Annual Report 2018
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Nilotinib in Patients with Chronic Myeloid Leukemia: STAT2 Trial in Japan
Haematologica HAEMATOL/2018/194894 Version 3 Haematologica HAEMATOL/2018/194894 Version 3 Treatment-free remission after two-year consolidation therapy with nilotinib in patients with chronic myeloid leukemia: STAT2 trial in Japan Naoto Takahashi, Kaichi Nishiwaki, Chiaki Nakaseko, Nobuyuki Aotsuka, Koji Sano, Chikako Ohwada, Jun Kuroki, Hideo Kimura, Michihide Tokuhira, Kinuko Mitani, Kazuhisa Fujikawa, Osamu Iwase, Kohshi Ohishi, Fumihiko Kimura, Tetsuya Fukuda, Sakae Tanosaki, Saori Takahashi, Yoshihiro Kameoka, Hiroyoshi Nishikawa, and Hisashi Wakita Disclosures: 1. This study was supported by research funding from Novartis Pharmaceuticals to N.T. 2. N.T reports grants from Novartis Pharmaceuticals, during the conduct of the study; grants and personal fees from Novartis Pharmaceuticals, grants and personal fees from Otsuka, grants and personal fees from Pfizer, personal fees from Bristol-Myers Squibb, outside the submitted work; K.N reports grants from Zenyaku Kogyo Company, Limited, grants from Chugai Pharmaceutical, grants from Novartis Pharma K.K., grants from Kyowa Hakko Kirin Co, Ltd, grants from Nippon Shinyaku Co, Ltd, outside the submitted work; C.N reports personal fees from Novartis, grants and personal fees from Bristol-Myers Squibb, grants and personal fees from Pfizer, grants and personal fees from Takeda pharmaceuticals, grants and personal fees from Kyowa Hakko Kirin, grants and personal fees from Otsuka Pharmaceutical, grants and personal fees from Ono Pharmaceutical, grants and personal fees from Chugai Pharmaceutical, grants and personal fees from Asahi Kasei Pharma, grants and personal fees from Shionogi, personal fees from Shire, personal fees from Jannsen, personal fees from Celgene, outside the submitted work; M.T. reports personal fees from Bristol-Myers Squib, personal fees from Pfizer, outside the submitted work; K.M reports grants from Kyowa Hakko Kirin Co. -
Japanese Manufacturing Affiliates in Europe and Turkey
06-ORD 70H-002AA 7 Japanese Manufacturing Affiliates in Europe and Turkey - 2005 Survey - September 2006 Japan External Trade Organization (JETRO) Preface The survey on “Japanese manufacturing affiliates in Europe and Turkey” has been conducted 22 times since the first survey in 1983*. The latest survey, carried out from January 2006 to February 2006 targeting 16 countries in Western Europe, 8 countries in Central and Eastern Europe, and Turkey, focused on business trends and future prospects in each country, procurement of materials, production, sales, and management problems, effects of EU environmental regulations, etc. The survey revealed that as of the end of 2005 there were a total of 1,008 Japanese manufacturing affiliates operating in the surveyed region --- 818 in Western Europe, 174 in Central and Eastern Europe, and 16 in Turkey. Of this total, 291 affiliates --- 284 in Western Europe, 6 in Central and Eastern Europe, and 1 in Turkey --- also operate R & D or design centers. Also, the number of Japanese affiliates who operate only R & D or design centers in the surveyed region (no manufacturing operations) totaled 129 affiliates --- 125 in Western Europe and 4 in Central and Eastern Europe. In this survey we put emphasis on the effects of EU environmental regulations on Japanese manufacturing affiliates. We would like to express our great appreciation to the affiliates concerned for their kind cooperation, which have enabled us over the years to constantly improve the survey and report on the results. We hope that the affiliates and those who are interested in business development in Europe and/or Turkey will find this report useful. -
ESG in Japan: Misunderstood & Underestimated
ESG in Japan: Misunderstood & Underestimated Comgest’s investment approach is grounded on thorough fundamental analysis carried out by experienced portfolio managers located in the markets where they invest. Seasoned investors who spend years researching and building relationships with local companies develop an understanding of cultural and regional nuances that are not obvious to outsiders. We believe this leads to perceptive investment insights that few other firms can match. This white paper, authored by Comgest PM Richard Kaye who has spent almost three decades living and investing in Japan, illustrates how experienced local investors can spot opportunities that others miss. Richard Kaye Analyst / Portfolio Manager, Japan Japan is in the process of being rediscovered after a “lost generation” in which it was largely neglected by both domestic Richard Kaye joined Comgest in 2009 and international asset allocators. However, despite the renewed and is a Tokyo-based Analyst and interest in this fascinating and broad market, international investors Portfolio Manager specialising in remain wary of corporate Japan’s ESG credentials. Japanese Japanese equities. With a wealth of companies have a reputation for being behind their global experience in Japanese equities, peers when it comes to ESG activities and transparency. We Richard became co-lead of Comgest’s believe that this characterisation is misleading: many Japanese Japan equity strategy upon joining the companies appear to be ahead of the rest of the world in terms of Group. He started his career in 1994 as environmental technologies and have a deep commitment to their an Analyst with the Industrial Bank of founding vision and social purpose. -
Factset-Top Ten-0521.Xlsm
Pax International Sustainable Economy Fund USD 7/31/2021 Port. Ending Market Value Portfolio Weight ASML Holding NV 34,391,879.94 4.3 Roche Holding Ltd 28,162,840.25 3.5 Novo Nordisk A/S Class B 17,719,993.74 2.2 SAP SE 17,154,858.23 2.1 AstraZeneca PLC 15,759,939.73 2.0 Unilever PLC 13,234,315.16 1.7 Commonwealth Bank of Australia 13,046,820.57 1.6 L'Oreal SA 10,415,009.32 1.3 Schneider Electric SE 10,269,506.68 1.3 GlaxoSmithKline plc 9,942,271.59 1.2 Allianz SE 9,890,811.85 1.2 Hong Kong Exchanges & Clearing Ltd. 9,477,680.83 1.2 Lonza Group AG 9,369,993.95 1.2 RELX PLC 9,269,729.12 1.2 BNP Paribas SA Class A 8,824,299.39 1.1 Takeda Pharmaceutical Co. Ltd. 8,557,780.88 1.1 Air Liquide SA 8,445,618.28 1.1 KDDI Corporation 7,560,223.63 0.9 Recruit Holdings Co., Ltd. 7,424,282.72 0.9 HOYA CORPORATION 7,295,471.27 0.9 ABB Ltd. 7,293,350.84 0.9 BASF SE 7,257,816.71 0.9 Tokyo Electron Ltd. 7,049,583.59 0.9 Munich Reinsurance Company 7,019,776.96 0.9 ASSA ABLOY AB Class B 6,982,707.69 0.9 Vestas Wind Systems A/S 6,965,518.08 0.9 Merck KGaA 6,868,081.50 0.9 Iberdrola SA 6,581,084.07 0.8 Compagnie Generale des Etablissements Michelin SCA 6,555,056.14 0.8 Straumann Holding AG 6,480,282.66 0.8 Atlas Copco AB Class B 6,194,910.19 0.8 Deutsche Boerse AG 6,186,305.10 0.8 UPM-Kymmene Oyj 5,956,283.07 0.7 Deutsche Post AG 5,851,177.11 0.7 Enel SpA 5,808,234.13 0.7 AXA SA 5,790,969.55 0.7 Nintendo Co., Ltd. -
Whither the Keiretsu, Japan's Business Networks? How Were They Structured? What Did They Do? Why Are They Gone?
IRLE IRLE WORKING PAPER #188-09 September 2009 Whither the Keiretsu, Japan's Business Networks? How Were They Structured? What Did They Do? Why Are They Gone? James R. Lincoln, Masahiro Shimotani Cite as: James R. Lincoln, Masahiro Shimotani. (2009). “Whither the Keiretsu, Japan's Business Networks? How Were They Structured? What Did They Do? Why Are They Gone?” IRLE Working Paper No. 188-09. http://irle.berkeley.edu/workingpapers/188-09.pdf irle.berkeley.edu/workingpapers Institute for Research on Labor and Employment Institute for Research on Labor and Employment Working Paper Series (University of California, Berkeley) Year Paper iirwps-- Whither the Keiretsu, Japan’s Business Networks? How Were They Structured? What Did They Do? Why Are They Gone? James R. Lincoln Masahiro Shimotani University of California, Berkeley Fukui Prefectural University This paper is posted at the eScholarship Repository, University of California. http://repositories.cdlib.org/iir/iirwps/iirwps-188-09 Copyright c 2009 by the authors. WHITHER THE KEIRETSU, JAPAN’S BUSINESS NETWORKS? How were they structured? What did they do? Why are they gone? James R. Lincoln Walter A. Haas School of Business University of California, Berkeley Berkeley, CA 94720 USA ([email protected]) Masahiro Shimotani Faculty of Economics Fukui Prefectural University Fukui City, Japan ([email protected]) 1 INTRODUCTION The title of this volume and the papers that fill it concern business “groups,” a term suggesting an identifiable collection of actors (here, firms) within a clear-cut boundary. The Japanese keiretsu have been described in similar terms, yet compared to business groups in other countries the postwar keiretsu warrant the “group” label least. -
Table A: List of All Commitments/Contributions and Pledges As of 17 February 2010 (Table Ref: R10)
Table A: List of all commitments/contributions and pledges as of 17 February 2010 http://www.reliefweb.int/fts (Table ref: R10) Compiled by OCHA on the basis of information provided by donors and appealing organizations. Donor Channel Description Funding Uncommitted USD Pledges USD 3Com American RC Disaster relief 10,000 0 3M NGOs Working with key humanitarian partners like 1,000,000 0 Project HOPE and MAP International, 3M has donated numerous boxes and cases containing medical supplies such as Nexcare bandages, 3M Tegaderm transparent dressings, sterile drapes, splints, medical tapes and respiratory protection products. 3M continues to work closely with its nonprofit partners to identify other 3M products that may be needed. Abbott Laboratories UN Agencies, In-kind: Donations of medicines and nutritional 1,000,000 0 NGOs and Red products Cross ACE Charitable Foundation American RC Humanitarian assistance 250,000 0 Actavis Group NGOs Donation from Actavis in the US to Americares 10,000 0 and Operation Smile for health response in Haiti. Actavis Group NGOs; Red Donation of generic drugs, including analgesics 2,100,840 0 Cross and antibiotics. Advent Software PIH Humanitarian assistance 0 25,000 Adventist Development ADRA-Haiti Emergency assistance 0 478,000 and Relief Agency Adventist Development ADRA-Haiti Emergency assistance 0 522,000 and Relief Agency Aetna Foundation MSF Haiti relief efforts 10,000 0 Aetna Foundation American RC Haiti relief efforts 10,000 0 Aetna Foundation Food for the Haiti relief efforts 10,000 0 Poor Aetna Foundation UM For medical missions to Port-au-Prince, 10,000 0 including neurosurgeons, orthopedic surgeons and trauma/emergency physicians. -
Integrated Report 2016 Year Ended March 31, 2016 Strengths That Increase Supporting Sustainable Creating Long-Term Value Our Value to Society Manufacturing Processes
Integrated Report 2016 Year ended March 31, 2016 Strengths that increase Supporting sustainable Creating long-term value our value to society manufacturing processes The Company Policy of Shionogi Contents Strengths that increase our value to society The Company Policy of Shionogi (Established in 1957) Creating long-term value Supporting sustainable manufacturing processes Data Section Editorial Policy This Integrated Report provides a wide range of information to give shareholders, Forward-looking Statements investors and other stakeholders a deeper understanding of the Shionogi Group’s This report contains forward-looking statements. These statements are based on corporate value. In addition to financial data, readers can access information expectations in light of the information currently available, assumptions that are about management strategy and the Group’s governance, social and environmen- subject to risks, and uncertainties which could cause actual results to differ tal activities. materially from these statements. Risks and uncertainties include general domestic and international economic Period Under Review conditions, such as general industry and market conditions, and changes of Fiscal 2015 (April 1, 2015–March 31, 2016) interest rates and currency exchange rates. Certain activities continuing after fiscal 2015 are also included. These risks and uncertainties particularly apply to forward-looking statements concerning existing products and those under development. Product risks and Scope and Organization uncertainties include, but are not limited to, completion and discontinuation of This Integrated Report encompasses the activities of Shionogi & Co., Ltd. and 37 clinical trials; obtaining regulatory approvals; claims and concerns about product consolidated subsidiaries. safety and efficacy; technological advances; adverse outcome of important In this report, “Shionogi” refers to Shionogi & Co., Ltd. -
Facilitation of Information Transfer on Chemicals in Products
Facilitation of Information Transfer on Chemicals in Products The Ministry of Economy, Trade and Industry (METI) developed ‘chemSHERPA’ [kémʃéərpə] as a new information transfer scheme for chemicals in products throughout their supply chains. METI hopes that the dissemination of chemSHERPA may contribute to reduce the workload of both providers and recipients of the information. From the beginning of the development of chemSHERPA, METI has been in communication with international bodies such as the IEC and the IPC, etc., with the aim of developing chemSHERPA into not only a Japanese standard but also an International standard. To make it a de-facto standard, METI has introduced this scheme to international organizations and governments of other countries for their active use. The Joint Article Management Promotion Consortium (JAMP) is a governing body for chemSHERPA from April 2016 and see a shift to chemSHERPA. We believe many companies are preparing towards implementing chemSHERPA. Based on the efforts mentioned above, the following companies and company groups have agreed with the dissemination of chemSHERPA, and METI will continue to work with JAMP and companies to spread the use of chemSHERPA to internal as well as external supply chains as needed.(Please contact us if any company or company group has interest in putting its name below.) It should be noted, the use of the provision of data entry support tools is free of charge in principle with the aim of promoting wider use of chemSHERPA. [Contact information] Chemical Management Policy Division Manufacturing Industries Bureau Ministry of Economy, Trade and Industry [email protected] 03-3501-0080 (direct) 03-3501-1511 (ex. -
Translation for Reference Only Ticker Code: 4507 to All Shareholders June 5, 2018
Translation for reference only Ticker Code: 4507 To All Shareholders June 5, 2018 Notice of Convocation of the 153rd Annual General Meeting of Shareholders The 153rd Annual General Meeting of Shareholders will be convened at the time and location listed below. On behalf of the directors of the Company, we cordially invite you to attend this shareholders’ meeting. If you are unable to attend, you can exercise your voting rights with the proxy form on the back of this notice. If you wish to vote by using the proxy form, you are kindly requested to take the time to review the reference information provided below and exercise it by 5:00 p.m., Tuesday June 19, 2018.1 Yours faithfully, Isao Teshirogi Representative director and president and CEO Shionogi & Co., Ltd. 1-8, Doshomachi 3-chome, Chuo-ku, Osaka 541-0045, Japan Annual General Meeting of Shareholders 1. Date and time: 10:00 a.m., Wednesday, June 20, 2018 2. Location: HERBIS HALL 5-25, Umeda 2-chome, Kita-ku, Osaka 530-0001, Japan 3. Agenda: Items to report: 1. The Business Report, the Consolidated Financial Statements and the Non-Consolidated Financial Statements for the 153rd Fiscal Term (year ended March 31, 2018) 2. The Audit Report of the Consolidated Financial Statements for the 153rd Fiscal Term (year ended March 31, 2018) by the Accounting Auditor and the Board of Corporate Auditors Items for resolution: Proposal No. 1: Appropriation of Surplus Proposal No. 2: Amendments to the Articles of Incorporation Proposal No. 3: Election of Six (6) Directors Proposal No. -
BMS Interface for Air-Conditioning Systems
BMS Interface for Air-Conditioning Systems Installation and User Guide www.microtrol.co.uk BACnetTM is a registered trademark of ASHRAE (American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc.) Contents 1. Supplied Parts............................................................................................................................ 3 2. Important Information ............................................................................................................... 4 3. Product Overview ...................................................................................................................... 5 3.1 Differences between Black Pear 1 and Black Pear 2 ......................................................................... 6 4. Connection Details .................................................................................................................... 7 4.1 Power Supply ....................................................................................................................................... 7 4.2 HVAC Communications Network ........................................................................................................ 7 4.3 Serial Communication Port .................................................................................................................. 8 4.4 Digital Input / Output ............................................................................................................................ 8 4.5 USB ..................................................................................................................................................... -
Carving out Daikin's Future with AI And
A Science Dream Created by People Vol.03 Technology and May.2018 Innova tion Center Special Feature Daikin Undergoes Transformation Carving out Daikin’s Future with AI and IoT Interview Yoichi Ochiai The digital nature society that is just around the corner. TIC seeks collaborative partners with whom to generate new value. How should the future For further inquiries, please contact: [email protected] look for technology? Date of publication: May 1, 2018 (Volume 03) Published by Technology and Innovation Center, Daikin Industries, Ltd. 1-1, Nishi-Hitotsuya, Settsu, Osaka 566-8585, Japan (within Yodogawa Plant) http://www.daikin.com/about/corporate/tic/index.html Phone. +81-6-6195-7051 (switchboard) Y Interview oichi Daikin Undergoes Transformation Contents……22 Group Leader and Senior Engineer Technology and Innovation Center IAQ Technology Defining the Researcher ③ Tomohiro Yabu Conventional air conditioners will become ……26 Vol. 03 systems that maintain temperature while 2018 stimulating the senses Key Technology ③ “Advancement” ……30 of analysis/evaluation technology ……33 O A Science Dream Created by People ……01 Introducing future of air conditioner Daikin thinks of Technology and Innovation Center Heating, Ventilating, Vol.03 Head of the Digital Nature Group, May.2018 A Science Dream Created by People University of Tsukuba Air-conditioning and Refrigerating Technologyion Centerand CarvingSpecial Article out Daikin’s Future with AI and IoT Innova t Daikin Undergoes Transformation Expo Report Special Feature Interview Carving out Recent External Presentations Daikin’s Future Yoichi Ochiai ……04 with AI and IoT Yoichi Ochiai Challenge Interview The digital nature society The digital nature society that is just around the corner. -
Coolplug Coolinkhub HVAC Bridge Quick Installation Guide
CoolPlug CooLinkHub HVAC Bridge Quick Installation Guide Warning Read and understand the following Safety Guidelines and Warnings to ensure a safe installation Failure to follow WARNING may result in injury or death. This equipment is to be installed by accredited Install the equipment only in a restricted access electrician or similar technical personnel, as per location. these installation instructions. When wall mounting, be sure to fix firmly on a stable Read the installation instructions before connecting surface and in accordance to the instructions below. the system to the power source. When DIN rail mount fix the devices properly to All electrical work must be performed by a licensed the DIN rail following the instructions below. technician, according to local regulations. When mounting on DIN rail inside a metallic cabinet Ultimate disposal of this product should be handled be sure to properly connected to earth. according to all national laws and regulations. Unplug power when connecting the wires. Installation of the equipment must comply with local Pay attention to the polarity of power and and national electrical legislation for installation of communication cables when connecting them electric equipment. Disconnect power of any bus or communication Do not install the devices outdoors or exposed to cable before connecting the system direct solar radiation, water, high relative humidity or dust. 3 Caution Failure to follow CAUTION may result in serious injury, DO NOT INSTALL COOLINKHUB or COOLPLUG property damage or in some circumstances, even IN THE FOLLOWING LOCATIONS: death. a) Where mineral oil mist or oil spray or vapor is Do not allow children to play with the CoolPlug or produced, for example, in a kitchen.