Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ -A- 3-(N-ACETYLAMINO)-5-(N-DECYL-N- 1 mg 27.50 159549 METHYLAMINO)BENZYL ALCOHOL 5 mg 89.40 o A23187 0-5 C [103955-90-4] (ADMB) See: Antibiotic A23187 A Protein Kinase C activator. Ref.: Proc. Nat. Acad. Sci. USA, 83, 4214 AA-861 20 mg 72.70 (1986). 159061 Purity: 95% 100 mg 326.40 C20H34N2O2 MW 334.5 0oC Orally active, specific and potent inhibitor of 5-lipoxygenase. N-ACETYL-ASP-GLU 25 mg 45.00 153036 [3106-85-2] 100 mg 156.00 Ref.: 1. Yoshimoto, T., et.al., Biochim. o Biophys. Acta, 713, 470 (1982). 2. Ashida, -20-0 C An endogenous neuropeptide with high 250 mg 303.65 Y., et.al., Prostaglandins, 26, 955 (1983). 3. affinity for a brain "Glutamate" receptor. Ancill, R.J., et.al., J. Int. Med. Res., 18, 75 Ref: Zaczek, R., et al., Proc. Natl. Acad. (1990). Sci. (USA), 80, 1116 (1983). C21H26O3 MW 326.4 C11H16N2O8 MW 304.3 ABL PROTEIN TYROSINE KINASE 250 U 47.25 N-ACETYL-2-BENZYLTRYPTAMINE 195876 (v-abl) 1 KU 162.75 See: Luzindole -70oC Recombinant Expressed in E. coli ACETYL-DL-CARNITINE 250 mg 60.00 A truncated form of the v-abl protein 154690 [2504-11-2] 1 g 214.00 tyrosine kinase which contains the 0oC Hydrochloride minimum region needed for kinase activity Crystalline and fibroblast transformation. Suppresses C9H17NO4 • HCl MW 239.7 apoptosis and induces resistance to anti-cancer compounds. O-ACETYL-L-CARNITINE CHLORIDE 500 mg 11.45 Activity: 100 KU/ml 159062 [5080-50-2] 1 g 20.65 Unit Definition: one unit is the amount of 0-5oC (R-(-)-2-Acetyloxy-3-carboxy-N,N,N-trimethyl 5 g 97.45 enzyme which catalyzes the transfer of 1 -1-propanaminium chloride) pmol of phosphate to EAIYAAPFAKKK per Purity: >88% minute at 30°C, pH 7.5. A cholinergic agonist that stimulates Contains no detectable phosphatase and neuronal response to serotonin and protease and only trace amounts of RNase acetylcholine. and DNase. C9H18NO4Cl MW 239.7 MW 45 kDa ACETYLCHOLINE CHLORIDE, 50µCi 251.35 17032 14 250µCi 995.00 ACACETIN 10 mg 17.50 o [ACETYL-1- C] 193972 [480-44-4] 50 mg 85.00 0-5 C Sp. Act. 1-10 mCi/mmol 0-5oC (5,7-Dihydroxy-4′-methoxyflavone) 37-370 MBq/mmol Possesses antioxidant properties and an Ethanol inhibitor of rat liver glutathione Ref.: Nicholas, C., et al., J. Neurochem., S-transferase. 62, 1835-1839 (1994). Ref.: Zhang, K. and Das, N.P., Biochem. CH3CO2CH2CH2N(CH3)3Cl MW 181.6 Pharmacol., 47, 2063 (1994). ACETYL COENZYME A 1 mg 11.25 C16H12O5 MW 284.3 100490 [72-89-9] 5 mg 27.85 o ACETATE KINASE 250 U 50.00 0 C Trilithium Salt 10 mg 50.50 154678 [9027-42-3] 1 KU 189.80 Trihydrate 25 mg 111.15 o Purity: 92-95% 100 mg 359.00 0-5 C (ATP: Acetate phosphotransferase) • EC 2.7.2.1 C23H35Li3N7O17P3S 3H2O MW 881.1 From Escherichia coli N-ACETYL-L-CYSTEINE 25 g 22.00 Activity: 150-300 units/mg protein (Biuret). 100098 [616-91-1] 50 g 36.75 Unit Definition: One unit will 0-5oC Crystalline 100 g 66.25 phosphorylate 1.0 µmole of acetate to Purity: >96% 500 g 223.30 acetylphosphate per min at pH 7.6 at 25°C. A mucolytic agent for isolation of 1 kg 365.20 Suspension in 3.2 M (NH4)2SO4 solution, mycobacteria from sputum. pH approx. 6.0. C5H9NO3S MW 163.2 Contains less than 0.01% glutamic-oxalacetic transaminase, lactic N-ACETYL-L-CYSTEINE 5 g 12.75 dehydrogenase, myokinase and NADH 194603 [616-91-1] 10 g 20.00 oxidase. 0-5oC Cell Culture Reagent 25 g 28.10 Crystalline 50 g 45.00 ACETOHEXAMIDE 1 g 22.05 Purity: >96% 100 g 84.25 193572 [968-81-0] 5 g 88.20 A mucolytic agent for isolation of 500 g 260.20 RT (4-Acetyl-N-[(cyclohexylamino)- mycobacteria from sputum. carbonyl]benzenesulfonamide) C5H9NO3S MW 163.2 Hypoglycemic agent 14 L µ 1332.80 C15H20N2O4S MW 324.4 N-ACETYL- -CYSTEINE, [1- C] 50 Ci 16010 Sp. Act. 25-50 mCi/mmol o ACETOPROMAZINE 1 g 10.30 0-5 C 0.925-1.85 GBq/mmol 154683 [61-00-7] Ethanol solution. RT (2-Acetyl-10-[3-dimethyl-aminopropyl]phenot HSCH2CH(NHCOCH3)COOH hiazine) MW 163.2 Maleate Salt • 4-ACETYL-1,1-DIMETHYL- 5 mg 59.65 C19H22N2OS C4H4O4 MW 442.5 159683 PIPERAZINIUM IODIDE 10 mg 108.95 N-[2-(ACETOXY)ETHYL]-3- 1 mg 19.00 RT A nicotinic acid agonist 25 mg 217.85 159681 PYRIDINECARBOXAMIDE 5 mg 75.00 C8H17N2OI MW 284.1 o 0-5 C (Nicorandil Analog; SG-209) 10 mg 121.00 N-ACETYLDOPAMINE 10 mg 16.80 An analog of nicorandil that acts as a 25 mg 253.00 150229 [2494-12-4] 25 mg 33.10 nitrate-free vasodilator through activation of 0oC Crystalline 100 mg 90.10 potassium channels. Metabolite of dopamine 500 mg 247.20 C10H12N2O3 MW 207.2 C10H13NO3 MW 195.2

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ γ-ACETYLENIC GABA 1 mg 11.00 N-α-ACETYLGLYCYL-L-LYSINE 100 mg 8.80 193573 [57659-38-3] 5 mg 44.10 100182 METHYL ESTER 250 mg 17.80 RT (4-Amino-5-hexynoic acid) 25 mg 198.45 0oC [14752-92-2] 1 g 60.90 A GABA transaminase inhibitor. (AGLME) 5 g 280.55 Ref.: Schousboe, et al., Neurochem. Res., Acetate Salt 11, 1497 (1986). Crystalline C6H9NO2 MW 127.1 Substrate for measurement of urokinase activity. Ref.: Walton, P.L., Biochem. Biophys. Acta, N-ACETYL-S-FARNESYL-L-CYSTEINE 5 mg 71.35 132, 104 (1967). 159030 (AFC) 25 mg 306.00 C11H21N3O4 • C2H4O2 MW 319.4 o -20 C Purity: 98% 5 mg 59.65 Specific inhibitor of S-farnesyl- 1-ACETYL-4-METHYLPIPERAZINE cysteinemethyl transferase. Also prevents 159684 Hydrochloride 10 mg 108.95 carboxyl methylation of p21ras RT A nicotinic acid agonist 25 mg 217.85 platelet RAP C H N O • HCl MW 178.7 1 and the transduction γ subunit. 7 14 2 Ref.: 1. Volker, C., et.al., J. Biol. Chem., N-ACETYLNEURAMINIC ACID 10 mg 12.65 266, 21515 (1991). 2. Huzoor-Akabar, 194605 [131-48-6] 25 mg 25.35 et.al., ibid., 266, 4387 (1991). 3. 0-5oC (Sialic Acid; NANA; Type IV) 100 mg 66.15 Perez-Sala, D., et.al., Proc. Natl. Acad. Sci. Cell Culture Reagent 250 mg 145.55 USA, 88, 3043 (1991). From E. coli 500 mg 248.05 MW 367.5 White crystalline powder 1 g 439.90 Purity: ≥98% C11H19NO9 MW 309.3 N-ACETYL-S-FARNESYL-L- 50 µCi 605.15 3 5 mg 10.50 26020 CYSTEINE, [Cysteine-1- H] 250 µCi 1817.90 N-ACETYLNEURAMINIC ACID o 195854 [131-48-6] 25 mg 37.80 0-5 C Sp. Act. 10-20 Ci/mmol o 370-740 MBq/mmol 0-5 C (Sialic Acid; NANA) 100 mg 131.25 Ethanol From Bovine Milk Shipped in dry ice. C11H19NO9 MW 309.3 Please call for delivery information. N-ACETYLNEURAMINIC ACID 10 mg 12.60 MW 367.5 195855 [131-48-6] 50 mg 52.50 0-5oC (Sialic Acid; NANA) 250 mg 236.25 From Egg N-ACETYL-S-GERANYL-L-CYSTEINE 1 mg 20.20 Purity: ≥97% 195681 (AGC) 5 mg 92.40 C11H19NO9 MW 309.3 -20oC Purity: 98% A biologically inactive close structural N-ACETYL-PHE-NLE-ARG-PHE 0.5 mg 18.00 153039 1 mg 30.00 analog of AFC and AGGC. Used as a o AMIDE negative control. -20-0 C [83903-28-0] 5 mg 131.00 MW 299.4 A molluscan cardioexcitatory neuropeptide analog. C23H46N8O5 MW 622.8 N-ACETYL-S-GERANYLGERANYL-L- 5 mg 131.90 N-ACETYLPROCAINAMIDE 250 mg 11.95 159845 10 mg 229.30 193574 1 g 37.95 o CYSTEINE [34118-92-8] -20 C [139332-94-8] -20oC (4-(Acetylamino)-N-[2-(diethylamino)ethyl]ben (AGGC) zamide) Purity: 98% Hydrochloride Specifically inhibits methyl esterification of A metabolite of procainamide that blocks geranylgeranylated proteins. Also, it blocks potassium channels and exhibits some signal transduction in human neutrophils antiarrhythmic activity. that are receptor mediated. C15H23N3O2 • HCl MW 313.8 Ref.: 1. Phillips, M.R., et al., Science, 259, 977 (1993). N-ACETYL-D-SPHINGOSINE 1 mg 12.10 158923 [3102-57-6] 5 mg 40.20 2. Volker, C., et al., FEBS Lett., 295, 189 o (1991). -20 C (C2 Ceramide; N-Ethanoyl-D-sphingosine; MW 435.7 Acetyl ceramide) Purity: 98% Inhibitor of cell proliferation and inducer of β 1 mg 28.00 monocytic differentiation of HL-60 cells. N-ACETYL-D-GLUCOSAMINYL- - Stimulates cytosolic serine/threonine 158221 → 5 mg 125.95 o (1 4)-N-ACETYLMURAMYL-L- protein phosphatase in T9 cells at low -20 C ALANYL-D-ISOGLUTAMINE concentrations. (GMDP) Ref.: 1. Kim, M.-Y., et.al., J. Biol. Chem., Purity: 98% 266, 484 (1991). 2. Okazaki, T., et.al., ibid., Lyophilized 265, 15823 (1990). 3. Dobrowsky, R.T. and A novel synthetic analog of bacterial cell Hannun, Y.A., et.al., J. Biol. Chem., 267, wall glycopeptide which acts as a 5048 (1992). modulator of humoral and cellular immunity C20H39NO3 MW 341.5 reactions. Possesses immunoadjuvant and protective activity against bacterial and viral N-ACETYLTRYPTAMINE 5 mg 45.90 (including tumorigenic) infections. Differs 159685 Useful in determination of serotonin 10 mg 86.00 from well-known muramyl peptides in that it RT N-acetyl transferase 25 mg 172.00 contains GlcNAC attached to muramic acid C12H14N2O MW 202.2 via the β-(1→4) glycosidic bond. Soluble in H O, EtOH, MeOH, DMF, and ACIVICIN 10 mg 23.95 2 154259 [42228-92-2] 100 mg 164.95 physiological saline (1g/ml) o Ref.: 1. Campbell, M.J., et al., J. -20 C Purity: 99% Immunology, 145, 1029 (1990). Potent irreversible inhibitor of 2. Balitsky, K.P., et al., Int. J. gamma-glutamyl transpeptidase Immunopharmacol., 11, 429 (1989). (ID50=0.54mM). Potent anti-tumor agent. C5H7ClN2O3 MW 178.6

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ ACONITINE 25 mg 60.00 ADENOSINE-5′′′-O-(3- 1 mg 26.90 154710 [302-27-2] 100 mg 220.00 159551 THIOTRIPHOSPHATE) 5 mg 89.60 RT Purity: 95% -20oC [93839-89-5] Crystalline (ATP-γ-S) C34H47NO11 MW 645.7 Tetralithium Salt Purity: >80% ACTINOMYCIN D 1 mg 15.00 Ref.: Chrysogelos, S., et al., J. Biol. Chem., 104658 [50-76-0] 5 mg 65.00 258, 12624 (1983). 0-5oC Crystalline 10 mg 99.00 C10H12N5O12P3SLi4 MW 547.0 ∼ Purity: 98% 25 mg 205.00 ADENOSINE-5′′′-TRIPHOSPHATE 500 mg 15.40 Potent apoptosis inducer. 50 mg 315.00 100004 [42373-41-1] 1 g 25.00 Soluble in chloroform, acetone, methanol 100 mg 545.75 0oC Dipotassium Salt 5 g 118.80 and decomposed by strong acids, light. Purity: >96% C62H86N12O16 MW 1255.5 C10H14N5O13P3K2 MW 583.4 ACTINOMYCIN D 2 mg 40.20 ADENOSINE-5′′′-TRIPHOSPHATE 1 g 12.30 100008 [51963-61-2] 5 g 38.05 194525 [50-76-0] 5 mg 61.50 o 0-5oC Cell Culture Reagent 10 mg 115.75 0 C (ATP) 10 g 61.50 Crystalline 25 mg 240.35 Disodium Salt 25 g 135.30 Purity: ∼98% Crystalline 100 g 439.30 Inhibits nucleic acid synthesis and potently Purity: Approx. 99% induces apoptosis. C10H14N5Na2O13P3 MW 551.2 C H N O MW 1255.5 62 86 12 16 ADENOSINE-5′′′-TRIPHOSPHATE 1 g 20.60 194613 [51963-61-2] 5 g 52.60 ACTINOMYCIN D 1 mg 11.55 0oC (ATP) 10 g 94.80 196035 [50-76-0] 5 mg 48.85 Disodium Salt 0-5oC From Streptomyces parvulus 25 mg 179.00 Cell Culture Reagent Purity: ∼98% Crystalline Potent apoptosis inducer and nucleic acid Purity: ∼99% synthesis inhibitor. C10H14N5Na2O13P3 MW 551.2 Soluble in methanol. µ C62H86N12O16 MW 1255.5 ADENYLATE CYCLASE ACTIVATING 25 g 47.25 195879 PEPTIDE-27 100 µg 131.25 0-5oC [127317-03-7] ADENOSINE-3′′′,5′′′-cyclic- 25 mg 11.45 (PACAP-27) 105460 100 mg 28.45 o MONOPHOSPHATE His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Se 0 C [37839-81-9] 500 mg 89.45 r-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Ty ′ ′ (Adenosine-3 ,5 -Monophosphoric Acid) 1 g 166.40 r-Leu-Ala-Ala-Val-Leu-NH2 Sodium Salt Purity: ≥97% Crystalline MW 3147.6 Purity: Approx. 98% C10H11N5O6PNa MW 351.2 ADENYLATE CYCLASE ACTIVATING 100 µg 89.25 195880 PEPTIDE, Fragment 6-27 0-5oC ′′′ 100 mg 8.05 [136134-68-4] ADENOSINE-5 -DIPHOSPHATE Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gl 100056 [16178-48-6] 500 mg 28.95 o n-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Le 0 C (ADP-Na2) 1 g 47.30 u-NH2 From Equine Muscle 5 g 152.80 ≥ ≥ Purity: 97% Purity: 95% Inhibits PACAP-27 White to off-white powder MW 2638.1 Disodium Salt C10H13N5Na2O10P2 MW 471.2 ADENYLATE CYCLASE ACTIVATING 100 µg 189.00 195881 PEPTIDE-38 o ADENOSINE-5′′′-MONOPHOSPHATE 1 g 6.70 0-5 C [137061-48-4] 100080 [18422-05-4] 5 g 21.30 (PACAP-38) 0oC From Yeast 25 g 51.40 His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Se Free Acid 100 g 153.70 r-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Ty Crystalline r-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-G Purity: 99-100% ln-Arg-Val-Lys-Asn-Lys-NH2 C10H14N5O7P MW 347.2 More potent than VIP at stimulating adenylate cyclase. MW 4534.3 ADENOSINE-5′′′-MONOPHOSPHATE 1 g 7.10 150264 [4578-31-8] 5 g 18.20 ADRENALINE ELISA KIT 1 each 468.55 0oC (AMP) 25 g 83.40 193589 This adrenaline ELISA kit provides From Yeast 100 g 301.40 0-5oC materials for the quantitative measurement Disodium Salt of chemically derivatized adrenaline in Crystalline urine. The assay procedure follows the Purity: 99-100% basic principle of competitive ELISA C10H12N5Na2O7P MW 391.2 whereby there is competition between a biotinylated and non-biotinylated antigen for a fixed number of antibody binding sites. ADENOSINE-5′′′-O- 1 mg 28.45 The kit is a 12 x 8 well format. 159550 5 mg 94.30 o THIOMONOPHOSPHATE 0 C [93839-85-1] FOR RESEARCH USE ONLY! (AMP-S) Dilithium Salt AEBSF Acts as substrate and inhibitor for AMP-dependent enzyme systems. See: 4-(2-Aminoethyl)-benzenesulfonylfluoride Ref.: Murray, A.W. and Atkinson, M.R., Biochemistry, 7, 4023 (1968). AG-126 C H N O PSLi MW 375.1 10 12 5 6 2 See: Tyrphostin A10

To place an order: (800) 854-0530, fax (800) 334-6999 1148 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ AG-370 1-ALLYL-3,7-DIMETHYL-8- 5 mg 35.30 193577 PHENYLXANTHINE 10 mg 66.15 See: Tyrphostin B7 RT [149981-23-7] 25 mg 132.30 An A1 Adenosine receptor antagonist. AG-490 Ref.: Jacobson, et al., J. Med. Chem., See: Tyrphostin B42 38(18), 2639 (1993). C16H16N4O2 MW 296.3 AG-494 3-(4-ALLYLPIPERAZIN-1-YL)-2- 5 mg 98.60 See: Tyrphostin B48 159860 QUINOXALINECARBONITRILE 10 mg 166.25 RT Purity: 98% Selective antagonist of serotonin 5-HT3. AG-555 Ref.: Monge, A., et al., J. Med. Chem., 36, See: Tyrphostin B46 2745 (1993). MW 395.4 AG-879 1 mg 23.60 195715 Purity: 99% 5 mg 100.80 ALPHAXALONE 1 mg 16.55 RT A tyrphostin family member which inhibits 193579 [23930-19-0] 5 mg 55.10 the NGF receptor autophosphorylation RT (3α-Hydroxy-5α-pregnane-11,20-dione) 10 mg 99.20 selectively with no inhibition of EGF or A neurosteroid which acts upon the GABAA PDGF receptor phosphorylation. Inhibits receptor. NGF-induced neurite outgrowth in PC12 Ref.: Turner, et al., J. Pharmacol. Exp. cells. Ther., 248, 960 (1989). MW 316.5 C21H32O3 MW 332.5 AGMATINE SULFATE 250 mg 20.00 L-ALPRENOLOL 1 g 13.70 100274 [2482-00-0] 1 g 74.85 190092 [13707-88-5] 5 g 44.95 0oC (4-Guanidinobutane sulfate; Argamine) RT (L-1[2-Allylphenoxy]-3-isopropyl-aminopropan 25 g 149.65 Purity: 95-97% 2-ol) This is the enzymatic decarboxylation Hydrochloride product of arginine, which acts as an Crystalline imidazoline receptor agonist. Hydrate • • C5H14N4 • H2SO4 MW 228.3 C15H23NO2 HCl H2O MW 303.8 AGROCLAVINE 10 mg 11.00 ALRESTATIN 5 mg 45.90 193575 [548-42-5] 25 mg 22.05 159778 [51411-04-2] 10 mg 84.85 RT (8,9-Didehydro-6,8-dimethylergoline) 100 mg 79.40 RT (1,3-Dioxo-IH-benz[de]isoquinoline-2(3H)-ace 25 mg 169.70 An ergot alkaloid which acts as a dopamine tic acid) receptor agonist. Aldose reductase inhibitor. C16H18N2 MW 238.3 C14H9NO4 MW 255.2 ALAMETHICIN 5 mg 59.65 ALUMINUM CHLORIDE 100 g 8.85 159009 [27061-78-5] 10 mg 113.50 159552 [7784-13-6] 500 g 31.00 0-5oC (Antibiotic U-22324) 25 mg 271.15 RT (Aluminum trichloride) 1 kg 57.00 Mixture of alamethicin homologs. Antibiotic Hexahydrate which increases the permeability of Often used in aqueous solution with NaF to membranes. Also increases the induce a number of biological effects from 32 - incorporation of P into phosphatidylinositol generation of the (AlF4 ) moiety. 4-phosphate and sarcoplasmic reticulum AlCl3 • 6H2O MW 241.4 vesicles permeability. Ref.: 1. Brewer, D., et.al., Can. J. AMBENONIUM DICHLORIDE 5 mg 59.65 Microbiol., 33, 619 (1987). 2. Quist, E., 159687 [52022-31-8] 10 mg 108.95 et.al., Arch. Biochem. Biophys., 271, 21 RT A reversible, noncovalent inhibitor of acetyl 25 mg 217.85 (1989). cholinesterase. C28H42N4O2Cl4 MW 608.5 ALAPROCLATE 10 mg 16.55 193576 [60719-83-7] 25 mg 33.05 AMFONELIC ACID 5 mg 25.05 RT (DL-Alanine 100 mg 121.25 153650 [15180-02-6] 10 mg 45.05 2-(4-chlorophenyl)-1,1-dimethylethyl ester) 0-5oC (7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naph 25 mg 100.15 Hydrochloride thyridine-3-carboxylic acid) Powerful, selective serotonin uptake Dopamine releaser inhibitor. C18H16N2O3 MW 308.3 C H NO Cl • HCl MW 292.2 13 18 2 AMIDINOPHENYL BENZOATE 10 mg 16.55 ALLETHRIN 10 mg 35.80 194099 (APB; Try Inhibitor) 100 mg 55.10 159010 [584-79-2] 25 mg 85.40 0-5oC Hydrochloride 0-5oC (Allethrin I) 50 mg 166.55 A trypsin-like serine protease inhibitor. Mixture of 8 isomers Ref.: Markwardt, F., et al., Acta Biol. Meg. A Type I pyrethrin which demonstrates very Germ., 28, k19-k25 (1972). weak active "negative" control properties for calcineurin (protein phosphatase 2B) p-AMIDINOPHENYLMETHYL- 1 mg 18.00 194956 5 mg 62.40 inhibition by Type II pyrethrins. o SULFONYLFLUORIDE C19H26O3 MW 302.42 0-5 C [74938-88-8] (p-APMSF) ALLOPREGNANOLONE 1 mg 26.25 Hydrochloride 195886 [516-54-1] 5 mg 110.25 Purity: >75% RT (Allopregnan-3α-ol-20-one; A stable, non-toxic alternative to DFP or 3α-Hydroxy-5α-20-one) PMSF. Specifically and irreversibly inhibits Purity: ≥95% trypsin-like serine proteases, trypsin, and A neurosteroid with potent ligand properties thrombin. Demonstrates activity on factor against GABA Type A receptor complexes Xa, plasmin, C1r and C1s. Activity is 1000 in mammalian CNS potentiating the GABA fold greater than PMSF. receptor-mediated chloride uptake in Ref.: Cole, T.C., et al., Biochim. Biophys. synaptoneurosomes. Acta, 990, 254 (1989). C21H34O2 MW 318.5 MW 257.2

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ AMIDINOPHENYLPYRUVIC ACID 1 mg 12.65 N-(4-AMINOBUTYL)-2- 1 mg 55.25 194100 (APPA) 10 mg 76.05 159691 NAPHTHALENESULFONAMIDE 5 mg 218.60 0-5oC A polyvalent inhibitor for serine proteases 25 mg 165.35 0-5oC [89108-46-3] 10 mg 393.65 like trypsin, factor IIa, factor Xa, and plasma (W-12) kallikrein. It is a potent acrosin inhibitor, as Hydrochloride well as, an effective inhibitor of thrombin A calmodulin antagonist. and factor Xa clotting activity. It can Ref.: Hidaka, et al., Proc. Nat. Acad. Sci. distinguish between plasma kallikrein and USA, 78, 4354 (1981). glandular kallikrein, thrombin, and C14H18N2O2S • HCl MW 314.8 batroxobin (thrombin-like snake venom enzyme). γ-AMINOBUTYRIC ACID, [4-14C] 50 µCi 447.50 Ref.: Geratz, J.D., Arch. Biochem. 16011 Sp. Act. 50-60 mCi/mmol 250 µCi 1150.90 Biophys., 118, 90-6 (1967). 0-5oC 1.85 -2.22 GBq/mmol 0.01N HCl solution. AMILORIDE 50 mg 14.85 Please call for delivery information. 153537 [2016-88-8] 250 mg 36.15 H2NCH2(CH2)2COOH MW 137.0 RT (3,5-Diamino-N-(aminomethyl)-6- 1 g 72.25 chloropyrazinecarboxamide) γ-AMINO-n-BUTYRIC ACID 10 g 6.85 Hydrochloride 100278 [56-12-2] 25 g 9.85 A sodium ion channel inhibitor RT (GABA; 4-Aminobutanoic acid) 100 g 23.60 C6H8ClN7O • HCl MW 266.1 Crystalline 500 g 93.50 Purity: Approx. 99% 1 kg 152.90 7-AMINOACTINOMYCIN D 1 mg 65.70 C4H9NO2 MW 103.1 195856 [7240-37-1] o γ µ 0-5 C (7-AAD; 7-Amino-AMD; 7-Actinomycin C1; -AMINOBUTYRIC ACID 10 g 86.20 693281 7-Aminodactinomycin) o MONOCLONAL ANTIBODY Purity: ≥95% 0-5 C Anti-GABA DNA intercalator and growth inhibitor Clone: AD5A9 against certain forms of leukemia and Isotype: mouse IgG1 presented affinity sarcomas. purified MW 1270.4 Conc/Titer: 100 µg/ml Applications: Immunohistochemistry 3-AMINOBENZAMIDE 100 mg 25.60 The original immunogen was GABA 159028 [3544-24-9] 250 mg 49.70 coupled to BSA. The antibody is highly RT (PARP Inhibitor) 1 g 133.95 specific to GABA, a non-protein amino acid Purity: 97% 5 g 530.00 neurotransmitter, and does not react with Endogenous poly-ADP-ribosyltransferase other amino acids. inhibitor. Ref.: Kozak, K.R. and Ross, I.A., Biochem. 5-AMINO-3-(3-CHLORO-2-METHYLPHENYL)-1,2,3,4-OXA- Biophys. Res. Commun., 179, 1225 (1991). TRIAZOLIUM C7H8N2O MW 136.2 See: GEA 5024 1-AMINOBENZOTRIAZOLE 20 mg 30.00 159861 [1614-12-6] 50 mg 70.00 3-AMINO-2-(4-CHLOROPHENYL)-2- 1 mg 20.00 RT Purity: 99% 100 mg 130.60 159693 HYDROXYPROPANESULFONIC ACID 5 mg 75.00 Suicide inhibitor of cytochrome P-450 and RT [117354-64-0] 10 mg 142.80 chloroperoxidase. Oxidative drug (2-Hydroxysaclofen) metabolism inhibitor in in vivo studies. Purity: 98% min. Ref.: 1. Matthews, J.M., et al., J. Selective antagonist at GABAB receptors. Pharmacol. Exp. Ther., 235, 186 (1985). Also see Phaclofen 2. Mico, B.A., et al., Biochem. Toxicol., 37, C9H12NO4SCl MW 265.7 2515 (1988). 3. Mugford, C.A., et al., Fundam. Appl. 3-AMINO-2-(4-CHLOROPHENYL)- 1 mg 28.65 Toxicol., 19, 43 (1992). 159692 PROPANE SULFONIC ACID 5 mg 114.65 C6H6N4 MW 134.1 RT [125464-42-8] 10 mg 217.85 (Saclofen) p-AMINOBENZOYL-GLY-PRO-D-LEU- 1 mg 20.00 Selective antagonist at GABAB receptors. C H NO SCl MW 249.7 195664 D-ALA-HYDROXAMIC ACID 5 mg 84.20 9 12 3 0-5oC [124168-73-6] Purity: 97% 3-AMINO-2-(4CHLOROPHENYL)PROPANE-PHOS- Broad spectrum protease inhibitor against PHONIC ACID human matrix metalloproteinase, collagenase, gelatinase and stromelysin. See: Phaclofen C23H34N6O6 MW 490.6 p-AMINOCLONIDINE 1 mg 23.95 153649 [73217-88-6] 5 mg 78.35 AMINOBENZTROPINE 5 mg 16.55 o 193738 (3-(2′-Aminobenzhydryloxy)tropane) 25 mg 55.10 0-5 C Hydrochloride 10 mg 129.90 α2-Adrenergic receptor agonist RT Muscarinic ligand with very high affinity. 100 mg 198.45 • Useful for solubilizing muscarinic receptors. C9H10Cl2N4 HCl MW 281.5 Ref.: Haga, et al., J. Biol. Chem., 258, 13575 (1983). cis-4-AMINOCROTONIC ACID 1 mg 28.65 C H N O MW 322.4 159694 [55199-25-2] 5 mg 114.65 21 26 2 -20oC (Z-4-Amino-2-butenoic acid) An analog of GABA. Used as a probe for N-(4-AMINOBUTYL)-5-CHLORO-2- 1 mg 55.20 bicuculline-insensitive GABA receptors. 159690 5 mg 218.50 NAPHTHALENESULFONAMIDE C4H7NO2 MW 101.1 0-5oC [88519-57-7] 10 mg 393.65 (W-13) trans-4-AMINOCROTONIC ACID 1 mg 17.20 Hydrochloride 159695 [38090-53-8] 5 mg 63.05 A calmodulin antagonist RT (E-4-Amino-2-butenoic acid) 25 mg 252.25 Ref.: Stroble and Peterson, J. Pharm. Exp. Potent bicuculline-sensitive GABA agonist Ther., 263, 186 (1992). and GABA uptake inhibitor. • C14H17N2O2SCl HCl MW 349.3 C4H7NO2 MW 101.1

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 1-AMINOCYCLOBUTANE- 5 mg 29.80 (±)-2-AMINO-6,7-DIHYDROXY-1,2,3,4- 10 mg 51.05 159696 CARBOXYLIC ACID 10 mg 53.00 153647 TETRAHYDRONAPHTHALENE 15 mg 72.95 RT [22264-50-2] 50 mg 212.10 0-5oC [73304-33-3] 25 mg 115.70 A specific NMDA receptor antagonist which (6,7-ADTN HBr) acts at the glycine site. Hydrobromide Ref.: Hood, et al., Eur. J. Pharmacol., 161, Dopamine agonist 281 (1989). C10H13NO2 • HBr MW 260.2 C5H9NO2 MW 115.1 4-(2-AMINOETHYL)BENZENE- 10 mg 11.00 50 mg 31.95 1 mg 15.50 193503 SULFONYL FLUORIDE 1-AMINOCYCLOBUTANE-cis-1,3- RT 100 mg 54.50 158856 5 mg 70.00 [30827-99-7] DICARBOXYLIC ACID 500 mg 207.05 RT 10 mg 120.00 Hydrochloride [117488-23-0] 1 g 300.00 25 mg 286.00 (AEBSF) (trans-1-Aminocyclobutane-1,3-dicarboxylic Purity: 97% (HPLC) acid, IUPAC name) A covalent binding serine protease inhibitor. Monohydrate ≥ AEBSF belongs to the family of irreversible Purity: 99% sulfonyl fluoride inhibitors that block trypsin The most potent and highly selective and chymotrypsin-type enzymes. Similar in synthetic NMDA agonist known. structure to the commonly used inhibitor Ref.: 1. Lanthorn, T.H., et.al., Eur. J. PMSF, AEBSF offers better solubility in Pharmacol., 182, 397 (1990). 2. Allen, R.D., water, lower toxicity, greater stability and et.al., J. Med. Chem., 33, 2905 (1990). higher inhibitory activity. Note: Some confusion exists concerning • the name of this item, due to contradictions C6H10FNO2S HCl MW 239.7 in the literature. This isomer has the two N-(2-AMINOETHYL)-4- 10 mg 13.75 carboxyl groups on the same side of the 159707 CHLOROBENZAMIDE 50 mg 40.10 cyclobutyl ring. RT 100 mg 68.75 • [94319-79-6] C6H9NO4 H20 MW 177.16 (Ro 16-6491) Hydrochloride (±)-1-AMINOCYCLOPENTANE-cis-1,2- 1 mg 21.20 A monoamine oxidase-β inhibitor. 159702 DICARBOXYLIC ACID 5 mg 84.85 C9H11N2OCl • HCl MW 235.1 RT A structural analog of (±)-1-Amino- 10 mg 158.20 cyclopentane-cis-1,3-dicarboxylic acid. N-(2-AMINOETHYL)-5-CHLORO- 10 mg 57.85 158858 25 mg 137.60 C7H11NO4 MW 173.2 NAPHTHALENE-1-SULFONAMIDE 0oC (A-3) 50 mg 263.70 Purity: 98% (±)-1-AMINOCYCLOPENTANE-cis-1,3- 1 mg 20.00 Inhibitor of PKA, PKG, MLCK, and protein 159704 DICARBOXYLIC ACID 5 mg 95.00 kinase C. RT [39026-63-6] 10 mg 183.60 Ref.: Inagaki, M., et.al., Mol. Pharmacol., Potent NMDA agonist. A 1:1 mixture of 29, 577 (1986). (1R,3R) & (1S,3S)-enantiomers. MW 321.2 C7H11NO4 MW 173.2 N-(2-AMINOETHYL)-3- 1 mg 13.75 159709 IODOBENZAMIDE 5 mg 52.75 (±)-1-AMINOCYCLOPENTANE-trans- 1 mg 33.25 o 159705 5 mg 80.00 0-5 C Hydrochloride 10 mg 97.45 1,3-DICARBOXYLIC ACID β 25 mg 215.00 RT [39026-64-7] 10 mg 153.00 Reported to be a stronger MAO- inhibitor Glutamate receptor agonist. A 1:1 mixture than N-(2-Aminoethyl)-4-chlorobenzamide. of (1R,3R) & (1S,3S)-enantiomers. Ref.: Annan and Silverman, J. Med. Chem., 36, 3968 (1993). C7H11NO4 MW 173.2 C9H11N2OI • HCl MW 326.6 (±)-1-AMINOCYCLOPENTANE-trans- 250µCi 1090.25 N-(2-AMINOETHYL)-5- 10 mg 68.75 26021 3 1mCi 2060.45 158859 25 mg 157.65 1,3-DICARBOXYLIC ACID, [4,5- H] o ISOQUINOLINESULFONAMIDE 0-5oC Sp.Act. 200-300 mCi/mmol 0 C [84468-17-7] 50 mg 286.65 7.4-11.1 GBq/mmol (H-9) Ethanol: water solution (2.8) Dihydrochloride HPLC Analyzed for Purity. Purity: 99% Please call for delivery information. Excellent for chromatographic purification of HOCH2(CHOH)3COCH2OH MW 180.2 protein kinases. Protein kinase inhibitor. Ref.: 1. Hidaka, H., et.al., Biochemistry, 23, 5036 (1984). 2. Inagaki, M., et.al., J. Biol. 5-AMINO-3-(3,4-DICHLOROPHENYL)-1,2,3,4-OXATRIA- Chem., 260, 2922 (1985). 3. Wolf, M., et.al., ZOLIUM ibid., 260, 15718 (1985). • See: GEA 3162 C11H13N3O2S 2HCl MW 324.3 2-AMINOETHYLPHOSPHONIC ACID 100 mg 20.00 3-AMINO-2,4-DICYANO-5-(4-HYDROXYPHENYL)PENTA- 159710 [2041-14-7] 250 mg 33.45 RT C2H8NO3P MW 125.1 2,4-DIENONITRILE See: Tyrphostin A48 2-AMINOETHYLSULFINIC ACID See: Hypotaurine (±)-3-AMINO-2,3-DIHYDROBENZOIC 10 mg 34.95 158857 ACID 25 mg 80.00 (±)-p-AMINOGLUTETHIMIDE 25 mg 14.45 0oC [59556-17-1] 50 mg 147.00 153645 [125-84-8] 50 mg 23.95 (Gabaculine HCl) RT Inhibitor of cytochrome P-450-dependent 100 mg 43.35 Hydrochloride hydroxylation reactions. An irreversible potent inhibitor of C13H16N2O2 MW 232.3 γ -aminobutyric acid transaminase. 15 mg 25.35 Ref.: 1. Metcalf, B.W., Biochem. R(+)-p-AMINOGLUTETHIMIDE Pharmacol., 28, 1705 (1979). 153643 TARTRATE 25 mg 39.80 2. Loscher, W., Naunyn-Schmiedeberg’s RT [57344-88-4] 50 mg 72.25 Arch. Pharmacol., 315, 119 (1980). An active enantiomer of p-aminoglutethimide. C7H9NO2 • HCl MW 175.6 C13H16N2O2 • C4H6O6 MW 382.4

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ S(-)-p-AMINOGLUTETHIMIDE 15 mg 25.35 7-AMINOKETANSERIN 25 mg 321.05 153644 TARTRATE 25 mg 39.80 158860 (R 63234) 50 mg 584.75 RT (S(-)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidine 50 mg 72.25 RT Purity: 99% dione tartrate) Affinity ligand for 5-HT and histamine An enantiomer of p-aminoglutethimide receptors. which is less active. Ref.: 1. Wouters, W., et.al., Biochem. C13H16N2O2 • C4H6O6 MW 382.4 Pharmacol., 35, 3199 (1986). 2. Wouters, W., et.al., FEBS, 182, 291 (1985). 3. Wouters, W., et.al., J. Biol. Chem., 260, AMINOGUANIDINE BICARBONATE 100 g 9.25 8423 (1985). 150349 [2582-30-1] 500 g 24.00 MW 410.4 RT (Guanylhydrazine bicarbonate) Crystalline AMINOMALONIC ACID 1 mg 13.75 CH6N4 • H2CO3 MW 136.1 159713 [1068-84-4] 5 mg 38.95 o -20 C C3H5NO4 MW 119.1 25 mg 155.90 25 mg 25.40 N-(6-AMINOHEXYL)-5-CHLORO-1- ′′′ ′′′ 154186 NAPHTHALENESULFONAMIDE 100 mg 82.25 2 -AMINO-3 -METHOXYFLAVONE 1 mg 26.25 o 195935 (PD 98059) 5 mg 99.75 0-5 C [61714-27-0] 250 mg 167.00 o (W7) -20 C Purity: >95% Hydrochloride MAP kinase activation inhibitor. Inhibits cell Purity: ≥98% growth and reverses the phenotype of W7 is a vascular relaxing agent which ras-transformed BalB 3T3 fibroblasts. affects vascular smooth muscle C16H13NO3 MW 267.3 actomyosin. W7 is also a calmodulin α β antagonist that binds to calmodulin and -AMINO- -METHYLAMINO- 10 mg 27.00 2+ 154187 50 mg 94.70 inhibits Ca calmodulin-regulated enzyme o PROPIONIC ACID activities. 0-5 C Hydrochloride 100 mg 159.80 ° C16H21ClN2O2S • HCl MW 377.3 mp 165-167 C Purity ≥98% An amino acid isolated from the seeds of N-(6-AMINOHEXYL)-5-CHLORO-2- 1 mg 55.25 Cycas Circinalis that is neurotoxic to higher 154743 5 mg 148.50 animals. o NAPHTHALENESULFONAMIDE 0-5 C [69762-85-2] 10 mg 267.80 C4H11O2N2 • HCl MW 155.5 Hydrochloride A calmodulin antagonist 4-AMINO-1,8-NAPHTHALIMIDE 5 mg 21.00 Ref.: Hidaka, H., et al., Proc. Nat. Acad. 196027 [1742-95-6] 25 mg 78.75 Sci. USA, 78, 4354 (1981). RT (PARP Inhibitor) C16H21ClN2O2S • HCl MW 377.3 Purity: ≥96% Reduces ischemia-reperfusion injury in the heart and skeletal muscles. N-(6-AMINOHEXYL)-1- 1 mg 45.95 MW 212.2 154744 NAPHTHALENESULFONAMIDE 5 mg 180.80 o 0-5 C [61714-25-8] 1,2-bis(o-AMINOPHENOXY)ETHANE- 25 mg 136.50 (W5) 195709 ′′′ ′′′ o N,N,N ,N -TETRAACETIC ACID Hydrochloride -20 C TETRAACETOXYMETHYL ESTER Reported to be a calmodulin antagonist. [126150-97-8] Ref.: Hidaka, H., et al., Proc Nat. Acad. (BAPTA-AM) Sci. USA, 78, 4354 (1981). • Purity: >90% C16H22N2O2S HCl MW 342.9 A cell permeable derivative of BAPTA widely used as an intracellular calcium N-(6-AMINOHEXYL)-2- 1 mg 34.90 sponge. 154745 NAPHTHALENESULFONAMIDE 5 mg 138.70 C34H40N2O18 MW 764.7 0-5oC [35517-14-7] Hydrochloride D-(-)-2-AMINO-4-PHOSPHONO- 1 mg 30.00 Ref.: Hidaka, H., et al., 158861 BUTYRIC ACID 5 mg 123.90 Proc Nat. Acad. Sci. USA, 78, 4354 (1981). RT [78739-01-2] C16H22N2O2S • HCl MW 342.9 (D-(-)-2-Amino-4-phosphono- butanoic acid; D-AP4) Purity: 98% 4-AMINO-5-HEXYNOIC ACID NMDA antagonist. γ Ref.: Davies, J. and Watkins, J.C., Brain See: -Acetylenic GABA Res., 235, 378 (1982). C4H10NO5P MW 183.1 ± α 1 mg 33.85 ( )- -AMINO-3-HYDROXY-5-METHYL- L-(+)-2-AMINO-4-PHOSPHONO- 1 mg 49.30 159712 ISOXAZOLE-4-PROPIONIC ACID 5 mg 137.60 158862 5 mg 114.80 RT 10 mg 258.00 BUTYRIC ACID (AMPA) RT [23052-81-5] Dihydrate (L-(+)-2-Amino-4-phosphono- Selective quisqualate-like agonist. • butanoic acid; L-AP4) C7H10N2O4 H2O MW 220.2 Purity: 99% NMDA agonist and synaptic depressant. (±)-α-AMINO-3-HYDROXY-5-METHYL- 1 mg 43.25 Ref.: 1. Davies, J. and Watkins, J.C., Brain 154747 ISOXAZOLE-4-PROPIONIC ACID 5 mg 189.20 Res., 235, 378 (1982). 2. Koerner, J.F. and 0-5oC [118896-96-1] 10 mg 344.00 Cotman, C.W., Brain Res., 216, 192 (1981). (AMPA) C4H10NO5P MW 183.1 Hydrobromide ± Potent quisqualate-like agonist ( )-2-AMINO-4-PHOSPHONO- 25 mg 26.10 Ref.: 1. Krogsgaard-Larsen, P., et al., 153641 BUTYRIC ACID 50 mg 46.30 Nature (London), 284, 64 (1980). 2. RT [20263-07-4] 100 mg 86.75 Honore, T., et al., J. Neurochem., 38, 173 (DL-2-Amino-4-phosphono- (1982). butanoic acid; AP-4) Purity: 99% C7H10N2O4 • HBr MW 267.1 C4H10NO5P MW 183.1

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ L-(+)-AMINO-4-PHOSPHONO- 250 µCi 1091.35 2-AMINOPURINE 25 mg 10.10 26023 BUTYRIC ACID, [2,3-3H] 1 mCi 2060.45 159862 [452-06-2] 100 mg 52.95 0-5oC (AP 4) RT (2-AP) 250 mg 109.00 Sp. Act. 40-60 Ci/mmol Purity: 98% 500 mg 204.00 1.48-2.22 TBq/mmol Selective protein kinase inhibitor active on Ethanol:water (1:1) p58 PITSLREβ1 (a p34cdc2-related protein Shipped in dry ice. kinase) which may be used to override Please call for delivery information. multiple cell cycle checkpoints and MW 183.1 drug-induced cell cycle blocks. Ref.: 1. Andreassen, P.R. and Margolis, R.L., Proc. Natl. Acad. Sci. USA, 89, 2272 (1992). (±)-2-AMINO-7-PHOSPHONO- 2 mg 31.80 2. Xiang, J., et al., Biochem. Biophys. Res. 153640 5 mg 62.20 o HEPTANOIC ACID Commun., 199, 1167 (1994). 0-5 C [85797-13-3] 10 mg 115.70 C5H5N5 MW 135.1 (AP-7) NMDA antagonist C7H16NO5P MW 225.2 4-AMINOPYRIDINE 5 g 5.00 150366 [504-24-5] 10 g 7.60 RT Purity: ∼98% 25 g 15.25 Pink to red crystals 100 g 52.45 D 1 mg 49.30 -(-)-2-AMINO-5-PHOSPHONO- C5H6N2 MW 94.1 158863 PENTANOIC ACID RT [79055-68-8] (D-(-)-2-Amino-5-phosphono- 9-AMINO-1,2,3,4- 1 g 16.15 valeric acid; D-AP5) 154198 TETRAHYDROACRIDINE 5 g 72.00 Purity: 99% 0-5oC [1684-40-8] 10 g 137.80 Active form of AP5, and a competitive (Tacrine HCl; THA) NMDA antagonist. Hydrochloride Ref.: 1. Watkins, J.C., et.al., Ann. Rev. Hydrate Pharmacol. Toxicol., 21, 165 (1981). 2. Purity: ≥98% Hansen, J.J. and Krogsgaard-Larsen, P., A potent centrally acting anticholinesterase Med. Res. Rev., 10, 55 (1990). for therapy of memory deficits in patients C5H12NO5P MW 197.1 with Alzheimers’s disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a L-(+)-2-AMINO-5-PHOSPHONO- 1 mg 36.40 158864 5 mg 131.90 prolongation of the action potential of the PENTANOIC ACID presynaptic cholinergic neurons. RT [79055-67-7] C13H14N2 • HCl • H2O MW 252.7 (L-(+)-2-Amino-5-phosphono- valeric acid; L-AP5) Purity: 99% 5-AMINOVALERIC ACID 1 g 7.90 Less active form than AP5. 150370 [627-95-2] 5 g 27.95 Ref.: 1. Watkins, J.C., et.al., Ann. Rev. RT Crystalline 25 g 84.65 Pharmacol. Toxicol., 21, 165 (1981). 2. Hydrochloride Hansen, J.J. and Krogsgaard-Larsen, P., A weak GABA receptor antagonist. Med. Res. Rev., 10, 55 (1990). B C5H11NO2 • HCl MW 153.6 C5H12NO5P MW 197.1

AMIODARONE 250 mg 21.50 (±)-2-AMINO-5-PHOSPHONO- 2 mg 23.15 153535 [1951-25-3] 1 g 70.85 153639 PENTANOIC ACID 5 mg 30.00 RT (2-Butyl-3-benzofuranyl)-[4-[2-(diethylamino)e RT 10 mg 51.00 thoxy]-3,5-diiodo-phenyl]-methanone [76326-31-3] hydrochloride) (AP-5; DL-2-Amino-5-phosphono- Hydrochloride valeric acid) • Potent NMDA antagonist C25H29I2NO3 HCl MW 681.8 C5H12NO5P MW 197.04 AMOXAPINE 100 mg 15.45 193612 [14028-44-5] 500 mg 63.95 D-(-)-AMINO-5-PHOSPHONO- 250 µCi 842.85 RT (2-Chloro-11-(1-piperazinyl)- 26054 PENTANOIC ACID, [4,5-3H] 1 mCi 1758.50 dibenz[b,f][1,4]oxazepine) 0-5oC (AP 5) Inhibitor of norepinephrine uptake in Sp. Act. 20-40 Ci/mmol neurons. 0.74-1.48 TBq/mmol C17H16N3OCl MW 313.8 Ethanol:water (1:1) Shipped in dry ice. Please call for delivery information. AMPA MW 197.13 See: (±)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

N-(3-AMINOPROPYL)- 1 mg 13.75 2-(p-AMYLCINNAMOYL)AMINO-4- 20 mg 91.70 159720 CYCLOHEXANAMINE 5 mg 42.40 159014 CHLOROBENZOIC ACID 50 mg 212.10 RT [3312-60-5] 25 mg 169.70 RT (ONO-RS-082) 100 mg 401.30 Dihydrochloride Purity: 98% Inhibitor of spermine and spermidine Blocks PLA2 in human platelets which synthases. inhibits epinephrine-stimulated Ref.: Chu, et al., Eur. J. Pharm., 256, 155 thromboxane production. (1994). Ref.: Banga, H.S., et.al., Proc. Natl. Acad. C9H20N2 • 2HCl MW 229.2 Sci. USA, 83, 9197 (1986). MW 371.9

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ N-(p-AMYLCINNAMOYL)- 50 mg 74.55 ANNEXIN I 50 µg 396.90 159020 ANTHRANILIC ACID 100 mg 131.90 691542 MONOCLONAL ANTIBODY RT [110683-10-8] 250 mg 298.10 -20oC (anti-Lipocortin I; anti-Calpactin II; (ACA) anti-Chromobindin 9; anti-p35) Purity: 99% Anti-Human A close structural analog to ono-rs-082 Clone: II-29 which is a less potent PLA2 inhibitor. Also Isotype: mouse IgG1 demonstrates some leukotriene Conc/Titer: 1:5,000 antagonistic activity. Applications: Immunoblotting; ELISA; Ref.: 1. Banga, H.S., et.al., Proc. Natl. Immunohistochemistry Acad. Sci. USA, 83, 9197 (1986). 2. Nakai, This antibody reacts strongly with annexin I H., et.al., J. Med. Chem., 21, 78 (1986). from human or bovine tissue and does not MW 337.4 cross-react with other annexins or other proteins in a total lysate of human (+)-ANATOXIN A 250 µg 133.00 fibroblasts as determined by Western Blot. 159873 [64314-16-5] It is packaged at a concentration of 1 mg/ml -20oC (2-Acetyl-9-azabicyclo- in 50% glycerol, 5 mM TRIS, pH 8.2, 25 [4.2.1]non-2-ene HCl) mM NaCl, and 1.5 mM sodium azide. From Anabaena flos-aquae Purity: ≥95% Hydrochloride The hybridoma was elicited to annexin I Purity: 99% purified from bovine lung. Potent neuronal nicotinic acetylcholine Ref.: 1. Creutz, C.E., et al., J. Biol. Chem., receptor agonist. At high concentrations, it 262, 1860 (1987). desensitizes the receptor, blocks 2. Zokas, L. and Glenney, J.R., J. Cell. neuromuscular transmission, and blocks Biol., 105, 2111 (1987). the AChR ion channel. Ref.: 1. Thomas, P., et al., J. Neurochem., 60, 2308 (1993). 2. Swanson, K.L., et al., Mol. Pharmacol., 29, 250 (1986). 3. Kofuji, P., et al., J. Pharmacol. Exp. Ther., ANNEXIN II 50 µg 391.40 252, 517 (1990). 691552 MONOCLONAL ANTIBODY o C10H15NO • HCl MW 201.5 -20 C (Anti-Lipocortin II; anti-Calpactin I; anti-p36; anti-Chromobindin 8; anti-Protein I; 6-ANILINO-5,8-QUINOLINEDIONE 10 mg 93.50 anti-PAP IV) 158866 [91300-60-6] 25 mg 214.30 Anti-Bovine 0oC (LY 83583) 50 mg 413.00 Clone: CPI-50 Purity: 97% Isotype: mouse IgG1 Inhibits nitric oxide induced activation of Conc/Titer: 1:5,000 soluble guanylate cyclase. Also enhances Applications: Immunoblotting; ELISA; contractile responses of rat aorta and artery Immunohistochemistry to α-adrenoceptor agonists. Blocks This antibody reacts strongly with annexin II leukotriene releases and acetylcholine from human or bovine tissues and does not induced relaxation. Reduces cross-react with other annexins or other platelet-endothelial cell adhesion. proteins in a total lysate of human Ref.: 1. Mulsch, A., et.al., fibroblasts as determined by Western Blot. Naunyn-Schmeideberg’s Arch. Pharmacol., It is packaged at a concentration of 1 mg/ml 340, 49 (1989). 2. Macleod, K.M., et.al., in 50% glycerol, 5 mM TRIS, pH8.2, 25 mM Mol. Pharmacol., 32, 59 (1987). 3. Fleisch, NaCl, and 1.5 mM sodium azide. J.H., et.al., J. Pharmacol. Exp. Ther., 229, Purity: ≥95% 681 (1984). The hybridoma was elicited to annexin II C15H10N2O2 MW 250.3 from bovine lung.

ANIRACETAM 10 mg 30.00 193613 [72432-10-1] 25 mg 49.90 RT (Ro 13-5057; 1-(4-Methoxybenzoyl)-2-pyrrolidinone) Reported to increase ion conductance ANNEXIN II, Light Chain through AMPA receptors, and also involve MONOCLONAL ANTIBODY the cholinergic system. Anti-Human Ref.: Toide, Arch. Int. Pharmacodyn., 298, Clone: LC148 25 (1989). Isotype: mouse IgG1 C12H13NO3 MW 219.2 Conc/Titer: 1:5,000 Applications: Immunoblotting; ELISA; Immunohistochemistry This is an 11 kDa light chain of annexin II, usually found tightly associated to annexin II (ICN Code No. 69-155-2). Annexin II is a ANISOMYCIN 10 mg 29.00 structurally unique member of the annexins family because of 159881 [22862-76-6] 25 mg 59.60 this light chain. The other known annexins are monomeric, while -20oC (2-[p-Methoxybenzyl]-3,4- 50 mg 90.00 annexin II is a heterotetramer consisting of two subunits of each pyrrolidinediol 3-acetate) type. From Streptomyces griseolus The antibody is packaged at a concentration of 1 mg/ml in 50% Purity: 97% glycerol, 5 mMTRIS, ph8.2, 25 mM NaCl, and 1.5 mM sodium Activates a restricted subset of kinases azide. currently only identified by p54 and MAP 691582 50 µg 275.60 kinase. Study aid for cytoplasmic signals 100 µg 452.00 resulting in nuclear signaling and induction 691581 of c-fos and c-jun. Ref.: 1. Kavdal, E., et al., Mol. Cell. Biol., 14, 1066 (1994). C14H19NO4 MW 265.3

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ ANNEXIN IV 100 µg 282.90 ANTIPAIN 1 mg 13.75 691561 MONOCLONAL ANTIBODY 152843 [37691-11-5] 5 mg 45.00 -20oC (Anti-Calelectrin 32.5 kDa; anti-endoexin I; -20-0oC ([(S)-1-Carboxy-2-phenylethyl]- 25 mg 160.00 anti-Protein II; anti-Lipocortin IV; carbamoyl-Arg-Val-Arg-al) anti-Chromobindin IV; anti-PAP IV; Source/Species: Microbial anti-PP4-X; anti-Calcimedin 35β) Inhibitor for trypsin, papain, and cathepsins Anti-Human A and B. Clone: CPIII-16 Ref: 1. Suda, H., et al., J. Antibiot., 25, 263 Isotype: mouse IgG1 (1972); 2. Umezawa, H., et al., J. Antibiot., Conc/Titer: 1:5,000 25, 267 (1972); 3. Ikezawa, H., et al., J. Applications: Immunoblotting; ELISA; Antibiot., 25, 738 (1972). Immunohistochemistry C27H44N10O6 MW 604.7 This antibody reacts strongly with annexin IV from human or bovine tissues and does not cross-react with other annexins or other ANTIPAIN 1 mg 8.50 198585 [37682-72-7] 5 mg 19.00 proteins in a total lysate of human o fibroblasts as determined by Western Blot. -20-0 C ([(S)-1-Carboxy-2-phenylethyl]- 25 mg 47.50 It is packaged at a concentration of 1 mg/ml carbamoyl-Arg-Val-Arg-al) 100 mg 150.00 in 50% glycerol, 5 mM TRIS, pH8.2, 25 mM Hydrochloride NaCl, and 1.5 mM sodium azide. Source/Species: Microbial Purity: ≥95% Inhibitor for trypsin, papain, and cathepsins Ref.: 1. Creutz, C.E., et al., J. Biol. Chem., A and B. 262, 1860 (1987). 2. Crompton, M.R., et Ref: 1. Suda, H., et al., J. Antibiot., 25, 263 al., Cell, 55, 1 (1988). (1972); 2. Umezawa, H., et al., J. Antibiot., 25, 267 (1972); 3. Ikezawa, H., et al., J. Antibiot., 25, 738 (1972). ANNEXIN VI C27H44N10O6 • HCl MW 641.2 MONOCLONAL ANTIBODY (Anti-Calelectrin 67 kDa; anti-Lipocortin VI; anti-Protein III; anti-Chromobindin 20; anti-Calcimedin 67 kDa; anti-Calphobindin APAMIN 0.5 mg 75.30 II; anti-p68; anti-p70) 190153 [24345-16-2] 1 mg 135.65 Anti-Human -20oC Bee Venom Clone: 73-5-4 Research Grade Isotype: mouse IgG1 Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-C Conc/Titer: 1:5,000 ys-Ala-Arg-Cys-Gln-Gln-His-NH2. S-S Applications: Immunoblotting; ELISA; Immunohistochemistry bridge between Cys1-Cys11 and Cys3-Cys17. This antibody reacts strongly with annexin VI from human or Ref.: Habermann, E., (1972), Science, 177, bovine tissues and does not cross-react with other annexins or 314-22; Gauldie, J., et. al., (1976), Eur. J. other proteins in a total lysate of human fibroblasts as determined Biochem., 61, 369-76. by Western Blot. It is packaged at a concentration of 1 mg/ml in MW 2027.3 50% glycerol, 5 mM TRIS, pH8.2, 25 mM NaCl, and 1.5 mM sodium azide. Purity: ≥95% APHIDICOLIN 1 mg 56.45 159883 [38966-21-1] 5 mg 223.65 The hybridoma was elicited to annexin VI purified from human o placenta. -20 C From Nigrospora sphaerica 10 mg 403.05 50 µg 391.40 Purity: 98% 691572 Inhibits the early S-phase of the cell cycle. 691571 100 µg 738.65 DNA polymerase α and δ reversible inhibitor. µ Ref.: 1. Levenson, V. and Hamlin, J.L., ANTHRYLMETHYL OKADAATE 10 g 54.45 Nucleic Acids Res., 21, 3997 (1994). 158867 [157606-35-4] 25 µg 108.95 o ≥ 2. O’Dwyer, P.J., et al., Cancer Res., 54, -20-0 C Purity: 98% (HPLC) 50 µg 194.95 724 (1994). A fluorescent derivative of okadaic acid 100 µg 349.70 C H O MW 338.5 used as a standard in okadaic acid analyis. 20 34 4 Ref.: Lee, J.S., et.al., Agric. Biol. Chem., 51, 877 (1987). R(-)-APOCODEINE 25 mg 45.50 C59H78O13 MW 995.3 153635 [641-36-1] 50 mg 74.40 0-5oC (R(-)-10-methoxy-11-hydroxyaporphine) 100 mg 131.00 ANTIBIOTIC A23187 1 mg 20.85 Hydrochloride 152328 [52665-69-7] 5 mg 52.50 Dopamine receptor agonist. o Off-white, photosensitive solid; mp 0-5 C (Calcium Ionophore A23187) 10 mg 83.25 ° ° Free Acid 260-264 C. Store tightly sealed at 4 C, White crystalline solid. away from light. Soluble in water; soluble in alcohol. Antibiotic A23187 is an antibiotic which • demonstrates weak in vitro activity against C18H19NO2 HCl MW 317.7 gram-positive bacteria and fungi. It also has the ability to form stable complexes with 25 mg 11.55 divalent cations, increasing their ability to R(-)-APOMORPHINE 153634 [314-19-2] 50 mg 17.35 cross biological membranes, thus giving o A23187 properties as an ionophore. Its U.V. 0-5 C ((-)-APO HCl; 100 mg 28.85 and fluorescence spectral properties allow R(-)-10,11-dihydroxyaporphine) this calcium ionophore to be useful as a Hydrochloride Dopamine receptor agonist. cytoplasmic free calcium ion probe. A23187 • does exhibit toxicity and is a potential C17H17NO2 HCl MW 303.7 health hazard, so caution should be used when handling, in accordance with normal S(+)-APOMORPHINE 1 mg 67.60 procedures for handling toxic compounds. 153633 [41035-30-7] 2 mg 112.35 C29H37N3O6 MW 523.6 -20-0oC (S(+)-10,11-dihydroxyaporphine) 5 mg 246.55 Hydrochloride ANTIBIOTIC A23187 1 mg 17.15 Dopamine receptor antagonist (inactive as 152329 Mixed Calcium-Magnesium Salt 5 mg 44.20 an agonist). o • 0-5 C C29H37N3O6 MW 523.6 (free acid) 10 mg 80.40 C17H17NO2 HCl MW 303.7

One call. One source. 1155 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ APROTININ 10 mg 50.65 L-ARGININE 25 g 7.90 190382 [9087-70-1] 50 mg 139.05 194626 [74-79-3] 100 g 21.30 0-5oC From Bovine Lung RT Cell Culture Reagent 500 g 69.60 Analytical Grade Free Base Lyophilized white powder Purity: 99% Activity: Approx. 6000 C6H14N4O2 MW 174.2 Kallikrein-inhibitor-units per mg (KIU). Unit Definition: One KIU (Kallikrein ARISTOLOCHIC ACID 50 mg 40.00 Inactivating Unit) is identical to the quantity 159019 [313-67-7] 100 mg 75.40 of protease inhibitor that has the ability to RT From Aristolochiaceae 250 mg 178.50 inhibit 2 Kallikrein units by 50% under Purity: 97% optimal conditions. 1:1 mixture of aristolochic acids I and II. A Ref.: Kunitz, M. and Northrup, J.H., Gen. phenanthrene carboxylic acid derivative Physiol., 19, 991 (1966) which irreversibly blocks phospholipase A2 MW ∼ 6500 from various sources. Ref.: 1. Vishwanath, B.S., et.al., Toxicon, APROTININ 1 mg 9.15 25, 501, 929, 939 (1987). 2. Vishwanath, 191158 [9087-70-1] 5 mg 27.70 B.S., et.al., Inflammation, 12, 549 (1988). 3. 0-5oC From Bovine Lung 10 mg 39.80 Rosenthal, M.D., et.al., Biochem. Biophys. Lyophilized white powder 25 mg 90.00 Acta, 1001, 3 (1989). Activity: 3-4 Inhibitor units/mg of dry 100 mg 277.85 MW 341.3 weight. One Inhibitor unit = 1500 KIU. 250 mg 610.50 ARISTOLOCHIC ACID 50 mg 35.00 APROTININ 10 mg 57.30 159018 Sodium Salt 100 mg 65.00 194559 [9087-70-1] 25 mg 130.70 RT Purity: 97% 250 mg 142.50 0-5oC Cell Culture Reagent 100 mg 403.10 1:1 mixture of aristolochic acid I and From Bovine Lung 250 mg 958.60 aristolochic acid II. Lyophilized white powder MW 363.2 Activity: 3-4 Inhibitor units/mg of dry ASTEMIZOLE 100 mg 18.00 weight. One Inhibitor unit = 1500 KIU. 159886 [68844-77-9] 500 mg 70.00 10 mg 13.30 RT (1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-metho 1 g 124.00 ARACHIDONIC ACID xyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazo 150384 [506-32-1] 50 mg 36.60 o ≥ l-2-amine) 0 C Purity: 98% 100 mg 58.80 Purity: 99% Clear, colorless liquid which may develop a 500 mg 112.00 Selective antagonist for the histamine H1 yellowish cast. 1 g 204.00 receptor. Activates protein kinase C Ref.: 1. Laduron, P.M., et al., Mol. C20H32O2 MW 304.5 Pharmacol., 21, 294 (1982). ARACHIDONIC ACID 10 mg 17.90 2. Richards, D.M., et al., Drugs, 28, 38 194625 [506-32-1] 50 mg 50.10 (1984). 0oC Cell Culture Reagent 100 mg 82.35 C28H31FN4O MW 458.6 Purity: 99% 500 mg 200.30 AURANOFIN 100 mg 49.20 Clear, colorless liquid which may develop a 153961 (S-Triethylphosphine 250 mg 102.40 yellowish cast. RT gold(I)-2,3,4,6-tetra-O-acetyl-1-thio- 500 mg 170.80 C H O MW 304.5 20 32 2 β-D-glucopyranoside) 1 g 284.55 ARACHIDONIC ACID 5 mg 63.05 MW 678.27 159884 10 mg 105.50 o TRIFLUOROMETHYLKETONE AUSTRALINE 1 mg 63.05 -20 C [149301-79-1] 25 mg 235.05 158869 ([(1R, 2R, 3R, 7S, (AACOCF3) 0-5oC 7R)-3-hydroxymethyl-1,2,7-trihydroxypyrroliz Purity: 98% idine]) Arachidonic acid analog which selectively Purity: 99% inhibits human cytosolic phospholipase A2. Inhibitor of amyloglucosidase and Ref.: 1. Street, J.P., et al., Biochemistry, 32, glucosidase I (more selective over 5935 (1993); 2. Bartoli, F., et al., J. Biol. glucosidase II). Chem., 269, 15625 (1994). Ref.: Molyneux, R.J., et.al., J. Nat. Prod., C21H31OF3 MW 356.5 51, 1198 (1988) MW 189 ARCAINE 50 mg 48.50 154794 [36587-93-6] 250 mg 189.65 AUTOCAMTIDE-2 500 µg 55.00 RT (1,4-Diguanidinobutane) 193614 Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-As 1 mg 93.60 Sulfate Salt -20oC p-Ala-Leu Crystalline Purity: >97% NMDA antagonist Very selective CAMKII substrate which C6H16N6 MW 270.3 exhibits no activity towards PKA. Ref.: Hanson, P.I., et al., Neuron, 3, 59 ARECOLINE 5 g 18.00 (1989). 100728 [300-08-3] 10 g 31.00 MW 1526.9 RT Hydrobromide 50 g 132.00 Crystalline (±)-13-AZAPROSTANOIC ACID 1 mg 57.00 Increases levels of acetylcholine in the 154260 Purity: 98% brain. -20oC Crystalline C8H13NO2 • HBr MW 236.1 13-APA antagonizes the actions of thromboxane A2. D-ARGININE 1 g 28.45 Binding to the platelet TXA2/PGH2 receptor 191238 [157-06-2] 5 g 103.60 o is stereospecific and reversible. -20-0 C Free Base MW 311.5 C6H14N4O2 MW 174.20 AZATHIOPRINE 100 mg 9.00 L-ARGININE 100 g 17.45 191364 [446-86-6] 250 mg 14.35 100736 [74-79-3] 500 g 55.90 0oC (6-[(1-Methyl-4-nitroimidazol-5-yl)- 1 g 44.00 RT Free Base 1 kg 93.15 thio] purine) 5 g 171.30 Crystalline Crystalline Purity: 99% Immunosuppresive and cytostatic agent. C6H14N4O2 MW 174.2 C9H7N7O2S MW 277.3 To place an order: (800) 854-0530, fax (800) 334-6999 1156 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ (R)-2-AZIDO-N6-p-HYDROXY- 2 mg 36.15 BENZAMIL 1 mg 6.95 153632 PHENYLISOPROPYLADENOSINE 5 mg 65.10 159795 [2898-76-2] 5 mg 13.00 0-5oC [98897-11-1] 10 mg 115.70 RT (Benzylamiloride hydrochloride) 25 mg 56.50 [(R)AHPIA] Hydrochloride + Photoaffinity ligand for the A1 Adenosine Potent Na -channel blocker. receptor. C13H14N7OCl • HCl MW 356.2 C19H22N8O5 MW 442.4 ± 5 mg 11.75 25 mg 321.05 ( )-BENZETIMIDE 7-AZIDOKETANSERIN 150433 (3-phenyl-3-[1-(phenylmethyl)-4-piperidinyl]-2 10 mg 48.10 158870 (R 63836) 50 mg 584.75 0oC , 6- piperidinedione; R4929) 25 mg 49.90 RT Purity: 99% Hydrochloride Photoaffinity probe for 5-HT and histamine Ref.: (1) Resolution of isomers and receptors. pharmacology: van Wijngaarden, Life Sci., Ref.: 1. Wouters, W., et.al., FEBS, 182, 291 8, 517 (1969); (2) van Wijngaarden, (1985). 2. Wouters, W., et.al., J. Biol. Soudijn, Life Sci., 7, 225 (1968). Chem., 260, 8423 (1985). MW 436.4 BENZOQUINONIUM DIBROMIDE 1 mg 21.20 159724 [311-09-1] 5 mg 84.85 -B- RT Nicotinic antagonist that blocks ganglion. 10 mg 155.90 BACCATINE III 1 mg 21.95 C34H50N4O2Br2 MW 706.6 159793 [27548-93-2] 5 mg 73.15 0-5oC Starting material for taxol derivatives. 10 mg 135.00 BENZOTRIPT 100 mg 122.50 Ref.: Wheeler, N.C., J. Natl. Prod., 55, 432 151443 [39544-74-6] 500 mg 340.05 (1992). RT (N-[4-chlorobenzoyl]-L-tryptophan) C31H38O11 MW 586.6 Selective cholecystokinin antagonist; 5 mg 166.95 gastrin receptor antagonist. BACCATINE III-7,13-DIACETATE Ref.: Magous, et al., Regul. Pept., 7, 233 159794 Distinguishes between mammalian and o (1983). 0-5 C amoebic microtubules. C H N O Cl MW 342.8 Ref.: Lataste, H., et al., Proc. Natl. Acad. 18 15 2 3 Sci. USA, 81, 4090 (1984). 25 mg 10.10 C35H42O13 MW 670.7 BENZTROPINE MESYLATE 153626 [132-17-2] 100 mg 28.85 (±)-BACLOFEN 100 mg 11.00 RT (3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[ 153629 [1134-47-0] 500 mg 16.00 3.2.1]octane methane sulfonate) RT ((±)-β-(Aminoethyl)-4- Crystalline chlorobenzenepropanoic acid) Muscarinic receptor antagonist. White solid; mp 192-193°C. Store tightly C22H29NO4S MW 403.5 sealed. Soluble in water, dilute acid and base. N6-BENZYLADENOSINE 100 mg 9.95 C10H12NO2Cl MW 213.7 150449 [4294-16-0] 250 mg 18.00 o 14 µ 0 C (6-Benzylaminopurine riboside) (-)-BACLOFEN, [Butyl-4- C(U)] 50 Ci 1308.55 Crystalline 16030 Sp. Act. 50-60 mCi/mmol o An A1 Adenosine receptor agonist. 0-5 C 1.85-2.22 GBq/mmol C H N O MW 357.4 Ethanol:water (7:3). 17 19 5 4 Please call for delivery information. p-ClC6H5CH(CH2CO2H)CH2NH2 N-BENZYL-3,4-DIHYDROXY-α-CYANOCINNAMIDE MW 213.67 See: Tyrphostin B42 (-)-BACLOFEN, [Butyl-4-3H] 250 µCi 787.10 26024 Sp. Act. 30-60 Ci/mmol 6 ′′′ 1 mg 22.05 o N -BENZYL-5 -N- 0-5 C 1.11-2.22 TBq/mmol 193615 ETHYLCARBOXAMIDOADENOSINE 5 mg 82.70 Ethanol:water (7:3). 0-5oC (N6-Benzyl-NECA) Please call for delivery information. An A3 Adenosine receptor agonist. p-ClC6H5CH(CH2CO2H)CH2NH2 Ref.: Gallo-Rodriquez, et al., J. Med. Chem., 37, 636 (1994). BAFILOMYCIN A1 10 µg 88.90 159555 [88899-55-2] 25 µg 183.45 C19H22N6O4 MW 398.4 0oC From Streptomyces griseus Purity: ∼90% 1-BENZYL-1-METHYL-4-CYCLOPENTYLMETHOXY- ATPase inhibitor. CARBONYLPIPERIDINIUM BROMIDE C35H58O9 MW 622.8 See: BMCP BAICALEIN 5 mg 33.20 159067 [491-67-8] 10 mg 60.70 0oC (5,6,7-Trihydroxyflavone) 50 mg 255.00 BENZYLOXYAMINE 1 g 12.65 Purity: 98% 104861 [2687-43-6] 5 g 30.00 Specifically inhibits 12-lipoxygenase and RT (O-Benzylhydroxylamine) 25 g 120.00 leukotriene biosynthesis. Hydrochloride Crystalline Ref.: Kimura, Y., et.al., Biochim. Biophys. β Acta, 922, 278 (1987). Dopamine -hydroxylase inhibitor. C H O MW 270.2 Derivatizing reagent for GLC analysis of 15 10 5 ketosteroids. (±)-BAY K 8644 1 mg 30.00 C7H9NO • HCl MW 159.6 153628 [98791-67-4] 2 mg 55.00 0-5oC (1,4-Dihydro-2,6-dimethyl-5-nitro-4- 5 mg 116.50 BENZYLPHOSPHONIC ACID 50 mg 17.20 [2-(trifluoromethyl)-phenyl]-3-pyridine- 159893 [6881-57-8] 100 mg 28.65 carboxylic acid methyl ester) RT Purity: 98% 500 mg 91.70 C16H15F3N2O4 MW 356.3 Structural mimic of phosphotyrosine. 100 mg 53.00 Inhibits bovine heart tyrosine-protein BENSERAZIDE phosphatase. Not cell permeable. 154261 [14919-77-8] 500 mg 238.00 o Ref.: Zhand, Z.-Y. and Van Etten, R.L., -20 C Hydrochloride Arch. Biochem. Biophys., 282, 39 (1990). Tan solid MW 172.1 C10H15N3O5 • HCl MW 293.7 One call. One source. 1157 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $

BENZYLPHOSPHONIC ACID-(AM)2 10 mg 103.20 (-)-BICUCULLINE 50 µCi 969.00 159894 (Benzylphosphonic acid bis-acetoxymethyl 16031 METHYLCHLORIDE, [Methyl-14C] -20oC ester) 0-5oC Sp. Act. 50-60 mCi/mmol Purity: 98% 1.85-2.22 GBq/mmol Cell permeable tyrosine phosphatase Ethanol under nitrogen inhibitor. Shipped in dry ice. MW 316.3 Please call for delivery information. BEPRIDIL 15 mg 40.00 MW 417.8 153627 [74764-40-2] 25 mg 53.00 (-)-BICUCULLINE 250 µCi 726.45 RT Hydrochloride 50 mg 94.00 26025 METHYLCHLORIDE, [Methyl-3H] 1 mCi 1939.20 A non-selective calcium channel blocker. o • 0-5 C Sp. Act. 60-90 Ci/mmol C24H34N2O HCl MW 403 2.22-3.33 TBq/mmol E6 BERBAMINE 5 mg 80.25 Ethanol under nitrogen 159895 Purity: 98% 10 mg 137.60 Shipped in dry ice. -20oC A selective and potent cell permeable Please call for delivery information. antagonist of calmodulin. 25 mg 36.40 Ref.: Hu, Z.-Y., et al., Biochem. Pharmacol., BIOALLETHRIN 158873 [22431-63-6] 50 mg 69.20 44, 1543 (1992). o MW 757.8 -20-0 C (D-trans-Allethrin) Mixture of isomers BERBERINE 1 g 10.15 Bioallethrin is a Type I pyrethrin and it 195857 [633-65-8] 5 g 20.00 mimics Type II pyrethrins on the inhibition of RT (Natural Yellow 18; C.I. 75160) 25 g 80.00 calcineurin (protein phosphatase 2B). It is a Chloride more potent inhibitor of calcineurin than Apoptosis Inhibitor. allethrin and other Type I pyrethrins. C20H18NO4Cl MW 371.8 C19H26O3 MW 302.42 BESTATIN 1 mg 16.95 BISINDOLYLMALEIMIDE I 250 µg 28.60 152844 [58970-76-6] 5 mg 50.15 194137 [133052-90-1] 1 mg 85.00 -20-0oC ([(2S,3R)-3-Amino-2-hydroxy-4-phenylbutano 10 mg 83.60 0-5oC (GF109203X) yl]-Leu) 25 mg 156.50 Purity: 98% Free Acid Hydrochloride Inhibitor for aminopeptidase B and leucine Protein Kinase C inhibitor. aminopeptidase. Ref.: Davis, P.D., et al., J. Med. Chem., 35, Ref: Umezawa, H., et al., J. Antibiot., 29, 994 (1992). 97 (1976). C25H24N4O2 • HCl MW 449.0 C16H24N2O4 MW 308.4 BISINDOLYLMALEIMIDE I 250 µg 66.15 BETAXOLOL 5 mg 74.95 194138 (GF109203X) 1 mg 232.00 193616 [63659-19-8] 25 mg 303.20 0-5oC Purity: 98% RT Hydrochloride Highly selective Protein Kinase C inhibitor. A selective β1-adrenoceptor antagonist. Ref.: Toullec, D., et al., J. Biol. Chem., 266, C18H29NO3 • HCl MW 343.9 15771 (1991). BETAXOLOL 5 mg 74.95 C25H24N4O2 MW 411.5 198588 [63659-19-8] 25 mg 303.20 BISINDOLYLMALEIMIDE II 250 µg 82.70 RT Hydrochloride 194139 (2-(1-[2-(1-Methylpyrrolidino)ethyl]-1H-indol-3 1 mg 216.10 Monohydrate 0-5oC -yl-3-(1H-indol-3-yl)maleimide) A selective β1-adrenoceptor antagonist. • • Purity: 95% C18H29NO3 HCl H2O MW 352.9 Potently and selectively inhibits Protein BETHANECHOL CHLORIDE 5 g 19.85 Kinase C. 190160 [590-63-6] 25 g 62.00 Ref.: Toullec, D., et al., J. Biol. Chem., 266, 0-5oC (Carbamyl-β-methylcholine chloride) 100 g 201.35 15771 (1991). Cholinergic receptor agonist C27H26N4O2 MW 438.5 C7H17N2O2Cl MW 196.7 BLANKOPHOR 10 ml 23.10 BETULINIC ACID 1 mg 39.90 196040 [16470-24-9] 25 ml 51.00 195859 [472-15-1] 5 mg 152.25 RT (Benzenesulfonic acid, 100 ml 181.00 0-5oC (3β-Hydroxy-20(29)-lupaene-28-oic acid) 2,2′-(1,2-ethenediyl)bis[5-[[4-[bis(2-hydroxyet Purity: ≥97% hyl)amino]-6-[(4-sulfophenyl)amino]-1,3,5-tria Selectively inhibits human melanoma in cell zin-2-yl]amino]-tetrasodium salt) culture and in animal models and Purity: ≥90% demonstrates antitumor properties by A highly selective fluorescent probe of inducing apoptosis. Possess anti-HIV β-amyloid and amyloid plaque core protein properties. (APCP). It does not fade during prolonged C30H48O3 MW 456.7 exposure to UV blue exciting light. Ref.: Roher, A., et al., Proceed. Nat. Acad. (+)-BICUCULLINE 100 mg 29.10 of Sci., 83, 2662-2666 (1986). 190789 [485-49-4] 250 mg 57.40 0oC Crystalline 500 mg 109.45 BOMBESIN 1 mg 61.00 GABA blocker. 1 g 166.40 190307 [31362-50-2] 5 mg 266.00 o C20H17NO6 MW 367.4 -20-0 C (pyroGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-V al-Gly-His-Leu-Met-NH2) (-)-BICUCULLINE METHOBROMIDE 25 mg 25.25 A tetradecapeptide that has biological 158872 [73604-30-5] 100 mg 75.00 o activities in the central nervous system and 0-5 C Purity: 98% 250 mg 179.50 gastrointestinal tract; also has GABAA antagonist. thermoregulatory effects. Ref.: Hill, D.R. and Bowery, N.G., Nature, Ref.: 1. Bertaccini, G., et al., Br. J. 290, 149 (1981) • Pharmac., 52, 219 (1974). C21H20NO6 Br MW 462.3 2. Erspamer, V., et al., Br. J. Pharmac., 52, (-)-BICUCULLINE METHOCHLORIDE 5 mg 20.00 227 (1974). 159726 [53552-05-9] 10 mg 31.00 3. Rivier, J.E. and Brown, M.R., 0-5oC A water soluble GABA antagonist. 25 mg 65.50 Biochemistry, 17, 1776 (1978). C21H20NO6Cl MW 417.8 C71H110N24O18S MW 1619.9 To place an order: (800) 854-0530, fax (800) 334-6999 1158 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ BOROGLYCINE 5 mg 198.50 8-BROMOADENOSINE-3′′′,5′′′-cyclic- 10 mg 40.00 154608 (Ammonia-carboxyborane) 15 mg 407.35 158877 MONOPHOSPHATE 25 mg 75.00 0oC Purity: >97% -20-0oC [76939-46-3] 50 mg 145.00 Potent hypocholesterolemic agent. Sodium Salt 100 mg 276.00 β-Hydroxy-β-methylglutaryl-CoA reductase Purity: 98% inhibitor. cAMP analog more resistant to Ref.: I.H. Hall, M.K. Das, F. Harchelroad, phosphodiesterases than cAMP. Activates Jr., P. Wisian-Neilson, A.T. McPhail and B.F. cAMP-dependent protein kinase. Spielvogel, J. Pharm. Sci. 70, 339 (1981). Ref.: 1. Meyer, R.B. and Miller, J.P., Life BCH6NO2 MW 74.88 Sci., 14, 1019 (1974). 2. Hei, Y.-J., et.al., Mol. Pharmacol., 39, BOROSARCOSINE 5 mg 198.50 223 (1991). 154609 (Boromethylglycine, 15 mg 407.35 3. Sandberg, M., et.al., Biochem. J., 279, 0oC methylamine-carboxyborane) 521 (1991). Purity: >97% C10H10BrN5O6PNa MW 430.1 Dihydrofolate reductase inhibitor, DNA BROMOBIMANE 5 mg 21.00 polymerase inhibitor. 159729 [71418-44-5] 25 mg 80.50 Ref.: I.H. Hall, C.J. Gilbert, A.T. McPhail, -20-0oC Substrate for glutathionetransferase and K.W. Morse, K. Hassett and B.F. Spielvogel, fluorescent labeling reagent for Thiols. J. Pharm. Sci., 74, 755 (1985). C10H11N2O2Br MW 271.1 BC2H8NO2 MW 88.9 N-[2-(p-BROMOCINNAMYL- 5 mg 68.75 µ 158878 10 mg 131.90 BRAIN DERIVED NEUROTROPHIC 5 g 180.50 o AMINO)ETHYL]-5-ISO- 193950 FACTOR 0 C QUINOLINESULFONAMIDE 25 mg 313.00 -20oC (BDNF) [127243-85-0] Human, Recombinant (H-89) Purity: ≥95% Dihydrochloride Produced in E. coli Purity: 99% A neurotrophin which promotes sensory Specific and potent inhibitor of PKA. ganglions and motor neurons survival and Ref.: Nishizuka, Y., Science, 233, 305 differentitation. (1986). MW ∼28 kDa MW 519.2 BROMOCONDURITOL BREFELDIN A 5 mg 67.80 159027 [20350-15-6] 25 mg 268.15 See: 6-Bromo-4-cyclohexene-1,2,3-triol -20oC (γ,4-Dihydroxy-2-[6-hydroxy-1-heptenyl]-4-cy clopentanecrotonic acid λ-lactone; BFA) (+)-BROMOCRIPTINE MESYLATE 10 mg 19.10 Purity: 98% 153758 [22260-51-1] 25 mg 27.10 0-5oC (2-Bromo-12′-hydroxy-2′- 100 mg 72.50 Blocks binding of the cytosolic coat protein ′ β-COP and ARF to Golgi membranes (1-methylethyl)-5 -(2-methyl- mediated by protein G. Also blocks protein propyl)ergotaman-3′,6′,18-trione transportation into post-Golgi methanesulfonate) Methanesulfonate Salt compartments. • Ref.: 1. Donaldson, J.G., et.al., Science, C32H40N5O5Br CH4SO3 MW 750.7 254, 1197 (1991). 6-BROMO-4-CYCLOHEXENE-1,2,3- 1 mg 11.00 2. Donaldson, J.G., et.al., J. Cell. Biol., 112, 158879 TRIOL 5 mg 48.70 579 (1991). 0-5oC [42014-74-4] 3. Orci, L., et.al. Cell, 64, 1183 (1991). (6-Bromo-3,4,5-trihydroxycyclohex-1-ene; 4. Lippincott-Schwartz, J., et.al., ibid., 60, Bromoconduritol) 821 (1990). Purity: 99% C16H24O4 MW 280.4 Mixed isomers α 3 Inhibitor of mammalian -glucosidase II BREFELDIN A, [ H] 250 µCi Enquire over α-glucosidase I. 26026 Sp. Act. 15-30 Ci/mmol o Ref.: Datema, R., et.al., Proc. Natl. Acad. 0-5 C 0.555-1.11 TBq/mmol Sci. USA, 79, 6787 (1982). Ethanol C6H9BrO3 MW 209 Please call for delivery information. MW 280.37 8-BROMOGUANOSINE-3′′′,5′′′-cyclic- 5 mg 21.90 158880 10 mg 37.80 o MONOPHOSPHATE BREVETOXIN PbTx-1 100 µg 382.00 -20-0 C [51116-01-9] 25 mg 87.00 195711 [98112-41-5] (8-Bromo-cGMP) -20-0oC From Ptychodiscus brevis Sodium Salt Purity: ≥95% Purity: 96% Voltage-dependent sodium channel Activates cGMP-dependent protein kinase. activator. Inhibitor of thrombin induced arachidonic CAUTION! HIGHLY TOXIC! acid release in human platelets. MW 866.6 Ref.: 1. Meyer, R.B. and Miller, J.P., Life Sci., 14, 1019 (1974). 2. Francis, S.G., µ 116.00 et.al., ibid., 34, 506 (1988). 3. Schultz, K.D., BREVETOXIN PbTx-9 10 g et.al., Naunyn-Schmiedeberg’s Arch. 158876 From Ptychodiscus brevis 25 µg 290.00 o ≥ µ Pharmacol., 306, 1 (1979). 4. Sane, D.C., -20-0 C Purity: 95% 50 g 504.00 et.al., Biochem. Biophys. Res. Commun., Cyclic polyether which causes contractile 165, 708 (1989). paralysis in animal models. Do not use C H BrN O PNa MW 446.1 DMSO as a solvent. 10 10 5 7 MW 898.6 (RS)-4-BROMOHOMOIBOTENIC ACID 1 mg 24.25 193617 [71366-32-0] 5 mg 97.00 BROMOACETYL ALPRENOLOL 15 mg 40.55 RT A potent AMPA receptor agonist. Unlike 10 mg 187.40 153759 MENTHANE 25 mg 72.25 AMPA, it also shows affinity for 0oC [76298-90-3] 50 mg 137.45 CaCl2-dependent L-glutamate binding sites. A β-adrenergic antagonist Ref.: Chung, et al., J. Neurochem., 63, 133 C24H37BrN2O3 MW 481.5 (1994). C6H7N2O4Br MW 251.0 One call. One source. 1159 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 3-BROMO-7-NITROINDAZOLE 10 mg 52.25 BUPROPION 15 mg 27.10 193620 [74209-34-0] 25 mg 76.00 153760 [31677-93-7] 25 mg 38.10 -20oC Purity: ≥97% RT ((±)-1-(3-Chlorophenyl)-2- 50 mg 70.75 More potent inhibitor of nitric oxide [(1,1-dimethylethyl)amino]- synthase (NOS) than 7-nitroindazole. 1-propanone hydrochloride) C7H4N3O2Br MW 242.0 Hydrochloride Dopamine uptake inhibitor (+)-p-BROMOTETRAMISOLE 25 mg 61.00 C13H18NOCl • HCl MW 276.2 152407 [71461-24-0] 100 mg 224.00 0-5oC ((+)-6(4-bromophenyl)-2,3,5,6-tetrahydroimid BUSPIRONE 1 g 35.00 154905 [33386-08-2] 5 g 154.00 azo[2,1-b]thiazole ethanedioate) o Oxalate Salt 0-5 C (N-[4-(4-[2-Pyrimidinyl]-1-piperazinyl)butyl]-8- Purity: 99% azaspiro[4, 5]decane-7, 9-dione) An alkaline phosphate inhibitor. Shown to Hydrochloride A 5-HT1A Serotonin receptor agonist exhibit slightly less potent inhibition than • (-)-p-Bromotetramisole make the dextro (+) C21H31N5O2 HCl MW 422 form ideal for internal control applications. • (+)-BUTACLAMOL 5 mg 34.40 C11H11BrN2S C2H2O4 MW 373.2 153623 Hydrochloride 25 mg 150.00 RT D1/D2 Dopamine antagonist 50 mg 285.00 25 mg 71.30 (-)-p-BROMOTETRAMISOLE C25H31NO • HCl MW 398 152408 [62284-79-1] 100 mg 177.95 0-5oC ((-)-6(4-bromophenyl)-2,3,5,6-tetrahydroimida 4-(3-BUTOXY-4-METHOXYBENZYL)-2- 100 mg 43.00 zo[2,1-b]thiazole ethanedioate; R 30402) 158881 IMIDAZOLIDINONE 500 mg 172.35 Oxalate Salt RT [29925-17-5] Purity: 99% (Ro 201724) A potent alkaline phosphate inhibitor. Purity: 99% (-)-p-Bromotetramisole has been shown to Strong inhibitor of cAMP specific function more effectively in the quantitative phosphodiesterase. Use in cell culture has determination of intestinal and placental been demonstrated with a blood brain isoenzymes of alkaline phosphatase in barrier model. human serum than the more commonly Ref.: 1. Sheppard, H., et.al., Adv. Cyclic used L-phenylalanine. Nucleotide Res., 1, 103 (1972). 2. Reeves, C11H11BrN2S • C2H2O4 MW 373.2 M.L., et.al., Biochem. J., 241, 535 (1987). 3. Katano, y. and Endoh, M., Biochem. BRYOSTATIN 1 10 µg 156.00 Biophys. Res. Commun., 167, 123 (1990). 159558 [83314-1-6] 4. Rubin, L.L., et.al., J. Cell Biol., 115, 1725 0oC Activates Protein Kinase C. (1991). C47H66O16 MW 887.0 C15H22N2O3 MW 278.4 BRYOSTATIN 2 25 µg 395.00 t-BUTYL-BICYCLO[2.2.2] 1 mg 108.45 153550 PHOSPHOROTHIONATE 2 mg 185.00 159559 [87745-28-6] o 0oC Binds to and activates Protein Kinase C. 0-5 C [70636-86-1] (TBPS) BUCCALIN 1 mg 72.25 A GABAA receptor antagonist, and chloride 154475 [116844-51-0] 5 mg 289.20 channel blocker 0-5oC (Modulatory Neuropeptide) C8H15O3PS MW 222.4 H2N-Gly-Met-Asp-Ser-Leu-Ala- 3-tert-BUTYL-5-METHOXY-1,2- 10 mg 29.00 Phe-Ser-Gly-Gly-Leu-NH2 193743 QUINONE 25 mg 65.00 Ref.: Cropper, E.C., et al., (1988), PNAS, RT [2940-63-8] 50 mg 121.00 85, 6177 Cytotoxic agent to P388 and KB cells. MW 1053.3 Ref.: Lam, L.K.T., J. Pharm. Sci., 77, 393-5 (1988). (+)-BULBOCAPNINE 05 mg 25.00 C H O MW 194.3 153761 [632-47-3] 10 mg 48.00 11 14 3 RT Hydrochloride BUTYROLACTONE I 1 mg 126.80 Dopamine antagonist 195601 (α-oxo-β(p-Hydroxyphenyl)-γ-(p-hydroxy-m-3 5 mg 527.00 o C19H19NO4 • HCl MW 361.8 0-5 C ,3-dimethylallylbenzyl)-γ-methoxycarbonyl-γ- butrylactone) (+)-BULBOCAPNINE 10 mg 63.00 Purity: >99% 153762 [298-45-3] 15 mg 89.25 A selective inhibitor of cdk2 and cdc2 RT Dopamine antagonist 25 mg 144.60 kinase. C19H19NO4 MW 325.3 DO NOT STERILIZE. C24H24O7 MW 424 BUMETANIDE 250 mg 16.20 154263 [28395-03-1] 1 g 46.30 -C- 0-5oC White micronized solid 5 g 194.75 Purity: 99% C3 EXOENZYME 10 µg 262.50 195680 From Clostridium botulinum An inhibitor of sodium and potassium o cotransport. -20 C Lyophilized C17H20N2O5S MW 364 Useful for Rho and related protein function analysis including lymphocyte-mediated α-BUNGAROTOXIN 500 µg 62.10 cytotoxicity, cell motility and 193621 [11032-79-4] 1 mg 116.50 thrombin-induced platelet aggregation. It -20oC A neurotoxin that irreversibly binds to selectively ADP-ribosylates G proteins of post-synaptic cholinergic receptors, low molecular weight. producing neuromuscular blockade and CAFESTOL 10 mg 30.85 skeletal muscle paralysis. Useful as a 193745 [469-83-0] 25 mg 63.95 probe for acetylcholine receptors. 0-5oC From Coffee Beans 50 mg 111.35 Isolated from Bungarus multicinctus snake A natural extract which induces glutathione 100 mg 192.95 venom. S-transferase. Ref.: Mebs, et al., Biochem. Biophys. Res. Ref.: Lam, L.K.T., et al., Cancer Res., 42, Comm., 44, 711 (1971). 1193-98 (1982). MW 7907.2 C20H28O3 MW 316.4 To place an order: (800) 854-0530, fax (800) 334-6999 1160 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ CAFESTOL PALMITATE 10 mg 32.00 CALMODULIN 1 KU 13.65 193747 [81760-46-5] 25 mg 70.00 195692 [73298-54-1] 5 KU 21.00 0-5oC A naturally occurring ester present in green 50 mg 135.00 -20oC (Phosphodiesterase 3,5′-cyclic-Nucleotide 25 KU 92.00 coffee beans. 100 mg 250.00 Activator) 100 KU 350.00 Ref.: Lam, L.K.T., et al., Cancer Res., 42, From Bovine Brain 1193-98 (1982). Purity: ≥98% C36H58O4 MW 554.4 Lyophilized virtually salt free. Activity: >40,000 units/mg CAFFEIC ACID 1 g 7.40 Unit Definition: one unit will activate 0.016 104797 [331-39-5] 5 g 18.00 units of 3′,5′-cyclic-nucleotide RT (3,4-Dihydroxycinnamic acid) 25 g 62.15 phosphodiesterase to 50% Vmax when Yellowish-brown crystals saturated with activator in the presence of C9H8O4 MW 180.2 0.01mM Ca2+. It may be used to activate CaM-dependent phosphodiesterase, CAFFEIC ACID PHENETHYL ESTER 1 mg 10.50 calcineurin, CaM Kinases, etc. 195860 [104594-70-9] 5 mg 40.85 -20oC (CAPE) Purity: ≥97% CALMODULIN 1 KU 10.50 Active component of propolis from 195696 [77107-46-1] 5 KU 21.35 honeybee hives. Possesses anti-viral, -20oC (Phosphodiesterase 3,5′-cyclic-Nucleotide 25 KU 56.60 anti-inflammatory and immunomodulary Activator) properties. Inhibits growth of several types From Porcine Brain of transformed cells and induces apoptosis Purity: ≥95% in cloned rat embryo fibroblast (CREF) cells. Lyophilized virtually salt free. C17H16O4 MW 284.3 Activity: >40,000 units/mg Unit Definition: one unit will activate 0.016 CAFFEINE 100 g 8.15 units of 3′,5′-cyclic-nucleotide 101194 [58-08-2] 250 g 17.50 phosphodiesterase to 50% Vmax when RT (1,3,7-Trimethylxanthine) 500 g 29.80 saturated with activator in the presence of Monohydrate 1 kg 49.65 0.01mM Ca2+. It may be used to activate Protects against virus induction and CaM-dependent phosphodiesterase, chemical carcinogenesis. calcineurin, CaM Kinases, etc. Ref.: Rothwell, K., (1974), Nature, 252, 69-70; Yosh-Kura, H., (1974), Nature, 252, 71. CALMODULIN 1 mg 183.00 ′ C8H10N4O2 • H2O MW 212.2 195894 (Phosphodiesterase 3,5 -cyclic-Nucleotide 0-5oC Activator) CAFFEINE 100 g 13.95 Chicken, Recombinant 150114 [58-08-2] 250 g 27.90 Expressed in E. coli RT (1,3,7-Trimethylxanthine) 500 g 46.50 Purity: ≥95% Anhydrous 1 kg 77.40 Activity: will activate nitric oxide synthase. C8H10N4O2 MW 194.2 MW 16,700 CALCINEURIN 50 U 171.00 150545 (Calmodulin binding protein) 100 U 332.00 CALMODULIN 1 ml 220.75 o 657821 0 C (Modulator binding protein) o POLYCLONAL ANTIBODY From Bovine Brain -20 C Anti-Bovine Lyophilized powder containing approx. 1% Host: goat protein (Lowry) the balance primarily Form: delipidized pooled antiserum buffers, salts and stabilizers. Conc/Titer: 1:100 Unit Definition: One unit will cause 50% Applications: Western Blot inhibition of the activated The antiserum was produced in goats by inoculation with of purified bovine brain phosphodiesterase 3′-5′ cyclic nucleotide 2+ activity when assayed in two units of calmodulin. Calmodulin is a small Ca activator and 0.1 mM Ca2+ in an enzyme binding protein with a molecular weight of coupled system. 17,000 daltons, identified in all animal and plant cells that have been examined. It is CALMIDAZOLIUM 5 mg 40.00 involved in the control of a large number of 190074 [57265-65-3] 10 mg 70.00 cellular metabolic reactions and many RT (Compound R24571, [1-bis-p-chlorophenyl) 25 mg 163.00 processes associated with the cytoskeletal methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyl contractile apparatus such as the control of oxy) phenyl]-imidazolium chloride) myosin light chain kinase activity which Calmidazolium inhibits the Ca2+ calmodulin regulates myosin contraction in smooth dependent PDE. Approx. 500 times more muscle and non-muscle cells. powerful than trifluoperazine. Ref.: Van Belle, H. (1981) in "Cell Calcium" 2, 483-494. CALMODULIN-DEPENDENT PROTEIN KINASE C31H23Cl7N2O MW 687.7 SUBSTRATE See: Syntide 2 CALMODULIN 1 mg 154.00 195691 [73298-54-1] o -20 C (Phosphodiesterase 3,5′-cyclic-Nucleotide CALMODULIN DEPENDENT PROTEIN 250 U 25.20 Activator) 195895 KINASE II-α 1 KU 73.50 From Bovine Brain -70oC ≥ (CaM Kinase II) Purity: 99% Rat, Recombinant Lyophilized with 1.7 mM HEPES, pH7, 30 α µ -Subunit M CaCl2 Involved in modulating neurite outgrowth of Activity: 13,000 units/mg the cAMP system. Unit Definition: one unit will activate Activity: 250,000 units/ml 3′,5′-cyclic-nucleotide phosphodiesterase Unit Definition: one unit will catalyze the to 50% Vmax. It may be used to activate transfer of 1 pmol of phosphate to CaM-dependent phosphodiesterase, KRQQSFDLF per minute at 30°C, pH 7.5. calcineurin, CaM Kinases, etc. MW 33 kDa MW 16.7 kDa

One call. One source. 1161 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ CALMODULIN-DEPENDENT 100 µg 90.55 CAMPTOTHECIN 25 mg 17.00 159561 PROTEIN KINASE II (281-309) 159732 [7689-03-4] 50 mg 30.00 0oC Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Ly 0-5oC Purity: 97% 100 mg 55.00 s-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly- Binds to and stabilizes the 250 mg 130.00 Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala topoisomerase-DNA covalent complex Potent inhibitor of calmodulin-dependent which reversibly inhibits nuclear protein kinase II. topoisomerase I. Also, inhibits Ref.: Colbran, R.J., et al., J. Biol. Chem., TAT-mediated HIV-1 trasactivation. 208, 18145 (1988). Ref.: 1. Hertzberg, R.P., et al., Biochem. J., 28, 4629 (1990). µ 2. Hsiang, Y.H., et al., J. Biol. Chem., 260, CALMODULIN-DEPENDENT 100 g 59.65 14873 (1985). 159562 PROTEIN KINASE II (290-309) o 3. Li, C.J., et al., J. Biol. Chem., 269, 7051 0 C [115044-69-4] (1994). Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-L C20H16N2O4 MW 348.4 ys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala Inhibitor of Ca2+/Calmodulin-dependent CAMPTOTHECIN, [3H(G)] 1 mCi 1696.65 protein kinase II 26027 Sp. Act. 100-500 mCi/mmol Ref.: Payne, M.E., et al., J. Biol. Chem., 0-5oC 3.70-18.5 GBq/mmol 263, 7190 (1988). Solid under argon. Please call for delivery information. CALPAIN INHIBITOR I 1 mg 13.75 MW 348.34 158834 [110044-82-1] 5 mg 57.35 o L-CANAVANINE SULFATE 100 mg 10.75 0-5 C (N-Ac-Leu-Leu-Norleucinal) 10 mg 103.20 100186 [2219-31-0] 250 mg 26.00 Purity: 98% 0-5oC Crystalline 1 g 99.85 An inhibitor of both Calpain I and II Isolated from Jack Beans (calcium-dependent cysteine proteases). Inhibits arginine metabolism, and is a Has been reported to be useful in the study substrate in certain transamidination of cytoskeletal and muscle protein turnover. reactions. Decomposed by strong acids Ref: 1) Murachi, T., Trends Biochem. Sci., and light. Soluble in chloroform, acetone 8, 167 (1983). 2) Yoshimura, et.al., J. Biol. and methanol. Chem., 258, 8883 (1983). C H N O • H SO MW 274.2 MW 383.5 5 12 4 3 2 4 CANTHARIDIC ACID 5 mg 44.15 158883 [28874-45-5] 10 mg 83.65 CALPAIN INHIBITOR II 1 mg 13.75 o 158835 [136632-32-1] 5 mg 57.35 -20-0 C C10H14O5 MW 214.2 0-5oC (N-Ac-Leu-Leu-Methioninal) 10 mg 103.20 Purity: >98% CANTHARIDIN 25 mg 45.90 158884 [56-25-7] 100 mg 143.30 An inhibitor of both Calpain I and II o (calcium-dependent cysteine proteases). -20-0 C C10H12O4 MW 196.2 Has been reported to be useful in the study of cytoskeletal and muscle protein turnover. CAPSAICIN Ref: 1) Murachi, T., Trends Biochem. Sci., 8, 167 (1983). 2) Yoshimura, et.al., J. Biol. See: 8-Methyl-N-vanillyl-6-nonenamide Chem., 258, 8883 (1983). MW 403.6 CAPSAZEPINE 1 mg 22.95 159796 [138977-28-3] 5 mg 91.70 RT (N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahyd CALPEPTIN 5 mg 72.00 ro-7,8-dihydroxy-2H-2-benzazepine-2-carbot 159563 [117591-20-5] 10 mg 131.00 o hioamide) 0 C (N-CBZ-L-Leucyl-Norleucinal) A competitive antagonist for capsaicin and Inhibitor of Calpain and Cathepsin L. resiniferatoxin. Ref.: Sasaki, et al., J. Enz. Inhib., 3, 195 C19H21N2O2SCl MW 376.9 (1990). C20H30N2O4 MW 362.5 CARBACHOL See: Carbamylcholine Chloride CALPHOSTIN C 100 µg 113.95 158882 [121263-19-2] o CARBACYCLIN 1 mg 258.00 0 C (UCN-1028C) 159080 [69552-46-1] Purity: 99% -20oC (6α-Carba-prostaglandin I ; From Cladosporium cladosporioides 2 Carbocyclic PGI2) Highly specific and potent protein kinase C Purity: 99% inhibitor. Crystalline Ref.: 1. Kobayashi, E., et.al., J. Antibiot., Analog of prostaglandin with similar activity. 42, 1470 (1989). 2. Lida, T., et.al., ibid., 42, C H O MW 350.5 1475 (1989). 21 34 4 C44H38O14 MW 790.6 CARBADOX 5 g 11.00 194154 [6804-07-5] 25 g 19.00 o CALYCULIN A 10 µg 89.95 0-5 C (3-[2-Quinoxalinylmethylene]carbazic acid 100 g 55.00 ′ 158378 [101932-71-2] 50 µg 335.65 methyl ester-N,N -dioxide) 0-5oC Purity: ≥95% Purity: 97% Phosphatase inhibitor with very potent C11H10N4O4 MW 262.2 inhibitory activity against both PP1 and PP2A phosphatases. CARBAMYLCHOLINE CHLORIDE 10 g 18.00 IC50 values of approximately 1 nm for both 100194 [51-83-2] 25 g 32.00 PP1 and PP2A. RT (Carbachol) 100 g 131.00 Ref.: 1. Ishihara, H., et.al., Biochem. Crystalline Biophys. Res. Commun., 159, 871 (1989). Purity: 99% 2. Suganuma, M., et.al., Cancer Res., 50, Non-selective agonist that is resistant to the 3521 (1990). action of cholinesterase. Inhibits apoptotic C50H81N4O15P MW 1009.18 death of cultured granule neurons. C6H15ClN2O2 MW 182.65

To place an order: (800) 854-0530, fax (800) 334-6999 1162 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ CARBETAPENTANE 250 mg 49.00 1-[2-(CARBOXYLATO)PYRROLIDIN-1- 1 mg 10.50 150557 [23142-01-0] 1 g 160.00 196051 YL]DIAZEN-1-IUM-1,2-DIOLATE 5 mg 27.30 0-5oC (1-Phenylcyclopentanecarboxylic acid -20oC METHANOL 25 mg 99.75 2-[2-diethylaminoethoxy]ethyl ester) (PROLI NONOate, PROLI/NO) Citrate Salt Disodium Salt High affinity agonist for sigma1 receptors. Purity: ≥98% Antitussive A nitric oxide donor. White crystalline powder Ref.: Saavedra, J.E., et al., Jour. of Med. C20H31NO3 • C6H8O7 MW 525.6 Chem., 39(22), 4361-4365 (1996). S(-)-CARBIDOPA 10 mg 16.00 C5H7N3O4Na2 MW 251.1 153757 [28860-95-9] 15 mg 20.00 RT (S(-)-α-Hydrazino-3,4-dihydroxy- 25 mg 28.00 (±)-3-CARBOXYPHENYLGLYCINE 1 mg 21.45 α-methylbenzenepropanoic acid) 100 mg 91.25 159740 [2196-57-8] 5 mg 86.00 Used as a Parkinson’s Disease therapeutic RT C9H9NO4 MW 195.2 10 mg 155.90 in combination with L-DOPA. C10H14N2O4 MW 226.2 ± 5 mg 72.80 ± µ ( )-3-(2-CARBOXYPIPERAZIN-4-YL)- (±)CARBOCYCLIC THROMBOXANE 100 g 57.35 158885 PROPYL-1-PHOSPHONIC ACID 151446 500 µg 229.30 o A2 RT [100828-16-8] 0 C [74034-56-3] (CPP) (CTA2) Purity: 98% Supplied as 50 µg/ml in ethanol. Strong NMDA antagonist. C22H36O3 MW 348.5 Ref.: Davies, J., et.al., Brain Res., 382, 169 β 1 mg 14.35 (1986) -CARBOLINE-3-CARBOXYLIC ACID C H N O P MW 252.2 159731 BUTYL ESTER 5 mg 48.70 8 17 2 5 RT [84454-35-3] Benzodiazepine receptor ligand R-(-)-3-(2-CARBOXYPIPERAZIN-4-YL)- 1 mg 29.95 C16H16N2O2 MW 268.3 196042 PROPYL-1-PHOSPHONIC ACID 5 mg 118.50 β RT [126453-07-4] -CARBOLINE-3-CARBOXYLIC ACID 25 mg 15.00 (D-CPP; R-CPP) 153715 ETHYL ESTER 250 mg 86.75 Purity: ≥98% RT [74214-62-3] β Potent and selective NMDA antagonist. ( -CCE) Ref.: Chapman, A.G., et.al., Eur. Jour. of Purity: 98% Pharmacol., 178(1), 97-99 (1990) Inverse agonist to benzodiazepine C8H17N2O5P MW 252.2 C14H12N2O2 MW 240.3 β-CARBOLINE-3-CARBOXYLIC ACID 10 mg 24.95 CARBOXY-PTIO 1 mg 11.75 154934 25 mg 99.75 o METHYL ESTER 159815 [148819-94-7] 5 mg 30.00 0-5 C [69954-48-9] 100 mg 169.50 0-5oC (2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimid 25 mg 120.00 (β-CCM) azoline-1-oxyl-3-oxide) Benzodiazepine inverse agonist Potassium Salt Ref.: Lippke, K.P., et al., J. Med. Chem., Nitric Oxide radical scavenger with 26, 499 (1983). antagonistic action against the NO free C13H10N2O2 MW 226.2 radical. β Ref.: Akaike, T., et al., Biochemistry, 32, -CARBOLINE-3-CARBOXYLIC ACID 10 mg 19.55 827 (1993). 153774 15 mg 27.35 PROPYL ESTER C14H16N2O4K MW 315.4 RT [76808-18-9] 25 mg 43.35 (β-CCP) Benzodiazepine inverse agonist CARISOPRODOL 250 mg 7.00 C15H14N2O2 MW 254.3 153548 [78-44-4] 1 g 15.00 RT (1-Methylethyl)carbamic acid N-CARBOMETHOXYCARBONYL-D- 1 mg 11.45 2-[[(aminocarbonyl)oxy]-methyl]-2- 159735 D 5 mg 28.10 o PRO- -PHE BENZYL ESTER methylpentyl ester) 0 C [129988-00-7] 25 mg 112.35 C12H24N2O4 MW 260.3 (Harvard Peptide) Blocks gp120 binding to CD4 glycoprotein. Reported to inhibit infection by HIV. α-CASEIN, Fragment 90-95 1 mg 30.30 152944 [83471-50-5] Ref.: Finberg, R. W., et al., Science, 249, o 287 (1990). -20-0 C (Arg-Tyr-Leu-Gly-Tyr-Leu) C24H26N2O6 MW 438.5 Ref: Loukas, S., et al., Biochemistry, 22, 4567 (1983). N-CARBOMETHOXYCARBONYL- 1 mg 13.75 C38H57N9O9 MW 783.9 159736 PRO-PHE BENZYL ESTER 5 mg 55.00 0oC Blocks gp120 binding to CD4 glycoprotein and inhibits HIV infection, but is less active α-CASEIN, Fragment 90-96 1 mg 35.00 152945 [83471-49-2] 5 mg 163.00 than the D-isomer peptide. o Ref.: Finberg, R.W., et al., Science, 249, -20-0 C (Arg-Tyr-Leu-Gly-Tyr-Leu-Glu) 287 (1990). C43H64N10O12 MW 912 C24H26N2O6 MW 438.5 5-CARBOXAMIDOTRYPTAMINE 1 mg 17.00 CASEIN KINASE II 10 KU 330.70 195818 EC 2.7.1.37 153756 MALEATE 5 mg 72.00 o -20-0oC [74885-09-9] -20 C Human, Recombinant Expressed in E. coli 5-HT1 serotonin receptor agonist C H N O • C H O MW 319.3 Supplied at 0.7 mg/ml in Tris/NaCl/0.1% 11 13 3 4 4 4 Triton X-100. 1-(7-CARBOXYHEPTYL)IMIDAZOLE 5 mg 34.40 Activity: 700 kU/mg protein 159564 Hydrochloride 25 mg 149.05 Unit Definition: one unit will transfer one 0-5oC Selective thromboxane synthetase inhibitor. pmol of phosphate from ATP to peptide Ref.: Kayama, et al., Prostaglandins, 21, substrate per minute at 30°C. 543 (1981) Free of proteases and phosphatases. C11H8N2O2 • HCl MW 246.7 One call. One source. 1163 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ CASEIN KINASE II 1 vial 367.20 CAVEOLIN 195946 Human, Recombinant MONOCLONAL ANTIBODY -20oC Expressed in E. coli (22kDa RSV-SRC Substrate, Anti-) α-Subunit Clone: 2283 Catalytic subunit of protein kinasae CK2. Isotype: purified Ig fraction from mouse ascites Unit Definition: one unit will catalyze the Conc/Titer: 1:1,000-1:5,000 transfer of 1 µmol of phosphate from ATP Applications: ELISA; Immunoblotting; Immunoprecipitation; to the synthetic casein kinase II substrate Immunohistology RRRDDDSDDD per minute at pH 8.5, It has been suggested that this protein is a mediator of 37°C. transformation by the tyrosine kinase class of oncogenes. For One vial contains 10 mU. this product, a monoclonal antibody (ICN PY20) was coupled to MW 45,100 agarose and used as an affinity chromatography medium to isolate phosphotyrosine-containing proteins from Rous sarcoma CASEIN KINASE II 10 µg 374.50 virus-transformed chick embryo fibroblasts. Balb/c mice were 195947 Human, Recombinant immunized with these PY20 proteins for production of antibodies -20oC Expressed in E. coli to the 22 kDa tyrosine kinase substrate. Hybridomas were β-Subunit selected for reactivity against the mixture of PY-proteins by ELISA Purity: ≥99% and against the 22 kDa protein by Western Blot. Enhances enzymatic activity and specificity The antibody is packaged at a concentration of 1 mg/ml in 50% to the α-subunit of protein kinase CK2. glycerol, 5mM Tris, pH 8.2, 25mM NaCl, 1.5 mM NaN3. It is easily Contains no detectable proteases. conjugated to enzymes and fluorochromes. MW 24,900 Ref: 1. Glenney, J.R., Jr., J. Biol. Chem., 264, 20163-20166 (1989). CASEIN KINASE II SUBSTRATE 1 mg 110.25 2. Glenney, J.R., Jr. and Zokas, L., J. Biol. Chem., 108, 2401-2408 (1989). 195842 Arg-Arg-Glu-Glu-Glu-Thr-Glu-Glu-Glu µ -20oC Purity: ≥97% 697002 50 g 380.35 A specific substrate for Casein Kinase II 697001 100 µg 650.45 (CKII). MW 1206.3

β-CASOMORPHIN 0.5 mg 17.00 150567 [72122-62-4] 1 mg 25.00 -20-0oC (Tyr-Pro-Phe-Pro-Gly-Pro-Ile) 5 mg 56.00 Source/Species: Bovine sCD14 ELISA KIT 1 each 986.75 Ref.: 1. Brantl, V., et al., Hoppe-Seyler’s Z. 193599 The sCD14 kit is a sandwich enzyme Physiol. Chem., 360, 1211 (1979). 0-5oC immunoassay for the determination of 2. Lottspeich, F., et al., Hoppe-Seyler’s Z. soluble CD14 in human serum, plasma, Physiol. Chem., 361, 1835 (1980). liquor, synovial fluid, urine, and cell culture MW 790 supernatants. An anti-CD14 oligoclonal antibody is adsorbed to polystyrene β-CASOMORPHIN 1 mg 15.00 microtiter wells. Soluble CD14 present in 154498 [102029-74-3] o the sample or the standard binds to the 0-5 C H2N-Tyr-Pro-Phe-Val- antibodies on the coated well. A biotinylated Glu-Pro-Ile-OH anti-CD14 monoclonal antibody directed Source/Species: Human against another epitope on the CD14 Ref.: Greenberg, R., et al., (1984), J. Biol. molecule is simultaneously added. After Chem. 259, 132 washing, a streptavidin peroxidase C44H61N7O11 MW 864.1 conjugate binds to the bound complex, completing the sandwich. Unbound β-CASOMORPHIN, Fragment 1-3 0.5 mg 10.00 conjugate is removed by washing, and the 150568 [72122-59-9] 1 mg 15.00 substrate solution is added to the wells. A -20-0oC (Tyr-Pro-Phe) 5 mg 25.00 colored product is formed in proportion to C23H27N3O5 MW 425.5 the amount of CD14 present in the sample. The kit is a 12 x 8 format. β-CASOMORPHIN, Fragment 1-5 0.5 mg 10.00 FOR RESEARCH USE ONLY! 150569 [72122-63-5] 1 mg 25.00 -20-0oC (Tyr-Pro-Phe-Pro-Gly) 5 mg 45.00 C30H37N5O7 MW 579.7

2 4 5 [D-Ala ,Hyp ,Tyr ]-β-CASOMORPHIN, 1 mg 33.30 152946 Fragment 1-5 Amide -20-0oC CD45 0.5 ml 285.00 [102029-98-1] 685521 MONOCLONAL ANTIBODY (Tyr-D-Ala-Phe-Hydroxy-Pro-Tyr-NH2) 0-5oC C H N O MW 674.8 Anti-Human 35 42 6 8 Clone: T200 (Also known as HuLy-m4 from 190.2F2.5) 1 β 1 mg 24.00 [Des-Tyr ]- -CASOMORPHIN Isotype: purified mouse IgG1 152949 [100900-41-2] o Conc/Titer: 0.5 mg/ml -20-0 C (Pro-Phe-Pro-Gly-Pro-Ile) Applications: Flow Cytometry; Indirect C32H46N6O7 MW 626.8 Immunofluorescence; Indirect Immunoperoxidase staining CASTANOSPERMINE 1 mg 42.00 This antibody detects the major surface 150570 [79831-76-8] 5 mg 138.00 glycoprotein analog of the murine and rat 0-5oC (1,6,7,8-tetrahydroxy- T200 molecule which is found on blood octahydroindolizine) lymphocytes, monocytes, granulocytes, null Lyophilized powder cells, platelets, thymocytes, tonsillar cells, Under desiccant and myeloid cells from bone marrow. A potent α and β-glucosidase inhibitor. Also known to cause accumulation of high mannose glycoproteins, such as concanavalin A. C8H15NO4 MW 189.2

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ CD45RO 0.1 mg 208.00 CGS 21680 1 mg 25.00 685941 MONOCLONAL ANTIBODY 193631 [124182-57-6] 5 mg 95.00 0-5oC Anti-Human -20oC Hydrochloride 10 mg 172.00 Clone: UCHL-1 Adenosine receptor agonist which exhibits Isotype: mouse IgG1 kappa higher selectivity for A2 versus A1 receptors. Conc/Titer: 1 mg/ml Ref.: Jarvis, et al., J. Pharmacol. Exp. Applications: immunohistology; Ther., 251, 888 (1989). immunofluorescence; immunoprecipitation C23H29N7O6 • HCl MW 536.0 This antibody reacts with NK cells, T cells and B cell subsets, monocytes, and macrophages. It binds an epitope strongly CHARYBDOTOXIN 100 µg 586.30 expressed on the lower molecular weight 158887 [95751-30-7] isoform (p180) of the human leukocyte -20-0oC (pGlu-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser- common antigen (LCA) family, close to the Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-H UCHL-1 epitope. This epitope is also is-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys weakly expressed on 190 kDa (exon B) and -Lys-Cys-Arg-Cys-Tyr-Ser) 205 kDa (exons AB) isoforms of LCA. This Purity: >98% antibody stains most thymocytes (about Scorpion Leiurus quinquestriatus venom 50% of medullary thymocytes) and also peptide mature myeloid cells. A potent and specific inhibitor of Ca2+ activated K+ channels in cells of the anterior pituitary and bovine aortic smooth muscle. CD45RO F(ab′′′)2 0.1 mg 298.00 Also, demonstrates inhibition of potassium 685961 MONOCLONAL ANTIBODY ion conductance and human T lymphocyte 0-5oC Anti-Human mitogen-stimulated proliferation. Clone: A6 Ref.: 1. Gimenez-Gallego, G., et.al., Proc. Isotype: mouse IgG1 kappa Natl. Acad. Sci. USA, 85, 3329 (1988). 2. Conc/Titer: 1 mg/ml Mackinnon, R. and Miller, C., Science, 245, Applications: immunohistology; 1382 (1989). 3. Deutsch, C., et.al., J. Biol. immunofluorescence; immunoprecipitation Chem., 266, 3668 (1991). 4. Price, M., This antibody reacts with NK cells, T cells et.al., Proc. Natl. Acad. Sci. USA, 86, and B cell subsets, monocytes, and 10171 (1989). macrophages. It binds an epitope strongly MW 4295.9 expressed on the lower molecular weight isoform (p180) of the human leukocyte common antigen (LCA) family, close to the [Gln12]-CHARYBDOTOXIN 100 µg 551.25 UCHL-1 epitope. This epitope is also 159567 (pGlu-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser- weakly expressed on 190 kDa (exon B) and -20-0oC Lys-Gln-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-H 205 kDa (exons AB) isoforms of LCA. is-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys -Lys-Cys-Arg-Cys-Tyr-Ser) MW 4294.2 L-CELL ADHESION MOLECULE 1 ml 215.00 692371 o MONOCLONAL ANTIBODY -20 C (Anti-L-CAM; Anti-Uvomorulin) [His19]-CHARYBDOTOXIN 100 µg 288.00 Anti-Human 159568 (pGlu-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser- Clone: 6 F9 -20-0oC Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-His-Leu-Hi Isotype: mouse IgG1 s-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys Conc/Titer: 1:5-1:20 -Lys-Cys-Arg-Cys-Tyr-Ser) Applications: ELISA; Immunoblotting; MW 4276.2 Immunostaining of cell suspensions, acetone-fixed frozen and formalin-fixed paraffin-embedded tissue sections. [Lys(Ac)11]-CHARYBDOTOXIN 100 µg 551.25 Supplied as cell supernatant purified by 159569 (pGlu-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser- ammonium sulfate precipitation with 1% -20-0oC Lys(Ac)-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Le BSA and 0.09% sodium azide. u-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn This antibody reacts to E-cadherin 2+ -Lys-Lys-Cys-Arg-Cys-Tyr-Ser) (epithelial Ca dependent cell adhesion MW 4337.2 molecule) in ELISA and show specific reaction to teh 120 kDa and 80 kDa ARC-1 polypeptides in immunoblotting. 1 mg 21.00 Ref.: Frixen, U.H., et al., J. Cell Biolog, 113, CHELERYTHRINE CHLORIDE 158888 [3895-92-9] 5 mg 68.75 173-185 (1991). o 2. Umbas, R., et al., Cancer Res., 52, 0 C (1,2-Dimethoxy-N-methyl-[1,3]-benzodioxolo[ 10 mg 131.90 5104-5109 (1992). 5,6c]phenanthridinium) 25 mg 309.60 Purity: 98% Specifically inhibits protein kinase C. CGS 12066B DIMALEATE 5 mg 36.00 Ref.: Herbert, J.M., et.al., ibid., 172, 993 158886 [109028-10-6] 20 mg 125.00 (1990). C H NO Cl MW 383.8 RT Purity: 99% 21 18 4 Specific 5-HT1B agonist. Ref.: Neale, R.F., et.al., Eur. J. Pharmacol., 136, 1 (1987). CHLORMEZANONE 250 mg 28.65 MW 566.5 159741 [80-77-3] 1 g 100.85 RT Skeletal muscle relaxant. C11H12NO3SCl MW 273.8 CGS 15943 1 mg 7.00 193630 [104615-18-1] 10 mg 41.50 RT Potent, selective A1-Adenosine receptor 2-CHLOROADENOSINE 2 mg 8.00 antagonist. 153755 [146-77-0] 5 mg 12.95 Ref.: Jarvis, et al., Mol. Pharmacol., 39, 49 RT (2-CADO) 10 mg 22.90 (1990). A selective A1 adenosine receptor agonist 50 mg 65.75 C13H8 N5OCl MW 285.7 C10H12CIN5O4 MW 301.7

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 8-CHLOROADENOSINE-cyclic-3′′′,5′′′- 5 mg 78.00 6-CHLOROMELATONIN 1 mg 19.25 152400 MONOPHOSPHATE 10 mg 128.00 159748 Inhibits calcium-dependent dopamine 5 mg 81.00 RT [41941-56-4] 25 mg 275.00 release. (8-Chloro-cAMP). 250 mg 795.00 C13H15N2O2Cl MW 266.7 An analog of c-AMP that demonstrates novel properties in cell culture, including steroidogenic activity in rat adrenal cells 1-(5-CHLORONAPHTHALENE- 1 mg 10.50 159750 SULFONYL)HOMOPIPERAZINE 5 mg 43.00 and inhibition of a variety of cancer cells in o culture. 0-5 C [105637-50-1] Ref.: 1. Free, C.A. and Paik, V.S., Hydrochloride Inhibits myosin light-chain kinase. Endocrinology, 100, 1287-1293 (1977). 2. • Tagliaferri, P., et al., Cancer Res., 48, C15H17N2O2SCl HCl MW 361.3 1642-1650 (1988). C10H11N5O6PCl MW 363.7 1-(5-CHLORONAPHTHALENE-1- 05 mg 35.00 6 158889 10 mg 51.60 2-CHLORO-N -CYCLO- 1 mg 16.55 o SULFONYL)-1H-HEXAHYDRO-1,4- 193632 PENTYLADENOSINE 5 mg 62.00 0 C DIAZEPINE 25 mg 97.45 RT [37739-05-2] 25 mg 260.00 [105637-50-1] (CCPA) (ML-9) A very selective A1 Adenosine receptor Hydrochloride agonist. Purity: 99% C15H20N5O4Cl MW 369.8 Specifically inhibits MLC kinase. Ref.: 1. Saitoh, M., et.al., J. Biol. Chem., 7-CHLORO-3-(CYCLOPROPYL- 1 mg 14.95 262, 7796 (1987). 2. Saitoh, M. et.al., 159903 CARBONYL)-4-HYDROXY-2(1H)- 5 mg 61.00 Biochem. Biophys. Res. Commun., 140, RT QUINOLINE 280 (1986). (L-701252) C15H17N2O2SCl • HCl MW 361.3 Purity: 99% Antagonist of NMDA receptor glycine site and an anticonvulsant. 1-(3-CHLOROPHENYLAMINO)-4- 1 mg 13.00 Ref.: Rowley, M., et al., J. Med. Chem., 36, 158890 PHENYLPHTHALAZINE 10 mg 107.45 3386 (1993). RT (MY 5445) MW 263.7 Purity: 99% Specifically inhibits cGMP-specific CHLOROETHYLCLONIDINE 1 mg 13.50 phosphodiesterase. 153753 [98086-36-3] 10 mg 105.00 Ref.: Hagiwara, M., et.al., J. Pharmacol. 0-5oC Dihydrochloride 25 mg 238.00 Exp. Ther., 228, 467 (1984). C13H17Cl3N4 • 2HCl MW 408.6 MW 331.8 N-(2-CHLOROETHYL)-N-ETHYL-2- 5 mg 10.00 154966 BROMOBENZYLAMINE 25 mg 37.00 1-(3-CHLOROPHENYL)BIGUANIDE 5 mg 13.00 RT [40616-75-9] 100 mg 142.80 159751 [2113-05-5] 25 mg 31.00 (DSP-4) RT Hydrochloride 100 mg 98.00 Hydrochloride Specific agonist for 5-HT3 receptor. α-adrenergic agent Ref.: Sepulveda, et al., Br. J. Pharmacol., Ref.: Dooley, D.J., et al., 6th European 104, 536 (1991). Neuroscience Congress (1982). C8H10N5Cl • HCl MW 248.1 C11H15BrClN • HCl MW 313.1 R(-)-CHLOROETHYL- 1 mg 10.00 4-CHLOROPHENYLGUANIDINE 5 mg 11.45 153754 NORAPOMORPHINE 10 mg 89.30 159752 Hydrochloride 25 mg 52.00 0-5oC RT Specific inhibitor of Urokinase. 100 mg 186.75 [75344-87-5] • (NCA) C7H8N3Cl HCl MW 206.1 Hydrochloride Dopamine receptor alkylating agent. • 5-CHLORO-N-(6-PHENYLHEXYL)-1- 1 mg 16.50 C18H18CINO2 HCl MW 352.3 159753 5 mg 72.00 o NAPHTHALENESULFONAMIDE 7-(β-CHLOROETHYL)- 100 mg 21.75 0-5 C [102649-78-5] 153546 THEOPHYLLINE 1 g 36.15 (SC-9) RT [5878-61-5] Potent Protein Kinase C activator which (1,3-Dimethyl-7-(β-chloroethyl)xanthine) apparently substitutes for phosphatidylserine. C9H11CIN4O2 MW 242.6 C22H24NO2SCl MW 401.9 5-CHLOROINDOLE-2-CARBOXYLIC 1 g 34.50 159746 ACID 5 g 124.25 0-5oC [10517-21-2] 1-(2-CHLOROPHENYL)-N-METHYL-N- 1 mg 10.50 Antagonist of NMDA receptor at the glycine 196050 (1-METHYLPROPYL)-3- 5 mg 33.60 site. RT ISOQUINOLINECARBOXAMIDE 25 mg 115.50 Ref.: Huettner, Science, 243, 1611 (1989). [85532-75-8] C9H6NCl MW 195.6 (PK-11195) Purity: ≥98% 1-(8-CHLORO-5-ISOQUINOLINE- 10 mg 76.50 Benzodiazepine antagonist. 154176 SULFONYL)PIPERAZINE Ref.: Le Fur, G., et al., Life Science, 32(16), -20-0oC (HA-156) 1849-1856 (1983). Crystalline C21H21ClN2O MW 352.9 Purity: >97% A Protein Kinase C inhibitor. 1-(m-CHLOROPHENYL) 1 g 12.45 7-CHLOROKYNURENIC ACID 1 mg 8.00 150651 PIPERAZINE 5 g 27.00 153752 [18000-24-3] 10 mg 49.00 RT [65369-76-8] RT (7-Chloro-4-hydroxyquinoline-2-carboxylic 25 mg 105.00 Hydrochloride acid) Purity: ∼97% NMDA receptor antagonist at the glycine 5-HT1 serotonin receptor agonist site. C10H13ClN2 • HCl MW 233.1 C10H6CINO3 MW 223.6

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 8-(4-CHLOROPHENYLTHIO)- 10 mg 23.50 CHOLERA ENTEROTOXIN 1 mg 85.00 158891 ′′′ ′′′ 50 mg 79.50 190329 Lyophilized powder sealed under vacuum 5 mg 380.00 o ADENOSINE-3 ,5 -cyclic- o -20-0 C MONOPHOSPHATE 100 mg 147.00 0 C Each vial when reconstituted to 1ml with [93882-12-3] H2O contains 1.0 mg (or 5.0 mg) of protein, (8-CPT cAMP) at pH 7.5 suspended in 0.05 M Tris 0.003M Sodium Salt NaN3 0.001M Na2EDTA, 0.2M NaCl cAMP analog which activates cAMP- and Concentration: Determined by extinction at cGMP- dependent protein kinase. 280 nm. Ref.: Sandberg, M., et.al., Biochem. J., Purity: Preparation gives a single major 279, 521 (1991). band in discelectrophoresis. C16H14ClN5O6PSNa MW 493.8 Toxic Potency: Determined by skin vascular permeability and expressed in Lb doses per µg Lowry protein Ref.: 1. Finkelstein, R.A., et al., J. 8-(3-CHLOROSTYRYL)CAFFEINE 1 mg 10.00 Immunol., 113, 145 (1974) 193634 (1,3,7-Trimethyl-8-(3-chlorostyryl)xanthine) 5 mg 38.60 2. Finkelstein, R.A., CRC Crit. Rev. o Microbiol, 2, 553 (1973) -20 C Selective A2a adenosine receptor antagonist. 25 mg 163.15 Ref.: Jacobson, et al., J. Med. Chem., 36, 3. Finkelstein, R.A. and Lo Spalluto, J. Exp. 1333 (1993). Med., 130, 185 (1969) C H N O Cl MW 330.8 4. Hollenberg, M.D., et al., Proc. Nat. Acad. 16 15 4 2 Sci. U.S.A., 71, 4224 (1974)

1 mg 90.50 40 µg 319.70 CHOLERA TOXIN CHLOROTOXIN 150005 From V. cholerae 569B Inaba 193947 From Leiurus q. quinquestriatus o -20oC The first polypeptide toxin reported to probe 0 C Purity: >95% by SDS-PAGE chloride ion channels. It inhibits Lyophilized in Tris-EDTA buffer, pH 7.5 submicromolar concentration small Activator of adenylate cyclase conductance chloride ion channels intracellularly. µ 195.00 Ref.: DeBin, et al., Am. J. Physiol., 264, CHOLERA TOXIN 250 g 159905 From Vibrio cholerae C361 (1993). o α MW 3996 0-5 C -Subunit Lyophilized Possesses ADP-ribosyltransferase activity. As effective as native toxin, it catalyzes ADP-ribosylation in broken cell 4-CHLORO-6-(2,3-XYLIDINO)-2- 10 mg 23.40 preparations. However, without the 159904 PYRIMIDINYLTHIOACETIC ACID 50 mg 105.00 presence of the B-subunit, it is not able to RT [50892-23-4] penetrate cells. (WY-14643) Ref.: Gill, D.M. and Woolkalis, M.J., Purity: 98% Methods Enzymol., 195, 267 (1991). Potent activator of peroxisome proliferator-activated receptors (PPARs). Ref.: 1. Keller, H. and Wahli, W., Trends CHROMOMYCIN A3 1 mg 16.75 Endocrinol. Metab., 4, 291 (1993). 150686 [7059-24-7] 5 mg 65.20 2. Dreyer, C., et al., Cell, 68, 879 (1992). 0oC (3β-O-(4-O-Acetyl-2,6-dideoxy-3-C- MW 323.8 methyl-α-L-arabino hexopyranosyl)- 7-methylolivomycin D; Aburamycin β; Toyomycin) Yellow powder CHLORPHENESIN CARBAMATE 1 g 18.50 m.p. 185-186°C 150662 [886-74-8] Inhibitor of DNA and RNA polymerases. RT (3-[4-Chlorophenoxy]-1,2-propanediol-1-carb C57H82O26 MW 1183.3 amate) m.p. 88-91°C White crystalline powder CHYMOSTATIN 1 mg 15.00 An antifungal agent and a smooth muscle 152845 [9076-44-2] 5 mg 45.00 relaxant. -20-0oC ([(S)-1-Carboxy-2-phenylethyl]-carbamoyl-α- 25 mg 195.00 [2-iminohexahydro-4(S)-pyrimidyl]-(S)-Gly-X- 50 mg 375.00 Phe-al) Source/Species: Microbial CHLORPHENIRAMINE MALEATE 5 g 10.75 A mixture of type A, B, and C. 190325 [113-92-8] 25 g 29.00 X = Leu (Type A); Ile (Type B); Val (Type C). RT Antihistaminic 100 g 67.00 Ref: 1. Umezawa, H., et al., J. Antibiot., 23, C20H23ClN2O4 MW 390.9 425 (1970). 2. Tatsuta, K., et al., J. Antibiot., 26, 625 (1973). CHLORPROMAZINE 5 g 11.95 190326 [69-09-0] 25 g 31.00 CILOSTAMIDE 1 mg 16.75 RT (2-Chloro-10-[3-dimethylamino-propyl] 100 g 82.50 193635 (N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo 5 mg 74.95 phenothiazine) RT -6-quinolyloxy)butyramide) Hydrochloride Inhibitor of cGMP-inhibited Reported to be useful as a substitute for phosphodiesterase. benzidine, o-dianisidine and o-tolidine in the C20H26N2O3 MW 342.2 determination of microquantities of hemoglobin and peroxidase. Ref.: Lee, K.T. and Ling, H., Microchim. CIMETEROL 1 mg 13.75 Acta. 995 (1969). 159757 [54239-37-1] 5 mg 53.90 C17H19ClN2S • HCl MW 355.3 RT A β-adrenergic agonist. 25 mg 225.00 C12H17N3O MW 219.3

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ CIMETIDINE 1 g 9.65 CLONIDINE 100 mg 21.50 150687 [51481-61-9] 5 g 23.00 190175 [4205-90-7] 250 mg 49.50 0-5oC Crystalline 10 g 38.00 0-5oC Hydrochloride 1 g 165.00 Histamine H2-receptor antagonist that 25 g 74.40 (2-(2,6-Dichloroaniline)-2-imidazoline) 5 g 469.00 inhibits gastric acid secretion and reduces Antihypertensive, α2-adrenoceptor agonist pepsin production. Also a potent and imidazoline receptor ligand. imidazoline I1 receptor agonist. C9H9Cl2N3 • HCl MW 266.6 Ref.: Brimblecombe, R.W., et al., J. Int. Med. Res., 3, 86 (1975). CLOPROSTENOL 1 mg 83.25 C10H16N6S MW 252.3 159084 [54276-21-0] CINANSERIN 1 mg 12.50 -20oC (16-(m-chlorophenoxy)-tetranor-prostaglandin 159758 [1166-34-3] 5 mg 48.00 F2α sodium salt) 0-5oC A 5-HT antagonist. 25 mg 215.50 Sodium Salt C20H24N2OS MW 340.5 Purity: 98% More potent than fluprostenol. CINNAMYL-3,4-DIHYDROXY-α- 10 mg 68.75 Ref.: Dukes, M., et.al., Nature, 250, 330 159083 CYANOCINNAMATE (1974). RT (CDC) C22H28O6ClNa MW 446.9 Purity: 98% Specifically inhibits 12-lipoxygenase. CLORGYLINE 25 mg 26.10 Ref.: Cho, H., et.al., J. Med. Chem., 34, 153750 [17780-72-2] 50 mg 47.70 1505 (1991). RT (N-Methyl-N-propargyl-3-(2,4-dichlorophenox 100 mg 86.75 MW 321.3 y)-propylamine) CIRAZOLINE 1 mg 11.50 Hydrochloride 193637 [40600-13-3] 5 mg 46.30 Monoamine Oxidase-A inhibitor. • RT Hydrochloride C13H15Cl2NO HCl MW 308.6 A selective α1-adrenergic receptor agonist. C13H16N2O • HCl MW 252.7 CLOZAPINE 5 mg 7.00 159760 10 mg 12.25 5 g 17.50 [5786-21-0] L-CITRULLINE RT Potent, selective muscarinic antagonist. 50 mg 49.00 101397 25 g 47.00 [372-75-8] Also exhibits the highest reported affinity for 250 mg 215.00 RT (L-2-Amino-5-ureidovaleric acid) 100 g 144.00 5-HT1A and 5-HT1C sites. Crystalline 500 g 550.00 Ref.: Mason and Reynolds, Eur. J. C6H13N3O3 MW 175.2 1 kg 950.00 Pharmacol., 221, 397 (1992). CLENBUTEROL 5 mg 8.00 C18H19N4Cl MW 326.8 159759 [37148-27-9] 10 mg 12.50 3 RT A β2-agonist and bronchodilator. 50 mg 42.00 CLOZAPINE, [N-Methyl- H] 25µCi 204.95 C12H18N2OCl2 MW 277.2 250 mg 145.00 26028 Sp. Act. 10-20 Ci/mmol 250µCi 908.35 o 0-5 C 370-740 GBq/mmol 4x250µCi 2060.45 CLINDAMYCIN 10 mg 28.35 Ethanol under nitrogen 191168 [21462-39-5] 50 mg 92.45 o Shipped in dry ice. 0-5 C (7[S]-Chloro-7-deoxylincomycin; Cleocin) 100 mg 167.00 Please call for delivery information. Hydrochloride MW 326.45 C18H33ClN2O5S • HCl MW 461.4 CLINDAMYCIN PHOSPHATE 10 mg 21.50 COCHLIOBOLIN A 158892 [24729-96-2] 50 mg 75.00 0-5oC (Clindamycin-2-dihydrogen phosphate; 100 mg 133.00 See: Ophiobolin A 7(S)-Chloro-7-deoxylincomycin; Antibiotic U-28508E) C18H34N2O8PSCl MW 505 COLCEMID CLOBENPROPIT 1 mg 35.90 See: Demecolcine 193638 [145231-45-4] o 0-5 C (VUF 9153; COLCHICINE 100 mg 9.95 N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)prop 101406 [64-86-8] 500 mg 28.50 yl]isothiourea) RT Special Shipping Requirements: Hazardous 1 g 47.50 Dihydrobromide Material. Contact Customer Service for 5 g 191.00 A specific H3 histamine receptor antagonist details. $8.00 additional service charge per capable of crossing the blood brain barrier. shipment. Ref.: Schlicker, et al., Fundam. Clin. C H NO MW 399.4 Pharmacol., 8, 128 (1994). 22 25 6 C14H17N4SCl • 2HBr MW 470.7 COMPOUND 5 CLOFIBRATE 250 mg 9.25 190342 [637-07-0] 1 g 22.00 See: HDBA RT [2-(p-Chlorophenoxy)-2-methylpropionic 5 g 73.00 acid ethyl ester] 10 g 124.00 C H ClO MW 242.7 COMPOUND 48/80 50 mg 16.75 12 15 3 159026 [94724-12-6] 100 mg 27.50 CLOFILIUM TOSYLATE 15 mg 17.50 0oC Oligomeric mixture of condensation 153749 [92953-10-1] 25 mg 26.50 products from 0-5oC (4-Chloro-N,N-diethyl-N-heptylbenzenebutan 50 mg 46.50 N-methyl-p-methoxyphenethylamine and aminium tosylate) formaldehyde. Protein G activator similar to C28H44CINO3S MW 510.15 mastoparan. Calmodulin and platelet PLC inhibitor. Also acts as a histamine releaser. CLOMIPRAMINE 25 mg 6.00 Ref.: 1. Mousli, M., et.al., FEBS Lett., 259, 153751 [17321-77-6] 250 mg 12.75 260 (1990). 2. Gietzen, K., et.al., Biochim. RT (3-Chloro-10,11-dihydro-N,N-di- Biophys. Acta., 736, 109, (1983). 3. methyl-5H-dibenz[b,f]azepine-5-propanamine Gietzen, K., Biochem. J., 216, 611 (1983). hydrochloride; Anafranil) 4. Bronner, C., et.al., Biochim. Biophys. Hydrochloride Acta., 920, 301 (1987). A serotonin uptake inhibitor. MW 630 C19H23CIN2 • HCl MW 351.3

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ CONDURITOL B EPOXIDE 5 mg 45.90 N6-CYCLOPENTYLADENOSINE 25 mg 27.50 158893 [6090-95-5] 25 mg 183.45 153744 [41552-82-3] 100 mg 75.00 o o 0 C (DL-1,2-Anhydro-myo-inositol) 0-5 C A1 adenosine receptor agonist 250 mg 151.00 Purity: 97% C15H21N5O4 MW 335.4 A potent, irreversible inhibitor of plant β-glucosidases and mammalian 8-CYCLOPENTYL-1,3- 25 mg 36.15 glucocerebrosidases. 153746 DIMETHYLXANTHINE 100 mg 122.00 Ref.: 1. Legler, G., Hoppe-Seyler’s Z. RT [35873-49-5] Physiol. Chem., 351, 25 (1970). 2. Datta, (8-Cyclopentyltheophylline) S.C. and Radin, N.S., Biochem. Biophys. A1 adenosine receptor antagonist Res. Commun., 152, 155 (1988). C12H16N4O2 MW 248.3 C6H10O5 MW 162.1 8-CYCLOPENTYL-1,3- 250 µCi 532.40 (±)-CPP 26029 DIPROPYLXANTHINE, 1 mCi 1150.90 o 3 See: (±)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid 0-5 C [Dipropyl-2,3- H] (CPX) CROTON OIL 10 g 17.95 Sp. Act. 80-120 Ci/mmol 159577 [8001-28-3] 25 g 39.00 2.96-4.44 TBq/mmol RT (Tiglium Oil) 100 g 130.00 Ethanol solution. d= 0.94g/ml Shipped with Dry Ice. POSSIBLE CARCINOGEN! Please call for delivery information. MW 304.0 CV-6209 1 mg 86.00 159909 [117064-08-1] o 8-CYCLOPENTYL-1,3- 25 mg 39.50 -20 C Purity: 97% 153745 DIPROPYLXANTHINE 50 mg 69.00 Competitive antagonist to the PAF receptor. RT [102146-07-6] 100 mg 128.00 Inhibits platelet aggregation, hypotension, (DPCPX, and lethality induced by PAF. 1,3-Dipropyl-8-cyclopentylxanthine) Ref.: Terashita, Z., et al., J. Pharmacol. A1 adenosine receptor antagonist Exp. Ther., 242, 263 (1987). C H N O MW 305.4 MW 642.3 16 24 4 2 α-CYANO-3-HYDROXY- 1 g 12.50 CYCLOPIAZONIC ACID 5 mg 44.00 158895 [18172-33-3] 10 mg 79.75 150738 CINNAMIC ACID 5 g 44.75 o 0-5oC [54673-07-3] 0 C From Penicillium cyclopium 50 mg 265.00 Purity: 99% Purity: 98% Intracellular Ca2+ release inducer. Inhibits Inhibitor of mitochondrial pyruvate transport. 2+ Ref.: Halestrap, A.P., Biochem. J., 148, 85 endoplasmic reticulum Ca -ATPase. Highly selective for sarcoplasmic reticulum (1975). 2+ C10H7NO3 MW 189.2 Ca -ATPase. Ref.: Demaurex, N., et.al., J. Biol. Chem., 6-CYANO-7-NITROQUINOXALINE- 1 mg 11.50 267, 2318 (1992). 2. Goeger, D.E., et.al., 159761 2,3-DIONE 5 mg 48.50 Biochem. Pharmacol., 37, 978 (1988). 3. RT [115066-14-3] 10 mg 85.00 Seidler, N.W., et.al., J. Biol. Chem., 264, (CNQX) 17816 (1989). Purity: ≥98% C20H20N2O3 MW 336.4 Potent, competitive and selective kainate/quisqualate (non-NMDA) receptor 5′′′-(N-CYCLOPROPYL)- 10 mg 38.35 antagonist. 153743 CARBOXAMIDOADENOSINE 15 mg 54.70 C9H4N4O4 MW 232.2 RT [50908-62-8] 25 mg 86.75 (+)-CYCLOAZOCINE 1 mg 16.55 Powerful A2 adenosine receptor agonist 193641 [3572-80-3] 5 mg 49.60 C13H16N6O4 MW 320.3 o 0-5 C A sigma receptor antagonist which exhibits 10 mg 11.00 action on norepinephrine uptake. L-CYCLOSERINE 190316 [339-72-0] 25 mg 20.25 Ref.: Russi, J. Pharm. Sci., 74, 97 (1985). o C H NO MW 271.4 0 C (L-4-Amino-3-Isoxazolidinone) 18 25 Crystalline N6-CYCLOHEXYLADENOSINE 10 mg 19.85 Antibiotic substance 153748 [36396-99-3] 50 mg 86.75 Inhibitor of transaminases RT (CHA) C3H6N2O2 MW 102.1 C16H23N5O4 MW 349.4 CYCLOTHIAZIDE 1 mg 8.50 1,6-bis-(CYCLOHEXYLOXIMINO- 10 mg 74.55 159762 [2259-96-3] 5 mg 23.00 159011 CARBONYLAMINO)-HEXANE 0-5oC Strongly inhibits rapid glutamate receptor 10 mg 41.00 RT (RHC-80267) desensitization. Purity: 98% Ref.: Yamada and Tang, J. Neurosci., 13, Specifically blocks diacylglycerol (DAG) 3904 (1993). lipase activity in various cell lines of multiple C14H16N3O4S2Cl MW 389.4 species. Ref.: 1. Balsinde, J., et.al., J. Biol. Chem., CYPERMETHRIN 1 mg 8.75 266, 15638 (1991). 2. Southerland, C.A. 158896 [52315-07-8] 10 mg 53.90 and Amin, D., et.al., ibid., 257, 14006 0-5oC Mixture of 8 isomers (1982). 3. Lindlisbacher, B., et.al., J. Cypermethrin is a Type II pyrethrin and a Neurochem., 54, 1247 (1990). 4. Natarajan, potent inhibitor of calcineurin (protein R., et.al., Biochem. Biophys. Res. phosphatase 2B). Commun., 156, 171 (1988). C22H19Cl2NO3 MW 416.3 MW 394.6 2-CYCLOOCTYL-2- 1 mg 7.50 CYPRODIME 1 mg 93.50 153747 HYDROXYETHYLAMINE 5 mg 21.00 193642 [118111-51-6] RT [57559-31-6] RT ((-)-N-(Cyclopropylmethyl)-4,14-dimethoxymo Hydrochloride rphinan-6-one) Hydrobromide Phenylethanolamine N-methyltransferase µ inhibitor A -opioid receptor antagonist. C22H29NO3 • HBr MW 436.4 C10H21NO • HCl MW 207.8 One call. One source. 1169 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ CYPROHEPTADINE 25 mg 7.50 190170 [41354-29-4] 100 mg 18.15 -D- RT Hydrochloride 250 mg 45.25 DAIDZEIN 20 mg 32.95 Crystalline 158812 [486-66-8] 100 mg 109.00 Serotonin antagonist, antihistaminic and RT (4′,7-Dihydroxyisoflavone) possibly a calcium channel blocker. Purity: >98% 1 C21H21N • HCl MW 323.9 (ANHYDRATE) A negative control for ICN Genistein (tyrosine kinase inhibitor, Cat. No. 152355). L-CYSTEINE 5 g 5.50 Ref: 1. Akiyama, T., et al., (1987), J. Biol. 101444 [52-90-4] 25 g 9.85 Chem., 262, 5592. RT (β-Mercapto-L-alanine) 100 g 30.00 MW 254.2 Free Base 500 g 123.00 Crystalline 4-DAMP C3H7NO2S MW 121.2 See: 4-Diphenylacetoxy-N-methylpiperidine methiodide L-CYSTEINE 25 g 9.95 101446 [52-89-1] 100 g 27.75 DANAZOL 100 mg 27.30 RT Hydrochloride 500 g 97.00 151463 [17230-88-5] 250 mg 58.10 Monohydrate 1 kg 165.00 RT (17β-Hydroxy-2,4,17α-pregnadien-20-yno[2, 1 g 195.00 Crystalline 5 kg 675.00 3-d]-isoxazole) C3H7NO2S • HCl • H2O MW 175.6 C22H27NO2 MW 337.5 L-CYSTEINE 25 g 14.00 4-DANSYLAMINOPHENYLMERCURIC 1 mg 13.75 194646 [52-90-4] 100 g 43.00 159763 5 mg 42.40 o ACETATE RT (β-Mercapto-L-alanine) 500 g 171.00 0-5 C [53282-60-3] Free Base 1 kg 319.00 (Maddocks’ Reagent) Cell Culture Reagent Very sensitive reagent for fluorometric Crystalline determination of thiol groups. C3H7NO2S MW 121.2 Ref.: Maddocks and MacLachlan, The Lancet, 338, 1043 (1991). L-CYSTEINE 25 g 15.00 C H N O SHg MW 585.0 194647 [52-89-1] 100 g 40.80 20 20 2 4 RT Cell Culture Reagent 500 g 142.20 DANTROLENE 25 mg 10.25 Monohydrate 157521 [14663-23-1] 100 mg 36.50 Hydrochloride RT (1-[(5-[p-Nitrophenyl]- 250 mg 78.00 C3H7NO2S • HCl • H2O MW 175.6 furfurylidene)amino]hydantoin) ′′′ Sodium Salt CYTIDINE-5 -DIPHOSPHOCHOLINE 10 mg 7.75 Inhibits intracellular calcium release 101297 [33818-15-4] 50 mg 22.00 C H N O Na MW 336.2 0oC (CDP-Choline; Citicoline) 100 mg 31.50 14 9 4 5 From Yeast 500 mg 99.00 7β-DEACETYL-7β-(γ-N-METHYLPIPERAZINO)BUTYRYL Monosodium Salt 1 g 167.00 White crystalline powder. FORSKOLIN β β γ CYTIDINE-5′′′-DIPHOSPHOCHOLINE 10 mg 12.00 See: Forskolin, 7 -deacetyl-7 -( -N-methylpiperazino)butyryl 150759 (CDP-Choline) 25 mg 23.05 o DEBRISOQUIN SULFATE 10 mg 9.50 0 C Free Acid 50 mg 43.25 154278 White solid 50 mg 30.95 White crystalline powder 0oC mp 273-275°C (dec) CDP-Choline is an essential coenzyme in Soluble in water: 2.9 g/100ml the biosynthesis of lecithin. This is a highly Purity: 99% purified preparation of CDP-Choline but is C H N • 1/2H SO MW 224.3 less stable than the monosodium salt. 10 13 3 2 4 C14H26N4O11P2 MW 488.3 DECOYININE 1 mg 14.95 1 mg 48.00 159025 (U 7984) 10 mg 126.10 CYTOCHALASIN A o Purity: 99% 150769 [14110-64-6] 0 C 25 mg 225.00 o An adenine-ketose antibiotic which 0 C From Helminthosporium dematioideum specifically blocks GMP synthase. It Crystalline decreases intracellular GTP levels. Cytochalasins are fungal metabolites which Ref.: 1. Suhadolnick, R.J., Nucleoside exhibit interesting effects on cell activity. antibiotics, 96-121 (1970). 2. Glazebrook, Important tools for cytological research. M.A., J. Gen. Microbiol., 136, 581 (1990). 3. C29H35NO5 MW 477.6 Fouet, A. and Sonenshein, A.L., J. CYTOCHALASIN B 1 mg 21.50 Bacteriol., 172, 835 (1990). 195119 [14930-96-2] 5 mg 84.00 MW 279.2 o 0 C From Drechslera dematidea 10 mg 150.00 1 mg 33.95 Crystalline 6-(N-DECYLAMINO)-4- 159578 HYDROXYMETHYLINDOLE Interesting tool for cytological research. o C H NO MW 479.6 0 C [123597-55-7] 29 37 5 (DHI) CYTOCHALASIN C 1 mg 56.50 Purity: 99% 150770 [22144-76-9] Synthetic protein kinase C activator o 0 C From Metarrhizium anisopliae C19H30N2O MW 302.5 Crystalline 10 µg 49.75 C30H37NO6 MW 507.6 5,6-DEHYDROARACHIDONIC ACID 154279 [58688-54-3] 50 µg 195.00 o CYTOCHALASIN D 1 mg 54.00 -20 C Purity: 95% 100 µg 350.00 150771 [22144-77-0] 5 mg 192.00 Solution in ethanol 0oC From Zygosporium mansonii Selective, irreversible inhibitor of Crystalline 5-lipoxygenase. C30H37NO6 MW 507.6 C20H30O2 MW 302.5 CYTOCHALASIN E 1 mg 46.75 9,21-DEHYDRORYANODINE 1 mg 88.90 150772 [36011-19-5] 5 mg 154.00 159662 [94513-55-0] 0oC From Aspergillus clavatus RT From Ryania speciosa Crystalline Purity: 96% C28H33NO7 MW 495.6 C25H33NO9 MW 491.5

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ DELTAMETHRIN 1 mg 10.00 12-DEOXYPHORBOL 13-ANGELATE 1 mg 86.00 158898 [52918-63-5] 10 mg 77.10 159580 [28152-96-7] 0-5oC (Decamethrin; 25 mg 183.75 0oC Purity: 99% (S)-α-cyano-3-phenoxybenzyl-(1R)-cis-3-(2,2 POSSIBLE CARCINOGEN -dibromvinyl)-2,2-dimethylcyclopropancarbox C25H34O6 MW 430.6 ylate) This is a Type II pyrethrin and a potent 12-DEOXYPHORBOL 13-ANGELATE 1 mg 86.00 inhibitor of calcineurin (protein phosphatase 159581 20-ACETATE 2B). 0oC [25090-72-6] C22H19Br2NO3 MW 505.2 Purity: 99% Weak tumor promoter (mouse skin), but DEMECOLCINE 1 mg 19.90 moderately strong irritant 190195 [477-30-5] 5 mg 48.50 o POSSIBLE CARCINOGEN 0-5 C (N-Deacetyl-N-Methylcolchicine) 10 mg 86.50 C27H36O7 MW 472.6 Crystalline 50 mg 340.00 Used to immobilize chromosomes by 12-DEOXYPHORBOL 13- 1 mg 86.00 inactivating the spindle fiber mechanism 159583 ISOBUTYRATE 20-ACETATE during metaphase. Binds tubulin and 0oC [25090-71-5] interferes with microtubule-dependent cell Purity: 99% functions. Very weak tumor promoter (mouse skin), Ref.: Ray, K., et al., Eur. J. Biochem., 142, but moderately strong irritant. 577 (1984). POSSIBLE CARCINOGEN C21H25NO5 MW 371.4 C26H37O7 MW 460.6 DENDROTOXIN 100 µg 145.00 158899 [74811-93-1] 12-DEOXYPHORBOL 20- 1 mg 66.00 o 159584 METHOXYTRITYL ETHER -20-0 C From Dendroaspis angusticeps o Inhibits several outward voltage dependent 0 C [123597-60-4] K+ channels, specifically the transient Purity: 96% min. outward current (A current). Intermediate for synthesis of Ref.: 1. Holliwell, J.V., et.al., Proc. Natl. 12-deoxyphorbol derivatives. Acad. Sci. USA, 83, 493 (1986). 2. Dolly, POSSIBLE CARCINOGEN J.O., Trends Neurosci., 11, 186 (1988). 3. C40H44O6 MW 620.8 Castle, N.A., et.al., ibid., 12, 59 (1989). 4. Scott, V.E.S., et.al., J. Biol. Chem., 265, 12-DEOXYPHORBOL 13- 1 mg 66.00 20094 (1990). 159585 PHENYLACETATE 0oC [58821-98-0] DENDROTOXIN I 140 µg 175.00 Purity: 99% 193942 From Dendroaspis p. polylepis POSSIBLE CARCINOGEN o -20 C The most potent of all Dendrotoxins. C23H34O6 MW 466.6 Ref.: Benoit, et al., Brain Res., 377, 374 (1986). 12-DEOXYPHORBOL 13- 1 mg 86.00 MW 6936 158902 PHENYLACETATE 20-ACETATE -20-0oC [54662-30-5] β-DENDROTOXIN 35 µg 189.25 (dPPA) 193939 From Dendroaspis angusticeps Purity: 99% -20oC Selectively inhibits non-inactivated, β + Specifically activates PKC . More potent voltage-gated, α-dendrotoxin-insensitive K for the β isozyme than for the α, γ, δ, or ε. channels found in rat brain synaptosomes + Ref.: Evans, F.J., et.al., Biochem. Soc. and voltage dependent delayed rectifier, K Trans., 19, 397 (1991). current in vascular smooth muscle cells. MW 508.6 Ref.: Benishin, et al., Mol. Pharmacol., 34, 152 (1988). D-(+)-DEPRENYL 10 mg 26.00 MW 7000 151469 (N,α-dimethyl-N-2 50 mg 106.15 0oC propynyl-benzeneethanamine) (+)-1-DEOXYMANNOJIRIMYCIN 1 mg 24.00 Hydrochloride 150802 [84444-90-6] 5 mg 80.00 Inactive enantiomer RT (1,5-Dideoxy-1,5-imino-D-mannitol) 10 mg 146.00 MW 223.8 Hydrochloride Inhibits processing of N-linked glycoproteins by inhibiting the action of R-(-)-DEPRENYL 100 mg 20.75 mannosidases 1A/B. 158903 [14611-52-0] 250 mg 46.50 Ref.: Bischoff, J., et.al., J. Biol. Chem., 261, RT Hydrochloride 500 mg 80.75 4766 (1986). Purity: 98% C H NO • HCl MW 199.6 MAO-B inhibitor. Therapeutic agent for 6 13 4 Parkinson’s Disease. (+)-1-DEOXYNOJIRIMYCIN 1 mg 23.00 Ref.: 1. Tetrud, J.W. and Langston, J.W., 150819 [19130-96-2] 5 mg 76.00 Science, 245, 519 (1989). 2. Lewin, R., o Science, 230, 527 (1985). 0-5 C (1,5-Dideoxy-1,5-imino-D-glucitol) 10 mg 135.00 Hydrochloride MW 223.75 Interferes with normal processing of N-linked glycoproteins, producing reduced DEQUALINIUM CHLORIDE 1 g 13.80 amounts of complex type oligosaccharides. 157562 [522-51-0] 5 g 44.75 Ref.: J. Biol. Chem., 257, 14155 (1982). RT Crystalline C6H13NO4 • HCl MW 199.7 C30H40N4Cl2 MW 527.6 12-DEOXYPHORBOL 13-ACETATE 1 mg 86.00 DESIPRAMINE 250 mg 9.75 159579 [60857-08-1] 153543 [58-28-6] 1 g 25.00 0oC (Prostratin) RT (10,11-Dihydro-N-methyl-5H-dibenz-[b,f]azep Isolated from strathmore weed ine hydrochloride) Weak mouse ear irritant Hydrochloride POSSIBLE CARCINOGEN A norepinephrine uptake inhibitor. C22H30O6 MW 390.5 C18H23CIN2 MW 302.8

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ DESPROPIONYLFENTANYL 1 mg 67.00 DIACYLGLYCEROL KINASE 1 mg 19.95 158904 Purity: 99% 5 mg 295.00 154284 INHIBITOR II 5 mg 68.25 RT Urinary metabolite of fentanyl. 0-5oC [120166-69-0] Ref.: Van Rooy, H., et.al., J. (R59949; 3-[2-[4-[bis(4-fluorophenyl) Chromatography, 223, 85 (1981). methylene]-1-piperidinyl]ethyl]- MW 280.4 2,3-dihydro-2-thioxo-4(1H)-quinazolinone) Purity: 99% DESPROPIONYL-3- 1 mg 86.00 Inhibitor of human platelet DAG kinase. 158905 METHYLFENTANYL More potent than R 59022. RT Purity: 99% C28H25F2N3OS MW 489.6 Urinary metabolite of 3-methylfentanyl. Ref.: Hammargren, W.R. and Henderson, 2,4-DIAMINO-6-HYDROXYPYRIMIDINE 1 g 5.50 G.L., J. Anal. Toxicol., 12, 183 (1988). 150835 [56-06-4] 5 g 14.50 MW 294.4 0oC Crystalline 25 g 28.50 Purity: ∼98% DEXAMETHASONE 25 mg 10.95 A selective inhibitor of GTP cyclohydrolase 190040 [50-02-2] 100 mg 25.00 I, and a suppressor of nitric oxide synthase. 0-5oC (9α-Fluoro-16α-methylprednisolone) 500 mg 74.50 C4H6N4O MW 126.1 Crystalline 1 g 110.00 C22H29FO5 MW 392.5 5 g 395.00 2,3-DIAMINONAPHTHALENE 250 mg 23.00 150839 [771-97-1] 1 g 72.00 DEXAMETHASONE 1 mg 19.85 RT 2,3-Naphthalenediamine) 5 g 246.00 194560 [50-02-2] Used for determination of selenium. Also o used for the detection of nitric oxide via a 0-5 C (9α-Fluoro-16α-methylprednisolone) - Cell Culture Reagent sensitive fluorometric assay of nitrite (NO2 ). γ-Irradiated C10H10N2 MW 158.2 Crystalline C22H29FO5 MW 392.5 N-(DIAMINOPHOSPHINYL)-4- 1 mg 7.25 159765 FLUOROBENZAMIDE 5 mg 18.65 DEXAMETHASONE 25 mg 11.95 RT [70788-28-2] 25 mg 74.55 194561 [50-02-2] 100 mg 29.00 (Flurofamine) 0-5oC (9α-Fluoro-16α-methylprednisolone) 500 mg 88.50 Urease inhibitor Cell Culture Reagent 1 g 132.00 C7H9N3O2PF MW 217.1 Crystalline 6 2 C22H29FO5 MW 392.5 N , O -DIBUTYRYLADENOSINE- 25 mg 20.75 105485 ′′′ ′′′ 50 mg 30.20 o 3 ,5 -cyclic-MONOPHOSPHATE (+)-DEXETIMIDE 1 mg 21.05 0 C [16980-89-5] 100 mg 53.00 150820 (3-phenyl-1′-(phenylmethyl)-[3,4′-bipiperidine 5 mg 31.80 Sodium Salt 500 mg 238.55 ]-2,6,-dione hydrochloride) C18H23N5O8PNa MW 491.4 Hydrochloride Ref.: (1) Spek, et al., Nature, 232, 575 N2, 2′′′-O-DIBUTYRYLGUANOSINE- 1 mg 14.85 (1971); (2) De Smedt, et al., J. Clin. 105486 ′′′ ′′′ 5 mg 46.00 o 3 ,5 -cyclic-MONOPHOSPHATE Pharmacol. 10, 207 (1970). 0 C [51116-00-8] 10 mg 85.00 (Dibutyryl-cGMP) 50 mg 392.00 DEXTROMETHORPHAN 250 mg 5.50 Sodium Salt 153544 [125-69-9] 1 g 11.00 Purity: 96% RT (3-Methoxy-17-methyl-9α,13α,- 5 g 18.50 Activates cGMP-dependent protein kinase 14α-morphinan hydrobromide) and inhibits thrombin induced arachidonic Hydrobromide acid release in human platelets. C18H25NO • HBr MW 352.3 Ref.: 1. Meyer, R.B. and Miller, J.P., Life Sci., 14, 1019 (1974). 2. Francis, S.G. et.al., ibid., 34, 506 (1988). 3. Schultz, K.D., DEXTRORPHAN-D-TARTRATE 50 mg 31.75 150 mg 80.20 et. al., Naunyn-Schmiedeberg’s Arch. 153741 [125-73-5] Pharmacol., 306, 1 (1979). 4. Sane, D.C, RT ((+)-3-Hydroxy-N-methylmorphinan-D-tartrate 250 mg 122.95 et.al., Biochem. Biophys. Res. Commun., ) , 708 (1989). Noncompetitive NMDA antagonist 165 C18H23N5O9PNa MW 507.4 C17H23NO • C4H6O6 MW 407.47 1 mg 7.50 DIACYLGLYCEROL KINASE 1 mg 19.95 5,6-DICHLOROBENZIMIDAZOLE 157639 RIBOSIDE 5 mg 23.50 152409 INHIBITOR I 5 mg 68.25 o 0-5oC 0 C [53-85-0] 10 mg 39.15 [93076-89-2] (DRB; 50 mg 150.00 (R59022; 6-[2-[4-[(4-fluorophenyl)phenyl- β methylene]-1-piperidinyl]ethyl]-7-methyl- 5,6-Dichloro-1- -D-ribofuranosylbenzimidazo 5H-thiazolo-[3,2-a]pyrimidin-5-one; DKI) le) The elevation of diacylglycerol Purity: 98% became of major importance when Selectively inhibits casein kinase II. Blocks diacylglycerol was shown to stimulate RNA synthesis by inhibiting RNA protein kinase C, making this lipid a polymerase II transcription dependent on candidate for a second messenger function CK-II in the signal transduction system. In intact Ref.: Zandomeni, R., et.al., J. Biol. Chem., cells, diacylglycerol is rapidly 261, 3414 (1986). phosphorylated into phosphatidic acid by C12H12Cl2N2O4 MW 319.1 diacylglycerol kinase and reverses the protein kinase C activity. 4,6-DICHLOROINDOLE-2- 1 mg 13.75 DKI was found to inhibit diacylglycerol 159769 CARBOXYLIC ACID 5 mg 32.00 kinase. In human red blood cell membranes RT Potent NMDA antagonist at the glycine site. 25 mg 140.00 and in intact platelets, the concentrations Reportedly stronger than kynurenic acid. needed for half maximal inhibition ranged Ref.: Salituro, et al., J. Med. Chem., 33, from 2 to 4 x 10-6M. 2945 (1990). C27H26N3OSF MW 459.6 C9H5NO2Cl2 MW 230.1

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 3,4-DICHLOROISOCOUMARIN 1 mg 28.50 2′′′,3′′′-DIDEOXYADENOSINE 5′′′- 1 mg 72.00 158836 [51050-59-0] 5 mg 115.00 157667 TRIPHOSPHATE 5 mg 315.00 0-5oC Reversible inhibitor of serine proteases, 10 mg 199.75 0oC [93939-70-9] including chymotrypsin, trypsin, clotting Lithium Salt factors XIa and XIIa. Also inhibits some Purity: 85% endopeptidase such as protease (Staph. 1 mg is approx. 2 µmoles. Inhibits chain V-8). Does not inhibit papain. elongation typically catalyzed by DNA Ref: Harper, J.W., et.al., Biochemistry, 24, polymerase I. 1831 (1985). Ref.: Sanger, F., et al., Proc. Nat. Acad. Sci. C9H4O2Cl2 MW 215 USA, 74, 5463 (1977). 5,7-DICHLOROKYNURENIC ACID 05 mg 14.95 2′′′,3′′′-DIDEOXYCYTIDINE 5′′′- 1 mg 120.00 158907 [131123-76-7] 25 mg 54.00 157668 TRIPHOSPHATE 5 mg 450.00 RT Purity: 99% 0oC [93939-77-6] Potent antagonist at the glycine site NMDA Lithium Salt receptor. Purity: 85% Ref.: 1. Baron, B.M., et.al., Mol. 1 mg is approx. 2 µmoles. Inhibitor of DNA Pharmacol., 38, 554 (1990). 2. Leeson, polymerase I - catalyzed chain elongation. P.D., et.al., J. Med. Chem., 34, 1243 (1991). Ref.: Sanger, F., et al., Proc. Nat. Acad. Sci. C10H5NO3Cl2 MW 258.1 USA, 74, 5463 (1977). ± cis-( )-3,4-DICHLORO-N-METHYL-N- 1 mg 17.50 1,9-DIDEOXYFORSKOLIN 159912 (2-[1-PYRROLIDINYL]CYCLO- 5 mg 75.00 RT HEXYL)BENZENEACETAMIDE 10 mg 127.00 See: Forskolin, 1,9-dideoxy [92953-41-8] (U-54494A) 2′′′,3′′′-DIDEOXYGUANOSINE 5′′′- 1 mg 131.70 157669 Hydrochloride o TRIPHOSPHATE Purity: 98% 0 C [93939-69-6] Potent NMDA antagonist Lithium Salt Ref.: Sethy, V.H. and Sage, G.P., Sage Purity: 90% Neuropharmacol., 31, 111 (1992). 1 mg is approx. 2 µmoles. Inhibitor of DNA MW 391.8 polymerase I - catalyzed chain elongation. Ref.: Sanger, F., et al., Proc. Nat. Acad. Sci. trans-(±)-3,4-DICHLORO-N-METHYL- 10 mg 27.00 USA, 74, 5463 (1977). 157646 50 mg 108.00 o N-(2-[1- 0-5 C PYRROLIDINYL]CYCLOHEXYL) 100 mg 200.00 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL 1 mg 91.70 158911 [100937-52-8] BENZENEACETAMIDE o [83913-06-8] 0-5 C Purity: 99% (U-50488H) Mannosidase inhibitor. Methanesulfonate Salt Ref.: Fleet, G.W.J., et.al., J. Chem. Soc. A kappa opioid agonist Chem. Commun., 1240 (1984). Ref.: 1. Gillan, M.G.C. and Kosterlitz, H., MW 163.2 Br. J. Pharmac., 77, 461 (1982). 2. 1 mg 7.50 VonVoigtlander, P.F., et al., J. Pharm. Exp. DIETHYLAMINE bis(NITRIC OXIDE) Ther., 224, 7 (1983). 193644 ADDUCT 5 mg 26.45 o 25 mg 110.00 C H Cl N O • CH SO MW 465.4 0-5 C Releases Nitric Oxide (NO) into aqueous 19 26 2 2 4 3 solutions. 5,7-DICHLOROTHIOKYNURENIC ACID 1 mg 8.95 C8H22N4O2 MW 206.3 159770 [135025-62-6] 5 mg 26.25 β 1 mg 10.75 -20oC (5,7-Dichloro-4-mercaptoquinoline-2-carboxy 3 -(2-DIETHYLAMINO- 158912 ETHOXY)ANDROSTENONE 5 mg 43.95 lic acid) RT NMDA receptor antagonist. (U-18666A) C H NO SCl MW 274.1 Hydrochloride 10 5 2 2 Purity: 99% DICLOFENAC 10 g 22.05 Inhibits 2,3-oxidosqualene-lanosterol 157660 25 g 49.00 cyclase activity prohibiting the biosynthesis [15307-79-6] of cholesterol. Also demonstrates inhibition RT (2-[(2,6-Dichlorophenyl)amino]-benzeneaceti 100 g 155.00 of the intracellular transport of c acid monosodium salt) LDL-Cholesterol in CHO cells. Sodium Salt Ref.: 1. Sexton, R.C., et.al., Biochemistry, Cyclooxygenase inhibitor 22, 5687 (1983). 2. Liscum, L. and Faust, C14H10Cl2NO2Na MW 318.1 J., J. Biol. Chem., 264, 11796 (1989). MW 424.1 (±)-1,2-DIDECANOYLGLYCEROL 1 mg 7.50 158909 5 mg 18.95 o (10:0) 10-(α-DIETHYLAMINO- 25 mg 26.10 -20-0 C [82950-64-9] 153738 PROPIONYL)-PHENOTHIAZINE 50 mg 47.70 (1,2-Didecanoyl-rac-glycerol (c10:0); RT Hydrochloride 100 mg 86.75 1,2-Dicaprin) C H N OS • HCl MW 362.9 Purity: 98% 19 22 2 Promotes protein kinase C in platelets. DIETHYLDITHIOCARBAMIC ACID 10 g 10.00 Ref.: 1. Go, M., et.al., Biochem. Biophys. 150889 [20624-25-3] 50 g 21.45 Res. Commun., 144, 598 (1987). 2. 0oC Trihydrate 100 g 35.70 Lapetina, E.G., et.al., J. Biol. Chem., 260, Sodium Salt 500 g 143.30 1358 (1985). Crystalline C23H44O5 MW 400.6 Reagent for copper determination. Also inhibits induction of macrophage nitric oxide 2′′′,5′′′-DIDEOXYADENOSINE 1 mg 29.00 synthase. 158910 [6698-26-6] 5 mg 125.00 C5H10NS2Na • 3H2O MW 225.3 0oC Purity: 98% 10 mg 215.00 Inhibitor of adeylate cyclase. 25 mg 475.00 1,3-DIETHYL-8-PHENYLXANTHINE 25 mg 28.85 Ref.: Holgate, S.T., et.al., Proc. Natl. Acad. 153739 [75922-48-4] 50 mg 55.70 o Sci. USA, 77, 6800 (1980). 0-5 C A1 Adenosine receptor antagonist 100 mg 101.25 C10H13N5O2 MW 235.2 C15H16N4O2 MW 284.3

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ N1, N12-DIETHYLSPERMINE 1 mg 12.75 3,4-DIHYDROXYPHENYL- 250 µCi 969.00 158913 Tetrahydrochloride 10 mg 64.20 16029 ETHYLAMINE, [8-14C] 1 mCi 2060.45 -20oC Purity: 98% 0-5oC (Dopamine) Demonstrates antineoplastic activity. Sp. Act. 40-60 mCi/mmol Inhibitor of polyamine synthesis. 1.48-2.22 GBq/mmol Ref.: Porter, C.W., et.al., Biochem. J., 268, Ethanol solution. 207 (1990). Please call for delivery information. MW 404.3 3,4-(OH)2C6H3CH2CH2NH2 MW 153.0

DIHYDREXIDINE 1 mg 30.85 3,4-DIHYDROXYPHENYL- 250 µCi 217.10 193645 Hydrochloride 3 o 26031 ETHYLAMINE, [7,8- H(N)] 1 mCi 447.50 0-5 C A potent D1 dopamine agonist that exhibits 0-5oC (Dopamine) 5 mCi 1332.80 no agonist activity at D2 receptors. Sp. Act. 30-60 Ci/mmol Ref.: Kohli, et al., Eur. J. Pharmacol., 235, 1.11-2.22 TBq/mmol 31 (1993). • Ethanol solution. C17H17NO2 HCl MW 303.8 Please call for delivery information. 3,4-(OH)2C6H3CH2CH2NH2 MW 153.0 DIHYDROCAPSAICIN See: 8-Methyl-N-vanillylnonanamide 3,4-DIHYDROXYPHENYL- 250 µCi 302.00 26032 ETHYLAMINE, [7-3H(N)] 1 mCi 605.15 o DIHYDROERGOCRYSTINE 25 mg 28.65 0-5 C (Dopamine) 159771 [24730-10-7] Sp. Act. 15-30 Ci/mmol RT Methanesulfonate Salt 0.555-1.11 TBq/mmol A 5-HT receptor antagonist. Ethanol solution. C35H41N5O5 • CH3SO3H MW 707.8 Please call for delivery information. 3,4-(OH)2C6H3CH2CH2NH2 MW 153.0 DIHYDROERGOTAMINE 10 mg 9.75 159772 [11032-41-0] 25 mg 18.50 3,4-DIHYDROXYPHENYL- 1 g 11.15 RT Methanesulfonate Salt 100 mg 58.25 101580 ETHYLAMINE 5 g 33.00 A 5-HT antagonist. 0-5oC [62-31-7] 25 g 145.50 C33H37N5O5 • CH3SO3H MW 679.8 (Dopamine, 3-Hydroxytyramine) Hydrochloride 3,4-DIHYDROXYBENZYLAMINE 25 mg 7.30 Purity: 99% 153740 [16290-26-9] 100 mg 13.50 Crystalline -20-0oC Hydrobromide 250 mg 28.95 Precursor of adrenaline. C7H9NO2 • HBr MW 220.1 C8H11NO2 • HCl MW 189.6

R(-)-2,11-DIHYDROXY-10- 1 mg 7.95 (±)-threo-DIHYDROXY- 1 mg 8.95 153737 5 mg 15.00 153736 5 mg 17.00 o METHOXYAPORPHINE PHENYLSERINE 0-5 C [6032-66-2] 25 mg 31.50 RT [3916-18-5] 25 mg 35.00 ((-)-Morphothebaine HCl) (±-threo-DOPS) Hydrochloride Noradrenaline precursor which elevates Dopamine receptor agonist noradrenaline concentrations in the brain. • C18H19NO3 HCl MW 333.8 C9H11NO5 MW 213.2

L-β-3,4-DIHYDROXYPHENYL- 250 mg 4.95 24(R),25-DIHYDROXYVITAMIN D3 50 µg 347.75 101578 ALANINE 1 g 9.95 158915 Purity: 99% RT 5 g 18.50 o [59-92-7] -20 C A significant vitamin D3 metabolite. Also, (L-Dopa, L-3-Hydroxytyrosine) 25 g 68.75 mediates homeostasis between calcium Purity: 99% 100 g 268.00 and phosphorus. Crystalline 500 g 650.00 Ref.: 1. DeLuca, H.F. and Schroes, H.K., Used in treatment of Parkinsonism. Also an Annu. Rep. Med. Chem., 19, 179 (1984). 2. inhibitor of tyrosine aminotransferase. Norman, A.W., Life Sci., 27, 229 (1980). C9H11NO4 MW 197.2 MW 416.6

DL 50 µCi 459.65 -3,4-DIHYDROXYPHENYLALANINE, 1 mg 12.50 16032 [Alanine-1-14C] DILAZEP 0-5oC 159774 [35898-87-4] 5 mg 31.00 (DL-Dopa) RT Inhibits adenosine uptake and platelet 3,4-(OH)2C6H3CH2CH(NH2)COOH aggregation; Coronary vasodilator. Sp. Act. 50-60 mCi/mmol C H N O MW 604.7 1.85-2.22 GBq/mmol 31 44 2 10 Ethanol solution MW 197.2 DILTIAZEM 1 g 31.25 151496 [33286-22-5] 5 g 118.50 o L-3,4-DIHYDROXYPHENYLALANINE, 250 µCi 593.05 0-5 C (cis-(+)-3-(Acetyloxy)-5-[2-(dimethyl-amino)et 10 g 211.95 26030 [Ring-2,5,6-3H] 1 mCi 1332.80 hyl]-2,3-dihydro-2-(4-methoxy-phenyl)-1,5-be o 0-5 C (L-Dopa) nzothiazepin -4(5H)-one) Sp. Act. 20-60 Ci/mmol Hydrochloride 0.74-2.22 TBq/mmol Calcium antagonist. Diltiazem HCl has 0.01N KH PO solution (pH 3.0). been found to inhibit contraction of smooth 2 4 muscles, especially coronary arteries. 3,4-(OH)2C6H3CH2CH(NH2)COOH MW 197.2 Crystalline C22H26N2O4S • HCl MW 451 3,4-DIHYDROXYPHENYL- 250 µCi 302.00 26033 ETHYLAMINE, [8-3H(N)] 1 mCi 605.15 DIMAPRIT 1 mg 8.00 0-5oC (Dopamine) 153733 [23256-33-9] 5 mg 17.00 Sp. Act. 15-30 Ci/mmol RT (S-(3-Dimethylaminopropyl)- 25 mg 35.00 0.555-1.11 TBq/mmol isothiourea dihydrochloride) Ethanol solution. Dihydrochloride Please call for delivery information. H2 Histamine agonist • 3,4-(OH)2C6H3CH2CH2NH2 MW 153.0 C6H15N3S 2HCl MW 234.2

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 3,4-DIMETHOXY- 5 ml 5.00 6,7-DINITROQUINOXALINE-2,3-DIONE 10 mg 36.75 150921 PHENETHYLAMINE 10 ml 7.40 158807 [2379-57-9] 50 mg 162.00 RT [120-20-7] 25 ml 16.00 RT (DNQX) (Homoveratrylamine) 100 ml 43.70 Purity: >98% Catecholamine involved in schizophrenia. Selective non-NMDA receptor antagonist. Ref.: Nature, 231, 22 (1971). Ref:1. Honore, T., et al., (1988), Science, 1 ml = 1.07 g 241, 701. C10H15NO2 MW 181.2 C8H4N4O6 MW 252.1 2-(2,6-DIMETHOXYPHENOXY- 10 mg 7.50 sn-1,2-DIOCTANOYLGLYCEROL 1 mg 10.50 154226 [60514-48-9] 5 mg 25.50 153583 ETHYL)AMINOMETHYL-1,4- 25 mg 15.00 o ≥ 0-5oC 100 mg 51.00 0-5 C Purity: 98% 10 mg 44.25 BENZODIOXANE Shipped with dry ice to reduce 50 mg 114.00 [613-67-2] isomerization on request only. 100 mg 192.15 (WB-4101) C H O MW 344.6 Hydrochloride 19 36 5 An α-adrenergic antagonist DIOCTANOYLGLYCOL 25 mg 18.35 Ref.: Norman, A.B., Molec. Pharmacol., 28, 159589 Inhibitor for diacylglycerol kinase. 100 mg 64.20 487 (1985). 0-5oC Ref.: Bishop, et al., J. Biol. Chem., 26, C19H23NO5 • HCl MW 381.9 6993 (1986). C18H34O4 MW 314.5 N,N-bis-(3,4-DIMETHOXY- 1 mg 13.75 159727 PHENYLETHYL)-N-METHYLAMINE 5 mg 42.40 (±)-DIOLEOYLGLYCEROL (18:1) 1 mg 12.95 158918 [3738-74-7] 5 mg 26.50 RT [33978-72-2] o (YS-035) -20-0 C (1,2-Dioleoyl-rac-glycerol (c18:1, 20 mg 86.00 Hydrochloride [cis]-9); A calcium blocker that also inhibits 1,2-Di[cis-9-octadecenoyl]-rac-glycerol) potassium outward currents. Purity: 98% C21H29NO4 • HCl MW 395.9 Shipped in dry ice to minimize isomerization C39H72O5 MW 621 6 N -[2-(3,5-DIMETHOXYPHENYL)-2-(2- 1 mg 14.75 DIOLEOYL-rac-GLYCEROL, 50 µCi 459.65 193647 METHYLPHENYL)ETHYL]ADENOSINE 5 mg 29.50 16028 [Oleoyl-1-14C] 250 µCi 1211.55 RT [120442-40-2] 25 mg 125.00 0-5oC (Diolein) (DPMA) Sp. Act. 1-5 mCi/mmol An A2 adenosine receptor agonist. 37-185 GBq/mmol C27H31N5O6 MW 521.3 Ethanol:toluene (1:1) solution. Please call for delivery information. 3,5-DIMETHYLADAMANTAN-1-AMINE MW 621.0 See: Memantine (+)-cis-DIOXOLANE 1 mg 19.00 153720 [16709-43-6] 5 mg 76.00 o 4-(N,N-DIMETHYLAMINO)BUTYLISOTHIOUREA 0-5 C (L(+)-cis-2-methyl-4-trimethyl- ammoniummethyl-1,3-dioxolane iodide) See: SK & F 91488 This product is a 60:40 mixture of cis,trans diastereomers as determined by NMR. 6-DIMETHYLAMINOPURINE 100 mg 14.25 C8H18INO3 MW 287.1 101593 [938-55-6] 250 mg 28.00 0oC (N6,N6-Dimethyladenine) 500 mg 45.50 DIPHENHYDRAMINE 10 g 14.00 Crystalline 1 g 74.75 190044 [147-24-0] 50 g 15.85 Purity: ≥98% RT (N-[2-Diphenylmethoxyethyl]-N,N-dimethylam 100 g 27.45 Protein kinase inhibitor. ine) Ref.: Szollosi, M.S., et al., Jour. of Cell Sci., Hydrochloride 37(23), 3886-3888 (1993). Crystalline C7H9N5 MW 163.2 Histamine H1 receptor antagonist C17H21NO • HCl MW 291.8 1,4-DIMETHYLENDOTHALL 1 mg 11.50 4-DIPHENYLACETOXY-N-METHYL- 1 mg 7.95 158916 [109282-27-1] 10 mg 57.05 o 158793 PIPERIDINE METHIODIDE 5 mg 19.00 0-5 C C10H14O5 MW 214.2 RT [1952-15-4] 25 mg 38.75 (4-DAMP) 100 mg 129.50 3,7-DIMETHYL-1- 1 mg 17.75 M3 muscarinic receptor antagonist. 193649 PROPARGYLXANTHINE 5 mg 68.35 Purity: >98% RT [14114-46-6] 25 mg 296.95 Ref: 1. Barlow, R.B. & Shepherd, M.K., (DMPX) (1986), Br. J. Pharmacol., 89, 837. Selective A2 adenosine receptor antagonist. 2. Michel, A.D., et al., (1989), Eur. J. C10H10N4O2 MW 218.2 Pharmacol., 166, 459. MW 451.4 1,3-DIMETHYLXANTHINE DIPHENYLAMINE-2-CARBOXYLIC ACID See: Theophylline See: N-Phenylanthranilic acid 3,5-DINITROCATECHOL 1 mg 11.00 DIPHENYLENEIODONIUM CHLORIDE 5 mg 18.00 153723 [7659-29-2] 5 mg 35.00 193650 [4673-26-1] 25 mg 71.85 RT (3,5-Dinitro-1,2-benzenediol) 25 mg 122.90 -20oC Purity: ≥98% Catechol O-methyl transferase (COMT) A powerful inhibtor of important enzymes inhibitor including NADH reductase, Oxidase and C6H4N2O6 MW 200.1 endothelial Nitric Oxide Synthase. Ref.: Dodd-O, J.M., et al., Brit. Jour. of 5,7-DINITROQUINOXALINE-2,3-DIONE 1 mg 30.95 Pharmacol., 120(5), 857-864 (1997). 159776 [125910-83-0] 5 mg 123.80 C H ClI MW 314.6 RT (MNQX) 12 8 Shows preferential antagonist activity at DIPHENYLENEIODONIUM SULFATE 5 mg 17.65 NMDA receptors. 193651 A Nitric Oxide Synthase inhibitor. 25 mg 52.90 o C8H4N4O6 MW 252.1 -20 C C12H18I • 1/2 SO4 MW 327.1 50 mg 94.80

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 1,3-DIPROPYL-8-(2-AMINO-4- 1 mg 13.25 DOXEPIN 1 g 19.75 153719 CHLOROPHENYL)-XANTHINE 5 mg 41.25 151016 [1229-29-4] 5 g 64.95 0-5oC [85872-51-1] 10 mg 75.05 RT (3-Dibenz(b,c)oxepin 10 g 108.00 (PACPX) 25 mg 147.75 11(6H)ylidene-N,N-dimethyl-1-propanamine) 50 g 285.00 Adenosine antagonist. Hydrochloride C17H19CIN5O2 MW 361.8 White crystalline powder C19H21NO • HCl MW 315.8 (±)-2-DIPROPYLAMINO- 1 mg 14.00 153718 5 mg 55.00 o 6,7-DIHYDROXY-1,2,3,4- -20-0 C TETRAHYDRONAPHTHALENE 10 mg 96.75 DOXORUBICIN 1 mg 16.75 [62421-17-4] 159101 [25316-40-9] 5 mg 66.25 (Dipropyl-6,7-ADTN HBr) RT (Adriamycin; 14-Hydroxydaunomycin, HCl) 10 mg 112.50 Hydrobromide Hydrochloride 50 mg 475.00 Dopamine agonist Purity: >95% by HPLC C16H25NO2 • HBr MW 344.3 Chemotherapeutic agent. Antitumor, immunosuppressive, and antibiotic agent. N,N-DIPROPYL-5-CARBOX- 1 mg 54.70 Blocks RNA polymerase and reverse 153724 AMIDOTRYPTAMINE transcriptase. Also inhibits nucleic acid -20-0oC (3-(N,N-Dipropylaminoethyl)-1H-indole-5-carb synthesis. oxamide maleate) Ref.: 1. McLoon, L.K., et.al., Invest. Maleate Salt Ophthamol. Vis. Sci., 32, 1667 (1991) 2. C17H25N3O • C4H4O4 MW 403.5 Ellis, C.N., et.al., Biochem. J., 245, 309 (1987). DIPROPYLDOPAMINE 10 mg 15.95 C27H29NO11 • HCl MW 580 153725 Hydrobromide 50 mg 62.90 0-5oC Dopamine receptor agonist 100 mg 72.25 C H NO • HBr MW 318.2 14 23 2 250 mg 120.65 DPMA 1,3-DIPROPYL-7-METHYLXANTHINE 1 mg 11.25 See: N6-[2-(3,5-Dimethoxyphenyl)-2-(2-methyl- 153726 [31542-63-9] 5 mg 36.15 phenyl)ethyl]adenosine RT C12H18N4O2 MW 250.3 10 mg 43.35 25 mg 65.10 1,3-DIPROPYL-8-PHENYLXANTHINE 1 mg 16.50 DSS 159779 Selective A1 adenosine antagonist. 5 mg 54.00 See: 3-(Trimethylsilyl)-1-propanesulfonic acid RT C17H20N4O2 MW 312.4 25 mg 225.00 1,3-DIPROPYL-8-p- 5 mg 36.15 153657 SULFOPHENYLXANTHINE 10 mg 65.10 o -E- 0-5 C [89073-57-4] 25 mg 143.15 C H N O S MW 392.4 17 20 4 5 E-64 1 mg 18.00 152846 [66701-25-5] 5 mg 59.00 DIPYRIDAMOLE 1 g 12.65 o 153722 [58-32-2] 5 g 37.50 -20-0 C (trans-Epoxysuccinyl-leucylamido- 10 mg 100.00 RT (2,2′,2′′,2′′′-(4,8-Dipiperidino- 10 g 61.00 [4-guanidino]butane; [L-3-trans-carboxy- pyrimido [5,4-d] pyrimidine-2,6- 25 g 120.00 oxiran-2-carbonyl]-Leu-agmatin) diyldinitrilotetraethanol) Inhibitor for thiol protease. Selective inhibitor of cGMP Ref: 1. Hanada, A., et al., Agric. Biol. phosphodiesterase and inhibits nucleoside Chem., 42, 529 (1978). transport into mammalian cells. 2. Barrett, A.J., et al., Biochem. J., 201, 189 C24H40N8O4 MW 504.6 (1982). C15H27N5O5 MW 357.4 1,3-DI(2-TOLYL)GUANIDINE 1 g 11.50 153721 [97-39-2] 5 g 39.50 RT C15H11N3 MW 239.3 E-64c 1 mg 64.00 195985 [76684-89-4] o DMPP 0-5 C ([2S,3S]-trans-Epoxysuccinyl-L-leucylamido-3 -methylbutane) See: 1,1-Dimethyl-4-phenylpiperazinium iodide Inhibitor for thiol protease. C15H26N2O5 MW 314.4 DNQX See: 6,7-Dintroquinoxaline-2,3-dione EBELACTONE A 1 mg 56.00 157894 [76808-16-7] DOBUTAMINE 1 mg 8.25 0-5oC (3,11-Dihydroxy-2,4,6,8,10,12-hexamethyl-9- 159780 [49745-95-1] 5 mg 16.25 oxo-6-tetradecenoic acid 1,3-lactone) RT Hydrochloride 10 mg 24.75 Inhibitor for esterase, lipase and β1-Adrenergic agonist. 50 mg 98.25 • N-formyl-methionine aminopeptidase. C18H23NO3 HCl MW 337.8 Ref.: Uotani, K., et al., J. Antibiotics, 35, 1670 (1982). DOMOIC ACID 0.5 mg 53.40 C H O MW 338.5 157890 [14277-97-5] 1 mg 88.90 20 34 4 0oC Purity: 95% 5 mg 295.00 Reported to be a potent glutamate agonist. Ref.: Briscoe, T.J., et al., British J. EBELACTONE B 1 mg 37.25 157895 [76808-15-6] Pharmacol., 58, 373 (1976). o C H NO MW 311.1 0-5 C (2-Ethyl-3,11-dihydroxy-4,6,8,10,12-pentame 13 21 6 thyl-9-oxo-6-tetradecenoic acid 1,3-lactone) DOMPERIDONE 5 mg 12.25 Inhibitor for esterase, lipase and 153709 [57808-66-9] 15 mg 24.55 N-formyl-methionine aminopeptidase. RT (5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benz 25 mg 38.35 Ref.: Uotani, K., et al., J. Antibiotics, 35, imidazol-1-yl)propyl]-4-piperidinyl]- 50 mg 72.25 1670 (1982). 1,3-dihydro-2H-benzimidazol-2-one) 250 mg 299.00 C21H36O4 MW 352.5 C22H24ClN5O2 MW 425.9

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ EBSELEN 20 mg 47.00 5,8,11,14-EICOSATETRAYNOIC ACID 5 mg 56.00 158809 [60940-34-3] 100 mg 151.00 151508 [1191-85-1] 25 mg 188.00 0oC (2-Phenyl-1,2-benzisoselenazol-3(2H)-one) 0oC (ETYA; Octadehydroarachidonic acid) 50 mg 315.00 Purity: >99% Supplied as a white solid Novel selenium-containing anti-flammatory Purity: 98% agent. Inhibits 5-LO, CO, NADPH oxidase, Archidonic acid, cyclooxygenase, and protein kinase C. Potent antioxidant. lipoxygenase, and cytochrome P450 inhibitor Possesses a unique glutathione Ref.: 1. Salari, H., et.al., Prostagland. peroxidase-like activity. Leukotrienes Med., 13, 53 (1984). 2. Taylor, Also shown to be an inhibitor of free radical A.S., et.al., Prostaglandins, 29, 449 (1985). induced apoptosis and neuroprotective 3. Bokoch, G.M., et.al., J. Biol. Chem., 256, agent. 4156 (1982). 4. Tobias, L.D., et.al., Lipids, Ref: Cotgreave, I.A., et al., (1989), 14, 181 (1979). 5. Falck, J.R., et.al., Biochem. Pharmacol., 38, 649. Biochem. Biophys. Res. Commun., 114, C13H9NOSe MW 274.2 743 (1983). C20H24O2 MW 296.4 cis-5,8,11-EICOSATRIENOIC ACID 1 mg 58.50 8,11-EICOSADIYNOIC ACID 1 mg 65.00 159104 [20590-32-3] 5 mg 263.00 159102 (EDYA) 0oC (MEAD acid; Eicosa-5z,8z,11z-trienoic acid, 10 mg 420.00 0oC Purity: 98% 20:3, n-9) Blocks arachidonic activity. Free Acid Ref.: Laposata, M., et.al., Prostaglandins, Purity: 95% 33, 603 (1987). Demonstrates immunomodulatory and MW 304.5 anti-inflammatory activity. Ref.: 1. Lefkowith, J.B., Adv. Prostagland. Thromboxane Leukotriene Res., 20, 224 (1990). 2. Schreiner, G.F., et.al., Science, cis-5,8,11,14,17-EICOSA- 10 mg 45.00 240, 1032 (1988). 151027 PENTAENOIC ACID 100 mg 265.00 C H O MW 306.5 0oC [10417-94-4] 20 34 2 (EPA) cis-5,8,11-EICOSATRIENOIC ACID 1 mg 87.00 This is the crucial eicosanoid precursor 159105 METHYL ESTER made available now as a high purity grade, 0oC [14602-39-2] purified by HPLC. (Mead acid methyl ester) Free Acid Purity: 99% Purity: 99% C21H36O2 MW 320.5 10 mg/ml in ethanol May contain <0.1% arachidonic acid. 5,8,11-EICOSATRIYNOIC ACID 1 mg 74.55 C H O MW 302.5 159106 [13488-22-7] 5 mg 332.55 20 30 2 0-5oC (ETI) 10 mg 630.65 Purity: 98% Specific lipoxygenase inhibitor. 5,8,11-EICOSAPENTAENOIC ACID 10 µCi 265.60 Ref.: 1. Salari, H., et.al., Prostagland. 16018 [1-14C] 50 µCi 641.55 Leukotrienes Med., 13, 53 (1984). 2. 0-5oC Sp. Act. 40-60 mCi/mmol Hammarstrom, S., Biochim. Biophys. Acta., 1.48-2.22 GBq/mmol 477, 517 (1977). 3. Hammarstrom, S., Ethanol solution. et.al., J. Biol. Chem., 255, 8023 (1980) Please call for delivery information. C20H28O2 MW 300.4 CH3CH2(CH=CHCH2)5(CH2)2COOH MW 306.2 ELASTATINAL 1 mg 21.45 152847 [51798-45-9] 5 mg 52.00 -20-0oC Source/Species: Microbial 10 mg 86.00 Purity: 50%. 8,11,14-EICOSAPENTAENOIC ACID 10 µCi 265.60 Inhibitor for elastase. 16019 14 50 µCi 641.55 Ref: Umezawa, H., et al., 26, 787 (1983). o [1- C] 0-5 C Sp. Act. 40-60 mCi/mmol C21H36N8O7 MW 512.6 1.48-2.22 GBq/mmol EMODIN 50 mg 35.00 Ethanol solution. 190453 [518-82-1] 250 mg 115.00 Please call for delivery information. 0-5oC (1,3,8-Trihydroxy-6-methylanthraquinone) CH3CH2(CH=CHCH2)5(CH2)2COOH From Frangula Bark MW 306.2 Purity: ∼98% A protein tyrosine kinase inhibitor. C15H10O5 MW 270.2 µ 5,8,11,14,17-EICOSAPENTAENOIC 10 Ci 544.55 ENDOTHALL 25 mg 34.65 16017 14 50 µCi 1090.25 o ACID [1- C] 158919 [145-73-3] 50 mg 66.20 0-5 C Sp. Act. 40-60 mCi/mmol 0-5oC (Endothal) 1.48-2.22 GBq/mmol A moderately potent inhibitor of protein Ethanol solution. phosphatase 2A. Please call for delivery information. C8H10O5 MW 186.16 CH3CH2(CH=CHCH2)5(CH2)2COOH MW 302.5 ENDOTHALL THIOANHYDRIDE 1 mg 71.10 158920 [109282-38-4] 5 mg 338.50 0-5oC A potent inhibitor of protein phosphatase 2A. C H O S MW 184.2 EICOSAPENTAENOIC ACID 50 µCi 314.10 8 8 3 26034 [5,6,8,9,11,12,14,15,17,18-3H] 250 µCi 847.70 prepro-ENKEPHALIN, 0.1 mg 29.70 0-5oC Sp. Act. 100-200 Ci/mmol 1 mCi 2060.45 152833 Fragment 128-140 0.5 mg 99.05 3.70-7.40 TBq/mmol -20-0oC [88878-74-4] 1 mg 159.80 Ethanol solution. (Gly-Gly-Glu-Val-Leu-Gly-Lys-Arg-Tyr-Gly-Gl Please call for delivery information. y-Phe-Met) CH3CH2(CH=CHCH2)5(CH2)2COOH Source/Species: Ovine, bovine MW 302.5 Carboxy terminal portion of peptide F. Ref: Micanovic, R., et al., Biochem. Biophys. Res. Commun., 118, 299 (1984). One call. One source. 1177 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ (±)-EPIBATIDINE 1 mg 99.00 EPIRUBICIN 1 mg 42.00 159918 [140111-52-0] 195984 [56390-09-1] -20oC From Poison Frog Skin 0-5oC (4′-Epidoxorubicin) Isolated from Epipedobates tricolor Hydrochloride Purity: 99% Purity: ≥95% Most potent agonist to the nicotinic Anti-tumor antibiotic which is less toxic than acetylcholine receptor known. Both doxorubicin. enantiomers have high affinity for nicotinic C27H29NO11 • HCl MW 580.0 receptors in rat brain membranes. Ref.: 1. Spande, T.F., et al., J. Am. Chem. ERBSTATIN ANALOG 5 mg 34.00 Soc., 114, 3475 (1992). 158813 [63177-57-1] 25 mg 124.00 2. Qian, C., et al., Eur. J. Pharmacol., 250, RT (Methyl 2,5-dihydroxycinnamate) R13 (1993). Purity: >98% 3. Badio, B. and Daly, J.W., Mol. Erbstatin is a novel inhibitor of the EGF Pharmacol., 45, 563 (1994). receptor associated tyrosine kinase1. It is C11H13N2Cl MW 208.7 an unstable compound and is completely µ 416.75 inactivated in serum in 30 minutes. Methyl EPIDERMAL GROWTH FACTOR 100 g 2,5-dihydroxycinnamate is a stable 691281 o RECEPTOR erbstatin analog retaining activity after a 60 -20 C MONOCLONAL ANTIBODY minute incubation. It inhibits EGF receptor Anti-Human associated tyrosine kinase in vitro 2 Clone: c11 (IC50=0.77 µM) . Inhibition is competitive Isotype: Ig fraction from mouse ascites with substrate and noncompetitive with ATP. Conc/Titer: 1:1,000 Ref: 1. Imoto, M., et al., (1987), Biochem. Applications: Immunoblotting; ELISA; Int., 15, 989. Immunohistochemistry 2. Umezawa, K., et al., (1990), FEBS Lett., The original immunogen was a synthetic 260, 198. peptide corresponding to a thirty residue region of the EGF receptor. The antibody 5 mg 15.00 reacts strongly with the EGF receptor in ERGOCORNINE human cell lines and does not react with 193652 [564-36-3] 25 mg 50.00 other phosphorylated proteins. RT An ergot alkaloid which acts as a dopamine agonist. EPIDERMAL GROWTH FACTOR RECEPTOR, Activated C31H39N5O5 MW 561.7 MONOCLONAL ANTIBODY Anti-Human ESCULETIN 1 g 27.00 Clone: 74 157942 [305-01-1] 5 g 109.00 Isotype: Ig fraction from mouse ascites 0-5oC (6,7-Dihydroxycoumarin; Esculetol) Conc/Titer: 1:1,000 Yellow crystals. Applications: Immunoblotting; ELISA; Immunohistochemistry; An inhibitor of 5-lipoxygenase and Immunocytochemistry 12-lipoxygenase, but does not inhibit The original immunogen was tyrosine-phosphorylated EGF cyclooxygenase. receptor. The antibody reacts strongly and preferentially with the C9H6O4 MW 178.1 activated and phosphorylated EGF receptor in human cell lines and does not react with other phosphorylated proteins. (-)-ESEROLINE FUMARATE 25 mg 80.00 691292 50 µg 325.25 153716 [104015-29-4] 50 mg 144.00 o 0-5 C C13H18N2O • C4H4O4 MW 334.4 691291 100 µg 504.95 EPIDERMAL GROWTH FACTOR 100 µg 139.90 ETAZOLATE 1 mg 17.20 694301 159592 [51022-77-6] 5 mg 56.00 o RECEPTOR o -20 C POLYCLONAL ANTIBODY 0-5 C Hydrochloride Inhibitor of phosphodiesterase IV Anti-Human • Host: sheep C14H19N5O2 HCl MW 325.8 Form: purified Ig fraction Conc/Titer: 1:50-1:500 ETHACRYNIC ACID 1 g 10.65 Applications: Immunoblotting 190203 [58-54-8] 5 g 32.25 The antibody was produced by RT ([2,3-Dichloro-4(2-methylene- 25 g 105.10 immunization with EGFr fragment. This butyryl)phenoxy] acetic acid) antibody has unique binding characteristics, Crystalline and it immunoprecipitates the receptor C13H12Cl2O4 MW 303.1 protein while leaving the mechanism of signal transduction (tyrosine 7-ETHOXYRESORUFIN 1 mg 51.30 phosphorylation) intact. It is effective across 157964 [5725-91-7] 5 mg 222.10 species for immunostaining fixed cultured 0oC (7-Ethoxy-3H-phenoxazin-3-one; Resorufin cell receptors in dilution ranges that are ethyl ether) dependent upon the receptor Fluorimetric substrate for detection of concentrations in the preparation. cytochrome P450 linked enzymes. Ref.: Burke, M.D., et al., Biochem. DL-EPINEPHRINE 1 g 10.00 Pharmacol., 34, 3337 (1985). 151064 [329-65-7] 5 g 16.50 o C14H11NO3 MW 241.2 0-5 C (DL-Adrenaline) 25 g 52.00 Crystalline 100 g 173.00 C9H13NO3 MW 183.2 ETHYL β-CARBOLINE-3-CARBOXYLATE β L-(-)-EPINEPHRINE 1 g 9.90 See: -Carboline-3-carboxylic acid ethyl ester 151065 [51-43-4] 5 g 31.80 o 0-5 C (L-Adrenaline) 10 g 57.00 5′′′-N-ETHYLCARBOXAMIDO- 10 mg 46.30 Metabolite of norepinephrine 153714 ADENOSINE 15 mg 65.10 C9H13NO3 MW 183.2 RT [78647-50-4] 25 mg 86.75 (NECA) L-(-)-EPINEPHRINE-(+)-BITARTRATE 1 g 9.00 195166 [51-42-3] 5 g 28.00 Adenosine agonist with affinity at A1 and A2 0-5oC Crystalline 25 g 97.00 receptors. C12H16N6O4 MW 308.3 C9H13NO3 • C4H6O6 100 g 267.00

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ N-ETHYLDEOXYNOJIRIMYCIN 1 mg 103.20 FLUO 3-AM 0.5 mg 150.20 158921 Purity: 99% 5 mg 412.75 158059 [121714-22-5] 1 mg 281.60 0oC HIV cytopathicity inhibitor. 0oC Fluorescent indicator for intracellular Ref.: Fleet, G.W.J., et.al., FEBS Lett., 237, calcium. 128 (1988). Ref.: Kao, J.P.Y., et al., J. Biol. Chem., 264, MW 191.2 8179 (1989). MW 1129.9 ETHYL 3,4-DIHYDROXY- 10 mg 30.00 159594 BENZYLIDENECYANOACETATE 50 mg 132.00 o 0-5 C [132464-92-7] N-(3-FLUORANTHYL)MALEIMIDE 1 mg 45.00 Inhibitor of 12-lipoxygenase. 158061 [60354-76-9] C12H11NO4 MW 233.2 0-5oC Fluorescent protein marker Ref.: Kanoaka, Y., et al., Chem. Pharm. ETHYLENEDIAMINETETRAACETIC 100 g 22.00 24 195173 ACID 250 g 44.00 Bull., , 1417 (1976) C H NO MW 297.3 RT [6381-92-6] 500 g 58.00 20 11 2 Disodium Salt 1 kg 88.00 Dihydrate 5-FLUOROINDOLE-2- Purity: 99% 100 mg 41.95 153704 CARBOXYLIC ACID 250 mg 83.90 Chelating agent. Produces colorless RT aqueous solutions. [399-76-8] C H N O Na • 2H O MW 372.2 Inhibitor of glycine potentiation at NMDA 10 14 2 8 2 2 receptor. 5-(N-ETHYL-N- 1 mg 13.25 C9H6NO2F MW 179.2 193653 ISOPROPYL)AMILORIDE 5 mg 44.10 RT [1154-25-2] 10 mg 79.40 (EIPA) 2-FLUOROPALMITIC ACID 5 mg 74.55 + + 159921 [16518-94-8] 25 mg 315.30 Inhibitor of the Na /H antiporter. o Ref.: Neylon, et al., J. Pharmacol. Exp. 0 C Purity: 98% Ther., 248, 991 (1989). Inhibitor of palmityl-CoA biosynthesis C11H18N7OCl MW 299.8 resulting in the blocking of protein palmitoylation. A posttranslational R(+)-ETICLOPRIDE 5 mg 37.00 modification reagent which palmitoylates G 153713 (R(+)-3-Chloro-5-ethyl-N- 10 mg 66.00 protein α-subunits, G proteins of low RT [(1-ethyl-2-pyrrolidinyl)methyl]-6- 25 mg 132.00 molecular weight, and p56. hydroxy-2-methoxybenzamide HCl) Ref.: 1. Abraham, N. and Veillette, A., Mol. Hydrochloride Cell. Biol., 10, 5197 (1990). 2. Hancock, C17H25ClN2O3 • HCl MW 377.3 J.F., et al., Cell, 57, 1167 (1989). 3. Soltysiak, R.M., et al., Biochim. Biophys. S(-)-ETICLOPRIDE 5 mg 32.00 Acta 792 153711 , , 214 (1984). [84226-12-0] 10 mg 58.00 MW 274.4 0-5oC (S(-)-3-Chloro-5-ethyl-N- 25 mg 116.00 [(1-ethyl-2-pyrrolidinyl)methyl]-6- hydroxy-2-methoxybenzamide HCl) 1-(2-bis-[4-FLUOROPHENYL]- Hydrochloride 5 mg 36.10 159924 METHOXYETHYL)-4-(3-PHENYL- 10 mg 59.65 Selective D2 dopamine receptor antagonist. RT 2-PROPYL)PIPERAZINE 50 mg 269.45 C H CIN O • HCl MW 377.3 17 25 2 3 [67469-78-7] (GBR 12909) -F- Hydrochloride cis,cis-FARNESYLPYROPHOSPHATE, 50 µCi 1211.55 Purity: 98% 26035 [1-3H] Inhibits the uptake of dopamine. 0-5oC Triammonium salt Ref.: 1. Heikkila, R.E., et al., Eur. J. Pharmacol. 103 Sp. Act. 15-30 Ci/mmol , , 241 (1984). 2. Teicher, 0.55-1.11 TBq/mmol M.H., et al., Dev. Brain Res., 30, 124 Ethanol solution. (1986). 3. Melia, K.F., et al., J. Pharmacol. Please call for delivery information. Exp. Therap., 258, 626 (1991). MW 433.43 MW 523.5 FARNESYLTHIOACETIC ACID 5 mg 131.90 159920 [135784-48-4] 10 mg 229.30 cis(Z)-FLUPENTHIXOL 50 mg 65.10 -20oC (FTA) 153702 [2709-56-0] 75 mg 94.00 Purity: 98% RT (4-[3-[2-Trifluoromethyl)-9H-thioxanthen-9-yli 100 mg 115.70 A posttranslational modification reagent dene]propyl]-1-piperazineethanol 2HCl) which specifically inhibits methyl Dihydrochloride esterification of farnesylated proteins. A dopamine antagonist Ref.: Tan, E.W., et al., J. Biol. Chem., 266, C23H25F3N2OS • 2HCl MW 507.5 10719 (1991). MW 296.5 trans-(E)-FLUPENTHIXOL FENVALERATE 10 mg 69.00 25 mg 52.50 193655 [53772-85-3] 25 mg 138.00 158922 [51630-58-1] 50 mg 95.00 RT Dihydrochloride -20-0oC Mixture of isomers A less potent dopamine antagonist than the Fenvalerate is a Type II pyrethrin and a cis-isomer. potent inhibitor of calcineurin (protein C H F N OS • 2HCl MW 507.5 phosphatase 2B). 23 25 3 2 C25H22ClNO3 MW 419.92 FLUNARIZINE 50 mg 25.35 FLUPHENAZINE 1 g 15.00 153701 153706 [146-56-5] 5 g 60.00 [52468-60-7] 100 mg 43.35 RT RT (1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2- 250 mg 101.25 (4-[3-[2-(Trifluoromethyl)-10H-pheno-thiazin-1 propenyl)-piperazine dihydrochloride) 0-yl]-1-piperazineethanol 2HCl) Dihydrochloride Dihydrochloride Crystalline A vasodilator and calcium channel • antagonist. C22H26F3N3OS 2HCl MW 510.4 C26H26F2N2 • 2HCl MW 477.4 One call. One source. 1179 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $

FLUPHENAZINE-N-2- 10 mg 22.00 FUMONISIN B2 1 mg 175.00 158925 CHLOROETHANE 25 mg 44.00 198781 [116355-84-1] 5 mg 595.00 RT [83016-35-7] -20-0oC From Fusarium moniliforme (SK & F 7171A, HCl) White powder. Hydrochloride Fungal metabolite Purity: 98% Inhibits sphingolipid biosynthesis. Potent and irreversible calmodulin Ref: E.Wang et al., J.Biol.Chem. 266 1486 inactivator. It also demonstrates (1991). antiproliferative and cytotoxic activity. C34H59NO15 MW 705.8 Ref.: Tanaka, T., et.al., Pharmacology, 26, 249 (1983). β-FUNALTREXAMINE 1 mg 163.40 MW 528.6 153708 [72786-10-8] 5 mg 719.25 0-5oC (βFNA; [E]-4-[[(5α,6β)-17-(cyclopropyl- 10 mg 1155.00 FLUPHENAZINE N-MUSTARD 25 mg 39.80 methyl)-4,5-epoxy-3,14-di- 153705 [83016-35-7] 50 mg 72.25 hydroxy-morphinan-6-yllamino]- RT [((2-Chloroethyl)-4-[3-(2-trifluoromethyl-10-ph 100 mg 130.15 4-oxo-2- butenoic acid methyl ester HCl) enothiazinyl)propylpiperazine)] Hydrochloride Dihydrochloride C25H30N2O6 • HCl MW 490.9 C H CIF N S • 2HCl MW 528.6 22 25 3 3 FURA 2 1 mg 95.00 152285 [96314-98-6] FLUPROSTENOL 1 mg 91.70 o 159115 [40666-16-8] 5 mg 412.00 0 C [1-(2-[5-Carboxyoxazol-2-yl]-6- -20oC ((±)16-(m-Trifluoromethylphenoxy)-tetranor-p aminobenzofuran-5-oxy)-2- (2′-amino-5′-methylphenoxy)ethane- rostaglandin F2α) ′ ′ Purity: 98% N,N,N ,N -tetraacetic acid] Ethanol solution Calcium-specific chelator indicator. MW 458.2 Calcium concentration may be measured directly using the ratio of fluorescence at FLUSPIRILENE 10 mg 108.45 510 nm produced by excitation at 340 nm 153707 [1841-19-6] 25 mg 216.95 and 380 nm. RT (R6218; 8-[4,4-Bis(p-fluorophenyl)butyl]- 50 mg 361.50 C29H27N3O14 MW 641.6 1-phenyl-1,3,8-triazino[4,5]decan-4-one) FURA 2-AM 0.5 mg 74.00 A dopamine antagonist 152286 [108964-32-5] 1 mg 123.00 C29H31F2N3O MW 475.6 RT This is the acetoxymethyl ester of FURA 2. Able to permeate cell membranes and load FORSKOLIN 1 mg 22.20 FURA 2 into cells. Inside cells, FURA 2-AM 190669 [66575-29-9] 5 mg 50.80 is rapidly hydrolyzed by cytoplasmic 0oC From Coleus forskohlii 10 mg 98.00 β α β α esterases. (7 -acetoxy-8,13-epoxy-1 ,6 ,9 -trihydroxy 25 mg 217.85 C44H47N3O24 MW 1001.9 -labd-14-ene-11-one) 50 mg 407.05 Reported to demonstrate positive inotropic FUREGRELATE 10 mg 16.50 and heart rate-increasing activity at low 158208 [85666-17-7] 50 mg 64.40 doses in animals. Also functions as an 0oC (5-[3-Pyridinylmethyl]benzo- 100 mg 115.80 antihypertensive and vasodilator at higher furancarboxylic acid) doses. Activates adenylcyclase in rat liver Sodium Salt membranes. Inhibitor of thromboxane synthetase. Ref.: H. Metzger and E. Lindner, I.R.C.S. C15H10NO3Na MW 275.2 Med. Sci., Biochem., Cardiovascular System Pharm., 9, 99 (1981). -G- C22H34O7 MW 410.5 GABACULINE FORSKOLIN, 7β-DEACETYL-7β-(γ-N- 1 mg 68.75 159596 METHYLPIPERAZINO)-BUTYRYL 5 mg 275.00 See: (±)-3-Amino-2,3-dihydrobenzoic acid 0oC Dihydrochloride Powerful activator of adenylate cyclase. GALANTHAMINE 5 mg 16.00 Water soluble derivative of forskolin. 159782 [357-70-0] 25 mg 48.00 MW 627.0 RT Cholinesterase inhibitor 100 mg 175.00 Hydrobromide FORSKOLIN, 1,9-DIDEOXY 1 mg 73.35 Ref.: Chopin and Bailey, Psychopharm., 159597 [64657-18-7] 5 mg 293.50 106, 26 (1992). o • 0 C Natural derivative of forskolin, but inactive. C17H21NO3 HBr MW 368.3 May be used as negative control. 1 g 34.50 C H O MW 378.5 GALLAMINE TRIETHIODIDE 22 34 5 158794 [65-29-2] 5 g 155.25 1 mg 137.60 RT Purity: > 95% FORSKOLIN, 7-O-HEMISUCCINYL-7- An M muscarinic antagonist with 151174 DEACETYL 2 0oC pronounced cardioselectivity. Acts via [83797-56-2] allosteric modulation of receptor binding. Soluble forskolin derivative useful for Ref: 1. Hammer, R., et al., (1986), Life Sci., preparation of probes. 38, 1653. Ref.: (1) T.P. Feuffer and H. Metzger, Febs 2. Nedoma, J., et al., (1986), J. Pharmacol. Letters, 146, 369 (1982); (2) N.J. Souza, Exp. Ther., 236, 219. A.N. Dohadwalla and J. Reden, Med. Res. 3. Michel, A.D., et al., (1990), Eur. J. Reviews, 3, 201 (1983). Pharmacol., 182, 335. C24H36O9 MW 468.6 4. Kenakin, T., et al., (1989), J. Pharmacol. Exp. Ther., 250, 944. FUMONISIN B1 1 mg 94.60 C H N O I MW 891.5 159925 [116355-83-0] 5 mg 429.95 30 60 3 3 3 o -20 C From Fusarium moniliforme GEA 3162 1 mg 13.75 Purity: 98% 159816 [144575-47-3] 5 mg 51.60 Sphingosine N-acyltransferase (ceramide 0-5oC (5-Amino-3-(3,4-dichlorophenyl)-1,2,3,4-oxat 25 mg 206.35 synthase) inhibitor which leads to blocking riazolium chloride) sphingolipid biosynthesis. Nitric Oxide (NO) donor. C34H59NO15 MW 721.8 C7H4N4OCl2 • HCl MW 267.6

To place an order: (800) 854-0530, fax (800) 334-6999 1180 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ GEA 5024 1 mg 13.75 trans,trans,cis-GERANYLGERANYL- 250 µCi 787.10 159817 [144575-27-9] 5 mg 51.60 26037 PYROPHOSPHATE, [1-3H] 0-5oC (5-Amino-3-(3-chloro-2-methylphenyl)-1,2,3,4 25 mg 206.35 0-5oC Triammonium salt -Oxatriazolium chloride) Sp. Act. 15-30 Ci/mmol A water soluble, stable nitric oxide (NO) 1.85-2.22 TBq/mmol donor. Ethanol solution. C8H7N4OCl • HCl MW 247.1 Please call for delivery information. MW 501.3 GELDANAMYCIN 100 µg 215.25 195994 [30562-34-6] -20oC From Streptomyces hygroscopius Purity: ≥95% GINKGOLIDE B 1 mg 11.20 Benzoquinoid antibiotic which is a potent 159928 [15291-77-7] 5 mg 38.45 inhibitor of pp60src tyrosine kinase and -20oC (BN 52021) 10 mg 59.65 c-myc gene expression in murine From Ginkgo Leaves 25 mg 120.40 lymphoblastoma cells. Purity: 90% C29H40N2O9 MW 560.6 Most potent PAF antagonist of the ginkgolide family. Inhibits both platelet GENISTEIN 10 mg 48.10 aggregation and PMNL chemotaxis induced 152355 [446-72-0] 50 mg 215.00 by PAF. 0oC (4,5,7-Trihydroxyiso-flavone) Ref.: 1. Nunez, D., et al., Eur. J. Highly specific inhibitor of tyrosine protein Pharmacol., 123, 197 (1986). kinases. Also inhibits EGF-stimulated 2. Tamura, N., et al., Biochem. Biophys. phosphorylation in cultured cells. Genistein Res. Commun., 142, 638 (1987). is an isoflavone compound isolated from C20H24O10 MW 424.4 the fermentation broth of Pseudomonas sp. C15H10O5 MW 270.2 GERANYLGERANIOL 25 mg 10.00 GLIAL DERIVED NEUROTROPHIC 10 µg 572.00 195777 FACTOR 198770 [24034-73-9] 100 mg 28.00 o 0oC Clear, colorless liquid. -20 C (GDNF) Useful for studying mammalian cell protein Rat, Recombinant isoprenylation. Sf 21 Expressed May affect regulation of cell cycle progress. Purity: ≥97% Ref: Crick, et al. Biochemical and Activity: ED50 = 1-3 ng/ml. Biophysical Research Commun. 237, 483 MW 290.5 trans-GERANYLGERANYL[1-d]- 1 mg 975.00 GLIAL FIBRILLARY ACIDIC PROTEIN 1 ml 211.00 691821 MONOCLONAL ANTIBODY 194792 PYROPHOSPHATE o -20oC (3,7,11,15-Tetramethyl-2,6-10,14-hexadecate -20 C (GFAP) traenyl pyrophosphate) Anti-Human Deuterated Clone: 8 Triammonium Salt Isotype: mouse IgG1 presented as tissue MW 501.5 culture supernatant Conc/Titer: 1:5-1:10 GERANYLGERANYLPYRO- 200 µg 91.85 Applications: ELISA; Immunoblotting 198736 PHOSPHATE 1 mg 183.75 The original immunogen was from human -20oC [6699-20-3] spinal cord. The antibody recognizes the (3,7,11,15-Tetramethyl-2,6-10,14-hexadecate 56Kd GFAP protein in immunoblots and ELISA. It can be used to discriminate glial traenyl pyrophosphate•NH3 Triammonium Salt tumors, including astrocytomas and Purity: 95% ependymomas from other tumors, such as A posttranslational modification reagent meningiomas, neuroblastomas, which is a geranylgeranyl-donor molecule chordomas, chondrosarcomas, used for isoprenylation of proteins lymphomas, and carcinomas. It is reactive accompanied by geranylgeranyltransferase. on both frozen and paraffin sections. Ref.: Seabra, M., et al., J. Biol. Chem., 267, 14497 (1992). C H O P • 3 NH MW 555.1 20 36 7 2 3 GLIAL FIBRILLARY ACIDIC PROTEIN 1 ml 179.45 µ 277.70 691102 MONOCLONAL ANTIBODY trans-GERANYLGERANYL- 50 Ci -20oC 26046 PYROPHOSPHATE, [1-3H] 250 µCi 653.65 (GFAP) 0-5oC 1514.75 Anti-Porcine Triammonium salt 1 mCi Clone: G-A-5 Sp. Act. 15-30 Ci/mmol Isotype: mouse IgG1 0.55-1.11 TBq/mmol Conc/Titer: 1:300 Ethanol solution Applications: PAP; Tissue sections Ref.: Seabra, M., et al., Science, 259, 377 The original immunogen was produced by (1993). the fusion of mouse myeloma cells and Please call for delivery information. mouse spleen cells immunized with purified MW 501.3 porcine GFAP. By use of well defined GFAP µ fragments, the antibody was shown to react trans-GERANYLGERANYL- 50 Ci 277.70 with the carboxyterminal Cys II fragment. It 26046H PYROPHOSPHATE, [1-3H] 250 µCi 653.65 o appears to be broadly cross-reactive 0-5 C Triammonium salt 1 mCi 1514.75 among species. Immunoblots on extracts of Sp. Act. 50-60 Ci/mmol the glioma cell line U333 CG/U343MG 1.85-2.22 TBq/mmol specifically visualize a single 51 kDa band. Ethanol solution Ref.: Seabra, M., et al., Science, 259, 377 (1993). Please call for delivery information. MW 501.3

One call. One source. 1181 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ GLIBENCLAMIDE 5 g 34.00 GLUTATHIONE REDUCED 5 g 32.25 157236 [10238-21-8] 10 g 61.00 194679 [70-18-8] 10 g 46.30 o o 0-5 C (Glyburide; glybenclamide; 0-5 C (γ-L-Glutamyl-L-cysteinylglycine) 25 g 97.00 N-p-[2-(5-Chloro-2-methoxybenzamido)- Cell Culture Reagent 100 g 315.00 ethyl]benzene-sulfonyl-N′-cyclohexylurea) Crystalline Purity: 98% Purity: 98-100% Selectively blocks ATP-sensitive K+ Useful tripeptide involved in many aspects channels and vascular smooth muscle of metabolism, including transport of relaxation. γ-glutamyl amino acids and reductive Ref.: 1. Schmid-Adomarchi, et.al., J. Biol. cleavage of disulfide bonds. Chem., 262, 15840 (1987). 2. Winquist, C10H17N3O6S MW 307.3 R.J., et.al., J. Pharmacol. Exp. Ther., 248, 149 (1989). 3. Fosset, M., et.al., J. Biol. GLUTATHIONE REDUCTASE 1 mg 50.60 100689 [9001-48-3] Chem., 263, 7933 (1988). 4. Miller, J.A., o et.al., J. Pharmacol. Exp. Ther., 256, 358 0-5 C From Baker’s Yeast (1991). 5. Cook, D.L. and Hales, C.N., E.C.1.6.4.2. Nature, 311, 271 (1984). Highly purified C23H28ClN3O5S MW 494 Crystalline suspension in 3.2M ammonium sulfate, pH 6.0. GLIPIZIDE 25 mg 13.75 Unit Definition: 1 unit oxidizes 1 µmole of 159797 [29094-61-9] 100 mg 32.05 glutathione/min. at 25°C, pH 5.5. RT An ATP-dependent potassium channel 500 mg 100.85 Activity: Approx. 120 units/mg. blocker. Contaminants: Essentially free of C21H27N5O4S MW 445.5 NADPH-Oxidase, 6-PGDH. PyroGLU-GLY-ARG-PHE AMIDE 25 mg 125.00 PyroGLU-VAL-ASN-PHE-SER-PRO- 1 mg 115.70 153102 [107535-01-3] 153104 5 mg 462.80 o GLY-TRP-GLY-THR-NH2 -20-0 C A neuropeptide originally isolated from the -20-0oC [106018-36-4] pennatulid Renilla koellikeri and the sea (Hypertrehalosaemic Neuropeptide) anemone Anthopleura elegantissima. A neuropeptide from the cockroach Ref: 1. Grimmelikhuijzen, C.J.P. and Graff, (Nauphoeta cinerea) with an amino acid D., Proc. Natl. Acad. Sci. (USA), 83, 9817 sequence similar to that of Adipokinetic (1986). Hormone I. 2. Grimmelikhuijzen, C.J.P. and Gregor, A., Ref: Gaede, G. and Rinehart, K.L., FEBS Lett., 211, 105 (1987). Biochem. Biophys. Res. Commun., 141, PyroGLU-SER-LEU-ARG-TRP AMIDE 1 mg 20.00 774 (1986). 153103 [114056-25-6] 5 mg 74.50 MW 1074.2 -20-0oC A neuropeptide originally isolated from sea 25 mg 298.00 anemones. GLYBURIDE Ref: Graff, D. and Grimmelikhuijzen, C.J.P., See: Glibenclamide Brain Res., 422, 354 (1988). GLYCOGEN SYNTHASE 1 U 72.50 L-GLUTAMIC ACID 100 g 9.00 195999 [9014-56-6] 5 U 290.00 101793 [56-86-0] 500 g 16.00 -20oC (UDO Glucose:glycogen RT (L-2-Aminopentanedioic acid) 1 kg 27.00 4-α-glucosyltransferase) Free Acid 5 kg 112.00 EC 2.4.1.11 Purity: 99-100% From Rabbit Muscle Crystalline Suspension in 60% glycerol with buffers. C5H9NO4 MW 147.1 Activity: ∼2-7 units/mg protein Unit Definition: one unit will catalyze the L-GLUTAMIC ACID 500 g 18.50 µ 194676 [56-86-0] 1 kg 30.00 incorporation of 1 mol of glucose from UDP-glucose into glycogen per minute at RT (L-2-Aminopentanedioic acid) 5 kg 125.00 ° Free Acid pH 8.2, 30 C. Cell Culture Reagent GOSSYPOL 25 mg 22.15 Purity: 99-100% 195210 [303-45-7] 100 mg 62.50 Crystalline 0-5oC Potential use as male contraceptive by 250 mg 125.25 C5H9NO4 MW 147.1 apparently inhibiting LH. Ref.: Poso, H., et al., Lancet, 1, 885 (1980). γ-D-GLUTAMYLAMINOMETHYL- 1 mg 16.40 157220 5 mg 64.20 C30H30O8 MW 518.6 o SULFONIC ACID 0 C [90237-02-8] 10 mg 115.60 GOSSYPOL-ACETIC ACID 25 mg 13.00 Kainate/quisqualate selective antagonist 195211 [12542-36-8] 100 mg 35.00 Ref.: Davies, J., et al., Comp. Biochem. 0oC Crystalline complex 250 mg 67.00 Physiol., 72, 211 (1982). Inhibits the autolytic conversion of C6H12N2O6S MW 240.2 pepsinogen to pepsin. 250 mg 18.05 Ref.: (1) Tanksley, T.D., Jr., et al., J. Biol. GLUTATHIONE OXIDIZED Chem., , 6456 (1970); (2) Wong, R.C., 151193 [121-24-4] 500 mg 28.90 245 o et al., J. Biol. Chem., 247, 1625 (1972). 0-5 C Anhydrous 1 g 45.30 C30H30O8•C2H4O2 (γ-L-Glutamyl-L-cysteinylglycine)2 5 g 206.35 Acts as hydrogen acceptor in enzymic GRANZYME B INHIBITOR 1 mg 105.00 determination of NADP and NADPH. 196000 (Z-Ala-Ala-Asp-CH2Cl; Z-AAD-CMK) o C20H32N6O12S2 MW 612.6 -20 C Purity: ≥95% Inhibits granzyme B present in cytoplasmic GLUTATHIONE REDUCED 1 g 12.40 granules of cytotoxic T-lymphocytes and 101814 [70-18-8] 5 g 25.15 o γ NK cells. 0-5 C ( -L-Glutamyl-L-cysteinylglycine) 10 g 35.55 C H N O Cl MW 441.9 Crystalline 25 g 70.00 19 24 3 7 Purity: 98-100% 50 g 133.60 GRIESS REAGENT 5 ml 19.55 Useful tripeptide involved in many aspects 100 g 239.00 159798 Reagent for determination of nitrite 25 ml 77.95 of metabolism, including transport of 0-5oC (NO-) in biological media. Consists of 0.1% γ-glutamyl amino acids and reductive naphthylethylenediamine HCl in distilled cleavage of disulfide bonds. H2O and 1% sulfanilamide in 5% H3PO4 C10H17N3O6S MW 307.3 (1:1 mixture) To place an order: (800) 854-0530, fax (800) 334-6999 1182 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ GTPase ACTIVATING PROTEIN 100 µg 651.00 GUANOSINE-5′′′-O-(2- 1 mg 17.20 694201 MONOCLONAL ANTIBODY 159033 THIODIPHOSPHATE) 5 mg 74.55 -20oC (GAP, Anti) -20oC [97952-36-8] Clone: GAP13 (GDP-β-S) Isotype: IgG1 Trilithium salt Conc/Titer: 1:1,000 Purity: >85% Applications: Immunoblotting A GDP analog which is a complete inhibitor Tyrosine phosphorylation of GAP, an of protein G activation by GTP and GTP activating protein for the GTPase activity of analogs. ras, is stimulated by several tyrosine Ref.: 1. Burch, R.M. and Axelrod, J., et.al., kinases, including EGF, PDGF, CSF-1 and Proc. Natl. Acad. Sci. USA, 84, 6374 several oncogene products. (1987). 2. Silk, S.T., et.al., J. Biol. Chem., The amino acid sequence of this peptide is 264, 21466 (1987). 3. Gilman, A.G., Annu. as follows: Rev. Biochem., 56, 615 (1987). NH2-Thr-Pro-Gly-Asp-Tyr-Ser-Leu-Tyr-Phe-A C10H12N5O10P2SLi3 MW 477.1 rg-COOH. The antibody is packaged at a GUANOSINE-5′′′-O-(3- 1 mg 56.15 concentration of 1 mg/ml in 40% glycerol, 159032 THIOTRIPHOSPHATE) 5 mg 258.00 20mM sodium phosphate, pH 7.5, 150mM -20oC [94825-44-2] 10 mg 484.75 NaCl, 3mM sodium azide. (GTPγS) A dilution of 1:1000 is suggested for Tetralithium salt Western Blot and other immunochemical Purity: >85% techniques. A GTP analog which activates protein G. Ref.: 1. Molloy, C.J., et al., Nature, 342, Ref.: 1. Silk, S.T., et.al., J. Biol. Chem., 264, 711-714 (1989). 2. Kaplan, et al., Cell, 61, 21466 (1989). 2. Gilman, A.G., Annu. Rev. 125-133 (1990). 3. Reedijk, M., Mol. Cell. Biochem., 56, 615 (1987). Biol., 10, 5601-5608 (1990). C10H12N5O13P3SLi4 MW 563 GUANOSINE-5’-TRIPHOSPHATE 10 mg 12.50 195213 [56001-37-7] 25 mg 20.00 GUANABENZ ACETATE 25 mg 20.95 o 193657 100 mg 74.95 0 C (GTP) 100 mg 60.00 [23256-50-0] Disodium Salt RT ([2,6-Dichlorobenzylidene)- 250 mg 102.00 amino]guanidine) Purity: 95-98% 500 mg 170.00 α Enzymatically prepared by phosphorylation 1 g 245.00 An 2-adrenergic agonist. of 5′-GMP. C8H8N4Cl2 • C2H4O2 MW 291.1 C10H14N5O14P3Na2 MW 567.2

5′′′-GUANYLYL-IMIDODIPHOSPHATE 5 mg 65.50 N-(2-GUANIDINOETHYL)-5- 5 mg 180.00 151204 [64564-03-0] 10 mg 120.55 0oC (GMP-PNP; Guanosine 25 mg 277.20 158926 ISOQUINOLINESULFONAMIDE 10 mg 299.00 ′ β γ 0oC [91742-10-8] 5 -[ , -imido]triphosphate tetralithium salt) (HA-1004) Tetralithium Salt Hydrochloride C10H13Li4N6O13P3 MW 545.9 Purity: 98% Inhibitor of PKA and PKG specifically over GUVACINE 100 mg 246.75 151219 [498-96-4] PKC and MLCK. Combined with H7 as a o probe for PKC-specific effects. 0-5 C (1,2,5,6-Tetrahydronicotinic acid) Ref.: 1. Hidaka, H., et.al., Biochemistry, 23, Hydrochloride GABA uptake inhibitor 5036 (1984). 2. Spangler, R., et.al., Proc. • Natl. Acad. Sci. USA, 86, 7017 (1989). C6H9NO2 HCl MW 163.5 C12H15N5O2S • HCl MW 329.8 -H- H-7 GUANOSINE-3′′′,5′′′-cyclic- 25 mg 13.45 101433 MONOPHOSPHORIC ACID 100 mg 41.35 See: 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine 0oC [40732-48-7] 250 mg 84.75 ′ ′ (3 ,5 -Cyclic GMP) 500 mg 127.55 H-8 Sodium Salt 1 g 211.75 Purity: ∼95% See: N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide C10H11N5O7PNa MW 367.2 H-9 See: n-(2-Aminoethyl)-5-isoquinolinesulfonamide GUANOSINE-5′′′-MONOPHOSPHATE 500 mg 6.35 100702 [5550-12-9] 1 g 8.25 0oC Disodium Salt 5 g 26.10 H-89 White crystalline powder 25 g 104.10 See: N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesul- Purity: 98-100% 100 g 369.00 fonamide We believe this is the best GMP available anywhere. Many dealers offer off-white powders with small amounts of HA-1004 contaminants and residual salt. Our See: N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide material shows only one spot by both TLC and electrophoresis and is also evaluated by UV absorption. HA-1077 C10H12N5O8PNa2 MW 407.2 See: 1-(5-Isoquinolinesulfonyl)homopiperazine

HA-156 See: 1-(8-Chloro-5-isoquinolinesulfonyl)piperazine

One call. One source. 1183 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ HALOENOL LACTONE SUICIDE 1 mg 45.90 N-HEPTYL-5- 1 mg 70.00 159932 SUBSTRATE 5 mg 189.20 158927 CHLORONAPHTHALENE-1- 5 mg 248.00 -20oC [88070-98-8] RT SULFONAMIDE (HELSS; [102649-79-6] E-6-(Bromomethylene)tetrahydro-3-(1-naphth (SC-10) alenyl)-2H-pyran-2-one). Purity: 99% Purity: 98% Protein Kinase C activator. Irreversibly and potently inhibits Ref.: Ito, M., et.al., Biochemistry, 25, 4179 calcium-independent phospholipase A2 (1986). (70% at 100 nm) 100 fold greater than C17H22ClNO2S MW 339.9 calcium-dependent PLA2. Ref.: 1. Hazen, S.L., et al., J. Biol. Chem., 266, 7227 (1991). HERBIMYCIN A 100 µg 122.00 158928 [70563-58-5] 2. Lehman, J.J., et al., J. Biol. Chem., 268, o 20713 (1993). -20-0 C From Streptomyces hygroscopicus Irreversibly inhibits tyrosine kinsases. Also, inhibits thrombin-stimulated tyrosine HALOPERIDOL 500 mg 12.00 phosphorylation of phospholipase C. 153696 [52-86-8] 1 g 17.00 Antibiotic against Src, Yes, Fps, Ros, and, RT (4-[4-(4-Chlorophenyl)-4-hydroxy- 5 g 35.00 Erb oncongene reagents. 1-piperidinyl]-1-(4-fluorophenyl)- Ref.: 1. Uehara, Y. and Fukazawa, H., 1-butanone) Methods Enzymol., 201, 370 (1991). 2. Dopamine antagonist Fukazawa, H., et.al., Biochem. Pharmacol., C21H23ClFNO2 MW 375.9 42, 1661 (1991). 3. Satoh, T., et.al., J. Biol. Chem., 267, 2537 (1992). 4. Weiss, R. and HALOPERIDOL 5 mg 33.00 Nuccitelli,R., J. Biol. Chem., 267, 5608 153692 [59995-68-5] 10 mg 59.00 (1992). RT (4-[4-(4-Chlorophenyl)-4-hydroxy- 25 mg 118.00 1-piperidinyl]-1-(4-chlorophenyl)- 1-O-HEXADECYL-2-O-ACETYL-sn- 5 mg 74.55 1-butanone) 159118 GLYCEROL 10 mg 131.90 Chlorinated Analog -20oC [77133-35-8] 25 mg 315.30 C21H23NO2Cl2 MW 392.3 Purity: 98% Protein kinase C inactivator. Also acts as a HALOPERIDOL METABOLITE I 10 mg 21.75 platelet activating factor precursor. 153695 [39512-49-7] 15 mg 28.85 Ref.: 1. Daniel, L.W., et.al., ibid., 151, 291 RT (4-(4-Chlorophenyl)-4-hydroxy- 25 mg 43.35 (1988). 2. McNamara, M.J.C., et.al., ibid., piperidine) 122, 824 (1984). 3. Lee, T.C., et.al., J. Biol. C11H14ClNO MW 211.7 Chem., 265, 9181 (1990). C21H42O4 MW 358.6 HALOPERIDOL METABOLITE II 15 mg 86.00 153694 [34104-67-1] 25 mg 120.40 1-O-HEXADECYL-2-O-ACETYL-sn- 1 mg 66.45 RT Reduced Haloperidol 50 mg 206.35 159119 GLYCERO-3-PHOSPHO-(N,N,N- 5 mg 298.10 ((±)-4-(4-Chlorophenyl)-α-(4- -20oC TRIMETHYL)HEXANOLAMINE fluorophenyl)-4-hydroxy-1-piperidinebutanol) [99103-16-9] C21H25ClFNO2 MW 377.9 Purity: 98% Blocks platelet aggregation, secretion, and HALOPERIDOL METABOLITE III 10 mg 21.75 the production of IP3 induced by platelet 153693 [366-77-8] 15 mg 28.85 activating factor (PAF). PAF antagonist. RT (3-(4-Fluorobenzoyl)propionic acid) 25 mg 43.35 Ref.: 1. Tokumura, A., et.al., J. Biol. Chem., C H FO MW 196.2 260, 12710 (1985). 2. Rouis, M., et.al., 10 9 3 Biochem. Biophys. Res. Commun., 20, (suppl. II), 20 (1988). 3. Buxton, D.B., et.al., HDBA 2 mg 90.85 Biochem. Pharmacol., 35, 893 (1986). 158814 (2-Hydroxy-5-(2,5-dihydroxy- 10 mg 364.35 C30H62NO7P MW 579.8 -20oC benzylamino)benzoic acid) Purity: > 98% 2+ 5 mg 183.45 Inhibits Ca /calmodulin kinase II (IC50=0.2 1-O-HEXADECYL-2-O-DOCOSA- 1 159121 10 mg 338.25 µM) . Also inhibits EGF receptor tyrosine o HEXAENOYL-sn-GLYCERO- 2 c-src(+) -20 C kinase (IC50=0.044 µM) and pp60 3-PHOSPHORYLCHOLINE 1 kinase (IC50 = 0.5 µM) . Purity: 98% MW 275.3 PAF precursor in the lipid remodeling Ref: 1. O’Dell, T.J., et al., (1991), Nature, pathway. 353, 558. Ref.: Lee, T.C., et.al., J. Biol. Chem., 265, 2. Takahashi, I., et al., (1989), Biochem. 4181 (1990). Biophys. Res. Comm., 165, 1207. MW 792.2

HEAT 5 mg 49.60 HEXAMETHONIUM CHLORIDE 5 g 8.50 193658 [30007-39-7] 10 mg 90.40 101936 [60-26-4] 25 g 33.00 -20oC (2-{[β-(4-Hydroxyphenyl)- RT (Hexane-1,6-bis[trimethylammonium 100 g 115.00 ethyl]aminomethyl}-1-tetralone) chloride]) Hydrochloride Purity: ∼99% A selective α1-adrenoceptor agonist. C12H30Cl2N2 MW 273.3 C19H21NO2 • HCl MW 331.8 N-HEXANOYL-D-erythro- 50 µCi 726.45 25 mg 10.00 26038 3 HEMICHOLINIUM-3 o DIHYDROSPHINGOSINE, [4,5- H] 151231 [312-45-8] 100 mg 20.00 0-5 C Sp. Act. 30-60 Ci/mmol 0oC (2,2′-[4,4′-Biphenylene]-bis-[2-hydroxy-4,4-di 250 mg 47.60 1.11-2.22 TBq/mmol methylmorpholinium bromide]) Ethanol solution. Purity: ∼95% Please call for delivery information. C24H34Br2N2O4 MW 574.4 MW 399.5

To place an order: (800) 854-0530, fax (800) 334-6999 1184 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ N-HEXANOYL-D-erythro- 50 µCi 726.45 HISTONE H1 PHOSPHORYLATION 1 mg 68.75 16020 DIHYDROSPHINGOSINE, 159599 SITE 0-5oC [Hexanoyl-1-14C] 0oC Arg-Arg-Lys-Ala-Ser-Gly-Pro-OH Sp. Act. 25-50 mCi/mmol Substrate for protein kinase C. The 0.925-1.85 GBq/mmol phosphorylation site corresponds to Ser38 in Ethanol solution. calf thymus histone H1. Please call for delivery information. MW 770.9 MW 399.5 HOMOHARRINGTONINE 1 mg 30.00 157386 [26833-87-4] 5 mg 119.00 N-HEXANOYL-D-SPHINGOSINE 1 mg 13.00 o 158931 [124753-97-5] 5 mg 58.85 0-5 C Alkaloid from Cephalotaxus hainanensis. 10 mg 189.00 o -20-0 C (C6 Ceramide; N-Caproyl-D-sphingosine; Reported to possess anti-leukemic activity. Caproyl ceramide) Ref.: Mikolajczak, K.L. and Smith, C.R., J. Purity: 98% Org. Chem., 43, 1762 (1978). Stimulates cytosolic serine/threonine C29H39NO9 MW 545.6 protein phosphatase in T9 cells and induces the phosphorylation on Thr-669 in 5-HTQ A-431 cells. See: Trimethylserotonin iodide Ref.: 1. Dobrowsky, R.T. and Hannun, Y.A., et.al., J. Biol. Chem., 267, 5048 (1992). 2. (±)-HUPERZINE A 1 mg 65.00 158796 [102518-79-6] 5 mg 294.00 Mathias, S., et.al., Proc. Natl. Acad. Sci. o USA, 88, 10009 (1991). 0 C A potent acetylcholinesterase inhibitor. Nootropic agent. Improves memory and HISTAMINE 1 g 26.20 learning in animal models. 190212 [51-45-6] 5 g 111.55 Purity: > 98% 0oC (2-[4-Imidazolyl]ethylamine) Ref: Tang, X.C., et al., (1986), Acta Pharm. Free Base Sin., 7, 507. Crystalline 2. Zhang, S.-L., (1986), New Drugs Clin. Packaged in sealed ampule Remedies,5, 260. C5H9N3 MW 111.1 C15H18N2O MW 242.3 HISTAMINE 5 g 13.75 HYDRALAZINE 5 g 20.00 100340 [56-92-8] 10 g 20.65 151278 [304-20-1] 10 g 32.50 RT (2-[4-Imidazolyl]-ethylamine 2HCl) 25 g 44.65 RT (1-Hydrazinophthalazine; Apresoline) 50 g 108.00 Dihydrochloride Hydrochloride Crystalline Crystalline Purity: 98% Monoamine Oxidase inhibitor • C5H9N3 • 2HCl MW 184.1 C8H8N4 HCl MW 196.6 HISTAMINE DIPHOSPHATE 1 g 7.50 HYDROCHLOROTHIAZIDE 5 g 12.90 100343 [51-74-1] 5 g 24.45 157403 [58-93-5] 25 g 40.65 0oC Crystalline 25 g 92.00 RT (6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzo 100 g 110.50 C H N • 2H PO MW 307.2 thiadiazine 1,1-dioxide) 5 9 3 3 4 Crystalline HISTAMINE ELISA KIT 1 each 735.00 A carbonic anhydrase inhibitor 193590 This Histamine ELISA kit provides materials C7H8ClN3O4S2 MW 297.7 o G 0-5 C for the quantitative measurement of N -HYDROXY-L-ARGININE 5 mg 70.00 acylated histamine in plasma, urine, and 193661 [53054-07-2] 10 mg 130.00 cell culture supernatants. The assay 0-5oC Acetate Salt procedure follows the basic principle of Intermediate in the conversion of L-arginine competitive ELISA whereby there is into nitric oxide (NO) and citrulline. competition between biotinylated and C H N O • C H O MW 250.2 non-biotinylated antigen for a fixed number 6 14 4 3 2 4 2 of antibody binding sites. The kit is a 12 x 8 L-(-)-threo-β-HYDROXYASPARTIC 1 mg 25.00 well format. 193663 ACID 5 mg 90.00 RT [7298-99-9] FOR RESEARCH USE ONLY! Neurotoxic inhibitor of L-glutamic acid and L-aspartic acid uptake. HISTAMINE RELEASE ASSAY KIT 1 each 44.10 C4H7NO5 MW 149.1 193591 This assay measures the release of 0-5oC histamine which occurs upon stimulation of 3-HYDROXYBENZYLHYDRAZINE 250 mg 20.00 basophilic granulocytes depending upon 153699 [81012-99-9] their sensitivity to an allergen. Heparinized RT (α-Hydrazino-m-cresol) whole blood samples are incubated with Dihydrochloride different concentrations of the suspected Centrally acting dopamine decarboxylase allergen. The released histamine in the inhibitor; penetrates the bloodbrain barrier. supernatant is subsequently determined C7H10N2O • 2HCl MW 211.1 using a specific plasma immunoassay, such (±)-4-HYDROXYDEBRISOQUIN 5 mg 22.95 as the Histamine ELISA Kit (Cat. No. 158932 [59333-79-8] 10 mg 43.90 193590) from ICN. The kit contains RT Purity: 99% 25 mg 106.60 sufficient materials for 96 assays when Metabolite of debrisoquin. Also an indicator 50 mg 208.70 used in connection with the Histamine for cytochrome p-450 polymorphism. ELISA kit. Ref.: 1. Idle, J.R., et.al., Br. J. Clin. Pharmacol., 7257 (1979). 2. Guengerich, FOR RESEARCH USE ONLY! F.P., Trends Pharmacol. Sci., 10, 107 L-HISTIDINOL 100 mg 20.50 (1989). 101948 [1596-64-1] 250 mg 38.90 C10H13N3O MW 191.2 RT Dihydrochloride 500 mg 65.20 5-HYDROXYDECANOIC ACID 25 mg 22.05 Crystalline 1 g 111.30 193664 [624-00-0] 100 mg 79.40 Powerful, reversible inhibitor of protein 5 g 445.25 RT Sodium Salt synthesis. A normal precursor of A K+ channel antagonist which blocks the procaryotes and eucaryotes. post-ischemic effects of the K+ channel Ref.: J. Bio. Chem., 26, 3854 (1972). activator cromakalim. • C6H11N3O 2HCl MW 214.1 C10H19O3Na MW 210.2 One call. One source. 1185 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ (±)-7-HYDROXY-2-DIPROPYL- 5 mg 32.05 2-(5-HYDROXY-3-INDOLYL)ETHYLTRI- 5 mg 59.00 159936 AMINOTETRALIN 10 mg 51.60 159938 METHYLAMMONIUM IODIDE 10 mg 99.75 RT [94938-11-7] 25 mg 114.65 RT (5-HTQ-(N,N,N-trimethylserotinin iodide) 25 mg 217.85 ((±)-7-OH-DPAT) 50 mg 212.10 Purity: 98% Hydrobromide Agonist of serotinin 5-HT3. Purity: 98% Ref.: Richardson, B.P., et al., Nature, 316, Selective agonist for D3 dopamine 126 (1985) Ref.: Zhuang, Z.P., et al., J. med. Chem., MW 346.2 36, 1499 (1993). C16H26NO • HBr MW 329.3 3-HYDROXY-DL-KYNURENINE 5 mg 13.75 102003 [2147-61-7] 25 mg 48.20 (±)-8-HYDROXY-2-DIPROPYL- 25 mg 106.30 0-5oC (α,2-Diamino-3-hydroxy- 100 mg 169.70 158933 AMINOTETRALIN 50 mg 192.05 γ-oxobenzenebutanoic acid) RT [87394-87-4] 100 mg 366.90 Monamine Oxidase Substrate ((±)-8-Hydroxy-DPAT) Crystalline Hydrobromide C10H12N2O4 MW 224.2 Purity: 99% Specific 5-HT1A agonist. 6-HYDROXYMELATONIN 50 mg 142.05 Ref.: Middlemiss, D.N., et.al., Eur. J. 154151 [2208-41-5] 100 mg 250.00 Pharmacol., 90, 151 (1983). 0-5oC Crystalline C16H25NO • HBr MW 328.3 Metabolite of melatonin. C H N O MW 248.3 6-HYDROXYDOPAMINE 50 mg 37.50 13 16 2 3 105657 [636-00-0] 100 mg 56.15 o DL-3-HYDROXY-4- 250 mg 26.35 0 C (2,4,5-Trihydroxyphenethylamine 250 mg 112.35 159147 METHOXYMANDELIC ACID 500 mg 45.90 hydrobromide) 500 mg 187.30 0-5oC [3695-24-7] 1 g 74.55 Hydrobromide (Isovanillylmandelic acid) Crystalline Purity: ∼99% Free Acid Useful pharmacological tool. Purity: 99% Selectively destroys adrenergic receptor C9H10O5 MW 198.2 sites. C H NO • HBr MW 250.1 DL-4-HYDROXY-3-METHOXY- 250 mg 15.00 8 11 3 105689 500 mg 25.00 o MANDELIC ACID 7-(β-HYDROXYETHYL)- 1 g 11.45 0-5 C [55-10-7] 1 g 45.00 153541 THEOPHYLLINE 5 g 34.40 (Vanillylmandelic acid; 5 g 180.00 0-5oC [519-37-9] α,4-Dihydroxy-3-methoxybenzeneacetic (1,3-Dimethyl-7-(β-hydroxyethyl- acid; VMA) xanthine) Crystalline C9H12N4O3 MW 224.2 A metabolite of epinephrine. C9H10O5 MW 198.2 α-HYDROXYFARNESYL- 1 mg 218.00 159937 PHOSPHONIC ACID 2-HYDROXYMYRISTIC ACID 10 mg 21.45 -20oC 159939 [2507-55-3] 25 mg 45.30 [140633-12-1] o Purity: 96% 0 C (DL-α-Hydroxymyristic acid; 50 mg 82.60 Potently inhibits farnesyltransferase in 2-Hydroxytetradecanoic acid) certain enzyme assays and in complete Purity: 98% cells. It is more selective than A posttranslational modification reagent geranylgeranyltransferases I and II. which inhibits protein myristoylation after Ref.: 1. Gibbs, J.B., et al., J. Biol. Chem., metabolic activation. A useful tool for 268, 7617 (1993). differentiating myristoylation and 2. Pompliano, D.L., et al., Biochemistry, 31, palmitoylation of proteins. It prevents p56 3800 (1992). mediated signal transduction and stops MW 302.4 Varicella zoster virus replication. Ref.: 1. Abraham, N. and Veillette, A., Mol. 5-HYDROXYINDOLE-3-ACETIC ACID 100 mg 15.65 Cell. Bio., 10, 5197 (1990). 102004 [66866-39-5] 500 mg 55.85 2. Spiegel, A.M., et al., Trends Biochem. 0oC Dicyclohexylammonium Salt 1 g 97.05 Sci., 16, 338 (1991). White crystals 3. Paige, L.A., et al., J. Biol. Chem., 268, Purity: 99+% 8669 (1993). C10H9NO3 • C12H23N MW 372.5 C14H28O3 MW 244.4 5-HYDROXYINDOLE-3-ACETIC ACID 25 mg 10.90 102005 [1321-73-9] 100 mg 21.20 1-HYDROXY-2-OXO-3-(3-AMINOPROPYL)-3-ISOPROPYL- 0oC Free Acid 500 mg 83.10 1-TRIAZENE Purity: 98-100% 1 g 126.10 See: NOC-5 Metabolite of serotonin Light yellow crystals C H NO MW 191.2 4-HYDROXYPHENYLRETINAMIDE 1 mg 39.85 10 9 3 159942 [65646-68-6] 5 mg 181.10 o 5-HYDROXY-3-INDOLE ACETIC ACID 1 each 585.00 -20 C Purity: 97% 10 mg 315.30 193592 ELISA KIT Demonstrates anti-proliferative activity on 0-5oC (5-HIAA ELISA) human breast cancer cells in culture. This 5-HIAA enzyme immunoassay kit Induces malignant hemopoietic cell line provides materials for the quantitative apoptosis. measurement of chemically derivatized Ref.: 1. Marth, C., et al., J. Natl. Cancer 5-HIAA in urine. The assay procedure Inst., 75, 871 (1985). 2. Grubbs, C.J., et al., follows the basic principle of competitive Anticancer Res., 10, 661 (1990). 3. Delia, ELISA, whereby there is competition D., et al., Cancer Res., 53, 6036 (1993). between biotinylated and non-biotinylated MW 391.5 antigen for a fixed number of antibody binding sites. This kit is a 12 x 8 format. 2-HYDROXYSACLOFEN FOR RESEARCH USE ONLY! See: 3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-sulfonic acid

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ HYDROXYTACRINE 25 mg 36.15 153690 [112964-99-5] 50 mg 57.80 -I- RT (HP-029) 100 mg 108.45 (9-Amino-1,2,3,4-tetrahydro- IBERIOTOXIN 100 µg 590.50 acridine-1-(2H)-ol maleate) 158935 [129203-60-7] Maleate Salt -20-0oC From Buthus tamulus Scorpion Cholinesterase inhibitor • Purity: 98% C13H14N2O C4H4O4 MW 330.3 More specific than charybdotoxin at inhibiting high conductance Ca2+-activated K+ channel via allosteric inhibition. Ref.: Galvez, A., et.al., J. Biol. Chem., 265, 5-HYDROXYTRYPTAMINE 25 mg 15.00 11083 (1990). 153765 [153-98-0] 50 mg 25.00 MW 4231.8 0-5oC (Serotonin HCl) 100 mg 40.00 Hydrochloride 250 mg 81.00 A neurotransmitter 1 g 225.00 C10H12N2O • HCl MW 212.7

IBOTENIC ACID 1 mg 79.00 5-HYDROXYTRYPTAMINE 100 mg 16.00 190215 [2552-55-8] 5 mg 239.00 102885 [3036-16-6] 1 g 115.00 RT (α-Amino-3-hydroxy-5-isoxazole acetic 0-5oC (Serotonin hydrogenoxalate) acid) Oxalate Salt Isolated from wild Amanita pantherino. Light tan crystals Crystalline ∼ C10H12N2O • C2H4O4 MW 266.3 Purity: 95% Used in study of the GABA-nergic system. Also see: Muscimol. C5H6N2O4 MW 158.1 5-HYDROXY-L-TRYPTOPHAN 250 mg 9.50 100751 [4350-09-8] 1 g 17.00 0oC Purity: 99% 5 g 50.00 Crystalline 25 g 199.00 Precursor of serotonin C H N O MW 220.2 11 12 2 3 IBUPROFEN 1 g 15.90 190216 [15687-27-1] 5 g 60.20 RT (α-Methyl-4-[2-methylpropyl] 10 g 107.45 benzeneacetic Acid) 25-HYDROXYVITAMIN D3 1 mg 63.05 Crystalline 158934 [19356-17-3] 5 mg 286.65 o An anti-inflammatory and analgesic. Also -20 C Purity: 99% inhibits cyclooxygenase, PGH synthase-1 Essential intermediate of α and PGH synthase -2. 1 ,25-dihydroxyvitamin D3 biosynthesis. C13H18O2 MW 206.3 Also appears as a circulating metabolite of vitamin D3. Ref.: DeLuca, H.F., et.al., J. Clin. Invest., 48, 1273 (1969). MW 400.6

HYGROMYCIN B 250 KU 45.00 157513 [31282-04-9] 1 MU 143.55 RS-IBUPROFEN [3H(G)] 250 µCi 653.65 RT Purity: ≥ 85% 5 MU 627.65 26039 Sp. Act. 100-500 mCi/mmol 1 mCi 1575.35 Aqueous solution, approx. 450,000 0-5oC 3.70-18.5 TBq/mmol units/ml.C20H37N3O13 MW 527.5 Ethanol solution. C20H37N3O13 MW 527.5 Please call for delivery information. MW 206.3

HYPERICIN 1 mg 77.00 193423 [548-04-9] RT From Hypericum perforatum Purity: >85% Selective inhibitor of Protein Kinase C C30H16O8 MW 504.5 R(-)-IBUPROFEN [Carboxy-14C] 50 µCi 1211.55 16021 Sp. Act. 50-60 mCi/mmol 0-5oC 1.85-2.22 TBq/mmol Ethanol solution. Please call for delivery information. CH3CHCH2C6H4CH(CH3)CO2H HYPOTAURINE 100 mg 75.00 MW 206.3 159711 [300-84-5] 250 mg 150.00 RT (2-Aminoethylsulfinic acid) Crystalline C2H7NO2S MW 109.2

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ RS-IBUPROFEN [Carboxy-14C] 50 µCi 605.15 IMETIT 1 mg 14.25 16022 (4-Isobutyl-α-methylphenylacetic acid) 250 µCi 1575.35 193666 [102203-18-9] 5 mg 44.10 0-5oC Sp. Act. 50-60 mCi/mmol RT (S-[2-(Imidazol-4-yl)ethyl]isothiourea) 10 mg 79.40 1.85-2.22 TBq/mmol Dihydrobromide Ethanol solution. Potent, selective H3 histamine receptor Please call for delivery information. agonist. CH3CHCH2C6H4CH(CH3)CO2H C6H10N4S • 2HBr MW 332.1 MW 206.3 25 mg 24.25 14 µ IMIDAZOLE-4-ACETIC ACID S(+)-IBUPROFEN [Carboxy- C] 50 Ci 605.15 193667 [3251-69-2] 100 mg 72.75 16023 (4-Isobutyl-α-methylphenylacetic acid) o RT Hydrochloride 0-5 C Sp. Act. 50-60 mCi/mmol A GABAc antagonist. 1.85-2.22 TBq/mmol C5H6N2O2 • HCl MW 162.6 Ethanol solution. Please call for delivery information. 6-[2-(4-IMIDAZOYL)ETHYLAMINO]-N- 1 mg 18.95 CH3CHCH2C6H4CH(CH3)CO2H MW 206.3 159948 (4-TRIFLUOROMETHYLPHENYL)- 5 mg 73.35 RT HEPTANE CARBOXAMIDE ICE INHIBITOR 1 mg 98.00 (HTMT) 195865 (CPP32/Apopain Inhibitor; Ac-DEVD-CHO) Dimaleate Salt -20oC Ac-Asp-Glu-Val-Asp-CHO Purity: 98% Purity: ≥97% Receptor agonist to the histamine H1. Potent, specific and reversible Ref.: 1. Khan, M.M., et al., J. Immunol., CPP32/Apopain inhibitor. 137, 308 (1986). C20H30N4O11 MW 502.5 2. Qiu, R., et al., J. Pharmacol. Exp. Therap., 253, 1245 (1990). ICE INHIBITOR I 1 mg 89.25 MW 614.6 195870 [143313-51-3] 5 mg 273.00 o 5 -20 C (Ac-YVAD-CHO; Caspase Inhibitor I) N -(1-IMINOETHYL)-L-ORNITHINE 1 mg 22.85 Ac-Tyr-Val-Ala-Asp-CHO 193668 [36889-13-1] 5 mg 89.25 Purity: ≥97% RT (L-NIO) Inhibits Interleukin 1β Converting Enzyme Hydrochloride (ICE). Purity: ≥98% C24H32N4O9 MW 520.5 Powerful inhibitor of endothelial nitric oxide synthase. ICE INHIBITOR II 1 mg 110.25 C7H15N3O2 • 2HCl MW 246 195872 (Ac-YVAD-CMK) 5 mg 341.25 -20oC Ac-Tyr-Val-Ala-Asp-CMK ≥ 2-IMINOPIPERIDINE 1 mg 6.75 Purity: 97% 193669 Hydrochloride 5 mg 15.75 Biotinylated β RT A nitric oxide synthase inhibitor, with 25 mg 41.00 Inhibits Interleukin 1 Converting Enzyme selectivity for the inducible form (iNOS). (ICE) irreversibly. C5H10N2 • HCl MW 134.6 MW 724.3 3 µ ICE INHIBITOR III 1 mg 98.00 IMIPRAMINE [N-Methyl- H] 250 Ci 641.55 26040 Hydrochloride 1 mCi 1575.35 195873 Ac-Tyr-Val-Ala-Asp-Acyloxymethylketone o -20oC Purity: ≥90% 0-5 C Sp. Act. 70-90 Ci/mmol Selectively and strongly inhibits Interleukin 2.59-3.33 TBq/mmol 1β Converting Enzyme (ICE). Ethanol solution. MW 761.7 Please call for delivery information. MW 316.9 ICE SUBSTRATE 1 mg 79.00 195868 (CPP32/Apopain Substrate; IMIPRAMINE 5 g 14.65 -20oC Ac-DEVD-AMC) 190218 [113-52-0] 25 g 46.75 Ac-Asp-Glu-Val-Asp-AMC RT (10,11-Dihydro-N,N-dimethyl- 100 g 129.50 Purity: ≥97% dibenz[b,f]azepine-5- Fluorometric substrate for CPP32/Apopain propanamine) and related cysteine proteases. Hydrochloride C30H37N5O13 MW 675.6 Crystalline A serotonin uptake inhibitor. IFENPRODIL 5 mg 40.10 C19H24N2 • HCl MW 316.9 159785 [23210-56-2] 10 mg 71.65 o 0-5 C NMDA receptor antagonist. 25 mg 143.30 INDATRALINE 1 mg 12.50 Ref.: Graham, et al., Eur. J. Pharm., 226, 193671 [96850-13-4] 5 mg 47.40 373 (1992). 0-5oC Hydrochloride C21H27NO2 MW 325.4 Inhibitor of dopamine, norepinephrine and serotonin uptake. µ ILIMAQUINONE 100 g 138.85 C16H15NCl2 • HCl MW 328.7 159947 [71678-03-0] -20oC Purity: 99% Completely and reversibly induces the INDO 1 1 mg 87.25 152287 [132319-56-3] breakdown of Golgi membranes. Inhibits o β 0 C (1-[2-Amino-5-(6-carboxyindol- the association of -COP and ′ ADP-ribosylation factor to Golgi 2-yl)phenoxy]-2-(2 -amino- 5′-methylphenoxy)ethane- membranes. It does not induce the ′ ′ redistribution of Golgi membranes into the N,N,N ,N -tetraacetic acid) endoplasmic reticulum or the random fusion Pentasodium Salt of adjacent Golgi cisternae. Calcium chelator and indicator. Ref.: 1. Takizawa, P.A., et al., Cell, 73, 1 Unusually large shift in fluorescence (1993). emission from 480 nm to 400 nm makes 2. Veit, B., et al., J. Biol. Chem., 122, 1197 INDO 1 useful for spectrofluorometric (1993). determinations of calcium. MW 358.5 C32H26N3O12Na5 MW 759.6

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ INDO 1-AM 1 mg 104.95 D,L-myo-INOSITOL-1,4,5- 1 mg 273.00 152288 [112926-02-0] 195689 TRIPHOSPHOROTHIOATE o RT The acetoxymethyl ester of INDO 1. Able to -20 C (InsP3S3) permeate cell membranes, is then rapidly Hexatriethylamine Salt hydrolyzed by cytoplasmic esterases, Purity: 98% releasing INDO 1 inside the cell, where it IP3 analog which is resistant to metabolic remains trapped. enzymes, thus, has an extended duration of C47H51N3O22 MW 1009.9 action. It resists IP3 kinase and 5-phosphatase which it potently inhibits. (+)-INDOLACTAM V 1 mg 148.90 MW 694.3 159601 [90365-56-3] 0oC Purity: 99+% C17H23N3O2 MW 301.4 D-myo-INOSITOL 1,3,4- 100 µg 192.25 158352 TRISPHOSPHATE (IP3) (-)-INDOLACTAM V 1 mg 115.85 0-5oC [140385-74-6] 159602 [90365-57-4] o Hexapotassium Salt 0 C Purity: 99+% Ins(1,3,4)P3 Activates protein kinase C Synthetic 1 31 C17H23N3O2 MW 301.4 Purity: >99% as per H and P NMR. 20 [α]D = +13.6° (c = 2, pH 8.2) INDOMETHACIN 1 g 14.05 Ref: Rossier, M.F., et. al., (1986), Biochem. 190217 [53-86-1] 5 g 21.50 Biophys. Res. Commun., 139, 259. RT (1-[p-Chlorobenzoyl]-5-methoxy-2-methylindo 10 g 35.85 C6H9O15P3K6 MW 648.6 le-3-acetic acid) 25 g 64.90 Crystalline 100 g 170.45 Inhibitor of cyclooxygenase. D-myo-INOSITOL 1,4,5- 1 mg 156.50 C19H16ClNO4 MW 357.8 158354 TRISPHOSPHATE 0-5oC Tripotassium Salt INGENOL 1 mg 60.00 Ins (1,4,5)P 151325 [30220-46-3] 5 mg 238.95 3 o Synthetic 0 C A weak Protein Kinase C activator. Enantiomerically pure. Greater than 99% POSSIBLE CARCINOGEN! pure as per 1H and 31P NMR C20H28O5 MW 348.4 Functions as a second messenger in the release of calcium from intracellular scyllo-INOSITOL 1 mg 9.50 organelles; has been implicated as a 159603 [488-59-5] 5 mg 18.75 mediator of phototransduction in Limulus RT (Scyllitol) photoreceptors where it effects changes in C6H12O6 MW 180.2 ion permeability and sodium ion currents. Soluble in water. D-myo-INOSITOL 50 g 14.85 Ref: 1.Berridge, M.J. and Irvine, R.F., 102052 [87-89-8] 100 g 21.80 (1984), Nature, 312, 315. 2.Brown, J.E., et RT (i-Inositol; myo-Inositol; meso-Inositol) 500 g 78.40 al., (1984), Nature, 311, 160. 3. Grado, C. A lipotropic agent. 1 kg 141.25 and Ballou, C.E., (1961), J. Biol. Chem., C6H12O6 MW 180.2 236, 54. 4. Tomlinson, R.V. and Ballou, C.E., (1961), J. Biol. Chem., 236, 1902. 5. D-myo-INOSITOL 1,3,4,5- 1 mg 751.20 Brockerhoff, H. and Ballou, C.E., (1961), J. 158353 TETRAPHOSPHATE Biol. Chem., 236, 1907. 0-5oC [135269-51-1] Ins (1,3,4,5,)P4 Potassium Salt D-myo-INOSITOL 1,4,5- 1 mg 86.00 Synthetic 1 31 159606 TRISPHOSPHATE Purity: >99% as per H and P NMR. 0oC [112571-69-4] Enantiomerically pure. 20 Triammonium Salt [α]D = -3.6° (c= 5.5, pH 8.3) Purity: 99+% Ref:(1) Irvine, R.F., et. al., (1986), Nature, C6H12O15P3 • (NH4)3 MW 471.2 320, 631. (2)Hansen, C.A., et. al., (1986), J. Biol. Chem., 261, 8100. D-myo-INOSITOL-1,4,5- 100 µg 108.45 (3)Cerdan, S., et. al., (1986), J. Biol. 154602 TRISPHOSPHATE Chem., 261, 14676. 0oC [103476-24-0] (4)Higashida, H. and Brown, D.A., (1986), (L-α-Phosphatidylinositol 4,5-bisphosphate) FEBS, 208, 283. From Bovine Brain (5)Irvine, R.F. and Moor, R.M., (1986), Tripotassium Salt Biochem. J., 240, 917. Purity: ∼98% C6H8O18P4K8 MW 804.8 Contains less than 1% of the 2,4,5-isomer. Reported to stimulate selective and specific D-myo-INOSITOL-1,4,5- 1 mg 373.85 mobilization of intracellular calcium. 195687 TRIPHOSPHATE o Involved in cell growth and oncogenesis. 0 C [103476-24-0] Ref.: 1. Vacca, et al., J. Am. Chem. Soc., (IP3) 109, 3478 (1987). 2. Abdel-Latif, Hexapotassium Salt Pharmacol. Rev., 38, 227 (1986). 3. Purity: 99% Berridge, M.J. and Irvine, R.F., Nature, 312, Stimulates the release of calcium ions from 315 (1984). intracellular stores. MW 648.6 L-myo-INOSITOL 1,4,5- 1 mg 94.00 D-myo-INOSITOL-1,4,5- 1 mg 212.75 159607 TRISPHOSPHATE 195688 0oC o TRIPHOSPHATE [129828-71-3] 0 C [108340-81-4] Hexapotassium Salt (IP3) Purity: 99% Hexasodium Salt Unnatural enantiomer of IP3 Purity: 99% C6H9O15P3K6 MW 648.6 MW 552.0

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ β3-INTEGRIN 10 µg 83.95 IONOMYCIN 1 mg 126.10 693231 MONOCLONAL ANTIBODY 159611 [56092-81-0] 0-5oC Anti-Human 0-5oC Free Acid Clone: BB10 Purity: 90+% Isotype: mouse IgG1 presented affinity Selective calcium ionophore purified C41H72O9 MW 709.0 Conc/Titer: 1 µg/10 µl Applications: Immunohistochemistry; IONOMYCIN 1 mg 60.00 Immunoblotting 155070 [56092-82-1] 5 mg 240.00 The original immunogen was a partially 0-5oC Calcium Salt purified platelet glycoprotein IIb/IIIa From Streptomyces conglobatus complex. The antibody reacts with A polyether ionic antibiotic that exhibits an beta-3-integrin including the GPIIIa of affinity for Ca2+. platelets. Ref.: Toeplitz, B.K., et al., J. Am. Chem. Soc., 101, 3344 (1979). m-IODOBENZYLGUANIDINE 1 mg 25.00 U.S. Patent No. 3,873,693. 159949 [80663-95-2] 5 mg 105.00 C41H70O9Ca MW 747.1 -20oC (MIBG) Hemisulfate Salt Purity: 98% IPRATROPIUM BROMIDE 25 mg 31.80 Arginine specific 153682 [22254-24-6] 50 mg 56.40 mono-ADP-ribosyltransferase competitive RT (3-(3-Hydroxy-1-oxo-2-phenyl- 100 mg 101.25 inhibitor. Antitumor agent which prevents propoxy)-8-methyl-8-(1-methyl- ADP-ribosylation-dependent signal ethyl)-8-azoniabicyclo[3.2.1]- transduction pathways. octane bromide) Ref.: 1. Smets, L.A., et al., Biochim. Anticholoinergic Biophys. Acta, 1054, 49 (1990). C20H30BrNO3 MW 412.4 2. Loesberg, C., et al., Biochim. Biophys. Acta, 1037, 92 (1990). IPRONIAZID PHOSPHATE 250 mg 10.90 3. Halldorsson, H., et al., FEBS Lett., 314, 153538 [305-33-9] 1 g 21.75 322 (1992). o • 0-5 C Crystalline C8H10IN3 1/2H2SO4 MW 324.1 Monoamine Oxidase inhibitor C9H13N3O • H3PO4 MW 277.2 p-IODOCLONIDINE 5 mg 25.35 153686 [108294-53-7] 10 mg 43.35 RT (2-[(2,6-Dichloro-4-iodophenyl)imino]- 25 mg 86.75 3-ISOBUTYL-1-METHYLXANTHINE 100 mg 15.00 195262 [28822-58-4] 250 mg 30.00 imidazoline) o Hydrochloride 0 C (IBMX) 1 g 83.00 An α2-adrenergic agonist. Crystalline 5 g 330.00 C9H8Cl2N3I • HCl MW 392.5 Inhibits cyclic-AMP phosphodiesterase. Ref.: 1. Beavo, J.A., et al., Molec. 2-IODOMELATONIN 5 mg 27.55 Pharmacol., 6, 597 (1970); 2. Montague, W. 193673 [93515-00-5] 25 mg 110.25 and 0-5oC A melatonin agonist. Cook, J.R., Biochem. J., 122, 115 (1971). C10H14N4O2 MW 222.2 C13H15N2O2I MW 358.2 1-(5-IODONAPHTHALENE-1- 5 mg 48.00 ISOGUVACINE 5 mg 17.35 158937 153685 [64603-90-3] 10 mg 28.85 o SULFONYL)-1H-HEXAHYDRO-1,4- o 0 C DIAZEPINE 0-5 C Hydrochloride 25 mg 57.80 [110448-33-4] GABA agonist (ML-7) C6H9NO2 • HCl MW 163.6 Hydrochloride Purity: 99% ISONIPECOTIC ACID 10 g 20.00 Strongly and specifically inhibits MLC 151362 [498-94-2] 25 g 40.00 kinase. RT (Hexahydroisonicotinic acid) 100 g 120.00 Ref.: Saitoh, M., et.al., J. Biol. Chem., 262, Crystalline 7796 (1987). • Purity: 99% C15H17N2O2IS HCl MW 452.7 GABA agonist C6H11NO2 MW 129.2 1-(4-IODOPHENYL)-3-(2- 10 mg 135.00 158938 ADAMANTYL)GUANIDINE 50 mg 562.50 RT Purity: 99% ISOPROPYLAMINE bis(NITRIC 5 mg 26.45 193675 OXIDE) ADDUCT 25 mg 101.45 σ-receptor antagonist. o Ref.: Wilson, A.A., et.al., J. Med. Chem., 0-5 C Releases Nitric Oxide (NO) into aqueous 34, 1867 (1991). solutions. C12H30N4O2 MW 262.4 5-IODOTUBERCIDIN 1 mg 75.00 153683 [24386-93-4] 5 mg 345.00 DL 5 g 50.00 o -ISOPROTERENOL 0-5 C (ITU; 4-Amino-5-iodo-7-(β-D-ribo- 151368 [51-30-9] 25 g 150.00 furanosyl)pyrrolo[2,3-d]- RT (Isopropylarterenol) pyrimidine) Hydrochloride Purity: ≥98% Crystalline Adenosine kinase inhibitor. A Bronchodilator C11H13IN4O4 MW 392.2 C11H17NO3 • HCl MW 247.7

3-IODO-L-TYROSINE 1 g 20.50 100 mg 11.00 155069 [70-78-0] 5 g 69.00 L-(-)-ISOPROTERENOL D-(+)- o 151366 500 mg 34.50 0 C (3-Monoiodo-L-tyrosine) BITARTRATE Crystalline RT [54750-10-6] Purity: ∼97% Dihydrate May contain up to 3% tyrosine. Crystalline C11H17NO3 • C4H6O6 • H2O MW 379.3 C9H10INO3 MW 307.1

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 1-(5-ISOQUINOLINE- 10 mg 133.05 -J- 158939 SULFONYL)-HOMOPIPERAZINE 25 mg 315.30 0oC [103745-39-7] 50 mg 604.85 JOSAMYCIN 50 mg 14.05 151380 [16846-24-5] 500 mg 104.95 (HA-1077) o B Dihydrochloride 0-5 C (Leucomycin V,3-aceta 4 -(3-methyl 1 g 201.80 Purity: 98% butanoate)) Specific inhibitor of PKA and PKG. Potent (Leucomycin A3) vasodilator. From Streptomyces narbonensis Ref.: 1. Asano, T., et.al., Br. J. Pharmacol., m.p. 130-133°C 98, 1091 (1989). 2. Sasaki, Y. and Sasaki, Macrolide antibiotic Y., Biochem. Biophys. Res. Commun., 171, Ref.: K.C. Nicolau, et al., J. Am. Chem. 1182 (1990). 3. Asano, T., et.al., J. Soc., 103, 1,222 (1981). Pharmacol. Exp. Ther., 241, 1033 (1987). MW 828.0 C14H17N3O2S • 2HCl MW 364.3 -K- 5 mg 48.00 1-(5-ISOQUINOLINE- K-252a 100 µg 206.35 158940 SULFONYL)-2-METHYLPIPERAZINE 25 mg 188.00 o 158942 [97161-97-2] 1 mg 814.05 0 100 mg 595.00 o C [108930-17-2] 0 C Purity: 99% (H-7) Inhibitor of PKA, PKG, MLCK, CaMK, and Dihydrochloride phosphorylase kinase. Purity: 99% Ref.: 1.Kase, H., et.al., Biochem. Biophys. Inhibitor of PKA, PKG, MLCK, and protein Res. Commun., 165, 1207 (1989). 2. kinase C. Yamada, K., et.al., ibid., 144, 35 (1987). 3. Ref.: Hidaka, H., et.al., Biochemistry, 23, Hashimoto, Y., et.al., ibid., 181, 423 (1991). 5036 (1984). • 4. Elliot, L.H., et.al., ibid., 171, 148 (1990). C14H17N3O2S 2HCl MW 364.3 MW467.5 1-(5-ISOQUINOLINESULFONYL)-3- 5 mg 48.00 K-252b 100 µg 206.35 159612 25 mg 188.00 158943 [99570-78-2] 250 µg 412.70 METHYLPIPERAZINE o 0-5oC [140663-38-3] 0 C Purity: 99% (Iso-H7) Inhibitor of PKA, PKG, MLCK, and PKC. Dihydrochloride Ref.: Kase, H., et.al., Biochem. Biophys. Purity: 99% Res. Commun., 142, 436 (1987). Isomer of H7 [see MW 453.5 1-(5-Isoguinolinesulfonyl)-2-methylpiperazine ] which exhibits inhibition of PKC. KAINIC ACID 100 mg 42.00 C H N O S • 2HCl MW 364.3 195264 [487-79-6] 500 mg 178.50 14 17 3 2 RT (2-Carboxyl-3-carboxymethyl-4-isopropenylp 1 g 309.75 yrrolidine) 1-(5-ISOQUINOLINESULFONYL)- 5 mg 32.00 Crystalline 159613 25 mg 125.00 o PIPERAZINE A minor amino acid found in Digenea 0 C [84468-24-6] simplex seaweed. (HA-100) C10H15NO4 MW 213.2 Dihydrochloride Purity: 99% KEMPTIDE 1 mg 41.45 Inhibits myosin light-chain kinase. 151389 [65189-71-1] 5 mg 127.50 o C13H15N3O2S • 2HCl MW 350.2 -20-0 C (Phosphate Acceptor Peptide; 10 mg 229.70 Leu-Arg-Arg-Ala-Ser-Leu-Gly) 25 mg 459.40 ISOTETRANDINE 1 mg 45.30 Ref.: Kemp, B.E., et al., Fed. Proc., 35, 159950 Purity: 98% 5 mg 200.65 1384 (1976). o -20 C Biscoclaurine alkaloid which inhibits the [Trp4]-KEMPTIDE 1 mg 80.25 activation of phospholipase A2 by G protein. 159614 [80224-16-4] It does not inhibit the G protein activation of o 0 C Leu-Arg-Arg-Trp-Ser-Leu-Gly phospholipase C or D. Substrate for cAMP-dependent protein Ref.: 1. Akiba, S., et al., Biochem. kinase. Pharmacol., 44, 45 (1992). Ref.: Wright, D.E., et al., Proc. Nat. Acad. 2. Hashizume, T., et al., Biochem. Scr. USA, , 6048 (1981) Pharmacol., 41, 419 (1991). 78 MW 622.8 KETAMINE 100 mg 12.00 153681 [6740-88-1] 1 g 24.00 ISOTOCIN 0.5 mg 59.45 RT (2-(2-Chlorophenyl)methyl- 151373 [550-21-0] 1 mg 91.70 amino)cyclohexanone) o -20-0 C (Cys-Tyr-Ile-Ser-Asn-Cys-Pro-Ile-Gly-NH2) Hydrochloride Contains Cys1-Cys6 disulfide bond. NMDA antagonist Ref: Guttman, S., et al., Experentia, 18, C13H16ClNO • HCl MW 274.2 445 (1962). C41H63N11O12S2 MW 966.1 KETANSERIN TARTRATE 10 mg 28.00 153680 [83846-83-7] 25 mg 55.00 o ISOXANTHOPTERIN 10 mg 15.00 0-5 C (3-[2-(4-Fluorobenzoyl)-1-piperdinyl]-ethyl]-2, 50 mg 99.00 153687 [529-69-1] 25 mg 30.00 4(1H,3H)-quinazolinedione tartrate) Blocks 5-HT2 serotonin receptors. RT C6H5N5O2 MW 179.1 C22H22FN3O3 • C4H6O6 MW 545.5 IVERMECTIN 250 mg 10.50 KETOCONAZOLE 50 mg 28.65 196009 [70288-86-7] 1 g 30.00 159158 [65277-42-1] 100 mg 48.70 o 0-5 C (22,23-Dihydroavermectin B1) RT Purity: 99% 500 mg 212.10 Purity: ≥95% Cytochrome P450 inhibitor and 1 g 350.00 Antiparasitic and macrolide antiobiotic. demonstrates anti-psoriatic activity Semisynthetic derivative of avermectin B1a Ref.: 1. Lambert, A., et.al., Biochem. and B1b. Pharmacol., 35, 3999 (1986). 2. Van C48H74O14S MW 875.1 Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989). 3. Tucker, W.F.G., et.al., Br. Med. J., 293, 882 (1986). C26H28N4O4Cl2 MW 531.4

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ KETOTIFEN 250 mg 28.00 KT 5926 100 µg 172.00 155155 [34580-14-8] 500 mg 42.00 158947 [126643-38-7] 1 mg 1310.00 RT Fumarate Salt 1 g 68.00 0oC Purity: 98% An H1 Histamine receptor antagonist that Propylether derivative of K-252a which inhibits the anaphylactic release of inhibits multiple kinases being most specific histamine. for CaM Kinase II. C19H19NOS • C4H4O4 MW 425.5 Ref.: 1. Kase, H., et.al., Biochem. Biophys. Res. Commun., 142, 436 (1987). 2. Hashimoto, Y., et.al., ibid., 181, 423 (1991). KIFUNENSINE 1 mg 342.80 3. Nakanishi, S., et.al., Mol. Pharmacol., 37, 159952 [109944-15-2] o 482 (1990. -20 C Purity: 98% MW 525.5 Immunomodulator which inhibits α-mannosidase and asparagine-linked KYNURENIC ACID 250 mg 6.25 oligosaccharide processing. 102124 [492-27-3] 1 g 16.50 Ref.: 1. Iwami, M., et al., J. Antibiot., 40, RT (4-Hydroxyquinoline-2-carboxylic acid) 5 g 75.90 612 (1987). Crystalline 2. Chandrosekaran, S., et al., J. Biol. C10H7NO3 MW 189.2 Chem., 269, 3356 (1994). MW 232.2 KYOTORPHIN 10 mg 7.65 195268 [70904-56-2] 250 mg 100.00 -20-0oC (Tyr-Arg) KINETENSIN 1 mg 31.85 When administered intracisternally to mice, 154464 [103131-69-7] o this dipeptide has about 4.2-fold more 0-5 C H2N-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH analgesic potency than met-enkephalin; it promotes the release of met-enkephalin. Neurotensin-related peptide which Ref. 1. Fournie-Zaluski, M.C., et al., increases vascular permeability and Biochem. Biophys. Res. Commun., 91, 130 releases histamine from rat mast cells. (1979). Ref.: Carraway, R.E., et al., (1987), JBC, 2. Takagi, H., et al., Nature, 282, 410 (1979). 262, 5968 MW 1172.5 -L- KN-62 1 mg 78.10 L-655,238 158944 [127191-97-3] 5 mg 350.00 α 0oC (1-(N,O-bis-[5-isoquinolinesulfonyl]-N-methyl See: -Pentyl-4-(2-quinolinylmethoxy)benzenemethanol -L-tyrosyl)-4-phenyl-piperazine) µ Purity: 98% LACTACYSTIN 200 g 291.20 195863 Synthetic Potently and specifically inhibits o Ca2+/calmodulin kinase II. -20 C Cell permeable 20S proteasome inhibitor. Ref.: Tokumitsu, H., et.al., J. Biol. Chem., Induces neurite outgrowth in mouse 265, 4315 (1990). neuroblastoma cells and inhibits C38H35N5O6S2 MW 721.8 progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G1 phase. Appears to induce KN-93 250 µg 52.50 apoptosis in human monoblast cells. 196012 [139298-40-1] 1 mg 147.00 C15H24N2O7S MW 376.4 0-5oC (N-[2-(N-(4-Chlorocinnamyl)-N-methylaminom ethyl)phenyl]-N-[2-hydroxyethyl]-4-methoxybe β-LAPACHONE 1 mg 26.25 nzenesulfonamide) 196031 [4707-32-8] 5 mg 99.75 Purity: ≥95% -20oC Purity: ≥98% 25 mg 367.50 Selective Ca++/calmodulin-dependent Novel DNA topoisomerase I inhibitor. protein kinase II inhibitor. Induces G1 cell MW 242.3 cycle arrest and apoptosis in NIH 3T3 cells. α µ C26H29ClN2O4S MW 501.0 α-LATROTOXIN 40 g 716.60 193961 From Latrodectus tredecemguttatus -20oC The principal protein component of black KOJIC AMINE 25 mg 52.00 Widow spider venom which causes 153679 [68642-64-8] 50 mg 99.05 massive neurotransmitter release from a RT (2-(Aminomethyl)-5-hydroxy-4H-pyran-4-one 100 mg 187.95 variety of central and peripheral synaptic )Hydrobromide junctions. It is useful in synaptic vesicle GABA receptor agonist. • exocytosis studies of numerous C6H7NO3 HBR MW 222.0 neurotransmitters. Ref.: Frontali, J. Cell. Biol., 68, 462 (1976). KT 5720 100 µg 172.00 MW 130 kDa 158945 [108068-98-0] 1 mg 991.85 o 100 µg 56.00 0 C Purity: 98% LATRUNCULIN B 159800 A unique marine toxin found in Red Sea 1 mg 175.00 Hexylester derivative of K-252a which o specifically inhibits PKA. 0-5 C sponge. Acts as an inhibitor of actin Ref.: 1. Kase, H., et.al., Biochem. Biophys. polymerization. More potent toxin than the Res. Commun., 142, 436 (1987). 2. Cytochalasins. Yamada, K. and Ishii, A., Jpn. J. MW 395.5 Pharmacol., 49, 263P (1989). LAVENDUSTIN A 1 mg 90.20 MW 537.6 158815 [125697-92-9] 5 mg 360.40 0oC Lavendustin A is a potent and selective µ inhibitor of the EGF receptor tyrosine KT 5823 100 g 172.00 1 158946 [126643-37-6] kinase (IC50=11 nM) . It binds to a site on o the kinase which is distinct from the ATP 0 C Purity: 98% 2 Derivative of K-252a and specifically and peptide substrate binding sites . inhibits PKG. Ref: 1.Onada, T., et al., (1989), J. Nat. Ref.: Kase, H., et.al., Biochem. Biophys. Prod., 52, 1252. Res. Commun., 142, 436 (1987). 2. Hsu, C.-Y.J., et al., (1991), J. Biol. MW 495.5 Chem., 266, 21105. C21H19NO6 MW 381.4

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $

LAVENDUSTIN B 1 mg 94.65 LIPOXIN B4 25 µg 169.00 159615 [125697-91-8] 159177 [98049-69-5] 0oC (N,N-bis(2′-Hydroxybenzyl)-3-aminosalicylic -70oC [5(S), 14(R), acid) 15(S)-Trihydroxyeicosa-6E,8Z,10E,12E-tetra Purity: 95-97% enoic acid] Tyrosine kinase inhibitor. May also be used Purity: >99% as a negative control for Lavendustin A. 25µg/ml ethanol C21H19NO5 MW 365.4 C20H32O5 MW 352.5

µ 5-LIPOXYGENASE 1 mg 1261.25 LETHAL TOXIN INHIBITING FACTOR 10 g 17.20 159178 From Potato 159835 (LTIF) 50 µg 78.00 o o -70 C Purity: 98% 0-5 C From Opossum Serum Activity: w/linoleic acid- 24 units/mg (Didelphis virginiana) protein, w/arachidonic acid- 8 units/mg Purified. protein. Single band by SDS-PAGE. Unit Definition: One unit consumes one Shown to inhibit the lethality of various µmole of O2 per minute at 30°C. venoms and toxins. Also acts as histamine Supplied in 2M ammonium sulfate and blocker when tested on mast cells. As little µ 0.15M potassium phosphate at pH 6.3. as 0.5 g LTIF, when mixed with normally Ref.: Reddanna, P., et.al., Methods lethal doses of various venoms or toxins, Enzymol., 187, 268 (1990). inhibits the lethality of the venom injected IP in mice. 12-LIPOXYGENASE 100 U 338.25 MW 66 kDa 159179 From Porcine Leukocytes -70oC Activity: ∼50 units/mg protein. LEUPEPTIN 0.5 mg 9.00 Unit Definition: One unit will convert one 151553 [103476-89-7] 1 mg 11.50 nanomole of arachidonic acid to 12-HPETE -20-0oC (Acetyl-Leu-Leu-Arg-al) 5 mg 45.00 per minute at 20°C. Hemisulfate 25 mg 90.00 Supplied in 20mM Tris-HCl, 0.5mM EDTA, Inhibitor for trypsin, plasmin, papain, and 100 mg 265.05 PMSF, and DTT at pH 7.2. cathepsin B. Ref.: Yokoyama, C., et.al., J. Biol. Chem., Ref: Kondo, S., et al., Chem. Pharm. Bull., 261, 16714 (1986). 17, 1869 (1969). C H N O • 1/2H SO MW 475.6 15-LIPOXYGENASE 5 KU 515.95 20 38 6 4 2 4 159180 From Rabbit Reticulocytes -70oC Activity: ∼8 KU/mg protein. LEUPEPTIN 1 mg 13.65 Unit Definition: One unit will convert one 195623 [147385-61-3] 5 mg 47.25 o nanomole of linoleic acid per minute at 0 C (Acetyl-Leu-Leu-Arg-al) 25 mg 211.50 20°C. Trifluoroacetate Salt ≥ Supplied in 10mM potassium phosphate Purity: ≥90% buffer at pH 6.3. Inhibitor for trypsin, plasmin, papain, and Ref.: 1. Bryant, R.W., et.al., ibid., 257, 6050 cathepsin B. • (1982). 2. Schewe, T., et.al., Methods C20H38N6O4 C2HF3O2 MW 540.6 Enzymol., 71, 430 (1981). 3. Kuhn, H., et.al., J. Biol. Chem., 265, 18351 (1990). LEUPEPTIN 1 mg 10.00 195624 [24125-16-4] 5 mg 25.60 R-(+)-LISURIDE 5 mg 17.65 0-5oC (Acetyl-Leu-Leu-Arg-al) 25 mg 83.95 193677 [19875-60-6] 25 mg 70.55 Hydrochloride 100 mg 245.20 RT Hydrogen Maleate Purity: ≥60% D2 Dopamine agonist and a serotonin mixed receptor agonist/antagonist. Protease inhibitor. • C20H38N6O4 • HCl MW 463.0 C20H26N4O C4H4O4 MW 454.5 S-(-)-LISURIDE 5 mg 17.65 LEVAMISOLE 5 g 16.45 193678 [140387-89-9] 25 mg 70.55 155228 [16595-80-5] 10 g 27.35 RT Exhibits action as a D2 dopamine receptor RT (L[-]-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b agonist and D1 dopamine receptor ]thiazole) antagonist. Also an α- and β-adrenoceptor Hydrochloride antagonist. Crystalline C20H26N4O MW 338.4 Suitable as an inhibitor of various mammalian alkaline phosphatases. LOMOFUNGIN 5 mg 53.80 Intestinal alkaline phosphatases are only 158949 [26786-84-5] 10 mg 98.40 slightly inhibited. 0-5oC (U- 24792) 25 mg 225.75 Ref.: Van Belle, H., Biochim. Biophys. Purity: 98% 50 mg 410.95 Acta., 289, 158 (1972). Broad spectrum antibiotic. Also, inhibits C11H12N2S • HCl MW 240.8 RNA synthesis. Ref.: Kopecka, M. and Farkas, V., J. Gen. Microbiol., 110, 453 (1979). LEVETIMIDE 1 mg 13.50 151554 Hydrochloride 5 mg 25.45 o LOPERAMIDE 1 g 22.95 0 C Reported useful as a receptor in 10 mg 47.05 153676 [34552-83-5] 5 g 70.00 neurobiochemical research 25 mg 87.50 RT (4-(4-chlorophenyl)-4-hydroxy- • C23H26N2O2 HCl MW 398.9 N,N-dimethyl-α,α-diphenyl- 1-piperidine butanamide) LINCOMYCIN 1 g 22.35 Hydrochloride 158948 [859-18-7] 5 g 106.40 Calcium channel antagonist o 0-5 C (U-10149A) C29H33CIN2O2 • HCl MW 513.5 Purity: 98% Hydrochloride LORGLUMIDE 25 mg 41.90 Active against gram-positive bacteria. Binds 193679 [97964-56-2] 100 mg 147.75 to the 50S subunit of bacterial ribosomes RT Sodium Salt and suppresses protein synthesis. A potent, selective non-peptide cholecystokinin receptor antagonist. C18H34N2O6S • HCl MW 443 C22H31N2O4Cl2Na MW 481.4

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ LUBROL 100 g 39.80 195299 This compound is composed of ethylene 250 g 79.55 -M- RT oxide condensates of fatty alcohols. Used MAITOTOXIN 5 µg 154.75 for dissolving membrane-bound 158950 [59392-53-9] 10 µg 280.90 o adenylcyclase. -20-0 C Purity: ≥95% 25 µg 676.50 Ref.: Levey, G,S., Biochem. Biophys. Activates L-type Ca2+ channels and Comm., 38, 86 (1970). stimulates phosphoinositide turnover isolated from marine dinoflagellates. Ref.: 1. Choi, O.H., et.al., Mol. Pharmacol., LUCIFERASE 1 mg 110.25 37, 222 (1990). 2. Yokoyama, A., et.al., 195779 Firefly, Recombinant Biochem., 104, 184 (1988). 3. Gusovsky, F. -20oC Crystalline ≥ and Daly, J.W., Biochem. Pharmacol., 39, Purity: ≥95% 1633 (1990). Activity: 30 units/mg C164H256O68S2Na2 MW 3422 Unit Definition: one unit will release 1 nM of pyrophosphate from ATP per minute at MALANTIDE 500 µg 89.00 25°C in the presence of 540 µM ATP, 0.1 159801 (cAMP-Dependent Protein Kinase 1 mg 138.25 mM d-luciferin and 5 mM magnesium 0-5oC Substrate) sulfate. Arg-Thr-Lys-Arg-Ser-Gly-Ser-Val-Tyr-Glu-Pro -Leu-Lys-Ile Very potent Protein Kinase substrate. LUCIFER YELLOW CH 1 mg 10.90 MW 1634.1 155267 [67769-47-5] 10 mg 49.30 0-5oC Dilithium Salt 25 mg 100.30 MANGANESE (III) tetrakis-(4-BENZOIC 1 mg 10.50 A highly fluorescent dye. 100 mg 358.00 196048 ACID)PORPHYRIN 5 mg 23.10 Useful in marking nerve cells. 0-5oC (MnTBAP) 25 mg 78.75 Ref.: Stewart, W., Cell, 14, 741 (1978). Purity: ≥95% C13H9N5O9S2Li2 MW 457.2 Cell permeable SOD mimetic and a selective peroxynitrite scavenger. It is NOT a nitric oxide scavenger. LUCIFER YELLOW CH 1 mg 50.00 Ref.: Faulkner, K.M., et al., Jour. of Biol. 155266 [71206-95-6] 10 mg 135.00 o Act., 269(38), 23471-23476 (1994). 0-5 C Dipotassium Salt 25 mg 242.00 C H MnN O MW 845.7 A highly fluorescent dye. 48 30 4 8 Useful in marking nerve cells. MANGANESE (III) tetrakis-(1-METHYL- 1 mg 10.50 Ref.: Stewart, W., Cell, 14, 741 (1978). 196049 5 mg 23.10 o 4-PYRIDYL)PORPHYRIN C13H9N5O9S2K2 MW 521.6 0-5 C (MnTMPyP) 25 mg 109.00 Purity: ≥95% Cell permeable SOD mimetic. Catalyzes LUFFARIELLOLIDE 1 mg 228.15 - 159017 From Luffariella sp. the dismutation of O2 in the presence of -20oC Purity: 98% excess EDTA. Related structurally to manoalide. Ref.: Faulkner, K.M., et al., Jour. of Biol. Act., 269(38), 23471-23476 (1994). Phospholipase A2 inhibitor which is partially reversible and less potent than manoalide. C44H42MnN8 MW 737.8 Ref.: Albizati, K.F., et.al., Experentia, 43, MANOALIDE 1 mg 228.15 949 (1987). 158951 From Luffariella variabilis MW 386.3 -20-0oC Purity: ≥95% Phospholipase A2 and C inhibitor. Also LUZINDOLE 5 mg 46.50 blocks the release of arachidonate and 193680 (N-Acetyl-2-benzyltryptamine) 10 mg 89.70 inhibits calcium channels. -20oC A melatonin antagonist with high selectivity Ref.: 1. Jacobson, P.B., et.al., Biochem. for melatonin sites in mammalian CNS. Pharmacol., 39, 1557 (1990). 2. Wheeler, Soluble in ethanol. L.A., et.al., J. Biol. Chem., 262, 6531 C H N O MW 292.4 (1987). 3. Glaser, K.B. and Jacobs, R.S., 19 20 2 ibid., 36, 2079 (1987). 4. Lombardo, D. and Dennis, E.A., J. Biol. Chem., 260, 7234 LY 83583 (1985). 5. Mayer, A.M.S., et.al., J. Pharm. Exp. Ther., 244, 871 (1988). 6. Bennertt, C., See: 6-Anilino-5,8-quinolinedione et.al., Pharmacologist, 28, 538 (1986) C25H36O5 MW 416.5 LY 171883 10 mg 75.00 MAP-II KINASE 100 µg 750.00 159181 Purity: 98% 25 mg 153.00 692001 ANTIBODY RT Orally active, specific antagonist of -20oC Anti-Human leukotriene D4. Clone: MK12 Ref.: Fleisch, J.H., et.al., J. Pharmacol. Isotype: mouse IgG2b Exp. Ther., 233, 148 (1985). Conc/Titer: 1:5000 MW 318.4 Applications: immunoblotting; immunohistology; immunofluorescence α This 42 kDa serine/threonine kinase is L- -LYSOPHOSPHATIDYL- 5 mg 73.35 tyrosine phosphorylated upon stimulation of 159182 γ 10 mg 120.40 o CHOLINE- -O-HEXADECYL cells with EGF, PDGF or insulin. Enzyme -20 C [52691-62-0] 25 mg 270.60 activity is dramatically increased upon (Lyso-PAF c16; tyrosine phosphorylation. 1-o-Hexadecyl-sn-glycero-3-phosphorylcholin A synthetic peptide corresponding to e) positions 325-345 of the intact MAP kinase Purity: 99% was used as the immunogen to produce Inactive PAF metabolite. this antibody. This antibody demonstrates Ref.: Wykle, R.L., et.al., Biochem. Biophys. other species reactivity with dog, rat, Res. Commun., 100, 1651 (1981). mouse, chicken and frog. C24H52NO6P MW 481.7 Ref.: 1. Ray, L.B. and Sturgill, T.W., Proc. Nat. Acad. Sci. USA, 84, 1502-1506(1987). 2. Rossomando, A.J., et al., Proc. Nat. Acad. Sci. USA, 86, 6940-6943 (1989).

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ MARGATOXIN 5 µg 204.75 MECAMYLAMINE 1 mg 17.35 196017 (MgTx) 153675 [60-40-2] 5 mg 54.95 -20oC From Centruroides margaritatus RT Hydrochloride 10 mg 101.25 Purity: ≥98% Blocks action of nicotinic acid. Voltage dependent potassium ion channel C11H21N • HCl MW 203.8 blocker specific for Kv1.3 channel. MW 4179 MECLOFENAMIC ACID 1 g 14.50 159183 [6385-02-0] 5 g 48.00 MAS 7 1 mg 143.30 RT (Meclofenamate sodium; 10 g 89.00 159023 (Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Ly o 2-[(2,6-Dichloro-3-methylphenyl)-amino]benz -20 C s-Ala-Leu-Leu-NH2) oic acid) Purity: 98% Sodium Salt An analog of mastoparan with greater Purity: 99% potency. Inhibits 5-lipoxygenase and Ref.: Higashijima, T., et.al., J. Biol. Chem., cyclooxygenase. 265, 14176 (1990) Ref.: Columbo, M., et.al., Biochem. MW 1635.9 Pharmacol., 39, 285 (1990). C14H10Cl2NO2Na MW 318.1 MAST CELL DEGRANULATING 100 µg 92.00 154446 PEPTIDE o 8.00 0-5 C [83856-13-7] MELATONIN 100 mg (MCD) 102254 [73-31-4] 1 g 32.00 0oC (N-Acetyl-5-Methoxytryptamine) 5 g 138.00 H2N-Ile-Lys-Cys-Asn-Cys-Lys-Arg- His-Val-Ile-Lys-Pro-His-Ile- Crystalline 10 g 248.00 Cys-Arg-Lys-Ile-Cys-Gly-Lys- A hormone of the pineal gland. C13H16N2O2 MW 232.3 Asn-NH2 Ref.: Taylor, J. W., et al., (1984), J. Biol. Chem., 259, 13957; Bidard, J.N., et al., MELATONIN ELISA KIT 1 each 595.00 (1987), Brain Res., 418, 235 193596 The Melatonin ELISA is a competitive MW 2587.6 0-5oC enzyme immunoassay for the quantitative determination of melatonin in serum without MASTOPARAN X 1 mg 143.30 extraction. For melatonin measurement in 159024 (Ile-Asn-Trp-Lys-Gly-Ile-Ala-Ala-Met-Ala-Lys- serum, the samples are treated o -20 C Lys-Leu-NH2) enzymatically to free the antigen from its Purity: 98% binding proteins. The assay procedure Demonstrates similar action as mastoparan. follows the basic principle of competitive Ref.: Higashijima, T., et.al., J. Biol. Chem., ELISA whereby there is competition 265, 14176 (1990). between a biotinylated and non-biotinylated MW 1555.9 antigen for a fixed number of antibody binding sites. The kit is a 12 x 8 well format. MATRIX METALLOPROTEINASE-1 1 mg 52.50 196019 SUBSTRATE FOR RESEARCH USE ONLY! -20oC (MMP-1 Substrate; DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg; MELATONIN SULFATE ELISA KIT 1 each 575.00 Fibroblast Collagenase Substrate) 193597 (6-Sulfatoxymelatonin ELISA) Purity: ≥95% 0-5oC The 6-Sulfatoxymelatonin ELISA kit Fluorogenic substrate for human fibroblast provides materials for the quantitative collagenase. Soluble in 0.1% aqueous TFA. measurement of melatonin sulfate in urine. Km = 130 µM. The assay procedure follows the basic Excitation max.: 280 nm; Emission max.: principle of competitive ELISA: the 360 nm. competition between melatonin sulfate C46H65N13O12 MW MW 992.1 conjugated to horseradish peroxidase and melatonin sulfate in the sample for a fixed MATRIX METALLOPROTEINASES-2,7 1 mg 294.00 number of antibody binding sites. The kit is 196020 SUBSTRATE a 12 x 8 well format. -20oC (MMP-2/MMP-7 Substrate; MCA) MCA-Pro-Leu-Gly-Leu-DPA-Ala-Arg-NH2) FOR RESEARCH USE ONLY! Purity: ≥98% Sensitive fluorogenic substrate for MMPs. 250 mg 65.25 • MELENGESTROL ACETATE C49H68N14O15 C2H4O2 MW 1153.2 158952 [2919-66-6] 500 mg 123.80 RT (U-21240) 1 g 237.35 MATRIX METALLOPROTEINASES-2,9 1 mg 52.50 Purity: 99% 196021 SUBSTRATE o An antineoplastic agent. -20 C (MMP-2/MMP-9 Substrate; MW 396.5 DNP-Pro-Leu-Gly-Met-Trp-Ser-Arg; Fibroblast and Neutrophil Gelatinase 1 mg 26.20 Substrate) MELITTIN 102257 [37231-28-0] 5 mg 71.85 Purity: ≥95% o Fluorogenic substrate. 0 C Lyophilized. 10 mg 128.85 Purity: ∼85% C44H61N13O13S MW 1012.1 Hemolytic principle of bee venom; 1 mg 30.00 Activity: One part hemolyzes 5,000 parts MATRIX METALLOPROTEINASE blood. 196018 INHIBITOR I 5 mg 120.00 o MW 2846.5 -20 C (MMP Inhibitor I; 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH) Purity: ≥98% MEMANTINE 10 mg 25.20 Human matrix metalloproteinse inhibitor. 193681 [19982-08-2] 50 mg 89.25 C23H34N6O6 MW 490.6 RT (3,5-Dimethyladamantan-1-amine) Hydrochloride MECA 5 mg 40.55 Purity: ≥98% 153674 [35788-27-3] 10 mg 72.25 An NMDA receptor antagonist and o α dopamine release stimulator. 0-5 C An 2-adenine agonist. 25 mg 144.60 • C11H14N6O4 MW 294.3 C12H21N HCl MW 215.8

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ MESULERGINE 10 mg 68.50 6-METHOXY-2-NAPHTHYLACETIC 5 mg 80.25 193682 [64795-35-3] 50 mg 275.00 159968 ACID 10 mg 145.65 RT Hydrochloride RT [23981-47-7] 25 mg 315.30 A dopaminergic receptor agonist and Purity: 99% 5-HT1C serotonin receptor antagonist. Selectively inhibits PGH synthase-2 over C18H26N4O2S • HCl MW 398.9 PGH synthase-1. Ref.: Meade, E.A., et al., J. Biol. Chem., 268, 6610 (1993). DL-METANEPHRINE 25 mg 14.15 195310 [5001-33-2] 100 mg 39.90 MW 216.2 RT (DL-m-O-Methylepinephrine) 250 mg 78.75 1 g 25.00 Hydrochloride 500 mg 115.50 1-(2-METHOXYPHENYL) PIPERAZINE 151629 5 g 100.00 Crystalline 1 g 183.75 [5464-78-8] C H NO • HCl MW 233.7 RT (2-MPP) 10 15 3 Hydrochloride Selective 5-HT1 receptor agonist METANEPHRINE ELISA KIT 1 each 595.00 Crystalline 193593 This metanephrine ELISA kit provides Purity: 98-99% o 0-5 C materials for the quantitative measurement C11H16N2O • HCl MW 228.7 of chemically derivatized metanephrine in urine. The assay procedure follows the N-[2-(METHYLAMINO)ETHYL]-5- 10 mg 68.75 basic principle of competitive ELISA 158956 ISOQUINOLINESULFONAMIDE 25 mg 157.65 whereby there is competition between a 0oC [84478-11-5] 50 mg 286.65 biotinylated and non-biotinylated antigen for (H-8) a fixed number of antibody binding sites. Dihydrochloride The kit is a 12 x 8 well format. Purity: 99% Specifically inhibits PKA and PKG over FOR RESEARCH USE ONLY! PKC and MLCK. Ref.: 1. Hidaka, H., et.al., Biochemistry, 23, METERGOLINE PHENYLMETHYL 5 mg 16.55 5036 (1984). 2. Hagiwara, M., et.al., Mol. 193683 25 mg 49.60 Pharmacol., 31, 523 (1987). ESTER C • RT [17692-51-2] 50 mg 90.40 12H15N3O2S 2HCl MW 338.3 A serotonin antagonist at the 5-HT1/5-HT2 G receptor. N -METHYL-D-ARGININE 5 mg 38.00 C H N O MW 403.5 159625 [137694-75-8] 25 mg 150.00 25 29 3 2 RT Acetate Salt C7H16N4O2 • C2H4O2 MW 248.3 METHACHOLINE CHLORIDE 5 g 11.45 G 100005 [62-51-1] 10 g 20.05 N -METHYL-L-ARGININE 5 mg 13.50 0oC (Acetyl-β-methylcholine chloride) 155470 [53308-83-1] 25 mg 49.00 C8H18ClNO2 MW 195.7 RT Acetate Salt 100 mg 159.00 Endothelium-derived relaxing factor inhibitor Ref.: Sakuma, I., et al., Proc. Nat. Acad. METHACHOLINE CHLORIDE 5 g 17.75 Sci. USA, 85, 8664 (1988). 190231 [62-51-1] 10 g 28.10 C H N O • C H O MW 248.3 0oC (Acetyl-β-methylcholine chloride) 25 g 55.90 7 16 4 2 2 4 2 Crystalline 100 g 183.45 N-METHYL-D-ASPARTIC ACID 25 mg 25.00 Cholinergic agonist 153672 [6384-92-5] 80 mg 55.00 C8H18ClNO2 MW 195.7 0-5oC (NMDA) 250 mg 105.00 C5H9NO4 MW 147.1 METHIOTHEPIN MALEATE 100 mg 45.90 158953 [19728-88-2] 250 mg 109.20 N-METHYL-β-CARBOLINE-3- 10 mg 18.40 RT Purity: 99% 500 mg 208.70 153671 CARBOXAMIDE 25 mg 43.35 Inhibitor of 5-HT release from brain RT [78538-74-6] structures whether electrical or potassium (FG-7142) induced. Potent 5-HT autoreceptor Benzodiazipine inverse agonist antagonist and demonstrates activity as a C13H11N3O MW 225 5-HT1C antagonist. Ref.: 1. Pazos, A., et.al., Eur. J. METHYL β-CARBOLINE-3-CARBOXYLATE Pharmacol., 106, 539 (1985). 2. Ennis, C. and Cox, B., Neuropharmacology, 21, 41 See: β-Carboline-3-carboxylic acid methyl ester (1982). 3. Raiteri, M., et.al., J. Pharamcol. Exp. Ther., 237, 644 (1986). 4. Rebec, METHYL-6,7-DIMETHOXY-4-ETHYL-β- 10 mg 42.70 G.V., et.al., Brain Res., 251, 374 (1982). 153669 CARBOLINE-3-CARBOXYLATE 25 mg 101.25 0-5oC [82499-00-1] METHOCTRAMINE 1 mg 28.85 (DMCM) 153664 [104807-40-1] 5 mg 72.25 C17H18N2O4 MW 314.3 RT Hydrochloride 10 mg 115.70 C36H62N4O2 • 4HCl MW 728.8 N-METHYLDOPAMINE 25 mg 22.40 153658 [62-32-8] 50 mg 36.15 0-5oC Hydrochloride 100 mg 72.25 8-METHOXYMETHYL-1-METHYL-3-(2- 5 mg 46.00 Dopamine agonist 158955 25 mg 156.00 METHYLPROPYL)XANTHINE C9H13NO2 • HCl MW 203.7 RT (8-Methoxymethyl-IBMX) Purity: 98% α,β-METHYLENEADENOSINE-5′′′- 1 mg 28.00 Specifically inhibits 2+ 195317 TRIPHOSPHATE 5 mg 112.00 Ca -calmodulin-dependent 0oC [58337-46-5] phosphodiesterase. (AMP-CPP; Adenosine Ref.: 1. Wells, J.N. and Miller, J.R., ′ α β Methods Enzymol., 159, 489 (1988). 2. 5 -[ , -methylene]triphosphate dilithium Ahn, H.S., et.al., Biochem. Pharmacol., , hydrate) 38 Dilithium hydrate 3331 (1989). ∼ MW 266.3 Purity: 95% C11H18N5O12P3 MW 505.2

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ R(-)-α-METHYLHISTAMINE 5 mg 56.15 METHYL [5-(2-THIENYL- 1 mg 10.90 159969 Dihydrobromide 10 mg 94.00 152405 CARBONYL)-1H-BENZ- 5 mg 29.40 RT Purity: 99% 25 mg 192.60 0-5oC IMIDAZOLE-2-YL]-CARBAMATE 25 mg 106.95 Selective and potent agonist of histamine [31430-18-9] 50 mg 189.00 H3. (Nocodazole; R 17934) Ref.: 1. Arrang, J.M., et al., Nature, 327, Purity: 99% 117 (1987). A synthetic microtubule inhibitor shown to 2. Hew, R.W.S., et al., Brit. J. Pharmacol., induce the disappearance of microtubules 101, 621 (1990). from neoplastic cells in vivo and C6H11N3 • 2HBr MW 287 mammalian cells in culture. C H N O S MW 301.3 N-ω-METHYL-5- 25 mg 29.40 14 11 3 3 155578 100 mg 104.60 o HYDROXYTRYPTAMINE 2-METHYLTHIOADENOSINE 2 mg 86.75 0-5 C [1975-81-1] 500 mg 475.00 153663 TRIPHOSPHATE 5 mg 144.60 ω o (N- -Methylserotonin) -20-0 C [43170-89-4] 10 mg 260.30 Oxalate Salt • Tetrasodium Salt C11H14N2 C2H2O4 MW 280.3 C11H14N5Na4O13P3S MW 641.2 α 2 mg 50.60 -METHYL-5-HYDROXYTRYPTAMINE 1 mg 65.00 153621 [304-52-9] 5 mg 115.70 bis(METHYLTHIO)GLIOTOXIN o 159073 [74149-38-5] 5 mg 290.00 -20-0 C α 10 mg 224.10 o ( -Methylserotonin maleate) -20 C (FR-49175) A 5-HT2 serotonin agonist. Purity: 99% Maleate Salt • Blocks platelet and collagen induced C11H14N2O C4H4O4 MW 306.3 aggregation. 5-(N-METHYL-N- 5 mg 22.05 Ref.: 1. Okamoto, M., et.al., Chem. Pharm. 193685 ISOBUTYL)AMILORIDE 25 mg 90.40 Bull., 34, 340 (1986). 2. Okamoto, M., et.al., 0-5oC [96861-65-3] ibid., 34, 345 (1986). (MIA) MW 356.5 Very potent Na+/H+ antiporter inhibitor. C H N OCl MW 299.8 8-METHYL-N-VANILLYLNONANAMIDE 25 mg 25.00 11 18 7 159588 [2566-32-7] 100 mg 75.00 o S-METHYLISOTHIOUREA 100 g 13.60 0-5 C (Dihydrocapsaicin) 155590 [867-44-7] 500 g 46.70 Purity: ~90% RT (2-Methyl-2-thiopseudourea) C18H29NO3 MW 307.4 Hemisulfate Salt Crystalline 8-METHYL-N-VANILLYL-6- 25 mg 28.65 159843 100 mg 68.75 A competitive inhibitor of inducible nitric o NONENAMIDE oxide synthase (iNOS) at L-arginine binding 0-5 C [404-86-4] 500 mg 206.35 sites. (Capsaicin) C2H6N2S • 1/2H2SO4 MW 139.2 Purity: °98% Substantially free of dihydrocapsaicin. This METHYL OKADAATE 50 µg 118.95 is a purified form of the neurotoxic 158383 [78111-14-5] 100 µg 212.85 component of cayenne pepper. Stimulates 0-5oC Purity ≥ 98% excitatory afferent sensory neurons via Serine/Threonine protein phosphatase divalent cation channel activation. inhibitor Ref.: Holzer, Neuroscience, 24, 739 (1988). C45H70O13 MW 819.04 C18H27NO3 MW 305.4 METHYL-2-(PHENYLTHIO)ETHYL-1,4- 5 mg 64.00 METOCLOPRAMIDE 1 g 36.15 159185 10 mg 112.00 o DIHYDRO-2,4,6-TRIMETHYL- 153559 [364-62-5] 5 g 108.45 0 C PYRIDINE-3,5-DICARBOXYLATE RT Hydrochloride (PCA-4248) 5-HT3 serotonin antagonist Purity: 98% C14H22ClN3O2 • HCl MW 336.3 Inhibitor of [3H]-platelet activating factor to platelets and PMNL receptors. Also blocks METOLAZONE 25 mg 10.90 plate aggregation. 153617 [17560-51-9] 50 mg 14.45 Ref.: Ortega, M.P., et.al., J. Pharmacol. RT Diuretic; anti-hypertensive 100 mg 26.10 Exp. Ther., 255, 28 (1990). C16H16N3O3SCl MW 365.8 MW 361.4 α α β METOPROLOL TARTRATE 1 g 9.00 (5 ,7 ,8 )-(+)-N-METHYL-N-(7-[1- 1 mg 18.00 190018 [56392-17-7] 5 g 31.00 155653 10 mg 148.00 o PYRROLIDINYL]-1- RT Crystalline powder 10 g 56.00 0-5 C OXASPIRO[4.5]DEC-8-YL)- A β-adrenergic compound. BENZENEACETAMIDE (C15H25NO3)2 • C4H6O6 MW 684.8 [96744-75-1] (U-69,593) MEVASTATIN 5 mg 54.00 A kappa agonist 159971 [73573-88-3] Ref.: Gillan, M.G.C. and Kosterlitz, H., Br. -20oC (Compactin) J. Pharmac., 77, 461 (1982). Purity: 95% C22H32N2O2 MW 356.5 HMG-CoA reductase inhibitor. C H O MW 390.5 METHYLSERGIDE 1 mg 52.90 23 34 5 193686 [129-49-7] 5 mg 213.90 MEZEREIN 1 mg 128.80 RT Maleate Salt 151692 [34807-41-5] 5 mg 343.40 Serotonin receptor antagonist. o • 0 C (Daphnetoxin) C21H27N3O2 C4H4O4 MW 469.5 Co-inducer of interferon C H O MW 654.7 α-METHYLSEROTONIN MALEATE 38 38 10 See: α-Methyl-5-hydroxytryptamine maleate MIANSERIN 25 mg 14.45 153619 [21535-47-7] 50 mg 21.75 0-5oC Hydrochloride 100 mg 39.80 2-METHYLSEROTONIN MALEATE Serotonin antagonist See: 2-Methyl-5-hydroxytryptamine maleate C18H20N2 • HCl MW 300.8

One call. One source. 1197 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ MICROCYSTIN-LR 100 µg 95.00 MOLLUSCAN CARDIOEXCITATORY 1 mg 19.50 158379 [101043-37-2] 500 µg 370.00 151703 NEUROPEPTIDE 0-5oC Purity ≥ 98% 0oC [64190-70-1] Heptapeptide ester hepatotoxin Phe-Met-Arg-Phe-NH2 Equally potent in inhibition of protein Ref.: Price, Science, 197, 670 (1977) phosphatases 1 and 2A (PP1 and PP2A); PP2B is less sensitive and PP2C is not MOLSIDOMINE 500 mg 34.40 µ 159818 [25717-80-0] 1 g 61.90 inhibited up to 4 M; useful for affinity o purification of PP2A. 0-5 C (N-(Ethoxycarbonyl)-3-(4-morpholinyl)sydnon 5 g 246.55 Not cell permeable. e imine; SIN-10) Ref: 1. J. Biol. Chem., (1988), 110, Precursor which is converted to the active 8557-8558. metabolite SIN-1. 2. FEBS Lett., (1990), 264, 187-192. C9H14N4O4 MW 242.2 3. J. Biol. Chem., (1990), 265, MONENSIN 500 mg 34.00 19401-19404. 190241 [22373-78-0] 1 g 59.50 C49H74N10O12 MW 995.2 0oC Sodium Salt Antibiotic that functions as an ionophore by MILRINONE 10 mg 170.00 forming stable complexes with monovalent 158962 [78415-72-2] 25 mg 380.00 o cations. -20-0 C (1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5 Ref.: Gertenbach, P.G. and Popov, A.I., J. -carbonitrile) Am. Chem. Soc., 97, 4738 (1975). Purity: 97% C36H61O11Na MW 692.9 Specifically inhibits cGMP-inhibited phosphodiesterase. Strong cardiotonic MONENSIN METHYL ESTER 10 mg 29.80 159626 MW 684.9 25 mg 59.65 positive inotropic vasodilator. o Ref.: 1. Harrison, S.A., et.al., Mol. 0 C 100 mg 212.10 Pharmacol., 29, 506 (1986). 2. Ahn, S., et.al., Biochem. Pharmacol., 35, 1113 MORPHICEPTIN 1 mg 15.85 152956 (β-Casomorphin [1-4] Amide; 5 mg 40.55 (1986). 3. Alousi, A.A., et.al., J. Cardiovas. o Pharmacol., , 792 (1983). -20-0 C Tyr-Pro-Phe-Pro-NH2) 10 mg 65.85 5 µ C12H9N3O MW 211.2 A highly preferential ligand for the -opiate (morphine) receptor. Ref: Chang, K.J., et al., Science, 212, 75 L-MIMOSINE 25 mg 10.00 159973 [500-44-7] 100 mg 18.75 (1981). β α RT ( -[N-(3-Hydroxy-4-pyridone)- -aminopropio 500 mg 75.00 3-MORPHOLINOSYDNONIMINE HYDROCHLORIDE nic acid) 1 g 138.00 Purity: 99% See: SIN-1 A rare amino acid from plants which reversibly blocks the G1 phase of the cell MUREXIDE 1 g 6.60 cycle. Deoxyhypusine hydroxylation 102433 [3051-09-0] 5 g 12.25 inhibitor that subsequently inhibits RT (Ammonium purpurate) 25 g 41.05 eukaryote initiation factor 5-A. Reddish-brown crystals. Ref.: Hanauske-Abel, H.M., et al., Biochim. Indicator for calcium determination. Biophys. Acta, 1221, 115 (1994). C8H8N6O6 MW 284.2 C8H10N2O4 MW 198.2 MUSCIMOL 1 mg 17.05 195336 [2763-96-4] 5 mg 53.00 MINOXIDIL 25 mg 24.10 0oC (3-Hydroxy-5-aminomethylisoxazole) 10 mg 84.00 155719 [38304-91-5] 100 mg 68.00 Crystalline 25 mg 168.00 RT (6-[1-Piperidinyl]pyrimidine-2,4-diamine 3 250 mg 149.00 Structural analog of γ-amino butyric acid. oxide) 500 mg 260.00 Functions as a GABA-agonist: a positive Stimulates ATP-activated potassium-ion analog of the natural transmitter, which can channels. activate GABA receptors in the brain. Ref: Gorecki, Anal. Profiles Drug Subst., C4H6N2O2 MW 114.1 17, 185 (1988). C9H15N5O MW 209.3 MUSCIMOL 10 mg 90.00 151720 Hydrobromide 25 mg 180.00 o MINOXIDIL SULFATE 1 mg 19.00 0-5 C GABA agonist, water soluble 100 mg 650.00 158963 (U-58838) 5 mg 75.00 C4H6N2O2 • HBr MW 275.9 RT Purity: 98% + MUSCONE 100 mg 80.25 Specifically opens ATP-sensitive K 159186 [541-91-3] 250 mg 177.70 channels. Strong vascular smooth muscle RT Purity: 99% 500 mg 332.55 relaxer. Also, an active metabolite of Cytochrome P450 inducer in rats. minoxidil. Ref.: 1. Peng, R., et.al., Biochem. Ref.: 1. Winquist, R.J., et.al., J. Pharmacol. Pharmacol., 35, 1391 (1986). 2. Tanaka, E., Exp. Ther., 248, 149 (1989). 2. Meisheri, K., et.al., ibid., 41, 472 (1991). et.al., J. Pharmacol. Exp. Ther., 245, 751 C H O MW 238.4 (1988). 3. Gadwood, R.C. and Fiedler, V.C., 16 30 Annu. Rep. Med. Chem., 24, 187 (1989). MYELIN BASIC PROTEIN, 1 mg 87.00 • C9H15N5O SO3 MW 289.3 159627 Fragment 4-14 0oC [126768-94-3] MITHRAMYCIN A 1 mg 55.00 Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Le 191240 [18378-89-7] 5 mg 235.05 u 0-5oC From Streptomyces plicatus Reported to be the most specific substrate C52H76O24 MW 1085.2 for protein kinase C. Ref.: Yasuda, I., et al., Biochem. Biophys. (+)-MK 801 MALEATE 5 mg 22.00 Res. Comm., 166, 1220 (1990). 193687 [77086-22-7] 25 mg 88.00 MW 1390.6 RT (Dizocilpine) MYELIN BASIC PROTEIN, 1 mg 181.10 A very potent, selective non-competitive 159628 Fragment 104-118 NMDA receptor antagonist. o 0 C Gly-Lys-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Arg-Ph U.S.patent 4,399,141 (Merck & Co., Inc.) C H N • C H O MW 337.4 e-Ser-Trp-Gly-Ala 16 15 4 4 4 MW 1578.8 To place an order: (800) 854-0530, fax (800) 334-6999 1198 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ Des[Gly77,His78]-MYELIN BASIC 1 mg 177.70 NALIDIXIC ACID 1 g 7.40 159975 PROTEIN, Fragment 68-84 151724 [3374-05-8] 5 g 22.50 0oC [98474-59-0] 0oC (1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naph 25 g 78.25 Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ala-Gln-Arg-Pro thyridine-3-carboxylic acid) 100 g 216.00 -Gln-Asp-Glu-Asn Sodium Salt Purity: 95% Crystalline Species: Bovine C12H11N2O3Na MW 254.2 Ref.: Mannie, M., et al., Proc. Natl. Acad. Sci. USA, 82, 5515 (1985). NALOXONAZINE 2 mg 25.35 MW 1730.9 153613 [82824-01-9] 5 mg 57.80 o (Bis 0.1 mg 36.40 0-5 C 10 mg 108.45 MYELIN BASIC PROTEIN, [5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propen 155746 Fragment 68-82 0.5 mg 121.25 yl) morphinan-6-ylidene] hydrazine) 0oC [98474-59-0] 1 mg 201.90 77 78 75,80 Opioid antagonist at µ1 receptors. (des[Gly ,His ]-Ser -Myelin Basic C H N O MW 650.8 Protein Bovine Fragment 68-84) 38 42 4 6 Guinea Pig (Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-S NALOXONE 25 mg 12.40 190245 [357-08-4] 100 mg 26.80 er-Gln-Asp-Glu-Asn) o Ref.: Mannie, M., et al., Proc. Nat. Acad. 0-5 C Hydrochloride 250 mg 51.60 Sci. USA, 82, 5515 (1985). Crystalline 1 g 139.60 MW 1736.8 A specific opiate antagonist. C19H21NO4 • HCl MW 363.8 MYOSIN KINASE INHIBITING 1 mg 77.95 154586 PEPTIDE 5 mg 361.50 NALTREXONE 250 mg 89.00 0-5oC Lys-Lys-Arg-Ala-Ala-Arg-Ala- 151725 [16676-29-2] Thr-Ser-NH2 RT (N-Cyclopropylmethyl-14-hydroxydihydromor Ref.: Pearson, R.B., et al., (1986), J. Biol. phinone) Chem., 261, 25 (1986). Hydrochloride MW 988.2 Narcotic antagonist, congener of Naloxone, C H NO • HCl MW 377.9 MYOSIN LIGHT CHAIN KINASE 1 mg 131.90 20 23 4 159631 INHIBITOR o NALTRINDOLE 1 mg 17.65 -20-0 C Lys-Arg-Arg-Trp-Lys-Lys-Asn-Phe-Ile-Ala-Val 193690 [111469-81-9] 5 mg 68.35 -20oC (NTI) 10 mg 123.50 MW 1444.9 Hydrochloride MYOSIN LIGHT CHAIN KINASE 1 mg 166.25 Very selective non-peptide δ-opioid 159632 SUBSTRATE receptor antagonist. o -20-0 C Skeletal muscle C26H26N2O3 • HCl MW 450.6 Ala-Lys-Arg-Pro-Gln-Arg-Ala-Thr-Ser-Asn-Va l-Phe-Ser NAN-190 50 mg 73.35 MW 1460.80 158964 [115338-32-4] 100 mg 139.90 RT Hydrobromide 250 mg 333.70 MYOSIN LIGHT CHAIN KINASE 1 mg 131.90 Purity: 98% 159633 o SUBSTRATE 5-HT1A antagonist. -20-0 C Smooth muscle Ref.: 1. Glennon, R.A., et.al., J. Med. Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val Chem., 31, 1968 (1988). 2. Glennon, R.A., -Phe-Ala et.al., Eur. J. Pharmacol., 154, 339 (1988). MW 1418.8 C23H27N3O3 • HBr MW 474.4 MYXOTHIAZOL 1 mg 35.70 155765 [76706-55-3] 5 mg 184.60 NAPHTHORESORCINOL 1 g 20.00 0-5oC Purity: 95% 102409 [132-86-5] 5 g 91.00 From Myxobacterium RT (1,3-Dihydroxynaphthalene; 10 g 173.40 (Myxococcus fulvus) 1,3-Naphthalenediol) Reported to inhibit cytochrome b-c, in the Light brown crystals. mitochrondria responsible for the Purity: ∼95% respiratory chain. Potent inhibitor of prostaglandin synthetase. Ref.: Thierbach, G. and Reichenbach, H., Reagent for determination of serine and Biochim. glucuronic acid. Biophys. Acta. 638, 282 (1981). C10H8O2 MW 160.2 C25H33N3O3S2 MW 487.7 1-NAPHTHOXYLACTIC ACID 10 mg 27.55 -N- 193692 A metabolite of propranolol. 50 mg 110.25 RT C13H12O4 MW 232.2 NAFTOPIDIL 10 mg 29.75 193688 [57149-07-2] 50 mg 119.05 25 mg 43.35 RT Dihydrochloride 1-(1-NAPHTHYL)PIPERAZINE α 153612 [57536-86-4] 50 mg 79.55 An 1-adrenoceptor antagonist. 0-5oC Hydrochloride 100 mg 151.90 C24H28N2O3 • 2HCl MW 465.4 Serotonin 5-HT1 agonist; 5-HT2 antagonist. NALBUPHINE 50 mg 45.90 C14H16N2 • HCl MW 248.8 151723 (N-Cyclobutylmethyl-14-hydroxy-dihydromorp 250 mg 180.55 RT hine) 1 g 382.85 NAPROXEN 1 g 6.60 Hydrochloride 190247 [22204-53-1] 5 g 21.50 Analgesic and narcotic antagonist RT (S(+)-6-methoxy-α-methyl-2-naphthaleneace 25 g 77.00 C21H27NO4 • HCl MW 393.9 tic acid) 50 g 127.75 5 g 10.20 [S(+)-2-(6-Methoxy-2-naphthyl)propionic NALIDIXIC ACID acid] 190246 [389-08-2] 25 g 31.80 Pharmacological agent that reportedly may RT (1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naph 100 g 116.15 show activity through ability to inhibit thyridine-3-carboxylic acid) prostaglandin biosynthesis. Free Acid Ref.: Tomlinson, et al., Biochem. Biophys. Crystalline Res. Commun., 46, 552 (1972). DNA Polymerase Inhibitor. C14H14O3 MW 230.3 C12H12N2O3 MW 232.2 One call. One source. 1199 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ NBQX 1 mg 33.60 NEUROPEPTIDE Y 0.5 mg 242.70 195945 [118876-58-7] 5 mg 131.25 151739 [82785-45-3] 1 mg 438.15 RT (FG 9202; -20-0oC (NPY; 6-Nitro-7-sulphamoylbenzo[f]quinoxaline-2,3- Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-As dione; p-Ala-Pro-Ala-Glu- 2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo[f]q Asp-Leu-Ala-Arg-Tyr-Tyr-Ser- uinoxaline) Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu- Purity: ≥95% Ile-Thr-Arg-Gln-Arg-Tyr-NH2) Selective and potent AMPA/Kainate Source/Species: Porcine receptor antagonist. Acts as a Ref: Tatemoto, K., et al., Proc. Natl. Acad. neuroprotectant. Sci. (USA), 79, 5485 (1982). C12H8N4O6S MW 336.3 MW 4253.7 NEUROPEPTIDE Y 500 µg 240.85 191468 [90880-35-6] 1 mg 435.05 NEAMINE 5 mg 20.60 o 158966 [3947-65-7] 10 mg 39.00 -20-0 C (NPY; 0-5oC (U-5214) 25 mg 93.15 Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-As Purity: 97% 50 mg 168.00 p-Ala-Pro-Ala-Glu- Increases phosphatidylinositol 4-phosphate Asp-Met-Ala-Arg-Tyr-Tyr-Ser- kinase activity specifically over PI kinase Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu- activity. It may increase permeability in Ile-Thr-Arg-Gln-Arg-Tyr-NH2) PI-containing membranes. Source/Species: Human Ref.: 1. Quist, E., et.al., Arch. Biochem. MW 4271.7 Biophys., 271, 21 (1989). 2. Au, S., et.al., 500 µg 150.95 Biochem. Biophys. Acta., 902, 80 (1987). NEUROPEPTIDE Y, 154449 Fragment 13-36 1 mg 276.10 C H N O MW 322.4 o 12 26 4 6 0-5 C [113662-54-7] H2N-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Se NEOMYCIN SULFATE 1 g 6.50 r-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg 100541 [1405-10-3] 5 g 8.55 -Gln-Arg-Tyr- NH2 RT µ 10 g 10.15 Source/Species: Porcine Minimum 630 g Neomycin/mg Ref.: Walker, M.W. and Miller, R.J., (1988), White powder. 25 g 20.35 Mol. Pharm., 34, 779 Approx. 90-95% Neomycin B. 100 g 70.55 Antibiotic, also used in tissue culture MW 2982.7 studies. NEUROTROPHIN 3 1 µg 209.45 Can act as an inhibitor of protein 193951 (NT-3) biosynthesis. o • -20 C Human, Recombinant C23H46N6O13 3H2SO4 MW 908.9 This neurotrophin promotes neuronal survival and growth. Ref.: Mainsonpierre, et al., Science, 247, NEOMYCIN SULFATE 1 g 8.80 1447 (1990). 194533 [1405-10-3] 5 g 11.00 MW 28 kDa RT Cell Culture Reagent 10 g 13.75 Minimum 630 µg Neomycin/mg 25 g 24.25 NEUROTROPHIN 3 5 µg 396.90 White powder. 100 g 87.10 193952 (NT-3) Approx. 90-95% Neomycin B. -20oC Human, Recombinant Antibiotic Produced in E. coli Acts as an inhibitor of protein biosynthesis. Purity: ≥95% C23H46N6O13 • 3H2SO4 MW 908.9 A neurotrophin that promotes neuronal growth. MW ∼28 kDa 10 mg 38.35 NEOPTERIN µ 153611 [2009-64-5] 15 mg 54.95 NEUROTROPHIN 4 5 g 396.90 o 193954 (NT-4) 0-5 C [D(+)-6-(erythro-1,2,3-Trihydroxypropyl) 25 mg 86.75 o pterin] -20 C Human, Recombinant C9H11N5O4 MW 253.2 Produced in E. coli Purity: ≥95% A neurotrophin that promotes neuronal 1 mg 30.20 growth. NEOPYRITHIAMINE ∼ 102434 [534-64-5] 5 mg 140.80 MW 28 kDa o 0-5 C (Pyrithiamine) 10 mg 268.20 NIALAMIDE 250 mg 44.45 Hydrobromide 191508 [51-12-7] 500 mg 80.10 Thiamine Antagonist o ′ ∼ 0 C (N-isonicotinoyl-N Purity: 95% β Yellow to off-white crystals. [ -(N-benzyl-carboxamido) ethyl] C H N O • 2HBr MW 420.1 hydrazine; 14 18 4 N-Benzyl-β-[isonicotinyl-hydrazine] propionamide) Crystalline NEOSTIGMINE BROMIDE 250 mg 10.25 ∼ 153553 [114-80-7] 1 g 15.25 Purity: 95% RT [3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trim Monoamine Oxidase inhibitor ethylbenzenaminium bromide] C16H18N4O2 MW 298.3 Inhibitor of acetylchloinesterase NICARDIPINE 1 g 35.80 C12H19BrN2O2 MW 303.2 190244 [55985-32-5] 5 g 140.60 0-5oC (1,4-Dihydro-2,6-dimethyl-4-[3-nitrophenyl]me 10 g 253.20 thyl-2-[methyl- NEOSTIGMINE METHYL SULFATE 1 g 20.50 (phenyl-methl)amino]-3,5- 155816 [51-60-5] 5 g 62.20 o pyridinedicarboxylic acid ethyl ester) 0 C [3-[([Dimethylamino]carbonyl)-oxy]-N,N,N-trim 10 g 103.20 Hydrochloride ethylbenzaminium methyl sulfate] 25 g 205.50 Cerebral and coary vasodilator with calcium Crystalline blocking activity. Structurally related to C13H22N2O6S MW 334.4 Nifedipine. C26H29N3O6 • HCl MW 516

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ NICERGOLINE 1 mg 9.50 NITR 7 1 mg 67.60 155824 [27848-84-6] 5 mg 13.10 152420 A photolabile calcium chelator. NITR 7 5 mg 308.45 0-5oC (5-Bromonicotinic acid 25 mg 44.10 0oC binds calcium approx. 3 times more tightly 10-methoxy-1,6-dimethylergoline-8-methano 100 mg 136.50 than NITR 5, but also releases it with a l ester) higher time constant (1.8 milliseconds vs. Free Acid 300 microseconds). Purity: ∼98% Ref.: Gurney, A.M., Tsien, R.Y., Lester, An α-adrenergic H.A., Proc. Natl. Acad. Sci. USA, 84, 3496 C24H26BrN3O3 • C4H4O4 MW 600.4 (1987). C34H35N3O15 MW 725.7 NICORANDIL ANALOG See: N-[2-(Acetoxy)ethyl]-3-pyridinecarboxamide NITRENDIPINE 5 mg 14.85 159789 [39562-70-4] 10 mg 26.35 (-)-NICOTINE 5 ml 12.20 RT An L-type calcium channel blocker. 50 mg 105.50 190671 [54-11-5] 25 ml 41.20 C18H20N2O6 MW 360.4 RT (L-1-Methyl-2-[3-pyridyl]pyrrolidine) 100 ml 83.50 Free Base N-ω-NITRO-L-ARGININE 1 g 11.25 Purity: 98-100% 102503 [2149-70-4] 5 g 44.05 Clear light yellow liquid RT Crystalline 10 g 79.10 C10H14N2 MW 162.2 C6H13N5O4 MW 219.2 ± ( )-NICOTINE 100 mg 38.55 N-ω-NITRO-L-ARGININE METHYL 5 g 34.70 155830 [22083-74-5] 500 mg 114.70 155846 ESTER 10 g 61.85 RT C10H14N2 MW 162.2 0oC [51298-62-5] 25 g 142.00 50 mg 33.45 Hydrochloride (+)-NICOTINE Crystalline 155829 [68935-27-3] 250 mg 111.35 • 0-5oC (+)-Di-p-toluoyltartrate Salt C7H15N5O4 HCl MW 269.7 C H N • C H O MW 548.6 10 14 2 20 18 8 S-(p-NITROBENZYL)-6- 10 mg 14.05 (-)-NICOTINE 250 mg 10.90 155872 THIOGUANOSINE 25 mg 31.00 153554 [65-31-6] 1 g 21.75 0-5oC [13153-27-0] 100 mg 112.00 RT [(S)-3-(1-Methyl-2-pyrrolindinyl)pyridine] (S-(4-Nitrobenzyl)-6-thioguanosine; Tartrate Salt 2-Amino-6-[(4-nitrobenzyl)thio]-9-β- C10H14N2 • 2C4H6O6 MW 462.4 D-ribofuranosylpurine; NBTGR) Strong inhibitor for the transport of NIFEDIPINE 1 g 12.45 nucleosides. 151743 [21829-25-4] 5 g 34.35 o Ref.: 1. Can.J.Biochem., 49, 271 (1971). 0-5 C [1,4-Dihydro-2,6-dimethyl-4-(2- 10 g 52.75 2. Ann. N.Y.Acad.Sci., 255, 402 (1975). nitrophenyl)-3,5-pyridine- 25 g 93.85 Yellow powder. dicarboxylic acid dimethyl ester] C H N O S MW 434.4 Purity: 95% 17 18 6 6 Yellow crystalline powder S-(p-NITROBENZYL)-6-THIOINOSINE 25 mg 35.80 A calcium-channel blocker. 100 mg 120.40 C H N O MW 346.3 155873 [38048-32-7] 17 18 2 6 0oC (S-(4-Nitrobenzyl)-6-thioinosine; 250 mg 263.70 NIGERICIN 1 mg 40.15 6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpuri 195345 [28380-24-7] 5 mg 176.40 ne; NBMPR) 0-5oC Mixture of sodium and potassium salts 10 mg 420.20 Useful tool in cancer research as a very Purity: ∼95% strong inhibitor for the transport of A polyether antibiotic that affects ion nucleosides. transport and ATPase activity in Ref.: Cancer Res., 39, 1245 (1979). mitochondria. Crystalline Ref.: Sze, H., Proc. Nat. Acad. Sci. U.S.A., C17H17N5O6S MW 419.4 77, 5904 (1980). C40H67O11Na MW 747 7-NITROINDAZOLE 1 mg 8.40 159790 [2942-42-9] 5 mg 19.95 (±)-NIGULDIPINE 1 mg 11.45 -20oC Purity: ≥97% 25 mg 63.00 159802 [113317-61-6] 5 mg 32.05 o Inhibitor of nitric oxide synthase. 0-5 C Hydrochloride 25 mg 128.40 Ref.: Moore, et al., Brit. J. Pharm., 110, 219 Very powerful α1A-adrenergic inhibitor. (1993). • C36H39N3O6 HCl MW 646.2 C7H5N3O2 MW 163.1 NIMODIPINE 10 mg 13.75 159803 [66085-59-4] 25 mg 27.50 7-NITROINDAZOLE 1 mg 10.50 193697 Monosodium Salt 5 mg 35.70 RT Potent calcium channel antagonist. 100 mg 110.10 o ≥ Ref.: Kappelle, et al., Brit. J. Pharm., 111, -20 C Purity: 95% 25 mg 141.75 887 (1994). Slightly water soluble salt of 7-nitroindazole, C H N O MW 418.4 a selective inhibitor of nitric oxide synthase 21 26 2 7 (NOS). NISOXETINE 5 mg 47.40 C7H4N3O2Na MW 185.1 193694 [57754-86-6] 25 mg 189.65 RT Hydrochloride 5-NITRO-2-(3- 10 mg 57.35 A selective norepinephrine uptake inhibitor. 158967 PHENYLPROPYLAMINO)-BENZOIC 25 mg 131.90 • C17H21NO2 HCl MW 307.8 RT ACID 50 mg 252.25 NITR 5 1 mg 67.60 [107254-86-4] 152419 A photosensitive calcium chelator. Useful in 5 mg 308.45 Purity: 98% 0oC a variety of systems where short pulses of Cyclooxygenase inhibitor and potent rapidly released calcium may be used to chloride channel blocker. probe associated physiological responses. Ref.: 1. Diener, M. and Rummel, W., Acta Ref.: 1. Tsien, R. and Zucker, R.S., Physiol. Scand., 137, 215 (1989). 2. Biochem. J., 50, 843 (1986). 2. Gurney, Wangemann, P., et.al., Pflugers Arch., 407, A.M., Tsien, R.Y., and Lester, H.A., Proc. s128 (1986). 3. Breuer, W., et.al., Biochem. Natl. Acad. Sci. USA, 84, 3496 (1987). Biophys. Res. Commun., 163, 398 (1989). C16H16N2O4 MW 300.3 C31H31N3O15 MW 685.6

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 3-NITROPROPIONIC ACID 5 g 166.10 NOC-15 5 mg 36.75 155923 [504-88-1] 159824 [146672-58-4] 10 mg 50.40 0-5oC An inhibitor of succinic dehydrogenase and -20oC (PAPA NONOate; 25 mg 121.50 a neurotoxin shown to cause brain lesions 1-Hydroxy-2-oxo-3-(3-aminopropyl)-3-propyl- resembling those of Huntington’s Disease. 1-triazene) May produce a yellow solution in alcohol. Crystalline C3H5NO4 MW 119.1 Purity: ≥98% A nitric oxide (NO) donor. Half-life time of 6-NITROQUIPAZINE MALEATE 5 mg 75.00 NO release at 22 °C and pH 7.4 in 0.1 M 158968 Purity: 98% 20 mg 261.00 phosphate buffer is 76.6 minutes. RT 5-HT uptake inhibitor. Ref.: 1. Hrabie, J.A., et al., J. Org. Chem., Ref.: 1. Hashimoto and Goromaru, Eur. J. 58, 1472 (1993). Pharmacol., 180, 273 (1990). 2. Hashimoto 2. Maragos, C.M., et al., Cancer Res., 53, and Goromaru, Biochem. Pharmacol., 41, 564 (1993). 1679 (1991). C6H16N4O2 MW 176.2 C13H14N4O2 • C4H4O4 MW 374.3 NOC-18 1 mg 15.00 S-NITROSO-L-GLUTATHIONE 5 mg 28.65 159825 [146724-94-9] 5 mg 55.00 159819 [57564-91-7] 10 mg 48.60 o o -20 C (Z-1-[N-(2-Aminoethyl)-N-(2-ammonioethyl)a 10 mg 97.45 0 C (GSNO) 25 mg 65.50 mino]diazen-1-ium-1,2-diolate; 25 mg 194.95 A carrier of nitric oxide (NO), smooth 1-Hydroxy-2-oxo-3,3-bis(3-aminoethyl)-1-tria muscle relaxant and inhibitor of platelet zene) activation. Crystalline Ref.: 1. Gibson, A., et al., Br. J. Pharmacol., A nitric oxide (NO) donor. Half-life time of 107, 715 (1992). NO release at 22°C and pH 7.4 in 0.1 M 2. Radomski, M.W., et al., Br. J. phosphate buffer is > 500 minutes. Pharmacol., 107, 745 (1992). Ref.: 1. Hrabie, J.A., et al., J. Org. Chem., C10H16N4O7S MW 336.3 58, 1472 (1993). 2. Maragos, C.M., et al., Cancer Res., 53, NOC-5 1 mg 28.65 564 (1993). 159820 (1-Hydroxy-2-oxo-3-(3-aminopropyl)-3-isopro 5 mg 126.10 C4H13N5O2 MW 163.2 -20oC pyl-1-triazene) 10 mg 229.30 Crystalline A nitric oxide (NO) donor. Half-life time of NOCODAZOLE NO release at 22 °C and pH 7.4 in 0.1 M See: Methyl[5-(2-Thienylcarbonyl)-1H-Benzimidazol-2- phosphate buffer is 93.0 minutes. yl]Carbamate Ref.: 1. Hrabie, J.A., et al., J. Org. Chem., 58, 1472 (1993). 2. Maragos, C.M., et al., Cancer Res., 53, NODULARIN 500 µg 298.10 564 (1993). 158380 [118399-22-7] o ≥ C6H16N4O2 MW 176.2 0-5 C Purity 98% Potent in the inhibition of protein NOC-7 1 mg 28.65 phosphatases 1 and 2A (PP1 and PP2A) 159821 (1-Hydroxy-2-oxo-3-(N-methylaminopropyl)-3 5 mg 126.10 Useful for affinity purification of PP2A -20oC -methyl-1-triazene) 10 mg 229.30 Similar to Microcystin-LR (ICN Cat. No. Crystalline 158379), but with increased water solubility. A nitric oxide (NO) donor. Half-life time of Ref: 1. J. Cancer Res. Clin. Oncol., 116, NO release at 22 °C and pH 7.4 in 0.1 M 609-614 (1990). phosphate buffer is 10.1 minutes. C41H60N8O10 MW 825 Ref.: 1. Hrabie, J.A., et al., J. Org. Chem., 58, 1472 (1993). NOMIFENSINE 10 mg 16.55 2. Maragos, C.M., et al., Cancer Res., 53, 193699 [32795-47-4] 25 mg 28.65 564 (1993). RT Maleate Salt 100 mg 104.20 C5H14N4O2 MW 162.2 A dopamine uptake inhibitor. C16H18N2 • C4H4O4 MW 354.4 NOC-9 5 mg 55.00 159822 [146724-86-9] 10 mg 97.45 1 mg 28.65 o NOR-1 -20 C (MAHMA-NONOate; 25 mg 194.95 159826 A nitric oxide (NO) donor. Half-life time of 5 mg 126.10 1-Hydroxy-2-oxo-3-(N-methyl-6-aminohexyl)- -20oC NO release at 37 °C and pH 7.4 in 0.1 M 10 mg 229.30 3-methyl-1-triazene) PBS is 1.7 minutes. Crystalline Ref.: Kita, Y., et al., Eur. J. Pharmacol., Purity: ≥98% 257, 123 (1994). A nitric oxide (NO) donor. Half-life time of C8H13N3O5 MW 231.2 NO release at 22 °C and pH 7.4 in 0.1 M phosphate buffer is 2.7 minutes. NOR-2 1 mg 28.65 Ref.: 1. Hrabie, J.A., et al., J. Org. Chem., 159827 A nitric oxide (NO) donor. Half-life time of 5 mg 126.10 58, 1472 (1993). -20oC ° 10 mg 229.30 2. Maragos, C.M., et al., Cancer Res., 53, NO release at 37 C and pH 7.4 in 0.1 M 564 (1993). PBS is 28 minutes. C H N O MW 204.3 Ref.: Kita, Y., et al., Eur. J. Pharmacol., 8 20 4 2 257, 123 (1994). C H N O MW 201.2 NOC-12 1 mg 28.65 7 11 3 4 159823 (1-Hydroxy-2-oxo-3-(N-ethyl-2-aminoethyl)-3 5 mg 126.10 -20oC -ethyl-1-triazene) 10 mg 229.30 NOR-3 1 mg 19.95 159828 (FK409; 5 mg 78.75 Crystalline o A nitric oxide (NO) donor. Half-life time of -20 C (±)-E-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hex 10 mg 115.50 NO release at 22 °C and pH 7.4 in 0.1 M eneamide) phosphate buffer is 327 minutes. A nitric oxide (NO) donor. Half-life time of Ref.: 1. Hrabie, J.A., et al., J. Org. Chem., NO release at 37 °C and pH 7.4 in 0.1 M 58, 1472 (1993). PBS is 30 minutes. 2. Maragos, C.M., et al., Cancer Res., 53, Ref.: Kita, Y., et al., Eur. J. Pharmacol., 564 (1993). 257, 123 (1994). C6H16N4O2 MW 176.2 C8H13N3O4 MW 215.2

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ NOR-4 1 mg 28.65 NORTRIPTYLINE METABOLITE, 1 mg 122.90 159829 A nitric oxide (NO) donor. Half-life time of 5 mg 126.10 153557 (±)-Z-10-HYDROXYLATED 2 mg 202.45 -20oC NO release at 37 °C and pH 7.4 in 0.1 M 10 mg 229.30 RT [37439-87-5] PBS is 60 minutes. ((R,S)-(Z)-3-(10-Hydroxy-10,11-dihydro-5H-d Ref.: Kita, Y., et al., Eur. J. Pharmacol., ibenzo[a,d]cyclohepten- 257, 123 (1994). 5-ylidene)-N-methyl-l-propanamine) C14H18N4O4 MW 306.3 C19H21NO MW 279.4

NORADRENALINE ELISA KIT 1 each 583.00 NOSCAPINE 250 mg 14.45 193594 This noradrenaline ELISA kit provides 153558 [128-62-1] 1 g 43.35 0-5oC materials for the quantitative measurement RT (Narcotine) of chemically derivatized noradrenaline in S(R*,S*)-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro urine. The assay procedure follows the -4-methoxy-6-methyl-1,3-dioxolo[4,5-g]-isoqu basic principle of competitive ELISA inolin-5-yl)-1(3H)-isobenzofuranone whereby there is competition between a C22H23NO7 MW 413.4 biotinylated and non-biotinylated antigen for a fixed number of antibody binding sites. 1 g 18.15 The kit is a 12 x 8 well format. NOVOBIOCIN 155957 [1476-53-5] 5 g 60.15 o FOR RESEARCH USE ONLY! 0-5 C Sodium Salt 25 g 224.35 Purity: ∼90% 100 g 630.65 Crystalline NORDIHYDROGUAIARETIC ACID 500 mg 24.15 Topoisomerase II inhibitor 155944 [500-38-9] 1 g 41.10 C31H35N2O11Na MW 634.6 RT (4,4′-[2,3-Dimethyl-1,4-butanediyl]-bis[1,2-be 5 g 167.80 nzenediol) NPC-14686 200 mg 63.05 Tan Crystals. 159187 Purity: 99% 500 mg 137.60 Inhibitor of lipoxygenases o 0 C Anti-inflammatory agent. 1 g 258.00 C18H22O4 MW 302.4 Ref.: 1. Burch, R.M., Advances in Understanding and Treatment of NORFENTANYL 1 mg 65.60 Rheumatoid Arthritis, Philadelphia, (1991) 158970 Purity: 99% 5 mg 286.65 conference proceedings. RT Urinary metabolite of fentanyl. 10 mg 544.65 MW 401.4 Ref.: Hammargren, W.R. and Henderson, G.L., J. Anal. Toxicol., 12, 183 (1988). 1 mg 32.05 MW 232.3 NS-398 159981 [123653-11-2] 5 mg 145.65 RT Purity: 98% 10 mg 252.25 DL-NORMETANEPHRINE 100 mg 12.50 Specific inhibitor of PGH synthase-2. 105174 [1011-74-1] 250 mg 30.00 Ref.: Futaki, N., et al., Prostaglandins, 47, RT (DL-α-[Aminomethyl]-4-hydroxy-3-methoxybe 500 mg 58.10 55 (1994). nzenemethanol) 1 g 115.70 MW 314.4 Hydrochloride 5 g 566.55 Crystalline ∼ NUCLEAR YELLOW 25 mg 39.30 Purity: 98% 155959 100 mg 137.60 C H NO • HCl MW 219.7 [74681-68-8] 9 13 3 RT (2-[4-Sulfamylphenyl]-6-[6-(4-methylpiperazin 250 mg 321.05 o)-2-benzimidazolyl]benzimidazole NORMETANEPHRINE ELISA KIT 1 each 545.75 trihydrochloride) 193595 This normetanephrine ELISA kit provides Dye content: Approx. 80% 0-5oC materials for the quantitative measurement A fluorescent neuronal tracer. of chemically derivatized normetanephrine Ref.: 1. Bentivoglio, M., et. al., Neurosci. in urine. The assay procedure follows the Lett., 18, 25 (1980). 2. Kuypers, H.G.J.M. basic principle of competitive ELISA and Huisman, A.M., Adv. Cellular whereby there is competition between a Neurobiol., 5, 307 (1984). biotinylated and a non-biotinylated antigen C25H25N7O2S • 3HCl MW 597 for a fixed number of antibody binding sites. The kit is a 12 x 8 well format. NYLIDRIN 1 g 10.20 FOR RESEARCH USE ONLY! 155963 [849-55-8] 5 g 37.50 RT Hydrochloride 10 g 70.25 Purity: 95% 25 g 170.50 1-NOROKADAONE 50 µg 197.65 β-Adrenergic receptor agonist µ 158381 [131204-29-0] 100 g 375.50 C19H25NO2 • HCl MW 335.9 0-5oC Purity ≥ 98% Serine/Threonine Phosphatase Inhibitor. Possible okadaic acid negative control. -O- C43H66O11 MW 758.99 1-O-OCTADECYL-2-O-ACETYL-sn-GLYCERO-1- NORTRIPTYLINE 250 mg 21.75 PHOSPHORYLCHOLINE 153555 [894-71-3] 1 g 43.35 RT (3-(10,11-Dihydro-5H-dibenzo[a,d]-cyclohept See: L-α-Phosphatidylcholine-β-Acetyl-γ-O-Octadecyl en-5-ylidene)-N-methyl-1-propanamine) Hydrochloride 3-(4-OCTADECYL)- 10 mg 88.20 A norepinephrine uptake inhibitor. • 159016 BENZOYLACRYLIC ACID 25 mg 195.00 C19H21N HCl MW 299.8 RT (OBAA) 50 mg 364.05 Purity: 98% NORTRIPTYLINE METABOLITE, 1 mg 122.90 Strongly blocks snake venom PLA2. Also 153556 (±)-E-10-HYDROXYLATED 2 mg 202.45 demonstates inhibition of allergen induced RT [37439-89-7] bronchospasm. ((R,S)-(E)-3-(10-Hydroxy-10,11-dihydro-5H-d Ref 1. Kohler, T., et.al., Agents Actions, ibenzo[a,d]cyclohepten- 32,144 (1991). 2. Madi, S., et.al., ibid., 32, 5-ylidene)-N-methyl-l-propanamine) 144 (1991). C19H21NO MW 279.4 C28H44O3 MW 428.4

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 1-O-OCTADECYL-sn-GLYCERO-3- 5 mg 54.45 OCTYLONIUM BROMIDE 5 mg 108.95 159188 PHOSPHORYLCHOLINE 10 mg 103.45 159190 [26095-59-0] 10 mg 200.65 -20oC [74430-89-0] 25 mg 255.60 0oC Purity: 98% 25 mg 452.90 (Lyso-PAF c-18) Exhibits high affinity for platelet PAF Purity: 99% receptors. Useful clinical spasmolytic agent Inactive platelet activating factor metabolite. for increased muscle tone. Ref.: Wykle, R.L., et.al., Biochem. Biophys. Ref.: 1. Ortega, M.P., et.al., J. Pharmacol. Res. Commun., 100, 1651 (1981). Exp. Ther., 255, 28 (1990). 2. Whatley, MW 509.7 R.E., et.al., Prostaglandins, 43, 21 (1992). 3. Mudler, H.W., et.al., Biochem. Bhiphys. 1-O-OCTADECYL-2-O-METHYL-sn- 1 mg 39.80 Res. Commun., 176, 1557 (1991). 191509 GLYCERO-3 PHOSPHORYLCHOLINE 5 mg 75.50 MW 563.6 0oC Inhibits protein kinase C from various 10 mg 143.15 leukemia cells. Displays antineoplastic ODQ activity. See: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one Ref.: (1) D.M. Helfman, et al., Cancer Res., 43, 2955 (1983). µ 212.85 MW 523.7 OKADAIC ACID 100 g 193514 [78111-17-8] 300 µg 583.95 0-5oC Free Acid 4-(4-OCTADECYL)-4- 5 mg 45.10 Purity ≥ 98% 159635 25 mg 182.40 o OXOBENZENEBUTENOIC ACID Potent inhibitor of serine/threonine-specific 0-5 C Phospholipase A2 inhibitor protein phosphatases 1 and 2A (PP1 and C28H44O3 MW 428.6 PP2A) and of 2B at higher concentrations. Does not inhibit protein tyrosine 17-OCTADECYNOIC ACID 1 mg 21.20 phosphatases or kinases which have been 159189 [34450-18-5] 5 mg 97.45 o tested. 0 C (17-ODYA) 10 mg 172.00 C44H68O13 MW 805.01 Free Acid Purity: 99% OKADAIC ACID 10 µg 33.85 Specifically inhibits LTB4 ω-oxidase. 158973 [78111-17-8] 25 µg 60.70 o Ref.: Shak, S., et.al., J. Biol. Chem., 260, -20-0 C Potassium Salt 50 µg 98.55 13023 (1985). Purity: ≥98% 100 µg 166.80 C18H32O2 MW 280.4 C44H67KO13 MW 843.1

N-OCTANOYL-D-erythro- 50 µCi 726.45 OKADAIC ACID 10 µg 40.40 16024 14 158974 Sodium Salt 25 µg 81.40 SPHINGOSINE [Octanoyl-1- C] o 0-5oC Sp. Act. 25-50 mCi/mmol -20-0 C Purity: ≥98% 50 µg 135.50 0.925-1.85 GBq/mmol C44H67O13Na MW 828 100 µg 265.10 Ethanol solution. Please call for delivery information. OKADAIC ACID, 7-O-PALMITOYL MW 397.5 See: 7-O-Palmitoylokadaic acid N-OCTANOYL-D-erythro- 50 µCi 726.45 26041 SPHINGOSINE [Octanoyl-1-3H] OKADAIC ACID 7,10,24,28- 50 µg 83.70 o 158384 100 µg 157.80 0-5 C Sp. Act. 5-10 Ci/mmol o TETRAACETATE 1.85-3.70 GBq/mmol 0-5 C [78111-15-6] Ethanol solution. Purity ≥ 98% Please call for delivery information. Serine/Threonine protein phosphatase MW 397.5 inhibitor C52H76O17 MW 973.16 OCTOCLOTHEPIN 10 mg 23.15 OKADAOL 50 µg 135.00 193701 [4789-68-8] 50 mg 94.80 µ RT Maleate Salt 158385 [131959-12-1] 100 g 260.00 0-5oC Purity ≥ 98% A D2 dopamine and serotonin receptor antagonist. Okadaic acid analog C H N SCl • C H O MW 461.0 Serine/Threonine protein phosphatase 19 21 2 4 4 4 inhibitor. C44H70O12 MW 791.03 DL-OCTOPAMINE 1 g 6.85 150143 [770-05-8] 5 g 18.30 (±)-1-OLEOYL-2-ACETYLGLYCEROL 5 mg 53.35 RT [DL-1-(p-Hydroxyphenyl)-2-aminoethanol] 10 g 35.80 191510 [92282-11-6] 10 mg 91.75 Hydrochloride 50 g 173.80 -20oC Purity: 98% 25 mg 192.05 Crystalline Potent, membrane-permeable activator of 50 mg 375.00 Sympathomimetic protein kinase C. C8H11NO2 • HCl MW 189.6 C23H42O5 MW 398.6 (+)-7-OCTYLINDOLACTAM V 1 mg 311.40 OLEYLOXYETHYL 10 mg 57.35 158971 [123597-54-6] o 159015 PHOSPHORYLCHOLINE 25 mg 131.90 -20-0 C Purity: 99% 0oC Purity: 98% 50 mg 252.25 Inactive isomer used as a negative control. Specifically inhibits PLA2. C26H37N3O2 MW 423.6 Ref.: 1. Mayolda, R.L., et.al., Prostaglandins, Leukotrienes, and Lipoxins, (-)-7-OCTYLINDOLACTAM V 1 mg 172.00 (J.M. Bailey, ed.), Plenum, N.Y., 669 (1985). 158972 [109346-66-9] 5 mg 785.40 o 2. Kauser, K., et.al., Circulation Res., 68, -20-0 C Purity: 99% 1154 (1991). Analog of teleocidin which is a non-phorbol MW 477.7 activator of protein kinase C. It has higher potency and metabolic stability. OLIGOMYCIN 1 mg 20.80 Ref.: 1. Fujiki, H. and Sugimura, T., Adv. 151786 [1404-19-9] 5 mg 55.05 Cancer Res., 49, 223 (1987). 2. Collins, M. 0-5oC A mixture of oligomycin A, B, and C in 10 mg 104.20 and Rozengurt, E., Biochem. Biophys. Res. approx. ratio 60:30:10 Commun., 104, 1159 (1982). Antibiotic that inhibits respiration in C26H37N3O2 MW 423.6 mitochondria

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ OLIGOMYCIN A 1 mg 20.25 1H-[1,2,4]OXADIAZOLO[4,3-a]- 5 mg 40.95 151783 [579-13-5] 5 mg 49.25 193702 QUINOXALIN-1-ONE 25 mg 187.00 0-5oC (Olivomycin) 0-5oC (ODQ) From Streptomyces olivoreticuli A potent, selective inhibitor of NO-sensitive m.p. 140-141°C guanylyl cyclase. Reportedly inhibits growth of Aspergillus Ref.: Boulton, et al., Neuroscience, 69, 699 niger and other moulds. (1995). Ref.: Nakakita, V., et al., J. Antibiot., 33, C9H5N3O2 MW 187.2 514 (1980). C45H74O11 MW 791.1 4-OXATETRADECANOIC ACID 1 mg 29.80 159806 Inhibits HIV replication. 5 mg 90.55 OLIGOMYCIN B 1 mg 111.35 0-5oC Ref.: Langer, C.A., et al., J. Biol. Chem., 10 mg 146.20 151784 [11050-94-5] 5 mg 421.00 267, 17159 (1992). o 0-5 C Crystalline C13H26O3 MW 230.3 C45H72O12 MW 805.1 20-OXO-20-DEOXYPHORBOL 12,13- 1 mg 135.15 159639 5 mg 546.00 OLIGOMYCIN C 1 mg 80.30 o DIBUTYRATE 151785 [11052-72-5] 5 mg 364.55 0 C [100930-03-8] 0-5oC Crystalline Purity: 98% Antibiotic For the preparation of tritiated Phorbol C28H46O6 MW 478.7 12,13-dibutyrate C28H38O8 MW 502.6 OLOMOUCINE 1 mg 18.35 159805 [101622-51-9] 5 mg 71.10 20-OXO-20-DEOXYPHORBOL 12- 1 mg 125.05 o 159640 5 mg 510.35 -20 C (6-Benzylamino-2-(2-hydroxyethylamino)-9-m 25 mg 282.10 o MYRISTATE 13-ACETATE ethylpurine) 0 C [30358-69-1] Purity: 99% Purity: 98% Selective inhibitor of cdc2, cdk and other For the preparation of tritiated PMA cyclin-related kinases. C36H54O8 MW 614.8 C H N O MW 298.4 15 18 6 20-OXO-12,20-DIDEOXYPHORBOL 13- 1 mg 169.75 159642 ISOBUTYRATE 5 mg 655.00 OPHIOBOLIN A 1 mg 65.35 o 159636 [4611-05-6] 5 mg 261.40 0 C [123597-58-0] 0-5oC (Cochliobolin A) Purity: 98% From Helminthosporium sp. Used to prepare tritiated 12-Deoxyphorbol Purity: 95+% 13-isobutyrate Calmodulin inhibitor C24H32O6 MW 416.5 Ref.: Leung, P.C., et al., Int. J. Biochem., 20, 1351 (1988). 20-OXO-12,20-DIDEOXYPHORBOL 13- 1 mg 175.50 159643 5 mg 692.20 C25H36O4 MW 400.6 PHENYLACETATE 0oC [138574-84-2] OPOSSUM SERUM 1 ml 78.00 Purity: 98% 2942000 From Didelphis virginia For the preparation of tritiated -20oC A rare animal sera suitable for eukaryotic 12-Deoxyphorbol 13-phenylacetate cultures. Ideal for neuroscience C23H32O6 MW 464.6 investigations. OXOTREMORINE METHIODIDE 25 mg 26.10 153610 (Oxotremorine M) 50 mg 47.05 D 1 g 13.50 o -ORNITHINE 0-5 C C11H19IN2O MW 322.2 100 mg 86.75 102514 [16682-12-5] 5 g 47.25 RT (D-2,5-Diaminopentanoic acid) 10 g 85.95 OXOTREMORINE SESQUIFUMARATE 25 mg 10.90 Hydrochloride 153609 [17360-35-9] 50 mg 17.35 Crystalline o ∼ 0-5 C (1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinon 100 mg 28.85 Purity: 99% e sesquifumarate) C5H12N2O2 • HCl MW 168.6 C12H18N2O • 3/2C4H4O4 MW 380.4 L-ORNITHINE 5 g 6.10 OXYMETAZOLINE 5 g 30.65 100421 [3184-13-2] 25 g 12.65 190255 [1491-59-4] 10 g 54.20 RT (L-2,5-Diaminopentanoic acid) 100 g 31.60 RT (2-[3-Hydroxy-2,6-dimethyl-4-t-butyl-benzyl]-2 25 g 117.65 Hydrochloride 1 kg 212.10 -imidazoline) 100 g 327.40 Crystalline 5 kg 1015.20 ∼ Hydrochloride Purity: 99% Crystalline This material is essentially free of citrulline Adrenergic compound and ammonia. C16H24N2O • HCl MW 296.8 C5H12N2O2 • HCl MW 168.6

14 OXYTOCIN 100 ml 9.85 L-ORNITHINE [ C(U)] 10 µCi 411.10 100896 [50-56-6] 1 liter 80.55 16012 Sp. Act. >250 mCi/mmol 50 µCi 908.35 o α o -20-0 C ( -Hypophamine; 5 liter 390.15 0-5 C >9.25 GBq/mmol Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2) 0.01N HCl solution. Contains Cys1-Cys6 disulfide bond. Please call for delivery information. In 0.25% acetic acid with 0.5 % NH2(CH2)3CH(NH2)COOH MW 132.1 chlorobutanol as preservative. Activity: ∼20 units/cc OUABAIN 250 mg 19.30 C43H66N12O12S2 MW 1007.2 102541 [630-60-4] 1 g 47.25 0-5oC (G-Strophanthin) 5 g 181.35 OXYTOCIN 500IU 47.70 Crystalline 25 g 707.90 191057 [50-56-6] 1000IU 84.50 Octahydrate -20-0oC (α-Hypophamine; 5000IU 351.85 An inhibitor of Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2) sodium-potassium-ion-dependent ATPase. Contains Cys1-Cys6 disulfide bond. Ref.: J. Pharmacol. Exp. Ther., 189, 434 Lyophilized white powder. (1974). Activity: ∼500 I.U./mg • C29H44O12 8H2O MW 728.8 C43H66N12O12S2 MW 1007.2

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ [Thr4,Gly7]-OXYTOCIN 0.5 mg 20.00 PAPAVERINE 5 g 13.40 152959 [60786-59-6] 1 mg 31.70 190261 [61-25-6] 25 g 41.75 o -20-0 C (Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2) 5 mg 138.00 RT (6,7-Dimethoxy-1-veratrylisoquinoline) 100 g 117.50 Contains disulfide bond between Cys1 and Hydrochloride Cys6. Crystalline A selective oxytocin agonist. Purity: ∼99% Ref: Lowbridge, J., et al., J. Med. Chem., Phosphodiesterase inhibitor 20, 120 (1977). C20H21NO4 • HCl MW 375.9 C39H61N11O12S2 MW 940.1 PARGYLINE 500 mg 16.15 -P- 195366 [306-07-0] 1 g 27.30 p53 ONCOPROTEIN 0.25 ml 242.55 0oC (N-Methyl-N-propargylbenzylamine; 5 g 115.70 692461 POLYCLONAL ANTIBODY N-Methyl-N-α-propynylbenzylamine) 0-5oC Anti-Human p53 Hydrochloride Host: rabbit Crystalline Form: purified antiserum Purity: 99% Conc/Titer: 1:50-1:100 Inhibits MAO. Potential for treating Applications: immunopreciptin; hypertension. immunohistology; frozen and Not for use in humans. paraffin-embedded sections C11H13N • HCl MW 195.7 This antibody reacts with wild type and most mutant forms of p53. PARTHENOLIDE 25 mg 61.85 PACLITAXEL 1 mg 13.65 159988 [20554-84-1] 50 mg 98.15 193532 [33069-62-4] 5 mg 43.80 -20oC Purity: 97% 0-5oC (Taxol) 25 mg 156.50 Demonstrates anti-inflammatory, From the Pacific Yew Tree 100 mg 425.00 anti-secretory, and spasmolytic activity. Taxus brevifolia Sesquiterpene lactone from Antitumor agent which lowers the critical Chrysanthemem parthenium used as a concentration for tubulin polymerization and herbal remedy for migrane headaches and reversibly binds to tubulin prohibiting arthritis. depolymerization. Ref.: 1. Barsby, R.W., et al., J. Biol. Purity: >98% Pharmacol., 44, 737 (1992). C47H51NO14 MW 853.9 2. Sumner, H., et al., Biochem. Pharmacol., µ 258.00 43, 2313 (1992). 7-O-PALMITOYLOKADAIC ACID 25 g C H O MW 248.3 159644 Purity: ∼90-94% 15 20 3 o 0 C C60H98O14 MW 1043.4 PATULIN 2 mg 43.00 N-PALMITOYL-D-SPHINGOSINE 1 mg 33.85 159989 [149-29-1] 5 mg 77.00 158975 [24696-26-2] 5 mg 137.20 o o -20 C A mycotoxin which blocks the farnesylation 10 mg 122.00 -20-0 C (N-Hexadecanoyl-D-sphingosine; C16 25 mg 613.40 of proteins in a cell free assay. It inhibits the ceramide; palmitoyl ceramide) incorporation of 3H-mevalonate into Purity: 98% proteins found in complete cells. Stimulates cytosolic serine/threonine Ref.: Miura, S., et al., FEBS Lett, 318, 88 protein phosphatase in T9 cells. Induces (1993). phosphorylation on Thr-669 in A-431 cells. POSSIBLE CARCINOGEN! Ref.: 1. Dobrowsky, R.T. and Hannum, Y.A., C H O MW 154.1 et al., J. Biol. Chem., 267, 5048 (1992). 2. 7 6 4 Mathias, S., et al., Proc. Natl. Acad. Sci. USA, 88, 10009 (1991). PAXILLIN C34H67NO3 MW 537.9 MONOCLONAL ANTIBODY N-PALMITOYL-D-SPHINGOSINE, 50 µCi 1211.55 Anti-Human 16013 [Palmitoyl-1-14C] Clone: 349 0-5oC Sp. Act. 50-60 mCi/mmol Isotype: purified Ig fraction from mouse ascites 1.85-2.22 GBq/mmol Conc/Titer: 1:1,000-1:5,000 Ethanol solution. Applications: Immunoblotting; Immunoprecipitation Please call for delivery information. Paxillin localizes to the focal adhesions at the ends of actin stress MW 537.9 fibers in chicken embryo fibroblasts. It is present in the focal adhesions of the Madin-Darby bovine kidney epithelial cells but is PALMITYLETHANOLAMIDE 10 mg 57.35 absent from cell-cell adherens junctions of these cells. When 159986 Purity: 98% 25 mg 120.40 purified from chicken gizard, it migrates as a diffuse band on o -20 C Negative control for anandamide. SDS-PAGE with Mr of 65-70 kDa and exists insmultiple isoforms. Ref.: Devane, W.A., et al., Science, 258, The antibody is packaged at a concentration of 1 mg/ml in 50% 1946 (1992). glycerol, 5mM TRIS, pH 8.2, 25mM NaCl, 1.5mM NaN3. MW 299.5 696002 50 µg 299.00 PALYTOXIN 10 µg 177.70 696001 100 µg 395.00 158976 [77734-91-9] 25 µg 362.25 o -20-0 C Purity: 98% 50 µg 700.20 Non-peptide toxin from various species of 100 µg 1216.30 PAXILLINE 1 mg 33.05 Palythoa. Potently activates 193944 [57186-25-1] 5 mg 61.40 tetrodotoxin-insensitive Na+ channels. -20oC From Penicillium paxilli Stimulates the release of catecholamine This fungal mycotoxin possess potent and the metabolism of arachidonic acid. It excitatory action on acetylcholine release does not compete for the TPA receptor. from nerve terminals. It specifically inhibits Ref.: 1. Beress, L., et al., Toxicology, 21, smooth muscle high conductance 285 (1983). 2. Muramatsu, I., et al., J. Ca2+-activated K+ channels, as well as, Pharmacol. Exp. Ther., 231, 488 (1984). 3. enhances [125]-charybotoxin binding to Nakanishi, A., et al., Neurosci. Lett., 121, these channels. 163 (1991). 4. Lazzaro, M., et al., Ref.: Knaus, et al., Biochemistry, 33, 5819 Endocrinology, 120, 1338 (1987). 5. Levine, (1994). L., et al., Prostaglandins, 31, 669 (1986). MW 435.6 C129H223N3O54 MW 2677.4 To place an order: (800) 854-0530, fax (800) 334-6999 1206 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ PCO-400 20 mg 63.00 PERILLIC ACID 100 mg 35.60 198594 [121055-10-5] 100 mg 229.70 159029 [7694-45-3] 500 mg 160.00 RT ([-]-(3S,4R)-3,4-Dihydro-3-hydroxy-2,2-dimet 0oC Purity: 95% hyl-4-(3-oxo-cyclopent-1-enyl-2-oxy)-2H-1-be Inhibitor of isoprenylation of p21ras and nzypyran-6-carbonitrile) other small G proteins. Potassium channel opener. Ref.: Crowell, P.L., et al., J. Biol. Chem., Purity: >95% 266, 17679 (1991). C17H17NO4 MW 299.3 MW 166.2

PENITREM A 1 mg 27.70 PERMETHRIN 10 mg 53.70 158977 [52645-53-1] 25 mg 117.55 193945 [12627-35-9] o -20oC (Tremortin A) 0-5 C Mixture of isomers 50 mg 213.85 From Penicillium palitans A weakly active Type I pyrethrin for use as A tremorgenic fungal mycotoxin which a "negative" control for the inhibition of increases GABA release and aspartate calcineurin (protein phosphatase 2B) by from cerebrocortical synaptosomes and Type II pyrethrins. acetylcholine in rat neuromuscular junction. C21H20O3Cl2 MW 391.29 Ref.: Wilson, et al., Brain Res., 40, 540 (1972). PEROXYNITRITE 1 mg 68.25 C37H44NO6Cl MW 634.2 196033 Tetramethylammonium Salt 5 mg 294.00 -20oC Purity: ∼90% A novel new reactive oxygen species PENTOXIFYLLINE 10 g 19.75 (ROS) created from nitric oxide and 156107 [6493-05-6] 100 g 134.85 superoxide shown to be directly involved in RT (Trental) 250 g 295.80 apoptosis, cancer, stroke, heart and Phosphodiesterase inhibitor. Also blocks α Alzheimer’s disease. synthesis of Tumor Necrosis Factor- . This product contains no nitrite, nitrate, C13H18N4O3 MW 278.3 metal ions or hydrogen peroxide contaminants and rapidly decomposes in PENTYLENETETRAZOLE 1 g 10.90 the presence of moisture. 153552 [54-95-5] 5 g 32.55 NO3 • (CH3)4N MW 127.08 RT (Metrazole; 6,7,8,9-Tetrahydro-5H-tetrazolo- PERTUSSIS TOXIN 50 µg 302.30 [1,5-a]azepine) 150014 [70323-44-3] o C6H10N4 MW 138.2 0 C Islet-Activating Protein isolated from Bordetella pertussis. µ α 10 mg 63.05 Lyophilized powder, containing 50 g -PENTYL-3-(2-QUINOLINYL- protein in 0.01 M sodium phosphate buffer, 159191 METHOXY)BENZENEMETHANOL 25 mg 137.60 RT 50 mg 258.00 pH 7.0, and 0.05 M sodium chloride. Each (REV-5901) vial should be reconstituted with 500 µl of Purity: 98% sterile distilled water, and the resulting Leukotriene D4 antagonist and suspension made uniform by gentle mixing. 5-lipoxygenase inhibitor. Do not sterile filter, since loss of material Ref.: 1. Vanlnwegen, R.G., et al., J. will result. Pharmacol. Exp. Ther., 241, 117 (1987). 2. Coutts, S.M., et al., In Prostaglandins µ Leukotrienes and Lipoxins (Plenum, NY) PERTUSSIS TOXIN 50 g 286.65 152296 [70323-44-3] (1985), p.626. 3. Kusner, E.J., et al., o Biochem. Pharmacol., 38, 4283 (1989). 0 C Islet-Activating Protein isolated from 335.4 Bordetella pertussis. Pure, lyophilized powder containing no buffer salts. Dissolves completely when reconstituted α-PENTYL-4-(2-QUINOLINYL- 10 mg 74.55 with sterile distilled water. Purity checked by 159192 METHOXY)BENZENEMETHANOL 25 mg 172.00 SDS-PAGE and biological activity tested by RT (L-655,238 CREV 5901, para isomer) 50 mg 315.30 lipolysis-promoting activity on rat Purity: 98% adipocytes. This is a sterilized product, and Specifically and strongly blocks may be used in cell-culture applications 5-LO-activating protein (FLAP). without pretreatment. Ref.: Evans, J.F., et al., Mol. Pharmacol., 40, 22 (1991). PERTUSSIS TOXIN A PROTOMER 10 µg 326.75 159035 From Bordatella pertussis 0-5oC Purity: 99% PEPSTATIN A 1 mg 11.45 + 195368 [26305-03-3] 5 mg 25.25 Demonstrates NAD glycohydrolase activity -20oC ((Isoval-Val-Val-Sta-Ala-Sta) 10 mg 47.10 and ADP-ribosyltransferase activity. Like Sta = statine = 25 mg 77.25 native pertussis toxin, it catalyzes (3S,4S)-4-amino-3-hydroxy-6-methylheptano 100 mg 256.00 ADP-ribosylation in broken cell preparations. ic acid. 250 mg 485.95 Ref.: 1. Kopf, G.S. and Woolkalis, M.J., Synthetic Methods Enzymol., 195, 257 (1991). 2. Inhibitor for pepsin, renin, cathepsin D, and Tamura, M., et al., Biochemistry, 21, 5516 other acid proteases. (1982). Ref.: 1. Umezawa, H., et al., J. Antibiot., 23, 259 (1970). PERTUSSIS TOXIN B OLIGOMER 40 µg 452.90 159034 From Bordetella perussis 2. Lazar, J., et al., Biochem. Pharmac., 23, o 2776 (1974). 0-5 C Responsible for the attachment of the C34H63N5O9 MW 685.9 native form to eukaryotic cell surfaces. Also assists in the translocation of protomer A. It demonstrates T-cell mitogenesis in humans PERHEXILINE 1 g 21.25 and helps platelet aggregation. 151814 [6724-53-4] 5 g 70.40 Ref.: 1. Tamura, M., et al., Biochemistry, RT (2-[2,2-Dicyclohexylethyl]piperidine) 10 g 139.60 21, 5516 (1982). 2. Strand, C.F. and Maleate Salt Carchman, R.A., FEBS Lett., 225, 16 A calcium blocking agent • (1987). 3. Tamura, M., et al., ibid., 258, C19H35N C4H4O4 MW 393.6 6756 (1983)

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ PHACLOFEN 10 mg 191.60 N-PHENYLANTHRANILIC ACID 500 mg 22.05 153797 [114012-12-3] 15 mg 273.35 193703 [91-40-7] 1 g 39.70 RT (3-Amino-2-(4-chlorophenyl) 25 mg 433.80 RT (Diphenylamine-2-carboxylic acid; DPC) propylphosphonic acid) A Cl- channel blocker. Selective GABAB antagonist. C13H11NO2 MW 213.2 C9H13CINO3P MW 249.6 1-PHENYLBIGUANIDE 250 mg 21.75 PHALLOIDIN 1 mg 206.35 153568 [102-02-3] 1 g 43.35 159990 [17466-45-4] RT (N-Phenyl-imidocarbonimidic diamide) o -20 C From Amanita phalloides 5-HT3 serotonin agonist Purity: >95% C8H11N5 MW 177.2 Potently and specifically inhibits the conversion of F-actin to G-actin. PHENYLBUTAZONE 25 g 56.60 Ref.: Cooper, J.A., J. Biol. Chem., 105, 153567 [50-33-9] 100 g 180.55 1473 (1987). RT (4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione) C35H48N8O11S MW 788.9 C19H20N2O2 MW 308.4

PHE-MET-ARG-D-PHE AMIDE 1 mg 28.65 cis-N-(2-PHENYLCYCLOPENTYL)- 1 mg 10.50 159992 [84413-35-4] 196047 AZACYCLOTRIDEC-1-EN-2-AMINE 5 mg 34.15 0oC Purity: 97% 0-5oC [40297-09-4] 25 mg 131.50 4 [D-Phe ]-Molluscan Cardioexcitatory (MDL-12330A) Neuropeptide analog. Hydrochloride Ref.: Mues, G., et al., Life Sci., 31, 2555 Purity: ≥98% (1982). Inhibits adenylate cyclase. C29H42N8O4S MW 598.8 Ref.: Ferretti, M.E., et al., Neurosci. Lett., 207(3), 191-194 (1996). D-PHE-MET-ARG-PHE AMIDE 1 mg 26.65 C23H36N2 MW 377.0 159994 [84313-42-8] 0oC Purity: 97% 250 mg 28.85 1 trans-2-PHENYLCYCLOPROPYL- [D-Phe ]-Molluscan Cardioexcitatory 153566 AMINE 1 g 71.80 Neuropeptide analog. RT [95-62-5] Ref.: Mues, G., et al., Life Sci., 31, 2555 (Tranylcypromine) (1982). Hydrochloride C29H42N8O4S MW 598.8 Monoamine Oxidase inhibitor C H N • HCl MW 169.7 PHE-MET-ARG-PHE AMIDE 0.5 mg 28.25 9 11 153163 [64190-70-1] 1 mg 42.70 o trans-2-PHENYLCYCLOPROPYL- 1 g 16.10 -20-0 C (Molluscan Cardioexcitatory Neuropeptide) 5 mg 119.30 156170 AMINE 5 g 80.00 Ref: 1. Price, D. and Greenberg, M.J., 0-5oC [13492-01-8] 25 g 395.20 Science, 197, 670 (1977). (Tranylcypromine) 2. Greenberg, M.J., et al., Neuropeptides, Hemisulfate Salt 1, 309 (1981). Monoamine Oxidase inhibitor C29H42N8O4S MW 598.8 C9H11N • 1/2H2SO4 MW 182.2 1 mg 21.80 PHENAMIL DL-threo-1-PHENYL-2-DECANOYL- 10 mg 55.00 159807 [2038-35-9] 5 mg 87.15 o 158978 AMINO-3-MORPHOLINO-1- 25 mg 131.90 0-5 C (3,5-Diamino-6-chloro-N-[imino(phenylamino 0oC 50 mg 252.25 )methyl]-pyrazinecarboxamide) PROPANOL An amiloride analog which irreversibly (DL-PDMP) blocks amiloride-sensitive sodium channels. Purity: 98% C H N OCl MW 305.7 Blocks the glucosylation of ceramide by 12 12 7 inhibiting UDP-glucose: ceramide 6(5H)-PHENANTHRIDINONE 50 mg 23.10 glucosyltransferase. Inhibits cell surface 196028 [1015-89-0] 200 mg 73.50 glycolipid antigen expression and the RT (PARP Inhibitor) growth of rabbit skin cultures. Also, Purity: ≥98% demonstrates antitumor activity. Displays immunosuppressive activity. Ref.: 1. Vunnam, R.R. and Radin, N.R., Inhibits concanavalin A-induced lymphocyte Chem. Phys. Lipid., 26, 265 (1980). proliferation at micromolar concentrations. 2.Inokuchi, J.-I., et al., J. Cell Physiol., 141, MW 195.2 573 (1989). 3. Uemura, K.-I., et al., J. Biochem., 108, 525 (1990). 4. Inokuchi, PHENOXYBENZAMINE 250 mg 161.40 J.-I., et al., Cancer Lett., 38, 23 (1987). 151821 [63-92-3] 0-5oC (Benzene methanamine) L-PHENYLEPHRINE 1 g 11.20 Hydrochloride 195380 [61-76-7] 5 g 17.80 Selective α-adrenergic blocking agent. RT Hydrochloride 10 g 28.15 Purity: 99% 25 g 54.40 Irreversible calmodulin inhibitor. α C18H22NO • HCl MW 340.3 1-adrenergic agonist 50 g 88.35 C9H13NO2 • HCl MW 203.7 100 g 152.75 PHENTOLAMINE MESYLATE 25 mg 13.00 6 153795 [65-28-1] 50 mg 21.75 N -(2-PHENYLETHYL)- 10 mg 45.55 153793 15 mg 65.10 RT (REGITIN) 100 mg 39.80 o ADENOSINE (3-[[(4,5-Dihydro-1H-imidazol-2- 0-5 C [20125-39-7] 25 mg 101.25 yl)methyl](4-methylphenyl)- A1 adenosine receptor agonist amino]phenol mesylate) C18H21N5O4 MW 371.4 C17H19N3O • CH3SO3H MW 377.5 PHENYLETHYL CAFFEATE 10 mg 19.85 N6-PHENYLADENOSINE 10 mg 45.55 193775 [104594-70-9] 25 mg 36.40 o 153796 A1 adenosine receptor agonist 15 mg 50.60 0-5 C (Phenethyl caffeate) 50 mg 51.80 o 0-5 C C16H17N5O4 MW 343.3 25 mg 65.10 A cytotoxic agent to cancer cell lines. Acts 100 mg 71.65 as an inhibitor of protein tyrosine kinase 2-PHENYLAMINOADENOSINE 10 mg 70.00 and ornithine decarboxylase. 153794 [53296-10-9] 15 mg 98.00 Ref.: Rao, C.V., et al., Chem. Biol. o -20-0 C A2 adenosine agonist 25 mg 157.00 Interactions, 84, 277-90 (1992). C16H18N6O4 MW 358.4 C17H16O4 MW 284.3

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ PHENYLETHYL DIMETHYL 10 mg 18.75 S-[N-(3-PHENYLPROPYL)- 50 mg 66.65 193776 CAFFEATE 25 mg 35.30 159996 THIOCARBAMOYL]-L-CYSTEINE 100 mg 100.20 0-5oC [14551-14-0] 50 mg 47.40 -20oC [137915-13-0] 500 mg 421.20 (Phenethyl dimethyl caffeate) 100 mg 60.65 Purity: 98% Inhibitor of protein tyrosine kinase and Glutathione S-transferase inducer and ornithine decarboxylase. chemical carcinogenesis inhibitor. Ref.: Rao, C.V., et al., Chem. Biol. Ref.: Zheng, G.-Q., et al., J. Med. Chem., Interactions, 84, 277-90 (1992). 35, 185 (1992). C19H20O4 MW 312.4 C13H18N2O2S2 MW 298.4

N-(6-PHENYLHEXYL)-5-CHLORO-1-NAPHTHALENE- 8-PHENYLTHEOPHYLLINE 25 mg 53.00 151846 [961-45-5] 100 mg 125.90 SULFONAMIDE RT Crystalline 500 mg 254.05 See: 5-Chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide A potent antagonist of adenosine-mediated accumulation of cAMP in a human 6 10 mg 38.35 fibroblast cell line. R-(-)-N -(2-PHENYL- Life Sci., , 2475 (1979). 153784 ISOPROPYL)ADENOSINE 15 mg 54.70 Ref.: 24 o C H N O MW 256.3 0-5 C [38594-96-6] 25 mg 86.75 13 12 4 2 (R(-)-PIA) 1-PHENYL-3-(2-THIAZOLYL)-2- 250 mg 26.15 A1 adenosine receptor agonist C H N O MW 385.4 156206 THIOUREA 1 g 73.60 19 23 5 4 RT [14901-16-7] 6 10 mg 38.35 Crystalline S(+)-N -(2-PHENYL- A dopamine β-hydroxylase inhibitor. 153783 ISOPROPYL)ADENOSINE 15 mg 54.70 o Ref.: J. Pharmacol. Exp. Ther., 171, 80 0-5 C [38594-97-7] 25 mg 86.75 (1970). C19H23N5O4 MW 385.4 C10H9N3S2 MW 235.3 L-β-PHENYLLACTIC ACID 500 mg 14.35 17-PHENYL-TRINOR- 1 mg 68.75 151838 [20312-36-1] 1 g 26.20 159194 PROSTAGLANDIN E2 5 mg 315.30 RT (L-2-Hydroxy-3-phenylpropanoic acid) 5 g 115.10 -20oC [38315-43-4] Crystalline Purity: 98% Enzyme inhibitor Specific agonist for EP1. C9H10O3 MW 166.2 Ref.: Watson, S. and Abbott, A., Trends Pharmacol. Sci., 12, suppl. 24 (1991). 2-PHENYLMELATONIN 5 mg 56.20 MW 386.5 193704 A melatonin antagonist. 25 mg 224.90 RT C19H20N2O2 MW 308.4 PHE-SER-TRP-GLY-ALA-GLU-GLY- 0.25 mg 37.90 153165 GLN-ARG 0.5 mg 57.80 PHENYLMETHYLSULFONYL 250 mg 11.60 -20-0oC [29705-92-8] 1 mg 89.30 195381 FLUORIDE 1 g 16.90 (Experimental Allergic 0-5oC [329-98-6] 5 g 41.50 Encephalogenic Peptide) (PMSF; Phenylmethanesulfonyl fluoride; 25 g 127.85 This peptide is the active fragment of α-toluenesulfonyl fluoride) 100 g 371.35 myelin basic protein. It causes experimental Crystalline allergic encephalo- Purity: 99% myelitis (an inflammatory demyelinating Protease inhibitor. A relatively safe disease of the CNS) via a cell-mediated substitute for toxic immune response. di-isopropylfluorophosphate. Inhibits Ref: 1. Shapira, R., et al., Science, 78, 736 mammalian acetyl cholinesterase, but not (1971). those from fish sources. 2. Westall, F.C., et al., Nature, 229, 22 Ref.: 1. Fahrney, D.E. and Gold, A.M., J. (1971). Am. Chem. Soc., 85, 997 (1963); 2. Moss, MW 1037.1 D.E. and Fahrney, D.E., Biochem. Pharmacology, 27, 2693 (1978); 3. Turini, PHLEOMYCIN 5 mg 47.70 P., et al., J. Pharmacol. Exp. Ther., 167, 98 198674 [11006-33-0] (1969). 0-5oC From Streptomyces verticillus C7H7FO2S MW 174.2 PHORBOL 1 mg 24.80 4-PHENYL-1-(4-PHENYL- 5 mg 47.55 151849 [17673-25-5] 5 mg 121.80 159995 BUTYL)PIPERIDINE 10 mg 76.85 0oC (4β,9α,12β,13α,20-Pentahydroxy- 10 mg 218.90 RT Maleate Salt 25 mg 166.80 tiglia-1,6-dien-3-one) Purity: 98% White powder Sigma ligand. This is the parent diterpene, and may be Ref.: Glennon, R.A., et al., J. Med. Chem., used as starting material for preparing 34, 3360 (1991). derivatives and as a control compound. MW 409.5 POSSIBLE CARCINOGEN! C20H28O6 MW 364.4 3-PHENYLPROPARGYLAMINE 25 mg 47.05 153785 [30011-36-0] 50 mg 94.00 4-α-PHORBOL 1 mg 25.60 0-5oC Hydrochloride 100 mg 187.95 151851 [26241-63-4] 5 mg 123.05 Dopamine β-hydroxylase inhibitor 0oC (4-α-PHR) 10 mg 204.95 C9H9N • HCl MW 167.6 White powder The C4 epimer of phorbol. 3-PHENYLPROPYL ISOTHIOCYANATE 500 mg 19.85 Useful as negative control since it is neither 193779 [2627-27-2] 1 g 27.55 inflammatory nor tumor-promoting. 0-5oC A synthetic compound which induces 5 g 104.75 POSSIBLE CARCINOGEN! Phase II detoxifying enzymes and inhibits C20H28O6 MW 364.4 chemically induced carcinogenesis. Ref.: Wilkinson, J.T., et al., Carcinogenesis, PHORBOL-12-BUTYRATE 1 mg 126.85 16, 1011-15 (1995). 151852 POSSIBLE CARCINOGEN! 5 mg 538.45 o C10H11NS MW 177.3 0 C C24H34O7 MW 434.5 10 mg 1020.00

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ PHORBOL-13-BUTYRATE 1 mg 43.50 4-α-PHORBOL-12,13-DIDECANOATE 1 mg 86.75 151853 [100929-94-0] 5 mg 125.15 151861 [27536-56-7] 5 mg 374.55 0oC Liquid in ampoule 10 mg 205.55 0oC Standard negative control for 10 mg 656.40 POSSIBLE CARCINOGEN! phorbol-12,13-didecanoate C24H34O7 MW 434.5 POSSIBLE CARCINOGEN! C40H64O8 MW 672.9 PHORBOL-12-DECANOATE 1 mg 45.00 151854 [76423-68-2] 5 mg 178.60 PHORBOL-12,13-DIHEXANOATE 1 mg 154.45 o 158981 [37558-17-1] 0 C Liquid in ampoule 10 mg 321.60 o POSSIBLE CARCINOGEN! -20-0 C Purity: 99% C30H46O7 MW 518.7 POSSIBLE CARCINOGEN! MW 560.8 PHORBOL-13-DECANOATE 1 mg 51.65 151855 [76423-69-3] 5 mg 178.60 PHORBOL 16-HYDROXY 12- 1 mg 120.40 o 156221 PALMITATE 13-ACETATE 5 mg 504.90 0 C Liquid in ampoule 10 mg 321.60 o POSSIBLE CARCINOGEN! 0 C [53202-98-5] C30H46O7 MW 518.7 POSSIBLE CARCINOGEN! C39H64O8 MW 660.9 PHORBOL-12,13-DIACETATE 1 mg 36.05 151856 [24928-15-2] 5 mg 141.00 PHORBOL-20-METHOXYTRITYL 5 mg 35.95 0oC Off-white powder 10 mg 232.55 159651 ETHER 25 mg 84.90 0oC [115905-52-7] 100 mg 284.80 Weak tumor promoter, weakly inflammatory. ∼ POSSIBLE CARCINOGEN! Purity: 96-98% C H O MW 448.5 Intermediate used in the synthesis of 24 32 8 phorbol derivatives. PHORBOL-13,20-DIACETATE 1 mg 91.50 POSSIBLE CARCINOGEN! 151857 [41621-85-6] 5 mg 304.90 C40H44O7 MW 636.8 o 0 C White powder 10 mg 510.30 PHORBOL 12-MONOACETATE 1 mg 50.60 Intermediate for preparing phorbol diesters. 156222 [70470-59-6] 5 mg 384.55 POSSIBLE CARCINOGEN! 0oC POSSIBLE CARCINOGEN! 10 mg 656.50 C24H32O8 MW 448.5 C22H30O7 MW 406.5 4α-PHORBOL-12,13-DIACETATE 1 mg 44.55 PHORBOL 13-MONOACETATE 1 mg 117.55 159647 [56144-62-8] 5 mg 182.10 o 156223 [32752-29-7] 5 mg 298.85 0 C Purity: 99% 0oC Off-white powder. 10 mg 510.00 Useful as a negative control for POSSIBLE CARCINOGEN! phorbol-12,13-diacetate. C22H30O7 MW 406.5 POSSIBLE CARCINOGEN! C24H32O8 MW 448.5 PHORBOL-12-MONOMYRISTATE 1 mg 64.20 151862 [20839-06-9] 5 mg 292.15 PHORBOL-12,13-DIACETATE [20- 50 µCi 241.35 0oC Not inflammatory 10 mg 582.30 26042 3H(N)] 250 µCi 568.80 POSSIBLE CARCINOGEN! o 3 0-5 C ( H-PDA) 1 mCi 1332.80 C34H54O7 MW 574.8 Sp. Act. 10-20 Ci/mmol 370-740 GBq/mmol PHORBOL-13-MONOMYRISTATE 1 mg 168.65 151863 POSSIBLE CARCINOGEN! 5 mg 567.60 Ethanol solution. o Please call for delivery information. 0 C C34H54O7 MW 574.8 10 mg 946.00 MW 448.5 PHORBOL-12 MYRISTATE 13- 50 µCi 241.35 26044 ACETATE [20-3H(N)] 250 µCi 556.65 PHORBOL-12,13-DIBENZOATE 1 mg 45.65 o 3 151858 [25405-85-0] 5 mg 120.75 0-5 C ( H-PMA) 1 mCi 1332.80 0oC Off-white powder 10 mg 200.45 Sp. Act. 15-30 Ci/mmol Moderately inflammatory, weak tumor 0.555-1.11 TBq/mmol promoter. Ethanol solution. POSSIBLE CARCINOGEN! Please call for delivery information. MW 616.8 PHORBOL-12,13-DIBUTYRATE 1 mg 38.10 1 mg 36.10 151859 [37558-16-0] 5 mg 98.50 PHORBOL-12-MYRISTATE-13- o 151864 ACETATE 5 mg 130.50 0 C White powder 10 mg 187.15 o Moderate tumor promoter 0 C [16561-29-8] 10 mg 250.55 POSSIBLE CARCINOGEN! (PMA) 25 mg 625.25 C H O MW 504.6 Very potent tumor promoter 28 40 8 Highly inflammatory 4α-PHORBOL 12,13-DIBUTYRATE 1 mg 72.05 POSSIBLE CARCINOGEN! 158980 [93781-54-5] 5 mg 327.00 C36H56O8 MW 616.8 o -20-0 C Purity: 99% 4α-PHORBOL 12-MYRISTATE 13- 1 mg 108.15 POSSIBLE CARCINOGEN! 158982 ACETATE 5 mg 334.00 C28H40O8 MW 504.6 -20-0oC [63597-44-4] PHORBOL-12,13-DIBUTYRATE [20- 50 µCi 241.35 Purity: 99% 3 POSSIBLE CARCINOGEN! 26043 H(N)] 250 µCi 556.65 o C H O MW 616.8 0-5 C (3H-PDBu) 1 mCi 1332.80 36 56 8 Sp. Act. 15-30 Ci/mmol PHORBOL-12-RETINOATE-13- 1 mg 49.20 0.555-1.11 TBq/mmol 151866 ACETATE 5 mg 144.00 Ethanol solution. 0oC [80188-99-4] 10 mg 286.45 Please call for delivery information. Yellow powder MW 504.6 POSSIBLE CARCINOGEN! C H O MW 688.9 PHORBOL-12,13-DIDECANOATE 1 mg 80.50 42 56 8 151860 [24928-17-4] 5 mg 227.70 1 mg 80.55 o PHORBOL-12-TIGLIATE-13- 0 C Highly inflammatory 10 mg 410.55 151867 DECANOATE 5 mg 181.60 Potent tumor promoter 0oC [59086-92-9] 10 mg 292.95 POSSIBLE CARCINOGEN! POSSIBLE CARCINOGEN! C40H64O8 MW 672.9 C35H52O8 MW 600.8

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ PHORBOL-12,13,20-TRIACETATE 1 mg 42.55 PHOSPHODIESTERASE 0.25 U 207.55 151868 [19891-05-5] 5 mg 123.20 159998 [9040-59-9] 1 U 527.40 0oC White powder 10 mg 204.90 -20oC (3′,5′-cyclic-Nucleotide phosphodiesterase; POSSIBLE CARCINOGEN! Phosphodiesterase 3′,5′-cyclic-nucleotide; C26H34O9 MW 490.5 E.C. 3.1.4.17) α From Bovine Brain D- -PHOSPHATIDYLCHOLINE- 0.5 mg 148.20 Activity: 1-5 units/mg protein. 156226 β γ 1 mg 247.10 o -ACETYL- -O-HEXADECYL Unit Definition: one unit will hydrolyze one 0 C [117985-57-6] 5 mg 827.90 µmole 3′,5′-cAMP to 5′-cAMP per minute (3-o-Hexadecyl-2-o-acetyl-sn-glycero-1-phos at pH 7.5, 30°C. phorylcholine; Enantio-PAF C-16) Synthetic Purity: 98% C26H54NO7P MW 523.7 PHOSPHODIESTERASE I 100 U 108.20 α β 100978 [9025-82-5] L- -PHOSPHATIDYLCHOLINE- - 1 mg 44.75 o 156229 γ 5 mg 179.55 0 C From Crotalus Adamanteus o ACETYL- -O-(OCTADEC-9-cis-ENYL) 0 C [85966-90-1] 10 mg 324.30 Lyophilized in vials containing approximately 5 mg dry wt. and at least 100 (Dehydro-PAF[C18]) Synthetic units/vial (20-40 units/mg dry wt.) Unit Definition: One unit hydrolyzes Purity: 99% µ Yellow semi-solid. 1 mole of p-nitrophenyl thymidine-5-phosphate per minute at pH C28H56NO7P MW 549.7 8.9 and 25°C. L-α-PHOSPHATIDYLCHOLINE-β- 5 mg 98.60 159196 γ 10 mg 177.70 o ACETYL- -O-OCTADECYL -20 C [79549-26-1] 25 mg 355.40 (Platelet Activating Factor C-18; PHOSPHODIESTERASE II 1 vial 125.70 1-O-Octadecyl-2-O-acetyl-sn-glycero-3-phos 100977 [9068-54-6] phocholine) 0oC From Bovine Spleen Purity: 99% Lyophilized in vials from 0.001 M sodium Platelet activating factor pyrophosphate, 10-15 units/vial. C28H58NO7P MW 551.7 Unit Definition: One unit is defined as a change in absorbancy of 0.2 at A260 at L-α-PHOSPHATIDYLCHOLINE-β- 1 mg 51.60 37°C, pH 6.5 with an RNA substrate. 159195 γ 5 mg 235.05 o ARACHIDONOYL- -O-HEXADECYL -20 C [86288-11-1] 10 mg 447.20 (1-O-Hexadecyl-2-O-arachidonoyl-sn-glycero -3-phosphorylcholine) PHOSPHOENOLPYRUVIC ACID 25 mg 11.00 Purity: 98% 195707 [4265-07-0] 100 mg 32.80 Platelet activating factor precursor in the 0oC (2-[Phosphonooxy]-2-propenoic Acid; PEP) 250 mg 66.95 lipid remodeling pathway. Monopotassium Salt 1 g 236.25 Ref.: Chilton, F.H., et al., J. Biol. Chem., C3H4O6PK MW 206.1 259, 12014 (1984). C44H82NO7P MW 768.2

DL-α-PHOSPHATIDYLCHOLINE, 25 mg 19.65 156230 DILAUROYL 100 mg 66.80 PHOSPHOENOLPYRUVIC ACID 25 mg 11.00 o 195708 [53823-68-0] 100 mg 38.75 0 C [18656-40-1] 500 mg 324.00 o (1,2-Didodecanoyl-rac-glycero-3-phosphocho 0 C (2-[Phosphonooxy]-2-propenoic Acid; PEP) 250 mg 80.20 line) Monosodium Salt 1 g 282.75 Purity: 99% Hydrate C3H4O6PNa MW 190.0 C32H64NO8P MW 621.8

PHOSPHATIDYLCHOLINE-L-α- 10 µCi 702.20 16014 DIPALMITOYL, [2-Palmitoyl-1-14C] 50 µCi 1939.20 0-5oC Sp. Act. 40-60 mCi/mmol PHOSPHOENOLPYRUVIC ACID 25 mg 10.35 1.48-2.22 GBq/mmol 151872 [5541-93-5] 100 mg 14.40 Ethanol:toluene (1:1). 0oC Trisodium Salt 250 mg 26.55 Please call for delivery information. Crystalline 500 mg 50.40 MW 734.0 Monohydrate 1 g 89.20 (PEP) 5 g 355.60 L-α-PHOSPHATIDYLCHOLINE-β- 0.1 mg 74.75 PEP is the primary driving force in many 156232 γ 0.5 mg 283.00 o (PYREN-1-YL)HEXANOYL- - kinase reactions. When coupled with 0 C PALMITOYL 1 mg 506.35 pyruvate kinase, it completes an [103625-33-8] ATP-regenerating system. C46H68NO8P MW 794 C3H2O6PNa3 • H2O MW 252 PHOSPHATIDYLETHANOL 10 mg 77.40 158983 (1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoet 25 mg 184.30 -20-0oC hanol) 50 mg 367.40 PHOSPHOLIPASE A2 500 µg 49.85 Purity: 98% 195684 [9001-84-7] 1 mg 73.50 Used as a chromatographic standard to o -20 C (PLA2; Phosphatidylcholine assay PLD activity in intact cells via the 2-Acylhydrolase) conversion of phosphatidylcholine to From Apis mellifera phosphatidylethanol by phospholipase D in EC 3.1.1.4 the presence of ethanol. Lyophilized Ref.: 1. Kobayashi, M. and Kanfer, J.N., J. Activity: 600-1800 units/mg protein Neurochem., 48, 1597 (1987). 2. Unit Definition: one unit will hydrolyze 1 Gustavsson, L. and Alling, C., Biochem. µmol of soybean L-α-phosphatidylcholine Biophys. Res. Commun., 142, 958 (1987). to L-α-lysophosphatidylcholine and fatty 3. Liscovitch, M., J. Biol. Chem., 264, 1450 ° (1989). 4. Pai, J.-K., et al., ibid., 263, 12472 acid per minute at pH 8.9, 25 C. (1988). MW 703

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $

PHOSPHOLIPASE A2 5 mg 196.40 PHOSPHOLIPASE C, 5 U 183.45 151873 [9001-84-7] 25 mg 457.00 159833 PHOSPHATIDYLINOSITOL-SPECIFIC 0-5oC (Lecithinase-A; 0oC (PIPLC) Phosphatide-2-acylhydrolase) Recombinant From: Porcine pancreas From B. subtilis. E.C.3.1.1.4 This phosphatidylinositol-specific Unit Definition: One unit hydrolyzes 1.0 phospholipase C is a recombinant product µmole of L-α-phosphatidyl choline to isolated from B. subtilis transfected with the L-α-lysophosphatidyl choline and a fatty PIPLC gene from B. thuringiensis.It is very acid per minute at a reaction time of 5-10 stable and demonstrates broad specificity, minutes, pH 8.0 at 40°C. making it useful for the detection of Supplied as a pale yellow lyophilized glycosyl-phosphatidylinositol membrane powder. anchors, antibody production, and Specific Activity: Minimum 100 IU/mg. structure-function studies. Our phospholipase A2 is heat stable with an Activity: >500 U/mg protein. isoelectric point of pH 6.3. Unit Definition: One unit will hydrolyze 1 Ref.: Van Deenan, L.L.M.,de Haas, G.H., µmole of phosphatidylinositol per minute at Biochim. Biophys. Acta, 70, 538-553 (1963). pH 7.5 and 37 °C. Ref.: Low, M.G., et al., J. Immunol. Methods, 113, 101 (1988)

PHOSPHOLIPASE A2 ACTIVATING 100 µg 91.70 PHOSPHOLIPASE C, 5 U 236.25 159653 195685 o PEPTIDE PHOSPHATIDYLINOSITOL-SPECIFIC 0 C Glu-Ser-Pro-Leu-Ile-Ala-Lys-Val-Leu-Thr-Thr -20oC [9001-86-9] -Glu-Pro-Pro-Ile-Ile-Thr-Pro-Val-Arg-Arg (PIPLC) This peptide fragment has been shown to From Bacillus cereus activate Phospholipase A2. The amino acid EC 3.1.4.10 sequence shows similarity to melittin. Purity: >95% by SDS-PAGE Ref.: Clark, M.A., et al., Proc. Nat. Acad. Activity: 600 units/mg protein Sci. USA, 88, 5418 (1991). Unit Definition: one unit will liberate 4 units MW 2330.8 of glycosyl-PI-anchored acetylcholinesterase per minute at pH 7.4, 37°C. May be used to release phosphatidylinositol PHOSPHOLIPASE Cγ 100 µg 416.75 (PI)-linked proteins from membranes. 695001 Supplied in 50 mM TEA, ph 7.5, 10 mM o MONOCLONAL ANTIBODY -20 C (PLCγ) EDTA, 10 mM NaN3. Anti-Bovine Clone: PLC 3 10 PHOSPHOLIPASE D 1 KU 29.40 Isotype: purified IgG 195686 [9001-87-0] 10 KU 266.50 Conc/Titer: 1:1,000 -20oC (Phosphatidylcholine Applications: ELISA; Immunoblotting Phosphatidohydrolase) PLCγ hydrolyzes phosphatidyl inositol-4-5 1 From Streptomyces sp. biphosphate and diacylglycerol, the former EC 3.1.4.4 acting as a second messenger in calcium Activity: 24,000 units/mg protein signaling and the latter becoming an Unit Definition: one unit will liberate 1 activator of protein Kinase C. µmol of choline from A synthetic peptide corresoponding to L-α-phosphatidylcholine per hour at pH 5.6, positions 1040-1057 of the bovine brain 37°C. enzyme was used as the immunogen. Also active on other phosphatidyl esters It is supplied at a concentration of 1 mg/ml and sphingomyelins. in 40% glycerol, 20 mM sodium phosphate, pH 7.5, 150 mM NaCl & 3 mM NaN3. Ref: 1. Rhee, S.G., et al., Science 244, 546 PHOSPHOMYCIN 1 g 12.85 151876 [26016-99-9] 5 g 38.90 (1989). o 2. Nishibe, et al., J. Biol. Chem. 264, 10335 0-5 C Disodium Salt 10 g 64.85 (1990). Antibiotic C3H5O4PNa2 MW 182

PHOSPHORAMIDON 0.5 mg 20.85 5 U 237.95 152851 [119942-99-3] 1 mg 33.70 PHOSPHOLIPASE C, o α 152354 PHOSPHATIDYLINOSITOL-SPECIFIC -20-0 C (N-[ -Rhamnopyranosyl- 5 mg 115.90 0oC (PIPLC) oxyhydroxyphosphinyl]-Leu-Trp) From Bacillus thuringiensis. Microbial Source This phosphatidylinositol-specific Sodium Salt phospholipase C is a phospholipid Inhibitor for thermolysin and collagenase. degradation enzyme which cleaves PI into Ref: Suda, H., et al., J. Antibiot., 26, 621 diglyceride and (1963). myo-inositol-cyclic-1,2-phosphate. PIPLC C23H34N3O10PNa2 MW 588.5 does not act on phosphatidylcholine, phosphatidylethanolamine, PHOSPHORYLASE KINASE 250 U 26.25 phosphatidylglycerol, or sphingomyellin. 195998 [9001-88-1] 1 KU 98.40 PIPLC has an optimum pH range of -20oC (Dephosphophosphorylase Kinase; 7.0-8.5, and performs well at temperatures ATP:phosphorylase b Phosphotransferase) of 30°C to 50°C. EC 2.7.1.38 Unit Definition: One unit cleaves 1.0 From Rabbit Muscle µmole of phosphatidylinositol per minute Lyophilized into myo-inositol phosphate ester Activity: ∼200-500 units/mg protein (determined after conversion to inorganic Unit Definition: one unit will form 1 µmol phosphate) at pH 7.5 and 37°C. of phosphorylase-a from phosphorylase-b per minute at pH 7.7, 30°C in the presence of ATP.

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ PHOSPHOTYROSINE 100 µg 280.70 PILOCARPINE 1 g 17.75 691371 MONOCLONAL ANTIBODY 151892 [54-71-7] 5 g 61.60 0-5oC Clone: PY20 RT Hydrochloride 10 g 101.90 Isotype: mouse IgG2b Crystalline Conc/Titer: 1 mg/ml Parasympathomimetic Applications: Immunoblotting; ELISA; C11H16N2O2 • HCl MW 244.7 Immunohistology; Immunoprecipitation PILOCARPINE 1 g 16.70 PHOSPHOTYROSINE 100 µg 412.75 151893 [148-72-1] 5 g 55.70 691381 MONOCLONAL ANTIBODY RT Nitrate 10 g 90.60 0-5oC Clone: PY69 Crystalline • Isotype: mouse IgG2a C11H16N2O2 HNO3 MW 271.3 Conc/Titer: 1 mg/ml Applications: Immunoblotting; ELISA; PIMOZIDE 25 mg 14.45 Immunohistology; Immunoprecipitation 153787 [2062-78-4] 50 mg 23.95 RT (1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidin 100 mg 43.35 PHOSPHOTYROSINE 100 µg 366.60 yl]-1,3-dihydro-2H- 691501 MONOCLONAL ANTIBODY benzimidazol-2-one) -20oC Anti-Phosphotyrosine Calcium channel antagonist Clone: PY20 C28H29F2N3O MW 461.6 Isotype: mouse IgG2b Applications: Immunoassay. PINACIDIL 5 mg 13.75 Biotinylated 159808 [85371-64-8] 25 mg 43.50 This antibody is the same as ICN Code No. RT Antihypertensive and potassium channel 100 mg 160.55 69-137-1 that has been conjugated with activator. biotin. C13H19N5 MW 245.3 Conc/Titer: 1:6,000 PINDOLOL 250 mg 14.35 151895 [13523-86-9] 1 g 33.40 PHOSPHOTYROSINE 50 µg 325.50 o 691531 MONOCLONAL ANTIBODY 0-5 C (1-[1H-indol-4-yloxyl]-3-[isopropyl-amino]-2-p 5 g 103.40 o ropanol) -20 C Anti-Phosphotyrosine β Clone: PY20 A -adrenergic compound. C14H20N2O2 MW 248.3 Isotype: mouse IgG2b Applications: Immunoassay. 10-[3-(1-PIPERAZINYL)PROPYL]-2- 5 mg 52.75 FITC Conjugated 159652 TRIFLUOROMETHYLPHENOTHIAZINE 10 mg 97.80 This antibody is the same as ICN Code No. 0oC 25 mg 197.60 that has been conjugated with fluorescein DIMALEATE isothiocyanate. Potent inhibitor of protein kinase C. Conc/Titer: 1:1,000 Ref.: Aftab, et al., Mol. Pharm., 40, 798 (1991) PHOSPHOTYROSINE 100 µg 363.10 C28H26F3N3O4S MW 557.6 691511 MONOCLONAL ANTIBODY ± -20oC ( )-cis-2,3-PIPERIDINE- 15 mg 21.75 Anti-Phosphotyrosine 153792 25 mg 32.55 Clone: PY20 DICARBOXYLIC ACID RT [82949-15-3] 50 mg 57.80 Isotype: mouse IgGb Applications: Immunoassay. NMDA agonist HRP Conjugated C7H11NO4 MW 173.2 This antibody is the same as ICN Code No. PIRENPERONE 25 mg 37.95 69-137-1 that has been conjugated with 153790 [75444-65-4] 50 mg 69.65 horseradish peroxidase. RT (3-[2-[4-(4-Fluorobenzoyl)-1- 100 mg 126.80 Conc/Titer: 1:1,000 piperidinyl]-ethyl-2-methyl-4H- PHYTOLACCA AMERICANA 1 mg 53.35 pyrido[1,2-a]pyrimidin-4-one) 153327 AGGLUTININ 5 mg 208.25 5-HT2 serotonin antagonist 0-5oC [63231-57-2] C23H24FN3O2 MW 393.5 (Pokeweed Mitogen) PIRENZEPINE 100 mg 19.10 Purified by affinity chromatography 153789 [28797-61-7] 150 mg 27.35 Salt and sugar free. µ RT (5,11-Dihydro-11-[(4-methyl-1-piperazinyl)-ac 250 mg 43.35 Activity: <20 g/ml etyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on 10 µg agglutinates fresh human 2% type O e) erythrocytes in 0.01M PBS, pH 7.45. Dihydrochloride Exhibits specificity for (D-glcNAc)3 and M1 muscarinic antagonist and demonstrates mitogenic properties at anticholinergic µ approximately 2.5 g per ml. C19H21N5O2 • 2HCl MW 424.3 PICOTAMIDE 10 mg 108.95 PIROXICAM 1 g 17.45 159197 [32828-81-2] 25 mg 258.00 156277 [36322-90-4] 5 g 65.90 RT Purity: 98% 50 mg 470.10 0-5oC (4-Hydroxy-2-methyl-3[pyrid-2-yl-carbamoyl]- 10 g 117.95 TxA2 synthase inhibitor and thromboxane 2H-1,2-benzothiazine 1,1-dioxide) A2 antagonist. Cyclooxygenase inhibitor Ref.: 1. Modesti, P.A., et al., Eur. J. C15H13N3O4S MW 331.3 Pharmacol., 169, 85 (1989). 2. Berrettini, M., et al., Eur. J. Clin. Pharmacol., 39, 495 PLATELET ACTIVATING FACTOR C-16 (1990). 3. Numano, F., et al., Thromb. Haem., 62, 554 (1989). See: L-α-Phosphatidylcholine-β-Acetyl-γ-O-Hexadecyl MW 376.2 PLATELET ACTIVATING FACTOR C-18 PICROTOXIN 1 g 36.50 151889 [124-87-8] 2 g 69.20 See: L-α-Phosphatidylcholine-β-Acetyl-γ-O-Octadecyl 0oC (Cocculin) Purity: >98% PODOPHYLLOTOXIN 100 mg 27.55 A GABA-receptor antagonist. 154253 [518-28-5] 500 mg 115.60 Ref.: Soubrie, P., et al., Pharmacol. 0-5oC A potent inhibitor of microtubule assembly. Biochem., 10, 463 (1979). Purity: ≥98% C30H34O13 MW 602.6 C22H22O8 MW 414.4

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ POLY(ADP-RIBOSE) POLYMERASE 100 µg 367.50 PROGLUMIDE 100 mg 97.60 196026 (PARP) 151950 (4-Benzoylamino-5-dipropylamino-5-oxopent 500 mg 272.35 -70oC From Bovine RT anoic acid sodium salt) Can be used as a substrate for CPP32 Sodium Salt (Apopain) or other proteases such as Selective cholecystokinin antagonist, water Granzyme B. Can be automodified with soluble, gastrin receptor antagonist. NAD and used as a western blot standard and to synthesize poly(ADP-Ribose) polymer in ELISA assays for autoimmune PROPOFOL 1 g 13.25 disease, polymer binding proteins and 193707 [2078-54-8] 5 g 39.70 glycohydrolase assays. RT (2,6-Diisopropylphenol) Supplied in solution as 1 mg/ml in 50 mM A short acting general anesthetic which Tris, pH 8.0. exhibits direct activation of the GABAA MW 116 KDA receptor and inhibition of glutamate receptor-mediated synaptic transmission. POLYMYXIN B SULFATE 1 MU 9.85 Ref.: Orser, et al., Br. J. Pharmacol., 116, 100565 [1405-20-5] 5 MU 23.25 1761 (1995). 0-5oC Aerosporin 10 MU 40.70 C12H18O MW 178.3 Activity: >6,000 u/mg 25 MU 79.50 50 MU 142.00 DL-PROPRANOLOL 1 g 8.90 190088 [3506-09-0] 5 g 26.90 POLYMYXIN B SULFATE 1 MU 11.55 (1-[Isopropylamino]-3- 25 g 101.65 194538 [1405-20-5] 5 MU 27.55 o [1-naphthyloxy]-2-propanol) 100 g 270.00 0-5 C Cell Culture Reagent Purity: 98% Aerosporin Hydrochloride Activity: >6,000 u/mg Crystalline A β-adrenergic blocker. Inhibitor of POTASSIUM PENTA- 5 mg 40.80 phosphatidate phosphohydrolase blocking 193706 CHLORONITROSYLRUTHENIUM 25 mg 163.15 PLD derived DAG formation. 0-5oC A caged nitrosyl compound that releases Ref.: 1. Billah, M.M., et al., J. Biol. Chem., NO in 1msec by laser flash photolysis (320 264, 17069 (1989). 2. Billah, M.C., et al., nm). FEBS Lett, 233, 153 (1988). 3. Barret, et K2Ru(NO)Cl5 MW 386.5 al., Brit. J. Pharmacol., 34, 43 (1968). C16H21NO2 • HCl MW 295.8 PRAZOBIND 10 mg 204.70 153781 (1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4- 15 mg 296.40 0-5oC (2-bicyclo[2,2,2]octa-2,5-dienylcarbonyl)piper 25 mg 454.60 (R)-(+)-PROPRANOLOL 100 mg 46.80 156412 [13071-11-9] 500 mg 208.45 azine) o C23H27N5O3 MW 421.0 0-5 C Hydrochloride C16H21NO2 • HCl MW 295.8 PRAZOSIN 25 mg 26.10 153782 [19237-84-4] 50 mg 47.70 (S)-(-)-PROPRANOLOL 100 mg 60.40 RT (1-(3-Amino-6,7-dimethoxy-2- 100 mg 86.75 156413 [4199-10-4] 500 mg 257.25 quinazolinyl)-4-(2-furanyl-carbonyl)piperazine RT Hydrochloride hydrochloride) 5-HT antagonist and β adrenergic blocker Hydrochloride 1 C16H21NO2 • HCl MW 295.8 α1 adrenergic antagonist C19H21N5O4 • HCl MW 419.9 PROPYL β-CARBOLINE-3-CARBOXYLATE 5-PREGNEN-3β-OL-20-ONE-16α- 50 mg 27.60 156362 CARBONITRILE 100 mg 50.25 See: β-Carboline-3-carboxylic acid propyl ester 0-5oC [1434-54-4] 250 mg 114.60 (Pregnenolone-16α-carbonitrile) Purity: R(-)-PROPYLNORAPOMORPHINE 2 mg 18.05 Activates the transcription of the PCN1 153773 [18426-20-5] 5 mg 36.15 gene and induces cytochrome P-450 0-5oC (R(-)-10,11-Dihydroxy-N-n-propylnoraporphin 10 mg 72.25 activity. e hydrochloride) Ref.: 1. Hardwick, J.P., et. al., J. Biol. Hydrochloride Chem., 258, 10182 (1983). 2. Watkins, D2 Dopamine receptor agonist P.B., et. al., Proc. Natl. Acad. Sci. USA, 82, C19H21NO2 • HCl MW 331.8 6310 (1985). 3. Gonzalez, F.J., et. al., Mol. Cell. Biol., 6, 2969 (1986). C22H31NO2 MW 341.5 S(+)-PROPYLNORAPOMORPHINE 2 mg 115.70 153777 (S(+)-NPA) 5 mg 258.35 o PRO-ASP-VAL-ASP-HIS-VAL-PHE- 1 mg 68.50 0-5 C (+)-10,11-Dihydroxy-N-n-propylnoraporphine 157923 LEU-ARG-PHE-AMIDE 5 mg 312.55 ) o Hydrochloride 0 C [121801-61-4] • From Locust C19H21NO2 HCl MW 331.8 (Schistocera gregaria) FMRF-amide like neuropeptide. 3-n-PROPYLXANTHINE 25 mg 19.85 Purity: 97% 153779 [41078-02-8] 50 mg 38.70 MW 1243.4 0-5oC (Enprofylline) 100 mg 74.75 Weak A1 and A2 adenosine receptor PROCTOLIN 1 mg 30.30 antagonist 151949 [57966-42-4] 5 mg 93.30 C8H10N4O2 MW 194.2 -20-0oC (Arg-Tyr-Leu-Pro-Thr) 10 mg 166.40 An insect neurotransmitter. 25 mg 362.15 Ref.: 1. Starratt, A.N. and Brown, B.E., Life 9-n-PROPYLXANTHINE 25 mg 26.10 Sci., 17,1253 (1976). 153776 [125833-04-7] 50 mg 47.70 o 2. O’Shea, M., et al., Science, 213, 567 0-5 C C8H10N4O2 MW 194.2 100 mg 86.75 (1981).

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ 20S PROTEASOME 500 µg 108.95 PROTEIN KINASE p34cdc2 1 mg 412.75 193625 Recombinant 159654 SUBSTRATE 0oC Expressed in E. coli 0-5oC Ala-Asp-Ala-Gln-His-Ala-Thr- A threonine protease with two distinct Pro-Pro-Lys-Lys-Lys-Arg-Lys- endopeptidase activities hydrolyzing Val-Glu-Asp-Pro-Lys-Asp-Phe proteins on the carboxyl side of Synthetic substrate used in studies of hydrophobic and acidic amino acid residues Protein Kinase p34cdc2. Shows no activity as (chymotrypsin-like and a substrate for protein kinase C. peptidylglutamyl-peptide hydrolase Ref.: Marshak, D.R., et al., J. Cell. activities). Biochem., 45, 391 (1991). Activity: chymotrypsin-like activity: MW 2407.0 hydrolysis of Suc-Ala-Ala-Phe-AMC yields 1.2 nmol of 7-amino-4-methylcoumarin PROTOPINE 5 mg 14.70 159809 [6164-47-2] 25 mg 29.40 (AMC) per minute per mg protein. o Petidylglutamyl-peptide hydrolase activity: 0-5 C Hydrochloride 50 mg 42.00 hydrolysis of CBZ-Leu-Leu-Glu-β-NA yields Inhibits the release of arachidonic acid and 100 mg 63.00 8.9 nmol of β-naphthylamine per minute Platelet Activation Factor from membrane 500 mg 236.25 phospholipids. per mg protein. • Unit Definition: one unit is the amount of C20H19NO5 HCl MW 389.8 enzyme that hydrolyzes one nmol of PROTOPORPHYRIN IX 250 mg 14.55 peptide in one minute at 60°C. 102757 [50865-01-5] 1 g 39.65 Ref.: Maupin-Furlow, J.A. and Ferry, J.G., 0-5oC Disodium Salt 5 g 159.80 J. Biol. Chem., 270, 28,617-28,622 (1995). Purity: ∼95% C H N O Na MW 606.6 20S PROTEASOME α-SUBUNIT 500 µg 108.95 34 32 4 4 2 193626 Recombinant PROTOPORPHYRIN IX DIMETHYL 25 mg 16.85 0oC From Methanosarcina thermophila 156424 ESTER 100 mg 45.50 Expressed in E. coli 0-5oC [5522-66-7] 500 mg 218.10 MW ∼24 kDa From Ox Hemin α µ Purity: 95% 20S PROTEASOME -SUBUNIT 100 l 86.00 Crystalline 697501 POLYCLONAL ANTIBODY 1% 3 0oC Purity based on E407 = 2.89 X 10 in CHCl3 Anti-Human C H N O MW 590.7 Host: rabbit 36 38 4 4 Form: liquid whole antisera PTIO 10 mg 27.50 Conc/Titer: 1:20,000 159830 (2-Phenyl-4,4,5,5-tetra- 25 mg 37.70 Applications: Western Blotting, -20oC methylimidazoline-1-oxyl-3-oxide) 100 mg 146.00 Immunodetection Purity: ≥ 96% This antibody is specific for the 20S A stable nitric oxide (NO) scavenger. proteasome α-subunit. It does not Ref.: Maeda, H., et al., Jpn. J. Cancer cross-react with the β-subunit. Res., 85, 331 (1994). Also see Carboxy-PTIO. β µ 108.95 20S PROTEASOME -SUBUNIT 500 g C13H17N2O2 MW 233.3 193627 Recombinant 0oC From Methanosarcina thermophila PUROMYCIN 10 mg 13.55 100552 [58-58-2] 25 mg 29.15 Expressed in E. coli o MW ∼22 kDa 0 C Dihydrochloride 100 mg 103.65 Crystalline 250 mg 225.90 PROTEIN G ANTAGONIST 2 1 mg 137.60 Antimicrobial 500 mg 413.85 158346 Pyr-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2 o Causes premature chain termination in 1 g 760.35 -20 C Purity: 99% protein synthesis, and is an inhibitor of Reversible and competitive inhibitor of G aminopeptidase and enkephalinase. proteins. Ref.: 1. Reboud, A.M., et al., Biochemistry, Ref.: Mukai, H., et al., J. Biol. Chem., 267, 20, 5281 (1981); 2. Pekarek, J., et al., 16237 (1992). Immunology, 31, 773 (1976). MW 1093.6 C22H29N7O5 • 2HCl MW 544.4 PROTEIN G ANTAGONIST 2A 1 mg 131.90 PUROMYCIN 10 mg 15.95 158348 Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-T 194539 [58-58-2] 25 mg 31.95 o o -20 C rp-Met-NH2 0 C Cell Culture Reagent 100 mg 121.25 Purity: 99% Dihydrochloride Reversible and competitive inhibitor of G Crystalline proteins. Antimicrobial Ref.: Mukai, H., et al., J. Biol. Chem., 267, Causes premature chain termination in 16237 (1992). protein synthesis, and is an inhibitor of MW 1589.3 aminopeptidase and enkephalinase. 100 µg 71.10 Ref.: 1. Reboud, A.M., et al., Biochemistry, PROTEIN KINASE C ACTIVATING 20, 5281 (1981); 2. Pekarek, J., et al., 159656 PEPTIDE 1 mg 418.55 o Immunology, 31, 773 (1976). 0-5 C Fragment 530-558 C H N O • 2HCl MW 544.4 Leu-Leu-Tyr-Glu-Met-Leu-Ala-Gly-Gln-Ala-Pr 22 29 7 5 o-Phe-Glu-Gly-Glu-Asp-Glu-Asp-Glu-Leu-Ph PUTRESCINE 1 g 5.00 e-Gln-Ser-Ile-Met-Glu-His-Asn-Val 100441 [110-60-1] 5 g 7.10 Activates Protein Kinase C. RT (1,4-Diaminobutane) 25 g 24.45 MW 3355.07 Free Base 100 g 71.20 Purity: ∼98% PROTEIN KINASE C 1 mg 166.25 C H N MW 88.15 159655 4 12 2 PSEUDOSUBSTRATE 14 0-5oC (Protein Kinase C (19-31)) PUTRESCINE [1,4- C] 50 µCi 204.95 16015 Dihydrochloride 250 µCi 605.15 Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gly-Ly o s-Asn-Val 0-5 C Sp. Act. 100-120 mCi/mmol 1 mCi 1696.65 MW 1542.8 3.70-4.44 GBq/mmol 0.01N HCl solution. PROTEIN KINASE C SUBSTRATE 1 mg 44.65 Please call for delivery information. 159658 Lys-Arg-Thr-Leu-Arg-Arg 5 mg 178.85 • o NH2CH2(CH2)2CH2NH2 HCl 0-5 C MW 829.1 MW 161.1 One call. One source. 1215 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ PUTRESCINE [2,3-14C] 50 µCi 314.10 QUERCETIN 10 g 10.10 16016 Dihydrochloride 250 µCi 677.95 152003 [6151-25-3] 25 g 20.25 0-5oC Sp. Act. 100-120 mCi/mmol 1 mCi 1817.90 RT (3,3′,4′,5,7-Pentahydroxyflavone) 100 g 62.75 3.70-4.44 GBq/mmol Dihydrate 0.01N HCl solution. Crystalline Please call for delivery information. Inhibitor of protein tyrosine kinases. NH2CH2(CH2)2CH2NH2 • HCl C15H10O7 • 2H2O MW 338.3 MW 161.1 3 QUIN 2 10 mg 112.15 PUTRESCINE [2,3- H(N)] 1 mCi 386.85 190090 [73630-23-6] 50 mg 376.75 26047 Dihydrochloride 5 mCi 1029.65 o o 0 C (2-[(2-bis-[Carboxymethyl]amino-5- 0-5 C Sp. Act. 60-120 Ci/mmol methylphenoxy)methyl]-6- 2.22-4.44 TBq/mmol methoxy-8-bis[carboxymethyl] 0.01N HCl solution. aminoquinoline) Please call for delivery information. • Fluorescent probe for calcium. NH2CH2(CH2)2CH2NH2 HCl Calcium specific chelator and indicator that MW 161.1 causes a shift in UV spectrum upon binding PUTRESCINE 1 g 5.30 to calcium, and enhances fluorescence. 100450 [333-93-7] 5 g 8.15 Ref.: Tsien, R.Y., et al., J. Cell Biol., 94, 325 RT (Diaminobutane dihydrochloride) 25 g 36.85 (1982). Dihydrochloride 100 g 120.50 C26H27N3O10 MW 541.5 Crystalline Purity: ∼98% QUIN 2-AM 5 mg 69.20 C4H12N2 • 2HCl MW 161.1 190051 [83104-85-2] 10 mg 123.95 RT (2-[(2-bis-[Carboxymethyl]amino-5- 25 mg 281.65 PYRENYLMETHYL OKADAATE 10 µg 77.50 methylphenoxy)methyl]-6-methoxy- 50 mg 538.75 158985 Purity: ≥98% (HPLC) 25 µg 155.30 o 8-bis-[carboxymethyl]amino- -20-0 C A fluorescent derivative of okadaic acid 50 µg 279.05 quinolinetetrakis[acetoxymethyl]ester) used as a standard in okadaic acid analysis. 100 µg 502.90 Useful as a fluorescent calcium ion buffer C61H78O13 MW 1019.3 and indicator. PYRIDOSTIGMINE BROMIDE 1 g 19.70 Ref.: Tsien, R.Y., et al., J. Cell Biol., 94, 325 193422 [101-26-8] 5 g 66.15 (1982). RT (3-Dimethylaminocarbonyloxy-N-methylpyrid 25 g 220.70 C38H43N3O18 MW 829.8 inium bromide) C H BrN O MW 261.1 QUINACRINE 25 g 27.75 9 13 2 2 152004 [69-05-6] 100 g 77.00 N,N,N′′′,N′′′,-tetrakis(2-PYRIDYL- 50 mg 55.90 RT Dihydrochloride 156458 METHYL)ETHYLENEDIAMINE 100 mg 100.40 Crystalline RT [16858-02-9] 500 mg 397.95 Dihydrate (TPEN) Fluorescent probe with Purity: 98% acetylcholine-activated synaptic Intracellular Zn2+ chelator with low affinity membranes. Also a monoamine oxidase for Mg2+and Ca2+. Used with QUIN 2 to inhibitor. 2+ measure free Ca in cells. C23H30ClN3O • 2HCl • H2O MW 490.9 C26H28N6 MW 424.5 QUINIDINE [9-3H] 250 µCi 702.20 PYRILAMINE MALEATE 5 g 8.45 26048 Sp. Act. 10-20 Ci/mmol 1 mCi 1454.10 190043 [59-33-6] 25 g 27.25 0-5oC 370-740 GBq RT (Mepyramine maleate) 100 g 74.75 Ethanol solution Crystalline Shipped in Dry Ice. H1 Histamine antagonist Please call for delivery information. • C17H23N3O C4H4O4 MW 401.5 MW 324.4 L-trans-PYRROLIDINE-2,4- 5 mg 72.75 158544 DICARBOXYLIC ACID 10 mg 120.00 QUINIDINE SULFATE 10 g 30.05 RT [64769-66-0] 25 mg 284.00 102791 [6591-63-5] 25 g 66.30 Purity: 98% RT Crystalline 50 g 125.05 A sodium channel blocker. Selectively and potently inhibits the uptake • of glutamate. (C20H24N2O2)2 H2SO4 MW 746.9 Ref.: 1. Bridges, R.J., et al., J. Med. Chem., 34, 717 (1991). QUININE 10 g 14.30 2. Balcar, V.J., et al., FEBS Lett., 300, 203 102792 [6119-70-6] 25 g 31.55 (1992). RT Hemisulfate 50 g 45.65 MW 159.1 Crystalline 100 g 82.70 Purity: 90-95% PYRROLIDINEDITHIOCARBAMATE 25 g 25.30 A potassium channel blocker. 156470 [5108-96-3] 100 g 91.55 C20H24N2O2 • 1/2H2SO4 MW 373.5 0-5oC (APDC; APDTC: Ammonium pyrrolidinedithiocarbamate) L-QUINUCLIDINYL BENZILATE, 250 µCi 605.15 Ammonium Salt 26045 [Benzylic-4,4′′′-3H(N)] 1 mCi 1393.45 Purity: 99% 0-5oC (QNB) Crystalline Sp. Act. 30-60 Ci/mmol C5H9NS2 • NH3 MW 164.3 1.11-2.22 TBq Ethanol solution -Q- Shipped with Dry Ice. Please call for delivery information. QUAZINONE 10 mg 64.70 MW 337.4 158986 [70018-51-8] 25 mg 156.75 RT (Ro 136438) 50 mg 303.50 ± 1 mg 31.30 Purity: 98% RS( )-QUINUCLIDINYL BENZILATE 153697 [6581-06-2] 5 mg 73.35 Potent inhibitor of cGMP-inhibited o 0-5 C ((±)-QNB; (±)-Quinuclidinyl- 10 mg 132.45 phosphodiesterase. α Ref.: Holck, M., et al., J. Cardiovasc. (RS)- -hydroxydiphenylacetate) Pharmacol., 6, 520 (1984). A muscarinic antagonist. C21H23NO3 MW 337.4 C11H10N3OCl MW 235.7 To place an order: (800) 854-0530, fax (800) 334-6999 1216 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ QUIPAZINE 50 mg 91.70 RESEVERATROL 5 mg 10.50 158987 [4774-24-7] 100 mg 174.85 196052 [501-36-0] 25 mg 24.15 0oC Dimaleate Salt 250 mg 418.55 -20oC (trans-3,4′,5-Trihydroxystilbene) 100 mg 74.80 Purity: 98% Purity: ≥98% 5-HT3 agonist. Present in wine and grapes and found to Ref.: Glennon, R.A., et al., J. Med. Chem., reduce serum lipids, inhibit platelet 29, 2375 (1986). aggregation and act as a C13H15N3 • 2C4H4O4 MW 445.4 chemopreventative agent and antioxidant. Ref.: Jang, M., et al., Science, 275(5297), QUISQUALAMINE 1 mg 30.95 218-220 (1997). 159791 [68373-11-5] 5 mg 123.80 C14H12O3 MW 228.2 RT Exhibits activity at GABAA receptors. C4H7N3O3 MW 145.1 RESINIFERATOXIN 100 µg 55.50 156505 [57444-62-9] 1 mg 128.00 (+)-QUISQUALIC ACID 2 mg 101.25 -20oC From Euphorbia poisonii 153771 [52809-07-1] 5 mg 202.45 o Purity: 95% 0-5 C Synthetic Diterpene ester related to phorbol1 but A glutamate agonist. apparently not tumorigenic.2 C5H7N3O5 MW 189.1 Ref.: 1. Sorg, B., et al., J. Nat. Prod., 45, 347 (1982). QX-314 500 mg 203.95 2. Hergenhahn, M., et al., J. Cancer Res. 193948 A quarternary lidocaine derivative which 1 g 358.30 o Clin. Oncol., 108, 98 (1984). -20 C acts as a local anesthetic. It is a strong C37H40O9 MW 628.7 inhibitor of intracellular voltage-sensitive sodium ion conductance. RESINIFERONOL 9,13,14- 1 mg 87.00 Ref.: Conners, et al., J. Pharmacol. Exp. 159661 ORTHOPHENYLACETATE 5 mg 400.00 Ther., 220, 476 (1982). 0-5oC [57852-42-3] MW 343.3 (ROPA) Purity: 98% -R- Binds to Protein Kinase C, but is not active as a Capsaicin analog. Useful for R 11302 synthesizing Resiniferatoxin analogs. C H O MW 464.6 See: Haloperidol Metabolite III 28 32 6 RESMETHRIN 10 mg 42.00 R 59022 158990 [10453-86-8] 25 mg 98.00 -20-0oC Mixture of isomers 50 mg 176.00 See: Diacylglycerol Kinase Inhibitor I A class Type I pyrethrin that is weakly active and acts as a "negative" control for R 59949 the inhibition of calcineurin (protein See: Diacylglycerol Kinase Inhibitor II phosphatase 2B) by Type II pyrethrins. C22H26O3 MW 391.3 RANITIDINE 1 g 65.10 RIFAMPIN 100 mg 5.80 153563 [66357-35-5] 5 g 130.15 195490 [13294-46-1] 250 mg 11.40 RT (N-[2-[[[5-[(Dimethylamino)methyl]- 0oC (Rifampicin) 1 g 31.80 2-furanyl]methyl]thio]-ethyl]-N′- A rifamycin which specifically inhibits 5 g 122.90 methyl-2-nitro-1,1-ethenediamine) DNA-dependent bacterial RNA Polymerase. 25 g 493.60 Hydrochloride Mammalian RNA polymerase is not H2 Histamine receptor antagonist affected. C13H22N4O3S • HCl MW 350.9 Ref.: Wehrli, et al., Proc. Natl. Acad. Sci., µ 61, 667 (1968). RAPAMYCIN 100 g 55.60 C H N O MW 823 159346 [53123-88-9] 1 mg 171.20 43 58 4 12 -20-0oC Purity: >98% by TLC RILMENIDINE 5 mg 62.85 Yellowish solid 193712 Hemifumarate 25 mg 251.35 Soluble in DMSO. Has been shown to RT An I1-imidazoline binding site ligand and selectively block signaling, leading to the α2-adrenoceptor agonist. Exhibits higher I1 activation of P70 S6 kinase. vs. α2 selectivity than clonidine. Ref.: Terada, N., et.al., J. Biol. Chem., 268, C10H16N2O • 1/2C4H4O4 MW 238.3 12062 (1993). Price, D.J., et.al., Science, 257, 973 (1992). RILUZOLE 10 mg 24.25 C51H79NO13 MW 914.2 193713 [1744-22-5] 50 mg 97.00 RT (2-Amino-6-trifluoro- RAUWOLSCINE 25 mg 21.75 methoxybenzothiazole) 153772 [6211-32-1] 50 mg 36.15 A glutamate release inhibitor which also RT ((α-Yohimbine; 17α-Hydroxy-20α- 100 mg 65.10 blocks voltage-dependent Na+ channels yohimban-16β-carboxylic acid methyl ester) and inhibits GABA uptake. Hydrochloride Ref.: Mantz, et al., Eur. J. Pharmacol., 257, An α2-adrenergic antagonist. R7 (1994). C21H26N2O3 • HCl MW 390.9 C8H5N2OSF3 MW 234.2 REACTIVE BLUE 2 25 g 17.50 RISPERIDONE 5 mg 77.15 152015 [12236-82-7] 100 g 47.70 193714 [106266-06-2] 10 mg 138.90 RT (Procion Blue HB) 500 g 181.00 RT Both a D2 dopamine and 5-HT2 serotonin C.I. 61211 receptor antagonist. Dye Content: Approx. 60% C23H27N4O2F MW 410.5 An inhibitor of ATP-activated channels. C29H17ClN7O11S3Na3 MW 840.1 RITANSERIN 25 mg 85.30 153769 [87051-43-2] 50 mg 120.15 REMOXIPRIDE 5 mg 62.85 RT (6-[2-[4-[bis(4-Fluorophenyl)- 100 mg 227.65 193711 [73220-03-8] 25 mg 251.35 methylene]-1-piperidinyl]-ethyl]- RT Hydrochloride 5H-thiazolo[3,2-a]pyrimidin-5-one) A dopamine D2 receptor antagonist. 5-HT2/5-HT1C serotonin antagonist C16H23N2O3Br • HCl MW 407.8 C27H25F2N3OS MW 477.6

One call. One source. 1217 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ Ro 13-5057 SEMICARBAZIDE 100 g 10.90 102864 [563-41-7] 500 g 50.00 See: Aniracetam RT (Aminourea hydrochloride) Hydrochloride Ro 16-6491 Crystalline, 99% Urease substrate and MAO inhibitor See: N-(2-Aminoethyl)-4-chlorobenzamide CH5N3O • HCl MW 111.5

ROLIPRAM 1 mg 18.25 L-SEPIAPTERIN 1 mg 29.80 159810 [61413-54-5] 5 mg 40.50 o 159813 [17094-01-8] 5 mg 119.20 0-5 C (4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-p 10 mg 62.30 -20oC Sepiapterin is converted intracellularly into yrrolidinone) tetrahydrobiopterin, which causes Purity: ≥98% stimulation of NO production. cAMP-specific phosphodiesterase inhibitor, Ref.: Gross, S.S. and Levi, R.J., J. Biol. selective for phosphodiesterase IV. Chem., 267, 25722 (1992). Ref.: Imanishi, T., et al., Eur. Jour. of C9H11N5O3 • 2H2O MW 273.2 Pharmacol., 321(3), 273-278 (1997). C16H21NO3 MW 275.4 SEROTONIN ROSMARINIC ACID 5 mg 20.65 See: 5-Hydroxytryptamine 159792 C18H16O8 MW 360.3 10 mg 35.80 RT 50 mg 143.30 SEROTONIN ELISA KIT 1 each 558.40 193598 This Serotonin ELISA kit provides materials RUTHENIUM RED 250 mg 32.75 0-5oC for the quantitative determination of 156565 [11103-72-3] 1 g 130.00 chemically derived serotonin in serum, RT (Ruthenium oxychloride ammoniated) 5 g 648.00 plasma, urine, tissue homogenates, and Tetrahydrate cell culture supernatants. The assay Dye Content: Approx. 20% procedure follows the basic principle of A Ca2+ antagonist competitive ELISA whereby there is Ru3Cl6H42N14O2 • 4H2O MW 858.4 competition between a biotinylated and non-biotinylated antigen for a fixed number RYANODINE 5 mg 29.10 of antibody binding sites. The kit is a 12 x 8 195710 [15662-33-6] 25 mg 144.00 format. RT (Ryanadol;3-(1H-pyrrole-2-carboxylate) From Ryania speciosa vahl FOR RESEARCH USE ONLY! A mixture of ryanodine and 9,21-dehydroryanodine (1:1). SIN-1 5 mg 32.05 C25H35NO9 MW 493.5 159831 [16142-27-1] 10 mg 57.35 -20oC (3-Morpholinosydnonimine) 25 mg 114.65 RYANODINE 1 mg 63.50 Hydrochloride 153770 [15662-33-6] 2 mg 114.40 Purity: ≥98% RT (Ryanadol;3-(1H-pyrrole-2-carboxylate) 5 mg 270.90 A nitric oxide (NO) donor. SIN-1 is a From Ryania speciosa vahl metabolite of molsidomine and Inhibits calcium release from the spontaneously decomposes to nitric oxide sarcoplasmic reticulum. and superoxide anion radicals. C25H35NO9 MW 493.5 Ref.: 1. Hess, D.T., et al., Nature, 366, 562 (1993). RYANODINE, 9,21-DEHYDRO 2. Mery, P.-F., et al., J. Biol. Chem., 268, See: 9,21-Dehydroryanodine 26286 (1993). C6H10N4O2 • HCl MW 206.7 -S- SIN-10 SACLOFEN See: Molsidomine See: 3-Amino-2-(4-chlorophenyl)propanesulfonic acid SK & F 525A 250 mg 103.20 159202 [62-68-0] 1 g 366.90 SANGUINARINE CHLORIDE 5 mg 27.90 RT (Proadifen) 156581 [5578-73-4] 25 mg 92.15 Hydrochloride RT Sodium, potassium and Purity: 99% magnesium-ATPase inhibitor Inhibits cytochrome P450. C20H14NO4Cl MW 367.8 C23H31NO2 • HCl MW 389.9 SC-9 SK & F 91488 1 mg 13.75 See: 5-Chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide 159775 [68643-23-2] 5 mg 42.40 0-5oC (4-[N,N-Dimethylamino]butylisothiourea 25 mg 169.70 dihydrochloride) SC-10 A Dimaprit homologue. Strong inhibitor of See: 5-Chloro-N-Heptylnaphthalene-1-sulfonamide histamine N-methyltransferase. C7H17N3S • 2HCl MW 248.2 1 g 43.35 (-)-SCOPOLAMINE SK & F 96365 5 mg 109.20 153560 Hydrobromide 5 g 130.15 β 0-5oC A cholinergic antagonist. 158992 (1-[ -[3-(4-Methoxyphenyl)propoxy]- 10 mg 215.00 C H NO • HBr MW 384.3 RT 4-methoxyphenethyl]-1H-imidazole) 25 mg 535.00 17 21 4 Hydrochloride (-)-SCOPOLAMINE n-BUTYL 1 g 43.35 Purity: 98% 153561 BROMIDE 5 g 130.15 Specifically inhibits receptor-mediated 0-5oC [149-64-4] calcium entry in platelets, neutrophils, and A cholinergic antagonist. endothelial cells. C21H30BrNO4 MW 440.4 Ref.: 1. Merrit, J.E., et al., Biochem. J., 271, 515 (1990). 2. Fasolato, C., et al., J. Biol. (-)-SCOPOLAMINE METHYL BROMIDE 250 mg 28.85 Chem., 265, 20351 (1990). 3. Blayney, 153562 [155-41-9] 1 g 57.80 L.M., et al., Biochem. J., 273, 803 (1991). 4. RT (Methscopolamine bromide) Chan, J. and Greenberg, D.A., Biochem. A cholinergic antagonist. Biophys. Res. Commun., 177, 1141 (1991). C18H24BrNO4 MW 398.3 C22H26N2O3 • HCl MW 402.9

To place an order: (800) 854-0530, fax (800) 334-6999 1218 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ SK & F 97541 5 mg 95.00 SPERMINE bis(NITRIC 1 mg 10.50 158830 [127729-35-5] 25 mg 395.00 193716 OXIDE)ADDUCT 5 mg 26.25 RT (3-Aminopropyl-(methyl)phosphonic acid) -20oC [136587-13-8] 25 mg 99.75 Purity: ≥98% (Spermine NONOate; SPER/NO; GABAB agonist, 10 fold more potent than (Z)-1-[N-(3-Ammoniopropyl)-N-[4-(3-aminopr baclophen. opylammonio)butyl]amino]- Ref: 1. Seabrook, G.R., et al., Brit. Jour. of diazen-1-ium-1,2-diolate) Pharmacol., 101(4) 949-957 (1990). Purity: ≥98% 2. Saccomano, N.A., et al., Annu. Rev. A nitric oxide donor that releases nitric Med. Chem., 24 287 (1989). oxide (NO) into aqueous solutions. C11H11NO4 MW 137.1 Ref.: Keefer, L.K., et al., Methods in Enzymol., 268, 281-293 (1996). SODIUM NITROPRUSSIDE 25 g 12.65 C10H26N6O2 MW 262.4 152061 [13755-38-9] 100 g 38.50 RT (Sodium nitroferricyanide) 250 g 85.50 SPHINGOMYELIN 5 mg 8.25 Crystalline 500 g 143.85 102945 [85187-10-6] 10 mg 11.70 Reagent used for chromatographic 0oC From Bovine Brain 50 mg 33.30 detection of peptides containing cystine. Purity: ∼99% 100 mg 65.00 Also liberates nitric oxide in biological White powder 500 mg 320.00 systems. Primarily contains stearic and nervonic Na2Fe(CN)5NO MW 261.9 acids. Used in the preparation of vesicles. Ref.: Parmar, Y.I., et al., J. Am. Chem. SODIUM ORTHOVANADATE 10 g 13.20 Soc., 106, 2434 (1984). 159664 [13721-39-6] 25 g 25.25 RT (Decavanadate) 100 g 91.70 µ Purity: 96% min. SPHINGOMYELIN [Choline Methyl- 10 Ci 1068.20 16025 14C] 25 µCi 2363.65 Powder o Potent alkaline phosphate inhibitor. 0-5 C From Bovine Na3VO4 MW 183.9 Sp. Act. 50-60 mCi/mmol 1.85-2.22 GBq/mmol SOTALOL 5 mg 40.80 Toluene:methanol (1:1) solution. 193715 [3930-20-9] 25 mg 163.15 Please call for delivery information. RT Hydrochloride A potent β-adrenergic antagonist. SPHINGOMYELIN [Choline Methyl-3H] 50 µCi 1068.20 C12H20N2O3S • HCl MW 272.4 26053 From Bovine 0-5oC Sp. Act. 60-90 Ci/mmol SPANTIDE II 1 mg 172.00 2.22-3.33 TBq/mmol 158736 (N-ε-Nicotinoyl-D-Lys-Pro-3-Pyridyl-Ala-Pro-D Toluene:methanol (1:1) solution. o -20 C -Cl2-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH2 Please call for delivery information. Purity: >97% Potent Substance P antagonist. D-erythro-SPHINGOSINE 1 mg 13.75 Ref.: Folkers, K., et al., Amino Acids, 5, 233 159665 [123-78-4] 5 mg 44.65 (1993). 0oC (Cerebroside) 25 mg 145.00 MW 1670.2 Synthetic Inhibits Protein Kinase C and SPECTINOMYCIN 1 g 13.75 calmodulin-dependent enzymes. 158993 (U 18409E, antibiotic) 2 g 22.95 C18H37NO2 MW 299.5 0-5oC Sulfate 5 g 52.15 Purity: 98% 3 µ C H N O • H SO MW 430.4 D-erythro-SPHINGOSINE, [3- H] 50 Ci 726.45 14 24 2 7 2 4 26050 Sp. Act. 15-30 Ci/mmol 250 µCi 1817.90 0-5oC 0.555-1.11 TBq/mmol SPERMIDINE 1 g 17.20 Ethanol solution 152068 [124-20-9] 5 g 53.75 o Shipped with Dry Ice. 0-5 C (N-[3-Aminopropyl]-1,4-butanediamine) 25 g 200.75 Please call for delivery information. Free Base MW 299.5 Purity: ∼99% C7H19N3 MW 145.2 SPHINGOSINE-1-PHOSPHATE 1 mg 119.00 158737 [26993-30-6] SPERMIDINE 1 g 13.20 o 100472 [334-50-9] 5 g 37.00 -20 C Purity: 98% 0oC Trihydrochloride 25 g 145.00 A second messenger which mobilizes Crystalline calcium from intracellular stores. Purity: 99% Phospholipase D activator and inhibitor of Forms stable compounds with nucleic acids. tumor cell motility and invasiveness. C H N • 3HCl MW 254.6 Growth promoter of quiescent Swiss 3T3 7 19 3 fibroblasts. 3 Ref.: 1. Mattie, M., et al., J. Biol. Chem., SPERMINE, [Terminal Methylene- H] 1 mCi 787.10 269, 3181 (1994). 26049 Tetrahydrochloride 5 mCi 2666.85 o 2. Desai, N.N., et al., J. Biol. Chem., 267, 0-5 C Sp. Act. 30-60 Ci/mmol 23122 (1992). 1.11-2.22 TBq 3. Sadahira, Y., et al., Proc. Natl. Acad. Sci. Ethanol:water solution (9:1). USA, 89, 9686 (1992). Please call for delivery information. MW 379.5 NH2CH2(CH2)2NH(CH2)4NH(CH2)2CH2NH MW 348.2 SPHINGOSYLPHOSPHORYLCHOLINE 10 mg 155.00 158738 [1670-26-4] SPERMINE 1 g 18.00 o 100474 [306-67-2] 5 g 175.00 -20 C Purity: 98% 0oC Tetrahydrochloride Calcium release inducer. Crystalline Ref.: Yule, D.I., et al., J. Biol. Chem., 268, Purity: 96-98% 12353 (1993). C10H26N4 • 4HCl MW 348.2 C23H49N2O5P MW 464.6

One call. One source. 1219 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ SPIPERONE 100 mg 32.00 STREPTOLYDIGIN 1 mg 13.65 152072 [749-02-0] 250 mg 62.00 158996 [7229-50-7] 5 mg 43.00 0-5oC (Spiropitan; 0-5oC (U 5481) 10 mg 81.40 4-Phenyl-8-[3-(4-fluorobenzoyl)propyl]-1-oxo- Purity: 98% 2,4,8-triazaspiro[4,5]decane) Active against a number of gram positive Selective antagonist for dopamine D2 bacteria. Inhibits the assembly of the RNA receptor. polymerase II transcription complex and C23H26FN3O2 MW 395.5 DNA polymerase III transcription. Ref.: 1. Logan, K., et al., DNA, 8, 595 SPIPERONE 25 mg 21.75 (1989). 2. Logan, K. and Ackerman, S., 153767 [749-02-0] 50 mg 36.15 DNA, 7, 483 (1988). RT (Spiroperidol; 100 mg 65.10 C H N O MW 600.7 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1, 32 44 2 9 3,8-triazaspirol[4,5]decan-4-one) STREPTOMYCIN 5 g 5.55 Hydrochloride 100556 [3810-74-0] 25 g 10.60 o Selective antagonist for dopamine D2 0-5 C Sulfate Salt 50 g 19.30 receptor. White powder 100 g 32.30 C23H26FN3O2 • HCl MW 431.9 Inhibits initiation and causes misreading of 1 kg 305.45 1 mg 13.90 rRNA in protein synthesis. SPIROXATRINE C H N O S MW 1457.4 152404 [1054-88-2] 5 mg 31.25 42 84 14 36 3 0-5oC ((±)-8-[(2,3-Dihydro-1,4-Benzodioxin-2-yl)Me 25 mg 140.75 STREPTOMYCIN SULFATE 5 g 8.25 thyl]-1-Phenyl-1,3,8-Triazaspiro 194541 [3810-74-0] 25 g 16.55 [4,5]Decan-4-one) 0-5oC Cell Culture Reagent 50 g 28.65 A neuroleptic agent for receptor studies. White powder 100 g 39.70 Spiroxatrine has been shown to exhibit high Inhibits initiation and causes misreading of affinity to 5-HT1A binding receptor sites, and rRNA in protein synthesis. moderate affinity to 5-HT1B and 5-HT2 C42H84N14O36S3 MW 1457.4 binding receptor sites. Spiroxatrine has also been shown to exhibit high affinity to STREPTOZOTOCIN 50 mg 13.75 dopamine-D and µ-opiate receptors. 100557 [18883-66-4] 100 mg 22.00 2 o (2-Deoxy-2[([methyl-nitrosoamino]- C22H25N3O3 MW 379.5 0-5 C 500 mg 73.00 carbonyl)-amino]-D-glucopyranose) 1 g 131.00 SQ 22,536 1 mg 27.55 Crystalline 5 g 525.00 193717 [17318-31-9] 5 mg 110.25 Mixed Anomers RT (9-(Tetrahydro-2-furanyl)-9H-purin-6-amine) Potent methylating agent for DNA. An adenylate cyclase inhibitor. Ref.: Bennett, R.A., and Pegg, A.E., C9H11N5O MW 205.2 Cancer Res., 41, 2786 (1981). SQ 29,548 1 mg 66.15 C8H15N3O7 MW 265.2 193718 [98672-91-4] 5 mg 264.60 o STROPHANTHIN G -20 C Potent, selective thromboxane A2 receptor antagonist. See: Ouabain C21H29N3O4 MW 387.5 SUBSTANCE P 0.5 mg 16.60 STAUROSPORINE 100 µg 65.05 152077 [33507-63-0] 1 mg 27.75 191400 [62996-74-1] 500 µg 243.05 -20-0oC (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-M 5 mg 94.50 0-5oC From Streptomyces sp. 1 mg 452.90 2+ et-NH2) 10 mg 187.20 Found to inhibit phospolipid/Ca Ref.: 1. Chang, M., et al., Nature New Biol., dependent and cyclic nucleotide dependent 232, 86 (1971). protein kinases. A potent protein kinase 2. Marx, J.L., et al., Science, 205, 886 inhibitor ueful as a tool for studies on (1979). protein phosphorylation in the regulation of 3. Pernow, B., Pharmac. Rev., 35, 85 cellular functions. (1983). C28H26N4O3 MW 466.5 SUCCINYLCHOLINE CHLORIDE 25 g 26.25 STAUROSPORINE 100 µg 77.70 102975 [71-27-2] 100 g 81.40 194805 [62996-74-1] 500 µg 259.10 o RT Dihydrate 250 g 194.05 0-5 C (Antibiotic AM-2282) 1 mg 468.55 Crystalline 500 g 369.40 From Streptomyces sp. Purity: 98-100% Molecular Biology Reagent C14H30Cl2N2O4 • 2H2O MW 397.3 Purity: ≥98% Inhibitor of phospolipid/Ca2+ dependent and 8-(p-SULFOPHENYL)THEOPHYLLINE 25 mg 25.35 cyclic nucleotide dependent protein 153604 Adenosine antagonist 50 mg 43.35 kinases. A potent protein kinase C inhibitor RT C13H12N4SO MW 336.5 100 mg 79.55 and useful as a tool for studies on protein phosphorylation in the regulation of cellular SULINDAC 1 g 10.50 functions. 195864 [38194-50-2] 5 g 22.00 C28H26N4O3 MW 466.5 RT (Z-5-Fluoro-2-methyl-1-[p-(methlsulfinyl)benz ylidene]indene-3-acetic acid; MK-231; 1-STEAROYL-2-ARACHIDONOYL-sn- 2 mg 17.50 aflodac) 158994 GLYCEROL 5 mg 41.00 Purity: ≥99% -20-0oC [65914-84-3] 10 mg 68.00 Non-steroidal anti-inflammatory which (C18:0/C20:4,[cis,cis,cis,cis]-5,8,11,14; 25 mg 153.00 inhibits cyclooxygenase and prostaglandin 1-octadecanoyl-2-[(cis,cis,cis,cis)-5,8,11,14-e synthesis. Causes adenoma regression by icosatetraenoyl]-sn-glycerol) apoptotic mechanism and induces Purity: 98% apoptosis in HT-29 cells at levels which Protein kinase C activator affect cell proliferation, morphology and cell Ref.: Go, M., et.al., ibid., 144, 598 (1987). phase distribution. C41H72O5 MW 645 C20H17FO3S MW 356.4 1-STEAROYL-2-LINOLEOYL-sn- 20 mg 110.10 SULINDAC SULFIDE 1 mg 10.00 158995 GLYCEROL 50 mg 263.70 196029 [32004-67-4] 5 mg 40.00 -20oC Purity: 98% 100 mg 504.50 RT Purity: ≥99% 25 mg 120.00 Protein kinase C activator. Cyclooxygenase inhibitor but not related to Ref.: Go, M., et.al., ibid., 144, 598 (1987). apoptosis induction. C39H72O5 MW 621 MW 340.4 To place an order: (800) 854-0530, fax (800) 334-6999 1220 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ SULINDAC SULFONE 1 mg 10.00 196030 [59864-04-9] 5 mg 40.00 -T- ≥ RT Purity: ≥99% 25 mg 120.00 TAMOXIFEN 100 mg 14.00 Induces apoptosis but does not inhibit 156738 [10540-29-1] 250 mg 29.00 cyclooxygenase activity. 0-5oC ([Z]-1-[p-Dimethylaminoethoxyphenyl]-1,2-dip 1 g 110.00 MW 372.4 henyl-1-butene) Free Base ± (±)-SULPIRIDE 1 g 28.85 C26H29NO MW 371.5 153569 [15676-16-1] 5 g 86.75 RT (5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- TAMOXIFEN 100 mg 19.00 benzamide) 156739 [54965-24-1] 250 mg 36.00 0-5oC ([Z]-1-[p-Dimethylaminoethoxyphenyl]-1,2-dip 1 g 95.00 D2 Dopamine antagonist C H N O S MW 341.4 henyl-1-butene) 15 23 3 4 Citrate Salt 10 mg 45.55 Protein Kinase C inhibitor R(+)-SULPIRIDE C H NO • C H O MW 563.6 153605 [23756-79-8] 15 mg 65.10 26 29 6 8 7 o 0-5 C C15H23N3O4S MW 341.4 25 mg 101.25 TAU 0.1 ml 225.00 638032 S(-)-SULPIRIDE 10 mg 45.55 o MONOCLONAL ANTIBODY 153606 [23672-07-3] 15 mg 65.10 -20 C Anti-Bovine RT antidepressant. 25 mg 101.25 Clone: TAU-2 (S(-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolod Isotype: mouse IgG1 inyl)-methyl]-2-methoxybenzamide) Conc/Titer: 1:1,000 D2 Dopamine antagonist Applications: Immunoblotting C15H23N3O4S MW 341.4 This product reacts exclusively with the chemically heterogenous Tau in both the SURAMIN 50 mg 30.35 phosphorylated and non-phosphorylated 159021 [129-46-4] 200 mg 66.00 from. It does not react with MAP’s or RT Sodium Salt 500 mg 153.00 tubulin, and it localizes Tau along Purity: 98% microtubules found in axons, somata, Various growth factor inhibitor. Protein G dendrites, astocytes, as well as, along uncoupler from receptors through ribosomes. It will stain Tau in the Alzheimer interaction with intracellular domains. A neurofibrillary tangles on formalin fixed strong competitive reverse transcriptase paraffin embedded sections of human brain inhibitor. Also demonstrates T-lymphocyte tissue. It demonstrates reactivity with protection against HIV infection. Strongly human, bovine, monkey and chicken cells inhibits melanoma heparanase and tumor or tissues. cell metastasis. Ref.: 1. Huang, R.-R.C., et al., Mol. TAU 0.5 ml 330.00 Pharmacol., 37, 304 (1990). 2. Hosang, M., 657842 POLYCLONAL ANTIBODY J. Cell Biochem., 29, 265 (1985). 3. -20oC Anti-Chicken Nakajima, M., et al., J. Biol. Chem., 266, Host: rabbit 9661 (1991). 4. Mitsuya, H., et al., Science, Form: pooled delipidized antiserum 226, 172 (1984). Conc/Titer: 1:100 C51H34N6O23S6Na6 MW 1429.2 Applications: Western blots; dot immunobinding SWAINSONINE 0.5 mg 50.00 This antibody is produced by repeated 154250 [72741-87-8] 1 mg 96.00 injections of tau proteins from chick embryo 0-5oC Purity: ≥98% 5 mg 477.00 brain. The antiserum is evaluated for α-Mannosidase inhibitor specificity and potency by C8H15NO3 MW 173.1 immunoenzymatic labeling procedures. It will not stain MAP1, MAP2, or tubulin. SYNDYPHALIN-20 0.5 mg 39.00 152840 [82598-04-7] 1 mg 65.10 -20-0oC (Syndyphalin SD-25; 5 mg 267.60 TAXOL Tyr-D-Met(S=O)-Gly-Phe-ol) A Registered Trademark for Paclitaxel A highly selective ligand for the µ-opiate receptor. Ref: Kiso, Y., et al., Naturwissenschaften, ψ-TECTORIGENIN 250 µg 137.60 68, 210 (1981). 159667 [13111-57-4] 0-5oC Inhibits EGF-receptor Tyrosine Kinase, SYNTHALIN 5 mg 51.60 which in turn blocks phosphatidylinositol 158740 [111-23-9] 10 mg 82.60 turnover. RT (N,N′-1,10-Decanediyl-bis(guanidine) 25 mg 177.70 Ref.: Imoto, M., et al., J. Antibiotics, 44, 915 sulfate) (1991). Sulfate Salt C16H12O6 MW 300.3 Purity: 99% NMDA receptor polyamine site competitive R-(+)-TERGURIDE 5 mg 22.05 antagonist. 193719 [37686-84-3] 25 mg 88.20 Ref.: Reynolds, I.J., et al., J. Pharmacol. RT (trans-Dihydrolisuride) Exp. Ther., 259, 626 (1992). The dehydrogenated analog of lisuride. A MW 354.5 partial dopamine receptor agonist. C20H28N4O MW 340.5 SYNTIDE 2 1 mg 128.40 159666 (Calmodulin-Dependent Protein Kinase o S-(-)-TERGURIDE 5 mg 22.05 0 C Substrate) 193720 [37686-85-4] 25 mg 88.20 Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu RT Maleate Salt -Pro-Gly-Lys-Lys Acts as both a dopamine receptor agonist A selective substrate for and antagonist. calmodulin-dependent protein kinase II. C H N O • C H O MW 456.5 MW 1507.8 20 28 4 4 4 4

One call. One source. 1221 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ TETANUS TOXIN 10 µg 496.10 THEOPHYLLINE, [8-14C] 250 µCi 969.00 193963 From Clostridium tetani 16026 Sp. Act. 40-60 mCi/mmol 1 mCi 1937.00 -20oC A potent inhibitor of neurotransmitter 0-5oC 1.48-2.22 GBq/mmol release with relative selectivity for GABA Ethanol solution. and Glycine. It also specifically cleaves Please call for delivery information. synaptobrevin 2 which causes inhibition of MW 180.17 neurotransmitter release. 3 Ref.: Matsuda and Yoneda, Infection and THEOPHYLLINE, [8- H] 1 mCi 1068.20 26051 Sp. Act. 10-20 Ci/mmol Immunity, 12, 1147 (1975). o MW 150 kDa 0-5 C 370-740 GBq/mmol Ethanol solution. TETRAETHYLAMMONIUM CHLORIDE 25 g 14.75 Please call for delivery information. 153542 [56-34-8] 100 g 40.00 MW 180.17 RT A potassium channel blocker C8H20ClN MW 165.7 2-(1-THIENYL)ETHYL-3,4- 1 mg 13.75 159669 5 mg 41.25 o DIHYDROXYBENZYLIDENE- 6,7,8,9-TETRAHYDRO-5[H]- 5 mg 24.10 0 C CYANOACETATE 25 mg 188.00 158741 BENZOCYCLOHEPTENE-5-OL-4- 10 mg 38.45 [132465-10-2] RT YLIDENE ACETIC ACID 50 mg 154.75 Purity: 99% [131733-92-1] Inhibits 12-lipoxygenase. (NCS 382) C16H13NO4S MW 315.3 Sodium Salt Purity: 98% L-THIOCITRULLINE 1 mg 12.10 Antagonist for γ-hydroxybutyrate (GHB) 195065 [156719-37-8] 5 mg 38.60 which blocks sedative and catalytic effects. -20oC Purity: ≥97% 25 mg 148.85 Ref.: 1. Hechler, V.D., et al., J. Potent and stereo-specific heme-binding Neurochem., 49, 1025 (1991). inhibitor of brain, endothelial, and inducible 2. Schmidt, C., et al., Eur. J. Pharmacol., smooth muscle isoforms of nitric oxide 203, 393 (1991). synthase. Ref.: Narayanan, K. and Griffith, O.W., J. (6R)-5,6,7,8-TETRAHYDRO- 25 mg 101.25 Med. Chem., 37, 855 (1994). 153622 50 mg 187.95 L-BIOPTERIN C6H13N3O2S MW 191.3 -20oC [17528-72-2] 100 mg 361.50 Dihydrochloride THIOMUSCIMOL 10 mg 306.35 A co-factor for nitric oxide synthase 152129 Free base 25 mg 425.45 o C9H15N5O3 • 2HCl MW 314.2 0-5 C Crystalline GABAA receptor agonist TETRAHYDROCANNABINOL-7-OIC 1 mg 200.65 Ref.: Krogsgarrd-Larsen, et al., J. 159199 ACID 5 mg 888.60 Neurochem., 32, 1717 (1978) 0oC [39690-06-7] (11-nor-8-Tetrahydrocannabinol-9-carboxylic THIOPERAMIDE 5 mg 53.90 acid) 158754 [106243-16-7] 10 mg 89.40 Purity: 98% RT (N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinec 25 mg 195.50 A tetrahydrocannabinol metabolite with arbothioamide) bronchodilatory, anti-inflammatory and Maleate Salt analgesic properties. Acts as a platelet Purity: ≥98% activating factor antagonist and blocks Selective and potent antagonist of leukocyte adhesion. histamine H3. Ref.: 1. Burstein, S., et al., FASEB J., 2, Ref.: 1. Arrang, J.M., et al., Nature, 327, 3024 (1988). 2. Burstein, S., et al., J. 117 (1987). Pharmacol. Exp. Ther., 251, 531 (1989). 3. 2. LaBelle, F.S., et al., Brit. J. Pharmacol., Burstein, S., et al., Biochem. Pharmacol., 107, 161 (1992). 35, 2553 (1986). C15H24N4SC4H4O4 MW 408.5 MW 344.4 THIORIDAZINE 1 g 18.35 9-(TETRAHYDRO-2-FURANYL)-9H-PURIN-6-AMINE 156891 [130-61-0] 5 g 40.00 RT (10-[2-(1-Methyl-2-piperidyl)-ethyl]-2-[methylt 25 g 170.00 See: SQ 22,536 hiol]-phenothiazine) THAPSIGARGICIN 1 mg 149.00 Hydrochloride 159668 [67526-94-7] 5 mg 596.00 Purity: 98% 0oC Purity: 99% Calcium channel antagonist. Also a dopamine antagonist. Less potent analog of Thapsigargin. It has • an n-hexanoate ester rather than C21H26N2S2 HCl MW 407 n-octanoate on the 2-OH. DL-THIORPHAN 1 mg 21.00 C32H46O12 MW 622.70 152841 [76721-89-6] 5 mg 72.10 o THAPSIGARGIN 1 mg 69.50 -20-0 C ([DL-3-Mercapto-2-benzyl- 25 mg 337.50 158999 [67526-95-8] 5 mg 236.50 propanoyl]-glycine) -20oC Purity: 99% A potent and specific enkephalinase Cell permeable sesquiterpene lactone inhibitor with antinociceptive activity. tumor promoter. Inhibits endoplasmic Ref: 1. Roques, B.P., et al., Nature, 288, reticulum Ca2+-ATPase which induces the 286 (1980). release of independent intracellular Ca2+. 2. Roques, B.P., et al Life Sci., 31, 1749 Ref.: 1. Fujiki, H., et al., Carcinogenesis, 7, (1982). 707 (1986). 2. Takemura, H., et al., J. Biol. 3. Evans, D.A., et al., J. Org. Chem., 50, Chem., 264, 12266 (1989). 3. Thastrup, O., 1830 (1985). et al., Proc. Natl. Acad. Sci. USA, 87, 2466 C12H15NO3S MW 253.3 (1990). THIOTHIXENE 25 mg 18.05 C34H50O12 MW 650.8 153603 [5591-45-7] 50 mg 28.85 THEOPHYLLINE 100 g 15.50 RT (N,N-Dimethyl-9-[3-(4-methyl- 100 mg 52.00 103024 [58-55-9] 250 g 34.00 1-piper-azinyl) propylidene]thio- RT (1,3-Dimethylxanthine) 500 g 61.70 xanthene-2-sulfonamide) Crystalline 1 kg 92.45 Hydrochloride Anhydrous D1/D2 Dopamine antagonist. • C7H8N4O2 MW 180.2 C23H29N3O2S2 HCl MW 480.1 To place an order: (800) 854-0530, fax (800) 334-6999 1222 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ THIP 10 mg 31.80 TRIACSIN C 100 µg 262.50 153602 [64603-91-4] 15 mg 45.55 195851 [76896-80-5] 1 mg 1044.75 0-5oC (Gaboxadol; 4,5,6,7-Tetra- 25 mg 72.25 -20oC Purity: ∼90% hydroisoxazolo[5,4-c]pyridin-3-ol) Selectively inhibits arachidonoyl-CoA Hydrochloride synthetase in intact cells and the Post synaptic GABA receptor agonist non-specific acyl-CoA synthetase in cell C6H8N2O2 • HCl MW 176.5 sonicates. MW 207.3 THYMELEATOXIN 1 mg 310.00 159000 [94402-56-1] TRIAMTERENE 10 g 24.00 -20oC Purity: 99% 156960 [396-01-0] 25 g 48.00 Diterpene isolated from Thymelea hirsuta L. RT Purity: 98% which specifically activates α, β, γ-PKC Sodium channel blocker isozymes over δ and ε isozymes. C12H11N7 MW 253.3 C36H36O10 MW 628.7 TRICYCLODECAN-9-YL 1 mg 22.00 195683 XANTHOGENATE 5 mg 104.00 TIMOLOL 100 mg 35.00 -20oC [83373-60-8] 156923 [26921-17-5] 250 mg 77.00 (D609) RT (S[-]-1-[t-Butylamino]-3-(4-morpholino-1,2,5-t 1 g 300.00 Purity: 98% hiadiazol-3-yl)oxy]-2-propanol) Potassium Salt Maleate Salt A selective inhibitor of A β-adrenergic antagonist. • phosphatidylcholine-specific PLC. C13H24N4O3S C4H4O4 MW 432.5 Possesses antitumor and antiviral activity. MW 266.5 TINYATOXIN 500 µg 73.00 159670 [58821-95-7] TRIFLUOPERAZINE 5 g 23.95 0oC Purity: 99% 190089 [440-17-5] 10 g 43.70 Analog of resiniferatoxin (10-[3-(4-Methyl-1-piperazinyl)propyl]-2-trifluo 25 g 78.65 C36H38O8 MW 598.7 romethylphenothiazine) Dihydrochloride TMB-8 Calmodulin antagonist Ref.: R.M. Levin, B. Weiss, J. P. See: 3,4,5-Trimethoxybenzoic acid 8-(diethylamino)-octylester Pharmacol. Exp. Ther., 208, 454 (1978). C21H24F3N3S • 2HCl MW 480.4 TOLAZAMIDE 1 g 7.45 159001 [1156-19-0] 5 g 35.55 1-(2-TRIFLUOROMETHYL- 10 mg 13.65 RT (U 17835; 1-[Hexahydro-1H- 25 g 125.00 193722 PHENYL)IMIDAZOLE 50 mg 52.50 azepin-1-yl]-3-[p-toluenesulfonyl]urea) RT (TRIM) Purity: 98% A potent inhibitor of neuronal and inducible Antidiabetic sulfonylurea that blocks nitric oxide synthase. ATP-sensitive potassium ion channels. Ref.: Handy, et al., Br. J. Pharmacol., 116, Ref.: Schmid-Adomarch, H., et.al., J. Biol. 2349 (1995). Chem., 262, 15840 (1987). C10H7N2F3 MW 212.2 C14H21N3O3S MW 311.4 N-(3-TRIFLUOROMETHYL- 1 g 17.65 TOLBUTAMIDE 25 g 12.50 193723 PHENYL)PIPERAZINE 5 g 52.90 190274 [64-77-7] 100 g 34.00 RT [16015-69-3] RT (3-[p-Tolyl-4-sulfonyl]-1-butylurea) 500 g 112.00 (TFMPP) Crystalline Hydrochloride C12H18N2O3S MW 270.3 A serotonin receptor agonist. C11H13N2F3 • HCl MW 266.7 14 µ TOLBUTAMIDE, [Carbonyl- C] 10 Ci 192.85 TRIFLUPERIDOL 25 mg 36.15 16027 Sp. Act. 50-60 mCi/mmol 50 µCi 459.65 o 153595 [2062-77-3] 50 mg 69.40 0-5 C 1.85-2.22 GBq/mmol 0-5oC (R 2498) 100 mg 130.15 Ethanol solution. 4′-Fluoro-4-[4-hydroxy-4(α,α,α-trifluoro-m-to Please call for delivery information. lyl)piperidino]butyrophenone) CH3C6H4SO2NHCONH(CH2)3CH3 Hydrochloride MW 270.3 Neuroleptic dopamine antagonist C H F NO • HCl MW 445.9 TRACAZOLATE 2 mg 21.75 22 23 4 2 153594 [41094-88-6] 5 mg 43.35 DL-TRIHEXYPHENIDYL 5 g 46.10 RT (4-(Butylamino)-1-ethyl-6-methyl-1H-pyrazolo 10 mg 79.55 157047 [58947-95-8] 10 g 87.20 [3,4-b] pyridine-5-carboxylic acid ethyl ester) RT Hydrochloride C16H24N4O2 MW 304.4 Muscarinic receptor antagonist C20H31NO • HCl MW 337.9 TRANYLCYPROMINE R(-)-2,10,11-TRIHYDROXYAPORPHINE 15 mg 57.80 See: trans-2-Phenylcyclopropylamine 153596 [77630-01-4] 25 mg 94.00 -20-0oC (R(-)-2-Hydroxyapomorphine) 50 mg 173.50 TRAZODONE 1 g 13.00 Hydrobromide 191518 [25332-39-2] 5 g 42.65 Dopamine agonist RT Hydrochloride C17H17NO3 • HBr MW 364.2 A serotonin uptake inhibitor. ′′′ C19H22ClN5O • HCl MW 408.3 4 ,5,7-TRIHYDROXYISOFLAVONE See: Genistein TREQUINSIN 5 mg 84.85 159002 [78416-81-6] 10 mg 146.70 R(-)-2,10,11-TRIHYDROXY-N- 2 mg 25.35 RT (HL 725) 153597 PROPYLNORAPORPHINE 5 mg 50.60 Purity: 98% 0-5oC [77630-02-5] 10 mg 94.00 Specific and extremely potent (TPNA) cGMP-inhibited phosphodiesterase inhibitor. Hydrobromide Ref.: Rupert, D. and Weithmann, K.U., Life 2-OH-NPA Sci., 31, 2037 (1982). D2 Dopamine agonist MW 442 C19H21NO3 • HBr MW 392.3 One call. One source. 1223 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ TRIM TRYPSIN INHIBITOR 250 mg 16.70 100612 [9035-81-8] 500 mg 27.85 See: 1-(2-Trifluoromethylphenyl)imidazole 0-5oC From Chicken Eggwhites 1 g 46.50 Essentially Salt-free 5 g 220.00 3,4,5-TRIMETHOXYBENZOIC ACID 8- 10 mg 20.00 Lyophilized 157064 (DIETHYLAMINO) OCTYL ESTER 50 mg 86.30 1 mg inhibits 1.0-3.0 mg of trypsin. RT [53464-72-5] (TMB-8; 8-(Diethylamino)octyl-3,4,5-trimethoxybenzoa TRYPSIN INHIBITOR 25 mg 19.80 100798 [9035-81-8] 100 mg 60.50 te) o Hydrochloride 0-5 C From Lima Beans 500 mg 180.00 Purity: 98% Salt-free 1 g 350.00 Inhibits intracellular calcium mobilization Lyophilized Ref.: 1. Chiou, C.Y., et al., Br. J. 1 mg inhibits 2.3-3.0 mg. of trypsin. Pharmacol., 553, 279 (1985). 2. Donowitz, Stable: 1-2 years M., et al., Am. J. Physiol., 250, G691 (1986). Ref.: Fraction III: Arch. Biochem. Biophys. 37; 393 (1952). C22H37NO5 • HCl MW 432

TRIMETHYLSEROTONIN IODIDE 1 mg 16.55 TRYPSIN INHIBITOR 25 mg 18.00 193724 (5-HTQ) 5 mg 43.00 o 101113 [9035-81-8] 100 mg 45.00 0-5 C A quaternary analog of serotonin, which 10 mg 77.15 0oC From Soybean 250 mg 85.00 acts as a 5-HT3 serotonin receptor agonist. Chromatographically prepared, lyophilized, 500 mg 135.00 C13H19N2OI MW 346.2 salt free 1 g 240.00 Activity: >10,000 BAEE units of 5 g 950.00 3-(TRIMETHYLSILYL)-1- 500 mg 15.85 inhibition/mg material 157097 1 g 25.40 o PROPANESULFONIC ACID Unit Definition: One unit will inhibit one 0-5 C [2039-96-5] 5 g 117.40 unit of Trypsin activity (BAEE). (DSS; 2,2-Dimethyl-2-silapentane-5-sulfonate) Sodium Salt TUBULOZOLE C 5 mg 37.00 Purity: 99% 159003 [84697-22-3] 25 mg 130.00 Crystalline RT (R 46846) C6H15O3SSiNa MW 218.3 Hydrochloride Purity: 99% 1,3,9-TRIMETHYLXANTHINE 25 mg 17.35 Blocks tubulin polymerization. 153591 [519-32-4] 50 mg 28.85 Ref.: 1.Van Ginckel, R., et al., Eur. J. RT (Isocaffeine; 100 mg 50.60 Cancer Clin. Oncol., 20, 99 (1984). 2. 2,6-Dihydroxy-1,3,9-trimethylpurine) Geuens, G.M.A., et,al., Cancer Res., 45, C8H10N4O2 MW 194.2 733 (1985). C23H23N3O4SCl2 • HCl MW 544.9 TRIPELENNAMINE 25 g 36.00 157112 [154-69-8] 100 g 126.00 RT (2-[Benzyl(2-dimethylamino- TUBULOZOLE T 5 mg 35.00 ethyl)amino]pyridine) 159004 (R 64181) 25 mg 118.00 Hydrochloride RT Purity: 99% Crystalline An inactive trans-isomer of Tubulozole C. C23H23N3O4SCl2 • HCl MW 544.9 An H1 histamine receptor antagonist. C16H21N3 • HCl MW 291.8 TUNICAMYCIN 1 mg 17.10 TRIPROLIDINE 5 g 33.45 150028 [11089-65-9] 5 mg 56.90 157116 [6138-79-0] 25 g 137.20 o o 0-5 C From Streptomyces sp. 10 mg 95.15 0-5 C (trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]p Antibiotic yridine) Inhibits many biochemical functions such Hydrochloride as synthesis of glycoproteins, procollagen H1 Histamine antagonist • and peptidoglycans; and IgA and IgE C19H22N2 HCl MW 314.9 secretion by plasma cells. Also affects the fibroblast interferon-cell system. TROLEANDOMYCIN 1 g 18.20 MW 840.0 157143 [2751-09-9] 5 g 77.00 RT (Oleandomycin triacetate) 25 g 380.00 Purity: 98% TYROSINE PHOSPHORYLATION SITE 1 mg 82.70 Inhibits cytochrome P-450 mediated nitric 193727 INHIBITOR PEPTIDE 5 mg 330.75 G o oxide release from N -hydroxy-L-arginine. 0-5 C Gly-Ser-Phe-Leu-Val-Arg-Glu-Ser C41H67NO15 MW 814 Blocks binding at phosphorylated tyrosine sites. 3-TROPANYL-3,5- 25 mg 17.35 MW 894.0 153592 DICHLOROBENZOATE 50 mg 28.85 0-5oC [40796-97-2] 100 mg 50.60 (MDL 72222) bis-TYRPHOSTIN 1 mg 13.75 159556 Purity: 99% 5 mg 41.25 5-HT3 serotonin antagonist o C15H17Cl2NO2 MW 314.2 0-5 C Inhibitor of protein tyrosine kinases. 25 mg 151.35 C23H20N4O6 MW 448.4 3-TROPANYL INDOLE-3- 10 mg 27.55 193725 50 mg 110.25 o CARBOXYLATE TYRPHOSTIN A1 20 mg 62.65 0-5 C [89565-68-4] 158818 [2826-26-8] 100 mg 250.40 Hydrochloride RT Purity: >99% A selctive 5-HT3 serotonin receptor An inactive tyrphostin which may be used anyagonist. as a negative control in tyrosine kinase • 1 C17H20N2O2 HCl MW 320.8 inhibition assays . Ref: TRP-NLE-ARG-PHE AMIDE 1 mg 30.80 1. Gazit, A., et al., (1989), J. Med. Chem., 153185 [83903-33-7] 5 mg 135.00 o 32, 2344. -20-0 C A molluscan cardioexcitatory neuropeptide 10 mg 260.00 C11H8N2O MW 184.2 analog.

To place an order: (800) 854-0530, fax (800) 334-6999 1224 www.icnbiomed.com Outside the U.S.: (714) 545-0100, fax (714) 557-4872 Email: [email protected] Neuroscience Products

CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ TYRPHOSTIN A9 50 mg 71.40 TYRPHOSTIN A48 5 mg 13.75 158819 [10537-47-0] 250 mg 284.25 159679 (3-Amino-2,4-dicyano-5-[4′-hydroxyphenyl]pe 25 mg 51.60 RT (RG-50872) 0-5oC nta-2,4-dienonitrile) 100 mg 183.45 Purity: >99% Purity: 99% Tyrphostin 9 is a selective inhibitor of the C13H8N4O MW 236.2 PDGF receptor tyrosine kinase (IC50=1.2 µM)1,2. It is also a potent (10 nM) uncoupler 3 TYRPHOSTIN A51 5 mg 86.35 of oxidative phosphorylation . 158823 [122520-90-5] 25 mg 340.60 Ref: RT Purity: >99% 1. Levitzki, A. and Gilon, (1991), Trends A potent inhibitor of EGF receptor kinase Pharmacol. Sci., 12, 171. activity. Inhibition is mixed competitive with 2. Bilder, G.E., et al., (1991), Am. J. ATP and substrate1,2,3. Physiol., 260, C721. Ref: 3. Terada, H., (1981), Biochem. Biophys. 1. Gazit, A., et al., (1989), J. Med. Chem., Acta, 639, 225. 32, 2344. C18H22N2O MW 282.4 2. Yaish, P., et al., (1988), Science, 242, 933. TYRPHOSTIN A10 5 mg 86.00 3. Lyall. R.M., et al., (1989), J. Biol. Chem., 193728 (AG-126) 25 mg 328.55 242, 933. RT Purity: >99% C13H8N4O3 MW 268.2 Inhibits tyrosine kinase-dependent B-cell receptor signalling. Also reported to prevent TYRPHOSTIN A63 1 mg 13.75 septic shock in mice. 159680 [5553-97-9] 5 mg 42.40 Ref.: 1. Sarmay, G., et al., Proc. Natl. Acad. 0-5oC ([4-Hydroxybenzyl]malononitrile) 25 mg 169.70 Sci. USA, 91, 4140 (1994). Purity: 99% 2. Roifman, C.M. and Wong, G., J. Useful as a negative control. Immunol., 149, 1179 (1992). C10H8N2O MW 172.2 C10H5N3O3 MW 215.3 TYRPHOSTIN B7 2 mg 106.70 TYRPHOSTIN A23 10 mg 73.80 158816 (AG-370) 158820 [118409-57-7] 50 mg 300.55 0oC AG-370 is a member of the tyrphostin RT (RG-50810) family of tyrosine kinase inhibitors and is a Purity: >99% selective inhibitor of the PDGF receptor A potent inhibitor of EGF receptor kinase µ 1,2,3 kinase (IC50=20 M) versus the EGF activity . receptor kinase1. Ref: Ref: 1. Gazit, A., et al., (1989), J. Med. Chem., 1. Levitzki, A. and Gilon C. (1991) Trends 32, 2344. Pharmacol. Sci., 12: 171. 2. Lyall, R.M., et al., (1989), J. Biol. Chem., 2. Levitzki, A. et al. (1991) Methods 264, 14503. Enzymol., 201: 370. 3. Yaish, P., et al., (1988), Science, 242, 933. 5 mg 44.10 C TYRPHOSTIN B42 10H6N2O2 MW 186.1 193729 (AG-490; 10 mg 82.70 0-5oC N-Benzyl-3,4-dihydroxy-α-cyanocinnamide) 25 mg 165.35 TYRPHOSTIN A25 5 mg 75.05 Purity: >99% 158821 [118409-58-8] 25 mg 300.55 A protein tyrosine kinase inhibitor. RT (RG-50875) C17H14N2O3 MW 294.3 Purity: >99% A potent inhibitor of EGF receptor kinase 1,2,3 TYRPHOSTIN B46 5 mg 44.10 activity . 193731 (AG-555; 10 mg 82.70 Ref: 0-5oC α 25 mg 165.35 1. Gazit, A., et al., (1989), J. Med. Chem., N-(3-Phenylpropyl)-3,4-dihydroxy- yanocinn 32, 2344. amide) 2. Bilder, G.E., et al., (1991), Am J. Physiol., Purity: >99% 260, C721. A protein tyrosine kinase inhibitor. 3. Yaish, P., et al., (1988), Science, 242, C19H18N2O3 MW 322.4 933. C10H6N2O3 MW 202.1 TYRPHOSTIN B48 10 mg 62.65 158817 (AG-494) 50 mg 250.40 RT Purity >99% TYRPHOSTIN A46 5 mg 17.20 AG-494 is a member of the tyrphostin 159678 [122520-85-8] 25 mg 57.35 o α family of tyrosine kinase inhibitors and is a 0-5 C (3,4-Dihydroxy- -cyanocinnamide) 100 mg 194.95 potent inhibitor of EGF receptor Purity: 99% auto-phosphorylation (IC-50=1.2 µM) and Inhibitor of EGF receptor tyrosine kinase 1 EGF-dependent cell growth (IC50=6µM) . activity. MW 280.3 C10H8N2O3 MW 204.2 Ref: 1. Levitzki, A. et al. (1991) Methods TYRPHOSTIN A47 5 mg 86.35 Enzymol., 201: 370. 158822 [122520-86-9] 25 mg 340.60 RT (RG-50864) TYR-PRO-LEU-GLY AMIDE 5 mg 10.30 Purity: >99% 152960 ([Tyr6]-Oxytocin, Fragment 6-9; Tyr-MIF-1; 25 mg 46.00 A potent inhibitor of EGF receptor kinase o 1,2,3 -20-0 C Tyr-Melanocyte-stimulating activity . Hormone-Release Inhibiting Factor) Ref: This C-terminal tripeptide of oxytocin, has 1. Gazit, A., et al., (1989), J. Med. Chem., activity in numerous behavioral tests and 32, 2344. clinical situations. This compound has 2. Lyall, R.M., et al., (1989), J. Biol. Chem., antiopiate activity. 264, 14503. Ref: 1. Zadina, J.E., et al, Pharmacol. 3. Yaish, P., et al., (1988), Science, 242, Biochem. Behav., 17, 1193 (1982). 933. 2. Kasin, A.J., et al., Pharmacol. Biochem. C10H8N2O2S MW 220.2 Behav., 23, 1045 (1985).

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ [Asu1,6,Arg8]-VASOPRESSIN 0.5 mg 41.45 -U- 152964 [40944-53-4] 1 mg 80.00 o U-0521 20 mg 57.60 -20-0 C (Tyr-Phe-Gln-Asn-Asu-Pro-Arg-Gly-NH2) 158833 [5466-89-7] 100 mg 227.90 Contains bond between Tyr and Asu. RT (3′,4′-Dihydroxy-2-methylpropiophenone) An analog of arginine vasopressin. Purity: > 98% Ref: Hase, S., et al., J. Am. Chem. Soc., Catechol-O-methyltransferase (COMT) 94, 3590 (1972). inhibitor. 1 2 8 Ref: 1. Bryan, L.J., et al., (1983), Naunyn [Deamino-Pen ,O-Me-Tyr ,Arg ]- 0.5 mg 39.85 152967 VASOPRESSIN 1 mg 54.55 Schmiedeberg’s Arch. Pharmacol., 322, 6. o 2. Reches, A. & Fahn, S., (1984), Adv. -20-0 C [67269-08-3] Neurol., 40, 1716. (3-Mercapto-3-methylbutyryl-Tyr[O-Methyl]-P 3. Duncan, P.G., et al., (1985), Eur. J. he-Gln-Asn-Cys-Pro-Arg-Gly-NH2) Pharmacol., 108, 39. Contains disulfide bond between MW 180.2 3-mercapto group and Cys. [β-Mercapto-β,β-cyclopenta- 0.5 mg 45.00 U-10858 152969 1 1 mg 74.80 o methylenepropionyl , See: Minoxidil -20-0 C O-Me-Tyr2,Arg8]-VASOPRESSIN [73168-24-8] U-17835 (Manning Compound; See: Tolazamide [1-Mercaptocyclohexyl]acetyl-Tyr[O-Methyl]-P he-Gln-Asn-Cys-Pro-Arg-Gly-NH2) U-73122 5 mg 65.00 Contains disulfide bond between 159005 [112648-68-7] 10 mg 125.00 mercaptocyclohexyl group and Cys. RT (1-(6-[(17β-3-Methoxyestra-1,3,5-(10)-trien-1 An antagonist of arginine vasopressin. 7-yl)amino]hexyl)-1H-pyrrole-2,5-dione) Ref: Kruszyn i, M., et al., J. Med. Chem., Purity: 98% 23, 364 (1980). Inhibitor of phospholipase C activation in S(-)-VERAPAMIL 2 mg 144.60 human platelets and neutrophils. Inhibits 153587 [36622-28-3] 5 mg 216.95 down regulation of muscarinic receptors. RT C27H38N2O4 • HCl MW 491.0 10 mg 426.65 Ref.: 1. Smith, R.J., et al., J. Pharmacol. Exp. Ther., 253, 688 (1990). 2. Bleasdale, (±)-VERAPAMIL 1 g 29.95 J.E., et al., ibid., 255, 756 (1990). 3. 195545 [52-53-9] 5 g 94.85 Thompson, A.K., et al., J. Biol. Chem., 266, RT Hydrochloride 10 g 170.95 23856 (1991). α1-Antagonist and calcium channel C29H40N2O3 MW 464.7 modulator U-73343 1 mg 58.00 Ref.: Atlas, D. and Adler, M., Proc. Nat. 159006 [142878-12-4] 5 mg 190.00 Acad. Sci. U.S.A., 78, 1237 (1981). C H N O • HCl MW 491.1 RT (1-[6-([17β-3-Methoxyestra-1,3,5 27 38 2 4 (10)-trien-17-yl]amino)hexyl]-2,5-pyrrolidine-d R(+)-VERAPAMIL 2 mg 72.25 ione) 153586 [38176-10-2] 5 mg 144.60 Inactive analog of U73122 which is used as RT Hydrochloride 10 mg 282.05 a negative control. C27H38N2O4 • HCl MW 491.0 Ref.: 1. Smith, R.J., et al., J. Pharmacol. Exp. Ther., 253, 688 (1990). 2. Bleasdale, VERATRIDINE 10 mg 76.95 J.E., et al., ibid., 255, 756 (1990). 159007 [71-62-5] 5x10 mg 380.00 o C29H42N2O3 MW 466.7 -20 C Free Base Purity: 98% U-7984 Activates sodium ion channels. It also prevents inactivation of sodium channels. See: Decoyinine Results in larger negative activation 25 mg 18.00 potentials. URAPIDIL Ref.: 1. leibowitz, M.D., et.al., J. Gen. 193736 [64887-14-5] 100 mg 70.00 Physiol., 87, 25 (1986). 2. Sutro, J. B., ibid., RT Hydrochloride 250 mg 150.00 α 87, 1 (1986). 3. Rando, T.A., et.al., J. An 1-adrenoceptor antagonist and partial Pharmacol. Exp. Ther., 29, 467 (1986). 4. 5-HT1A serotonin receptor agonist. Rando, T.A., J. Gen. Physiol., 93, 43 (1989). C20H29N5O3 • HCl MW 423.9 C36H51NO11 MW 673.8 -V- (±)-VESAMICOL 100 mg 30.30 153588 [120447-62-3] 150 mg 43.40 VALINOMYCIN 5 mg 17.80 0-5oC (AH-5183) 250 mg 68.80 105010 [2001-95-8] 10 mg 29.70 ± o ≥ ( )-2-(4-Phenylpiperidino) cyclohexanol) 0-5 C Purity: 93% 25 mg 52.40 Hydrochloride Crystalline 100 mg 177.85 C H NO • HCl MW 295.5 A metabolite with a broad antibiotic 17 25 spectrum. Inhibitor of mitochondrial action. D-(+)-VESAMICOL 15 mg 68.80 C54H90N6O18 MW 1111.4 153589 [112709-60-1] 25 mg 110.20 0-5oC Hydrochloride 50 mg 206.60 VANCOMYCIN 100 mg 16.35 C H NO • HCl MW 295.5 195540 [123409-00-7] 250 mg 30.65 17 25 o 0-5 C Hydrochloride 1 g 97.85 L-(-)-VESAMICOL 10 mg 62.00 Potency approx. 1000 µg/mg 5 g 384.35 153590 [112709-59-8] 15 mg 89.55 Inhibits bacterial mucopeptide biosynthesis. 0-5oC Hydrochloride 25 mg 137.70 C H NO • HCl MW 295.5 [Arg8]-VASOPRESSIN 0.5 mg 15.20 17 25 152962 [113-79-1] 1 mg 25.20 VINCRISTINE SULFATE 1 mg 34.10 -20-0oC (AVP; Arginine Vasopressin; 5 mg 80.70 190687 [2068-78-2] 5 mg 111.05 Antidiuretic Hormone; 0-5oC Purity: ∼99% 25 mg 496.80 β-Hypophamine; Cys-Tyr-Phe- An anti-tumor alkaloid used in cancer Gln-Asn-Cys-Pro-Arg-Gly-NH2) research. Contains disulfide bond between Cys1 and Ref.: Cancer Res., 38, 4722 (1978). 6 Cys . C46H58N4O14S MW 923

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CATALOG CATALOG NUMBER U.S. $ NUMBER U.S. $ VINPOCETINE 20 mg 64.20 159008 [42971-09-5] 50 mg 153.10 -Z- RT Purity: 98% 100 mg 292.35 ZAPA 10 mg 119.05 Specific Ca2+-calmodulin-dependent 158829 [92138-10-8] 25 mg 261.95 phosphodiesterase inhibitor. RT (Z-3-(Amidinothio)propenoic acid) Ref.: 1. Ahn, H.S., et al., Biochem. Purity: >98% Pharmacol., 38, 33331 (1989). 2. Hagiwara, More potent than either GABA or muscimol M., et al., Biochem. Pharmacol., 33, 453 as an agonist at low affinity GABAA (1984). receptors. C22H26N2O2 MW 350.5 MW 146.2 Ref: -W- 1. ALlan, R.D. et al. (1986) Br. J. Pharmacol. 88: 379. W-5 ZAPRINAST 20 mg 49.90 See: N-(6-Aminohexyl)-1-naphthalenesulfonamide 156931 [37762-06-4] 50 mg 123.00 RT (1,4-Dihydro-5-[2-propoxyphenyl]-7H-1,2,3-tr 100 mg 244.00 W-7 iazolo[4,5d]pyrimidine-7-one; M & B 22948) See: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Purity: 98% Selective cGMP specific W-12 phosphodiesterase inhibitor. See: N-(4-Aminobutyl)-2-naphthalenesulfonamide Ref.: 1. Gillespie, P.G., et al., Mol. Pharmacol., 36, 773 (1989). W-13 2. Burns, F., et al., Biochem. J., 238, 487 (1992). See: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide C13H13N5O2 MW 271.3 WATER, For PCR Applications 1 vial 11.50 ZIMELIDINE 10 mg 39.00 195720 [7732-18-5] 5 vials 42.50 153582 Dihydrochloride 15 mg 54.70 RT 18 Megohm, Sterile Filtered RT Monohydrate 25 mg 86.75 DNase, RNase - None detected Serotonin uptake inhibitor Ideal for use in polymerase chain reactions C16H17N2Br • 2HCl • H2O MW 408.2 (PCR). Each vial = 1.5 ml water. H2O MW 18.02 WB-4101 See: 2-(2,6-Dimethoxyphenoxyethyl)aminomethyl- 1,4-benzodioxane WORTMANNIN 1 mg 30.50 195690 [19545-26-7] 5 mg 120.65 0oC A fungal metabolite which potently and selectively inhibits phosphatidylinositol 3-kinase. It also inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity. C23H24O8 MW 428.4 -X- XANTHINE AMINE CONGENER 2 mg 25.35 153585 [96865-92-8] 5 mg 50.60 RT (XAC) 10 mg 94.00 (8-[4-[[[[(2-Aminoethyl)amino] carbonyl]methyl]oxy]phenyl]-1,3-dipropylxant hine) A1 Adenosine receptor antagonist C21H28N6O4 MW 428.5 XYLAMINE 10 mg 39.00 153581 [57913-68-5] 15 mg 54.70 RT (N-(2-Chloroethyl)-N-ethyl-2-methylbenzylam 25 mg 86.75 ine) Xylamine is a selectively irreversible inhibitor of norepinephrine uptake into central and peripheral noradrenergic neurons. Hydrochloride C12H18ClN • HCl MW 248.2 -Y- YOHIMBINE 1 g 12.30 195546 [65-19-0] 5 g 35.85 RT Hydrochloride 10 g 64.60 Crystalline 25 g 128.65 α2-Adrenergic antagonist 100 g 355.80 C21H26N2O3 • HCl MW 390.9 YS-035 See: N,N-bis(3,4-Dimethoxyphenylethyl)-N-methylamine

One call. One source. 1227 To place an order: (800) 854-0530, fax (800) 334-6999 A world of biomedical products. Outside the U.S.: (714) 545-0100, fax (714) 557-4872