EXPLORING HIDDEN WORLDS  OCTOBER - NOVEMBER 2015

sheffield.ac.uk/krebsfest KREBSFEST THE WORK OF SIR

EXPLORING HIDDEN WORLDS Sir Hans Krebs was The KrebsFest is a celebration of the scientific awarded the research of Sir Hans Krebs, winner of the Nobel Prize in or for Medicine in 1953 for his pioneering work at the in 1953 for discovering . At the festival we will explore the citric acid cycle, Krebs’ legacy through a series of public events and also known as the Krebs exhibitions including talks from Nobel Prize winners. cycle, while working at the University of Sheffield. KrebsFest is open to everyone and it’s free. The cycle explains one All venues are fully accessible. of the most fundamental processes of life: the All events are subject to change. For the latest conversion of food into information, see: sheffield.ac.uk/krebsfest energy within a cell.

For further information: Krebs was born in Hildesheim in northern Germany in 1900. sheffield.ac.uk/krebsfest He followed in his father’s footsteps and studied [email protected] medicine before deciding his future lay in research rather than medical practice. Krebs, who was Jewish, 0114 2220563 left Germany in 1933 after he was dismissed from his post at the University of Freiburg following Hitler’s @UniShefEngage #krebsfest rise to power. He initially worked at the before he took up a post at the University of Sheffield in 1935 where he worked for 19 years.

02 03 KREBSFEST EVENTS

There are lots of exciting, free events taking place during KrebsFest. Find out more about each event further in the brochure.

15 October to Winter Garden Exhibition Pages 8–9 3 November 15 October to Western Bank Exhibition Pages 18–19 early 2016 2 November to Winter Garden Activities Page 9 3 November 9 November Nobel Prize Winner Talk – Page 10 Sir Richard Roberts 13 November KrebsFest Public Night Pages 14–17 18 November Nobel Prize Winner Talk – Page 11 Professor Jules Hoffman 25 November Nobel Prize Winner Talk – Page 11 Sir

AN URBAN RETREAT – INSPIRED BY THE KREBS CYCLE The Krebs cycle and our relationship to the natural environment have inspired the development of proposals for the rejuvenation of the University of Sheffield garden on the corner of Durham Road and Clarkson Street. Sheffield-based artists Owen Waterhouse and David Appleyard are working with Professor Nigel Dunnett of the University’s Department of Landscape to create a garden showcasing the best in urban planting design in combination with a feature artwork that draws people to the space. The proposals are currently in development and we expect A ‘work in progress’ reveal of Dr Florence Blanchard’s to see activity on site during Autumn 2015 – check the Krebs cycle depiction – see page 14. project webpage for regular updates: sheffield.ac.uk/efm/ estatesdevelopment/projects/durhamroad 04 05 TODAY’S CUTTING EDGE RESEARCH THE GRANTHAM CENTRE The Grantham Centre for Sustainable The great legacy of Sir Hans Krebs, both for Sheffield and Futures is an ambitious and innovative the world, is in demonstrating how we can use scientific collaboration between the University methods and understanding to uncover the hidden workings of Sheffield and the Grantham of life. In 1988 the Krebs Institute was established at Foundation for the Protection of the the University of Sheffield. The Krebs Institute brings Environment. Our sustainability research together scientists to build on this legacy in understanding creates knowledge and connects it those mechanisms in biology that underpin life on earth. to policy debates on how to build a fairer world and save Molecular science research at Sheffield is embodied within natural resources for future generations. One example of three projects that describe our vision for the next 10 such research is that undertaken in the Plant Production and years: Imagine, the Grantham Centre and Florey. Protection (P3) centre where world-leading scientists are translating our basic plant and soil sciences research into practical solutions to feed the world’s expanding population. IMAGINE: IMAGING LIFE grantham.sheffield.ac.uk The University of Sheffield is establishing a world-class centre FLOREY INSTITUTE: TACKLING INFECTIOUS DISEASE developing and applying revolutionary microscope technologies, that allow Inspired by the work of Nobel Prize scientists to see the intricate inner winner Sir Howard Florey, we are workings of life in unprecedented striving to save lives by understanding detail. We are using these insights how infective bacteria (pathogens) to unravel how microbes like the MRSA bacteria grow interact with our immune system (the and evade the immune system and how solar energy is host). Sir Howard Florey was a former converted into chemical energy during photosynthesis. Chair of at the University of Sheffield. He went on to carry out the first clinical imagine-imaginglife.com trials for – a drug that saved millions of lives worldwide. Our goal is to solve major issues in infectious diseases – such as anti-microbial drug resistance – through a new, holistic approach to managing infection, that is less reliant on using to kill the bacteria. floreyinstitute.com 06 07 This E. coli is 5 million WINTER GARDEN EXHIBITION times bigger than the real bacterium. If someone Thursday 15 October to Tuesday 3 November was standing next to the 90 Surrey Street, Sheffield S1 2LH bacteria then they would be 2000km tall and stretch With funding from the Arts Council, Dr Nate Adams from the UK to Africa! and Luke Jerram, lead artist for KrebsFest, have collaborated to translate cellular flux and biochemical ORIGAMI INSTALLATION techniques into new artistic pieces to engage the public. Luke Jerram has designed a 28-metre inflatable Seiko Kinoshita is a Japanese artist, based in Sheffield, E. coli bacteria making the nano world larger than life, who uses traditional textile techniques to create which will be dramatically suspended from the ceiling of contemporary artwork and installations. Seiko, working the Winter Garden, Sheffield and then at the University with Dr Nate Adams, has created a visual art installation of Sheffield’s Firth Hall. For KrebsFest, Luke Jerram and using the form and patterns of origami to depict the Dr Adams have taken curatorial and mentorship roles, 3D shape of the green fluorescent protein (GFP) from supporting the development of the two local artist jellyfish. GFP is integral to the cutting edge imaging commissions – Balbir Singh Dance Company (see page 15) techniques being developed in Sheffield. and Seiko Kinoshita (see page 9). ACTIVITIES INFLATABLE E. COLI Monday 2 and Tuesday 3 November, 10am–4pm Making visible the microscopic world around us, this artwork was made to contemplate and consider ATOM-LABS: MACHINES IN MINIATURE the importance of bacteria in our lives. What makes jellyfish glow in the depths of the ocean? What makes egg-whites scary to germs? Although some forms of E. coli bacteria can cause illness Visit the Atom-Labs stand and find out! and even death in humans, the use of the bacteria is vital in medical research. Described as the workhorse of MAKE A BUG biomedicine, E. coli are used by scientists to replicate Inspired by the giant E. coli, young children can make DNA. One of the first useful applications of recombinant their own bug using craft materials with expert input DNA technology was the manipulation of E. coli to from scientists. produce human insulin.

08 09 PROFESSOR JULES HOFFMANN, UNIVERSITY OF NOBEL PRIZE WINNER TALKS STRASBOURG INSTITUTE FOR ADVANCED STUDY THE INNATE IMMUNE RESPONSE: FROM INSECTS TO HUMANS Come and hear three Nobel prize-winners talk about Wednesday 18 November, 6pm incredible scientific discoveries that shape our lives. Awarded the Nobel Prize in Physiology or Medicine in 2011. Book your place at sheffield.ac.uk/krebsfest Insects are a formidable zoological group: they represent an estimated 80% of existing species and put one-third All talks take place in: Firth Hall, Firth Court, of humanity at risk of severe morbidity or deaths through University of Sheffield, Western Bank, S10 2TN their ability to transmit various types of microbes. For a long time, insects have been known to be particularly resistant to infection. Professor Jules Hoffman will discuss his research into the mechanisms underlying this resistance and share results on the unexpected similarities which exist between immune defences in insects and innate immune reactions in mammals. SIR PAUL NURSE, PRESIDENT OF THE ROYAL SOCIETY SIR RICHARD ROBERTS, NEW ENGLAND BIOLABS GREAT IDEAS OF BIOLOGY A CRIME AGAINST HUMANITY Wednesday 25 November, 6pm Monday 9 November, 6pm Awarded the Nobel Prize in Physiology or Medicine in 2001. Awarded the Nobel Prize in Physiology or Medicine in 1993. Three of the great ideas of biology are the gene theory, European non-governmental organisations and politicians the theory of evolution by natural selection, and the have declared that genetically modified organisms (GMOs) are proposal that the cell is the fundamental unit of all life. dangerous despite all scientific evidence to the contrary. When considering the question of ‘what is life?’ these This has led to bans on research on one of the most ideas come together. The special way cells reproduce promising technologies able to solve the world’s food and provides the conditions by which natural selection takes nutrition problems. While Europe doesn’t need GMOs “yet”, place allowing living organisms to evolve. A fourth idea the developing world needs them desperately. One example is is that the organisation of chemistry within the cell Golden Rice, which could be a major player to fight Vitamin A provides explanations for life’s phenomena. A new idea deficiency. Millions of children suffer and die because of this is the central role that information management plays deficiency. Sir Richard Roberts will argue that ignoring the in generating biological organisation. Sir Paul Nurse science underpinning GMOs and its potential to save lives is will discuss how these great ideas have influenced and essentially a crime against humanity. changed the way we think of science today.

10 11 Glass mitochondrion developed by Luke Jerram – see page 14 Balbir Singh Dance Company – see page 15

12 13 installation made by Seiko Kinoshita depicting the 3D shape of KREBSFEST PUBLIC NIGHT green fluorescent protein in jellyfish. Find out more onpage 9.

Friday 13 November, 5–8pm (drop-in) PERFORMANCES Firth Court, University of Sheffield, Western Bank, Sheffield S10 2TN DANCE PERFORMANCE – 5.15PM, 6.15PM AND 7.15PM The Balbir Singh Dance Company will perform short segues Free event aimed at a public audience including families inspired by the motion of the Krebs cycle. Working in and children. Come and explore hidden worlds and see patterns, sequences and numbers, Indian Kathak dance, with things previously invisible to the naked eye! its beauty and intricacy, will bring to life the order and sequence of the Krebs cycle. A live musical score composed ART INSPIRED BY SCIENCE by Jesse Bannister accompanies the performances.

PORTRAITS OUTDOOR FILM SCREENINGS – ALL EVENING View two newly commissioned pieces of artwork made Watch a series of festival films projected on a huge especially for KrebsFest. Portrait artist Keith Robinson scale in Firth Court quad complete with a light show. has painted a striking and modern interpretation of Sir International design agency, Human Studio, have produced Hans Krebs to celebrate one of the greatest scientists of two special films – one about Sir Hans Krebs and one our time. Painter, muralist and screenprinter Dr Florence giving an artistic interpretation of research. Sheffield- Blanchard has created a depiction of the Krebs cycle artist Steve Pool has worked with seven local schools to conveying the complex scientific concepts in a powerful way. create films showing how children are inspired by science.

MITOCHONDRION IMMUNE SYSTEM BATTLE – 5.45PM, 6.45PM AND 7.45PM See a beautiful hand blown glass mitochondrion The epic battle between the immune system and foreign commissioned for the festival. It was developed by invaders is played out constantly in our cells. Duel artist Luke Jerram (see page 8) and is part of the in this multi-player experience in Firth Court quad, artist’s Glass Microbiology series. The artworks are designed by The Good Game Company, to decide whether created as alternative representations of microbiology the body or bacteria will triumph! to the artificially coloured imagery seen in the media. SCIENCE RAP – 5.30PM, 6.30PM AND 7.30PM INFLATABLE E. COLI AND ORIGAMI INSTALLATIONS Learn more about the Krebs cycle through a specially See the unseen! A giant 28 metre inflatable E. coli created commissioned rap performed by Oort Kuiper in Krebs cafe. by artist Luke Jerram displayed in Firth Hall and an origami art continued... 14 15 Use microscopes to observe the transparent embryos, KREBSFEST PUBLIC NIGHT and see the heart pumping and blood circulating.

All activities are suitable for children accompanied by RACING THOUGHTS an adult. ‘3, 2, 1, go go go!’ Control and race a model car with just the power of your brain waves. Do you have what it ACTIVITIES takes to get the fastest time on our drag strip?

WALKING ON CUSTARD LIQUID NITROGEN ICE CREAM You can’t walk on water but you can walk on custard! If you need ice cream in a hurry then liquid nitrogen is Traverse our custard run and find out how nanoscience the fastest, coldest and most exciting way to make it. makes this possible. Come along to Krebs cafe for a taste!

ATOM-LABS: MACHINES IN MINIATURE SEE YOUR HIDDEN WORLD Take a tour of protein and DNA structure on our virtual Use our special microscopes to view cells from your own reality headsets, watch our MakerBot print 3D protein body and uncover your hidden world. models and see how the green fluorescent protein from jellyfish can be used to light up cells. MAKE A BUG Inspired by the giant E. coli, young children can make ATOM-LABS: EXPLORING PROTEIN STRUCTURE IN 3D their own bug using craft materials with expert input Visit our 3D cinema where we investigate the fine detail from scientists. of what goes on inside macromolecules. TALKS ULTRAVIOLET AND INFRARED SELFIES Come and see the infrared emitted from, and the Hear short talks in the Council Room to learn more about: ultraviolet light reflected off, your body using our • SIR HANS KREBS – 5.30pm special cameras and learn about how we use the entire • IMAGINE: IMAGING LIFE RESEARCH PROJECT - 6pm electromagnetic spectrum to reveal hidden worlds. • THE GRANTHAM CENTRE - 6.30pm • FLOREY: TACKLING INFECTIOUS DISEASE - 7pm FISHING FOR CLUES: WHY MEDICAL RESEARCHERS ARE GLOWING WITH EXCITEMENT See pages 3 and 6 to 7 for information on Sir Hans Krebs Learn how scientists at the Bateson Centre work with and these three research projects. zebrafish to study a range of diseases.

16 17 There will be a series of interactive activities and displays WESTERN BANK EXHIBITION including the Robo-plant which simulates the process of photosynthesis. You will get the chance to view the Opens 15 October 2015 unseen world of microbiology through a series of giant Exhibition Gallery, Western Bank Library images from microscopes. There will also be artists’ (next to the Arts Tower), University of Sheffield, representations of molecular life and micro-organisms. Western Bank, Sheffield S10 2TN

OPENING TIMES

Monday to Thursday 9am to 7pm Friday 10am to 7pm Saturday 12pm to 6pm (excluding holidays)

The KrebsFest exhibition is an exciting, free exhibition open to the public. The exhibition will focus on the important scientific discoveries made by Nobel Prize winner Sir Hans Krebs. It will also showcase highlights from the Krebs Institute and its ground-breaking research work. As well as the history of Sir Hans Krebs’ discoveries made at the University, the exhibition will look at the legacy of Krebs and science in Sheffield by examining the current world- class research projects Imagine: Imaging Life, Florey and the Grantham Centre.

The exhibition will use For further information see sheffield.ac.uk/krebsfest historic items relating to Sir Hans Krebs and Contact details: the University, as well [email protected] as scientific research equipment and models. 0114 2227231/7260

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