlfKC CxrUA C x d w O V d O u d OcSCdUWts b i d CxdS Him CxdlC5 Cf \ SLS \ IdxdS5 TUC - \ NV xV x V-""" '-SVsv^ vsW. -X x - .... Downregulated with Downregulated with Tobacco smoke Rhinovirus-Ib infection Adrbl Cxc r4 Proc Apinr CxcrS Pou2afl Bdnf Fasl Ppbp Gusb Bm p6 Hspbl Pri2c2 Hifla CSa IgfbpS Rgs3 Pmaipl Cd5 i!l6 T irl GprSl Serpinala Ccr6 KcnaS TIrS 5od2 CcrS Lefl TIrS Ccrll Lep Xcil CcrU N od CrntrnS Perl Crebl Pin PatentApplication Publication Nov. 13, 2014 Sheet 17 of 24 US 2014/0336159 Al FIGURE 14 Supplemental CaCI ifmM) 2000 JsP* Supplemental Cad ^fmIVS) Patent Application Publication Nov. 13,2014 Sheet 18 of 24 US 2014/0336159 Al FIGURE 15 A & SS KC E «3 JZ u 2 o u Se * ^ ' p <§> Supplemental CaCfg fmfV!} 60 H B IL-S 0! as E fS JZ U 4 0 -i TS O «5 Jj 20- Supplemental CaCtg fmtVf) TNFalpha Supplemental CaQg (raMj PatentApplication Publication Nov. 13, 2014 Sheet 19 of 24 US 2014/0336159 Al FIGURE 16 ENA78 GM-CSF 4.S- 4.0- 3 .S- 3.0- 2 5- 2. 0 - I 5- 1 C- 0.5- 0.0J ■ i c-* ■;>* .o* s?' #• 1 ngftnl LPS 1 ng.'mf LPS !VttP-2 (P-10 25-, Si 2 0 - f I SO- p-n* /Ct I u. S- Qj I ! I f .................I..................................... T * S ^ '-? ip I n^'nrsL LPS 1 ag/mi LPS NRfPt (R1P140) I ng/s«t LP S PatentApplication Publication Nov. 13, 2014 Sheet 20 of 24 US 2014/0336159 Al FIGURE 17 TNFa IL-8 {pgSrnl} IL-8 SuppSemental GaGi 2 JmMS B 2800- _ 2 0 0 0 - § , 1500- CL C9 1000- JtC ~ 500 - !----------- r 4? SuppismentaS CaC!? (miVI) PatentApplication Publication Nov. 13, 2014 Sheet 21 of 24 US 2014/0336159 Al FIGURE 18 A Calcium Chloride -I- Caicum Lactate 1500 - a Magnesmin Chloride --4- Sodium Chloride £5 1000 -< 500 ' SuppiementaS Salts (mM) # Caidum Chloride S Calcium Lactate a Magnesium Chloride -jS- Sodium Chloride Suppiementai Salts (mM) Patent Application Publication Nov. 13,2014 Sheet 22 of 24 US 2014/0336159 Al FIGURE 18 cont. C IL-S Calcium Chicnde ~m CaiQurr Lactate ■& MagnfsSiur Chlonde Sodiun Chionde a. 400 • Supplemental Salts (mM) D IL-6 CaiQLm Chionde ■m Ca!citm Lactate •4- Magnesium Chionde -*-■ sC'd'UTi Chlorde Supplemtntal Salts (mM) Patent Application Publication Nov. 13, 2014 Sheet 23 of 24 US 2014/0336159 Al FIGURE 19 KC TNFa KC (pgfml) KC Supplements* CaCI3 (mft*) Supplements! CaC3? t KC TNFa C 1000«, 300- v I 600- £ ^oo- 200- S A 0- HF- SS *5 NS> ❖ Supptewntsl CaCf2 {mNi) SuppteJiientat CaCij (snW) PatentApplication Publication Nov.
Recommended publications
  • Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report

    Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report

    Project No. TREN-05-FP6TR-S07.61320-518404-DRUID DRUID Driving under the Influence of Drugs, Alcohol and Medicines Integrated Project 1.6. Sustainable Development, Global Change and Ecosystem 1.6.2: Sustainable Surface Transport 6th Framework Programme Deliverable 4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Due date of deliverable: 21.07.2011 Actual submission date: 21.07.2011 Revision date: 21.07.2011 Start date of project: 15.10.2006 Duration: 48 months Organisation name of lead contractor for this deliverable: UVA Revision 0.0 Project co-funded by the European Commission within the Sixth Framework Programme (2002-2006) Dissemination Level PU Public PP Restricted to other programme participants (including the Commission x Services) RE Restricted to a group specified by the consortium (including the Commission Services) CO Confidential, only for members of the consortium (including the Commission Services) DRUID 6th Framework Programme Deliverable D.4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Page 1 of 243 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Authors Trinidad Gómez-Talegón, Inmaculada Fierro, M. Carmen Del Río, F. Javier Álvarez (UVa, University of Valladolid, Spain) Partners - Silvia Ravera, Susana Monteiro, Han de Gier (RUGPha, University of Groningen, the Netherlands) - Gertrude Van der Linden, Sara-Ann Legrand, Kristof Pil, Alain Verstraete (UGent, Ghent University, Belgium) - Michel Mallaret, Charles Mercier-Guyon, Isabelle Mercier-Guyon (UGren, University of Grenoble, Centre Regional de Pharmacovigilance, France) - Katerina Touliou (CERT-HIT, Centre for Research and Technology Hellas, Greece) - Michael Hei βing (BASt, Bundesanstalt für Straßenwesen, Germany).
  • (12) United States Patent (10) Patent No.: US 9,314.465 B2 Brew Et Al

    (12) United States Patent (10) Patent No.: US 9,314.465 B2 Brew Et Al

    US009314465B2 (12) United States Patent (10) Patent No.: US 9,314.465 B2 Brew et al. (45) Date of Patent: *Apr. 19, 2016 (54) DRUG COMBINATIONS AND USES IN 2008.0003280 A1 1/2008 Levine et al. ................. 424/456 TREATING A COUGHING CONDITION 2008/O176955 A1 7/2008 Hecket al. 2008, 0220078 A1 9, 2008 Morton et al. (71) Applicant: Infirst Healthcare Limited 2009, O136427 A1 5/2009 Croft et al. 2009, O220594 A1 9, 2009 Field (72) Inventors: John Brew, London (GB); Robin Mark 2012/O128738 A1 5, 2012 Brew et al. Bannister, London (GB) 2012fO252824 A1 10/2012 Brew et al. (73) Assignee: Infirst Healthcare Limited, London FOREIGN PATENT DOCUMENTS (GB) CN 1593451 3, 2005 CN 101024.014 A 8, 2007 (*) Notice: Subject to any disclaimer, the term of this CN 101112383 B 5, 2010 patent is extended or adjusted under 35 DE 4420708 A1 12, 1995 U.S.C. 154(b) by 0 days. EP 2050435 B1 4/2009 GB 2114001 A 8, 1983 This patent is Subject to a terminal dis GB 2284761 A 6, 1995 claimer. GB 2424.185 B 9, 2006 GB 2442828 A 4/2008 JP 62-249924 A 10, 1987 (21) Appl. No.: 14/287,014 JP H1O-316568 A 12/1998 JP 2001-518928 A 10, 2001 (22) Filed: May 24, 2014 JP 200219.3839. A T 2002 JP 2003-012514 A 1, 2003 (65) Prior Publication Data JP 20030552.58 A 2, 2003 JP 2003128549 A 5, 2003 US 2014/O256750 A1 Sep. 11, 2014 JP 2003-321357 A 11, 2003 JP 2005-516917 A 6, 2005 JP 2008O31146 A 2, 2008 Related U.S.
  • Partial Agreement in the Social and Public Health Field

    Partial Agreement in the Social and Public Health Field

    COUNCIL OF EUROPE COMMITTEE OF MINISTERS (PARTIAL AGREEMENT IN THE SOCIAL AND PUBLIC HEALTH FIELD) RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies, and superseding Resolution AP (82) 2) AND APPENDIX I Alphabetical list of medicines adopted by the Public Health Committee (Partial Agreement) updated to 1 July 1988 APPENDIX II Pharmaco-therapeutic classification of medicines appearing in the alphabetical list in Appendix I updated to 1 July 1988 RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (superseding Resolution AP (82) 2) (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies) The Representatives on the Committee of Ministers of Belgium, France, the Federal Republic of Germany, Italy, Luxembourg, the Netherlands and the United Kingdom of Great Britain and Northern Ireland, these states being parties to the Partial Agreement in the social and public health field, and the Representatives of Austria, Denmark, Ireland, Spain and Switzerland, states which have participated in the public health activities carried out within the above-mentioned Partial Agreement since 1 October 1974, 2 April 1968, 23 September 1969, 21 April 1988 and 5 May 1964, respectively, Considering that the aim of the Council of Europe is to achieve greater unity between its members and that this
  • 123. Antimony

    123. Antimony

    1998:11 The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 123. Antimony John Erik Berg Knut Skyberg Nordic Council of Ministers arbete och hälsa vetenskaplig skriftserie ISBN 91–7045–471–x ISSN 0346–7821 http://www.niwl.se/ah/ah.htm National Institute for Working Life National Institute for Working Life The National Institute for Working Life is Sweden's center for research and development on labour market, working life and work environment. Diffusion of infor- mation, training and teaching, local development and international collaboration are other important issues for the Institute. The R&D competence will be found in the following areas: Labour market and labour legislation, work organization and production technology, psychosocial working conditions, occupational medicine, allergy, effects on the nervous system, ergonomics, work environment technology and musculoskeletal disorders, chemical hazards and toxicology. A total of about 470 people work at the Institute, around 370 with research and development. The Institute’s staff includes 32 professors and in total 122 persons with a postdoctoral degree. The National Institute for Working Life has a large international collaboration in R&D, including a number of projects within the EC Framework Programme for Research and Technology Development. ARBETE OCH HÄLSA Redaktör: Anders Kjellberg Redaktionskommitté: Anders Colmsjö och Ewa Wigaeus Hjelm © Arbetslivsinstitutet & författarna 1998 Arbetslivsinstitutet, 171 84 Solna, Sverige ISBN 91–7045–471–X ISSN 0346-7821 Tryckt hos CM Gruppen Preface The Nordic Council is an intergovernmental collaborative body for the five countries, Denmark, Finland, Iceland, Norway and Sweden. One of the committees, the Nordic Senior Executive Committee for Occupational Environmental Matters, initiated a project in order to produce criteria documents to be used by the regulatory authorities in the Nordic countries as a scientific basis for the setting of national occupational exposure limits.
  • Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set

    Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set

    MTC eHealth DSI [eHDSI v2.2.2-OR] eHealth DSI – Master Value Set Catalogue Responsible : eHDSI Solution Provider PublishDate : Wed Nov 08 16:16:10 CET 2017 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 1 of 490 MTC Table of Contents epSOSActiveIngredient 4 epSOSAdministrativeGender 148 epSOSAdverseEventType 149 epSOSAllergenNoDrugs 150 epSOSBloodGroup 155 epSOSBloodPressure 156 epSOSCodeNoMedication 157 epSOSCodeProb 158 epSOSConfidentiality 159 epSOSCountry 160 epSOSDisplayLabel 167 epSOSDocumentCode 170 epSOSDoseForm 171 epSOSHealthcareProfessionalRoles 184 epSOSIllnessesandDisorders 186 epSOSLanguage 448 epSOSMedicalDevices 458 epSOSNullFavor 461 epSOSPackage 462 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 2 of 490 MTC epSOSPersonalRelationship 464 epSOSPregnancyInformation 466 epSOSProcedures 467 epSOSReactionAllergy 470 epSOSResolutionOutcome 472 epSOSRoleClass 473 epSOSRouteofAdministration 474 epSOSSections 477 epSOSSeverity 478 epSOSSocialHistory 479 epSOSStatusCode 480 epSOSSubstitutionCode 481 epSOSTelecomAddress 482 epSOSTimingEvent 483 epSOSUnits 484 epSOSUnknownInformation 487 epSOSVaccine 488 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 3 of 490 MTC epSOSActiveIngredient epSOSActiveIngredient Value Set ID 1.3.6.1.4.1.12559.11.10.1.3.1.42.24 TRANSLATIONS Code System ID Code System Version Concept Code Description (FSN) 2.16.840.1.113883.6.73 2017-01 A ALIMENTARY TRACT AND METABOLISM 2.16.840.1.113883.6.73 2017-01
  • General Pharmacology

    General Pharmacology

    GENERAL PHARMACOLOGY Winners of “Nobel” prize for their contribution to pharmacology Year Name Contribution 1923 Frederick Banting Discovery of insulin John McLeod 1939 Gerhard Domagk Discovery of antibacterial effects of prontosil 1945 Sir Alexander Fleming Discovery of penicillin & its purification Ernst Boris Chain Sir Howard Walter Florey 1952 Selman Abraham Waksman Discovery of streptomycin 1982 Sir John R.Vane Discovery of prostaglandins 1999 Alfred G.Gilman Discovery of G proteins & their role in signal transduction in cells Martin Rodbell 1999 Arvid Carlson Discovery that dopamine is neurotransmitter in the brain whose depletion leads to symptoms of Parkinson’s disease Drug nomenclature: i. Chemical name ii. Non-proprietary name iii. Proprietary (Brand) name Source of drugs: Natural – plant /animal derivatives Synthetic/semisynthetic Plant Part Drug obtained Pilocarpus microphyllus Leaflets Pilocarpine Atropa belladonna Atropine Datura stramonium Physostigma venenosum dried, ripe seed Physostigmine Ephedra vulgaris Ephedrine Digitalis lanata Digoxin Strychnos toxifera Curare group of drugs Chondrodendron tomentosum Cannabis indica (Marijuana) Various parts are used ∆9Tetrahydrocannabinol (THC) Bhang - the dried leaves Ganja - the dried female inflorescence Charas- is the dried resinous extract from the flowering tops & leaves Papaver somniferum, P album Poppy seed pod/ Capsule Natural opiates such as morphine, codeine, thebaine Cinchona bark Quinine Vinca rosea periwinkle plant Vinca alkaloids Podophyllum peltatum the mayapple
  • Government Gazette

    Government Gazette

    Government Gazette REPUBLIC OF SOUTH AFRICA Regulation Gazette No. 7636 Vol. 454 Pretoria 10 April 2003 No. 24727 AIDS HELPLINE: 0800-0123-22 Prevention is the cure I STAATSKOERANT, 10 APRIL 2003 No. 24727 3 GOVERNMENT NOTICES GOEWERMENTSKENNISGEWINGS DEPARTMENT OF HEALTH DEPARTEMENT VAN GESONDHEID NO. R. 509 10 April 2003 SCHEDULES The Minister of Health has, in terms of section 22A(2) of the Medicines and Related Substances Act, 1965 (Act No. 101 of 1965), on the recommendation of the Medicines Control Council, made the Schedulesin the Schedule SCHEDULE I In these Schedules, "the Act" meansthe Medicines and Related SubstancesAct, 1965 (Act No. 101 of 1965) SCHEDULE 0 (a) All substancesreferred to in thisSchedule are excluded when specifically packed, labelled and usedfor - (i) industrialpurposes including the manufacture or compounding of consumer items or products which have no pharmacological oraction medicinal purpose, which are intended to be ingested by man or animals as food, or applied to the body as a cosmetic, and which are approved for such use in terms of the Foodstuffs, Cosmetics and Disinfectants Act, 1972 (Act No. 54 of 1972) or registeredin terms of theFertilizers, Farm Feeds, Agricultural Remedies and Stock Remedies Act, 1947 (Act No. 36 of 1947); and (ii)analytical laboratory purposes. (b) All substances referred to in this Schedule include the following: 4 No. 24727 GOVERNMENT GAZETTE, 10 APRIL 2003 (i) The saltsand esters of suchsub2ances,+vhere the existence of such salts and esters is possible; and (ii) All preparationsand mixtures of suchsubstances where such preparations and mixtures arenot expressly excluded. This Schedule includesall substances subject to registration in termsof the Act and which are not listed in anyof the other Schedules.
  • Marrakesh Agreement Establishing the World Trade Organization

    Marrakesh Agreement Establishing the World Trade Organization

    No. 31874 Multilateral Marrakesh Agreement establishing the World Trade Organ ization (with final act, annexes and protocol). Concluded at Marrakesh on 15 April 1994 Authentic texts: English, French and Spanish. Registered by the Director-General of the World Trade Organization, acting on behalf of the Parties, on 1 June 1995. Multilat ral Accord de Marrakech instituant l©Organisation mondiale du commerce (avec acte final, annexes et protocole). Conclu Marrakech le 15 avril 1994 Textes authentiques : anglais, français et espagnol. Enregistré par le Directeur général de l'Organisation mondiale du com merce, agissant au nom des Parties, le 1er juin 1995. Vol. 1867, 1-31874 4_________United Nations — Treaty Series • Nations Unies — Recueil des Traités 1995 Table of contents Table des matières Indice [Volume 1867] FINAL ACT EMBODYING THE RESULTS OF THE URUGUAY ROUND OF MULTILATERAL TRADE NEGOTIATIONS ACTE FINAL REPRENANT LES RESULTATS DES NEGOCIATIONS COMMERCIALES MULTILATERALES DU CYCLE D©URUGUAY ACTA FINAL EN QUE SE INCORPOR N LOS RESULTADOS DE LA RONDA URUGUAY DE NEGOCIACIONES COMERCIALES MULTILATERALES SIGNATURES - SIGNATURES - FIRMAS MINISTERIAL DECISIONS, DECLARATIONS AND UNDERSTANDING DECISIONS, DECLARATIONS ET MEMORANDUM D©ACCORD MINISTERIELS DECISIONES, DECLARACIONES Y ENTEND MIENTO MINISTERIALES MARRAKESH AGREEMENT ESTABLISHING THE WORLD TRADE ORGANIZATION ACCORD DE MARRAKECH INSTITUANT L©ORGANISATION MONDIALE DU COMMERCE ACUERDO DE MARRAKECH POR EL QUE SE ESTABLECE LA ORGANIZACI N MUND1AL DEL COMERCIO ANNEX 1 ANNEXE 1 ANEXO 1 ANNEX
  • WO 2016/154503 Al 29 September 2016 (29.09.2016) P O P C T

    WO 2016/154503 Al 29 September 2016 (29.09.2016) P O P C T

    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/154503 Al 29 September 2016 (29.09.2016) P O P C T (51) International Patent Classification: Saujanya; 33 12 Cornelia Court, Jamestown, NC 27282 A61K 9/48 (2006.01) A61K 47/12 (2006.01) (US). YANG, Chue; 302 Kensington Road, Greensboro, A61K 9/64 (2006.01) A61K 47/42 (2006.01) NC 27403 (US). VAN DUIJNHOVEN, Henricus A61K 9/66 (2006.01) Marinus, Gerardus, Maria; Loevestein 9, 5235 GC Den Bosch (NL). PIEST, Martin; Smijersstraat 66, 5012 CD (21) International Application Number: Tilburg (NL). FATMI, Aqeel, A.; 4125 Premier Drive, PCT/US20 16/024 127 High Point, NC 27265 (US). (22) International Filing Date: (74) Agent: BROWN, Bernard, A., II; Brinks Gilson & Lione, 25 March 2016 (25.03.2016) Post Office Box 110285, Research Triangle Park, NC (25) Filing Language: English 27709 (US). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 62/138,468 26 March 2015 (26.03.2015) US BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, 62/236,297 2 October 201 5 (02. 10.2015) US DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (71) Applicant: BANNER LIFE SCIENCES LLC [US/US]; HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 4125 Premier Drive, High Point, NC 27265 (US).
  • Chemical Names and CAS Numbers Final

    Chemical Names and CAS Numbers Final

    Chemical Abstract Chemical Formula Chemical Name Service (CAS) Number C3H8O 1‐propanol C4H7BrO2 2‐bromobutyric acid 80‐58‐0 GeH3COOH 2‐germaacetic acid C4H10 2‐methylpropane 75‐28‐5 C3H8O 2‐propanol 67‐63‐0 C6H10O3 4‐acetylbutyric acid 448671 C4H7BrO2 4‐bromobutyric acid 2623‐87‐2 CH3CHO acetaldehyde CH3CONH2 acetamide C8H9NO2 acetaminophen 103‐90‐2 − C2H3O2 acetate ion − CH3COO acetate ion C2H4O2 acetic acid 64‐19‐7 CH3COOH acetic acid (CH3)2CO acetone CH3COCl acetyl chloride C2H2 acetylene 74‐86‐2 HCCH acetylene C9H8O4 acetylsalicylic acid 50‐78‐2 H2C(CH)CN acrylonitrile C3H7NO2 Ala C3H7NO2 alanine 56‐41‐7 NaAlSi3O3 albite AlSb aluminium antimonide 25152‐52‐7 AlAs aluminium arsenide 22831‐42‐1 AlBO2 aluminium borate 61279‐70‐7 AlBO aluminium boron oxide 12041‐48‐4 AlBr3 aluminium bromide 7727‐15‐3 AlBr3•6H2O aluminium bromide hexahydrate 2149397 AlCl4Cs aluminium caesium tetrachloride 17992‐03‐9 AlCl3 aluminium chloride (anhydrous) 7446‐70‐0 AlCl3•6H2O aluminium chloride hexahydrate 7784‐13‐6 AlClO aluminium chloride oxide 13596‐11‐7 AlB2 aluminium diboride 12041‐50‐8 AlF2 aluminium difluoride 13569‐23‐8 AlF2O aluminium difluoride oxide 38344‐66‐0 AlB12 aluminium dodecaboride 12041‐54‐2 Al2F6 aluminium fluoride 17949‐86‐9 AlF3 aluminium fluoride 7784‐18‐1 Al(CHO2)3 aluminium formate 7360‐53‐4 1 of 75 Chemical Abstract Chemical Formula Chemical Name Service (CAS) Number Al(OH)3 aluminium hydroxide 21645‐51‐2 Al2I6 aluminium iodide 18898‐35‐6 AlI3 aluminium iodide 7784‐23‐8 AlBr aluminium monobromide 22359‐97‐3 AlCl aluminium monochloride
  • Alphabetical Listing of ATC Drugs & Codes

    Alphabetical Listing of ATC Drugs & Codes

    Alphabetical Listing of ATC drugs & codes. Introduction This file is an alphabetical listing of ATC codes as supplied to us in November 1999. It is supplied free as a service to those who care about good medicine use by mSupply support. To get an overview of the ATC system, use the “ATC categories.pdf” document also alvailable from www.msupply.org.nz Thanks to the WHO collaborating centre for Drug Statistics & Methodology, Norway, for supplying the raw data. I have intentionally supplied these files as PDFs so that they are not quite so easily manipulated and redistributed. I am told there is no copyright on the files, but it still seems polite to ask before using other people’s work, so please contact <[email protected]> for permission before asking us for text files. mSupply support also distributes mSupply software for inventory control, which has an inbuilt system for reporting on medicine usage using the ATC system You can download a full working version from www.msupply.org.nz Craig Drown, mSupply Support <[email protected]> April 2000 A (2-benzhydryloxyethyl)diethyl-methylammonium iodide A03AB16 0.3 g O 2-(4-chlorphenoxy)-ethanol D01AE06 4-dimethylaminophenol V03AB27 Abciximab B01AC13 25 mg P Absorbable gelatin sponge B02BC01 Acadesine C01EB13 Acamprosate V03AA03 2 g O Acarbose A10BF01 0.3 g O Acebutolol C07AB04 0.4 g O,P Acebutolol and thiazides C07BB04 Aceclidine S01EB08 Aceclidine, combinations S01EB58 Aceclofenac M01AB16 0.2 g O Acefylline piperazine R03DA09 Acemetacin M01AB11 Acenocoumarol B01AA07 5 mg O Acepromazine N05AA04
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued

    Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued

    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0