NASA Scientist John C. Mather Wins 2006 Nobel Physics Prize Pg 3
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Jul/Aug 2013
I NTERNATIONAL J OURNAL OF H IGH -E NERGY P HYSICS CERNCOURIER WELCOME V OLUME 5 3 N UMBER 6 J ULY /A UGUST 2 0 1 3 CERN Courier – digital edition Welcome to the digital edition of the July/August 2013 issue of CERN Courier. This “double issue” provides plenty to read during what is for many people the holiday season. The feature articles illustrate well the breadth of modern IceCube brings particle physics – from the Standard Model, which is still being tested in the analysis of data from Fermilab’s Tevatron, to the tantalizing hints of news from the deep extraterrestrial neutrinos from the IceCube Observatory at the South Pole. A connection of a different kind between space and particle physics emerges in the interview with the astronaut who started his postgraduate life at CERN, while connections between particle physics and everyday life come into focus in the application of particle detectors to the diagnosis of breast cancer. And if this is not enough, take a look at Summer Bookshelf, with its selection of suggestions for more relaxed reading. To sign up to the new issue alert, please visit: http://cerncourier.com/cws/sign-up. To subscribe to the magazine, the e-mail new-issue alert, please visit: http://cerncourier.com/cws/how-to-subscribe. ISOLDE OUTREACH TEVATRON From new magic LHC tourist trail to the rarest of gets off to a LEGACY EDITOR: CHRISTINE SUTTON, CERN elements great start Results continue DIGITAL EDITION CREATED BY JESSE KARJALAINEN/IOP PUBLISHING, UK p6 p43 to excite p17 CERNCOURIER www. -
A Comprehensive Framework to Reinforce Evidence Synthesis Features in Cloud-Based Systematic Review Tools
applied sciences Article A Comprehensive Framework to Reinforce Evidence Synthesis Features in Cloud-Based Systematic Review Tools Tatiana Person 1,* , Iván Ruiz-Rube 1 , José Miguel Mota 1 , Manuel Jesús Cobo 1 , Alexey Tselykh 2 and Juan Manuel Dodero 1 1 Department of Informatics Engineering, University of Cadiz, 11519 Puerto Real, Spain; [email protected] (I.R.-R.); [email protected] (J.M.M.); [email protected] (M.J.C.); [email protected] (J.M.D.) 2 Department of Information and Analytical Security Systems, Institute of Computer Technologies and Information Security, Southern Federal University, 347922 Taganrog, Russia; [email protected] * Correspondence: [email protected] Abstract: Systematic reviews are powerful methods used to determine the state-of-the-art in a given field from existing studies and literature. They are critical but time-consuming in research and decision making for various disciplines. When conducting a review, a large volume of data is usually generated from relevant studies. Computer-based tools are often used to manage such data and to support the systematic review process. This paper describes a comprehensive analysis to gather the required features of a systematic review tool, in order to support the complete evidence synthesis process. We propose a framework, elaborated by consulting experts in different knowledge areas, to evaluate significant features and thus reinforce existing tool capabilities. The framework will be used to enhance the currently available functionality of CloudSERA, a cloud-based systematic review Citation: Person, T.; Ruiz-Rube, I.; Mota, J.M.; Cobo, M.J.; Tselykh, A.; tool focused on Computer Science, to implement evidence-based systematic review processes in Dodero, J.M. -
Molecular Biology for Computer Scientists
CHAPTER 1 Molecular Biology for Computer Scientists Lawrence Hunter “Computers are to biology what mathematics is to physics.” — Harold Morowitz One of the major challenges for computer scientists who wish to work in the domain of molecular biology is becoming conversant with the daunting intri- cacies of existing biological knowledge and its extensive technical vocabu- lary. Questions about the origin, function, and structure of living systems have been pursued by nearly all cultures throughout history, and the work of the last two generations has been particularly fruitful. The knowledge of liv- ing systems resulting from this research is far too detailed and complex for any one human to comprehend. An entire scientific career can be based in the study of a single biomolecule. Nevertheless, in the following pages, I attempt to provide enough background for a computer scientist to understand much of the biology discussed in this book. This chapter provides the briefest of overviews; I can only begin to convey the depth, variety, complexity and stunning beauty of the universe of living things. Much of what follows is not about molecular biology per se. In order to 2ARTIFICIAL INTELLIGENCE & MOLECULAR BIOLOGY explain what the molecules are doing, it is often necessary to use concepts involving, for example, cells, embryological development, or evolution. Bi- ology is frustratingly holistic. Events at one level can effect and be affected by events at very different levels of scale or time. Digesting a survey of the basic background material is a prerequisite for understanding the significance of the molecular biology that is described elsewhere in the book. -
Outline of Science
Outline of science The following outline is provided as a topical overview of • Empirical method – science: • Experimental method – The steps involved in order Science – systematic effort of acquiring knowledge— to produce a reliable and logical conclusion include: through observation and experimentation coupled with logic and reasoning to find out what can be proved or 1. Asking a question about a natural phenomenon not proved—and the knowledge thus acquired. The word 2. Making observations of the phenomenon “science” comes from the Latin word “scientia” mean- 3. Forming a hypothesis – proposed explanation ing knowledge. A practitioner of science is called a for a phenomenon. For a hypothesis to be a "scientist". Modern science respects objective logical rea- scientific hypothesis, the scientific method re- soning, and follows a set of core procedures or rules in or- quires that one can test it. Scientists generally der to determine the nature and underlying natural laws of base scientific hypotheses on previous obser- the universe and everything in it. Some scientists do not vations that cannot satisfactorily be explained know of the rules themselves, but follow them through with the available scientific theories. research policies. These procedures are known as the 4. Predicting a logical consequence of the hy- scientific method. pothesis 5. Testing the hypothesis through an experiment – methodical procedure carried out with the 1 Essence of science goal of verifying, falsifying, or establishing the validity of a hypothesis. The 3 types of -
Principal Scientist, Pharmacology (DMPK) at Entrada Therapeutics Full-Time Opportunity in Boston, MA
Principal Scientist, Pharmacology (DMPK) at Entrada Therapeutics Full-Time Opportunity in Boston, MA Company Overview Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of biologics. Entrada’s technology enables the efficient intracellular delivery of proteins, peptides and nucleic acids, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the delivery of molecules into the cytosol. Entrada is comprised of experts and leaders in both biologics development and the rare disease space. In December 2018, Entrada closed a $59 million Series A from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital. Position Summary Entrada is hiring for a highly motivated, collaborative and innovative Principal Scientist, specializing in pharmacokinetics and pharmacology to join the Company’s intracellular biologics discovery and development efforts. The candidate will work with a world-class, multidisciplinary team of drug discovery scientists and lead the in vitro and in vivo ADME, PK, PD and toxicokinetic efforts. Specifically, the candidate will design, manage and execute in vitro and in vivo programs both in- house and at contract research organizations. The candidate will also be responsible for analyzing, interpreting and modeling -
How Science Works
PB 1 How science works The Scientific Method is traditionally presented in the first chapter of science text- books as a simple recipe for performing scientific investigations. Though many use- ful points are embodied in this method, it can easily be misinterpreted as linear and “cookbook”: pull a problem off the shelf, throw in an observation, mix in a few ques- tions, sprinkle on a hypothesis, put the whole mixture into a 350° experiment—and voila, 50 minutes later you’ll be pulling a conclusion out of the oven! That might work if science were like Hamburger Helper®, but science is complex and cannot be re- duced to a single, prepackaged recipe. The linear, stepwise representation of the process of science is simplified, but it does get at least one thing right. It captures the core logic of science: testing ideas with evidence. However, this version of the scientific method is so simplified and rigid that it fails to accurately portray how real science works. It more accurately describes how science is summarized after the fact—in textbooks and journal articles—than how sci- ence is actually done. The simplified, linear scientific method implies that scientific studies follow an unvarying, linear recipe. But in reality, in their work, scientists engage in many different activities in many different sequences. Scientific investigations often involve repeating the same steps many times to account for new information and ideas. The simplified, linear scientific method implies that science is done by individual scientists working through these steps in isolation. But in reality, science depends on interactions within the scientific community. -
Luis Alvarez: the Ideas Man
CERN Courier March 2012 Commemoration Luis Alvarez: the ideas man The years from the early 1950s to the late 1980s came alive again during a symposium to commemorate the birth of one of the great scientists and inventors of the 20th century. Luis Alvarez – one of the greatest experimental physicists of the 20th century – combined the interests of a scientist, an inventor, a detective and an explorer. He left his mark on areas that ranged from radar through to cosmic rays, nuclear physics, particle accel- erators, detectors and large-scale data analysis, as well as particles and astrophysics. On 19 November, some 200 people gathered at Berkeley to commemorate the 100th anniversary of his birth. Alumni of the Alvarez group – among them physicists, engineers, programmers and bubble-chamber film scanners – were joined by his collaborators, family, present-day students and admirers, as well as scientists whose professional lineage traces back to him. Hosted by the Lawrence Berkeley National Laboratory (LBNL) and the University of California at Berkeley, the symposium reviewed his long career and lasting legacy. A recurring theme of the symposium was, as one speaker put it, a “Shakespeare-type dilemma”: how could one person have accom- plished all of that in one lifetime? Beyond his own initiatives, Alvarez created a culture around him that inspired others to, as George Smoot put it, “think big,” as well as to “think broadly and then deep” and to take risks. Combined with Alvarez’s strong scientific standards and great care in execut- ing them, these principles led directly to the awarding of two Nobel Luis Alvarez celebrating the announcement of his 1968 Nobel prizes in physics to scientists at Berkeley – George Smoot in 2006 prize. -
The Cosmic Microwave Background: the History of Its Experimental Investigation and Its Significance for Cosmology
REVIEW ARTICLE The Cosmic Microwave Background: The history of its experimental investigation and its significance for cosmology Ruth Durrer Universit´ede Gen`eve, D´epartement de Physique Th´eorique,1211 Gen`eve, Switzerland E-mail: [email protected] Abstract. This review describes the discovery of the cosmic microwave background radiation in 1965 and its impact on cosmology in the 50 years that followed. This discovery has established the Big Bang model of the Universe and the analysis of its fluctuations has confirmed the idea of inflation and led to the present era of precision cosmology. I discuss the evolution of cosmological perturbations and their imprint on the CMB as temperature fluctuations and polarization. I also show how a phase of inflationary expansion generates fluctuations in the spacetime curvature and primordial gravitational waves. In addition I present findings of CMB experiments, from the earliest to the most recent ones. The accuracy of these experiments has helped us to estimate the parameters of the cosmological model with unprecedented precision so that in the future we shall be able to test not only cosmological models but General Relativity itself on cosmological scales. Submitted to: Class. Quantum Grav. arXiv:1506.01907v1 [astro-ph.CO] 5 Jun 2015 The Cosmic Microwave Background 2 1. Historical Introduction The discovery of the Cosmic Microwave Background (CMB) by Penzias and Wilson, reported in Refs. [1, 2], has been a 'game changer' in cosmology. Before this discovery, despite the observation of the expansion of the Universe, see [3], the steady state model of cosmology still had a respectable group of followers. -
Internationalizing the University Curricula Through Communication
DOCUMENT RESUME ED 428 409 CS 510 027 AUTHOR Oseguera, A. Anthony Lopez TITLE Internationalizing the University Curricula through Communication: A Comparative Analysis among Nation States as Matrix for the Promulgation of Internationalism, through the Theoretical Influence of Communication Rhetors and International Educators, Viewed within the Arena of Political-Economy. PUB DATE 1998-12-00 NOTE 55p.; Paper presented at the Annual Meeting of the Speech Communication Association of Puerto Rico (18th, San Juan, Puerto Rico, December 4-5, 1998). PUB TYPE Reports Research (143) Speeches/Meeting Papers (150) EDRS PRICE MF01/PC03 Plus Postage. DESCRIPTORS *College Curriculum; *Communication (Thought Transfer); Comparative Analysis; *Educational Change; Educational Research; Foreign Countries; Global Approach; Higher Education; *International Education IDENTIFIERS *Internationalism ABSTRACT This paper surveys the current situation of internationalism among the various nation states by a comparative analysis, as matrix, to promulgate the internationalizing process, as a worthwhile goal, within and without the college and university curricula; the theoretical influence and contributions of scholars in communication, international education, and political-economy, moreover, become allies toward this endeavor. The paper calls for the promulgation of a new and more effective educational paradigm; in this respect, helping the movement toward the creation of new and better schools for the next millennium. The paper profiles "poorer nations" and "richer nations" and then views the United States, with its enormous wealth, leading technology, vast educational infrastructure, and its respect for democratic principles, as an agent with agencies that can effect positive consequences to ameliorating the status quo. The paper presents two hypotheses: the malaise of the current educational paradigm is real, and the "abertura" (opening) toward a better paradigmatic, educational pathway is advisable and feasible. -
Application Scientist (M/F/D) Biophysical Methods
CAREERS JOIN OUR TEAM Application Scientist (m/f/d) Biophysical Methods Munich, Germany We are a growing provider of scientific instruments for the analysis of molecular interactions and are seeking highly motivated individuals to join our team as Application Scientists for our innovative heliX® biosensors. We welcome applications from high-potentials who want to use their innovative minds to realize novel biophysical assays and to push the limits of what is possible in biosensing. If you like: • applied science and collaborating with scientists, technical sales, software developers and engineers • advanced scientific instruments for high-end research challenges in academia and industry • conformational changes, molecular interactions and investigating binding kinetics, affinities, enzymatic activity, and thermodynamics of biomolecules • advancing a pioneering biosensing technology (switchSENSE®), developing new biophysical assays to fight cancer and other diseases, and being embedded at the forefront of next-generation drug development • being a technical expert who enjoys providing advice, training, and hands-on support • traveling and an international work environment And if you have: • a friendly personality with great team spirit • training in biophysics, physics, biochemistry, chemistry, molecular biology, biotechnology, or similar (MSc, or PhD level) • a positive, hands-on attitude combined with a relentless will to get things to work • excellent communication and presentation skills • the ability to manage several projects simultaneously -
Reversed out (White) Reversed
Berkeley rev.( white) Berkeley rev.( FALL 2014 reversed out (white) reversed IN THIS ISSUE Berkeley’s Space Sciences Laboratory Tabletop Physics Bringing More Women into Physics ALUMNI NEWS AND MORE! Cover: The MAVEN satellite mission uses instrumentation developed at UC Berkeley's Space Sciences Laboratory to explore the physics behind the loss of the Martian atmosphere. It’s a continuation of Berkeley astrophysicist Robert Lin’s pioneering work in solar physics. See p 7. photo credit: Lockheed Martin Physics at Berkeley 2014 Published annually by the Department of Physics Steven Boggs: Chair Anil More: Director of Administration Maria Hjelm: Director of Development, College of Letters and Science Devi Mathieu: Editor, Principal Writer Meg Coughlin: Design Additional assistance provided by Sarah Wittmer, Sylvie Mehner and Susan Houghton Department of Physics 366 LeConte Hall #7300 University of California, Berkeley Berkeley, CA 94720-7300 Copyright 2014 by The Regents of the University of California FEATURES 4 12 18 Berkeley’s Space Tabletop Physics Bringing More Women Sciences Laboratory BERKELEY THEORISTS INVENT into Physics NEW WAYS TO SEARCH FOR GOING ON SIX DECADES UC BERKELEY HOSTS THE 2014 NEW PHYSICS OF EDUCATION AND SPACE WEST COAST CONFERENCE EXPLORATION Berkeley theoretical physicists Ashvin FOR UNDERGRADUATE WOMEN Vishwanath and Surjeet Rajendran IN PHYSICS Since the Space Lab’s inception are developing new, small-scale in 1959, Berkeley physicists have Women physics students from low-energy approaches to questions played important roles in many California, Oregon, Washington, usually associated with large-scale of the nation’s space-based scientific Alaska, and Hawaii gathered on high-energy particle experiments. -
Mysteries of the Universe
Mysteries of the Universe Harry Ringermacher, Ph.D. General Electric Research Center Schenectady, NY Elliott-Nowell-White Science Symposium Oct. 11, 2012 Overview • Astronomy 101 - Scales of distance, light measure • The “Big-Bang Universe” – how we see • What do we know about Dark Matter and Dark Energy ? • The search for Dark Matter “Astronomy 101” Andromeda galaxy photo by H. Ringermacher Milky Way scaled against our nearest neighbor galaxy, Andromeda 100,000 Ly 1 light year = distance light travels in 1 year 6,000,000,000,000 miles Time-line of the Universe Wilkinson Microwave Anisotropy Probe – WMAP (2001) Cosmic Background Explorer COBE – forerunner (1989) WMAP produced unprecedented images of the earliest light in the universe – the Cosmic Microwave Background (CMB) What did WMAP discover? • Universe is 13.7 billion years old , (± 1%) • First stars ignited 200 million years after the Big Bang . • Light in the WMAP picture is from 379,000 years after the Big Bang . • Content of the Universe: 4% Atoms, 23% Cold Dark Matter, 73% Dark Energy . • The Universe will expand forever (it is “flat”) and is accelerating . • The nature of the Dark Energy and Dark Matter is still a mystery . 2006 Nobel Prize in Physics Blackbody from and anisotropy of the Cosmic Microwave Background Radiation John Mather George Smoot NASA Goddard UC Berkeley The Accelerating Universe • How do we measure the speed of expansion? • Astronomers use “Standard Candles” • Astronomers use the brightest “candle” SUPERNOVA 2011 Nobel Prize in Physics Discovery of the accelerating expansion of the universe through observations of distant supernovae Brian Schmidt, Australian Nat’l U.