UC Irvine UC Irvine Previously Published Works Title Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. Permalink https://escholarship.org/uc/item/7n185057 Journal Antioxidants (Basel, Switzerland), 9(4) ISSN 2076-3921 Authors Li, Shiri Takasu, Chie Lau, Hien et al. Publication Date 2020-04-24 DOI 10.3390/antiox9040354 Peer reviewed eScholarship.org Powered by the California Digital Library University of California antioxidants Article Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-nflammatory Pathways Shiri Li 1, Chie Takasu 1 , Hien Lau 1, Lourdes Robles 1, Kelly Vo 1, Ted Farzaneh 2, Nosratola D. Vaziri 3, Michael J. Stamos 1 and Hirohito Ichii 1,* 1 Department of Surgery, University of California, Irvine, CA 92868, USA;
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[email protected] (M.J.S.) 2 Department of Pathology, University of California, Irvine, CA 92868, USA;
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[email protected]; Tel.: +1-714-456-8590; Fax: +1-714-456-8796 Received: 14 March 2020; Accepted: 22 April 2020; Published: 24 April 2020 Abstract: Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium (DSS)-induced colitis via its potential antioxidant capacity, and by inhibiting the activation of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome.