Ronald Joseph Harbeck, Phd

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Ronald Joseph Harbeck, PhD • Professor • Director, Core and Microbiology Laboratories, ADx • Director of Immunology & Beryllium Laboratories • Department of Medicine • Division of Pathology Conditions Treated: Research Areas: • Autoimmunity/Rheumatology • Pulmonary Disease Research, Other Programs & Services: • Department of Medicine • Diagnostic Laboratories • Division of Pathology • Microbiology Laboratory Board Certification 1979: Board Certification: Diplomate, American Board of Medical Laboratory Immunology, American Academy of Microbiology. Recertification: 1998, 2001, 2004, 2007 and 2010. 1990: New York State Department of Health, Certificate as Laboratory Director 1996: New York State Department of Health, Certificate of Qualification in Cellular and Diagnostic Immunology Education 1964 University of South Dakota (Vermillion, SD), BA, Chemistry 1971 University of South Dakota (Vermillion, SD), PhD, Microbiology Fellowship 1971 - 1973 National Jewish Health, Postdoctoral Research Fellow in Immunology Affiliations with the University of Colorado Denver Professor, Department of Medicine, Division of Allergy & Clinical Immunology, University of Colorado Denver Professor, Integrated Dpartment of Immunology, University of Colorado Denver Professional Memberships American Academy of Allergy, Asthma and Immunology American Society for Microbiology American Association of Immunologists Clinical Immunology Society Association of Medical Laboratory Immunologists (Charter Member) American Association for Clinical Chemistry International Immunocompromised Host Society American Academy of Microbiology Awards & Recognition 2004: Faculty Good Citizen Award, National Jewish Health 1997: Fellow, American Academy of Microbiology 1988: Fellow, Assoc. of Medical Laboratory Immunologists 1971-1973: NIH Postdoctoral Fellowship, National Jewish Health 1966-1971: NIH Predoctoral Fellowship, Dept of Microbiology, University of South Dakota Publications Yasnowsky KM, Dreskin SC, Efaw B, Schoen D, Vedanthan PK, Alam R, Harbeck RJ. Chronic Urticaria Sera Increase Basophil CD203c Expression• J Allergy Clin Immunol, 117(6):1430-4, 2006. Armstrong M, Liu AH, Harbeck R, Reisdorph R, Rabinovitch N, Reisdorph N. Leukotriene- E4 in human urine: Comparison of on-line purification and liquid chromatography-tandem mass spectrometry to affinity purification followed by enzyme immunoassay. Journal of Chromatography B Analyt Technol Biomed Life Sci. 877(27):3160-74, 2009. Accetta D, Syverson G, Bonacci B, Reddy S, Bengtson C, Surfus J, Harbeck R, Huttenlocher A, Grossman W, Routes J, Verbsky J. Human phagocyte defect due to Rac2 mutation detected by neonatal screening for T cell lymphopenia. J Allergy Clin Immunol. 2011;127(2):535-538. Milgrom H, Kesler K, Byron M, Harbeck R, Holliday R, Leung DY. Response to cutaneous immunization with low-molecular-weight subunit keyhole limpet hemocyanin (KLH). Int Arch Allergy and Immunol. 157(3):269-274, 2011. Van Dyke MV, Martyny JM, Marola J, Ramamoorthy P, Ridder A, Harbeck RJ, Rose, CS. Efficacy of Occupant-Collected Dust Samples in the Evaluation of Residential Allergen and Fungal Levels. J. Occup Environ Hyg, 9(1):14-24, 2012. Doctor's Contact Information Office: 877.225.5654 Fax: 303.270.2125 Locations National Jewish Health Main Campus 1400 Jackson St. Denver, CO 80206.

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Lung Cancer Frontiers the Forum for Early Diagnosis and Treatment of Lung Cancer
LungSummer 2009 | NO 37 1 Cancer FRONTIERS Lung Cancer FRONTIERS The Forum for Early Diagnosis and Treatment of Lung Cancer EGFR Testing in Lung Cancer is Ready for Prime Time By Fred R. Hirsch, MD, PhD The epidermal growth factor receptor (EGFR) protein is widely expressed in non-small cell lung cancers (NSCLC). The gene is sometimes amplified, but it is often increased in copy number and, less frequently, mutated with activating mutations. EGFR-directed therapies include the reversible specific tyrosine kinase inhibitors (TKIs) gefitinib (Iressa®) and erlotinib (Tarceva®) and the monoclonal antibody cetuximab (Erbitux®). Also, more recently, irreversible pan-Her inhibitors were introduced into clinical trials. In unselected patients treated with EGFR inhibitors, a minority will achieve an objective Fred R. Hirsch, MD, PhD, response, but many more will have symptomatic improvement with stable disease. Large, is Professor of Medicine and randomized studies failed to demonstrate any additional clinical benefit by adding an Pathology, University of Colorado EGFR TKI to chemotherapy in first line treatment. However, major breakthroughs in Denver School of Medicine, University patient selection were made by studying tumor specimens from patients in these trials. of Colorado Cancer Center, Aurora, CO. He is a member of the Lung Many objective responders had EGFR mutations occurring specifically in exons 19 and 21 1 Cancer Frontiers Editorial Board. associated with never-smoker status, Asian ethnicity and adenocarcinoma histology . Single- arm studies selecting patients for these mutations showed response rates and progression free survival times superior to those seen with chemotherapy2. These studies led to recently The purpose of Lung Cancer reported randomized phase II and III trials in chemo-naive patients with advanced NSCLC.
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