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Lung Cancer Frontiers the Forum for Early Diagnosis and Treatment of Lung Cancer
LungSummer 2009 | NO 37 1 Cancer FRONTIERS Lung Cancer FRONTIERS The Forum for Early Diagnosis and Treatment of Lung Cancer EGFR Testing in Lung Cancer is Ready for Prime Time By Fred R. Hirsch, MD, PhD The epidermal growth factor receptor (EGFR) protein is widely expressed in non-small cell lung cancers (NSCLC). The gene is sometimes amplified, but it is often increased in copy number and, less frequently, mutated with activating mutations. EGFR-directed therapies include the reversible specific tyrosine kinase inhibitors (TKIs) gefitinib (Iressa®) and erlotinib (Tarceva®) and the monoclonal antibody cetuximab (Erbitux®). Also, more recently, irreversible pan-Her inhibitors were introduced into clinical trials. In unselected patients treated with EGFR inhibitors, a minority will achieve an objective Fred R. Hirsch, MD, PhD, response, but many more will have symptomatic improvement with stable disease. Large, is Professor of Medicine and randomized studies failed to demonstrate any additional clinical benefit by adding an Pathology, University of Colorado EGFR TKI to chemotherapy in first line treatment. However, major breakthroughs in Denver School of Medicine, University patient selection were made by studying tumor specimens from patients in these trials. of Colorado Cancer Center, Aurora, CO. He is a member of the Lung Many objective responders had EGFR mutations occurring specifically in exons 19 and 21 1 Cancer Frontiers Editorial Board. associated with never-smoker status, Asian ethnicity and adenocarcinoma histology . Single- arm studies selecting patients for these mutations showed response rates and progression free survival times superior to those seen with chemotherapy2. These studies led to recently The purpose of Lung Cancer reported randomized phase II and III trials in chemo-naive patients with advanced NSCLC. -
Philippa Marrack, Phd, FRS
Philippa Marrack, PhD, FRS Conditions Treated: Research Areas: • Basic Immunology Programs & Services: • Department of Immunology and Genomic Medicine Research Interests Most of our work over the years has focused on T cells. T cells are amongst the cells which recognize that an infection is occurring in the body. They accomplish this in an unexpected way, by reacting with fragments of the infection bound to special proteins of the body, the MHC proteins. We are trying to find out how T cells learn to react in this way. We are also interested in the ways in which T cells are prevented from attacking MHC proteins bound to fragments of their own host. In most people such attack is efficiently avoided. However, in some individuals T cells do react in this way, and this event causes autoimmune diseases such as rheumatoid arthritis and juvenile diabetes. However we do also study B cells, in particular a previously under investigated type of B cell (ABC) we first found in elderly female mice, but which has also been found by others and ourselves in women and mice with autoimmune diseases and in mice and humans with various infections including SARS-CoV-2. In mice these cells are important producers of autoantibodies and antibodies that efficiently get rid of virus infections. However, although they can produce autoantibodies in humans, their significance in infections is not currently known. Education 1967 Cambridge University, England, BA, MA 1970 Cambridge University, England, PhD Fellowship 1971 - University of California (San Diego, CA), Postdoctoral fellowship with Dr. Richard 1973 Dutton Affiliations with the University of Colorado Denver Distinguished Professor, University of Colorado Denver Professor in the Department of Immunology & Microbiology and the Depts. -
Delivering a New Promise
2008 Annual Report Delivering a New Promise The #1 Respiratory Hospital in the U.S., Since 1998 U.S. News & World Report In 1907 a group of Before antibiotics, In the 1950s, Dr. Werner Community outreach Today, in the Minimally The new Institute for Denver women founded tuberculosis patients, Shaefer improved programs at National Invasive Diagnostic Advanced Biomedical the Denver Sheltering like these at National methods for diagnosis Jewish Health help Center, physicians use Imaging™ offers Home, which cared for Jewish in 1905, often of tuberculosis and the asthma patients monitor detailed CT scans and advanced imaging children whose parents slept outside because related non-tuberculous and manage their advanced navigational capabilities for were receiving care for fresh air and sunshine mycobacterium disease. software to plan improved patient care tuberculosis at National were thought to be keys diseases. their bronchoscopic and research. Jewish and other to successful treatment. procedures. institutions. The original National Early patient on a For almost two Children come from The mycobacteriology The main National Jewish Hospital for private porch. Fresh decades, from 1948 to around the country laboratory at National Jewish Health campus Consumptives opened air and sunshinre were 1968, National Jewish to the Pediatric Day Jewish Health is one comprises 13 buildings in 1899. vital components of physicians performed Program at National of the world’s leading on 16 acres. early TB treatment. pioneering cardiac Jewish Health, a unique, laboratories in the surgery. program for treatment diagnosis and drug- of severe asthma, susceptibility testing eczema, food allergies of TB and related and related diseases. diseases. -
Mark Boguniewicz, MD
Mark Boguniewicz, MD • Professor • Division of Pediatric Allergy & Clinical Immunology • Department of Pediatrics Conditions Treated: • Medication/Drug Allergy • Hives (Urticaria) • Allergic Rhinitis (Hay Fever) • Immune Deficiency Disorders • Allergic Rhinitis (Pediatric) Programs & Services: • National Jewish Health for Kids / Pediatric • Eczema Program (Pediatric) Programs • Day Program (Pediatric) • Food Allergy Program (Pediatric) • Outpatient Clinic (Pediatric) • Division of Pediatric Allergy & Clinical • Ambulatory Pediatrics Immunology • Allergy & Asthma Program (Pediatric) • Asthma Treatment Programs (Pediatric) Research Interests My research interests include the immunology of the skin, especially as it relates to atopic dermatitis (eczema) and new treatments for this illness. Board Certification Pediatrics and Allergy-Immunology Fellowship 1985 - Boston Children’s Hospital and Harvard Medical School, Immunology, Allergy and 1988 Rheumatology Teaching or Professional Positions Professor, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine Affiliations with the University of Colorado Denver Professor, Department of Pediatrics, University of Colorado Denver Professional Memberships Fellow, AAAAI Fellow, ACAAI Member, CAAS Awards & Recognition 2015: Best Doctors in America, Best Doctors, Inc. 2013: Distinguished Clinician Award, AAAAI 2006: Richard S. Farr Memorial Lectureship 2003-2014: Best Doctors in America 2002: Clinician of the Year, National Jewish Health Faculty Award 1998-1999, 2010-2011, 2011-2012, 2012-2013: Pediatric Allergy-Immunology Fellows Outstanding Teacher Award Publications Boguniewicz M, Leung DY. Targeted therapy for allergic diseases: At the intersection of cutting- edge science and clinical practice. J Allergy Clin Immunol 2015;135:354-6. Boguniewicz M. Atopic dermatitis: The updated practice parameter and beyond. Allergy Asthma Proc 2014;35:429-34. Boguniewicz M, Leung DYM. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. -
Sequencing Vs MALDI-TOF- Tools for Accurate Identification of Non-Tuberculous
Sequencing Vs MALDI-TOF- tools for accurate identification of Non-Tuberculous Mycobacteria-a Pilot study Dissertation submitted in partial fulfilment of the rules and regulations for the M.D. (Branch-IV Microbiology) examination of the Tamilnadu Dr. M.G.R. Medical University to be held in May, 2019 1 CERTIFICATE This is to certify that the dissertation entitled, ―Sequencing Vs MALDI-TOF- tools for accurate identification of Non-Tuberculous Mycobacteria-a Pilot study‖is the bonafide work of Dr. Ann Susan Sam toward the M.D (Branch – IV Microbiology) Degree examination of the Tamil Nadu Dr.M.G.R.Medical University, to be conducted in May-2019. Dr. Joy Sarojini Michael Guide, Professor and Head of department The Principal Department of Clinical Microbiology Christian Medical College Christian Medical College Vellore-632004 Vellore- 632004 2 DECLARATION I hereby declare that this M.D Dissertation entitled ―Sequencing Vs MALDI-TOF- tools for accurate identification of Non-Tuberculous Mycobacteria-a Pilot study‖is the bonafide work done by me under the guidance of Dr. Joy Sarojini Michael, Professor, Department of Clinical Microbiology, Christian Medical College, Vellore. This work has not been submitted to any other university in part or full. Dr. Ann Susan Sam Department of Clinical Microbiology Christian Medical College Vellore 3 Plagiarism certificate 4 CERTIFICATE This is to certify that this dissertation work titled ―Sequencing Vs MALDI-TOF- tools for accurate identification of Non-Tuberculous Mycobacteria-a Pilot study‖ was done by candidate- Ann Susan Sam (Registration number- 201614351) for the award of Degree of MD Microbiology (branch IV). I have personally verified the plagiarism results on urkund.com website. -
Modern African Leaders
DOCUMENT RESUME ED 446 012 SO 032 175 AUTHOR Harris, Laurie Lanzen, Ed.; Abbey, CherieD., Ed. TITLE Biography Today: Profiles of People ofInterest to Young Readers. World Leaders Series: Modern AfricanLeaders. Volume 2. ISBN ISBN-0-7808-0015-X PUB DATE 1997-00-00 NOTE 223p. AVAILABLE FROM Omnigraphics, Inc., 615 Griswold, Detroit,MI 48226; Tel: 800-234-1340; Web site: http: / /www.omnigraphics.com /. PUB TYPE Collected Works General (020)-- Reference Materials - General (130) EDRS PRICE MF01/PC09 Plus Postage. DESCRIPTORS African History; Biographies; DevelopingNations; Foreign Countries; *Individual Characteristics;Information Sources; Intermediate Grades; *Leaders; Readability;Secondary Education IDENTIFIERS *Africans; *Biodata ABSTRACT This book provides biographical profilesof 16 leaders of modern Africa of interest to readersages 9 and above and was created to appeal to young readers in a format theycan enjoy reading and easily understand. Biographies were prepared afterextensive research, and this volume contains a name index, a general index, a place of birth index, anda birthday index. Each entry providesat least one picture of the individual profiled, and bold-faced rubrics lead thereader to information on birth, youth, early memories, education, firstjobs, marriage and family,career highlights, memorable experiences, hobbies,and honors and awards. All of the entries end with a list of highly accessiblesources designed to lead the student to further reading on the individual.African leaders featured in the book are: Mohammed Farah Aidid (Obituary)(1930?-1996); Idi Amin (1925?-); Hastings Kamuzu Banda (1898?-); HaileSelassie (1892-1975); Hassan II (1929-); Kenneth Kaunda (1924-); JomoKenyatta (1891?-1978); Winnie Mandela (1934-); Mobutu Sese Seko (1930-); RobertMugabe (1924-); Kwame Nkrumah (1909-1972); Julius Kambarage Nyerere (1922-);Anwar Sadat (1918-1981); Jonas Savimbi (1934-); Leopold Sedar Senghor(1906-); and William V. -
Where Have All the Flowers Gone? Philippa Marrack J Immunol 2018; 201:5-6; ; This Information Is Current As Doi: 10.4049/Jimmunol.1800635 of September 26, 2021
Where Have All the Flowers Gone? Philippa Marrack J Immunol 2018; 201:5-6; ; This information is current as doi: 10.4049/jimmunol.1800635 of September 26, 2021. http://www.jimmunol.org/content/201/1/5 Downloaded from Supplementary http://www.jimmunol.org/content/suppl/2018/06/18/201.1.5.DC1 Material References This article cites 15 articles, 5 of which you can access for free at: http://www.jimmunol.org/content/201/1/5.full#ref-list-1 http://www.jimmunol.org/ Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication by guest on September 26, 2021 *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2018 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Where Have All the Flowers Gone? Philippa Marrack y the 1990s, it was well established that many cells die correct (moderate) range survive (10). The question that Surh during the normal course of events in developing and Sprent addressed with the TUNEL/thymus experiments B organisms and that cell death occurs in many different was the following: “Where in the thymus does death by ne- ways. -
Ronald Joseph Harbeck, Phd
Ronald Joseph Harbeck, PhD • Professor • Director, Core and Microbiology Laboratories, ADx • Director of Immunology & Beryllium Laboratories • Department of Medicine • Division of Pathology Conditions Treated: Research Areas: • Autoimmunity/Rheumatology • Pulmonary Disease Research, Other Programs & Services: • Department of Medicine • Diagnostic Laboratories • Division of Pathology • Microbiology Laboratory Board Certification 1979: Board Certification: Diplomate, American Board of Medical Laboratory Immunology, American Academy of Microbiology. Recertification: 1998, 2001, 2004, 2007 and 2010. 1990: New York State Department of Health, Certificate as Laboratory Director 1996: New York State Department of Health, Certificate of Qualification in Cellular and Diagnostic Immunology Education 1964 University of South Dakota (Vermillion, SD), BA, Chemistry 1971 University of South Dakota (Vermillion, SD), PhD, Microbiology Fellowship 1971 - 1973 National Jewish Health, Postdoctoral Research Fellow in Immunology Affiliations with the University of Colorado Denver Professor, Department of Medicine, Division of Allergy & Clinical Immunology, University of Colorado Denver Professor, Integrated Dpartment of Immunology, University of Colorado Denver Professional Memberships American Academy of Allergy, Asthma and Immunology American Society for Microbiology American Association of Immunologists Clinical Immunology Society Association of Medical Laboratory Immunologists (Charter Member) American Association for Clinical Chemistry International Immunocompromised -
Immunotherapy (Allergy Shots)
Immunotherapy (Allergy Shots) Subcutanous immunotherapy (commonly called allergy shots) is a form of treatment to reduce your allergic reaction to allergens. Allergens are substances to which you are allergic. Remember, not all asthma is due to allergies. Research has shown allergy shots can reduce symptoms of: Allergic rhinitis (hay fever) grass, weed and tree pollen allergies Allergic asthma Dust mite allergy Animal dander allergy Insect sting allergy Allergy shots are less effective against molds and are not a useful method for the treatment of food allergy. Allergy shots consists of a series of injections (shots) with a solution containing the allergens that cause your symptoms. There are usually two phases: build-up and maintenance. Treatment build-up begins with a weak solution given once or twice a week. The strength of the solution is gradually increased with each dose. Once the strongest dosage is reached in a few months, the injections are slowly spaced apart until it reaches once a month. At this point, sensitivity to the allergens has been decreased, and a person has reached a maintenance level. Though not a cure for everyone, allergy sots can significantly reduce allergy symptoms in people who are unable to avoid allergens and who do not respond well to other medications. Allergy shots should always be given at your health care provider's office since there is a risk of a severe reaction. When Is immunotherapy recommended? If you are thinking of allergy shots, ask your health care provider about a referral to a board-certified allergist. A board-certified allergist will follow a number of steps to evaluate if allergy shots are right for you. -
Sputum Smear Examination of Adult Tuberculosis Patients Admitted in National Institute of Diseases of the Chest and Hospital (NIDCH)
Sputum smear examination of adult tuberculosis patients admitted in National Institute of Diseases of the Chest and Hospital (NIDCH) A thesis report submitted to the Department of Pharmacy, East West University, Bangladesh, in partial fulfillment of the course of Pharmaceutical Research (PHRM 404) for the degree of Bachelor of Pharmacy Submitted by Sanjida Halim Topa ID: 2008-3-70-046 Submission date: 10 July, 2012 Supervised by Dr. Sufia Islam Associate Professor, Department of Pharmacy East West University This research paper is dedicated to my beloved parents i Certificate Declaration by the Research Instructor and Department Chairperson 10 July, 2012 It is pleasure to certify that the research paper entitled “Sputum smear examination of adult tuberculosis patients admitted in National Institute of Diseases of the Chest and Hospital (NIDCH)” is prepared by Sanjida Halim Topa, a student of the Department of Pharmacy, East West University, Dhaka. She prepared the paper under my supervision. This is her original work. Dr. Sufia Islam Chairperson Department of Pharmacy East West University ii Acknowledgements All praise to the Almighty, who has made all things in my life possible. It is Him who has sustained me throughout the course of my study. I would like to extend my sincere thanks to the East West University for giving me the opportunity to conduct this study under supervision of my honorable research instructor, Dr. Sufia Islam for her scholarly guidance from the very beginning till the end of this study. I would also like to thank my research co-workers Tasnuva Tamanna and Rabita Israt whose assistance during this study aided in the process of easing my workload. -
Chief Executive Officer Search
CHIEF EXECUTIVE OFFICER SEARCH 1 Canal Street • PO Box 335 • Seneca Falls, NY 13148 • womenofthehall.org • (315) 568-8060 T HE S EA RC H The Board of Directors of the National Women’s Hall of Fame invites applications and nominations of highly experienced, energetic, and creative candidates for the position of Chief Executive Officer (CEO). Candidates should be attracted to the opportunity to provide highly transformative leadership for the nation’s premier institution honoring exceptional American women who embody the National Women’s Hall of Fame mission of “Showcasing great women . Inspiring all”. The National Women’s Hall of Fame (NWHF/the Hall) is expanding in every way – in size, in reach, in influence. To better accommodate these ambitions, the NWHF rehabilitated the historic 1844 Seneca Knitting Mill located on the Seneca-Cayuga branch of the Erie Canal in Seneca Falls, NY, and moved into it in 2020. This extraordinary achievement was completed over nine years with 10 million dollars of funding. The NWHF is eager to embrace the opportunities enabled by this new, expansive space, including honoring the importance and sense of “place” that Seneca Falls and the Erie Canal system have played in the history of the economic, social, and human rights movements of the United States of America. Following this historic move, in this historic year celebrating the centennial of women’s suffrage, the National Women’s Hall of Fame now seeks a talented, proven leader dedicated to expanding the Hall’s national footprint, advancing its fundraising capacity, strengthening its organizational structure, and planning and implementing an ambitious agenda of new programs and exhibits. -
Childrenls Diabetes Foundation at Denver
children’s diabetes foundaTION At denver — WINTER 2012 All Carousel of Hope photos: © Berliner Studio All Carousel he elegant room at the beautiful Beverly Hilton T was crowded with nearly one thousand guests for The 26th Carousel of Hope Ball in Beverly Hills, California on October 20. As always The Carousel of Hope was chaired by Barbara Davis. George Clooney, the Brass Ring Award honoree for his humanitarian work and his incomparable talent as an actor and filmmaker, was presented the award by Shirley MacLaine. (Continued on Page 10) 1. 2. 3. 4. 5. 1. George Clooney, Honoree The Carousel of Hope 2. Barbara Davis, Clive Davis 3. Shane Hendryson, Dana Davis 4. Jackie Collins, Barbara Davis, Joan Collins 5. Richard Perry, Barbara Davis, Jane Fonda ON THE COVER 1. Shirley MacLaine, George Clooney 2. David Foster 3. Neil Diamond, George Clooney 4. Neil Diamond 5. Kenny “Babyface” Edmonds, David Foster, Barbara Davis, George Clooney 2 The Carousel of Hope 1. 2. 3. 4. 5. 1. Nancy Davis, Ken Rickel, Mariella & Isabella Rickel 2. Neil Diamond, Quincy Jones, Clive Davis, Berry Gordy 3. Brad & Cassandra Grey, Carole & Bob Daly 4. Barbara Davis, George Clooney, Stacy Keibler 5. Joanna & Sidney Poitier, George Clooney 3 1. 2. 3. 4. 5. 1. Gayle King, Jay & Mavis Leno 6. 2. Corinna Fields, Ryan O’Neal 3. Neil Diamond, George Clooney 4. Jim Gianopulos 5. Jerry & Linda Bruckheimer The Carousel of Hope 6. Nicole “Nikki” Pantenburg, Kenny “Babyface” Edmonds, Terry & Jane Semel 4 The Carousel of Hope 1. 2. 3. 4. 5. 6. 1. Jolene & George Schlatter, George Clooney 2.