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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Th eJournal of Table of Contents Immunology

VOL. 197 | NO. 9 | November 1, 2016 | Pages 3427–3748

IN THIS ISSUE 3427 Gut Foxp31RORgt1 T Cells: Origin Story See article p. 3512 Neonatal T and B Cells Experience Dichotomous Tolerance to Retroviruses See article p. 3628 JAK Signaling Threshold Determines Cytokine Secretion in Macrophages See article p. 3695

PILLARS OF IMMUNOLOGY 3429 OKT3 and H57-597: From Discovery, to Commercialization, to the Clinic Kristin A. Hogquist Downloaded from

3431 Pillars Article: OKT3: A Monoclonal Anti-Human T Lymphocyte Antibody with Potent Mitogenic Properties. J. Immunol. 1980. 124: 2708–2713 Jean P. Van Wauwe, Jan R. De Mey, and Jan G. Goossens

3437 Pillars Article: Characterization of a Monoclonal Antibody Which Detects All Murine ab T Cell Receptors. http://www.jimmunol.org/ J. Immunol. 1989. 142: 2736–2742 Ralph T. Kubo, Willi Born, John W. Kappler, Philippa Marrack, and Michele Pigeon

ALLERGY AND OTHER HYPERSENSITIVITIES 3445 IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis Laura K. Johnston, Chia-Lin Hsu, Rebecca A. Krier-Burris, Krishan D. Chhiba, Karen B. Chien, Andrew McKenzie, Sergejs Berdnikovs, and Paul J. Bryce by guest on September 28, 2021 ANTIGEN RECOGNITION AND RESPONSES 3454 TAP-Dependent and -Independent Peptide Import into Dendritic Cell Phagosomes Myriam Lawand, Anastasia Abramova, Valerie Manceau, Sebastian Springer, and Peter van Endert

AUTOIMMUNITY 3464 IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity Brinda Subbarayal, Sunil K. Chauhan, Antonio Di Zazzo, and Reza Dana

1 On the cover: Gill preparation dissected from an adult zebrafish carrying the cd4-1:mCherry reporter transgene. CD4 cells (red fluorescence) can be seen resident in the epithelium of the branchial filaments and lamellae epithelium. Dee, C. T., R. T. Nagaraju, E. I. Athanasiadis, C. Gray, L. Fernandez del Ama, S. A. Johnston, C. J. Secombes, A. Cvejic, and A. F. L. Hurlstone. 2016. CD4-transgenic zebrafish reveal tissue-resident Th2- and regulatory T cell–like populations and diverse mononuclear phagocytes. J. Immunol. 197: 3520–3530.

The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852, Phone: 301-634-7197, Fax: 301-634-7829. Subscription terms: New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices and details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/ membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issues can be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/pdf/single_issue_purchase.pdf). Reprints of individual articles are available only from authors. Periodicals postage paid at Rockville, MD 20852, and at additional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes 60 days in advance to The Journal of Immunology, Subscription Department, 1451 Rockville Pike, Suite 650, Rockville, MD 20852. Copyright Ó 2016 by The American Association of Immunologists, Inc. 3471 CFHR1-Modified Neural Stem Cells Ameliorated Brain Injury in a Mouse Model of Neuromyelitis Optica Spectrum Disorders Kaibin Shi, Zhen Wang, Yuanchu Liu, Ye Gong, Ying Fu, Shaowu Li, Kristofer Wood, Junwei Hao, Guang-Xian Zhang, Fu-Dong Shi, and Yaping Yan CLINICAL AND HUMAN IMMUNOLOGY 3481 Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease Martin Prince Alphonse, Trang T. Duong, Chisato Shumitzu, Truong Long Hoang, Brian W. McCrindle, Alessandra Franco, Stephane Schurmans, Dana J. Philpott, Martin L. Hibberd, Jane Burns, Taco W. Kuijpers, and Rae S. M. Yeung

3490 Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease Frances T. Hakim, Sarfraz Memon, Ping Jin, Matin M. Imanguli, Huan Wang, Najibah Rehman, Xiao-Yi Yan, Jeremy Rose, Jacqueline W. Mays, Susan Dhamala, Veena Kapoor, William Telford, John Dickinson, Sean Davis, David Halverson, Haley B. Naik, Kristin Baird, Daniel Fowler, David Stroncek, Edward W. Cowen, Steven Z. Pavletic, and Ronald E. Gress

IMMUNE REGULATION Downloaded from 3504 Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration Y. Maurice Morillon, Elizabeth Chase Lessey-Morillon, Matthew Clark, Rui Zhang, Bo Wang, Keith Burridge, and Roland Tisch

3512 Antigen-Specific Development of Mucosal Foxp3+RORgt+ T Cells from Regulatory T Cell Precursors http://www.jimmunol.org/ Benjamin D. Solomon and Chyi-Song Hsieh

3520 CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell–like Populations and Diverse Mononuclear Phagocytes Christopher T. Dee, Raghavendar T. Nagaraju, Emmanouil I. Athanasiadis, Caroline Gray, Laura Fernandez del Ama, Simon A. Johnston, Christopher J. Secombes, Ana Cvejic, and Adam F. L. Hurlstone

3531 Chemotaxis and Immunoregulatory Function of Cardiac gd T Cells in Dystrophin-Deficient Mice Cynthia Machado Cascabulho, Daniela Gois Beghini, Marcelo Meuser-Batista, Carmen Penido, and by guest on September 28, 2021 Andrea Henriques-Pons

3545 Anandamide Suppresses Proinflammatory T Cell Responses In Vitro through Type-1 Cannabinoid Receptor–Mediated mTOR Inhibition in Human Keratinocytes Valerio Chiurchiu`, Cinzia Rapino, Emanuela Talamonti, Alessandro Leuti, Mirko Lanuti, Audrey Gueniche, Roland Jourdain, Lionel Breton, and Mauro Maccarrone

3554 Antigen-Specific Immune Modulation Targets mTORC1 Function To Drive Chemokine Receptor–Mediated T Cell Tolerance Weirong Chen, Xiaoxiao Wan, Tobechukwu K. Ukah, Mindy M. Miller, Subhasis Barik, Alexis N. Cattin-Roy, and Habib Zaghouani IMMUNOGENETICS 3566 A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data Ang Cui, Roberto Di Niro, Jason A. Vander Heiden, Adrian W. Briggs, Kris Adams, Tamara Gilbert, Kevin C. O’Connor, Francois Vigneault, Mark J. Shlomchik, and Steven H. Kleinstein IMMUNOTHERAPY AND VACCINES 3575 Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination Gunnveig Grodeland, Agnete Brunsvik Fredriksen, Geir A˚ge Løset, Elisabeth Vikse, Lars Fugger, and Bjarne Bogen

3586 High Doses of GM-CSF Inhibit Antibody Responses in Rectal Secretions and Diminish Modified Vaccinia Ankara/Simian Immunodeficiency Virus Vaccine Protection in TRIM5a-Restrictive Macaques Sunil Kannanganat, Linda S. Wyatt, Sailaja Gangadhara, Venkatesarlu Chamcha, Lynette S. Chea, Pamela A. Kozlowski, Celia C. LaBranche, Lakshmi Chennareddi, Benton Lawson, Pradeep B. J. Reddy, Tiffany M. Styles, Thomas H. Vanderford, David C. Montefiori, Bernard Moss, Harriet L. Robinson, and Rama Rao Amara 3597 A Tetravalent Formulation Based on Recombinant Nucleocapsid-like Particles from Dengue Viruses Induces a Functional Immune Response in Mice and Monkeys Lazaro Gil, Karem Cobas, Laura Lazo, Ernesto Marcos, Laura Hernandez, Edith Suzarte, Alienys Izquierdo, Iris Valdes, Aracelys Blanco, Pedro Puentes, Yaremis Romero, Yusleidi Perez, Mar´ia G. Guzman, Gerardo Guillen, and Lisset Hermida

3607 IL-10–Modulated Human Dendritic Cells for Clinical Use: Identification of a Stable and Migratory Subset with Improved Tolerogenic Activity Fanny Kryczanowsky, Verena Raker, Edith Graulich, Matthias P. Domogalla, and Kerstin Steinbrink

INFECTIOUS DISEASE AND HOST RESPONSE 3618 Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells Constance Laroche-Lefebvre, Mitra Yousefi, Jean-Franc¸ois Daudelin, Tania Charpentier, Esther Tarrab, Roscoe Klinck, Alain Lamarre, Nathalie Labrecque, Simona Sta¨ger, and Pascale Duplay

3628 Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy Bettina Mavrommatis, Lucie Baudino, Prisca Levy, Julia Merkenschlager, Urszula Eksmond, Tiziano Donnarumma, George Young, Jonathan Stoye, and George Kassiotis Downloaded from INNATE IMMUNITY AND INFLAMMATION 3639 HIF-2a in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis Shirley Dehn, Matthew DeBerge, Xin-Yi Yeap, Laurent Yvan-Charvet, Deyu Fang, Holger K. Eltzschig, Stephen D. Miller,

and Edward B. Thorp http://www.jimmunol.org/

3650 Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance Kae Won Cho, Brian F. Zamarron, Lindsey A. Muir, Kanakadurga Singer, Cara E. Porsche, Jennifer B. DelProposto, Lynn Geletka, Kevin A. Meyer, Robert W. O’Rourke, and Carey N. Lumeng

3662 MK2/3 Are Pivotal for IL-33–Induced and Mast Cell–Dependent Leukocyte Recruitment and the

Resulting Skin Inflammation by guest on September 28, 2021 Sebastian Drube, Florian Kraft, Jan Dudeck, Anna-Lena Mu¨ller, Franziska Weber, Christiane Go¨pfert,Isabel Meininger, Mandy Beyer, Ingo Irmler, Norman Ha¨fner, Dagmar Schu¨tz, Ralf Stumm, Tatiana Yakovleva, Matthias Gaestel, Anne Dudeck, and Thomas Kamradt

3669 Von Willebrand Factor Interacts with Surface-Bound C1q and Induces Platelet Rolling Robert Ko¨lm,Monica Schaller, Lubka T. Roumenina, Iga Niemiec, Johanna A. Kremer Hovinga, Elham Khanicheh, Beat A. Kaufmann, Helmut Hopfer, and Marten Trendelenburg

3680 Mannan-Binding Lectin–Associated Serine Protease 1/3 Cleavage of Pro–Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference–Mediated Gene Silencing Nirmal K. Banda, Sumitra Acharya, Robert I. Scheinman, Gaurav Mehta, Marilyne Coulombe, Minoru Takahashi, Hideharu Sekine, Steffen Thiel, Teizo Fujita, and V. Michael Holers

3695 JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages Matija Hedl, Deborah D. Proctor, and Clara Abraham

3705 Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation Neele Schumacher, Stefanie Schmidt, Jeanette Schwarz, Dana Dohr, Juliane Lokau, Ju¨rgen Scheller, Christoph Garbers, Athena Chalaris, Stefan Rose-John, and Bjo¨rnRabe

MUCOSAL IMMUNOLOGY 3716 Humoral Immunity Provides Resident Intestinal Eosinophils Access to Luminal Antigen via Eosinophil-Expressed Low-Affinity Fcg Receptors Kalmia M. Smith, Raiann S. Rahman, and Lisa A. Spencer TRANSPLANTATION 3725 G-CSF–Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way Suelen Martins Perobelli, Ana Carolina Terra Mercadante, Romulo^ Gonc¸alves Galvani, Triciana Gonc¸alves-Silva, Ana Paula Gregorio Alves, Antonio Pereira-Neves, Marlene Benchimol, Alberto Nobrega, and Adriana Bonomo

TUMOR IMMUNOLOGY 3735 Accumulation of CD11c+CD163+ Adipose Tissue Macrophages through Upregulation of Intracellular 11b-HSD1 in Human Obesity Shotaro Nakajima, Vivien Koh, Ley-Fang Kua, Jimmy So, Lomanto Davide, Kee Siang Lim, Sven Hans Petersen, Wei-Peng Yong, Asim Shabbir, and Koji Kono

3746 AUTHOR INDEX Downloaded from http://www.jimmunol.org/ by guest on September 28, 2021