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CSHL AR 1993.Pdf ANNUAL REPORT 1993 COLD SPRING HARBOR LABORATORY ANNUAL REPORT 1993 Cold Spring Harbor Laboratory Box 100 1 Bungtown Road Cold Spring Harbor, New York 11724 Book design Emily Harste Managing Editor Susan Cooper Editor Dorothy Brown Photography Margot Bennett, Herb Parsons, Edward Campodonico, Scott McBride, Julie Timmins Photo of McClintock Laboratory on inside flyleaf provided by Dick McCombie (CSHL) Typography Marie Sullivan Front cover: McClintock Laboratory (Photograph by Margot Bennett) Back cover: 'Bronze Helix" (Photograph by Bill Geddes) Section title pages: Marlena Emmons Contents Officers of the Corporation/Board of Trustees Governance and Major Affiliations vi Committeesvii Map of CSHLviii DIRECTOR'S REPORT 1 DEPARTMENTAL REPORTS 31 Administration 33 Buildings and Grounds 36 Public Affairs and Development, and the Library 39 RESEARCH 49 Tumor Viruses 51 Molecular Genetics of Eukaryotic Cells85 Genetics133 Structure and Computation 181 Neuroscience209 CSH Laboratory Fellows239 Author Index 243 COLD SPRING HARBOR MEETINGS 245 Symposium on Quantitative Biology249 Meetings 253 EDUCATIONAL ACTIVITIES 279 Postgraduate Courses 281 Seminars319 Undergraduate Research 321 Nature Study 323 BANBURY CENTER 325 Director's Report327 Meetings335 DNA LEARNING CENTER 363 COLD SPRING HARBOR LABORATORY PRESS 383 FINANCIAL STATEMENTS 389 FINANCIAL SUPPORT OF THE LABORATORY 395 Grants397 Capital and Program Contributions 405 Annual Contributions406 LABORATORY STAFF 419 Watson, O.T. Smith, M.D. Lindsay, Standing: E.A.F. Wimmer, G. Cutting, D.L. Luke Ill, D.C. Wiley, J.D. D.A. Warner III, W.R. Miller, G. Blobel, M. Vander Poel Hatch,J.R. Reese, T.J. Knight Sitting: J.A. Steitz, J.J. Phelan, Jr., M.F. Gerry, T.A. Saunders III, L.J.Landeau C.F. Dolan, L.A. Hazen, Not shown: W.M. Cowan, G.R. Fink, T.M. Jessell, J.A. Movshon, S.M. Caldwell Tilghman, D.H. Koch, E.S. Marks, W.S. Robertson, B.D. Clarkson, R.L. Cummings, W.H. Page,H. Bentley Glass Officers of the Corporation David L. Luke III, Chairman Mary D. Lindsay, Vice Chairman John R. Reese, Treasurer Mary Vander Poel Hatch, Secretary Townsend J. Knight, Assistant Secretary James D. Watson, Ph.D., Director Bruce Stillman, Ph.D., Assistant Director G. Morgan Browne, Administrative Director Board of Trustees Scientific Trustees Individual Trustees Gunter Blobel, M.D., Ph.D. Charles F. Dolan John R. Reese Rockefeller University Oyster Bay, New York Cold Spring Harbor, New York Wm. Maxwell Cowan, Ph.D., M.D. Martha Farish Gerry William S. Robertson Howard Hughes Medical Institute Mill Neck, New York Huntington, New York Gerald R. Fink, Ph.D. Mary (Wendy) Vander Poel Hatch Thomas A. Saunders III Whitehead Institute for Biological Oyster Bay, New York Locust Valley, New York Research Lita Annenberg Hazen Owen T. Smith, Esq. New York, New York Laurel Hollow, New York Thomas M. Jessell, Ph.D. Columbia University Townsend J. Knight, Esq. Douglas A. Warner III New York, New York Oyster Bay, New York J. Anthony Movshon, Ph.D. David H. Koch James D. Watson, Ph.D. Howard Hughes Medical Institute, New York, New York Cold Spring Harbor, New York New York University Center for Neural Science Laurie J. Landeau, V.M.D. Northport, New York Joan Argetsinger Steitz, Ph.D. Honorary Trustees Mary D. Lindsay Yale University New York, New York Bayard D. Clarkson, M.D. Shirley M. Caldwell Tilghman, Ph.D. New York, New York David L. Luke III Princeton University New York, New York Robert L. Cummings Glen Head, New York Don Craig Wiley, Ph.D. Edwin S. Marks Harvard University New York, New York Walter H. Page Cold Spring Harbor, New York Eckard A.F. Wimmer, Ph.D. William R. Miller State University of New York, New York, New York H. Bentley Glass, Ph.D. East Setauket, New York Stony Brook John J. Phelan, Jr. New York, New York Governance and MajorAffiliations The Laboratory is governed by a 30-memberBoard of Trustees which meets three between meetings is or four times a year. Authority to actfor the Board of Trustees vested in the Executive Committee of theBoard of Trustees. The Executive Committee is composed of the C fficers of theBoard plus any other members who Additional may be elected to the ExecutiveCommittee by the Board of Trustees. standing and ad hoc committees areappointed by the Board of Trustees to provide guidance and advice in specific are as of theLaboratory's operations. Representation on the Board of Trustees itselfis divided between community representatives and scientists from major researchinstitutions. The Laboratory is chartered as an educationaland research institution by the Board of Regents of the Education Departmentof the State of New York. It is designated as a "public charity" by the InternalRevenue Service. Committees Audit Development Nominating Townsend J. Knight, Chairman David L. Luke III, Chairman Mary D. Lindsay, Chairman Laurie J. Landeau, V.M.D. Wendy V.P. Hatch, Vice Chairman David L. Luke Ill William R. Miller G. Morgan Browne William R. Miller Thomas A. Saunders Ill Susan Cooper John R. Reese Martha F. Gerry Douglas A. Warner Ill Townsend J. Knight Banbury Program Laurie J. Landeau, V.M.D. Mary D. Lindsay Robertson House Eckard A.F. Wimmer, Ph.D., Chairman James D. Watson, Ph.D. William S. Robertson, Chairman Gerald R. Fink, Ph.D. Martha F. Gerry G. Morgan Browne Laurie J. Landeau, V.M.D. Executive Committee Anne Meier J. Anthony Movshon, Ph.D. Jan Witkowski, Ph.D. Jan A. Witkowski, Ph.D. David L. Luke III, Chairman Jack Richards G. Morgan Browne Wendy Vander Poel Hatch Townsend J. Knight Robertson Research Fund Building Mary D. Lindsay Laboratory Representatives Helen A. Dolan, Chairman William R. Miller John R. Reese, Chairman Martha F. Gerry John J. Phelan John R. Reese G. Morgan Browne Wendy Vander Poel Hatch David L. Luke Ill Mary D. Lindsay Bruce Stillman, Ph.D. Bruce Stillman, Ph.D. Jack Richards James D. Watson, Ph.D. James D. Watson, Ph.D. Owen T. Smith Elizabeth Watson Finance and Investment Family Representatives John R. Reese, Chairman Katherine Ernst Commercial Relations G. Morgan Browne Carl Schafer William D. Keen Walter Meier, M.D. William R. Miller, Chairman Townsend J. Knight William S. Robertson Gerald R. Fink, Ph.D. David H. Koch Townsend J. Knight Laurie J. Landeau, V.M.D. David H. Koch David L. Luke III Tenure and Appointments David L. Luke Ill Edwin S. Marks Gerald R. Fink, Ph.D., Chairman John Maroney William R. Miller Gunter Blobel, M.D., Ph.D. Bruce Stillman, Ph.D. William S. Robertson Wm. Maxwell Cowan, M.D., Ph.D. Douglas A. Warner Ill Thomas A. Saunders III Shirley M. Caldwell Tilghman, Ph.D. Don C. Wiley, Ph.D. Joan A. Steitz, Ph.D. (7) (8) 21B (9) 42 (11) (10) (4) 41 22 (5)2 I A (6) 36 2 I C4 I 01 B 33 39IF 30 32 G Bungtown 29 0 35 37 34 Sungtown Rd. To Beach COLD SPRING HARBOR LABORATORY Airslie 37 Fire House 29 Octagon 3 Blackford Hall 10 Fire Hydrants 0 Olney Barn 33 Buildings & Grounds 14 Grace Auditorium 2 Olney House 32 Bush Lecture Hall 9 Harris Building 1 Osterhout 18 Cabin Complex A (1-6) 21A Hershey 7 Pond 31 Cabin Complex B (7-11) 21B Historic Cabins 21C President's House 39 Cairns Laboratory 12 Hooper 17 Pump House 35 Carpenter Shop 13 Ice House 30 Shed 5 Cole Cottage 20 James/Sambrook Laboratory..25 Tennis Courts 38 Davenport House 4 Jones Laboratory 16 Tiffany House 42 DeForest Stables 36 Kurahara House 41 Treatment Plant & Gazebo 27 Delbrtick/Page Laboratory 28 Library 6 Urey 22 Demerec Laboratory 8 McClintock Laboratory 11 Wawepex 15 Dolan Hall 23 Neuroscience Center 24 Williams 19 Double Day 40 Nichols Administration 26 Yellow House 34 DIRECTOR'S REPORT I have now been closely associated with Cold Spring Harbor Laboratory for more than 45 years. During this almost half-century interval, the Lab has both stayed the same and changed itself radically. What initially made me so admire, if not love, the Lab was the beauty of its harbor and buildings, then populated by indi- viduals such as Barbara McClintock and Alfred Hershey, who had extraordinarily high intellectual objectives and standards. There was then, as still today, no snobbery or hypocritical obeisance to age or authority. Instead, what mattered was the truth or falsity of the facts and ideas of genetics. As a 20-year-old sum- mer student, I felt both liked and needed for wanting passionately to unravel the essence of the gene, the master unit of heredity that we now know to be com- posed of DNA. This preoccupation with genetics, which for so long made Cold Spring Harbor Laboratory so unique, goes back to the turn of the century. It was then that Mendel's laws, effectively lost for 35 years, were rediscovered independently by the European plant breeders Correns, de Vries, and Tschermak. In 1904, Cold Spring Harbor became one of the first sites to take on the challenge of the new genetics when money from Andrew Carnegie's steel fortune was used to create a Station for Experimental Evolution here. It was headed by the Harvard-trained zoologist Charles B. Davenport, who was already in charge of a summer teach- ing program at The Biological Laboratory. This neighboring institution had been started in 1890 by the Brooklyn Institute of Arts and Sciences and supported by the local Jones family, one of whose houses adjacent to the Lab was the largest on Long Island until its destruction by fire in 1861. Initially, the main preoccupa- tion of the Station, later to be renamed the Department of Genetics of the Carnegie Institution of Washington, was to extend the validity of Mendel's laws to a large variety of plants and animals including our ownhuman species.
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