INDEX

Volume 238, July-September, 1986

A23187, endothelium-dependent relaxation, agonists, calcium utilization in aorta ride flux across brain membranes, pulmonary vessels, 1055 (rats), 224 763 Abel, P. W., see Moore, D. H., 76 effect of cooling, saphenous and femo- Allen, D. 0., Ahmed, B. and Naseer, K.: Abernathy, D. R., see Todd, E. L., 642 ral veins (dogs), 139 Relationships between cyclic AMP Acara, M. A., see Ferniola, P. C., 912 pressor responses and receptor reserve, levels and lipolysis in fat cells after Acetaminophen calcium antagonists (rats), 89 isoproterenol and forskolin stirnula- conjugation, reduced hepatic energy state response coupling, saphenous and fern- tion, 659 effects (rats), 463 oral veins (dogs), 131 Ally! alcohol, hepatotoxicity due to, liver hepatotoxicity, glutathione role in pre- vasoconstriction, pulmonary circula- lobule (rats), 1132, 1138 vention, N-acetyl-L-cysteine (mice), tion (dogs), 217 Ambrose,. F., see Rinehart, R. K., 178 54 apha-2 Amiloride, prostatic secretion, drug-modi- pharmacokinetic studies, disposition, ma- effect of cooling, saphenous and femo- fled ion transport (dogs), 26 ternal-placental-fetal unit (sheep), ral veins (dogs), 139 Amino acids 198 response coupling, saphenous and fern- enzyme inactivation, retina vs. brain Acetazolamide oral veins (dogs), 131 (rats), 508 bone resorption and (mice), 778 studies that question the existence of, excitatory, striatum, phencyclidine effects renal sodium/potassium-ATPase trans- tail arteries (rats), 267 (rats), 938 port rate, transcellular NaC1 reab- vasoconstriction, pulmonary circula- -y-Aminobutynic acid sorption (dogs), 327 tion (dogs), 217 chloride flux, barbiturate alteration of, Acetazolamine, prostatic secretion, drug- alpha agonists brain membrane (mice), 763 modified ion transport (dogs), 26 antagonists, antihypertensive effects enzyme inactivation, retina vs. brain Acetylcholine (rats), 372 (rats), 508 dopamine interactions, release modula- control of microvascular reserve, myo- Aminoglycoside, nephrotoxicity, gentamicin tory receptors (rabbits), 437 cardiurn (rabbits), 868 transport, 1071 endothelium-dependent relaxation, pad- mechanical rsponses, airway smooth Aminopyrine N-demethylase, hepatic mon- monary vessels, 1055 muscle (dogs), 679 ooxygenase system, persistent de- muscarinic receptors, brain, N-methyl- radioligand selectivity, quantitative fects, phenytoin (rats), 68 scopolamine binding to (rats), 554 analysis, 46 Aniiodarone, induced biotransformation, release, presynaptic apha-1 receptor sympathetic transmission, heart (dogs), ventricular refractory periods (rats), modulation of, atria (rats), 612 334 307 N-Acetyl-L-cysteine, acetaminophen-in- thrombin-stirnulated contraction and, Amphetamine, mydniasis, mechanism duced hepatotoxicity, glutathione arteries (rabbits), 954 (rats), 788 role in prevention (mice), 54 alpha-i and apha-2, differential inhibi- Arnygdala, antidepressant drugs injected Adenosine analogs, vasodilator effects, tion by nitroglycerin, saphenous vein into, behavioral responses and (rats), spontaneous hypertension (rats), 954 (dogs), 515 758 Adenosine 3’-phosphate 5’phosphoaulfate, beta-2, cardiovascular responsiveness, Analgesia, dynorphin A, administered in- hepatic energy state, conjugation and sympathetic activation after api- trathecally, spinal cord (rats), 833 (rats), 457 nephnine (rats), 148 Anesthetics Adenosine tniphosphatase, renal sodium Adrenocorticotropin, desensitization, stirn- antihistamines and, excess tachycardia and potassium transport rate, trans- ulatory effects of nicotine (rats), 486 (dogs), 367 cellular sodium chloride reabsorption Aging, coronary arteries, transrnural electri- nitrous oxide, effect on embryos (rats), (dogs), 327 cal stimulation, catecholarnines 985 Adenylate cyclase (dogs), 319 Angiotensin, enzyme conversion inhibitor, adrenergic receptors to, atria (dogs), 886 Ahrned, B., see Allen, D. 0., 659 lungs (rabbits), 14 forskolin-stimulated, serotonin inhibi- Airway Angiotension antagonist, sympathetic vaso- tion, hippocampal membranes smooth muscle constriction and renin secretion, (guinea pigs, rats), 248 phosphatidylinositol response, cholin- presser responses, thyrotropin-re- Adkinson, N. F., Jr., see Peters, S. P, 8 ergic agonists (cattle), 273 leasing hormone (rats), 232 Adler, M. W., see Klemfuss, H., 788 relaxation, verapamil, isoproterenol Aniline, metabolism and toxicity, hemolytic Adrenergic nerves, cardiac acceleration, and prostaglandin E, (dogs), 76 anemia (rats), 1045 pharmacological analysis (rats, Akera, T., see Berlin, J. R., 632 Anions, exchange, bumetanide inhibition of, guinea pigs), 713 Albers, L. J., see Hess, E. J., 846 renal thick limbs (mice), 407 Adrenoceptors Alcohol, central nervous system depressant, Ansari, A. F., see A!kadhi, K. A., 547 apha long- and short-sleep (mice), 1028 Antagonists, see specific type CH-38083 effects (guinea pigs, rats, Aleen, A., see Cicero, T. J., 1063 Antiarrhythmic agents mice), 701 A!kadhi, K. A., Sabouni, M. H., Ansari, A. amiodarone, induced transformation, maintenance of neurogenic tone and, F. and Lokhandwala, M. F.: Activa- ventricular refractory period (rats), hindlimb vasculature (dogs), 599 tion of DA1 receptors by dopamine or 307 mechanical responses, airway smooth fenoldopam increases cyclic AMP dantrolene sodium, isolated sinoatrial and muscle (dogs), 679 levels in the renal artery but not in atrioventricular nodes, ischemia modulation of nociceptive jaw-opening the superior cervical ganglion of the model (rabbits, dogs), 206 reflex (rats, rabbits), 576 rat, 547 Anticonvulsants vascular smooth muscle, Schild plot Allan, A. M. and Harris R. A.: Anesthetic action, repetitive firing in central neurons limitations, 237 and convulsant barbiturates alter ‘y- (rats), 727 1 aminobutynic acid-stimulated chlo- behavioral toxicity, chronic ethosuximide 1145 1146 Index Vol. 238

and sodium valproate, epilepsy (ba- dilator effects, spontaneous hyper- Bay K 8644, dihydropyridine derivatives boons), 32 tension (rats), 954 and, vascular and cardiac effects modulation of behavioral effects, external Artaud, F., see Bourgoin, S., 360 (rabbits, guinea pigs), 670 discriminative stimulus (pigeons), Artery Begaud, B., see Chel!y, J. E., 665 529 coronary, age-dependent changes, cats- Behavior phenytoin, hepatic monooxygenase sys- cholamines (dogs), 319 anticonvulsant drug effects, modulation tern, persistent defects (rats), 68 smooth muscle and endothelium, musca- by external discriminative stimulus Antidepressant drugs, injected into amyg- rinic receptors, characterization (rab- (pigeons), 529 dala, behavioral responses and (rats), bits), 100 rotational, supersensitivity, apomorphine 758 tail, apha-2 adrenoceptors, question of (mice), 242 Antidiuretic hormone existence (rats), 267 schedule-controlled, benzodiazepine-like inhibition of transepithelial water flux, 2-Arylpropionic acid, enantioselective dis- drugs (monkeys), 522 urinary bladder (toad), 401 position, nonsteroidal anti-inflam- toxicity, chronic ethosuximide and so- prostaglandins and, water handling, matory drugs (rabbits), 280, 288 chum valproate, epilepsy (baboons), renal, 653 Atchison, W. D., Joshi, U. and Thornburg, 32 Antiepileptic agents, behavioral toxicity, J. E.: Irreversible suppression of cal- Belinsky, S. A., Badr, M. Z., Kauffman, F. chronic ethosuximide and sodium cium entry into nerve terminals by C. and Thurman, R. G.: Mechanism valproate (baboons), 32 methylmercury, 618 of hepatotoxicity in peniportal re- Antihistamines, local anesthetics and, ex- Atkinson, T., see Electnicwala, A., 254 gions of the liver lobule due to allyl cess tachycardia (dogs), 367 Atnia alcohol: Studies on thio!s and energy Antihypertensive agents, profile and phar- acety!choline release, presynaptic alpha-i status, 1132 macology (rats), 473 receptor modulation of (rats), 612 Belinsky, S. A., see Bath, M. Z., 1138 Anti-inflammatory drugs beta adrenergic subtypes in (dogs), 886 Belis, J. A., see Longhurst, P. A., 773 2-arylpropionic acid, enantioselective dis- quinidine and digoxin, pharmacodynamic Benet, L. Z., see Wang, L. H., 198 position (rabbits), 280, 288 interactions between (guinea pigs), Benza!konium chloride, jejunal contractil- tenoxicam, acceleration of elimination, 632 ity, after chronic ablation, myentenic cholestyramine (dogs), 295 right, transmural nerve stimulation plexus (rats), 372 Antipsychotic drugs, depolarization block (guinea pigs, rats), 713 Benzodiazepines induction, midbrain dopamine neu- Atnial natriuretic peptide, tubular site of behavioral effects (monkeys), 522 rons (rats), 1092 action, anesthesia and (dogs), 707 interactions, central thyroid-releasing Antonaccio, M. J., High, J., DeForrest, J. Atropine hormone binding sites (rats), 178 M. and Sybertz, E.: Antihypertensive antihistamines and local anesthetics, ax- peripheral-type, downregulation of [3HJ effects of 12 beta adrenoceptor antag- cess tachycardia (dogs), 367 R05-4864 binding sites, 855 onists in conscious spontaneously hy- gastrointestinal effects of hyperserotoni- receptors, see Receptors nemia and 536 pertensive rats: Relationship to (dogs), Benzoflavones, activity, placental tissues Autoradiography changes in plasma renin activity, (rats), 1108 benzodiazepine receptors, regulation, im- heart rate and sympathetic nerve Bepridil, stimulation, cardiac myofilaments aging (rats), 739 function, 378 (pigs), 502 localization of delta opioid receptors, Anxiolytic drugs, behavioral studies (pi- Bergen, J. and Kroeger, E. A.: Adreno- brain (rats), 720 geons), 1009 ceptor-mediated mechanical re- Aorta sponses of canine tracheal smooth calcium utilization, full and partial a’pha- Badr, M. Z., Belinsky, S. A., Kauffman, F. muscle, 679 1 adrenoceptor agonists (rats), 224 C. and Thurman, R. G.: Mechanism Berlin, J. R., Akera, T. and Brody, T. M.: contraction, dihydropynidines and (rab- of hepatotoxicity to periportal re- Lack of pharmacodynamic interac- bits), 670 gions of the liver lobule due to a!lyl tions between quinidine and digoxin endothe!ium-derived relaxing factor, ac- alcohol: Role ofoxygen and lipid per- in isolated atrial muscle of guinea pig tivated production, acyl-coenzyme oxidation, 1138 heart, 632 A:lysolecithin acyltransferase inhib- Bath, M. Z., see Be!insky, S. A., 1132 Bernath, S., see Vizi, E. S., 701 itors (rabbits), 352 Banner, W., Jr., see Hynes, M. R., 100 Bestatin, kelatorphan, Met-enkephalin-like thoracic, threshold synergism and poten- Barbaz, B., see Rinehart, R. K., 178 release, spinal cord (rats), 360 tiation (rabbits), 802 Barbital, central nervous system depres- Bevan, J. A., see Garland, C. J., 947 Apical membrane, sodium permeability, de- sant, long- and short-sleep (mice), Beyer, H. S., see Sharp, B. M., 486 tangent effects (toads), 415 1028 BHT-920, alpha-2 adrenoceptors, question Apomorphine Barbiturates of existence, tail arteries (rats), 267 drug interactions, autoreceptors (rabbits), anesthetic and convulsant, y-aminobu- Bicarbonate, bumetanide action, renal thick 437 tyric acid-stimulated chloride flux limbs (mice), 407 supersensitivity, rotational behavior and, brain membranes (mice), 763 Biiary excretion, acetaminophen conjuga- (mice), 242 related depressant drugs and, recurrent tion, hepatic energy state and (rats), Aprotinin, segmental nephron function inhibition of hippocampus (rats), 564 457 (rats), 155 Bardales, R. M., see Shapiro, B. H., 68 Billings, R. E., see Hansen, D. K., 985 AQ-A39, beneficial effects of, reversible Barium chloride, jejunal contractility, after Binding assay, cyclosponine (mice), 39 myocardial reperfusion damage, chronic ablation, myenteric plexus Bis-penicillamine cyclic enkephalin, locali- anesthesia and (dogs), 422 (rats), 372 zation ofdetta opioid receptors, brain AQ-AH 208, beneficial effects, reversible Barnes, J. G., see Schwertsch!ag, U., 653 (rats), 720 myocardial reperfusion damage, Barnes, P. J., see Grandordy, B. M., 273 Bittiger, H., see Rinehart, R. K., 178 anesthesia and (dogs), 422 Barrett, J. E., Witkin, J. M., Mansbach, R. Bjork, F. A., see Ryan, M. J., 473 Arachidonic acid S., Skolnick, P. and Weissman, B. A.: Bjornsson, T., see Moorman, J. R., 159 esterification and release, p-hydroxymer- Behavioral studies with anxio!ytic Blanchard, J. S., see Cubells, J. F., 508 curibenzoic acid effects, islets (rats), drugs. III. Antipunishment actions of Blood flow 809 buspirone in the pigeon do not in- myocardial ischemia, novel calcium an- lung mediator release, reduced oxygen volve benzodiazepine receptor mech- tagonist (dogs), 113 tension, 8 anisms, 1009 regional, hydralazine effects, conscious stimulus-secretion coupling and, insulin Basilar artery, vasoconstnictor neurotrans- state (dogs), 665 release (rats), 819 mitter in, serotonin as (rabbits), 880 renal, a-hANP and (dogs), 707 Anisteromycin, hypotension and renal vaso- Bass, P., see Fox, D. A., 372 Blood pressure 1986 Index 1147

beta adrenoceptor antagonists, antihyper- Caffeine, chronic administration, locomotor interactions between verapamil and mor- tensive effects (rats), 372 activity and (rats), 542 phine, physiological parameters experimental diabetes, insulin effects on Calcium (rats), 192 urinary eicosanoid excretion (rats), A23187, eicosanoid synthesis, hydrone- responsiveness, beta adrenoceptors, epi- 606 phrotic cortical interstitial cells (rab- nephrine (rats), 148 sympathectomy and (rats), 1014 bits), 95 sympathetic vasoconstriction and renin sympathetic vasoconstriction and renin antagonists secretion, pressor responses, thyro- secretion, thyrotropin-releasing hor- cahnodu!in binding drugs, renal cell an- tropin-releasing hormone (rats), 232 mone (rats), 232 oxia (rabbits), 119 Carpenter, C. L., see Greenberg, D. A., 1021 Bocchetta, A., see Corsini, G. U., 648 KB-944, myocardial ischemia (dogs), Carpenter, R., see Cohen, M. L., 860 Bombesin, gastrointestinal transit, colonic 113 Carroll, M. E., Lac, S. T., Walker, M. J., bead expulsion, supraspinal mecha- receptor reserve, alpha-i adrenoceptor- Kragh, R and Newman, T.: Effects nisms (mice), 62 mediated presser responses (rats), 89 of naltrexone on intravenous cocaine Bouboutou, R., see Bourgoin, S., 360 verapamil and morphine interactions, self-administration in rats during Bourgoin, S., Le Bars, D., Artaud, F., Clot, physiological parameters (rats), 192 food satiation and deprivation, 1 A.-M., Bouboutou, R., Fournie-Zalu- cytoplasmic free concentration, maito- Catecholamines, isolated coronary arteries, ski, M.-C., Roques, B. P., Hamon, M. toxin effects, heart muscle (guinea age-dependent changes (dogs), 319 and Cesselin, F.: Effects of kelator- pigs, rats), 1077 Central nervous system depressants, long- phan and other peptidase inhibitors cytosolic, hepatocytes exposed to carbon and short-sleep with (mice), 1028 on the in vitro and in vivo release of tetrachloride (rats), 186 Cesselin, F., see Bourgoin, S., 360 methionine-enkephalin-like material entry, synaptosomes, suppression by CGS 13080, thrombosis and, coronary ar- from the rat spinal cord, 360 methylmercury (rats), 618 tery (dogs), 497 Bousquet, P., see Solaro, R. J., 502 stimulation, bepridil, heart (pig), 502 CGS 8216, antagonism, benzodiazepine-like Brady, J. V., see Lukas, S. E., 924 ultilization, aorta, full and partial alpha- drugs (monkeys), 522 Bradycardic agents, beneficial effects, re- 1 adrenoceptor agonists (rats), 224 Chapman, K. L., see Marwood, J. F., 267 versible myocardial reperfusion dam- Calcium channel Chelly, J. E., Doursout, M.-F., Begaud, B., antagonist age, anesthesia and (dogs), 422 Tsao, C. C. and Hartley, C. J.: Effects Bradykinin, eicosanoid synthesis, hydrone- depolarization-dependent binding, of hydralazine on regional blood flow 1021 phrotic cortical interstitial cells (rab- PC12 cells, in conscious dogs, 665 serotonin receptor activation and, bits), 95 Chiu, A. T., McCall, D. E., Thoolen, M. J. uterus and jugular vein (rats), 860 Brain M. C. and Timmermans, P. B. M. blockers and calmodulin binding drugs, in 7-aminobutynic acid enzyme inactivation M.: Ca4 utilization in the constric- vitro renal cell anoxia (rabbits), 119 (rats), 508 tion of rat aorta to full and partial dantrolene sodium, isolated sinoatrial and bombesin, gastrointestinal transit and co- alpha-i adrenoceptor agonists, 224 atrioventricular nodes, ischemia lonic bead expulsion, supraspinal Chloral hydrate, central nervous system de- model (rabbits, dogs), 206 mechanisms (mice), 62 pressant, long- and short-sleep heavy metal inhibition, nerve terminals chloride channels, barbiturate effects (mice), 1028 (rats), 618 (mice), 763 Chloride, absorption, thiazide diuretic ef- inhibition, oNCS-DHP (guinea pig), 1084 formation of 1-methyl-4-phenyl-1,2,3,6- fects, distal colon (rabbits), 912 prostaglandin E, synthesis, verapamil ef- tetrahydropynidine, monoamine oxi- Chloride-bicarbonate exchange, thiazide di- fact, hydronephrotic cortical intersti- dase and (rats), 648 uretic effects, distal colon (rabbits), tial cells (rabbits), 125 localization of delta opioid receptors, au- 912 Calmodulin, binding drugs and calcium toradiography (rats), 720 Chioroquine, leukocytes, mechanisms of cell channel blockers, in vitro renal cell muscaninic acetylcholine receptors, N- association, 302 anoxia (rabbits), 119 methylscopolamine binding to (rats), Cholesterol, synthesis, ketoconazole effects, Captopril 554 905 angiotensin-converting enzyme inhibitor, sigma and phencyclidine receptor binding uptake of N-[1(S)-carboxy-(4-OH-3- Cholestyramine, tenoxicain, acceleration of sites, autoradiography (rats), 739 ‘I-phenyl)ethylJ-L-ala-L-pro, lungs elimination (dogs), 295 Breaux, S. P., see Maderazo, E. G., 453 (rabbits), 14 Cholinergic agonists, phosphatidylinositol Breeding, genetically prone or resistant to response, airway smooth muscle (cat- sympathetic vasoconstriction and renin seizures, ethanol withdrawal (mice), tle), 273 secretion, pressor responses, thyro- 170 tropin-releasing hormone (rats), 232 Cholinergic nerves Breese, G. R., see Duncan, G. E., 758 Carbachol, forskolin interaction, cyclic cardiac acceleration, pharmacological Brenner, D., see Nielson, C. P., 19 GMP lowering agent LY83583, car- analysis (rats, guinea pigs), 713 Brody, T. M., see Berlin, J. R., 632 diac preparations (rabbits), 313 peripheral, intestinal motility and (rats), Brown, J. H. and Goldstein, D.: Analysis of Carbamazepine, repetitive firing and, cen- 594 cardiac muscarinic receptors selec- tral neurons (mice), 727 Chuang, D.-M., see Roth, B. L., 480 tively recognized by nonquaternary Carbocyclic adenosine, hypotensive and Chung, A. Y. K., see Turrin, M., 14 but not by quaternary ligands, 580 renal vasodi!ator effects, sponta- Cicero, T. J., Aleem, A., Meyer, E. R., Brown, J. H., see McDonough, P. M., 612 neous hypertension (rats), 954 Schmoeker, P.F. and Miller, B. T.: Bruckert, J. W., see Mills, E., 1014 Carbonic anhydrase, bone resorption and Opiate withdrawal-induced hyposen- Buchan, P., see Wei, E. T., 783 (mice), 778 sitivity to naloxone’s effects on Bumetanide, inhibition of electrical flux, Carbon tetrachloride, exposed hepatocytes, serum luteinizing hormone in the renal thick limbs (mice), 407 cytosolic calcium (rats), 186 male rat, 1063 Bu#{241}ag, R. D., see Mattila, J., 232 Ciliax, B. J., Penney, J. B., Jr. and Young, Bunney, B. S., see Grace, A. A., 1092 yl-L-ala-L-pro, uptake, angiotensin- A. B.: In vivo [3H]flunitrazepam Burks, T. F., see Galligan, J. J., 594 converting enzyme inhibitor, lungs binding-. Imaging of receptor regula- Burks, T. F., see Koslo, R. J., 62 (rabbits), 14 tion, 749 Buspirone Carcinogenesis, chemical, nitrofurothiazole, Cimetidine, pharmacological comparison, antipunishment actions (pigeons), 1009 bladder (rats), 457 H2 blockers (dogs), 587 serotonin inhibition, forskolin-stimulated Cardiac myocytes, maitotoxin effects Cioffi, C. L. and El-Fakahany, E. E.: Short- adenylate cyclase, hippocampal (guinea pigs, rats), 1077 term desensitization of muscarinic membranes (guinea pigs, rats), 248 Cardinal, R., see Lambert, C., 307 cholinergic receptors in mouse neu- Busse, R., see F#{246}rstermann, U., 352 Cardiovascular system roblastoma cells: Selective loss of ag- 1148 Index Vol. 238

onist low-affinity and pirenzepine Cubells, J. F., Blanchard, J. S., Smith, D. Developmental pharmacology, phenytoin, high-affinity binding sites, 916 M. and Makman, M. H.: In vivo ac- Purkinje fibers (dogs), 794 Cirazoline, alpha-i and apha-2 adrenocep- tion of enzyme-activated irreversible De Vivo, M. and Maayani, S.: Characteri- tors, response coupling, saphenous inhibitors of glutamic acid decarbox- zation of the 5-hydroxytryptamine1A and femoral veins (dogs), 131 ylase and ‘y-aminobutynic acid trans- receptor-mediated inhibition of for- Cl-926, antihypertensive activity (rats), 473 aminase in retina vs. brain, 508 skolin-stimulated adenylate cyclase CL 218,872, behavioral effects (monkeys), Curtis, A. L. and Marwah, J.: Evidence for activity in guinea pig and rat hippo- 522 alpha adrenoceptor modulation of the campal membranes, 248 Clark, M. B., see Turnin, M., 14 nociceptive jaw-opening reflex in rats Diabetes mellitus Claustre, Y., Rivy, J. P., Dennis, T. and and rabbits, 576 streptozotocin-induced, urinary bladder Scatton, B.: Pharmacological studies Cuss, F. M., see Grandordy, B. M., 273 dysfunction (rats), 773 on stress-induced increase in frontal Cyclazocine, psychopharmacology of keto- urinary eicosanoid excretion, insulin ef- cortical dopamine metabolism in the cyclazocine compared with, 960 fects (rats), 606 rat, 693 Cyclic AMP Diamond, J., see MacLeod, K. M., 313 Clonidine activation of DA1 receptors, dopamine or Diarrhea, hyperserotoninemia, ketansenin, apha-2 adrenoceptors, question of exist- fenoldopam (rats), 547 atropine, and methysergide in (dogs), ence, tail arteries (rats), 267 carbachol and forskolin interaction, car- 536 jaw-opening reflex and, nociceptive (rats, diac preparations (rabbits), 313 Diazepam, behavioral effects (monkeys), rabbits), 576 dibutyryl, bone resorption induced by 522 Clot, A.-M., see Bourgoin, S., 360 (mice), 778 Diazoxide, chloride absorption and, distal Cocaine lipolysis relations, fat cells, isoproterenol colon (rabbits), 912 drug interactions, autoreceptors (rabbits), and forskolin effects (rats), 659 Diflunisa!, pharmacokinetics of, rena! fail- 437 Cyclic GMP, carbachol and forskolin inter- ure (rats), 978 self-administration, naltrexone effects actions, cardiac preparations (rab- Digoxin, interactions with quinidine, heart (rats), 1 bits), 313 atrial muscle (guinea pigs), 632 Cohen, D. M., see Ryan, M. J., 473 Cyclohexyladenosine, vasodilator effects, Dihydroalprenolol, beta adrenergic recep- Cohen, M. L., Carpenter, R., Schenck, K., hypotensive and renal (rats), 954 tore, radioligand selectivity, quanti- Wittenauer, L. and Mason, N.: Effect Cyclosporine, novel binding assay (mice), 39 tative analysis, 46 of nitrendipine, diltiazem, trifluoper- Cystopathy, diabetic (rats), 773 Dihydropynidines, vascular and cardiac ef- azine and pimozide on serotonin2 (5- Cytochrome P-450, inactivation and induc- fects, comparison with Bay K 8644 HT2) receptor activation in the rat tion, psoralen derivatives (rats), 685 (rabbits, guinea pigs), 670 uterus and jugular vein, 860 1,25-Dihydroxyvitamin D3, bone resorption Cohen, M. L., Shuman, R T., Osborne, J. and (mice), 778 Daemmgen, J. W., see Gross, G. J., 422 J. and Gesellchen, P. D.: Opioid ag- Dulls, R. L. and Klaassen, C. D.: Effect of Danon, A., Zenser, T. V., Thomasson, D. L. onist activity of IC! 174864 and its and Davis, B. B.: Effect of verapamil reduced hepatic energy state on ac- carboxypeptidase degradation prod- etaminophen conjugation in rats, 463 on prostaglandin E synthesis by by- uct, LY281217, 769 Diltiazem, serotonin contraction and, uterus dronephrotic rabbit cortical intersti- and vein (rats), 860 Collins, A. C., see Manley, R. J., 1028 tial cells in primary culture, 125 jugular Diphenyl-phenylenediamine, lipid peroxi- Colon, distal, chloride absorption, thiazide Danon, A., Zenser, T. V., Thomasson, D. L., diuretic effects (rabbits), 912 Palmier, M. 0. and Davis, B. B.: El- dation and toxicity, gentamicin-in- Conjugation, pharmacokinetic studies, ac- cosanoid synthesis by rabbit hydro- duced (rats), 83 etaminophen disposition, maternal- nephrotic cortical interstitial cells in Diuretics, inhibition of electrical flux, renal placental-fetal unit (sheep), 198 culture, 95 thick limbs (mice), 407 Contreras, P. C., Johnson, S., Freedman, R., Dantrolene sodium, electrophysiological ac- DNA, synthesis, nitrous oxide effects, em- Hoffer, B., Olsen, K., Rafferty, M. F., tions, isolated sinoatrial and atrio- bryos (rats), 985 Lessor, R. A., Rice, K. C., Jacobson, ventricular nodes, ischemia model Donlon, M. A., see Newball, H. H., 839 A. E. and O’Donohue, T. L.: Mets- (rabbits, dogs), 206 Donovan, D. W., see Smith, E. R., 26 phit, an acylating ligand for phency- Davidenko, J., Delmar, M., Oates, R. and Dopamine clidine receptors: Characterization of Jalife, J.: Electrophysiological ac- activation of DA, receptors, cyclic AMP in vivo actions in the rat, 1101 tions ofdantrolene sodium in isOlated levels and (rats), 547 Corcoran, G. B. and Wong, B. K.: Role of sinoatrial and atrioventricular nodes interactions, release modulatory receptors glutathione in prevention of acetami- and in a model of ischemia, 206 (rabbits), 437 nophen-induced hepatotoxicity by N- Davis, B. B., see Danon, A., 95, 125, 457 metabolism, stress effects, prefrontal cor- acetyl-L-cysteine in vivo: Studies Defoin, R., see Guentert, T. W., 295 tex (rats), 693 with N-acetyl-D-cysteine in mice, 54 DeForrest, J. M., see Antonaccio, M. J., 378 midbrain neurons, depolarization block Corsini, G. U., Pintus, S., Bocchetta, A., Delmar, M., see Davidenko, J., 206 in, haloperidol and (rats), i092 Piccardi, M. P. and Del Zompo, M.: Del Zompo, M., see Corsini, G. U., 648 neuromedin N activity and, ventral teg- A reactive metabolite of 1-methyl-4- Dennis, T., see Claustre, Y., 693 mental area, 1126 phenyl-1,2,3,6-tetrahydropyridine is Depolarization-dependent binding, calcium supersensitivity, rotational behavior, apo- formed in rat brain in vitro by type channel antagonist, PC12 cells, 1021 morphine (mice), 242 B monoamine oxidase, 648 Depressantdrugs, nonbarbiturate, recurrent Dosing frequency, dependence and toler- Corticosterone, kappa opioid receptor ef- inhibition of hippocampus (rats), 564 ance to pentobarbital and (cats), 1004 fects, hypothalamic-pituitary-adren- Descatoire, V., see Letteron, P., 685 Doursout, M.-F., see Chelly, J. E., 665 ocortical axis (rats), 429 Desensitization Downregu!ation, binding site, [3H]R05- Corticotropin-releasing factor, neurogenic aortic smooth muscle contraction, pheo- 4864, benzodiazepines and, 855 plasma extravasation and, paw (rats), chromocytoma (rats), 396 Doxorubicin, polymorphonuclear leuko- 783 nicotine stimulatory effects, plasma adre- cytes, alterations in oxygen metabo- Costa, E., see Roth, B. L., 480 nocorticotropin and prolactin (rats), lite generation, 19 Costa,M.,seeGalligan,J.J., 1114 486 Doxorubicinol, induced alterations, oxygen Coughenour, L. L., see Ryan, M. J., 473 Desethyl-N-acetylprocainamide, cardiovas- metabolite generation, polymorpho- Covey, J. B., see Duncan, G. E., 758 cular actions of (dogs), 893 nuclear leukocytes, 19 Crabbe, J. C., see Kosobud, A., 170 Detergents, sodium transport and, urinary Drazen, J. M., see Rossing, T. H., 874 Creese, I., see Hess, E. J., 846 bladder (toads), 415 Drug pI(, pH potentiation, sodium channel Cniswell, H., see Duncan, G. E., 758 Development, adrenergic, sympathectomy blockade, ventricular myocardium Cubeddu, L. X, see Hoffmann, I. S., 437 and (rats), 1014 (guinea pigs), 159 1986 Index 1149

Duckles, S. P., see Hynes, M. R., 100 N-[i(S)-carboxy-(4-OH-3-’9-phen- Forced swim test, antidepressant drug injec- Duckles, S. P., see Levitt, B., 880 yl)ethyl]-L-ala-L-pro, lungs (rabbits), tion and, amygdala (rats), 758 Duffey, M. E., see Ferriola, P. C., 912 14 Formyl-methionyl-leucyl-phenylalanine, Duffy, T., see Kalivas, P. W., 1126 Epilepsy, behavioral toxicity, chronic etho- hypoxia induced by, ibuprofen and Duggan, D. E., see Lin, J. H., 978 suximide and sodium valproate (ba- methylprednisolone effects on (rab- Duncan, G. E., Breese, G. R., Criswell, H., boons), 32 bits), 453 Stumpf, W. E., Mueller, R. A. and Epinephrine Forskolin Covey, J. B.: Effects of antidepres- cardiovascular responsiveness, syinpa- carbachol interaction, cyclic GMP lower- sent drugs injected into the amygdala thetic activation (rats), 148 ing agent LY83583, cardiac prepara- on behavioral responses of rats in the isoproterenol and IPS-339, sympathetic tions (rabbits), 313 forced swim test, 758 transmission, heart (dogs), 334 stimulation of fat cells, cyclic AMP and Dunham, E. W. and Vince, R.: Hypotensive Epithelial cells, plasminogen activator, lipolysis relations in (rats), 659 and renal vasodilator effects of car- thrombolytic agent, venous throm- F#{246}rstermann, U., Goppelt-Strube, M., Fr#{246}l- bocyclic adenosine (anisteromycin) in bosis (rabbits), 254 ich, J. C. and Busse, R.: Inhibitors of anesthetized spontaneously hyper- Eskinder, H. and Gross, G. J.: Differential acyl-coenzyme A:!ysolecithin-acyl- tensive rats, 954 inhibition of Alpha-i us. alpha-2 ad- transferase activate the production of Dunwiddie, T. V., Worth, T. S. and Olsen, renoceptor-mediated responses in ca- endothelium-derived vascular relax- R. W.: Facilitation of recurrent inhi- nine saphenous vein by nitroglycerin, ing factor, 352 bition in rat hippocampus by barbi- 515 Fournie-Zaluski, M.-C., see Bourgoin, S., turate and related nonbarbiturate de- Ethanol 360 pressant drugs, 564 central nervous system depressant, long- Fox, D. A. and Bass, P.: Pharmacological Duodenum, neurokinins, motor effect (rats), and short-sleep (mice), 1028 characterization of rat jejunal con- 341 withdrawal, selective breeding, geneti- tractility after chronic ablation of the Dynorphin, plasma concentrations and, an- cally prone or resistant to seizures myenteric plexus, 372 tenor pituitary hormones (primate), (mice), 170 Franz, D. R., see Newball, H. H., 839 974 Ethionine, hepatic energy state, conjugation Freedman, R., see Contreras, P. C., 1101 Dynorphin A, administered intrathecally and (rats), 457 Friedman, P. A.: Bumetanide inhibition of (rats), 8.33 Etbosuximide, sodium valproate and, be- [CO2 + HCO3]-dependent and -inde- havioral toxicity, epilepsy (baboons), pendent equivalent electrical flux in 32 renal cortical thick ascending limbs, Ehrhard, P., see Kozlowski, R., 1084 Ethoxynesorufin-O-deethylase, differential 407 Eicosanoids induction, placental tissues (rats), Frolich, J. C., see F#{246}rstermann, U., 352 synthesis, hydronephrotic cortical inter- 1108 Fructose, hepatic energy state, conjugation stitial cells (rabbits), 95 Evans, D. B., see Ryan, M. J., 473 and (rats), 457 urinary excretion, insulin effects, experi- Fujita, T., see Shebuski, R. J., 217 mental diabetes mellitus and (rats), j9-Funaltrexamine 606 Fallon, M., see Weiss, J., 969 ileal preparation (guinea pigs), 625 Eikenburg, D. C., see Schwartz, D. D., 148 Fang, F. G., Fields, H. L. and Lee, N. M.: morphine antagonism, locomotor activity Electricwala, A., Emeis, J. J. and Atkinson, Action at the mu receptor is suffi- and (rats), 997 T.: Evaluation of epithelial tissue dent to explain the supraspinal an- Furness, J.B., see Galligan, J. J., 1114 plasminogen activator as a thrombo- algesic effect of opiates, 1039 Furosemide, prostatic secretion, drug-mod- lytic agent in a rabbit model of ye- Fat cells, cyclic AMP levels and lipolysis in, ified ion transport (dogs), 26 nous thrombosis, 254 isoproterenol and forskolin stimula- Electrolytes, plasma, sodium-dependent by- tion (rats), 659 pertension and vasopressin (rats), Fenoldopam, activation of DA, receptors, Gaal, J., see Vizi, E. S., 701 492 cyclic AMP levels and (rats), 547 Galligan, J. J., Furness, J. B. and Costa, M.: Electrophysiology, bumetanide action, renal Ferrara, A., see Jaffe, B. M., 536 Effects of cholinergic blockade, ad- thick limbs (mice), 407 Fernio!a, P. C., Acara, M. A. and Duffey, M. renergic blockade and sympathetic El-Fakahany, E. E., see Cioffi, C. L., 916 E.: Thiazide diuretics inhibit chloride denervation on gastrointestinal my- El-Fakahany, E. E., Ramkumar, V. and Lai, absorption by rabbit distal colon, 912 oelectric activity in guinea pig, 1114 W. S.: Multiple binding affinities of Fibrinolysis, epithelial tissue plasminogen Galligan, J. J. and Burks, T. F.: Cholinergic N-methylscopolamine to brain mus- activator, thrombolytic agent, venous neurons mediate intestinal propul- caninic acetyicholine receptors: Dif- thrombosis (rabbits), 254 sion in the rat, 594 ferentiation from M, and M2 receptor Field, E. and Tyrey, L.: Tolerance to the Garland, C. J. and Bevan, J. A.: Alpha ad- subtypes, 554 luteinizing hormone and prolactin renoceptor antagonists selectively re- Emeis, J. J., see Electricwala, A., 254 suppressive effects of 6-9-tetrahydro- duce thrombin-stimulated contrac- Enantiomers, 2-arylpropionic acid, disposi- cannabinol develops during chronic tion in rabbit arteries, 947 tion, 2-phenylpropionic acid (rab- prepubertal treatment of female rats, Gastric antisecretory action, H2 blocker, bits), 280, 288 1034 pharmacological comparison (dogs), Endoplasmic reticulum, cytosolic calcium, Fields, H. L., see Fang, F. G., 1039 587 hepatocytes exposed to carbon tetra- Finn, I. B. and Holtzman, S. G.: Tolerance Gastrointestinal tract, colonic bead expul- chloride (rats), 186 to caffeine-induced stimulation of lo- sion and, bombesin, supraspinal Endothelium, ear artery smooth muscle and, comotor activity in rats, 542 mechanisms (mice), 62 muscarinic receptors, characteriza- Fischli, W., see Kozlowski, R., 1084 Gehlert, D. R., see Gu!ya, K., 720 tion (rabbits), 100 Flavahan, N. A. and Vanhoutte, P. M.: Al- Geneve, J., see Letteron, P., 685 Endothelium-derived relaxing factor, acti- pha-1 and alpha-2 adrenoceptor Re- Gentamicin vated production, acyl-coenzyme sponse coupling in canine saphenous lipid peroxidation and toxicity, diphenyl- A:lysolecithin acyltransferase inbib- and femoral veins, 131 phenylenediamine effects, renal cor- itors (rabbits), 352 Flavahan, N. A. and Vanhoutte, P. M.: Ef- tex (rats), 83 Endaley, B., see Picker, M., 529 fect of cooling on alpha-i and alpha- transport, renal epithelial cell line, 1071 Enkaphalin, opioid agonist activity of IC! 2 adrenergic responses in canine sa- Gerber, J. G., see Schwertschlag, U., 653 174864 (mice), 769 pbenous and femoral veins, 139 Gesellchen, P. D., see Cohen, M. L., 769 Enteric nervous system, myoelectric activ- Flunitrazepam, binding, imaging of receptor Gibb, J. W., see Sonsalla, P. K., 932 ity, nervous control (guinea pigs), regulation (rats), 749 Gilbeau, P. M., Hosobuchi, Y. and Lee, N. 1114 Folic acid, nitrous oxide effects, embryos M.: Dynorphin effects on plasma Enzymes, angiotensin-converting, uptake of (rats), 985 concentrations of anterior pituitary 1150 Index Vol. 238

hormones in the nonhuman primate, Haertzen, C. A., see Kumor, K. M., 960 treatment on the biochemical and be- 974 Hall, G. E. and Kenny, A. D.: Bone resorp- havioral properties of D1 and D2 do- Gillis, C. N., see Turrin, M., 14 tion induced by parathyroid hormone pamine receptors: Potentiated be- Ginsburg, R., see Rosenbaum, J. S., 396 and dibutyryl cyclic AMP: Role of havioral responses to a D2 dopamine Giuliani, S., see Maggi, C. A., 259, 341 carbonic anhydrase, 778 agonist after selective D1 dopamine Glial cells, LRM55, substance P receptors Halopenidol, depolarization block induction, receptor upregulation, 846 On, 389 midbrain dopamine neurons (rats), Hexobarbital hydroxylase, hepatic monoox- Glomerular filtration rate, a-hANP, tubular 1092 ygenase system, persistent defects, site of action (dogs), 707 Hamed, A. T., Jandhyala, B. S. and Lok- phenytoin (rats), 68 Glucuronidation, pharmacokinetic studies, handwala, M. F.: Evaluation of the High, J., see Antonaccio, M. J., 378 acetaminophen disposition, mater- role of alpha-i and apha-2 adre- Hindlimb, resistance, alpha adrenoceptors nal-placental-fetal unit (sheep), 198 noceptors in the maintenance of neu- and (dogs), 599 Glutamic acid decarboxylase, enzyme mac- rogenic tone to the hindlimb vascu- Hinojosa, C. and Haywood, J. R.: Develop- tivation, retina vs. brain (rats), 508 lature, 599 ment of high sodium renal hypenten- Glutathione Hamon, M., see Bourgoin, S., 360 sion during chronic blockade of the conjugation, reduced hepatic energy state a-hANP, see Human atrial natriuretic poly- vascular effects of vasopressin, 492 peptide effects (rats), 457 Hinson, J. A. and Mays, J. B.: Covalent prevention of acetaminophen-induced Hansen, D. K. and Billings, R. E.: Effects binding of the phenacetin metabolite hepatotoxicity, N-acetyl-L-cysteine of nitrous oxide on macromolecu!ar p-nitrosophenetole to protein, 106 (mice), 54 content and DNA synthesis in rat Hippocampus Goldfarb, S., see Weiss, J., 969 embryos, 985 barbiturate effects (rats), 564 Goldstein, D. see Brown, J. H., 580 Hanson, G. R., see Sonsalla, P. K., 932 membranes, serotonin inhibition, forsko- Goppelt-Strube, M., see F#{246}rstermann, U., Harris, R. A., see Allan, A. M., 763 lin-stimulated adenylate cyclase 352 Harrison, J. H., Jr. and Jollow, D. J.: Role (guinea pigs, rats), 248 of aniline metabolites in aniline-in- Goto, K., see Saito, 713 Histamines Grace, A. A. and Bunney, B. S.: Induction duced hemolytic anemia, 1045 local anesthetics and, excess tachycardia Harsing, L. G., Jr., see Vizi, E. S., 701 of depolarization block in midbrain (dogs), 367 Hartley, C. J., see Chelly, J. E., 665 dopamine neurons by repeated ad- lung mediator release, reduced oxygen Hartmann, A., see Kiil, F., 327 ministration of haloperidol: Analysis tension, 8 using in vivo intracellular recording, Hattori, Y., Nakaya, H., Tohse, N. and release, organophosphate-induced, mast Kanno, M.: Vascular and cardiac ef- 1092 cells (rats), 839 fects of a new dihydropynidine deriv- Grandordy, B. M., Cuss, F. M., Sampson, A. Hoffer, B., see Contreras, P. C., 1101 ative, YC-170: A comparison with S., Palmer, J. B. and Barnes, P. J.: Hoffman, B. B., see Rosenbaum, J. S., 396 Bay K 8644, 670 Phosphatidylinositol response to Hoffmann, I. S., Talmaciu, R. K. and Cu- Haywood, J. R., see Hinojosa, C., 492 cholinergic agonists in airway smooth beddu, L. X.:Interactions between H2 blocker, pharmacological comparison, ci- muscle: Relationship to contraction endogenous dopamine and dopamine metidine and ranitidine (dogs), 587 and muscaninic receptor occupancy, agonists at release modulatory recep- Heart 273 tars: Multiple effects of neuronal up- antihistamines and local anesthetics, ex- Grant, A. 0., see Moorman, J. R., 159 take inhibitors on transmitter re- cess tachycardia (dogs), 367 Greenberg, D. A., Carpenter, C. L. and atrial muscle, pharmacodynamic interac- lease, 437 Messing, R. 0.: Depolarization-de- Holck, M., see Kozlowski, R., 1084 tions between quinidine and digoxin pendent binding ofthe calcium chan- Holthe, M. R., see Ku!, F., 327 (guinea pigs), 632 nel antagonist, (+)-[3H]PN200-iiO, Holtzman, S. G., see Finn, I. B., 542 beta adrenoceptor antagonists, antihyper- to intact cultured PC12 cells, 1021 Holtzman, S. G., see Locke, K. W., 990,997 tensive effects (rats), 372 Griffiths, R. R., see Lukas, S. E., 924 Hori, R., see Saito, H., 1071 calcium channel, oNCS-DHP inhibition Gross, G. J. and Daemmgen, J. W.: Benefi- of (guinea pig), 1084 Hosobuchi, Y., see Gilbeau, P. M., 974 cia! effects of two specific brady- Hruby, V. J., see Gulya, K., 720 inotropic and chronotropic actions, dihy- cardic agents AQ-A39 (Falipamil) Hubel, K. A. and Renquist, K. S.: Effect of dropyrides and (rabbits), 670 and AQ-AH 208 on reversible myo- isolated sinoatrial and atrioventricular neuropeptide Y on ion transport by cardial reperfusion damage in anes- nodes, dantrolene sodium, ischemia the rabbit ileum, 167 thetized dogs, 422 Huffman, W., see Mann, W. A., 401 model (rabbits, dogs), 206 Gross, G. J., see Eskinder, H., 515 stimulation ofmyofilament force, bepridil a-Human atnial natriuretic polypeptide, Gross, G. J., see Pelc, L. R., 113 (pigs), 502 synthetic, tubular site of action Grover, G. J., Tierney, M. A. and Weiss, H. sympathetic function, presynaptic regu- (dogs), 707 R.: Beta adrenoceptor control of the lation (guinea pigs), 447 Hydralazine, regional blood flow and, con- microvascular reserve in rabbit myo- sympathetic transmission, beta adre- scious state (dogs), 665 cardium, 868 noceptors, epinephrine and iso- Hydronephrotic cortical interstitial cells Gruetter, C. A. and Lemke, S. M.: Compar- proterenol effects (dogs), 334 eicosanoid synthesis (rabbits), 95 ison of endothelium-dependent re- Heart muscle, maitotoxin effects (guinea prostaglandin E, synthesis, verapamil ef- laxation in bovine intrapulmonary pigs, rats), 1077 fect (rabbits), 125 artery and vein by acetylcholine and Heart rate, vasopressin, sodium-dependent i2-Hydroxyeicosatetraenoic acid, insulin re- A23187, 1055 hypertension and (rats), 492 lease and, pancreatic islets (rats), 809 Guentert, T. W., Schmitt, M. and Defoin, Helgeson, E. A., see Newball, H. H., 839 P-Hydroxymercunibenzoic acid, insulin re- R.: Acceleration of the elimination of Hemolytic anemia, aniline-induced, aniline lease and, pancreatic islets (rats), tenoxicam by cholestyramine in the metabolites role in (rats), 1045 809, 819 dog, 295 Hepatocytes, exposed to carbon tetrachlo- 3-Hydroxy-3-methylglutaryl conezyme A Gulya, K., Gehlert, D. R., Wamsley, J. K., ride, cytosolic calcium (rats), 186 reductase, ketoconazole effects, Mosberg, H., Hruby, V. J. and Ya- Hepatotoxicity sterol synthesis, 905 mamura, H. I.: Light microscopic au- acetaminophen-induced, glutathione role 5-Hydroxytryptamine, see Serotonin toradiographic localization of delta in prevention, N-acetyl-L-cysteine Hynes, M. R., Banner, W., Jr., Yamamura, opioid receptors in the rat brain using (mice), 54 H. I. and Duckles, S. P.: Characteri- a highly selective bis-pencillamine ally! alcohol, liver lobule (rats), 1132, 1138 zation of muscarmnic receptors of the cyclic enkephalin analog, 720 Hess, E. J., Albers, L. J., Le, H. and Creese, rabbit ear artery smooth muscle and Gundlach, A. L., see Largent, B. L., 739 E.: Effects of chronic SCH23390 endothelium, 100 1986 Index 1151

Hypercalcemia, experimental, WR-2721 ef- verapamil and prostaglandin E, airway mine H2-receptor agonist, to cimeti- fects (rats), 969 smooth muscle relaxation (dogs), 76 dine and ranitidine, 587 Hyperserotoninemia, gastrointestinal ef- o-Isothiocyanate dihydropynidine, calcium Kau, S. T., see Li, J. H.-Y., 415 fects, ketanserin, atropine, and meth- channel inhibition (guinea pig), 1084 Kauffman, F. C., see Bath, M. Z., 1138 ysergide in (dogs), 536 Ito, K., see Yukimura, T., 707 Kauffman, F. C., see Belinsky, S. A., 7835 Hypertension Iyengar, S., Kim, H. S. and Wood, P. L.: Kauker, M. L. and Nasjletti, A.: Segmental beta adrenoceptor antagonists, antihyper- Kappa opiate agonists modulate the nephron function in rats treated with tensive effects (rats), 372 hypothalamic-pituitary-adrenocorti- aprotinin, an inhibitor of kallikrein, one-kidney, figure-8, vasopressin and cal axis in the rat, 429 i55 (rats), 492 Iyengar, S., see Rinehart, R. K., 178 KB-944, novel calcium antagonist, myocar- pheochromocytoma, aortic contraction in dial ischemia (dogs), 113 (rats), 396 Kelatorphan, release of methionine-en- spontaneous, carbocyclic adenosine in Jacobson, A. E., see Contreras, P. C., 1101 kephalin-like material, spinal cord (rats), 954 Jaffe, B. M., Ferrara, A. and Sherlock, D. (rats), 360 Hypoxia J.: Comparative effects of ketanserin, Kenny, A. D., see Hall, G. E., 778 chemotactic factor-induced transcutane- atropine and methysergide on the Ketanserin ous, ibuprofen and methylpredniso- gastrointestinal effects of hypersero- alpha-2 adrenoceptors, question of exist- lone effects (rabbits), 453 toninemia in the awake dog, 536 ence, tail arteries (rats), 267 Jalife, J., see 206 lung mediator release, 8 Davidenko, J., gastrointestinal effects of hyperserotoni- James, D. W., see Ward, S. J., 625 nemia and (dogs), 536 James, M. see Shiverick, K. T., 1108 0., Ketoconazole, cholesterol synthesis and, Ibuprofen, chemotactic factor-induced Jandhyala, B.S., see Hamed, A. T., 599 transcutaneous hypoxia and (rab- 905 Jardine, I., see Low, J. E., 39 Ketocyclazocine, psychopharmacology of, bits), 453 Jasinski, D., see Kumor, K. M., 960 960 IC! 174864, opioid agonist activity of (mice), Jaw-opening reflex, -nociceptive, alpha ad- Kiang, J. G., see Wei, E. T., 783 769 renoceptor modulation of (rats, rab- Ileum Kidney bits), 576 cells, anoxia, calmodulin binding drugs calcium channel, oNCS-DHP inhibition Jejunum, contractility, after chronic abla- (rabbits), 119 of (guinea pig), 1084 tion, myenteric plexus (rats), 372 circulation, hydralazine effects, conscious CH-38083 effects (guinea pigs), 701 Jim, K. F., Macia, R. A. and Matthews, W. state (dogs), 665 neuropeptide Y, effect on ion transport D.: Role of receptor reserve in the cortex, lipid peroxidation, gentamicin-in- (rabbits), 167 inhibition of alpha-i adrenoceptor- duced (rats), 83 opioid agonist activity (guinea pigs), 625 mediated pressor responses by cal- drug metabolism, chemical carcinogenesis Imipramine, injected into amygdala, behav- cium antagonists in the pithed rat, 89 (rats), 457 ioral responses and (rats), 758 Johnson, J. D., see Solaro, R. J., 502 epithelial cell, gentamicin transport, 1071 Indomethacin Johnson, K. M., see Snell, L. D., 938 failure, pharmacokinetics of diflunisal milrinone inhibition of, lung (guinea Johnson, M. D., Wang, J. K. T., Morgan, J. (rats), 978 pigs), 874 I. and Spector, S.: Downregulation of hemodynamics water excretion and, kidney, 653 [3H]RO5-4864 binding sites after ex- carbocyclic adenosine in (rats), 954 Inotropic actions, desethyl-N-acetylpro- posure to peripheral-type benzodi- a-hANP site of action (dogs), 707 cainamide (dogs), 893 azepines in vitro, 855 prostaglandin B2 synthesis, verapamil ef- Insulin Johnson, R. E., see Kumor, K. M., 960 feet, hydronephrotic cortical intersti- release, p-hydroxymercuribenzoic acid ef- Johnson, S., see Contreras, P. C., llOi tial cells (rabbits), 125 Jollow, D. J., see Harrison, J. J., Jr., 1045 fects, islets (rats), 809 segmental nephron function, aprotinin Jones, M. E., see Meffin, P. J., 280 urinary eicosanoid excretion and, experi- treatment (rats), 155 mental diabetes (rats), 606 Jones, M. E., Sallustio, B. C., Purdie, Y. J. and Meffin, P. J.: Enantioselective sodium/potassium-ATPase, transport Intestinal motility rate, transcellular NaCl reabsorption cholinergic neuron mediation of (rats), disposition of 2-arylpropionic acid (dogs), 327 594 nonsteroidal anti-inflammatory drugs. II. 2-Phenylpropionic acid pro- tubules, bumetanide action in (mice), 407 nervous control of (guinea pigs), 1114 Xii!, F., Hartmann, A., Langberg, H., Se- tein binding, 288 Inui, K.-!., see Saito, H., 1071 jersted, 0. M. and Holthe, M. R: Iodocyanopindolol, beta adrenergic recep- Josepovitz, C., see Ramsammy, L. S., 83 Joshi, U., see Atchison, W. D., 618 Renal Na,K-adenosine triphospha- tars, radioligand selectivity, quanti- tase transport rate limits transcel!u- tative analysis, 46 lar NaCI reabsorption in distal neph- Iodohydroxybenzylpindolol, beta adrenergic Kalivas, P. W., Richardson-Carlson, R and rons of volume-expanded dogs, 327 receptors, radioligand selectivity, Duffy, T.: Neuromedin N mimics the Killam, E. K., see Paule, M. G., 32 quantitative analysis, 46 actions of neurotensin in the ventral Kim, H. S., see Iyengar, S., 429 lodopindolol, beta adrenergic receptors, tegmental area but not in the nucleus Kimura, S., see Saito, A., 713 radioligand selectivity, quantitative accumbens, 1126 Kimura, T., see Yorikane, R, 334 analysis, 46 Kal!ikrein King, L. W., see Lertora, J. J. L., 893 Iprindole, injected into amygdala, behav- renal, segmental nephron function, apro- Kinins, segmental nephron function, apro- ioral responses and (rats), 758 tinin treatment (rats), 155 tinin treatment (rats), 155 IPS-339, epinephrine and isoproterenol, urinary, experimental diabetes mellitus Kinter, L. B., see Mann, W. A., 401 sympathetic transmission, heart and (rats), 606 Klaassen, C. D., see Dulls, R. L, 463 (dogs), 334 Kaloyanides, G. J., see Ramsammy, L. S., Klemfuss, H. and Adler, M. W.: Autonomic Ischemia, isolated sinoatrial and atrioven- 83 mechanisms for morphine and am- tricular nodes, dantrolene sodium, Kanda, A., see Yorikane, R., 334 phetamine mydriasis in the rat, 788 electrophysiological actions (rabbits, Kangawa, K., see Yukimura, T., 707 Kobayashi, M., Kondo, S., Yasumoto, T. dogs), 206 Kanno, M., see Hattoni, Y., 670 and Ohizumi, Y.: Cardiotoxic effects Ishikawa, T., see Saito, A., 713 Kaplan, H. R., see Ryan, M. J., 473 of maitotoxin, a principal toxin of Isoproterenol Kapocsi, J., see Vizi, E. S., 701 seafood poisoning, on guinea pig and epinephrine and IPS-339, sympathetic Katona, P. G., see Rigel, D. F., 367 rat cardiac muscle, 1077 transmission, heart (dogs), 334 Katz, L. B., Scott, C. K. and Shriver, D. A.: Kocher, T., see Kumor, K. M., 960 stimulation of fat cells, cyclic AMP and Pharmacological comparison of ORF Kondo, S., see Kobayashi, M., 1077 lipolysis relations in (rats), 659 17910, a potent, long-acting hista- Koslo, R. J., Burks, T. F. and Porreca, F.: 1152 Index Vol. 238

Centrally administered bombesin a!- tor neurotransmitter in the rabbit Lung fects gastrointestinal transit and co- basilar artery, 880 angiotensin-converting enzyme inhibitor, lonic bead expulsion through supra- Li, J. H.-Y., Zuzack, J. S. and Kau, S. uptake of N-[i(S)-carboxy-(4-OH-3- spinal mechanisms, 62 T.:Effects of detergents on sodium ‘I-phenyl)ethyl-L-ala-L-pro (rab- Kosobud, A. and Crabbe, J. C.: Ethanol transport in toad urinary bladder, bits), 14 withdrawal in mice bred to be genet- 415 mediator release, reduced oxygen tension, ically prone or resistant to ethanol Liang, B. T. and Molinoff, P. B.: Beta ad- 8 withdrawal seizures, 170 renergic receptor subtypes in the milrinone effects, contractile response Kozlowski, R., Ehrhard, P., Fischli, W., Os- atria: Evidence for close coupling of (guinea pigs), 874 terrieder, W. and Holck, M.: o-Iso- beta-i and beta-2 adrenergic recep- Luteinizing hormone thiocyanate dihydropynidine (oNCS- tors to adenylate cyclase, 886 naloxone effects on, hyposensitivity to, DHP), a long-acting reversible inhib- Lichtenstein, L. M., see Peters, S. P., 8 male (rats), 1063 itor of the Ca channel, 1084 Lidocaine, pH potentiation, drug pK, so- 6-9-tetrahydrocannabinol treatment ef- Kraemer, F. B. and Spilman, S. D.: Effects chum channel blockade in ventricular fects, chronic prepuberta! treatment of ketoconazole in cholesterol syn- myocardium (guinea pigs), 159 of female (rats), 1034 thesis, 905 Lin, J. H., Ulm, E. H. and Duggan, D. E.: Ly 171555, supersensitivity, apomorphine, Kragh, R., see Carroll, M. E., 1 Possible mechanisms for reduced rotational behavior (mice), 242 Kroeger, E. A., see Bergen, J., 679 plasma clearance of diflunisal in rat LY 281217, carboxypeptidase degradation Kumor, K. M., Haertzen, C. A., Johnson, R. experimental renal failure, 978 product, opioid agonist activity of IC! E., Kocher, T. and Jasinski, D.: Hu- Ling, K.-Y., see Ramsammy, L. S., 83 174864 (mice), 769 man psychopharmacology of ketocy- Lipid peroxides, hepatotoxicity and, liver LY83583, carbachol and forskolin interac- clazocine as compared with cyclazo- lobule (rats), 1138 tion, isolated cardiac preparations cine, morphine and placebo, 960 Lipids, peroxidation and toxicity, gentami- (rabbits), 313 Kwang, J. K. T., see Johnson, M. D., 855 cm-induced, diphenyl-phenylenedi- Lysergic acid diethylamide, serotonin inhi- amine effects (rats), 83 bition, forskolin-stimulated adenyl- Lipolysis, cyclic AMP relations, fat cells, ate cyclase, hippocampal membranes Lac, S. T., see Carroll, M. E., 1 isoproterenol and forskolin effects (guinea pigs, rats), 248 Lai, W. S., see El-Fakahany, E. E., 554 (rats), 659 Lysolecithin acyltransferase, acyl-coenzyme Lakshmi, V. M., see Spry, L., 457 Liposomes, novel cyclosporine binding as- A inhibitors, endothelium-derived Lambert, C., Vermeulen, M., Cardinal, R. say (mice), 39 vascular relaxing factor (rabbits), 352 and Nadeau, R.: Effect of the induc- Lipoxygenase Lysophosphatidylcholine, stimulus-secre- tion of amiodarone biotransforma- insulin release and, pancreatic islets tion coupling and, insulin release, is- tion on ventricular refractory periods (rats), 809 lets (rats), 819 in rats, 307 stimulus-secretion coupling, insulin re- Lysophospholipids Lane, B. P., see Ramsammy, L. S., 83 lease and (rats), 819 insulin release and, pancreatic islets Langberg, H., see Kiil, F., 327 Liver (rats), 809 Lanosterol, synthesis, ketoconazole effects, hepatotoxicity, allyl alcohol (rats), 1132, stimulus-secretion coupling and, insulin 905 release, pancreatic islets (rats), 819 1138 Largent, B. L., Gundlach, A. L. and Snyder, monooxygenase system, persistent de- S. H.: Pharmacological and autora- fects, phenytoin (rats), 68 diographic discrimination of sigma Maayani, S., see De Vivo, M., 248 Locke, K. W. and Holtzman, S. G.: Behav- and phencyclidine receptor binding Macdonald, R. L., see McLean, M. J., 727 sites in brain, with (+)-[3H]SKF ioral effects of opioid peptides selec- Macia, R. A., see Jim, K. F., 89 10,047, (+)-[3HJ-3-[3-hydroxy- tive for mu or delta receptors. I. Mor- MacLeod, K. M. and Diamond, J.: Effects phenylj-N-(1-propyl)piperidine and phine-like discriminative stimulus of the cyclic GMP lowering agent [3HJ-1-[1-(2-thienyl)cyclohexyljpi- effects, 990 LY83583 on the interaction of car- peridine, 739 Locke, K. W. and Holtzman, S. G.: Behav- bachol with forskolin in rabbit iso- Larrey, D., see Letteron, P., 685 ioral effects of opioid peptides selec- lated cardiac preparations, 313 Le, H., see Hess, E. J., 846 tive for mu or delta receptors. II. Lo- Macromolecular synthesis, nitrous oxide ef- Le Bars, D., see Bourgoin, S., 360 comotor activity in nondependent feds, embryos (rats), 985 Loch, G. M., see Shapiro, B. H., 68 and morphine-dependent rats, 997 Maderazo, E. G., Breaux, S. P. and Woron- Lee, N. M., see Fang, F. G., 1039 Locomotor activity ick, C. L.: Protective effects of ibu- Lee, N. M., see Gilbeau, P. M., 974 chronic SCH23390, dopamine receptors profen and methylprednisolone on Leibold, L., see Picker, M., 529 and (rats), 846 chemotactic factor-induced transcu- Lemke, S. M., see Gruetter, C. A., 1055 opioid peptide effects (rats), 990,997 taneous hypoxia, 453 Lepore, R. D., see Perrone, M. H., 389 stimulation, caffeine and (rats), 542 Maggi, C. A., Giuliani, S., Manzini, S., San- Lertora, J. J. L. and King, L. W.: Cardio- Lokhandwala, M. F., see Alkadhi, K. A., 547 ticioli, P. and Meli, A.: Motor effect vascular actions and pharmacoki- Lokhandwala, M. F., see Hamed, A. T., 599 of neurokinins on the rat duodenum: netics of desethyl-N-acetylprocain- London, E. D., see Szikszay, M., 192 Evidence for the involvement of sub- amide in the dog, 893 Long, R. M. and Moore, L: Elevated cyto- stance K and substance P receptors, Lessor, R. A., see Contreras, P. C., 1101 solic calcium in rat hepatocytes ex- 341 Letteron, P., Descatoire, V., Larrey, D., Ti- posed to carbon tetrachloride, 186 Maggi, C. A., Santicioli, P., Giuliani, S., nel, M., Geneve, J. and Pessayre, D.: Longhurst, P. A. and Belis, J. A.: Abnor- Regoli, D. and Meli, A.: Activation of Inactivation and induction of cyto- malities of rat bladder contractility micturition reflex by substance P and chrome P-450 by various psoralen de- in streptozotocin-induced diabetes substance K: Indirect evidence for rivatives in rats, 685 mellitus, 773 the existence of multiple tachykinin Leukocytes LoPresti, D., see Ward, S. J., 625 receptors in the rat urinary bladder, chloroquine, mechanisms of cell associa- Low, J. E. and Jardine, I.: A novel cyclo- 259 tion, 302 sporine binding assay, 39 Maitotoxin, cardiotoxic effects, cardiac polymorphonuclear, oxygen metabolite Lucchesi, B. R., see Simpson, P. J., 497 muscle (guinea pigs, rats), 1077 generation, doxorubicin and doxo- Lukas, S. E., Brady, J. V. and Griffiths, R Major, T. C., see Ryan, M. J., 473 rubicinol-induced alterations, 19 R.: Comparison of opioid seif-injec- Makman, M. H., see Cubells, J. F., 508 Leukotrienes, lung mediator release, re- tion and disruption of schedule-con- Mann, W. A., Stassen, F., Huffman, W. and duced oxygen tension, 8 trolled performance in the baboon, Kinter, L. B.: Mechanism of action Levitt, B. and Duckles, S. P.: Evidence 924 and structural requirements of vaso- against serotonin as a vasoconstric- Lund, D. D., see Schmid, P. G., 447 pressin analog inhibition of trans- 1986 Index 1153

epithelial water flux in toad urinary N-Methylscopolamine Mosberg, H., see Gulya, K., 720 bladder, 401 cardiac muscarinic receptors (chicks), 580 Mueller, R. A., see Duncan, G. E., 758 Mansbach, R. S., see Barrett, J. E., 1009 multiple binding affinities, brain muses- Murray, D. L., see Stupecky, G. L., 802 Manzini, S., see Maggi, C. A., 341 rime acetylcboline receptors (rats), Muscarinic receptors, see Receptors Marley, R. J., Miner, L. L., Wehner, J. M. 554 Muscle, smooth and Collins, A. C.: Differential effects Methylxanthines, caffeine, locomotor activ- airway of central nervous system depres- ity and (rats), 542 adrenoceptor-mediated mechanical ne- sants in long-sleep and short-sleep Methysergide, gastrointestinal effects of hy- sponse (dogs), 679 mice, 1028 perserotoninemia and (dogs), 536 phosphatidylinositol response, cholin- Marwah, J., see Curtis, A. L., 576 Metz, S. A.: p-Hydroxymercuribenzoic acid ergic agonists (cattle), 273 Marwood, J. F., Chapman, K. L. and Stokes, inhibits arachidonic acid esterifica- relaxation, verapamil, isoproterenol G. S.: Studies that question the exist- tion in two distinct pools and stimu- and prostaglandin E (dogs), 76 ence of a4,ha-2 adrenoceptors in tail lates insulin release in intact rat is- aortic, contraction, desensitization of, arteries of normotensive Sprague- lets, 809 pbeochromocytoma and (rats), 396 Dawley rats, 267 Metz, S. A.: Putative roles for lysophospho- ear artery and endothelium, muscaninic Masaki, T., see Saito, A., 713 lipids as mediators and lipoxygenase- receptors, characterization (rabbits), Mason, N., see Cohen, M. L., 860 mediated metabolites of arachidonic 100 Mast cells, histamine release, organophos- acid as potentiators of stimulus-se- vascular phate-induced (rats), 839 cretion coupling Dual mechanisms alpha-1,2 adrenoceptors, effect of cool- Mathias, N. P., see Ryan, M. J., 473 of p-hydroxymercunibenzoic acid-in- ing (dogs), 139 Matsuo, H., see Yukimura, T., 707 duced insulin release, 819 alpha adrenoceptors, Schild plot limi- Matthews, W. D., see Jim, K. F., 89 Meyer, E. R., see Cicero, T. J., 1063 tations, 237 Mattila, J. and Bu#{241}ag,R. D.: Sympathetic Microvascular reserve, myocardium, beta alpha-i and alpha-2 adrenoceptors, re- vasoconstriction and renin secretion adrenoceptor control of(rabbits), 868 sponse coupling (dogs), 131 cause pressor responses to thyrotro- Migrating myoelectric complex, gastrointes- Mydniasis, morphine and amphetamine, pin-releasing hormone in rats, 232 tins!, nervous control of (guinea autonomic mechanisms (rats), 788 Mayersohn, M., see Woodworth, J. R., 900 pigs), 1114 Myenteric plexus, after chronic ablation, je- Mays, J. B., see Hinson, J. A., 106 Miller, B. T., see Cicero, T. J., 1063 junal contractility (rats), 372 McCall, D. E., see Chiu, A. T., 224 Miller, T. B., see Smith, E. R., 26 Myocardium McDonough, P. M., Wetzel, G. T. and Mills, E., Bruckert, J. W. and Smith, P. G.: isehemia Brown, J. H.: Further characteriza- Development of adrenergic and non- beneficial effects of bradycardic agents, tion ofthe presynaptic alpha-i recep- adrenergic pressor mechanisms in anesthesia and (dogs), 422 tar modulating [3HJACh release from rats sympathectomized from birth, novel calcium antagonist (dogs), 113 rat atnia, 612 1014 microvascular reserve, beta adrenoceptor McGiff, J. C., see Quilley, J., 606 Milnor, W. R.: Limitations of Schild plots control of (rabbits), 868 McGonigle, P., see Neve, K. A., 46 in a two-receptor system: Alpha adre- ventricular, sodium channel blockade, McLean, M. J. and Macdonald, R. L.: Car- noceptors of vascular smooth muscle, drug pI(. and pH potentiation bamazepine and 10,11-epoxycarba- 237 (guinea pigs), 159 mazepine produce use- and voltage- Milrinone, contractile response and, lung Myofilaments, cardiac, stimulation by be- dependent limitation of rapidly firing (guinea pigs), 874 pridil (pigs), 502 action potentials of mouse central Miner, L. L., see Marley, R. J., 1028 neurons in cell culture, 727 Miyazaki, M., see Teds, N., 319 Meffin, P. J., Sallustio, B. C., Purdie, Y. J. Molinoff, P. B., see Liang, B. T., 886 Nadeau, R., see Lambert, C., 307 and Jones, M. E.: Enantioselective Molinoff, P. B., see Neve, K. A., 46 Nakaki, T., see Roth, B. L., 480 disposition of 2-arylpropionic acid Monoamine oxidase, formation of 1-methyl- Nakaya, H., see Hattori, Y., 670 nonsteroidal anti-inflammatory 4-phenyl-1,2,3,6-tetrahydropyridine, Naloxone, opiate withdrawal-induced by- drugs. I. 2-Phenylpropionic acid dis- brain (rats), 648 posensitivity, serum luteinizing hor- position, 280 Monohydroxy metabolites, phencycidine, mone, male (rats), 1063 Meffin, P. J., see Jones, M. E., 288 disposition kinetics (dogs), 900 Naltrexone Meli, A., see Maggi, C. A., 259, 341 Monooxygenase, hepatic system, persistent effects, cocaine self-injection (rats), 1 Mertz, T. E., see Ryan, M. J., 473 defects, phenytoin (rats), 68 opioid peptide antagonism (rats), 990,997 Messing, R. 0., see Greenberg, D. A., 1021 Moore, D. H., Abel, P. W., Rinard, G. A., Naseer, K., see Allen, D. 0., 659 Metabolic/excretory coupling, renal, nitro- Puckett, A. M. and Walter, J. B.: Nasjletti, A., see Kauker, M. L., 155 furothiazole carcinogens (rats), 457 Regional differences in relaxation of Neale, R. F., see Rinehart, R. K., 178 Metaphit, acy!ating ligand for receptors electric field-stimulated canine air- Nephrectomy, sympathetic vasoconstriction (rats), 1101 way smooth muscle by verapamil, iso- and renin secretion, pressor re- Met-enkephalin, release, kelatorphan, proterenol and prostaglandin E,, 76 sponses, thyrotropin-releasing hor- spinal cord (rats), 360 Moore, L, see Long, R. M., 186 mone (rats), 232 Methamphetamine, dopamine receptor sub- Moorman, J. R., Yes, R., Bjornsson, T., Nephrons, distal, renal sodium/potassium- types in, monoamine systems (rats), Starmer, C. F., Grant, A. 0. and ATPase transport rate, NaCl reab- 932 Strauss, H. C.: pI( does not predict sorption (dogs), 327 Methionine synthetase, nitrous oxide anes- pH potentiation of sodium channel Nerve terminals, calcium entry, suppression thesia effects, embryos (rats), 985 blockade by lidocaine and W6211 in by methylmercury (rats), 618 N-Methyl-D-aspartate, phencyclidine and, guinea pig ventricular myocardium, Neuroblastoma cells, muscarinic cholinergic striatum (rats), 938 159 receptors in, short-term desensitiza- 3-Methylcholanthrene, placental activity Morgan, J. I., see Johnson, M. D., 855 tion (mice), 916 and (rats), 1108 Morphine Neurogenic inflammation, corticotropin-re- Methylmercury, block, end-plate potential mydriasis, mechanism (rats), 788 leasing factor and, paw (rats), 783 (rats), 618 neurogenic plasma extravasation and, Neurogenic tone, hindlimb vasculature, a!- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyri- paw (rats), 783 p1w adrenoceptors and (dogs), 599 dine, reactive metabolite, brain psychopharmacology of ketocyclazocine Neurokinins, motoreffect, duodenum (rats), (rats), 648 compared with, 960 341 Methylprednisolone, chemotactic factor-in- verapamil interactions, calcium antago- Neuromedin N, ventral tegmental area, duced transcutaneous hypoxia and nists, physiological parameters 1126 (rabbits), 453 (rats), 192 Neuromuscular transmission, methyhner- 1154 Index Vol. 238

cury inhibition of, nerve terminals turnover, CH-38083 effects (guinea pigs, Peeters, P. A. M., see Raghoebar, M., 302 (rats), 618 rats, mice), 701 Pelc, L. R., Gross, G. J. and Warltier, D. C.: Neurons, central, reduction of repetitive fir- Nucleus accumbens, neuromedin N actions, Effects of KB-944, a novel calcium ing by carbamazepine (mice), 727 1126 antagonist, in several models of ca- Neuropeptides, peripheral, intestinal my- nine myocardial ischemia, 113 oelectric activity (guinea pigs), 1114 Oates, R., see Davidenko, J., 206 Penney, J. B., Jr., see Ciliax, B. J., 749 Neuropeptide Y, effect on ion transport, Obesity, verapamil dynamics and (rats), 642 Pentobarbital, dependence and tolerance, ileum (rabbits), 167 Ode, R. P., see Schmid, P. G., 447 dosing frequency (cats), 1004 Neurotensin, actions, ventral tegmental O’Donohue, T. L., see Contreras, P. C., 1101 Peptidase, kelatorphan and, Met-enkepha- area, 1126 Ohiztimi, Y., see Kobayashi, M., 1077 lin-like release, spinalcord (rats), 360 Neurotransmission Okamoto, M, Rao, S. and Walewski, J. L.: Perrone, M. H., Lepore, R. D. and Sham, sympathetic Effect of dosing frequency on the de- W.: Identification and characteriza- beta adrenoceptors, cardiovascular re- velopment of physical dependence tion of substance P receptors on sponsiveness (rats), 148 and tolerance to pentobarbital, 1004 LRM55 glial cells, 389 beta adrenoceptors, heart (dogs), 334 Okamura, T., see Toda, N., 319 Pessayre, D., see Letteron, P., 685 Neurotransmitters Olsen, K., see Contreras, P. C., 1101 Peters, S. P., Lichtenstein, L. M. and Ad- release, presynaptic alpha-i receptor Olsen, R. W., see Dunwiddie, C. W., 564 kinson, N. F., Jr.: Mediator release modulation of, atria (rats), 612 Olson, R. D., see Nielson, C. P., 19 from human lung under conditions of vasoconstrictor, basilar artery (rabbits), Olszewski, B. J., see Ryan, M. J., 473 reduced oxygen tension, 8 880 Operant conditioning, anticonvulsant Petrack, B., see Rinehart, R. K., 178 Neutrophils, stimulated, ibuprofen and, drugs, modulation by external dis- pH, potentiation, drug pK, sodium channel complications (rabbits), 453 criminative stimulus (pigeons), 529 blockade in ventricular myocardium Neve, K. A., McGonigle, P. and Molinoff, Opiates (guinea pigs), 159 P. B.: Quantitative analysis of the hypothalamic-pituitary-adrenal axis and Pharmacokinetics, diflunisal, renal failure selectivity of radioligands for sub- (rats), 429 (rats), 978 types of beta adrenergic receptors, 46 neuroendocrine, anterior pituitary hor- Phenacetin, metabolite, covalent binding to Newball, H. H., Donlon, M. A., Procell, L. mones (primate), 974 protein (rats, mice), 106 R, Helgeson, E. A. and Franz, D. R.: supraspinal analgesic effects, mu receptor Phencyclidine Organophosphate-induced histamine action (mice), 1039 receptors, see Receptors release from mast cells, 839 withdrawal-induced hyposensitivity, nal- excitatory amino acids and, stniatum Newman, T., see Carroll, M. E., 1 oxone, serum LH, male (rats), 1063 (rats), 938 Nicotine Opioid, self-injection, disruption of sched- monohydroxy metabolites of, disposition jejunal contractility, after chronic abla- ule-controlled performance and (ha- kinetics (dogs), 900 tion, myenteric plexus (rats), 372 boons), 924 p-Phenetidine, covalent binding to protein stimulatory effects, rapid desensitization Opioid agonists (rats, mice), 106 of, plasma adrenocorticotropin and activity of IC! 174864 (mice), 769 Phenobarbita!, central nervous system de- prolactin (rats), 486 mu- and delta-selective, ileal preparation pressant, long- and short-sleep Nielson, C. P., Brenner, D. and Olson, R. and (guinea pigs), 625 (mice), 1028 D.: Doxorubicin and doxorubicinol- neurogenic plasma extravasation and, Phenylephnine induced alterations in human poly- paw (rats), 783 a!pha-1,2 adrenoceptors morphonuclear leukocyte oxygen me- Opioid peptides effect of cooling, saphenous and femo- tabolite generation, 19 behavioral effects ral veins (dogs), 139 Nies, A. S., see Schwertschlag, U., 653 morphine-like, 997 response coupling, saphenous and fern- Nifedipine, receptor reserve and calcium an- mu and delta receptors (rats), 990 oral veins (dogs), 131 tagonists, alpha-i adrenoceptors ORF 17910, pharmacological comparison, alpha-2 adrenoceptors, question of exist- (rats), 89 cimetidine and ranitidine (dogs), 587 ence, tail arteries (rats), 267 Nitrendipine, serotonin contraction and, Organophosphate, histamine release in- Phenylhydroxylamine, toxicity, hemolytic uterus and jugular vein (rats), 860 duced by, mast cells (rats), 839 anemia (rats), 1045 5-Nitrofuran carcinogens, metabolism, Osborne, J. J., see Cohen, M. L., 769 2-Phenylpropionic acid, 2-arylpropionic bladder (rats), 457 Osterrieder, W., see Kozlowski, R., 1084 acid, enantioselective disposition Nitrofurothiazole carcinogens, metabolism, Ouabain (rabbits), 280, 288 bladder (rats), 457 prostatic secretion, drug-modified ion Phenytoin Nitroglycerin, block, alpha-2 adrenoceptors transport (dogs), 26 frequency-dependent actions, Purkinje fi- (dogs), 515 renal sodium/potassium-ATPase trans- bers (dogs), 794 p-Nitrosophenetole, covalent binding to port rate, tnansce!lu!ar NaCl reab- hepatic monooxygenase system, persist- protein (rats, mice), 106 sorption (dogs), 327 ent defects (rats), 68 Nitrous oxide, macromolecular content and Owens, S. M., see Woodworth, J. R., 900 Pheochromocytoma, aortic smooth muscle DNA synthesis, embryos (rats), 985 contraction, desensitization of (rats), Nociception, jaw-opening reflex, alpha ad- Palermo, N. J., see Smith, E. R., 26 396 renoceptor modulation of (rats, rab- Palmer, J. B., see Grandordy, B. M., 273 Phorbol esters, phosphoinositide metabo- bits), 576 Palmier, M. 0., see Danon, A., 95 lism and, serotonin (rats), 480 Nomifensine, drug interactions, autorecep- Pancreatic islets, insulin release, p-hydrox- Phosphatidylinositol, response to cholin- tore (rabbits), 437 ymercuribenzoic acid-induced (rats), ergic agonists, airway smooth muscle Nonsteroidal anti-inflammatory drugs, 809, 819 (cattle), 273 water excretion and, kidney, 653 Paraldehyde, central nervous system de- Phosphoinositide, metabolism, phorbol es- Nordihydroguaiaretic acid, endothelium-de- pressant, long- and short-sleep ter effects, serotonin (rats), 480 rived relaxing factor, acyl-coenzyme (mice), 1028 Phospholipase A2, insulin release and, pan- A:lysolecithin acyltransferase inhib- Parathyroid hormone, bone resorption in- creatic islets (rats), 809 itors (rabbits), 352 duced by (mice), 778 Phospholipase C, phorbol esters and, phos- Norepinephrine Paule, M. G. and Killam, E. K.: Behavioral phoinositide turnover (rats), 480 alpha-1,2 adrenoceptors, effect of cooling, toxicity of chronic ethosuximide and Physostigmine, jejunal contractility, after saphenous and femoral veins (dogs), sodium valproate treatment in the chronic ablation, myenteric plexus 139 epileptic baboon, Papio papio, 32 (rats), 372 Schild plot limitations, alpha adrenocep- PC12 cells, depolarization-dependent bind- Piccardi, M. P., see Corsini, G. U., 648 tors, vascular smooth muscle, 237 ing, calcium channelantagonist, 1021 Picker, M., Leibold, L., Endaley, B. and 1986 Index 1155

Poling, A.: Modulation of the behav- covalent binding, phenacetin metabolite antihypertensive activity of Cl-926 ioral effects of anticonvulsant drugs (rats, mice), 106 (rats), 473 by an external discriminative stimu- extravasation, corticotropin-releasing pheochromocytoma, aortic contraction lus in the pigeon, 529 factor and, paw (rats), 783 in (rats), 396 Pimozide, serotonin contraction and, uterus Psoralens, effects on cytochrome P-450 threshold synergism, thoracic aorta and jugular vein (rats), 860 (rats), 685 (rabbits), 802 Pintus, S., see Corsini, G. U., 648 Psychopharmacology, ketocyclazocine, 960 alpha-i Pirenzepine, receptor subtypes, brain, N- Puberty, tolerance to luteinizing hormone acetylcholine release and, atria (rats), methylscopolamine binding to (rats), and prolactin, female, #{246}-9-tetrahy- 612 554 drocannabinol and (rats), 1034 antihypertensive activity of Cl-926 Pitt, B. R., see Turnin, M., 14 Puckett, A. M., see Moore, D. H., 76 (rats), 473 Pituitary hormones, anterior, dynorphin Pulmonary circulation, vasoconstriction, a!- pheochromocytoma, aortic contraction and (primate), 974 pha-1,2 adrenoceptors, evaluation in (rats), 396 Placenta (dogs), 217 ‘y-aminobutyric acid, barbiturate effects, Pulmonary vessles, endothelium-dependent ethoxyresorufin-O-deethylase activity in brain (mice), 763 relaxation, acetylcholine and A23187, autoreceptors, dopamine interactions (rats), 1108 1055 (rabbits), 437 transfer, pharmacokinetic studies, acet- Pupil, dilation, morphine and amphetamine benzodiazepine aminophen disposition (sheep), 198 effects (rats), 788 antipunishment actions of buspirone Plasma renin, beta adrenoceptor antago- Purdie, Y. J., see Jones, M. E., 288 fists, antihypertensive effects (rats), and (pigeon), 1009 Purdie, Y. J., see Meffin, P. J., 280 regulation, imaging (rats), 739 372 Purdy, R. E., see Stupecky, G. L., 802 beta, to adenylate cyclase, atria (dogs), Plasminogen activator, epithelial tissue Purkinje fibers, antiarrhythmic actions of evaluation, thrombolytic agent, ye- 886 phenytoin (dogs), 794 DA1, activation by dopamine or fenoldo- nous thrombosis (rabbits), 254 pam (rats), 547 Platelets, CGS 13080 effects, coronary ar- delta opioid, localization in brain (rats), tery thrombosis (dogs), 497 Quilley, J. and McGiff, J. C.: Influence of 720 Poling, A., see Picker, M., 529 insulin on urinary eicosanoid excre- dopamine Polyaromatics, induction of ethoxyresoru- tion in rats with experimental dia- D1 and D2, SCH23390 effects (rats), 846 fin-O-deethylase, placental tissue betes mellitus, 606 methamphetamine and, monoamine (rats), 1108 Quinidine, interactions with digoxin, heart 632 systems (rats), 932 Porreca, F., see Koslo, R. J., 62 atrial muscle (guinea pigs), Quinpirole stress effects, prefrontal cortex (rats), Prazosin chronic SCH23390, dopamine receptors 693 alpha- 1,2 adrenoceptors, response cou- and (rats), 846 mu, supraspinal opiate analgesia (mice), pling, saphenous and femoral veins dopamine or fenoldopam and, cyclic AMP 1039 (dogs), 131 levels (rats), 547 multiple tachykinin, micturition reflex, alpha-2 adrenoceptors, question of exist- Quinuclidinyl benzilate substance P and K activation (rats), ence, tail arteries (rats), 267 cardiac muscaninic receptors (chicks), 580 259 Schild plot limitations, alpha adrenocep- phosphatidylinositol response, cholin- muscarinic tars, vascular smooth muscle, 237 ergic agonists, airway smooth muscle brain acetylcholine, N-methylscopo- sympathetic vasoconstriction and renin (cattle), 273 lamine binding to (rats), 554 secretion, pressor responses, thyro- cardiac, binding (chicks), 580 tropin-releasing hormone (rats), 232 ear artery smooth muscle and endothe- Prefrontal cortex, dopamine metabolism, Radioligands, selectivity, beta adrenergic re- ceptors, quantitative analysis, 46 hum (rabbits), 100 stress-induced increase (rats), 693 short-term desensitization, neuroblas- Pressor mechanisms, adrenergic and non- Rafferty, M. F., see Contreras, P. C., 1101 Raghoebar, M., Peeters, P. A. M., van den toma cells (mice), 916 adrenergic, sympathectomy and opiate (rats), 1014 Berg, W. B. and van Ginneken, C. A. M.: Mechanisms of cell association of corticosterone and, hypothalamic-pi- Pressure, mean arterial, vasopressin and so- tuitary-adrenal axis (rats), 429 dium-dependent hypertension (rats), ch!oroquine to leucocytes, 302 Ramkumar, V., see El-Fakahany, E. E., 554 mu and delta, discriminative effects 492 (rats), 990, 997 Presynaptic mechanisms, sympathetic func- Ramsammy, L. S., Josepovitz, C., Ling, K.- Y., Lane, B. P. and Kaloyanides, G. putative kappa, activity (rats), 833 tion, cardiac (guinea pigs), 447 J.: Effects of diphenyl-phenylenedi- opioid delta and mu Procell, L. R, see Newball, H. H., 839 amine on gentamicin-induced lipid agonist activity (mice), 769 Prolactin peroxidation and toxicity in rat renal discriminative effects (rats), 990,997 desensitization, stimulatory effects of nic- cortex, 83 phencyclidine, acylating ligand for (rats), otine (rats), 486 Ranitidine, pharmacological comparison, 1101 tolerance to cannabinoid, suppression of H2 blockers (dogs), 587 regulation, flunitrazepam binding (rats), (rats), 1034 Rao, S., see Okamoto, M., 1004 749 Prostaglandin E Rauwolscine, a!pha-i,2 adrenoceptors, re- Schi!d plot limitations bone resorption and (mice), 778 sponse coupling, saphenous and fern- alpha adrenoceptors, vascular smooth verapamil and isoproterenol, airway oral veins (dogs), 131 muscle, 237 smooth muscle relaxation (dogs), 76 Receptor reserve thoracic aorta (rabbits), 802 verapamil effect on synthesis, hydrone- alpha-i and 2 adrenoceptors serotonin phrotic cortical interstitial cells (nab- effect of cooling, saphenous and femo- calcium channel antagonists and (rats), bits), 125 ral veins (dogs), 139 860 water handling and, kidney, 653 saphenous and femoral veins (dogs), phosphoinositide turnover by phorbol Prostaglandins, lung mediator release, re- 131 esters (rats), 480 duced oxygen tension, 8 calcium antagonists and, alpha-i adreno- thoracic aorta (rabbits), 802 Prostaglandin system, hydralazine effects ceptor-mediated pressor responses substance P, LRM55 glial cells, 389 and, regional blood flow, conscious (rats), 89 vasopressin, vascular, sodium-dependent state (dogs), 665 Receptors hypertension and (rats), 492 Prostate, effects on secretion, drugs that adenosine, vasodilator effects, sponta- Reflexes, micturition, substance P and K modify ion transport (dogs), 26 neous hypertension (rats), 954 activation, multiple tachykinin re- Protein alpha ceptors (rats), 259 1156 Index Vol. 238

Refractory period, ventricular, induced nisms ofgentamicin transport in kid- R., Jr.: Evaluation of alpha-i and a!- amiodarone biotransformation ney epitbe!ial cell line (LLC-PK1), pha-2 adrenoceptor-mediated vaso- (rats), 307 1071 constriction in the in situ, autoper- Regoli, D., see Maggi, C. A., 259 Salhab, A. S., see Shiverick, K. T., 1108 fused, pulmonary circulation of the Renquist, K. S., see Hubel, K. A., 167 Sallustio, B. C., see Jones, M. E., 288 anesthetized dog, 217 Repetitive firing, reduction of, carbamaze- Sallustio, B. C., see Meffm, P. J., 280 Sherlock, D. J., see Jaffe, B. M., 536 pine and, central neurons (mice), 727 Sampson, A. S., see Grandordy, B. M., 273 Shiverick, K. T., Swanson, C., Saihab, A. S. Respiration, interactions between verapa- Santicioli, P., see Maggi, C. A., 259,341 and James, M. 0.: Differential induc- mil and morphine, physiological pa- Sapbenous vein, nitroglycerin, blockade of tion of ethoxyresorufm-O-deethylase rameters (rats), 192 alpha-2 adrenoceptors (dog), 515 in tissues of the rat placenta, 1108 Respiratory burst, polymorphonuclear leu- Satoh, S., see Yorikane, R., 334 Shriver, D. A., see Katz, L. B., 587 kocytes, oxygen metabolite genera- Scatton, B., see Claustre, Y., 693 Shuman, R T., see Cohen, M. L., 769 tion, doxorubicin and doxorubicinol- SCH 23390 Simpson, P. J., Smith, C. B., Jr., Rosenthal, induced alterations, 19 dopamine or fenoldopam and, cyclic AMP G. and Lucchesi, B. R.: Reduction in Retina, a-aminobutyric acid enzyme mac- levels (rats), 547 the incidence of thrombosis by the tivation (rats), 508 methamphetamine-induced changes and, thromboxane synthetase inhibitor P. C., 1101 Rice, K. C., see Contreras, monoamine systems (rats), 932 CGS 13080 in a canine model of cor- Richardson-Carlson, R., see Kalivas, P. W., treatment, dopamine receptors and (rats), onary artery injury, 497 1126 846 Singer, R. M., see Ryan, M. J., 473 Rigel, D. F. and Katona, P. G.: Effects of Schenck, K., see Cohen, M. L., 860 SKF 38393, supersensitivity, apomorphine, antihistamines and local anesthetics Schild plots, limitations, alpha adrenocep- rotational behavior (mice), 242 on excess tachycardia in conscious tors, vascular smooth muscle, 237 Skolnick, P., see Barrett, J. E., 1009 dogs, 367 Schmid, P. G., Whiteis, C. A., Ode, R P. Smith, C. B., Jr., see Simpson, P. J., 497 Rinard, G. A., see Moore, D. H., 76 and Lund, D. D.: Presynaptic regu- Smith, D. M., see Cubells, J. F., 508 Rinehart, R. K., Barbaz, B., !yengar, S., lation of cardiac sympathetic func- Smith, E. R., Miller, T. B., Palermo, N. J. Ambrose, F., Steel, D. J., Neale, R. tion in guinea pigs, 447 F., Petrack, B., Bittiger, H., Wood, and Donovan, D. W.: Effects on ca- Schmitt, M., see Guentert, T. W., 295 nine prostatic secretion of some P. L. and Williams, M.: Benzodiaze- Schmoeker, P. F., see Cicero, T. J., 1063 drugs that modify ion transport, 26 pine interactions with central thy- Schnier, R. W., see Schwertschlag, U., 119 roid-releasing hormone binding sites: Smith, P. G., see Mills, E., 1014 Schwartz, D. D. and Eikenburg, D. C.: Car- Smith, T. W., see Wei, E. T., 783 Characterization and physiological diovascular responsiveness to sym- significance, 178 Snell, L. D. and Johnson, K. M.: Character- pathetic activation after chronic epi- ization of the inhibition of excitatory Rivy, J. P., see Claustre, Y., 693 nephrine administration, 148 Re 15-1788, antagonism, benzodiazepine- amino acid-induced neurotransmit- Scbwertschlag, U., Gerber, J. G., Barnes, J. ter release of the rat striatum by like drugs (monkeys), 522 S. and Nies, A. S.: A dual effect of phencycidine-like drugs, 938 RO5-4864, 3H-labeled, downregulation of, nonsteroidal anti-inflammatory Snyder, F. R., see Szikszay, M., 192 peripheral-type benzodiazepines, 855 drugs on renal water handling in hu- Snyder, S. H., see Largent, B. L., 739 Roques, B. P., see Bourgoin, S., 360 mans, 653 Sodium, transport, detergent effects, un- Rosen, M. R., see Spinel!i, W., 794 Schwertschlag, U., Schrier, R W. and Wil- nary bladder (toads), 415 Rosenbaum, J. S., Zera, P., Umans, V. A., son, P.: Beneficial effects of calcium Ginsburg, R. and Hoffman, B. B.: Sodium chloride channel blockers and CaImOdUlin Desensitization of aortic smooth cotransport, bumetanide and, renal thick binding drugs on in vitro renal cell limbs (mice), 407 muscle contraction in rats harboring anoxia, 119 pheochromocytoma, 396 transport, sodium-potassium-ATPase Scott, C. see Katz, L B., 587 Rosenthal, G., see Simpson, P. 497 (dogs), 327 J., Sedative hypnotics, long- and short-sleep Rossing, T. H. and Drazen, J. M.: Effects of Sodium-potassium-ATPase, transfer rate, with (mice), 1028 rnilrinone on contractile responses of sodium-chloride transfer and (dogs), Sejersted, 0. M., see Kiil, F., 327 guinea pig trachea, lung parenchyma 327 Serotonergic system, methamphetamine-in- and pulmonary artery, 874 Sodium valproate, chronic ethosuximide duced changes, dopamine receptor Roth, B. L., Nakaki, T., Chuang, D.-M. and sybtypes in (rats), 932 and, behavioral toxicity, epilepsy (ba- Costa, E.: 5-Hydroxytryptamine2 re- boons), 32 Serotonin ceptors coupled to phospholipase C Solaro, R. J., Bousquet, P. and Johnson, J. as a vasoconstrictor neurotransmitter, in rat aorta: Modulation of phos- D.: Stimulation of cardiac myofila- basilar artery (rabbits), 880 phoinositide turnover by phorbol es- forskolin-stimulated adenylate cyclase, ment force, ATPase activity and tro- tsr, 480 receptor-mediated inhibition, hippo- ponin C Ca binding by bepridil, 502 Rudolph, A. M., see Wang, L. H., 198 campal membranes (guinea pigs, Somogyl, G. T., see Vizi, E. S., 701 Ruffolo, R. R., Jr., see Shebuski, R. J., 217 rats), 248 Sonsalla, P. K., Gibb, J. W. and Hanson, G. Ryan, J. W., see Turnin, M., 14 R.: Roles of D1 and D2 receptor sub- Ryan, M. J., Bjork, F. A., Cohen, D. M., phosphoinositide turnover, phorbol ester and (rats), 480 types in mediating the methamphe- Coughenour, L. L., Major, T. C., Ma- receptor activation, calcium ion channel tamine-induced changes in mono- thias, N. P., Marts, T. E., Olszewski, amine systems, 932 B. J., Singer, R. M., Evans, D. B. and antagonists and (rats), 860 Sexual dimorphism, hepatic monooxygen- Spealman, R. D., see Wettstein, J. G., 522 Kaplan, H. R.: CI-926 (3-[4-[4-(3- Spector, S., see Johnson, M. D., 855 metbylphenyl)-1-piperazinyl]butylj- ase system, persistent defects, pbe- nytoin (rats), 68 Spilman, S. D., see Kraemer, F. B., 905 2,4-imidazolinedione): Antibyperten- Spinal cord sive profile and pharmacology, 473 Sham, see Perrone, M. H., 389 Shapiro, B. H., Lech, G. M. and Bardales, dynorphin A, administered intrathecally R. M.: Persistent defects in the he- (rats), 833 Sabouni, M. H., see Alkadhi, K. A., 547 patic monooxygenase system of adult Met-enkephalin-like release, kelatorphan Saito, A., Ishikawa, T., Masaki, T., Kimura, rats exposed, perinatally, to mater- (rats), 360 S. and Goto, K.: Pharmacological nally administered phenytoin, 68 Spinelli, W. and Rosen, M. R.: Frequency- analysis of autonomic innervation of Sharp, B. M. and Beyer, H. S.: Rapid desen- dependent actions of phenytoin in the right atria ofrats and guinea pigs: sitization ofthe acute stimulatory ef- adult and young canine Purkinje fi- Demonstration of nonadrenergic fects of nicotine on rat plasma adre- bers, 794 noncholinergic nerves, 713 nocorticotropin and prolactin, 486 Spry, L., Lakshmi, V. M., Zenser T. and Saito, H., Inui, K.-!. and Honi, R.: Mecha- Shebuski, R. J., Fujita, T. and Ruffolo, R. Davis, B.: Metabolism and excretion 1986 Index 1157

of nitrofurothiazole bladder carcino- mone and prolactin suppressive ef- N.: Uptake of N-[1(S)-carboxy-(4- gens, 457 fects of, chronic prepubertal treat- OH-3-125I-phenyl)ethylj-L-Ala-L- Starmer, C. F., see Moorman, J. R., 159 ment of female (rats), 1034 Pro, an inhibitor of angiotensin-con- Stassen, F., see Mann, W. A., 401 Tetrodotoxin venting enzyme by rabbit lungs in Steel, D. J., see Rinehart, R. K., 178 jejunal contractility, after chronic abla- situ, 14 Sterols, synthesis, ketoconazole effects, 905 tion, myenteric plexus (rats), 372 Tyrey, L., see Field, E., 1034 Stevens, C. W. and Yaksh, T. L.: Dynorphin neuropeptide Y, effect on ion transport, A and related peptides administered ileum (rabbits), 167 intrathecally in the rat: A search for Theophylline, prostatic secretion, drug- UDP-glucuronic acid, hepatic energy state, putative kappa opiate receptor activ- modified ion transport (dogs), 26 conjugation and (rats), 457 ity, 833 Thermoregulation, a!pha-i,2 adrenoceptors, UK 14,304 Stokes, G. S., see Marwood, J. F., 267 effect of cooling, saphenous and fern- a!pha-1,2 adrenoceptors Strauss, H. C., see Moorman, J. R., 159 oral veins (dogs), 139 effect of cooling, saphenous and femo- Streptozotocin, diabetes mellitus, bladder Thiazide diuretics, chloride absorption and, ral veins (dogs), 139 dysfunction in (rats), 773 distal colon (rabbits), 912 response coupling, saphenous and fern- Stress Thimerosal, acyl-coenzyme A:lysolecithin oral veins (dogs), 131 antidepressant drug injection and, amyg- acyltransferase inhibitors, endothe- Ulm, E. H., see Lin, J. H., 978 dala (rats), 758 hum-derived vascular relaxing factor Umans, V. A., see Rosenbaum, J. S., 396 cortical dopamine metabolism and (rats), (rabbits), 352 Urethan, central nervous system depres- 693 Thiorphan, kelatorphan, Met-enkephalin- sant, long- and short-sleep (mice), Striatal kainate lesions, benzodiazepine re- like release, spinal cord (rats), 360 1028 ceptors, regulation of (rats), 739 Thomasson, D. L., see Danon, A., 95, 125 Urinary bladder abnormalities of contractility, streptozo- Stumpf, W. E., see Duncan, G. E., 758 Thoolen, M. J. M. C., see Chits, A. T., 224 Stupecky, G. L., Murray, D. L. and Purdy, Thornburg, J. E., see Atchison, W. D., 618 tocin-induced diabetes (rats), 773 R. E.: Vasoconstrictor threshold syn- Threshold synergism, potentiation and, vas- cancer, nitrofurothiazole carcinogen me- ergism and potentiation in the rabbit oconstrictor, thoracic aorta (rabbits), tabolism (rats), 457 isolated thoracic aorta, 802 802 micturition reflex activation, substance P Submucous plexus, neuropeptide Y, effect Thrombin, artery contraction and, alpha ad- and K, multiple tachykinin receptors on ion transport, ileum (rabbits), 167 renoceptor agonists and (rabbits), (rats), 259 Substance K, substance P and, neurokinin 947 sodium transport, detergent effects (toads), 415 motor effect, duodenum (rats), 341 Thrombolysis, epithelial tissue plasminogen Substance P activator (rabbits), 254 transepitheial water flux, vasopressin an- receptors, see Receptors Thrombosis, coronary artery, thromboxane alog inhibition of (toads), 401 Urine, flow, a-hANP and (dogs), 707 substance K and synthetase inhibitor CGS 13080 ef- micturition reflex, multiple tachykinin fects (dogs), 497 receptors (rats), 259 Thromboxane A2, thrombosis and, coronary neurokinin motor effect, duodenum Valproic acid, chronic ethosuximide and, be- artery (dogs), 497 havioral toxicity, epilepsy (baboons), (rats), 341 Thromboxane synthetase, thrombosis and, Substantia nigra, depolarization block in- 32 coronary artery (dogs), 497 duction, midbrain dopamine neurons van den Berg, W. B., see Raghoebar, M., 302 Thurman, R. G., see Badr, M. Z., 1138 van Ginneken, C. A. M., see Raghoebar, M., (rats), 1092 Thurman, R. G., see Belinsky, S. A., 1132 302 Sulfation, pharmacokinetic studies, acet- Thyrotropin-releasing hormone, benzodi- aminophen disposition, maternal- Vanhoutte, P. M., see Flavahan, N. A., 131, azepine interactions, binding sites, 139 placental-fetal unit (sheep), 198 characterization (rats), 178 Sulpiride, methamphetamine-induced Vas deferens, CH-38083 effects (rats, mice), Tierney, M. A., see Grover, G. J., 868 changes and, monoamine systems 701 Timmermans, P. B. M. W. M., see Chiu, A. (rats), 932 Vasoconstriction T., 224 pulmonary circulation, alpha-1,2 adre- Superior cervical ganglion, DA1 receptor ac- Tine!, M., see Letteron, P., 685 tivation in, dopamine or denoldopam noceptors, evaluation (dogs), 217 Toda, N., Okamura, T. and Miyazaki, M.: sympathetic, renin secretion and, thyro- (rats), 547 Age-dependent changes in the re- Swanson, C., see Shiverick, K. T., 1108 tropin-releasing hormone (rats), 232 sponse of isolated beagle coronary ar- Sybertz, E., see Antonaccio, M. J., 378 Vasopressin, vascular effects of, chronic teries to transmural electrical stimu- Sympathectomy, adrenergic and nonadre- blockade, high sodium renal hyper- lation and catecholamines, 319 nergic pressor mechanisms (rats), tension during (rats), 492 Todd, E. L. and Abernethy, D. R.: Phar- 1014 Vasopressin agonists, inhibition of trans- macokinetics and dynamics of (±)- epithelial water flux, urinary bladder Sympathetic function, cardiac, presynaptic verapamil in lean and obese Zucker regulation (guinea pigs), 447 (toads), 401 rats, 642 Sympathetic nerves, beta adrenoceptor an- Ventral tegmenta! area, neuromedin N ac- Tohse, N., see Hattori, Y., 670 tagonists, antihypertensive effects tions, 1126 Trachea, smooth muscle, adrenoceptor-me- (rats), 372 Verapamil diated mechanical response (dogs), Sympathetic nervous system, vasopressin, effect of prostaglandin E synthesis, by- 679 sodium-dependent hypertension and dronephrotic cortical interstitial cells Transmitter release, neuronal uptake inhib- (rats), 492 (rabbits), 125 Szikszay, M., Snyder, F. R. and London, E. itor effects, drug interactions (nab- isoproterenol and prostaglandin E, air- D.: Interactions between verapamil bits), 437 way smooth muscle relaxation (dogs), and morphine on physiological pa- Transmural nerves, stimulation, serotonin 76 rameters in rats, 192 and, basilar artery (rabbits), 880 morphine interactions, calcium antago- Trichlormethiazide, chloride absorption fists, physiological parameters and, distal colon (rabbits), 912 (rats), 192 Tachycardia, excess, antihistamines and lo- Trifluoperazine, serotonin contraction and, pharmacokinetics and dynamics, obesity cal anesthetics (dogs), 367 uterus and jugular vein (rats), 860 and (rats), 642 Takenaga, T., see Yukimura, T., 707 Trqjonin, bepridil effects, cardiac myofila- Vermeulen, M., see Lambert, C., 307 Talmaciu, R. K., see Hoffmann, I. S., 437 ments (pigs), 502 Vince, R, see Dunham, E. W., 954 Tenoxicam, acceleration of elimination, Tsao, C. C., see Chelly, J. E., 665 Vizi, E. S., Harsing, L. G., Jr., Gas!, J., cholestyramine (dogs), 295 Turriui, M., Pitt, B. R., Ryan, J. W., Chung, Kapocsi, J., Bernath, S. and Somogyi, #{244}-9-Tetrahydrocannabinol, luteinizing hor- A. Y. K., Clark, M. B. and Gil!is, C. G. T.: CH-38083, a selective, potent 1158 Index Vol. 238

antagonist of alpha-2 adrenorecep- Weiss, J., Walker, S. T., Fallon, M. and Yaksh, T. L., see Stevens, C. W., 833 tors, 701 Goldfarb, S.: In vivo and in vitro ef- Yamamoto, K., see Yukimura, T., 707 fects ofWR-2721 in experimental by- Yamamura, H. I., see Gulya, K., 720 percalcemia in the rat, 969 Yamamura, H. I., see Hynes, M. R., 100 W6211, pH potentiation, drug pK, sodium Weissman, B. A., see Barrett, J. E., 1009 Yasumoto, T., see Kobayashi, M., 1077 channel blockade in ventricular myo- YC-170, vascular and cardiac effects, corn- cardium (guinea pigs), 159 Wettstein, J. G. and Spealman, R. D.: Be- havioral effects of zopiclone, CL 218, panison with Bay K 8644 (rabbits, Walewski, J. L., see Okamoto, M., 1004 guinea pig), 670 872 and diazepam in squirrel mon- Walker, M. J., see Carroll, M. E., 1 Yee, R, see Moorman, J. R., 159 keys: Antagonism by Ro 15-1788 and Walker, S. T., see Weiss, J., 969 Yohimbine Walter, J. B., see Moore, D. H., 76 CGS 8216, 522 aipha-2 adrenoceptors, question of exist- Wamsley, J. K., see Gulya, K., 720 Wetzel, G. T., see McDonough, P. M., 612 ence, tail arteries (rats), 267 Wang, L. H., Rudolph, A. M. and Benet, L. Whiteis, C. A., see Schmid, P. G., 447 sympathetic transmission, beta adre- Z.: Pharmacokinetic studies of the Williams, M., see Rinehart, R. K., 178 noceptors, heart (dogs), 334 disposition of acetaminophen in the Wilson, P., see Schwertschlag, U., 119 Yorikane, R., Kanda, A., Kimura, T. and sheep maternal-placental-fetal unit, Winkler, J. D. and Weiss, B.: Reversal of Satob, S.: Effects ofepinephnine, iso- 198 supersensitive apomorphine-induced proterenol and IPS-339 on sympa- Ward, S. J., LoPresti, D. and James, D. W.: rotational behavior in mice by con- thetic transmission to the dog heart: Activity of mu- and delta-selective tinuous exposure to apomorphine, Evidence against the facilitatory role opioid agonists in the guinea pig 242 of presynaptic beta adrenoceptors, ileum preparation: Differentiation Witkin, J. M., see Barrett, J. E., 1009 334 into peptide and nonpeptide classes Young, A. B., see Ciliax, B. J., 749 Wittenauer, L., see Cohen, M. L., 860 with -funaltrexamine, 625 Yukimura, T., Ito, K., Takenaga, T., Ya- Wong, B. K., see Corcoran, G. B., 54 Warltier, D. C., see Pelc, L. R., 113 mamoto, K., Kangawa, K. and Mat- Wood, P. L., see Iyengar, S., 429 Water, transepithelial flux, inhibition by suo, H.: Possible tubular site of ac- Wood, P. L., see Rinehart, 178 vasopressin agonists, urinary bladder R. K., tion in anesthetized dogs of a syn- (rats), 401 Woodwortb, J. R., Mayersohn, M. and thetic a-human atrial natriuretic Webner, J. M., see Manley, R. J., 1028 Owens, S. M.: Disposition kinetics of polypeptide, 707 Wei, E. T., Kiang, J. G., Buchan, P. and the monohydroxy metabolites of Smith, T. W.: Corticotropin-releas- phencyclidine in the dog, 900 Zenser, T. V., see Danon, A., 95, 125, 457 ing factor inhibits neurogenic plasma Woronick, C. L., see Maderazo, E. G., 453 Zera, P., see Rosenbaum, J. S., 396 extravasation in the rat paw, 783 Worth, T. S., see Dunwiddie, C. W., 564 Zopiclone, behavioral effects (monkeys), Weiss, B., see Winkler, J. D., 242 WR-2721, experimental hypercalcemia 522 Weiss, H. R., see Grover, G. J., 868 (rats), 969 Zuzack, J. S., see Li, J. H.-Y., 415 CoPnuGHT © 1986 BY WILLIAMS & WILKINS NOTICE TO CONTRIBUTORS

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