October 26, 2010 u vol. 107 u no. 43 u 18233–18742

Cover image: Pictured is a reef shark on the Great Barrier Reef. Laurence J. McCook et al. provide data to demonstrate that, although some marine species remain significantly de- pleted, reef shark, fish, corals, and other populations on the Great Barrier Reef may benefit when marine reserves are integrated into large-scale, adaptively managed networks. See the article by McCook et al. on pages 18278–18285, which is part of the Marine Reserves Special Feature. Image courtesy of Laurence J. McCook. From the Cover

18278 Networking marine resources 18487 Adaptive genome shuffling 18533 Birds and bioenergy landscapes 18545 Predicting cancer cell evolution

Contents COMMENTARIES 18235 Does horizontal mixing explain phytoplankton dynamics? THIS WEEK IN PNAS Raphael M. Kudela See companion article on page 18366

18233 In This Issue 18237 Livestock production and the global environment: Consume less or produce better? Henning Steinfeld and Pierre Gerber See companion article on page 18371 LETTERS (ONLINE ONLY) 18239 The tryptophan photoproduct 6-formylindolo[3,2-b] carbazole helps genes jump E161 Chronic fatigue syndrome: Xenotropic murine leukemia Agneta Rannug virus-related virus, murine leukemia virus, both, See companion article on page 18487 or neither? 18241 Population genetics meets cancer genomics Otto Erlwein, Steve Kaye, Mark Robinson, Roland R. Regoes and Myra McClure See companion article on page 18545

E162 Possible widespread low-level occurrence of murine leukemia virus-related gene INAUGURAL ARTICLE sequences in humans W. John Martin 18243 Mental models and human reasoning E163 Reply to Erlwein et al. and Martin: On detection of Philip N. Johnson-Laird murine leukemia virus-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors Shyh-Ching Lo, Natalia Pripuzova, Bingjie Li, Anthony L. MARINE RESERVES SPECIAL FEATURE Komaroff, Guo-Chiuan Hung, Richard Wang, and Harvey J. Alter INTRODUCTION 18251 Evolving science of marine reserves: New developments and emerging research frontiers Steven D. Gaines, Sarah E. Lester, Kirsten Grorud-Colvert, Free online through the PNAS open access option. Christopher Costello, and Richard Pollnac

PNAS u October 26, 2010 u vol. 107 u no. 43 u iii–viii Downloaded by guest on September 24, 2021 PERSPECTIVES APPLIED PHYSICAL SCIENCES 18278 Adaptive management of the Great Barrier Reef: 18325 Bankruptcy risk model and empirical tests A globally significant demonstration of the benefits Boris Podobnik, Davor Horvatic, Alexander M. Petersen, of networks of marine reserves Branko Uroševic, and H. Eugene Stanley Laurence J. McCook, Tony Ayling, Mike Cappo, J. Howard Choat, Richard D. Evans, Debora M. De Freitas, Michelle 18331 Kinetics of fiber solidification Heupel, Terry P. Hughes, Geoffrey P. Jones, Bruce Mapstone, C. Mercader, A. Lucas, A. Derré, C. Zakri, Helene Marsh, Morena Mills, Fergus J. Molloy, C. Roland S. Moisan, M. Maugey, and P. Poulin Pitcher, Robert L. Pressey, Garry R. Russ, Stephen Sutton, Hugh Sweatman, Renae Tobin, David R. Wachenfeld, and David H. Williamson CHEMISTRY β 18286 Designing marine reserve networks for both 18336 Structural characterization of a -turn mimic within – conservation and fisheries management a protein protein interface Steven D. Gaines, Crow White, Mark H. Carr, Björn Eckhardt, Wolfgang Grosse, Lars-Oliver Essen, and Stephen R. Palumbi and Armin Geyer 18306 Communicating marine reserve science to diverse audiences ENGINEERING Kirsten Grorud-Colvert, Sarah E. Lester, Satie Airamé, 18342 Large-scale in vivo femtosecond laser neurosurgery Elizabeth Neeley, and Steven D. Gaines screen reveals small-molecule enhancer of regeneration 18318 What lies underneath: Conserving the oceans’ Chrysanthi Samara, Christopher B. Rohde, Cody L. genetic resources Gilleland, Stephanie Norton, Stephen J. Haggarty, Jesús M. Arrieta, Sophie Arnaud-Haond, and Mehmet Fatih Yanik and Carlos M. Duarte 18392 Isolation of circulating tumor cells using a microvortex- generating herringbone-chip RESEARCH ARTICLES Shannon L. Stott, Chia-Hsien Hsu, Dina I. Tsukrov, Min Yu, 18256 Decadal trends in marine reserves reveal differential David T. Miyamoto, Belinda A. Waltman, S. Michael rates of change in direct and indirect effects Rothenberg, Ajay M. Shah, Malgorzata E. Smas, George K. R. C. Babcock, N. T. Shears, A. C. Alcala, N. S. Barrett, Korir, Frederick P. Floyd, Jr., Anna J. Gilman, Jenna B. Lord, G. J. Edgar, K. D. Lafferty, T. R. McClanahan, and G. R. Russ Daniel Winokur, Simeon Springer, Daniel Irimia, Sunitha Nagrath, Lecia V. Sequist, Richard J. Lee, Kurt J. Isselbacher, 18262 Marine reserves as linked social–ecological systems Shyamala Maheswaran, Daniel A. Haber, and Mehmet Toner Richard Pollnac, Patrick Christie, Joshua E. Cinner, Tracey Dalton, Tim M. Daw, Graham E. Forrester, Nicholas A. J. Graham, and Timothy R. McClanahan ENVIRONMENTAL SCIENCES 18266 Detecting larval export from marine reserves 18348 Regional US carbon sinks from three-dimensional R. A. Pelc, R. R. Warner, S. D. Gaines, and C. B. Paris atmospheric CO2 sampling Cyril Crevoisier, Colm Sweeney, Manuel Gloor, 18272 Incorporating biogeography into evaluations of Jorge L. Sarmiento, and Pieter P. Tans the Channel Islands marine reserve network Scott L. Hamilton, Jennifer E. Caselle, Dan P. Malone, 18354 Persistence of climate changes due to a range of and Mark H. Carr greenhouse gases Susan Solomon, John S. Daniel, Todd J. Sanford, 18294 The value of spatial information in MPA network design Daniel M. Murphy, Gian-Kasper Plattner, Christopher Costello, Andrew Rassweiler, David Siegel, Reto Knutti, and Pierre Friedlingstein Giulio De Leo, Fiorenza Micheli, and Andrew Rosenberg 18300 Political economy of marine reserves: Understanding 18634 Ecosystem-specific selection pressures revealed the role of opportunity costs through comparative population genomics Martin D. Smith, John Lynham, James N. Sanchirico, Maureen L. Coleman and Sallie W. Chisholm and James A. Wilson

18312 Placing marine protected areas onto the ecosystem- GEOLOGY based management seascape Benjamin S. Halpern, Sarah E. Lester, and Karen L. McLeod 18360 Biogeographic and evolutionary implications of a diverse paleobiota in amber from the early Eocene of India Jes Rust, Hukam Singh, Rajendra S. Rana, Tom McCann, Lacham Singh, Ken Anderson, Nivedita Sarkar, Paul C. PHYSICAL SCIENCES Nascimbene, Frauke Stebner, Jennifer C. Thomas, Monica Solórzano Kraemer, Christopher J. Williams, Michael S. Engel, Ashok Sahni, and David Grimaldi APPLIED MATHEMATICS 18545 Accumulation of driver and passenger mutations during tumor progression GEOPHYSICS Ivana Bozic, Tibor Antal, Hisashi Ohtsuki, Hannah Carter, 18366 Fluid dynamical niches of phytoplankton types Dewey Kim, Sining Chen, Rachel Karchin, Kenneth W. Francesco d’Ovidio, Silvia De Monte, Séverine Alvain, Kinzler, Bert Vogelstein, and Martin A. Nowak Yves Dandonneau, and Marina Lévy See Commentary on page 18241 See Commentary on page 18235

iv u www.pnas.org Downloaded by guest on September 24, 2021 SUSTAINABILITY SCIENCE ANTHROPOLOGY 18371 Forecasting potential global environmental costs of 18386 Middle Pleistocene lower back and pelvis from an aged livestock production 2000–2050 human individual from the Sima de los Huesos site, Spain Nathan Pelletier and Peter Tyedmers Alejandro Bonmatí, Asier Gómez-Olivencia, Juan-Luis See Commentary on page 18237 Arsuaga, José Miguel Carretero, Ana Gracia, Ignacio Martínez, Carlos Lorenzo, José María Bérmudez de Castro, and Eudald Carbonell

SOCIAL SCIENCES APPLIED BIOLOGICAL SCIENCES 18392 Isolation of circulating tumor cells using a microvortex- ECONOMIC SCIENCES generating herringbone-chip 18294 The value of spatial information in MPA network design Shannon L. Stott, Chia-Hsien Hsu, Dina I. Tsukrov, Min Yu, Christopher Costello, Andrew Rassweiler, David Siegel, David T. Miyamoto, Belinda A. Waltman, S. Michael Giulio De Leo, Fiorenza Micheli, and Andrew Rosenberg Rothenberg, Ajay M. Shah, Malgorzata E. Smas, George K. Korir, Frederick P. Floyd, Jr., Anna J. Gilman, Jenna B. Lord, 18300 Political economy of marine reserves: Understanding Daniel Winokur, Simeon Springer, Daniel Irimia, Sunitha the role of opportunity costs Nagrath, Lecia V. Sequist, Richard J. Lee, Kurt J. Isselbacher, Martin D. Smith, John Lynham, James N. Sanchirico, Shyamala Maheswaran, Daniel A. Haber, and Mehmet Toner and James A. Wilson

18325 Bankruptcy risk model and empirical tests BIOCHEMISTRY Boris Podobnik, Davor Horvatic, Alexander M. Petersen, Branko Uroševic, and H. Eugene Stanley 18398 Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain Ke Liu, Chen Chen, Yahong Guo, Robert Lam, Chuanbing PSYCHOLOGICAL AND COGNITIVE SCIENCES Bian, Chao Xu, Dorothy Y. Zhao, Jing Jin, Farrell MacKenzie, Tony Pawson, and Jinrong Min 18243 Mental models and human reasoning Philip N. Johnson-Laird 18404 Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity P. Andrew Chong, Hong Lin, Jeffrey L. Wrana, SOCIAL SCIENCES and Julie D. Forman-Kay fl 18375 Spontaneous emergence of social in uence in 18410 Mitochondrial Lon protease regulates mitochondrial online systems DNA copy number and transcription by selective Jukka-Pekka Onnela and Felix Reed-Tsochas degradation of mitochondrial transcription factor A (TFAM) SUSTAINABILITY SCIENCE Yuichi Matsushima, Yu-ichi Goto, and Laurie S. Kaguni 18256 Decadal trends in marine reserves reveal differential 18416 Appropriation of the MinD protein-interaction motif by rates of change in direct and indirect effects the dimeric interface of the bacterial cell division R. C. Babcock, N. T. Shears, A. C. Alcala, N. S. Barrett, regulator MinE G. J. Edgar, K. D. Lafferty, T. R. McClanahan, and G. R. Russ Houman Ghasriani, Thierry Ducat, Chris T. Hart, Fatima Hafizi, Nina Chang, Ali Al-Baldawi, Saud H. Ayed, Patrik 18262 Marine reserves as linked social–ecological systems Lundström, Jo-Anne R. Dillon, and Natalie K. Goto Richard Pollnac, Patrick Christie, Joshua E. Cinner, Tracey Dalton, Tim M. Daw, Graham E. Forrester, Nicholas A. J. 18422 Structure and mechanism of the complex between Graham, and Timothy R. McClanahan cytochrome P4503A4 and ritonavir Irina F. Sevrioukova and Thomas L. Poulos 18300 Political economy of marine reserves: Understanding 18428 Structural insight into the mechanisms of enveloped the role of opportunity costs virus tethering by tetherin Martin D. Smith, John Lynham, James N. Sanchirico, Haitao Yang, Jimin Wang, Xiaofei Jia, Matthew W. McNatt, and James A. Wilson Trinity Zang, Baocheng Pan, Wuyi Meng, Hong-Wei Wang, 18371 Forecasting potential global environmental costs of Paul D. Bieniasz, and Yong Xiong – livestock production 2000 2050 18433 Dimerization of a viral SET protein endows its function Nathan Pelletier and Peter Tyedmers Hua Wei and Ming-Ming Zhou See Commentary on page 18237 18439 ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis Yusuke Ohno, Shota Suto, Masao Yamanaka, Yukiko BIOLOGICAL SCIENCES Mizutani, Susumu Mitsutake, Yasuyuki Igarashi, Takayuki Sassa, and Akio Kihara

AGRICULTURAL SCIENCES 18381 Plasma membrane-localized transporter for BIOPHYSICS AND COMPUTATIONAL BIOLOGY aluminum in rice 18445 Probability landscape of heritable and robust epigenetic Jixing Xia, Naoki Yamaji, Tomonari Kasai, state of lysogeny in phage lambda and Jian Feng Ma Youfang Cao, Hsiao-Mei Lu, and Jie Liang

PNAS u October 26, 2010 u vol. 107 u no. 43 u v Downloaded by guest on September 24, 2021 18451 Unfolding free energy of a two-domain transmembrane ECOLOGY sugar transport protein 18256 Decadal trends in marine reserves reveal differential Heather E. Findlay, Nicholas G. Rutherford, rates of change in direct and indirect effects Peter J. F. Henderson, and Paula J. Booth R. C. Babcock, N. T. Shears, A. C. Alcala, N. S. Barrett, 18457 Crowding and hydrodynamic interactions likely G. J. Edgar, K. D. Lafferty, T. R. McClanahan, and G. R. Russ dominate in vivo macromolecular motion 18366 Fluid dynamical niches of phytoplankton types Tadashi Ando and Jeffrey Skolnick Francesco d’Ovidio, Silvia De Monte, Séverine Alvain, 18463 Role of the synaptobrevin C terminus in fusion Yves Dandonneau, and Marina Lévy pore formation See Commentary on page 18235 Annita N. Ngatchou, Kassandra Kisler, Qinghua Fang, 18523 Invasive honeysuckle eradication reduces tick-borne Alexander M. Walter, Ying Zhao, Dieter Bruns, disease risk by altering host dynamics Jakob B. Sørensen, and Manfred Lindau Brian F. Allan, Humberto P. Dutra, Lisa S. Goessling, 18469 Initiation of the proton pump of cytochrome c oxidase Kirk Barnett, Jonathan M. Chase, Robert J. Marquis, Ilya Belevich, Elena Gorbikova, Nikolai P. Belevich, Virve Genevieve Pang, Gregory A. Storch, Robert E. Thach, Rauhamäki, Mårten Wikström, and Michael I. Verkhovsky and John L. Orrock 18528 Ecological convergence in a rocky intertidal shore CELL BIOLOGY metacommunity despite high spatial variability 18475 A chromatin localization screen reveals poly(ADP ribose)- in recruitment regimes regulated recruitment of the repressive polycomb Andrés U. Caro, Sergio A. Navarrete, and NuRD complexes to sites of DNA damage and Juan Carlos Castilla Danny M. Chou, Britt Adamson, Noah E. Dephoure, Xu Tan, Amanda C. Nottke, Kristen E. Hurov, Steven P. Gygi, ENVIRONMENTAL SCIENCES Monica P. Colaiácovo, and Stephen J. Elledge 18533 Bird communities in future bioenergy landscapes of the 18481 Constitutively active calcineurin induces cardiac Upper Midwest endoplasmic reticulum stress and protects against Timothy D. Meehan, Allen H. Hurlbert, and Claudio Gratton apoptosis that is mediated by α-crystallin-B Nicolas Bousette, Shaan Chugh, Vincent Fong, Ruth Isserlin, EVOLUTION Kyoung-Han Kim, Allen Volchuk, Peter H. Backx, Peter Liu, 18360 Biogeographic and evolutionary implications of a diverse Thomas Kislinger, David H. MacLennan, Andrew Emili, paleobiota in amber from the early Eocene of India and Anthony O. Gramolini Jes Rust, Hukam Singh, Rajendra S. Rana, Tom McCann, 18487 Induction of long interspersed nucleotide element-1 (L1) Lacham Singh, Ken Anderson, Nivedita Sarkar, Paul C. retrotransposition by 6-formylindolo[3,2-b]carbazole Nascimbene, Frauke Stebner, Jennifer C. Thomas, (FICZ), a tryptophan photoproduct Monica Solórzano Kraemer, Christopher J. Williams, Noriyuki Okudaira, Kenta Iijima, Takayoshi Koyama, Michael S. Engel, Ashok Sahni, and David Grimaldi Yuzuru Minemoto, Shigeyuki Kano, Akio Mimori, 18539 Nematogalectin, a nematocyst protein with GlyXY and and Yukihito Ishizaka galectin domains, demonstrates nematocyte-specific See Commentary on page 18239 alternative splicing in Hydra 18493 Pheochromocytoma in rats with multiple endocrine Jung Shan Hwang, Yasuharu Takaku, Tsuyoshi Momose, neoplasia (MENX) shares gene expression patterns Patrizia Adamczyk, Suat Özbek, Kazuho Ikeo, Konstantin with human pheochromocytoma Khalturin, Georg Hemmrich, Thomas C. G. Bosch, Sara Molatore, Sandya Liyanarachchi, Martin Irmler, Thomas W. Holstein, Charles N. David, Aurel Perren, Massimo Mannelli, Tonino Ercolino, Felix and Takashi Gojobori Beuschlein, Barbara Jarzab, Jan Wloch, Jacek Ziaja, Saida Zoubaa, Frauke Neff, Johannes Beckers, Heinz Höfler, GENETICS Michael J. Atkinson, and Natalia S. Pellegata 18545 Accumulation of driver and passenger mutations during 18499 The zebrafish foxj1a transcription factor regulates cilia tumor progression function in response to injury and epithelial stretch Ivana Bozic, Tibor Antal, Hisashi Ohtsuki, Hannah Carter, Nathan E. Hellman, Yan Liu, Erin Merkel, Christina Austin, Dewey Kim, Sining Chen, Rachel Karchin, Kenneth W. Stephanie Le Corre, David R. Beier, Zhaoxia Sun, Neeraj Kinzler, Bert Vogelstein, and Martin A. Nowak Sharma, Bradley K. Yoder, and Iain A. Drummond See Commentary on page 18241 18505 Coordination of IL-7 receptor and T-cell receptor 18551 Adaptation to diverse nitrogen-limited environments signaling by cell-division cycle 42 in T-cell homeostasis by deletion or extrachromosomal element formation Fukun Guo, David Hildeman, Pulak Tripathi, of the GAP1 locus Chinavenmeni S. Velu, H. Leighton Grimes, and Yi Zheng David Gresham, Renata Usaite, Susanne Manuela Germann, Michael Lisby, David Botstein, and Birgitte Regenberg 18511 p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation 18557 SET DOMAIN GROUP2 is the major histone H3 lysie 4 Ruth Scherz-Shouval, Hilla Weidberg, Chagay Gonen, trimethyltransferase in Arabidopsis Sylvia Wilder, Zvulun Elazar, and Moshe Oren Lin Guo, Yanchun Yu, Julie A. Law, and Xiaoyu Zhang 18517 ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of IMMUNOLOGY migrating cells 18563 Syk is a dual-specificity kinase that self-regulates the Kossay Zaoui, Khedidja Benseddik, Pascale Daou, signal output from the B-cell antigen receptor Danièle Salaün, and Ali Badache Beate Heizmann, Michael Reth, and Simona Infantino

vi u www.pnas.org Downloaded by guest on September 24, 2021 18569 Neurotoxic lupus autoantibodies alter brain function 18622 p21-activated kinase 4 regulates ovarian cancer cell through two distinct mechanisms proliferation, migration, and invasion and contributes Thomas W. Faust, Eric H. Chang, Czeslawa Kowal, RoseAnn to poor prognosis in patients Berlin, Irina G. Gazaryan, Eva Bertini, Jie Zhang, Jorge Michelle K. Y. Siu, Hoi Yan Chan, Daniel S. H. Kong, Sanchez-Guerrero, Hilda E. Fragoso-Loyo, Bruce T. Volpe, Esther S. Y. Wong, Oscar G. W. Wong, Hextan Y. S. Ngan, Betty Diamond, and Patricio T. Huerta Kar Fai Tam, Hongquan Zhang, Zhilun Li, Queeny K. Y. Chan, Sai Wah Tsao, Staffan Strömblad, 18575 Cell-permeable Foxp3 protein alleviates autoimmune and Annie N. Y. Cheung disease associated with inflammatory bowel disease and allergic airway inflammation 18628 Methionine sulfoxide reductase A down-regulation Je-Min Choi, Jae-Hun Shin, Myung-Hyun Sohn, Martha J. in human breast cancer cells results in a more Harding, Jong-Hyun Park, Zuzana Tobiasova, Da-Young aggressive phenotype Kim, Stephen E. Maher, Wook-Jin Chae, Sung-Ho Park, Antonella De Luca, Fabio Sanna, Michele Sallese, Carmen Chun-Geun Lee, Sang-Kyou Lee, and Alfred L. M. Bothwell Ruggiero, Mauro Grossi, Paolo Sacchetta, Cosmo Rossi, Vincenzo De Laurenzi, Carmine Di Ilio, and Bartolo Favaloro 18581 IL-33 is a crucial amplifier of innate rather than acquired immunity MICROBIOLOGY Keisuke Oboki, Tatsukuni Ohno, Naoki Kajiwara, 18634 Ecosystem-specific selection pressures revealed Ken Arae, Hideaki Morita, Akina Ishii, Aya Nambu, through comparative population genomics Takaya Abe, Hiroshi Kiyonari, Kenji Matsumoto, Maureen L. Coleman and Sallie W. Chisholm Katsuko Sudo, Ko Okumura, Hirohisa Saito, and Susumu Nakae 18640 Development of the malaria parasite in the skin of the mammalian host 18587 Glycosylation of surface Ig creates a functional bridge Pascale Gueirard, Joana Tavares, Sabine Thiberge, Florence between human follicular lymphoma and Bernex, Tomoko Ishino, Genevieve Milon, Blandine Franke– microenvironmental lectins Fayard, Chris J. Janse, Robert Ménard, and Rogerio Amino Vania Coelho, Sergey Krysov, Amir M. Ghaemmaghami, Clostridium thermocellum Mohamed Emara, Kathleen N. Potter, Peter Johnson, 18646 cellulosomal genes are Graham Packham, Luisa Martinez-Pomares, regulated by extracytoplasmic polysaccharides and Freda K. Stevenson via alternative sigma factors Yakir Nataf, Liat Bahari, Hamutal Kahel-Raifer, 18593 Critical role of DNAX accessory molecule-1 (DNAM-1) Ilya Borovok, Raphael Lamed, Edward A. Bayer, in the development of acute graft-versus-host Abraham L. Sonenshein, and Yuval Shoham disease in mice fi Tsukasa Nabekura, Kazuko Shibuya, Eri Takenaka, 18652 Dual selection mechanisms drive ef cient single-gene Hirayasu Kai, Kai Shibata, Yumi Yamashita, Kyoichi reverse genetics for rotavirus Harada, Satoko Tahara-Hanaoka, Shin-ichiro Honda, Shane D. Trask, Zenobia F. Taraporewala, Karl W. Boehme, and Akira Shibuya Terence S. Dermody, and John T. Patton

18599 Two abundant proteasome subtypes that uniquely NEUROSCIENCE process some antigens presented by HLA class I molecules 18243 Mental models and human reasoning Benoît Guillaume, Jacques Chapiro, Vincent Stroobant, Philip N. Johnson-Laird Didier Colau, Benoît Van Holle, Grégory Parvizi, 18342 Large-scale in vivo femtosecond laser neurosurgery Marie-Pierre Bousquet-Dubouch, Ivan Théate, Nicolas screen reveals small-molecule enhancer of regeneration Parmentier, and Benoît J. Van den Eynde Chrysanthi Samara, Christopher B. Rohde, Cody L. Gilleland, Stephanie Norton, Stephen J. Haggarty, MEDICAL SCIENCES and Mehmet Fatih Yanik 18605 Roles and interactions among protease-activated 18658 Kinetics of G-protein–coupled receptor endosomal receptors and P2ry12 in hemostasis and thrombosis trafficking pathways revealed by single quantum dots Ivo Cornelissen, Daniel Palmer, Tovo David, Lisa Wilsbacher, Katye M. Fichter, Marc Flajolet, Paul Greengard, Cherry Concengco, Pamela Conley, Anjali Pandey, and Tania Q. Vu and Shaun R. Coughlin 18664 Light at night increases body mass by shifting the time of food intake 18611 Acceleration of wound healing by growth hormone- releasing hormone and its agonists Laura K. Fonken, Joanna L. Workman, James C. Walton, Zachary M. Weil, John S. Morris, Abraham Haim, Nikolina Dioufa, Andrew V. Schally, Ioulia Chatzistamou, and Randy J. Nelson Evi Moustou, Norman L. Block, Gary K. Owens, Athanasios G. Papavassiliou, and Hippokratis Kiaris 18670 Early deficits in synaptic mitochondria in an Alzheimer’s disease mouse model 18616 Vascular endothelial platelet endothelial cell adhesion Heng Du, Lan Guo, Shiqiang Yan, Alexander A. Sosunov, molecule 1 (PECAM-1) regulates advanced Guy M. McKhann, and Shirley ShiDu Yan metastatic progression

Horace DeLisser, Yong Liu, Pierre-Yves Desprez, Ann Thor, 18676 Direct involvement of σ-1 receptors in the dopamine D1 Paraskevei Briasouli, Chakrapong Handumrongkul, Jonathon receptor-mediated effects of cocaine Wilfong, Garret Yount, Mehdi Nosrati, Sylvia Fong, Gemma Navarro, Estefanía Moreno, Marisol Aymerich, Emma Shtivelman, Melane Fehrenbach, Gaoyuan Cao, Daniel Marcellino, Peter J. McCormick, Josefa Mallol, Dan H. Moore, Shruti Nyack, Denny Liggitt, Antoni Cortés, Vicent Casadó, Enric I. Canela, Jordi Ortiz, Mohammed Kashani-Sabet, and Robert Debs Kjell Fuxe, Carmen Lluís, Sergi Ferré, and Rafael Franco

PNAS u October 26, 2010 u vol. 107 u no. 43 u vii Downloaded by guest on September 24, 2021 18682 Signaling by olfactory receptor neurons near threshold 18735 R gene-controlled host specificity in the Vikas Bhandawat, Johannes Reisert, and King-Wai Yau legume–rhizobia symbiosis Shengming Yang, Fang Tang, Muqiang Gao, 18688 Neurophysiological origin of human brain asymmetry Hari B. Krishnan, and Hongyan Zhu for speech and language Benjamin Morillon, Katia Lehongre, Richard S. J. Frackowiak, Antoine Ducorps, Andreas Kleinschmidt, SUSTAINABILITY SCIENCE David Poeppel, and Anne-Lise Giraud 18266 Detecting larval export from marine reserves 18694 Contribution of calcium-dependent facilitation to R. A. Pelc, R. R. Warner, S. D. Gaines, and C. B. Paris synaptic plasticity revealed by migraine mutations 18272 Incorporating biogeography into evaluations of the in the P/Q-type calcium channel Channel Islands marine reserve network Paul J. Adams, Ravi L. Rungta, Esperanza Garcia, Scott L. Hamilton, Jennifer E. Caselle, Dan P. Malone, Arn M. J. M. van den Maagdenberg, Brian A. MacVicar, and Mark H. Carr and Terrance P. Snutch 18294 The value of spatial information in MPA network design 18700 Ion sensing in the RCK1 domain of BK channels Christopher Costello, Andrew Rassweiler, David Siegel, Guohui Zhang, Sheng-You Huang, Junqiu Yang, Jingyi Shi, Giulio De Leo, Fiorenza Micheli, and Andrew Rosenberg Xiao Yang, Alyssa Moller, Xiaoqin Zou, and Jianmin Cui 18312 Placing marine protected areas onto the ecosystem- 18706 Inhibition of ceramide biosynthesis preserves based management seascape photoreceptor structure and function in a mouse Benjamin S. Halpern, Sarah E. Lester, and Karen L. McLeod model of retinitis pigmentosa Enrica Strettoi, Claudia Gargini, Elena Novelli, Giusy Sala, Ilaria Piano, Paolo Gasco, and Riccardo Ghidoni CORRECTIONS PHYSIOLOGY 18712 β-Adrenergic–regulated phosphorylation of the skeletal APPLIED BIOLOGICAL SCIENCES muscle CaV1.1 channel in the fight-or-flight response Michelle A. Emrick, Martin Sadilek, Keiichi Konoki, 18741 Female-specific flightless phenotype for mosquito and William A. Catterall control Guoliang Fu, Rosemary S. Lees, Derric Nimmo, Diane Aw, 18718 Selectivity of externally facing ion-binding sites in the Li Jin, Pam Gray, Thomas U. Berendonk, Helen White- Na/K pump to alkali metals and organic cations Cooper, Sarah Scaife, Hoang Kim Phuc, Osvaldo Marinotti, Ian M. Ratheal, Gail K. Virgin, Haibo Yu, Benoît Roux, Nijole Jasinskiene, Anthony A. James, and Luke Alphey Craig Gatto, and Pablo Artigas

PLANT BIOLOGY MICROBIOLOGY 18724 Dated molecular phylogenies indicate a Miocene 18741 Lsr2 is a nucleoid-associated protein that targets origin for Arabidopsis thaliana AT-rich sequences and virulence genes in Mark A. Beilstein, Nathalie S. Nagalingum, Mark D. Mycobacterium tuberculosis Clements, Steven R. Manchester, and Sarah Mathews Blair R. G. Gordon, Yifei Li, Linru Wang, Anna Sintsova, Harm van Bakel, Songhai Tian, William Wiley Navarre, 18729 Local DNA hypomethylation activates genes in Bin Xia, and Jun Liu rice endosperm Assaf Zemach, M. Yvonne Kim, Pedro Silva, Jessica A. Rodrigues, Bradley Dotson, Matthew D. Brooks, and Daniel Zilberman ix Subscription Form

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