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Abbott Labora Tories Zambon Actelion Wockhardt Ajinomoto W a Tson Pharmaceuticals Alexion Pharmaceuticals W Arner Chilcott Aller

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Abbott Labora Tories Zambon Actelion Wockhardt Ajinomoto W a Tson Pharmaceuticals Alexion Pharmaceuticals W Arner Chilcott Aller ZAMBON ABBOTT LABORATORIES WOCKHARDT ACTELION WATSON PHARMACEUTICALS AJINOMOTO WARNER CHILCOTT ALEXION PHARMACEUTICALS VERTEX PHARMACEUTICALS ALLERGAN VALEANT PHARMACEUTICALS ALMIRALL UNITED THERAPEUTICS AMGEN UCB AMYLIN PHARMACEUTICALS TORAY INDUSTRIES ASAHI KASEI TEVA ASPEN PHARMACARE TEIJIN ASTELLAS TAKEDA ASTRAZENECA TAISHO PHARMACEUTICAL BAXTER INTERNATIONAL SUN PHARMACEUTICAL INDUSTRIES BAYER STADA BIOGEN IDEC SIGMA-TAU BOEHRINGER INGELHEIM SHIRE BRISTOL-MYERS SQUIBB SHIONOGI CADILA SERVIER CELGENE SAWAI PHARMACEUTICAL CHIESI SANTEN CIPLA SANOFI COVIDIEN ROCHE CSL RECORDATI CUBIST PHARMACEUTICALS PIERRE FABRE DAIICHI SANKYO PHARMSTANDARD DAINIPPON SUMITOMO PFIZER DONG-A PAR PHARMACEUTICAL COMPANIES dr reddy’s OTSUKA HOLDINGS EISAI ORION PHARMA ELAN ONO PHARMACEUTICAL ENDO PHARMACEUTICALS NOVO NORDISK ESTEVE NOVARTIS FERRING NIPPON SHINYAKU FOREST LABORATORIES MYLAN GALDERMA MOCHIDA GALENICA AG MITSUBISHI TANABE GEDEON RICHTER 100 MERZ GILEAD SCIENCES MERCK KGAA GLAXOSMITHKLINE MERCK & CO GREEN CROSS MENARINI GRUENENTHAL MEIJI HOLDINGS HISAMITSU MEDICIS PHARMACEUTICAL HOSPIRA MEDA IPSEN MARUHO JAPAN TOBACCO LUPIN JOHNSON & JOHNSON LUNDBECK KAKEN PHARMACEUTICAL LILLY KISSEI LEO PHARMA KRKA KYOWA HAKKO KIRIN KYORIN HOLDINGS Pharma&Biotech Looking for an Easier Way? Bridge the Gap with Lonza’s Easy Access Services for ADCs Lonza offers early development and manufacturing services for your antibody-drug conjugates (ADCs). Take advantage of the best characteristics of monoclonal antibodies (mAbs) and the potency of cytotoxic molecules with Lonza’s early access ADC programs. – Preparation of ADC sample panels using a variety of linker, drug, and mAb combinations – R&D safety labs for process development and/or toxic batches (5mg–40g) – GMP suites for clinical supply (50–150g) – Complete analytical development packages with mAb/ADC harmonization – Quick turnaround of R&D projects, toxicology batches and Phase I GMP production – Dedicated staff and over 60 GMP clinical ADC batches released with very high success rates – Production capacity for all your early stage, late stage and full commercial needs Order your ADC sample preparation at www.lonza.com/adc [email protected] North America + 1 201 316 9200, Europe +41 61 316 9200 www.lonza.com SCRIP 100.COM Contents How to feed your giant SCRIP 100 5 BUSINESS 10 Since 2009, the pharma industry has C-SUITE 17 cut almost 150,000 jobs in the US alone. If news of layoffs were not LEADERSHIP 24 uncomfortable enough, the challenges facing this industry – which have CAREERS 31 never been so present nor acute – make the cuts even more painful and R&D 38 even more necessary. At a time when the pharma giant CLINICAL TRIALS 48 confronts its greatest tests head on (data disclosure, an anachronistic THE PATIENT 59 business model, patent expiries, and reimbursement to name a few), will the EMERGING MARKETS 65 limbs that have survived amputation be strong enough to drag the weighty POLICY & REGULATION 75 torso of the injured behemoth over the Our front cover image shows the top 100 modern healthcare horizon? MARKET ACCESS 83 pharma companies, ranked by total 2011 Of course, it is down to those that pharmaceutical sales, and in alphabetical have survived the lopping of limbs to MANUFACTURING 89 order. The companies with more sales have save the day, coming to the rescue of a longer line. Designed by Emily Foster. both themselves and the bruised FUTUROLOGY 96 colossus. The message to this group of people is clear: now is the time to provide the muscle, now is the time to SCRIP 100 EDITOR INDIA EDITOR CONTRIBUTORS SCRIP HEAD OFFICE Joanne Payne Anju Ghangurde John Bird Informa Pharma, be your own hero. Pharma has never Dr Christine Blazynski 119 Farringdon Road, CHIEF CONTENT WASHINGTON EDITOR been more in need of good ideas – Neena Brizmohun London EC1R 3DA OFFICER, DATAMONITOR Donna Young Dr Peter Charlish Tel: +44 (0)20 7017 5000 intellectual nutrition to bolster its HEALTHCARE Tracy DeGregorio US WEST COAST EDITOR Fax: +44 (0)20 7017 6965 Mike Ward Duncan Emerton waning health – and it is the strongest Mandy Jackson Wang Fangqing US OFFICE CHIEF OF CONTENT, leaders that will find the heroes to Ben Goldacre 52 Vanderbilt Avenue, SCRIP GROUP SENIOR REPORTER George Green 7th Floor, provide this life-saving elixir. Christopher Bowe Francesca Bruce Michael Hay New York In the meantime, the lost limbs of MANAGING EDITOR EDITORIAL ASSISTANT Maura Musciacco NY10017, US the immobile giant have scuttled off, John Hodgson Gemma Sharman Josh Owide Tel: +1 212 972 4899 Ian Schofield Fax: +1 212 972 4855 EDITORIAL INTERN often morphing into innovators that HEAD OF DATA & Andy Smith Lucie Ellis Japan OFFICE may yet herald the salvation of the RESEARCH Ashley Yeo Alex Shimmings T Hirata, Shiryo Kenkyujo DESIGNER healthcare industry, and return to feed SUBSCRIPTIONS Co Ltd Emily Foster 3-5-20-405 Sotokanda, the giant on their own terms. ASIA EDITOR Tel: +(0)800 012 8020 Ian Haydock Chiyoda-ku Tokyo PUBLISHING DIRECTOR Fax: +44 (0)20 7017 6985 101-0021, Japan However, it may yet be those Phil Jarvis [email protected] EMEA EDITOR Tel: +81 3 3258 9207 survivors that nourish the staggering Eleanor Malone ADVertising Subscription rates Fax: +81 3 3258 9209 goliath and that navigate new NEWS EDITOR Rakesh Chauhan UK £2,630; Europe €3,900 pathways, that create a future – and a Dr Sukaina Virji James Kenney US/Canada US$5,090 Neil Hartley giant – worth saving. All articles published are the copyright of Informa Healthcare, a trading division of Informa Group plc, and should not be reproduced or copied in whole or in part without the written permission of the publisher. Every effort has been made to ensure the contents of this publication are factually correct but neither the authors nor the publisher accepts liability for injury, damages or losses arising from the material published in this journal. All images courtesy of shutterstock.com unless otherwise stated. Joanne Payne, Editor Printed by Wyndeham Grange, Southwick ISSN 2042-9622 © Informa UK Ltd 2012 FORMERLY EURAND PHARMACEUTICAL TECHNOLOGIES Proprietary technologies for differentiated oral products CUSTOMIZED BIOAVAILABILITY TASTE MASKING DRUG RELEASE ENHANCEMENT AND ODTs Aptalis Pharmaceutical Technologies develops and manufactures enhanced pharmaceutical products using its broad range of proprietary oral pharmaceutical technologies. Visit us at www.AptalisPharmaceuticalTechnologies.com to view our current product portfolio available for out-licensing and learn more about our full service co-development capabilities using our technologies. F01 Scrip100 Print Ad 208X273mm.indd 1 11/2/12 10:49 AM SCRIP 100 Pharma slims down to retain healthy heart John Bird Lead Analyst, This year’s Scrip 100 company rankings, based on total 2011 pharmaceutical Datamonitor sales, reveal a story of an industry still trying to evolve into a more modern Healthcare beast. John Bird takes a closer look. Total pharmaceutial sales of the Scrip highest-placed pharma company in decline by $600 million in the final 100 league table members in 2011 2011, French firm Sanofi. These top quarter of 2011 (a significant amount equaled $687 billion, with the leading two players had contrasting years, given generics were only available in the 100 prescription pharmaceutical Pfizer posted a year-on-year sales US for roughly half of that quarter). In companies’ total increasing by 7.8% decline of 1.3%, whereas Sanofi total, sales of Lipitor declined by over over 2010’s figure of $637 billion, or (boosted by consolidating sales of 10% during 2011, versus its 2010 figure. $50 billion in absolute terms. Genzyme following the completion of However, it is not just the leading the acquisition of the US biotech in statin’s sales declines that Pfizer has to EXPIRIES HAVE FINAL WORD April, 2011) ramped up its topline by contend with. Pfizer faces the problems On top of the Scrip 100 table for 2011, 15.2% over its 2010 total. of a maturing portfolio with an extensive with sales of almost $58 billion, is once In the final quarter of 2011, Pfizer’s array of high sales generating-drugs again the US pharma giant Pfizer. The long standing flagship product, the that are experiencing, or are soon to New York-based firm still commands a anti-dyslipidemia therapeutic Lipitor experience, generic sales erosion. dominant position, with its 2011 total (atorvastatin) lost patent protection in In total, over $12 billion in sales are (from prescription pharmaceuticals) a its key US market and with the ensuing expected to be wiped from Pfizer’s clear $11 billion ahead of the second generic sales entry saw its global sales topline over the period 2011-17 which SCRIP100.COM SCRIP 100 5 SCRIP 100 By 2017, equates to over 20% of the company’s therapy for chronic myeloid leukemia DOMESTIC BRIC companies NOT Datamonitor total sales in 2011. Lipitor is responsible Gleevec/Glivec (imatinib) and its QUITE THERE YET expects Novartis for over $7 billion of this expiry successful 2011 launch of MS drug In terms of the emerging markets, it is to be the biggest portfolio decline, with other significant Gilenya (fingolimod), along with the India that dominates with six companies industry player declines expected to come from continued uptake of the cancer therapy inside the Scrip 100 list (the third Celebrex (celecoxib), Geodon/Zeldox Afinitor (everolimus) will position the highest total for an individual country). (ziprasidone) and Zyvox (linezolid). company as the best performing of the Surprisingly, Chinese pharmaceutical Such is the maturity of Pfizer’s pharma companies with sales in excess firms are absent from the top 100. In offering, Datamonitor has identified 40 of $10 billion. fact, the largest firm from the world’s key brands that are positioned within By 2017, Datamonitor expects highest populated country was in 129th Pfizer’s portfolio that are currently Novartis (including sales from its generic place, the China Pharmaceutical Group, facing generic sales erosion, or will in business unit Sandoz) to be the biggest with 2011 prescription pharma sales the near future.
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