ABSTRACTS / RESÚMENES LUNES 13 DE DICIEMBRE / MONDAY, DECEMBER 13 INAUGURAL PLENARY LECTURES / CONFERENCIAS PLENARIAS INAUGURALES PL-01 THE CONCURRENT CHALLENGES OF EFFECTIVENESS RESEARCH AND INDIVIDUALIZED THERAPEUTIC STRATEGIES Gianni Tognoni South Institute for Pharmacological Research, Santa María Imbaro, Chiety, Italy. email:
[email protected] The proposal of focusing the attention on the two apparent extremes of care (on one side the public health relevance and transferability of the paradygm of EBM, on the other side one of the expected clinical yields of genomic-translational research) aims to underline and exemplify the strict complementarity of the two scenarios. Methodologically and operationally, both approaches do propose a very promising future for the development of pharmacological research, with closer links to the highly productive area of outcomes- oriented epidemiology and with the most advanced sector of basic sciences. It seems specifically important that the two areas could be developed in close interaction, possibly within the same department(s), to assure a productive interplay of competences in the collaboration with clinical care, as well as in the training of the new generations of pharmacologists, pharmacists, clinicians. PL-02 BASIC PERIPHERAL MOLECULAR COMPONENTS OF INFLAMMATORY PAIN H Ferreira School of Medicine of Ribeirão Preto. Department of Pharmacology, Campus USP, Ribeirão Preto, SP. Brazil. email:
[email protected] When non steroidal anti-inflammatory drugs mechanism of action was discovered, I proposed that their analgesic effect resulted from the prevention of the nociceptor sensitization by prostaglandins. Thus, pain in an inflammatory process results from an action of mechanical, thermal or chemical stimuli upon sensitized nociceptors (hiperalgesia, hypernociception-HPr).