Michael Sean PEPPER, Curriculum Vitae
______
Professional address Room 5-64, Level 5, Pathology Building 15 Bophelo Road (Cnr. Steve Biko and Dr. Savage Streets) Prinshof Campus University of Pretoria Gezina 0002 Pretoria South Africa Tel: +27 (0)12 319 2179 (Secretary) Tel: +27 (0)12 319 2190 (Direct) Fax: +27 (0)12 319 2946 E-mail: [email protected]
EDUCATION
Privat Docent (Habilitation) University of Geneva, Faculty of Medicine, 1997
M.D. University of Geneva, Faculty of Medicine, 1992
Ph.D. University of Geneva, Faculty of Science, 1990
M.B.Ch.B. University of Cape Town Medical School, 1982
REGISTRATION
Health Professionals Council of South Africa (HPCSA) registration no.: MP 0261858 Board of Health Funders practice no.: 0140000207756
PROFESSIONAL APPOINTMENTS
Current
January 2015 - present Director, SAMRC Extramural Unit for Stem Cell Reseaerch and Therapy, Faculty of Health Sciences, University of Pretoria
December 2011 - present Professor, Department of Immunology, Faculty of Health Sciences, University of Pretoria
December 2011 - present Director, Institute for Cellular and Molecular Medicine, University of Pretoria
January 2006 - present Professeur Associé, Department of Human Genetics and Development, Faculty of Medicine, University of Geneva - 2 -
Previous
August 2008-November 2011 Professor, Unit for Advanced Studies, University of Pretoria
January 2005-November 2011 Extraordinary Professor, Department of Immunology, Faculty of Health Sciences, University of Pretoria
January 2007-July 2009 Scientific Director, Netcells Cryogenics (Pty) Ltd
January 2005-July 2008 Managing Director, Netcare Institute of Cellular and Molecular Medicine (Pty) Ltd, Unitas Hospital, Lyttelton, Pretoria
July-December 2004 Professor: Department of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand
January-June 2004 Associate Professor (part-time): Department of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand
June 2003-June 2004 Associate Professor: Department of Morphology, Faculty of Medicine, University of Geneva
Oct 1993-May 2003 Maître d'enseignement et de recherche (Assistant Professor, with tenure): Department of Morphology, Faculty of Medicine, University of Geneva
Jan 1991-Sept 1993 Maître-assistant: Department of Morphology, Faculty of Medicine, University of Geneva
April 1986-Dec 1990 Assistant and Ph.D. student: Department of Morphology, Faculty of Medicine, University of Geneva
1984-March 1986 Department of Clinical Science and Immunology, Faculty of Medicine, University of Cape Town 1984: Post-intern research scholarship; 1985/6: Registrar
1983 Intern: Groote Schuur Hospital, Cape Town
AWARDS AND OTHER RECOGNITION
Exceptional Academic Achiever Award, University of Pretoria, 2015-2017.
Selected for inclusion in the book “Blazing a Biotechnology Trail – Celebrating Biotechnology Excellence in South Africa”. Produced by Public Understanding of Biotechnology (NRF/SAASTA), 2014.
South African MRC Extramural Unit Award: Stem Cell Research and Therapy. 2015-2019.
South African MRC University Flagship Award: Stem Cell Research and Therapy, 2014-2017.
Appointed to the Academy of Science of South Africa, 2013.
- 3 - Finalist, NSTF-BHP Billiton Awards 2013/2014 in the category: Communication for outreach and creating awareness of Science, Engineering, Technology and Innovation.
Finalist, NSTF-BHP Billiton Awards 2012/2013 in the category: Science Communication for Public Awareness over the last 5 years. Sponsored by: The South African Agency for Science and Technology Advancement (SAASTA-NRF).
P. Mabeta and M.S. Pepper: Best overall publication, non-clinical. Faculty of Health Sciences, University of Pretoria, 2009. P. Mabeta and M.S. Pepper: Best overall publication, non-clinical. Faculty of Health Sciences, University of Pretoria, 2011(2012).
“Prix Denber-Pinard” for Privat Docent thesis. University of Geneva, 1997.
Walter J. Johnson Annual Award for post-doctoral research in cell biology. Molecular biology and biochemistry of endothelial cell proteases and their inhibitors. Awarded by Academic Press/Experimental Cell Research, 1994.
“Prix de la Faculté de Médecine” for M.D. thesis in basic medical sciences. University of Geneva, 1992.
South African Medical Research Council Post-Intern Research Scholarship. University of Cape Town, 1984.
SOCIETIES/ASSOCIATIONS
Office bearer
SATiBA – South African Tissue Bank Association (2012-present; Co-founder; President and Charman of the Board: 2015-present) BioSA – Biotechnology SMME Association of South Africa (2007-2008; Co-founder; President: 2008) South African Society for Obesity and Metabolism (2006-2008; Member of the EXCOM) EVBA – European Vascular Biology Association (1993-2004; Treasurer: 1996-2004)
Membership
Genetic Alliance of South Africa (2017-present) South African Transplant Society (2017-present) International Society for Cell and Gene Therapy (2015-present) African Society of Human Genetics (2016-present) Human Genome Organization (2010-present) Southern African Society for Human Genetics (2009-present) World Marrow Donor Association – individual member (2009-present) South African Stem Cell Transplantation Society (2008-present) International AIDS Society (2017-2019) South African Medico-Legal Society (2009-2017) Licensing Executives Society (2008-2011)
COMMITTEES / WORKING GROUPS / SCIENTIFIC BOARD
National Ethical, Legal and Social Implications of Gene Therapy in South Africa – consensus study for the Academy of Science of South Africa. Chairperson (2019-present) South African Stem Cell Transplantation Society (SASCeTS) – Regulatory and accreditation affairs (2019- present) Cell-based Product Task Team, South African Health Products Regulatory Authority (2017-present) - 4 - Ethical, Legal and Social Implications of Genetics and Genomics in South Africa – consensus study for the Academy of Science of South Africa. Chairperson (2015-2018) Co-responsible (with Prof Michele Ramsay) for the Southern African Human Genome Programme (2009-2017) Core Committee, Revision of Chapter 8 of the National Health Act and Human Tissue Regulations (National Department of Health) (2009-2017) Member of the Advisory Committee of the African Center for Gene Technologies (2010-2015) National Public Umbilical Cord Blood Stem Cell Bank Feasibility Study (National Department of Health and South African National Blood Service) (2009-2015) Biobank South Africa Working Group (Co-chair with Prof Ames Dhai) (2014) Bio-economy Strategy (Department of Science and Technology) Health Innovation Strategy implementation panel (2014) Core Planning Group (2010-2011) National Advisory Council on Innovation (Project leader: Bioeconomy policies and strategies) (2012-2014) National Biotechnology Advisory Committee to the Minister of Science and Technology (2006-2012) Chairperson: May-September 2012; Deputy Chair: July 2010-April 2012; Acting Chairperson: October 2009-June 2010
Regional Gauteng Province Biotech Awards, Adjudication Committee (2009)
University of Pretoria Sport, Exercise Medicine and Lifestyle Institute (SEMLI) Advisory Board. (2017-present) Genome Research Institute Management Committee. (2015-present) Research Data Management Committee. (2015-2018)
University of Pretoria Faculty of Health Sciences Research Committee of the School of Medicine. (2013-present) Research Forum Committee. Chairperson. (2012-present) Research Committee of the Faculty of Health Sciences. (2012-present) Comprehensive Physical Rehabilitation Research Centre. Advisory Board. (2008) Faculty Research Plan. Committee member. (2006)
University of Geneva Medical School Scientific board, Institut des sciences du mouvement et de la médecine du sport. (2003) Committee for the evaluation of PhD students salaries. (2003) MD-PhD program. Committee member. (1995-2003) Committee for problem-based teaching program, 2nd and 3rd year medical students. (1999-2002) Committee for the evaluation of teaching. (1996-1997; 2002) Working group: DNA microarrays. (1999) Working group: integration of basic and clinical sciences. (1997)
Network Healthcare Holdings (Netcare) Research Committee. (2005-2008) Bursary Committee. (2007)
BIOTECH/PHARMACEUTICAL CONSULTANT ACTIVITY
Consultant Merck KGaA, Darmstadt, Germany. (2003-2005) Ampath, Pretoria, South Africa. (2004) Modex Therapeutics, Lausanne, Switzerland. (2000-2002) Transgène SA, Strasbourg, France. (1999-2000)
Ad hoc consultant activity Defined Health, Milburn (NJ, USA) Merck KGaA, Darmstadt (Germany) - 5 - Novo Nordisk A/S, Maalov (Denmark) Serono International SA, Geneva (Switzerland) LifeScan Inc., Johannesburg (South Africa)
TRAINING COURSES ATTENDED
Biopsy Techniques Workshop (early embryos - hands-on training), Research Instruments Ltd., Auckland Park, Johannesburg. 7 March 2015.
Southern African Human Genome Programme: Understanding and Characterizing Southern African Genomes. Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg. 28-31 July 2014.
IP Rights from Publicly Funded Research and Developmnent, Center for IP Law, University of Pretoria and Adams and Adams (Pretoria, South Africa). 30 September 2011.
Empowering genomics in southern Africa workshop – Application to infectious diseases.University of Limpopo (Polokwane, South Africa). 30 May – 1 June 2011.
Essential IP Management Short Course. DNAbiotec (Pty) Ltd. The Innovation Hub (Pretoria, South Africa). 12- 13 November 2009.
Introductory Licensing Workshop. Licensing Executives Society. Lynnwood Conference Center (Pretoria, South Africa). 26 November 2008.
Good clinical practice. Wits Health Consortium. (Johannesburg, South Africa). 22 May 2007.
Maximizing Performance. (Johannesburg, South Africa). 2007
EXCO Finance for Non-financila Managers. Netcare Education. (Pretoria, South Africa). 2006. Course organizer: Mr. Graeme Jay.
Swiss 2D PAGE Training Course, Geneva University Hospital (Geneva, Switzerland), 25-29 September 2000. Course organizer: Dr. J.-C. Sanchez.
Cours Romand de Formation à l’Expérimentation Animale, Centre Hospitalier Universitaire Vaudois (Lausanne, Switzerland), 1-5 May 2000. Course organizers: Dr. I. Bolon, Dr. E. Rouiller, Dr. M. Gyger, Dr. T. Pedrazzini.
Immunocytochemistry for Light Microscopy, Royal Postgraduate Medical School, Hammersmith Hospital (London, U.K.), 14-18 January 1985. Course organizer: Dr. J.M. Polak.
Elective in Orthopaedic Surgery, Toronto Western Hospital (Toronto, Canada), 7 November - 18 December 1981. Host: Dr. R.W. Jackson. Sponsorship: the Journal of Bone and Joint Surgery.
LECTURE SERIES / WORKSHOPS / CONFERENCES / SYMPOSIUMS ORGANISED
Research Forum Committee meetings, Faculty of Health Sciences, University of Pretoria Research information sessions (RIS), Postgraduate student/supervisor forums 2012 - present
WHO Expert meeting on Genomics & Genetic disorders. Future Africa, University of Pretoria, South Africa. Co-organized with Dr. M.-C. Boussseau and M. Kajiwara (WHO). 8-11 April 2019 - 6 -
Ethics Workshop, Gender and sexual diversity. Faculty of Health Sciences, University of Pretoria, South Africa. Co-organized with Prof G. Lindeque. 24 March 2018
South African Tissue Bank Association International Conference 2017 Centurion, South Africa Co-organized with Sandra Venter and Cleopatra Ndlovu 5-6 October 2017
Flagship Workshop: Stem Cell Research and Therapy Pretoria, South Africa Co-organized with John Bekker and Thabo Khosa 26-27 October 2017
African Genomic Medicine Training Initiative Continent-wide training programme Working group member, Facilitator and lecturer April-August, 2017
Prostate cancer: at the interface between sexual diversity and clinical management University of Pretoria Prinshof Campus, South Africa 16 March 2017
Swiss-South African Joint Research Program (SSAJRP), Inter-group meeting Kruger National Park, South Africa 8-10 December 2016
Pharmacogenetics and Precision Medicine Conference Collet Dandara (main organizer); co-organizer with Louise Warnich University of Cape Town, South Africa 4-9 April 2016
Swiss-South African Joint Research Program (SSAJRP), Inter-group meeting Royal Elephant Hotel and Conference Center, Centurion, South Africa 22 & 23 October 2015
First International Conference of the South African Tissue Bank Association Co-organizer with Sandra Venter African Pride, Irene Country Lodge, South Africa 18 September 2015
Annual SAMRC University Flagship Workshop Faculty of Health Sciences, University of Pretoria 21 August 2015
Launch of the special SAMRC Flagship edtion of the South African Journal of Bioethics and Law Faculty of Health Sciences, University of Pretoria 20 August 2015
Ethical issues related to the generation of research data including “North-South” interactions Faculty Day, Faculty of Health Sciences, University of Pretoria 19 August 2015
Southern African Human Genome Programme (SAHGP) Ethical, Legal and Social Issues (ELSI) workshop Co-organizer, Prof Himla Soodyall - 7 - Casa Toscana, Pretoria 19 November 2014
MRC University Flagship Award: Stem cell research and therapy University of Pretoria 01 September 2014
Plastic, reconstructive and aesthetic surgery: at the interface between basic and clinical sciences Intervarsity symposium: University of Pretoria, University of the Witwatersrand, MEDUNSA, University of Geneva, Switzerland University of Pretoria 23 June 2014
Swiss-South African Joint Research Program (SSAJRP), Inter-group meeting Biel/Bienne, Switzerland 18 & 19 June 2014
BASAN/UP Inaugural Clean Room Forum University of Pretoria 10 October 2013
Genomics research on indigenous populations: exploring the concept of genomic sovereignty with the San community of southern Africa Kalahari Lodge, Kimberley 10-12 September, 2013
“The Science of Our Times” lecture series Atterbury Theatre, Pretoria 06 August 2013: Stem cells: the hype and the hope 29 October 2013: The human genome 04 February 2014: Sex determination and gender identity
South African Tissue Bank Association (SATiBA) Cascades Guesthouse, Brooklyn, Pretoria: 29 November 2012 SATiBA launch - Blu Raddison, Sandton: 4 May 2012
SAASTA/PUB Critical Thinker’s Forum The Southern African Human Genome Programme, Baxter Theatre, Cape Town, South Africa. 24 November, 2011 Stem Cells, St George’s Hotel & Convention Center, Doornkloof, South Africa. 07 November, 2012
Institute for Cellular and Molecular Medicine Day The Innovation Hub, Pretoria, South Africa 02 November, 2012
Certificate in Bioentrepreneurship (Continuing Education at the University of Pretoria) 21-25 October, 2013 – Pretoria, South Africa 08-12 October, 2012 – Cape Town, South Africa 17-21 September, 2012 – Pretoria, South Africa 16-20 July, 2012 – Durban, South Africa 11-15 June, 2012 – Grahamstown, South Africa 19-23 September, 2011 – Cape Town, South Africa 22-26 August 2011 – Pretoria, South Africa 18-22 October, 2010 – Pretoria, South Africa 28 September-3 October, 2009 – Pretoria, South Africa
Medical Malpractice Litigation Seminar - 8 - Institute for Cellular and Molecular Medicine, University of Pretoria, South Africa. 28 September, 2012 25 August, 2012
Legal aspects relating to the applications of biotechnology College of Law, Unisa, Pretoria, South Africa Co-organizer with Prof. Melodie Slabbert 21 August 2012
Neuroscience Day University of Pretoria, Pretoria, South Africa 10 May 2012 19 May 2011 26 May 2010
Emerging Stem Cell Technologies. Dissecting the complex scientific, ethical and legal landscape Institute for Cellular and Molecular Medicine, University of Pretoria Cricklewood Manor, Pretoria, South Africa 29 September, 2011
Engineering an HIV-resistant Immune System CSIR Conference Center, Pretoria, South Africa Travel grants from the Swiss-South African Joint Research Program for Profs. Karl-Heinz Krause and Roberto Speck - CHF 3 000 (~R 20 000) 10-11 February, 2011
Southern African Human Genome Program Co-organizer with Prof. Michele Ramsay Irene Lodge, Irene, South Africa 27-28 January, 2011
Stem Cell Transplantation Indaba Co-organizer with Drs. Campbell Macfarlane and Carola Nielser Waterfront, Cape Town, South Africa 02-03 August, 2010
Technology Transfer in South Africa Organized in collaboration with the World Bank Institute and SARIMA Cape Town, South Africa 27 November, 2009
The Human Tissue Regulatory Environment The Innovatiopn Hub, Pretoria 27 May, 2009
GoGlobal: Finland. BioSA-COFISA workshops on global opportunities for the South African biotech sector BioSa visit to Finland: 13-15 February 2008 Definitive workshops in SA: 31 March – 03 April 2008 Preliminary workshops in SA: 21-27 February 2008
Bioethics Forum on Stem Cell Banking. Pretoria, South Africa Co-organizer with Adv. Donrich Jordaan 15 June 2007
7th Annual European Conference of Scientists and Plastic surgeons. Geneva, Switzerland Local Scientific Committee 19-20 September, 2003 - 9 -
New Therapeutic Targets in Vascular Biology. Geneva, Switzerland Co-organizer 06-09 February, 2003
International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies Geneva, Switzerland. Organizing committee/Faculty member 8th meeting, 31 January – 02 February, 2002 7th meeting, 25-27 January, 2001 6th meeting, 27-29 January, 2000 5th meeting, 31 January – 02 February, 1999
Co-organizer of the "Journée d'interaction des groupes de recherche des Facultés de médecine de Lausanne et Genève, Changins, Switzerland 4th meeting, 19 October 2000 3rd meeting, 07 October, 1999 2nd meeting, 08 October, 1998 1st meeting, 16 October, 1997
XIth International Vascular Biology Meeting. Geneva, Switzerland Scientific Committee 06-10 September, 2000
Molecular and Cellular Biology of Plasminogen Activation. Les Diablerets, Switzerland Local organizing Committee 04-09 September 1999
Symposium entitled "Positive and negative regulation of angiogenesis: from cell biology to the clinic" at the 29ème Assemblée annuelle de l'Union des Sociétés Suisses de Biologie Expérimentale. Geneva, Switzerland 21 March, 1997
Workshop entitled "Angiogenesis: mechanistic insights and disease" at the 30th Annual Meeting of the European Society for Clinical Investigation. Interlaken, Switzerland Co-organiser with E. Battegay, Basel, Switzerland 25 April, 1996
EXPERT WITNESS
Nel and Nel vs. Steyn, Burger, Springs Private Hospital Group (Pty) Ltd, Zambakides and Stepien. South Gauteng High Court, Johannesburg (Republic of South Africa). Case no. 2004/15546 and 06/17316. 19-23 August, 2010.
- 10 -
CLINICAL WORK
CLINICAL TRAINING
Jan – Dec 1983 Intern: Groote Schuur Hospital, Cape Town General Medicine (4 months), General Surgery (4 months), Emergency Medicine (2 months), Orthopaedic Surgery (2 months)
Jan 1985 – March 1986 Registrar: Groote Schuur Hospital, Cape Town Department of Clinical Science and Immunology
CLINICAL ACTIVITY
Consultant, Gender Reassignment Cinic, Dept Obstetrics and Gynaecology, Steve Biko Academic Hospital. 2013-present.
Permanent consultant, Multidisciplinary consultation for hemangiomas and vascular malformations. Geneva University Hospital. 1994-2004.
Ad hoc consultant, Departments/Divisions of Pediatrics, Dermatology, Surgery (Pediatric, Neuro, Plastic), Radiology and Oncology, Geneva University Hospital. 1990-2004.
REVIEWER ACTIVITIES
RESEARCH GRANT COMMITTEES
Medical Research Council (South Africa)
Research Grants Committee of the Medical Research Council. 2012-2014
National Research Foundation (South Africa)
Human Capacity and Infrastructure Development (HICD) Panel Meeting: Thuthuka applications for 2014 funding and Thuthuka and IRDP annual progress reports. 18 October 2013 Capacity and strategic platforms grants – Health Sciences panel: Thuthuka applications for 2013 funding and Capacity and Strategic Platforms Grants (CSPG) Panel: Sabbatical Programme 2013 Funding. 20 March 2013 Thuthuka and IRDP annual progress reports. 15 November 2012
EDITORIAL BOARDS & EDITORSHIPS
Current Lymphatic Research and Biology (Mary Ann Liebert, Inc). Editorial Board. 2002-present The Journal of Medical Law and Ethics (Paris Legal Publishers). International Editorial Board. 2012-present
Previous Applied and Translational Genomics (Elsevier – discontinued). 2012-2016 Current Angiogenesis (Bentham Science – discontinued). 2011-2015 Arteriosclerosis, Thrombosis & Vascular Biology (American Heart Association). Associate Editor/Editorial Board. 1995-2007 The Angiogenesis Journal (Springer). Editorial Advisory Board. 1997-2007 - 11 - Current Cardiology Reviews (Bentham Science). 2005-2009 The Open General and Internal Medicine Journal (Bentham Open – discontinued). 2007-2010
Editor of Ampath Molecular and Metabolic Medicine Update newsletter 2005: 3 editions 2006: 6 editions 2007: 6 editions 2008: 6 editions 2009: 4 editions
GUEST EDITOR
Applied and Translational Genomics. Special edition on “Pharmacogenomics and Personalized Medicine”. 2012-2013.
ONSITE REVIEWER ACTIVITIES / PANELS
CSIR Biosciences Review Panel, CSIR, Pretoria. 9-11 July, 2014. Panel member.
International Centre for Genetic Engineering and Biotechnology (ICGEB) site visit for the 5 year review of Prof. Iqbal Parker. Cape Town, South Africa. August 14 2012. Panel member.
MRC-NHLS-Wits Human Genomic Diversity and Disease Research Unit (Prof. Himla Soodyall). Johannesburg, South Africa. 27 September 2010. Panel member.
MRC-UCT Human Genetics Research Unit (Prof. Raj Ramesar). Cape Town, South Africa. 22 September 2009. Panel member.
AD HOC REVIEWING
Articles submitted to journals
AIDS Patient Care and STDs, American Journal of Pathology, American Journal of Physiology, Angiogenesis Journal, Applied and Translational Genomics, Arteriosclerosis Thrombosis and Vascular Biology, Biochemical and Biophysical Research Communications, Blood, British Journal of Pharmacology, Cancer Cell, Cancer Journal, Cancer Research, Cell, Cell and Tissue Research, Circulation, Circulation Research, Comparative and International Law Journal of Southern Africa, Current Cardiology Reviews, Current Medicinal Chemistry, Dermatology, Developing World Bioethics, Development, Developmental Biology, EMBO Journal, European Journal of Clinical Investigation, Experimental Cell Research, Experimental Hematology, Expert Opinion On Biological Therapy, FAESB Journal, FEBS Letters, Frontiers in Medicine Gastroenterology, Gene Therapy, International Journal of Cancer, International Wound Journal, Journal of Cell Biology, Journal of Cell Science, Journal of Cellular and Molecular Medicine, Journal of Cellular Physiology, Journal of Clinical Investigation, Journal of Clinical Pathology, Journal of Histochemistry and Cytochemistry, Journal of Investigative Dermatology, Journal of the National Cancer Institute, Journal of Neurosurgery, Laboratory Investigation, Lung Cancer, Microcirculation, Microvascular Research, Molecular and Cellular Biology, Molecular Biology of the Cell, Nature, Nature Medicine, Oncogene, Opthalmologie, PLoS ONE, Proceedings of The National Academy of Sciences USA, Public Health Nutrition, Science, South African Journal of Psychiatry, Stem Cell Reviews and Reports, Stem Cells and Development, The Lancet, Thrombosis and Haemostasis, Tydskrif vir Hedendaagse Romeins-Hollandse Reg (Journal of Contemporary South African Roman-Dutch Law).
Research funding applications
- 12 - Association for International Cancer Research, Biotechnology and Biological Sciences Research Council (UK), Cancer Association of South Africa (CANSA), Christie Hospital NHS Trust, Dutch Cancer Society, European Commission, Fondation Carlos et Elise de Reuter, French Ministry of Research and Education, German-Israel Foundation for Scientific Research & Development, Josef Steiner Stiftung, March of Dimes, Katholieke Universiteit Leuven, Medical Research Council (South Africa), National Health Labortoty Services Trust (South Afroca), National Science Foundation (USA), NATO Collaborative Research Grants, National Research Foundation (South Africa), Natural Sciences and Engineering Research Council of Canada, Netherlands Organization for Scientific Research, Research Council of the University of Leuven, Swiss Cancer League, Swiss National Science Foundation, The Israel Science Foundation, The Wellcome Trust, United States-Israel Binational Science Foundation, Volkswagen Stiftung.
Candidates for academic positions and prizes
Deutsche Forschungsgemeinschaft; Imperial Cancer Research Fund; Max-Planck-Gesellschaft; South African Research Chair Initiative; Swiss National Science Foundation; University of Bern; University of Fribourg; University of California (Los Angeles); University of Cape Town; University of the Witwatersrand; The Wellcome Trust.
Other
Business plans for several entities. National Research Foundation (South Africa) – scientist rating.
EXTERNAL EXAMINER
Undergraduate course external examiner
Midrand Graduate Institute - Medical Biotechnology course (2008-2009)
University of the Witwatersrand - Biomedical Engineering: Molecular and Cell Biology HAEM2001 (2018-present) - Molecular Medicine course for second year MBBCh students (2009-2017) - School of Animal, Plant and Environmental Sciences (2010)
MSc Dissertation examiner - Prashika Singh, University of the Witwatersrand (South Africa). May 2018. Dissertation title: Targeted inactivation of hepatitis B virus genome using enhanced Transcription Activator-Like Effector Nucleases containing a sharkey FokI nuclease domain.
PhD Thesis examiner - Simnikiwe Horatious Mayaphi, University of Pretoria (South Africa). December 2018. Thesis title: Detection and characterisation of primary (acute and early) HIV-1 infections in an HIV hyper-endemic area. - Donald Moshen Tanyanyiwa, University of Cape Town (South Africa). December 2018. Thesis title: Type 2 Diabetes Mellitus and Dyslipidaemia: effects of genetic variation in African populations. - Tracey Hurrell, University of Pretoria (South Africa). January 2017. Thesis title: Proteomic assessment of potential in vitro hepatotoxicity models. - Britt Ingrid Drögemöller, Stelenbosch University (South Africa). October 2013. Thesis title: Investigation of genetic variation contributing to antipsychotic treatment response in a South African first episode schizophrenia cohort. - Anabela Correira Pereira Picton, University of the Witwatersrand (South Africa). May 2013. Thesis title: HIV-1 coreceptor CCR5: gene characterization anmd expresion. - H. J. Kotzé, North-West University (South Africa). July 2010. Thesis title: Evaluation of specific genotypes in the context of the type 2 diabetes risk phenotype in the black South African population. - 13 - - Dr. Benoit Jenny, University of Geneva (Switzerland). July 2010. Thesis title: A neural stem/progenitor cell based approach for brain repair. - Fabienne Baffert, Université Joseph Fourier Grenoble I (Grenoble). March 2001. Thesis title: Effets d’une exposition prolongée à l’hypoxie sur la réorganisation des cellules endothéliales ensemencées sur matrice de fibrine. - Etienne Régulier, Université Louis Pasteur (Strasbourg). January 2001. Thesis title: Thérapie génique du cancer par transfert adénoviral de genès codant des chimiokines, cytokines et facteurs anti-angiogéniques. - Thomas Christen, Université de Genève (Switzerland). November 2000. Thesis title: Porcine coronary artery smooth muscle cells: phenotypic features and implication in restenosis. - Ingrid Struman, Université de Liège (Belgium). May 1999. Thesis title: Etude des propriétés angiogéniques des membres de la famille prolactine/hormone de croissance humanie et de leurs fragments N-terminaux de 16 kDa. - Arianna Caprioli, Université de Paris 6 (France). December 1997. Thesis title: L’allantoïde, un des sites de production de cellules souches hématopoïétiques et de progéniteurs endothéliaux chez l’embryon d’Oiseau.
LLD Thesis examiner - Paul Tobias Mtunuse, University of South Africa (South Africa). May 2013. Thesis title: The right to confidentiality in the context of HIV/AIDS. - Sylvester Chidi Chima, University of South Africa (South Africa). May 2018. Thesis title: An investigation of informed consent in clinical practice in South Africa.
Habilitation Thesis examiner - Anne Eichmann, Institut d’Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne, et Université de Marne-la Vallée (France). Mémoire d’habilitation à diriger des recherches (HDR): Caracterisation moléculaire des précurseurs vasculaires embryonnaires. 1 December 2000. - Luc Pardanaud, Institut d’Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne, et Université de Marne-la Vallée (France). Mémoire d’habilitation à diriger des recherches (HDR): Aspects Cellulaires et Moléculaires du Developpement Vasculaire. 1 December 2000.
Other - Florence Gandillon, Swissbody Pilates, Geneva (Switzerland). Mémoire : La méthode Pilates dans un contexte de post-reeducation suite à une tetraparesie. 28 April 2013.
- 14 -
TEACHING
UNDERGRADUATE
Faculty of Health Sciences, University of Pretoria
Origin, trafficking and distribution of the cells of the immune system. 2nd year medical students - 1 hour (2017- present) Transplantation immunology. 2nd year medical students - 1 hour (2017-present) Angiogenesis and lymphangiogenesis; 2nd year medical students - 1 hour (2007, 2009-present) Cell-based therapy; 2nd year medical students - 1 hour (2006-present) Pharmacogenetics; 5th year medical students - 1 hour (2009, 2011-present) Bioentrepreneurship; 2nd year BSc students studying Medical Sciences or Physiology - 1 hour (2010) Pharmacogenetics; 2nd year medical students - 1 hour (2005)
University of Geneva Medical School
Problem-based learning curriculum (1995-2004, 2006-present) First year students Sciences biomédicales - Cours : Sciences biomédicales et pays en développement (1 hour) (2017-present) - Cours: Coeur et circulation probleme no. 4: (1 hour) (2019) Second year medical students - Tutor, “Heart and circulation” module (12-32 hours) (2001-2004, 2006-present) - Tutor, “Cell growth and ageing” module (32 hours) (1995-1999) - Tutor, integration module 1 (4 hours) (1997) - Monitor, practical anatomical pathology course, “Heart and circulation” module (8 hours) (2003 (responsible), 2006, 2008-2014, 2016-present) - Monitor, practical histopathology course, “Heart and circulation” module (4 hours) (1999, 2003/4/6/9/10/14) - Monitor, practical histology course, “Heart and circulation” module (4 hours) (1996-2004/7) Third year medical students - Co-responsible, “Locomotion” module (1999-2002) - Tutor, “Locomotion” module (32 hours) (1998-2003) - Lecture, integration module 2: Mécanismes de l'hypertrophie du myocarde et de l'insuffisance cardiaque (2003-2004) - Monitor, practical histology course, “Locomotion”module (4 hours) (1999-2003) - Monitor, practical histology course, “Defense & Immunity” module (4 hours) (2001-2004) - Examiner, pratical histology, module on “Locomotion” (2000-2004) - Examiner, pratical histology, module on “Defense & Immunity” (2001-2004)
Histology practical course, 1st and 2nd year medical students (1987-2004)
Histology lectures to paramedical students: blood cells, hematopoiesis, lymphoid system and blood and lymphatic vessels (4 hours) (1993-2003)
Lectures on the physiopathology of vascular diseases, 2nd year physiotherapists (4 hours) (2003)
Histology/cell biology lectures to second year medical students: Skeletal, cardiac and smooth muscle (8 hours) (1994-1997)
Faculty of Health Sciences, University of the Witwatersrand
Molecular Medicine course for 2nd year medical students: Cancer as a microevolutionary process (2018)
Medical Cell Biology III (ANAT 314) - applied cell biology: 24 hours (2004)
Morphological (Gross) anatomy - MBChB II and BSc Biomedical Sciences II students (ANAT 224) (2004) - 15 -
Histology lectures - MBChB II and BSc Biomedical Sciences II students (ANAT 224): bone and cartilage, lymphoid organs (2 hours) (2004)
University of Cape Town Medical School
Immunology practical course, medical students (1985/6)
POSTGRADUATE
University of Pretoria
Postgraduate Student and Supervisor Research Forum - Postgraduate Student Forum: From Thesis to Publication. 2017 - Postgraduate Student Forum: Converting your thesis into a research paper. 2015 - Early Career Academics Workshop: Supervision. 2013
Post-graduate workshops at the Faculty of Health Sciences - Academic writing course for basic sciences: scientific writing, structure of a scientific article, journal selection. 2011, 2012
Post-graduate seminars at the Faculty of Health Sciences - Department of Chemical Pathology: Cancer as a microevolutionary process. 2019 - Organ and tissue donation: the legislative environment in South Africa. Professional nurses. 2019. - Department of Paediatrics (Steve Biko Academic Hospital): The NESHIE project in South Africa. 2018. - ICMM Journal Club: Cancer as a microevolutionary process. 2018 - Molecular Pathology Course: Cancer as a microevolutionary process. 2018 - Research Forum Research Information Session: How do I enter the job market after graduation? 2018 - Department of Chemical Pathology: Stem cells: current reality and future promise. 2017 - Research Ethics of Human Genetics/Genomics. 2017 - Molecular Pathology Course: Stem cells: current reality and future promise. 2017 - Research Forum Research Information Session: Can collaboration improve the quality of my research? 2017 - Department of Obstetrics and Gynaecology (Steve Biko Academic Hospital): Hypoxic ischaemic encephalopathy. 2016 - Research Forum Postgraduate Student and Supervisor Forum: From thesis to publication. 2016 - School of Medicine “High Tea”: Research collaborations. 2015 - Department of Medical Microbiology: The lymphatic vascular tree – the often forgotten second vascular system. 2013 - Research Forum Postgraduate Student Forum: Bedside to bench - defining the market in Health Biotechnology in South Africa. 2012 - Department of Paediatrics (Steve Biko Academic Hospital): Monogenic disorders. 2012. - Department of Obstetrics and Gynaecology (Steve Biko Academic Hospital): Legislation pertaining to cell-based therapy in South Africa: selected aspects. 2012. - Department of Immunology: Mapping the human genome: the dawning of a new era in healthcare. 2010 - Department of Paediatrics (Kalafong Hospital): Overview of stem cell principles and legislation. 2010 - Department of Paediatrics (Steve Biko Academic Hospital): Neonatal hypoxic ischaemic encephalopathy: pathophysiology and litigation. 2010 - Department of Immunology: Cell-based therapy. 2009 - Netcare Jaccaranda Hospital: Cell-based therapy in South Africa. 2007 - Department of Chemical Pathology: Pharmacogenetics: from genotype to phenotype. 2007 - Faculty Research Day: Cell-based therapy. 2006 - Department of Pharmacology: Pharmacogenetics. 2005 - Department of Pharmacology: Angiogenesis. 2005 - Department of Physiology: Hemangiomas and vascular malformations: new insights into their pathogenesis and treatment. 2004 - 16 -
Post-graduate seminars at the Faculty of Natural and Agricultural Sciences - Department of Genetics: Sex determination and gender identity. 2015 - Centre for Microbial Ecology & Genomics: Stem cells - the hype and the hope. 2014 - Department of Genetics: Cell-based therapy. 2008 - Department of Genetics: Pharmacogenetics: from genotype to phenotype. 2007
University of the Witwatersrand
Post-graduate seminars at the Faculty of Health Sciences - Department of Molecular Medicine and Hematology: Stem cells – the hype and the hope. 2018 - Department of Molecular Medicine and Hematology: Sex determination and gender identity. 2015 - Department of Molecular Medicine and Hematology: Mapping the human genome: the dawning of a new era in healthcare. 2010 - Department of Molecular Medicine and Hematology: The power of pharmacogenetics. 2005 - Department of Molecular Medicine and Hematology: Vascular malformations and hemangiomas: from cell biology to the clinic. 2005 - School of Anatomical Sciences: The Netcare Institute of Cellular and Molecular Medicine. 2007 - Department of Molecular Medicine and Hematology: The lymphatic vascular system: a renaissance. 2004 - School of Anatomical Sciences: Transplantation of islets of Langerhans: beyond transplantation. 2004 - School of Anatomical Sciences: Vascular malformations and hemangiomas: new insights into their pathogenesis. 2004 - School of Anatomical Sciences: The lymphatic vascular system: a renaissance. 2003
Post-graduate seminars at the Johannesburg General Hospital - Department of Medicine: Vascular malformations and hemangiomas: new insights into their pathogenesis. 2004 - Department of Chemical Pathology: Lymphangiogenesis and tumor metastasis. 2003 - Department of Endocrinology: The pathogenesis of myocardial hypertrophy. 2003
University of Geneva
Post-graduate seminars at the Geneva University Medical Center and Hospital - Department of Genetics and Development. Genes lead the way: the promise of new technology. 2004 - Vascular biology seminar series: Vascular malformations and hemangiomas: new insights into their pathogenesis and treatment. 2004 - Department of Cellular Physiology and Metabolism: VEGF: a novel therapeutic for diabetes? 2004 - Dermatology clinic: Le système vasculaire lymphatique: une renaissance. 2004 - Division of Cardiology: Physiopathologie de l’hypertrophie du myocarde. 2003 - Division of Oncology: Lymphangiogenèse et métastases tumorales. 2003 - Cours de microimagerie: Laser capture microdissection. 2003 - Vascular biology seminar series: Lymphatic vascular system. 2003 - Department of Surgery: Le système vasculaire lymphatique: une renaissance. 2002 - Department of Geriatrics: Le système vasculaire lymphatique: une renaissance. 2002 - Department of Neurosurgery: Angiogenèse. 2001 - Division of Oncology: Lymphangiogenèse et métastases tumorales. 2001 - Division of Medical Genetics: Angiogenèse et morphogenèse vasculaire. 2000 - Plastic and Reconstructive Surgery Unit: Physiopathologie des hémangiomes et malformations vasculaires. 2000 - Department of Medicine: Angiogenèse: où en est-on? 1999 - Department of Surgery: Angiogenèse: de la biologie cellulaire aux applications cliniques. 1999 - Division of Radio-oncology: Angiogenèse. 1998 - Division of Angiology & Hemostasis: Pathogénie des malformations vasculaires: rôle des facteurs de croissance. 1997 - Department of Medicine: Néo-angiogenèse. 1997 - 17 - - Endocrinology seminar series: Régulation positive et négative de l'angiogenèse. 1996 - Pediatric clinic: Lésions vasculaires pédiatriques. 1995 - IIIe Cycle Romand en sciences biologiques. Angiogenèse et Cancer. 1994 - Division of Angiology & Hemostasis: Angiogenèse et pathologie vasculaire. 1994 - Dermatology clinic: Angiogenèse et la peau. 1994 - Department of Pharmacology: Angiogenèse in vitro. 1991 - Division of Oncology: Néo-angiogenèse. 1991
Conferences du C.M.U. University Medical Center, Geneva - Le système vasculaire lymphatique: une renaissance. 2002 - Régulation positive et negative de l'angiogenèse: de la biologie cellulaire aux applications cliniques. 1995
Histology for post-graduate students, Department of Morphology. Blood cells and hematopoiesis; blood and lymphatic vessels; cartilage and bone (6 hours). 2002-2004
Ph.D. students’ program on molecular and cellular biology (9 hours). 2000-2004
Ph.D. students’ course on the biology of connective tissues (4 hours). 1992-1994
University of Lausanne and Ecole Polytechnique Fédérale de Lausanne
Post-graduate seminars at the Lausanne University Hospital - Institute of Pathology: Lymphangiogenesis and tumor metastasis. 2002 - Division of Surgical Research: Manipulating angiogenesis: from basic science to the bedside. 1997 - Department of neurosurgery: Angiogenesis: a balance between positive and negative regulators. 1996
Post-graduate seminars at the Ecole Polytechnique Fédérale de Lausanne - Department of Rural Engineering: Angiogenèse et assemblage de la paroi vasculaire. 1998
University of Cape Town
Faculty of Medicine - B.Sc. (honours) immunology course: Lymphocyte ontogeny and differentiation. 1985/6
STUDENTS
PRE-GRADUATE STUDENTS
- Thandeka Msimang (Medical student, University of Pretoria) 1 month elective, 2007 - Sophie Excoffier (Medical student, University of Geneva) 2 month training period, 2003 - Thomas Agoritsas (Medical student, University of Geneva) 2 month training period, 2001 - Patrick Myers (Medical student, University of Geneva) 2 month training period, 1999 - Gérald Hentsch (Medical student, University of Lausanne) 3 month training period, 1998
POST-GRADUATE STUDENTS
Diploma students Faculty of Science, University of Geneva - Hélène Mottaz (Department of Morphology) Oct 2002 - March 2004 - Marie Zbinden (Department of Morphology) Oct 2002 - March 2004
Honours students Faculty of Health Sciences, University of Pretoria - 18 - - Carla Dessels (Department of Anatomy) 2011 - Jacobus Rademan (Department of Pharmacology) 2010 - Tyren Dodgen (Department of Pharmacology) 2007 - Eloise Fraenkel (Department of Anatomy) 2007 - Johannie du Plessis (Department of Pharmacology) 2006 - Monique du Preez (Department of Pharmacology) 2006 - Warren Hochfeld (Department of Pharmacology) 2006 Faculty of Natural and Agricultural Sciences, University of Pretoria - Graeme Ford (Department of Biochemistry) 2019 - Antoinette Colic (Department of Biochemistry) 2014
MSc students Faculty of Health Sciences, University of Pretoria - Rachel Giles (Department Medical Immunology) 2019-present - Jamie Mollentze (Department Medical Immunology) 2019-present - Ignatius Gous (Department Medical Immunology) 2019-present - Simone Grobbelaar (Department of Physiology) 2018-present - Aurona Gerber (Department of Medical Immunology) 2018-present - Anastasios Athanasiadis (Deperment of Medical Immunology) 2017-present - Catherine Wickham (Department of Medical Immunology) 2016-present - Candice Herd (Department of Medical Immunology) 2016-present - Chantel Gouveia (Department of Reproductive Biology). 2015-2019. Dissertation entitled: Optimization of techniques required for somatic cell nuclear transfer using a mouse model. MSc obtained in April 2019. - Carla Dessels (Department of Medical Immunology) 2013-2017. Dissertation entitled: Expansion of aipose- derived stem/stromal cells: human alternatives to foetal bovive serum. MSc obtained in May 2017. - Danielle de Villiers (Department of Medical Immunology) 2012-2016. Dissertation entitled: The effect of oxidative stress and hypoxic conditioning on mesenchymal stem cell differentiation. MSc obtained in April 2016. - Jeanne van Rensberg (Department of Medical Immunology) 2012-2016. Dissertation entitled: Rarefaction as a tool to determine variant diversity in monogenetic disorders. MSc obtained in April 2016. - Fiona van Vollenstee (Department of Medical Immunology). 2010-2015. Dissertation entitled: Isolation and characterization of human adipose derived mesenchymal stem cells and production of GFP-labeled primary cells for in vivo tracking following transplantation. MSc Obtained in April 2015. - Juanita Mellet (Department of Medical Immunology) 2011-2013. Dissertation entitled: Factors determining the composition of a public cord blood stem cell bank including HLA diversity. MSc obtained in September 2013. - Karlien Kallmeyer (Department of Medical Immunology) 2010-2013. Dissertation entitled: Isolation and characterization of mesenchymal stem cells from human tissues. MSc obtained in September 2013. - Fatima Barmania (Department of Medical Immunology) 2010-2012. Dissertation entitled: Analysis of CCR5 diversity in the South African population. MSc obtained in April 2012. - Monique du Preez (Department of Medical Immunology) 2008-2012. Dissertation entitled: Implementation of a blood conservation program in a private hospital setting in South Africa. MSc obtained in April 2012. - Doretha Thompson (Department of Medical Immunology) 2007-2010. Dissertation entitled: Flow cytometric analysis of stem cells derived from umbilical cord blood. MSc obtained in April 2010. - Murray Logan (Department of Medical Immunology) 2006-2009. Dissertation entitled: Investigation of MC4 Receptor Polymorphisms and the Effect of Bariatric Surgery on a Selected Group of South African Obese Patients. MSc obtained in September 2009.
PhD students Faculty of Health Sciences, University of Pretoria - Rosemary Kabahuma (Department of Medical Immunology) 2018-present - Bukola Agbedare (Department of Mecical Immunology) 2018-present - Elize Wolmarans (Department of Medical Immunology) 2014-present - Karlien Kallmeyer (Department of Medical Immunology) 2014-present - Juanita Mellet (Department of Medical Immunology) 2013-present - Mqondisi Tshabalala (Department of Medical Immunology) 2014-present - 19 - - Nicolette du Plessis (Department of Paediatrics). 2015-2019. Thesis entitled: An evaluation of factors associated with early infant HIV acquisition, infant outcomes, and 9-12 month infant HIV seroreversion in the context of PMTCT Option B+: prospective data from an HIV exposed birth cohort. PhD obtained in April 2019. - Carlo Jackson (Department of Medical Immunology) 2010-2017. Thesis entitled: The expansion and transduction of hematopoietic stem cells for gene therapy. PhD obtained in May 2017 - Tyren Dodgen (Department of Pharmacology) 2008-2013. Thesis entitled: Pharmacogenetics of CYP2D6 and CYP2C19 as a pre-prescription tool for drug efficacy and toxicity in a demographically-representative sample of the South African population. PhD obtained in September 2013 (Upgrade from MSc) - Madeleine Meissner-Roloff (Department of Medical Immunology) 2010-2013. Thesis entitled: The effect of HIV on the formation of colony forming units in vitro & public willingness to donate to a public cord blood bank. PhD obtained in April 2013 - Peaceful Mabeta (Department of Physiology) 2004-2008. Thesis entitled: The effect of bleomycin, mitomycin C, and cytoskeletal-disrupting drugs on angiogenesis in vitro and haemangioma development in vivo. PhD obtained in December 2008 Faculty of Medicine, University of Geneva - Riccardo Nisato (Department of Cell Physiology and Metabolism) 2000-2005. Thesis eititled: Role of integrins, metalloproteinases and VEGFRs in angiogenesis in vitro and in lymphangiogenesis in vitro and in vivo. PhD obtained in September 2005 - Jean-Christoph Tille, MD (Department of Morphology) 1999-2003. Thesis entitled: Le rôle des récepteurs à VEGF dans la régulation de l’angiogenèse. PhD obtained in October 2003 - Stefano Mandriota (Department of Morphology) 1993-1999. Thesis entitled: Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin family members. PhD obtained in September 1999
MD student Geneva University Hospital, Switzerland - Pierre Quinodoz (Plastic and Reconstructive Surgery) 1997-1999. Thesis entitled: Amélioration de la survie des lambeaux cutanés: une nouvelle technique utilisant des cellules encapsulées transfectées avec bFGF. MD obtained in 1999
Post-doctoral students Faculty of Health Sciences, University of Pretoria - Cheryl Stewart (Department of Immunology) 2012-2017 - Mamoonah Chaudhry (Department of Immunology) 2016-2017 - Samantha Nicholson (Department of Immunology) 2016-2017 - Melvin Ambele (Department of Immunology) 2014-2016 - Asma Erjaee (Department of Immunology) 2015-2016 - Morteza Bagherpour (Department of Immunology) 2015-2016 - Ovokeraye Achinike-Oduaran (Department of Immunology) 2014-2016 - Ahmed Oloyo (Department of Immunology) 2014-2016 - Marco Alessandrini (Department of Immunology) 2011-2016 - Shanthi Sharon Kappala (Department of Immunology) 2013-2015 - Christa Durandt (Department of Immunology) 2006-2007; 2012-2013 - Marnie Potgieter (Department of Immunology) 2010-2013 - Heidi Fickl (Department of Immunology) 2008-2009 University Medical Center, Geneva - Jillian Harrison (Department of Morphology/Cell Physiology and Metabolism). 2003-2004 - Raphaële Buser (Department of Morphology/Cell Physiology and Metabolism). 2002-2004 - Kai-Uwe Schlaudraff (Plastic & Reconstructive Surgery, Geneva University Hospital). 2000-2002 - Lin Cui (Department of Morphology/Cell Physiology and Metabolism). 2000-2002 - Navid Alizadeh (Plastic and Reconstructive Surgery, Geneva University Hospital). 1998-2000 - Ghamartaj Hosseini (Department of Morphology/Cell Physiology and Metabolism). 1997-2000 - Lee Gorden (Department of Morphology/Cell Physiology and Metabolism). 1994-1996 - Ginetta Collo (Department of Morphology/Cell Physiology and Metabolism). 1995 - Nicola Maggiano (Department of Morphology/Cell Physiology and Metabolism). 1986-1987
Thesis co-supervisor - 20 - Honours students - Riaan Dowling (Department of Electrical, Electronic and Computer Engineering, University of Pretoria) 2019. - Ladislaus Adam (Department of Immunology, University of Pretoria) 2015-2016. Dissertation entitled: Do adipose-derived stromal cells possess endocytic functions? Degree obtained in 2016 - Karel de Bruin (Department of Electrical, Electronic and Computer Engineering, University of Pretoria) 2013. Degree obtained in 2013 - Kristen Klose (Graduate School of Technology Management, University of Pretoria) 2010. Dissertation entitled: Understanding technology transfer at higher education institutes (HEIs): A South African study. Degree obtained in 2010 Masters students - Priyanka Dhanraj (Department of Immunology, University of Pretoria) 2019-present - Nomvuselelo Nyathi (Department of Physiology, University of Pretoria) 2018-present - Carina da Silva (Department of Immunology, University of Pretoria) 2016-present - Ladislaus Adam (Department of Immunology, University of Pretoria). 2016-2019. Dissertation entitled: Effects of reactive oxygen species scavengers on adipogenesis. MSc obtained in April 2019. - Karel de Bruin (Department of Electrical, Electronic and Computer Engineering, University of Pretoria). 2014-2019. Dissertation entitled: Prediction of the proliferation capacity of adipose-derived stromal cells in vitro. MEng obtained in April 2019. - Melanie Skeen (Department of Physiotherapy, University of Pretoria) 2009-2015. Dissertation entitled: A critical analysis of the functional outcome of people with spinal cord injuries who have received stem cell therapy. MSc obtained in April 2015 - Keshree Gayaparsad (Institute of Pathology, University of Pretoria) 2006-2007. Thesis entitled: An immunohistopathological review of vascular malformations and other vascular lesions using novel lymphatic specific endothelial markers Podoplanin and D2-40. MMed (Anatomical Pathology) obtained in 2007 Doctoral students - Nare Sekoba (Department of Physiology, University of Pretoria) 2018-present - Camille Castelyn (Centre for Philosophy & Ethics of Health Sciences, University of Pretoria) 2018-present - Victoria Damerell (Department of Human Biology, University of Cape Town). 2018-present - Johan Viljoen (Department of Electrical, Electronic and Computer Engineering, University of Pretoria) 2014-present - Ahmad Haeri Mazanderani (Department of Medical Virology, University of Pretoria). 2016-2019. Dissertation entitled: Evaluating the performance of HIV testing in infants exposed to antiretroviral prophylaxis within South Africa’s prevention of mother to child transmission programme. PhD obtained in April 2019. - Joji Theron (Department of Physiology, University of Pretoria) 2012-2016. Thesis entitled: In vitro and in vivo anti-cancer properties of novel spindle disruptors. PhD obtained in September 2016. - Renier Myburgh (Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich) 2011-2015. Engineering an HIV resistant immune system. PhD obtained in January 2015 - Dominik Lévigne (Department of Plastic and Reconstructive Surgery, University of Geneva) 2011-2014. Thesis entitled: More than a nutrient: the role of oxygen in the pathophysiology and therapy of chronic wounds in ischemic and hyperglycemic conditions. PhD obtained in October 2014 - Safia Mahomed (Department of Jurisprudence, Unisa) 2011-2013. Thesis entitled: A legal framework for the regulation of stem cell research and therapy in South Africa. LLM obtained in 2013
Prizes awarded to post-graduate students
Dr. Pierre Quinodoz Swiss Society for Plastic Reconstructive and Aesthetic Surgery. Title of presentation: Amélioration de la survie des lambeaux cutanés: une nouvelle technique utilisant des cellules encapsulées transfectées. 1999.
Dr. Navid Alizadeh Swiss Society for Plastic Reconstructive and Aesthetic Surgery. Title of presentation: Active-site inactivated FVIIa (FVIIai) increases survival in a random skin falp model of acute ischemia. 2001.
Dr. Jean-Christophe Tille - 21 - Prix Arditi de la Faculté de Médecine de Genève. For PhD thesis entitled “Le rôle des récepteurs à VEGF dans la régulation de l’angiogenèse”. 2005.
Dr. Ajay Mahajan Progressive tissue injury in burns is reduced by rNAPc2. Prize for the best paper at the British Burns Association (BBA) meeting. York, UK, April 2005.
Peace Mabeta 1. South African Women in Science Award, Gender responsive research. Finalist (second place). 2005. 2. Microscopy Society of Southern Africa, Innovative Research. 1st position. 2006. 3. Junior researcher of the year, 3rd Place. Faculty of Health Sciences, University of Pretoria, 2007. 4. Best publication, basic sciences category. Faculty of Health Sciences, University of Pretoria. 2010. 5. Best overall publication, non-clinical. Faculty of Health Sciences, University of Pretoria. 2012.
Tyren Dodgen 1. Best oral presentation, 2nd place. Utilization of the Roche Amplichip platform for pre-prescription genotyping. South African Genetics Society (SAGS) Congress, Pretoria, 2008. 2. Best junior researcher, 2nd place. Phenotyping of CYP450-mediated drug metabolism in a demographically representative sample of the South African population. Faculty Day, University of Pretoria, 2008. 3. Young Scientist Award, 2nd place. Drug metabolite phenotyping of CYP2D6 and CYP2C19 enzyme activity in a demographically representative sample of the South African population. South African Society for Basic and Clinical Pharmacology congress, Rhodes University, 2008. 4. Best junior researcher, 1st place. Pre-prescription genotyping of CYP2D6 and CYP2C19 in a demographically representative group of the South African population. Faculty Day, University of Pretoria, 2009. 5. Young Scientist Award, 2nd place. Genotype vs. phenotype and the allelic variation of CYP2D6 and CYP2C19 in a demographic sample of the South African population. International Congress on Pharmaceutical and Pharmacological Science, University of the North West.2009. 6. Best PhD oral presentation, 2nd place. Is the Roche AmpliChip CYP450 Test the correct pharmacogenetic screening assay for CYP2D6 and CYP2C19 in the South African population? South African Genetics Society (SAGS) Congress, Bloemfontein. 2010. 7. Best junior researcher, 3rd place. Pharmacogenetics of CYP2C19 for personalising medication in the South African population. Faculty Day, University of Pretoria, 2010.
Dr. Marnie Potgieter 1. Junior researcher, basic science, 3rd prize: Human mesenchymal stem cells: isolation, characterization and differentiation (M Potgieter, F van Vollenstee, K Kallmeyer, C Jackson, C Dessels, MS Pepper), Faculty Day, University of Pretoria, 31 August 2011. 2. Junior researcher, basic science, 3rd prize: The effect of light activation on mesenchymal stem cell phenotype (M Potgieter, C Durandt, D de Villiers, MS Pepper), Faculty Day, University of Pretoria, 29 August 2012.
Fiona van Vollenstee 1. Basic sciences posters, 2nd prize (joint award): Evaluation of the PROCLEIX ULTRIO Plus assay for the detection of HIV-1 in the umbilical cord- and adipose tissue derived mesenchymal stem cells (F Van Vollenstee, L Gaggia, D Hoffman, K Kallmeyer, M Potgieter, P Coetzee, M Vermeulen, MS Pepper). Faculty Day, University of Pretoria, 20-21 August 2013.
Karel de Bruyn 1. Students posters, 3rd prize (joint award): A theoretical probabilistic approach to mesenchymal stem cell proliferation modelling (K De Bruin, M Potgieter, P de Villiers, MS Pepper). Faculty Day, University of Pretoria, 20-21 August 2013.
Melanie Skeen 1. Best platform presentation, 3rd prize: A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury (M Skeen, C Eksteen, MS Pepper). 52nd International Spinal Cord Society Annual Scientific Meeting, Istanbul, Turkey, 28-30 October 2013. - 22 -
Karlien Kalmeyer 1. Basic sciences posters, 1st prize: Differences in basic biological characteristics exist between adipose- and Wharton’s jelly-derived mesenchymal stromal cells (K Kallmeyer, FA van Vollenstee, C Durandt, M Potgieter, MS Pepper). Faculty Day, University of Pretoria, 19-20 August 2014. 2. Basic sciences posters, 1st prize: In vivo tracking of adipose-derived mesenchymal stromal cells during physiological wound repair (K Kallmeyer, D Levigne, A Modaressi, B Pittet-Cuenod, MS Pepper). Faculty Day, University of Pretoria, 23-24 August 2016. 3. Best oral presentation: 2nd International Conference on Tissue Engineering and Regenerative Medicine, Vanderbijlpark, South Africa, 26-30 July 2017.
Dr. Marco Alessandrini 1. Basic sciences posters, 3rd prize: Mesenchymal Stem Cell Therapy: Overview of Clinical Indications (M Alessandrini, M Potgieter, MS Pepper). Faculty Day, University of Pretoria, 19-20 August 2014.
Renier Myburgh 1. Posters, 2nd prize. Gene engineering an HIV resistant immune system (R Myburgh, MS Pepper, P Salmon, KH Krause and RF Speck RF). World Innovation Day “Innovation for Health Competition”, Geneva, Switzerland, 28‐29 August 2014.
Antoinette Colic 1. Oral presentation, 1st prize. Pharmacogenetics of CYP2B6, 2A6 and UGT2B7: relevance to HIV treatment in African populations (A Colic, M Alessandrini and MS Pepper). Genomics Research Institute Seminar Day, University of Pretoria, 31 October 2014.
Dr. Sharon Kappala 1. Oral presentation, 1st prize. Evaluation of AMLprofiler for acute myeloid leukemia patients in South Africa (Kappala S, Alessandrini M, Matlhako T, Beltchev E, Pool R and Pepper MS). NHLS Pathology Research and Development Congress, Johannesburg, 15-16 April 2015. 2. Oral presentation clinical, 3rd prize. Evaluation of the AML profiler: a novel diagnostic tool for acute myeloid leukemia patients in South Africa (SS Kappala, M Alessandrini, T Matlhako, E Beltchev, R Pool and MS Pepper). Faculty Day, Faculty of Health Sciences, University of Pretoria, 18-19 August 2015.
Dr. Cheryl Stewart 1. Oral presentation clinical, 2nd prize. Cystic fibrosis: an African public health roadmap (C Stewart, J van Rensburg, O Oduran, R Masekela, R Green, M Zampoil, T Kelberker, T Westwood, and MS Pepper). Faculty Day, Faculty of Health Sciences, University of Pretoria, 18-19 August 2015.
Jeanne van Rensburg 1. Oral presentation basic sciences, 1st prize. Cystic fibrosis and rarefaction: unification through diversity (J van Rensburg, M Alessandrini, M Robertson and MS Pepper). Faculty Day, Faculty of Health Sciences, University of Pretoria, 18-19 August 2015. 2. Oral presentation, 2nd prize. Cystic fibrosis and rarefaction: unification through diversity (J van Rensburg, M Alessandrini, M Robertson and MS Pepper). Genomics Research Institute Symposium, University of Pretoria, 29 October 2015.
Chantel Gouveia 1. Best oral presentation in Masters and Honours category. Experimental setup of somatic cell nuclear transfer: procedural optimization (C. Gouveia, C Huyser, MS Pepper). Southern African Society for Reproductive Medicine and Gynaecological Endoscopy, National Congress, Johannesburg, 30 October - 01 November 2015. 2. Best electronic poster in Masters and Honours category. Experimental setup of somatic cell nuclear transfer: procedural optimization (C. Gouveia, C Huyser, MS Pepper). Southern African Society for Reproductive Medicine and Gynaecological Endoscopy, National Congress, Johannesburg, 30 October - 01 November 2015. 3. Basic sciences posters, 3rd prize: Experimental setup of somatic cell nuclear transfer: procedural optimization (C Gouveia, C Huyser, MS Pepper). Faculty Day, University of Pretoria, 23-24 August 2016. 4. Poster session, 2nd place: Outcomes of somatic cell nuclear transfer using a mouse model. (C Gouveia, C Huyser, MS Pepper). ISGE SASREG Embryology Pre-Congress Workshop, Cape Town, 13-14 Apri, 2019. - 23 -
Dr Mamoonah Chaudhury Oral presentation clinical, 3rd prize: Variation in the CYP2D6 gene may predict amitriptyline efficacy in patients with diabetic peripheral neuropathy (M Chaudhry, M Alessandrini, J Rademan, TM Dodgen, FE Steffens, D Van Zyl, A Gaedigk, MS Pepper). Faculty Day, University of Pretoria, 23-24 August 2016.
- 24 -
RESEARCH
RESEARCH FUNDING
Project title or student name Funding body Amount Date Notes WHO Genomics meeting Department of Science R 50 000 2019 and Technology WHO Genomics meeting Wellcome Trust £ 12 000 2019 Aurona Gerber National Research R 50 000 2018 Personal Use Foundation Freestanding Masters Block Grant International Society for UP Conference R 34 716.53 2018 Cellular Therapy, 2018 Funding Programme Global Regulatory Perspective pre-Conference Workshop Pharmocogenetics profiling of National Health R 496 520 2018-2020 painful diabetic peripheral Laboratory Services neuropathy patients treated Research Trust with low dose amitriptyline Is there a genetic South African Medical R 17 867 897 2017-2022 predisposition to death and Research Council disability after moderate- severe hypoxic ischemic encephalopathy in cooled infants? A genome-wide association study in a South African cohort. Extramural Unit: Stem Cell South Afrcian Medical R 1 000 000pa 5 years Research and Therapy Research Council 2015-2019 A molecular investigation of National Health R 100 000 2017-2018 Cystic Fibrosis in South Laboratory Services Africa Research Trust Juanita Mellet Poliomyelitis Research R 55 000 2016-2018 Personal use Foundation PhD Bursary Juanita Mellet National Research R 400 000 2013-2018 Personal use Foundation Innovation Doctoral Scholarship Catherine Wickham Poliomyelitis Research R 40 000 pa 2016-2017 Personal use Foundation Masters Bursary Catherine Wickham National Research R 170 000 2016-2017 Personal use Foundation Scarce Skills Masters Scholarship Candice Herd Poliomyelitis Research R 40 000 pa 2016-2017 Personal use Foundation Masters bursay Candice Herd National Research R 170 000 2016-2017 Personal use Foundation Scarce Skills Masters Scholarship Elize Wolmarans National Research R 290 000 3 years Personal use Foundation / 2015-2017 - 25 -
Deutscher Akademischer Austausch Dienst PhD Scholarship Karlien Kallmeyer National Research R 420 000 4 years Personal use Foundation Scarce 2014-2017 Skills Development Fund Doctoral Scholarship Chantel Gouveia National Research R 76 956 2015-2016 Personal use Foundation Internship Study of the transcriptome National Health R 491 600 2015 profiles of mesenchymal stem Laboratory Services cells from human tissues Research Trust Fluidigm C1/Biomark single National Research R 11 970 000 2014/2015 Includes 1/3 cell transcriptomics and Foundation: contribution from genomics platform Infrastructure Funding UP Instruments (NEP/NNEP) Dr Ahmed Oloyo University of Pretoria R 200 000pa 2 years Personal use Vice-Chancellor's 2014-2016 Post-Doctoral Fellowship Programme Lara Contu Deutscher R 90 000pa 3 years Personal use Akademischer 2014-2016 Austausch Dienst (German Academic Exchange Service) PhD bursary Evaluation of the National Health R 90 000 2014-2016 effectiveness of a microarray Laboratory Services based diagnostic tool Research Trust (AMLprofiler) for acute myeloid leukaemia (AML) relative to current diagnostic modalities in the South African context Stem cell research and Medical Research R 16 500 000 2014-2016 Category 1 award therapy: addressing South Council: SA Africa’s disease burden University Flagship Projects Gene engineering HIV Swiss South African R 1 200 000 2014-2016 Co-applicant with resistant cells Joint Research Profs. Roberto Programme Speck (Zurich) and Krause (Geneva) Elize Wolmarans National Research R 92 347.20 2014-2015 Personal use Foundation Internship Sasha Reznichenko National Research R 92 347.20 2014-2015 Personal use Foundation Internship Dr Sharon Kappala University of Pretoria R 200 000pa 2 years Personal use Vice-Chancellor's 2013-2015 Post-Doctoral Fellowship Programme Development of National Research R 931 000 2013-2015 Co-applicant with - 26 - computational resources to Foundation: National Prof. Alan support analysis of Southern Bioinformatics Christoffels and the African Human genomes Functional Genomics Southern African Programme (NBIG) Human Genome Programme Mesenchymal stem cell National Research R 317 470 2013-2015 transcriptome analysis Foundation: National Bioinformatics Functional Genomics Programme (NBIG) Karlien Kallmeyer Ernst and Ethel R 12 000 2014 Personal use Eriksen Trust PhD bursary Transcriptome analysis of Institutional Research R 84 000 2014 hematopoietic stem cells Theme for Genomics, expanded in culture University of Pretoria FacsAria Fusion Cell Sorter National Research R 12 084 000 2014 Includes 1/3 Foundation: contribution from Infrastructure Funding UP Instruments (NEP/NNEP) Carla Dessels Deutscher R 60 000pa 2013-2014 Personal use Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary Jeanne van Rensburg National Research R 72 600 2013-2014 Personal use Foundation Internship Genomics research on Wellcome Trust R 70 000 2013 indigenous populations: exploring the concept of genomic sovereignty with the San community of southern Africa Danielle de Villiers Faculty of Health R 40 000 2013 Personal use Sciences, University of Pretoria - Research Assistant post Isabella Rangaka Faculty of Health R 40 000 2013 Personal use Sciences, University of Pretoria - Research Assistant post Cell delivery for soft tissue Council for Scientific R 30 000 2013 augmentation and Industrial Research A molecular investigation of University of Pretoria R 100 000 2013 cystic fibrosis in South Africa A molecular investigation of Institutional Research R 167 120 2013 cystic fibrosis in South Africa Theme for Genomics, University of Pretoria Dr. Cheryl Stewart University of Pretoria R 200 000pa 2012-2014 Personal use Vice-Chancellor's Post-Doctoral Fellowship Programme - 27 -
Madelein-Meissner Roloff Faculty of Health R 40 000 2012 Personal use and Karnien Kallmeyer Sciences, University of Pretoria - Research Assistant post Jeanne van Rensberg Faculty of Health R 40 000 2012 Personal use Sciences, University of Pretoria - Research Assistant post Southern African Human Department of Science R 2 000 000 2012 Co-applicant with Genome Programme and Technology Prof. Michele Ramsay Public cord blood bank Medical Research R 322 660 2012 feasibility study Council Isabella Rangaka Medical Research R 60 000 2012 Personal use Council Juanita Mellet and Danielle de National Research R 144 000 2012-2013 Personal use Villiers Foundation Internship Dr. Marco Alessandrini National Research R 190 000pa 2012-2014 R 160 000 personal Foundation Scarce use Skills Development R 30 000 research Fund Dr. Chrisna Durandt University of Pretoria R 150 000pa 2012-2013 Personal use Clinical research co- ordinator Dr. M. Potgieter University of Pretoria R 680 000 2010-2013 Personal use Research Fellowship Programme Dr. M. Potgieter Medical Research R 250 000 2011-2012 Personal use Council Post-doctoral scholarship Tyren Dodgen Deutscher R 65 000 2011 Personal use Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary Isabella Rangaka National Research R 87 120 2011-2012 Personal use Foundation Internship Karlien Kallmeyer National Research R 60 000pa 2011-2012 Personal use Foundation Free- standing and Innovation Scholarship Carlo Jackson Deutscher R 65 000pa 2011-2014 Personal use Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary Fiona van Vollenstee Faculty of Health R 40 000 2011 Personal use Sciences, University of Pretoria - Research Assistant post Carlo Jackson and Karlien Faculty of Health R 40 000 2011 Personal use Kallmeyer Sciences, University of Pretoria - Research - 28 -
Assistant post Southern African Human Department of Science R 450 000 2010-2011 Co-applicant with Genome Programme and Technology Prof. Michele Ramsay Soft tissue augmentation – Council for Scientific R 150 000 2010-2011 cell delivery using and Industrial DermapearlTM Research Carlo Jackson Faculty of Health R 40 000 2010 Personal use Sciences, University of Pretoria - Research Assistant post Karlien Kallmeyer, Fiona van National Research R 132 000 2010-2011 Personal use Vollenstee Foundation Internship Fatima Barmania Innovation Master’s R 60 000 2010 - Personal use Scholarship 2011 Cytochrome P450 2D6 National Health R 324 500 2010-2011 polymorphisms in weight gain Laboratory Services and movement disorders Research Trust associated with risperidone treatment Gene Therapy for HIV/AIDS National Research R 1 920 000 2009-2011 Foundation – Blue Skies Research Programme Arinda Eloff, Amy Kopke National Research R 132 000 2009-2010 Personal use Foundation Internship Understanding technology World Bank Institute R 85 000 2009 transfer at South African universities: towards establishing trends and best practice for the establishment of Communities of Practice among Southern African and African universities Investigation of MC4 receptor National Health R 51 300 2009 polymorphisms in the South Laboratory Services African obese population Research Trust CYP2D6 polymorphisms National Research R 200 000 2008-2009 associated with risperidone Foundation - Unlocking the future CYP2D6 and CYP2C19 National Research R 209 000 2007-2008 pharmacogenetics as a pre- Foundation - Focus prescription predictive tool for Area Call drug toxicity and efficacy in the South African population Pharmacogenetics of CYP2D6 National Research R 151 000 2007 Awarded to Dr. and CYP2C19 Foundation - Chrisna Durandt Thuthuka. Women in research Utilization of AmpliChip AMPATH National R 648 000 2006-2009 pharmacogenetic technology Pathology Support for pre-prescription Services genotyping Dr. Chrisna Durandt University of Pretoria, R 330 000 2006-2008 Pretoria, Research Fellowship - 29 -
Pre-treatment genotyping as a National Health R 60 000 2006 predictor of therapeutic Laboratory Services outcome Research Trust Molecular mechanisms of Swiss National SFr 319 925 2004-2007 Grant returned to lymphangiogenesis and Science Foundation the Swiss National lymphatic tumor cell Science Foundation dissemination because of departure from Switzerland Genomic analysis of Merck KGaA, € 184 800 2003-2005 endothelial cells during Darmstadt, Germany angiogenesis Lymphatic endothelial cells: Novartis Pharma AG, SFr 211 716 2003-2004 isolation, characterisation and Basel, Switzerland development of functional assays Effect of SSR128129, an Sanofi-Synthelabo SFr 62 666.24 2003 FGF-R1 antagonist, on Recherche, Toulouse, angiogenesis in vitro and France lymphangiogenesis and tumor metastasis in vivo Pathophysiology and Société Académique SFr 15 000 2002 consequences of tissue de Genève ischemia Effects of 8-prenylnaringenin, Swiss Foundation for SFr 20 000 2002 a novel highly phytoestrogen, Nutrition Research on angiogenesis and the endothelial cell proteolytic repertoire Evaluation of rNAPc2 in Corvas International SFr 43 000 2002 random dorsal skin flap model Inc of acute ischemia Pathophysiology and Crédits SFr 40 000 2002 consequences of tissue d’investissement de la ischemia Faculté de Médecine, Université de Genève Hypoxia-regulated gene Fondation Novartis SFr 43 157 2001 expression in endothelial cells – a therapeutic target ? Mechanisms of Swiss National SFr 335 000 2001-2004 lymphangiogenesis and its Science Foundation role in tumor metastasis Genomic analysis of Merck KGaA, € 153 387 2000-2002 endothelial cells during Darmstadt angiogenesis Hypoxia-regulated gene Recherche Suisse SFr 139 500 2000-2002 expression in endothelial cells Contre le Cancer - a therapeutic target? Hypoxia-regulated gene Rentenanstalt Swiss SFr 20 000 2000 expression in endothelial cells Life - a therapeutic target? Regulation of angiogenesis: Fondation Suisse de SFr 125 000 2000 the role of endothelial- Cardiologie perivascular cell interactions and hypoxia Angiogenesis and vascular Fondation SFr 23 327 1999 - 30 - morphogenesis Schmidheiny Positive and negative Fondation Carlos et SFr 25 000 1997 regulation of angiogenesis: Elise de Reuter clinical applications of basic science research Establishing an "angiogenic Ligue Genevoise SFr 19 517.25 1996 profile" for cancer patients contre le Cancer Angiogenesis and Fondation Sandoz SFr 25 000 1994 tubulogenesis in the rodent pour l'avancement des mammary gland and sciences medico- endocrine pancreas biologiques Co-applicant with Prof. Sharon Prince (Dept. of Human Biology, Faculty of Health Sciences, University of Cape Town) TBX3 in combination with c- Cancer Association of ZAR 1,200,000 2017-2019 Myc and Nucleolin as South Africa multiple markers for the early detection of sarcomas Co-applicant with Dr. A. Modarressi (Div. Plastic and Reconstructive Surgery, Geneva University Hospital, Geneva, Switzerland) Novel strategies to improve Swiss National SFr 474 000 2016-2019 wound repair: from wound Science Foundation oxygenation to stem cell therapy Co-applicant with Dr. M.-L. Bochaton-Piallat (Dept. Pathology, University Medical Center, Geneva, Switzerland) Arterial smooth muscle Swiss National SFr 227 000 2002-2005 heterogeniety: implications Science Foundation for atherosclerosis and restenosis Co-applicant with Dr. B. Pittet-Cuenod (Div. Plastic and Reconstructive Surgery, Geneva University Hospital, Geneva, Switzerland) Improving survival and repair Swiss National SFr 167 000 2002-2005 of ischemic tissue Science Foundation Improving the survival of skin Swiss National SFr 206 250 1998-2001 grafts and skin flaps Science Foundation Co-applicant with Dr. C. Morel (Institut de Physique des Hautes Eneries, Université de Lausanne, Lausanne, Switzerland) Design and construction of a Swiss National SFr 769 982 2001-2003 high resolution PET camera Science Foundation for small animals. Co-applicant with Dr. M.-A. Brundler (Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland) Angiogenesis, a possible Ligue Genevoise SFr 57 000 1998/1999 prognostic marker in Barrett’s contre le Cancer esophagus, Barrett’s dysplasia and adenocarcinoma of the lower esophagus and gastric cardia? Co-applicant with Dr. R. Montesano (Dept. Morphology, University of Geneva Medical Center, Geneva, Switzerland) Molecular mechanisms of Swiss National SFr 750 000 1995-2000 capillary and epithelial Science Foundation morphogenesis Molecular mechanisms of Swiss National SFr 524 000 1992-1995 capillary and epithelial Science Foundation morphogenesis - 31 -
Analyse moléculaire du Société Académique SFr 15 970 1990 processus de néoformation de de Genève vaisseaux sanguins Molecular mechanisms of Swiss National SFr 300 000 1989-1992 angiogenesis in vitro Science Foundation Studies on the molecular Sir Jules Thorn SFr 90 870 1988-1991 mechanisms of the Charitable Overseas neovascularization process Trust (angiogenesis) Mechanisms and regulation of Juvenile Diabetes $ 79 950 1988-1989 blood capillary proliferation Foundation in diabetes: an in vitro International approach Analyse moléculaire du Bal de Genève en SFr 49 000 1988 processus de faveur de la Recherche néovascularisation des sur le Cancer tumeurs
- 32 -
MICHAEL PEPPER THESES
PhD Thesis
Faculty of Science, University of Geneva, 1990. "Invasive properties of endothelial cells: contributions to the process of angiogenesis." Thesis no. 2421, 150 pages.
MD Thesis
Faculty of Medicine, University of Geneva, 1992. "Angiogenesis in vitro: interactions between angiogenesis-modulating cytokines and the role of balanced extracellular proteolysis." Thesis no. 9398, 120 pages.
Privat Docent Thesis
Faculty of Medicine, University of Geneva, 1997. "Positive and negative regulation of angiogenesis: from cell biology to the clinic." 203 pages.
- 33 -
PUBLICATIONS
Original Publications (peer review journals)
Total impact factor: 733.461 Number of publications: 150 (7 without IF) Mean impact factor per publication: 5.129 (As of March 2019)
No. Authors Title Journal Impact Factor 1 Montesano R., Pepper M.S., Phorbol ester induces cultured J. Cell. Physiol. 3.923 Vassalli J.-D. and Orci L. endothelial cells to invade a fibrin 132: 509-516 (1987). matrix in the presence of fibrinolytic inhibitors. 2 Pepper M.S., Vassalli J.-D., Urokinase-type plasminogen J. Cell Biol. 8.784 Montesano R. and Orci L. activator is induced in migrating 105: 2535-2541 capillary endothelial cells. (1987). 3 Montesano R., Pepper M.S., Induction of angiogenesis in vitro J. Cell. Physiol. 3.923 Belin D., Vassalli J.-D. and by vanadate, an inhibitor of 134: 460-466 (1988). Orci L. phosphotyrosine phosphatases. 4 Pepper M.S., Spray D.C., Junctional communication is J. Cell Biol. 8.784 Chanson M., Montesano R., induced in migrating capillary 109: 3027-3038 Orci L. and Meda P. endothelial cells. (1989). 5 Pepper M.S., Belin D., Transforming growth factor-beta 1 J. Cell Biol. 8.784 Montesano R., Orci L. and modulates basic fibroblast growth 111: 743-755 (1990). Vassalli J.-D. factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. 6 Montesano R., Pepper M.S., Increased proteolytic activity is Cell 31.398 Möhle-Steinlein U., Risau responsible for the aberrant 62: 435-445 (1990). W., Wagner E.F. and Orci L. morphogenetic behaviour of endothelial cells expressing the middle T oncogene. 7 Meda P., Chanson M., In vivo modulation of connexin 43 Exp. Cell Res. 3.309 Pepper M., Giordano E., gene expression and junctional 192: 469-480 (1991). Bosco D., Traub O., coupling of pancreatic B-cells. Willecke K., El Aoumari A., Gros D., Beyer E.C., Orci L. and Spray D.C. 8 Pepper M.S., Montesano R., Chondrocytes inhibit endothelial J. Cell. Physiol. 3.923 Vassalli J.-D. and Orci L. sprout formation in vitro: evidence 146: 170-179 (1991). for involvement of a transforming growth factor-beta. 9 Pepper M.S., Montesano R., Plasminogen activator inhibitor-1 is Biochem. Biophys. 2.559 Orci L. and Vassalli J.-D. induced in microvascular Res. Commun. endothelial cells by a chondrocyte- 176: 633-638 (1991). derived transforming growth factor- beta. 10 Pepper M.S., Ferrara N., Vascular endothelial growth factor Biochem. Biophys. 2.559 Orci L. and Montesano R. (VEGF) induces plasminogen Res. Commun. activators and plasminogen 181: 902-906 (1991). activator inhibitor-1 in microvascular endothelial cells. 11 Pepper M.S., Montesano R., Coupling and connexin 43 Am. J. Physiol. 3.454 El Aoumari A., Gros D., Orci expression in microvascular and 262 (Cell Physiol. 31): - 34 -
L. and Meda P. large vessel endothelial cells. C1246-C1257 (1992). 12 Pepper M.S., Matsumoto K., Hepatocyte growth factor increases J. Biol. Chem. 4.010 Nakamura T., Orci L. and urokinase-type plasminogen 267: 20493-20496 Montesano R. activator (u-PA) and u-PA receptor (1992). expression in Madin-Darby canine kidney epithelial cells. 13 Pepper M.S., Sappino A.-P., Plasminogen activator inhibitor-1 is J. Cell. Physiol. 3.923 Montesano R., Orci L. and induced in migrating endothelial 153: 129-139 (1992). Vassalli J.-D. cells. 14 Pepper M.S. and Meda P. Basic fibroblast growth factor J. Cell. Physiol. 3.923 increases junctional communication 153: 196-205 (1992). and connexin 43 expression in microvascular endothelial cells. 15 Pepper M.S., Ferrara N., Potent synergism between vascular Biochem. Biophys. 2.559 Orci L. and Montesano R. endothelial growth factor and basic Res. Commun. fibroblast growth factor in the 189: 824-831 (1992). induction of angiogenesis in vitro. 16 Pepper M.S., Vassalli J.-D., Biphasic effect of TGF1 on in Exp. Cell Res. 3.309 Orci L. and Montesano R. vitro angiogenesis. 204: 356-363 (1993). 17 Fotsis T., Pepper M., Genistein, a dietary-derived Proc. Natl. Acad. Sci. 9.504 Aldercreutz H., Fleischmann inhibitor of in vitro angiogenesis. USA G., Hase T., Montesano R. 90: 2690-2694 (1993). and Schweigerer L. 18 Pepper M.S., Sappino A.-P., Upregulation of urokinase receptor J. Cell Biol. 8.784 Stocklin R., Montesano R., expression on migrating endothelial 122: 673-684 (1993). Orci L. and Vassalli J.-D. cells. 19 Montesano R., Pepper M.S. Paracrine induction of angiogenesis J. Cell Sci. 4.401 and Orci L. in vitro by Swiss 3T3 fibroblasts. 105: 1013-1024 (1993). 20 Meda P., Pepper M.S., Traub Differential expression of gap Endocrinology 3.961 O., Willecke K., Gros D., junction connexins in endocrine 133: 2371-2378 Beyer E., Nicholson B., Paul and exocrine glands. (1993). D. and Orci L. 21 Pepper M.S., Wasi S., In vitro angiogenic and proteolytic Exp. Cell Res. 3.309 Ferrara N., Orci. L and properties of bovine lymphatic 210: 298-305 (1994). Montesano R. endothelial cells. 22 Fotsis T., Zhang Y., Pepper The endogenous estrogen Nature 41.577 M.S., Aldercreutz H., metabolite 2-methoxyestradiol 368: 237-239 (1994). Montesano R. Nawroth P.P. inhibits angiogenesis and and L. Schweigerer. suppresses tumor growth. 23 Pepper M.S., Vassalli J.-D., Modulation of bovine J. Cell. Biochem. 2.959 Wilks J.W., Schweigerer L., microvascular endothelial cell 55: 419-434 (1994). Orci. L and Montesano R. proteolytic properties by inhibitors of angiogenesis. 24 Pepper M.S., Ferrara N., Leukemia inhibitory factor (LIF) J. Cell Sci. 4.401 Orci L. and Montesano R. inhibits in vitro angiogenesis. 108: 73-83 (1995). 25 Soriano, J.V., Pepper M.S., Hepatocyte growth factor J. Cell Sci. 4.401 Nakamura T., Orci. L and stimulates extensive development 108: 413-430 (1995). Montesano R. of branching duct-like structures by cloned mammary gland epithelial cells. 26 Mandriota S.J., Seghezzi G., Vascular endothelial growth factor J. Biol. Chem. 4.010 Vassalli J.-D., Ferrara N., increases urokinase receptor 270: 9709-9716 Wasi S., Mazzieri R., expression in vascular endothelial (1995). Mignatti P. and Pepper M.S. cells. 27 Pepper M.S., Soriano J.V., Modulation of hepatocyte growth Exp. Cell Res. 3.309 - 35 -
Menoud P.-A., Sappino A.- factor and c-met expression in the 219: 204-210 (1995). P., Orci, L. and Montesano rat mammary gland during R. pregnancy, lactation and involution. 28 Mandriota S.J., Menoud P.- Transforming growth factor 1 J. Biol. Chem. 4.010 A. and Pepper M.S. down-regulates vascular 271: 11500-11505 endothelial growth factor receptor- (1996). 2/flk-1 expression in vascular endothelial cells. 29 Montesano R., Kumar S., Synergistic effect of hyaluronan Lab. Invest. 4.254 Orci L., and Pepper M.S. oligosaccharides and vascular 75: 249-262 (1996). endothelial growth factor on angiogenesis in vitro. 30 French L.E., Soriano J.V., Modulation of clusterin gene Biol. Reprod. 3.184 Montesano R. and Pepper expression in the rat mammary 55: 1213-1220 (1996). M.S. gland during pregnancy, lactation and involution. 31 Zimrin A.B., Pepper M.S., An antisense oligonucleotide to the J. Biol. Chem. 4.010 McMahon G.A., Nguyen F., notch ligand Jagged enhances 271: 32499-32502 Montesano R., Maciag T. fibroblast growth factor-induced (1996). angiogenesis in vitro. 32 Thommen R., Humar R., PDGF-BB increases endothelial J. Cell. Biochem. 2.959 Misevic G., Pepper M.S., migration and cord movements 64: 403-413 (1997). Hahn A.W.A., John M. and during angiogenesis in vitro. Battegay E.J. 33 Gorden, D.L., Mandriota Vascular endothelial growth factor Transplantation 3.960 S.J., Montesano R., Orci L. is increased in devascularized rat 63: 436-443 (1997). and Pepper M.S. islets of Langerhans in vitro. 34 Anande-Apte B., Pepper Inhibition of angiogenesis by tissue Invest. Ophth. Vis. 3.388 M.S., Voest E., Montesano inhibitor of metalloproteinase-3 Sci. 38: 817-823 R., Olsen B., Murphy G., (TIMP-3). (1997). Apte S.S. and Zetter B. Anande-Apte B., Pepper Untitled - reply Invest. Ophth. Vis. 3.388 M.S., Voest E., Montesano Sci. 38: 2433-2434 R., Olsen B., Murphy G., (1997). Apte S.S. and Zetter B. 35 Sabapathy K.T., Pepper Polyoma middle T-induced J. Cell Biol. 8.784 M.S., Kiefer F., Möhle- vascular tumor formation: the role 137: 953-963 (1997). Steinlein U., Tacchini- of the plasminogen Cottier F., Fetka I., Breier G., activator/plasmin system. Risau W., Montesano R. and Wagner E.F. 36 Fotsis T., Pepper M.S., Aktas Flavonoids, dietary-derived Cancer Res. 10.199 E., Breit S., Rasku S., inhibitors of cell proliferation and 57: 2916-2921 (1997). Adlercreutz H., Wähälä K., in vitro angiogenesis. Montesano R. and Schweigerer L. 37 Masouyé I., Hagens G., Van Endothelial cells of the human Circ. Res. 15.211 Kuppevelt T.H., Madsen P., microvasculature express epidermal 81: 297-303 (1997). Saurat J.-H., Veerkamp J.H., fatty acid-binding protein. Pepper M.S. and Siegenthaler G. 38 Mandriota S.J. and Pepper Vascular endothelial growth factor- J. Cell Sci. 4.401 M.S. induced in vitro angiogenesis and 110: 2293-2302 plasminogen activator expression (1997). are dependent on endogenous basic fibroblast growth factor. - 36 -
39 Terris B., Scoazec J.-Y., Expression of vascular endothelial Histopathology. 3.267 Rubbia L., Bregeaud L., growth factor in digestive 32:133-138 (1998). Pepper M.S., Ruszniewski neuroendocrine tumors. P., Belghiti J., Fléjou J.-F. and Degott C. 40 Bochaton-Piallat M.-L., Plasminogen activator expression Circ. Res. 15.211 Gabbiani G. and Pepper M.S. in rat arterial smooth muscle cells 82: 1086-1093 (1998). depends on their phenotype and is modulated by cytokines. 41 Pepper M.S. and Mandriota Regulation of vascular endothelial Exp. Cell Res. 3.309 S.J. growth factor receptor-2 (Flk-1) 241: 414-425 (1998). expression in vascular endothelial cells. 42 Cavallaro U., Wu Z.-H., Di Fibroblast growth factor-2 FASEB J. 5.595 Palo A., Montesano R., stimulates migration of Kaposi’s 12: 1027-1034 (1998). Pepper M.S., Maier J.A.M. sarcoma-like vascular spindle cells and Soria M.R. by HGF-dependent relocalization of the urokinase receptor. 43 Mandriota S.J. and Pepper Regulation of angiopoietin-2 Circ. Res. 15.211 M.S. mRNA levels in bovine 83: 852-859 (1998). microvascular endothelial cells by cytokines and hypoxia. 44 Olofsson B., Korpelainen E., VEGF-B binds to VEGFR-1 and Proc. Natl. Acad. Sci. 9.504 Pepper M.S., Mandriota S.J., regulates plasminogen activator USA. 95: 11709- Aase K., Kumar V., Gunji activity in endothelial cells. 11714 (1998). Y., Jeltsch M.., Shibuya M., Alitalo K. and Eriksson U. 45 Pepper M.S., Mandriota S.J., Vascular endothelial growth factor J. Cell. Physiol. 3.923 Jeltsch M. Kumar V. and (VEGF)-C synergizes with basic 177: 439-452 (1998). Alitalo K. fibroblast growth factor and VEGF in the induction of angiogenesis in vitro, and alters endothelial cell extracellular proteolytic activity. 46 Lucas R., Garcia I., Donati Specific role of TNF receptor 2 in Eur. J. Immunol. 28: 4.248 Y.R.A., Hribar M., direct, but not in sensitized TNF- 3577-3586 (1998). Mandriota S.J., Giroud C., mediated cytotoxicity in Buurman W.A., Fransen L., microvascular endothelial cells. Suter P.M., Nuñez G., Pepper M.S. and Grau G.E. 47 Lucas R., Holmgren L., Multiple forms of angiostatin Blood 15.132 Garcia I., Jiminez, B., induce apoptosis in endothelial 92: 4730-4741 (1998). Mandriota S.J., Borlat F., cells. Sim B.K.L., Wu Z., Grau G.E., Shing Y., Soff G.A., Bouck N. and Pepper M.S. 48 Collo G. and Pepper M.S. Endothelial cell integrin 51 J. Cell Sci. 4.401 expression is modulated by 112: 569-578 (1999). cytokines and during migration in vitro. 49 Montesano R., Soriano J.V., Constitutively active MAPK kinase Cell Growth Differ. Hosseini G., Pepper M.S. MEK1 disrupts morphogenesis and 10: 317-332 (1999). and Schramek H. induces an invasive phenotype in MDCK epithelial cells. 50 Neuville P., Yan Z., Gidlöf Retinoic acid regulates arterial Arterioscl. Thromb. 6.086 A., Pepper M.S., Hansson smooth muscle cell proliferation Vasc. Biol. G.K., Gabbiani G. and Sirsjö and phenotypic features in vivo and 19: 1430-1436 (1999). - 37 -
A. in vitro through a RAR- independent-signalling pathway. 51 Soriano J.V., Pepper M.S., Chromogranin A increases Biochem. Biophys. 2.559 Taupenot L., Bader M.-F., deposition of basement membrane Res. Commun. Orci L. and Montesano R. components by mammary epithelial 259: 563-568 (1999). cells. 52 Miralbell R., Tolnay M., Pediatric medulloblastoma: J. Neuro-oncol. 3.060 Bieri S., Probst A., Sappino prognostic value of p53, bcl-2, 45: 103-110 (1999). A.-P., Berchtold W., Pepper Mib-1, and microvessel density. M.S. and Pizzolato G.: 53 Zhao H., Bojanowski K., A new role for tRNA and its J. Cell. Biochem. 2.959 Ingber D.E., Panigrahy D., fragment purified from urinary 76: 109-117 (2000). Pepper M.S., Montesano R. bladder carcinoma conditioned and Shing Y. medium: inhibition of endothelial cell growth. 54 Fuhrmann-Benzakein E., Ma Elevated levels of angiogenic Int. J. Cancer. 7.360 M.N., Rubbia-Brandt L., cytokines in the plasma of cancer 85: 40-45 (2000). Mentha G., Rufenacht D., patients. Sappino A.-P. and Pepper M.S. 55 Tenan M., Fulci G., Thrombospondin-1 is J. Exp. Med. 10.790 Albertoni M., Diserens A.- downregulated by anoxia and 191: 1789-1798 C., Hamou M.-F., El Atifi- suppresses tumorigenicity of (2000). Borel M., Feige J.-J., Pepper human glioblastoma cells. M.S. and van Meir E.G. 56 Mandriota S.J., Pyke C., Di Hypoxia-inducible angiopoietin-2 Am. J. Pathol. 4.069 Sanza C., Quinodoz P., Pittet expression is mimicked by 156: 2077-2089 B. and Pepper M.S. diphenylene iodonium and occurs (2000). in the rat brain and skin in response to systemic hypoxia and tissue ischemia. 57 Pepper M.S., Baetens D., Regulation of VEGF and VEGF Dev. Dynam. 2.507 Mandriota S.J., Di Sanza C., receptor expression in the rodent 218: 507-524 (2000). Oikemus S., Lane T.F., mammary gland during pregnancy, Soriano J.V., Montesano R. lactation and involution. and Iruela-Arispe M.L. 58 Taraboletti G., Sonzogni L., Post-transcritpional stimulation of Exp. Cell Res. 3.309 Vergani V., Hosseini G., endothelial cell matrix 258: 384-394 (2000). Ceruti R., Ghilardi C., metalloproteinases 2 and 1 by Bastone A., Toschi E., endothelioma cells. Borsotti P., Scanziani E., Giavazzi R., Pepper M.S., Stetler-Stevenson W. and Bani M.R. 59 Cavallaro U., Castelli V., Characterization of novel clonal In Vitro Cell. Dev. 1.447 Perilli A., Dossi R., Giavazzi murine endothelial cell lines with An. R., Pepper M.S., Soria M.R. an extended life span. 36: 299-308 (2000). and Montesano R. 60 Fuhrmann-Benzakein E., Cre-mediated inducible and Nucleic Acids. Res. 11.561 Garcia-Gabay I., Pepper irreversible control of gene 28: e99 (5 pages) M.S., Vassalli J.-D. and expression using a single transgene. (2000). Herrera P.L. 61 Scheidegger P., Weiglhofer Signalling properties of an HIV- Biochem. J. 3.857 W., Suarez S., Console S., encoded angiogenic peptide 353: 569-578 (2001). Waltenberger J., Pepper mimicking vascular endothelial M.S., Jaussi R. and Ballmer- growth factor activity. - 38 -
Hofer K. 62 Mandriota S.J., Jussila L., Vascular endothelial growth factor- EMBO J. 10.557 Jeltsch M., Compagni A., C-mediated lymphangiogenesis 20: 672-682 (2001). Baetens D., Prevo R., Banerji promotes tumour metastasis. S., Huarte J., Montesano R., Jackson D., Orci L., Alitalo K., Christofori G. and Pepper M.S. 63 Lucas R., Montesano R., Lectin-deficient TNF mutants Int. J. Cancer 7.36 Pepper M.S., Hafner M., display comparable anti-tumor but 91: 543-549 (2001). Sablon E., Dunant Y., Grau reduced pro-metastatic potential as G.E., De Baetselier P., compared to the wild-type Männel D. and Fransen L. molecule. 64 Cavallaro U., Perilli A., FGF-2 promotes disassembly of Microvasc. Res. 2.465 Castelli V., Pepper M.S. and actin cytoskeleton and shape 61: 211-214 (2001). Soria M.R. changes in murine vascular cells. 65 Kwak B.R., Pepper M.S., Inhibition of endothelial wound Mol. Biol. Cell 3.512 Gros D.B. and Meda P. repair by dominant negative 12: 831-845 (2001). connexin inhibitors. 66 Rinsch C., Quinodoz P., Delivery of FGF-2 but not VEGF Gene Ther. 3.203 Pittet B., Alizadeh N., by encapsulated genetically 8: 523-533 (2001). Baetens D., Montadon D., engineered myoblasts improves Aebischer P. and Pepper survival and vascularization in a M.S. model of acute skin flap ischemia. 67 Pepper M.S., Rosnoblet C., Synergistic induction of tissue-type Thromb. 4.952 Di Sanza C. and Kruithof plasminogen activator (tPA) by Haemostasis E.K.O. vascular endothelial growth factor 86: 702-709 (2001). and basic fibroblast growth factor and localization of tPA to Weibel- Palade bodies in bovine microvascular endothelial cells. 68 Cavallaro U., Tenan M., The response of bovine endothelial J. Cell. Biochem. 2.959 Castelli V., Perilli A, cells to FGF-2 and VEGF is 82: 619-633 (2001). Maggiano N., Van Meir E., dependent on their site of origin: Montesano R., Soria M.R., relevance to the regulation of and Pepper M.S. angiogenesis. 69 Kirkin V., Mazitschek R., Characterisation of indolinones Eur. J. Biochem. 268: 4.53 Krishnan J., Steffen A., which preferentially inhibit VEGF- 5530-5540 (2001). Waltenberger J., Pepper C- and VEGF-D-induced activation M.S., Giannis A. and of VEGFR-3 rather than VEGFR-2. Sleeman J.P. 70 Tille J.-C., Wood J., Vascular endothelial growth factor J. Pharmacol. Exp. 3.706 Mandriota S.J., Schnell C., (VEGF) receptor-2 antagonists Ther. Ferrari S., Mestan J., Zhu Z., inhibit VEGF- and basic fibroblast 299: 1073-1085 Witte L. and Pepper M.S. growth factor-induced angiogenesis (2001). in vivo and in vitro. 71 Gannon G., Mandriota S.J., Overexpression of VEGF-A165 Cancer Res. 10.199 Cui L., Baetens D., Pepper enhances tumor angiogenesis but 62: 603-608 (2002). M.S. and Christofori G. not metastasis during -cell carcinogenesis. 72 Lucas R., Lijnen H.R., Increased angiostatin levels in Thromb. 4.952 Suffredini A.F., Pepper M.S., bronchoalveolar lavage fluids from Haemostasis Steinberg K.P., Martin T.R. ARDS patients and from human 87: 966-971 (2002). and Pugin J. volunteers after lung instillation of endotoxin. 73 Hao H., Ropraz P., Verin V., Heterogeniety of smooth muscle Arterioscl. Thromb. 6.086 - 39 -
Camenzind E., Geinoz A., cell populations cultured from pig Vasc. Biol. Pepper M.S., Gabbiani G. coronary artery. 22: 1093-1099 (2002). and Bochaton-Piallat M.L. 74 Van Trappen P.O., Ryan A., A model for co-expression pattern Brit. J. Cancer 5.922 Carroll M., Lecoeur C., Goff analysis of genes implicated in 87: 537-544 (2002). L., Gyselman V.G., Young angiogenesis and tumour cell B.D., Lowe D.G., Pepper invasion in cervical cancer. M.S., Shepherd J.H. and Jacobs I.J. 75 Tille J.C. and Pepper M.S. Mesenchymal cells potentiate Exp. Cell Res. 3.309 vascular endothelial growth factor- 280: 179-191 (2002). induced angiogenesis in vitro. 76 Podgrabinska S., Braun P., Molecular characterization of Proc. Natl. Acad. Sci. 9.504 Velasco P., Kloos B., Pepper lymphatic endothelial cells. USA M.S. and Skobe M. 99: 16069-16074 (2002). Podgrabinska S., Braun P., Correction Proc. Natl. Acad. Sci. 9.504 Velasco P., Kloos B., Pepper USA M.S. and Skobe M. 100: 4970 (2003). 77 Tille J.C., Wang X., Lipson Vascular endothelial growth factor Exp. Cell Res. 3.309 K.E., McMahon G., Ferrara (VEGF) receptor-2 signaling 285: 286-298 (2003). N., Zhu Z., Hicklin D.J., mediates VEGF-CΔNΔC- and VEGF- Sleeman J.P., Eriksson U., A-induced angiogenesis in vitro. Alitalo K. and Pepper M.S. 78 Tille J.C., Morris M.A., Familial predisposition to tufted Clin. Genet. 3.512 Bründler M.A and Pepper angioma – identification of blood 63: 393-399 (2003). M.S. and lymphatic vascular components. 79 Wernert N., Okuducu A.F. Ets 1 is expressed in capillary J. Pathol. 6.253 and Pepper M.S. blood vessels but not in lymphatics. 200: 561-567 (2003). 80 Van Trappen P.O., Steele D., Expression of vascular endothelial J. Pathol. 6.253 Lowe D.G., Baithun S., growth factor (VEGF)-C and 201: 544-554 (2003). Beasley N., Thiele W., VEGF-D, and their receptor Weich H., Krishnan J., VEGFR-3, during different stages Shepherd J.H., Pepper M.S., of cervical carcinogenesis. Jackson D.G, Sleeman J.P. and Jacobs I.J. 81 Nisato R.E., Tille J.C., v3 and v5 integrin Angiogenesis 4.351 Jonczyk A., Goodman S.L. antagonists inhibit angiogenesis in 6: 105-119 (2003). and Pepper M.S. vitro. 82 Zhang H., Vutskits L., VEGF is a chemoattractant for J. Cell Biol. 8.784 Pepper M.S. and Kiss J.Z. FGF-2 stimulated neural 163: 1375-1384 progenitors. (2003). 83 Pepper M.S., Hazel S.J., 8-Prenylnaringenin, a novel J. Cell Physiol. 3.923 Hümpel M. and Schleuning phytoestrogen, inhibits 199: 98-107 (2004). W.-D. angiogenesis in vitro and in vivo. 84 Persaud K., Tille J.C., Liu Involvement of the VEGF receptor- J. Cell Sci. 4.401 M., Zhu Z., Jimenez X., 3 in capillary morphogenesis 117: 2745-2756 Peirera D., Miao H.Q., Witte demonstrated with a human anti- (2004). L., Pepper M.S. and human VEGFR-3 antibody that Pytowski B. antagonizes receptor activation by VEGF-C. 85 Aurrand-Lions M., Johnson- Hemangiomas are formed by cells J. Pathol. 6.253 Leger C., Pepper M.S. and expressing high levels of integrin 203: 700-709 (2004).
Imhof B.A. v3 and lacking acetylated-LDL uptake. - 40 -
86 Nisato R.E., Harrison J.A., Generation and characterization of Am. J. Pathol. 4.069 Buser R., Orci L., Rinsch C., telomerase-transfected human 165: 11-24 (2004). Montesano R., Dupraz P., lymphatic endothelial cells with an Pepper M.S. extended lifespan. 87 Rubbia-Brandt L., Terris B., Lymphatic vessel density and Clin. Cancer Res. 10.199 Giostra E., Dousset B., VEGF-C expression correlate with 10: 6919-6928 (2004). Morel P. and Pepper M.S. malignant behavior in human pancreatic endocrine tumors. 88 Alizadeh N., Pittet B., Pyke Active-site inactivated FVIIa J. Surg. Res. 2.051 C., Baetens D., Montandon (FVIIai) increases survival in a 122: 263-273 (2004). D., Ezban M. and Pepper random skin flap model of acute M.S. ischemia. 89 Kiriakidis S., Högemeier O., Novel tempeh (fermented Brit. J. Nutr. 3.657 Starcke S., Dombrowski F., soyabean) isoflavones inhibit in 93: 317-323 (2005). Hahne J.C., Pepper M., Jha vivo angiogenesis in the chicken H.C. and Wernert N. chorioallantoic membrane assay. 90 Soulié P., Carrozzino F., Membrane-type-1 matrix Oncogene 6.854 Pepper M.S., Strongin A.Y., metalloproteinase confers 24:1689-1697 (2005). Poupon M.-F. and tumorigenicity on non-malignant Montesano R. epithelial cells. 91 Zanetta L., Corada M., Downregulation of vascular Thromb. 4.952 Lampugnani M., Zanetti A., endothelial-cadherin expression is Haemostasis Breviario F., Moons L., associated with an increase in 93: 1041-1046 (2005). Carmeliet P., Pepper M.S., vascular tumor growth and and Dejana E. hemorrhagic complications. 92 Nisato R.E., Hosseini G., Dissecting the role of matrix Cancer Res. 10.199 Sirrenberg C., Butler G.S., metalloproteinases (MMP) and 65: 9377-9387 (2005). Crabbe T., Docherty A.J.P., integrin v3 in angiogenesis in Wiesner M., Murphy G., vitro: absence of hemopexin C Overall C.M., Goodman S.L. domain bioactivity, but membrane- and Pepper M.S. type 1-MMP and v3 are critical. 93 Brundler M.A., Harrison Lymphatic vessel density in the J. Clin. Pathol. 2.894 J.A., de Saussure B., de neoplastic progression of Barrett 59:191-195 (2006). Perrot M., Pepper M.S. oesophagus to adenocarcinoma. 94 Buser R., Montesano R., Bovine microvascular endothelial J. Cell. Biochem. 2.959 Garcia I., Dupraz P. and cells immortalized with human 98: 267-286 (2006). Pepper M.S. telomerase. 95 Jenny B., Harrison J.A., Expression and localization of J. Pathol. 6.253 Baetens D., Tille J.C., VEGF-C and VEGFR-3 in 209: 34-43 (2006). Burkhardt K., Mottaz H., glioblastomas and Kiss J.Z., Dietrich P.Y., De hemangioblastomas. Tribolet N., Pizzolato G.P., Pepper M.S. 96 Friedrichs N., Hahne J.C., Immunohistochemical Histopathology 3.267 Pepper M.S., quantification of lymph vessels, 49: 87-88 (2006). Rommerscheidt-Fuss U., VEGF-C and VEGF receptor 3 in Stelzner F., Buettner R. and human sarcomas. Wernert N. 97 Mahajan A.L., Tenorio X., Progressive tissue injury in burns is Burns 2.134 Pepper M.S., Baetens D., reduced by rNAPc2. 32: 957-963 (2006). Montandon D., Schlaudraff K.U., Pittet B. 98 Mathe Z., Dupraz P., Rinsch Tetracycline-regulated expression Cell Transplantation: 2.885 C., Thorens B., Bosco D., of VEGF-A in beta-cells induces 15: 621-636 (2006). Zbinden M., Morel P., angiogenesis: improvement of Berney T. and Pepper M.S. engraftment following - 41 -
transplantation. 99 Alizadeh N., Pepper M.S., Persistent ischemia impairs Wound Rep. Reg. 2.952 Modarressi A., Alfo K., myofibroblast development in 15: 809-816 (2007). Schlaudraff K., Montandon wound granulation tissue. A new D., Gabbiani G., Bochaton- model of delayed wound healing. Piallat M.L. and Pittet B. 100 Schlaudraff K.U., Bezzola Mixed arterio-venous insufficiency J. Surg. Res. 2.051 T., Montandon D., Pepper in random skin flaps in the rat: is 150: 85-91 (2008). M.S., Pittet B. the application of medicinal leeches beneficial? 101 Schlaudraff K.U., Pepper Hypoxic preconditioning increases High Alt. Med. Biol. 1.854 M.S., Tkatchouk E.N., skin oxygenation and viability but 9: 76-88 (2008). Ehrenburg I., Alizadeh N., does not alter VEGF expression or Montandon D., Pittet B. vascular density. 102 Pegu A., Qin S., Fallert Human lymphatic endothelial cells J. Immunol. 4.539 Junecko B.A., Nisato R.E., express multiple functional TLRs. 180: 3399-3405 Pepper M.S., Reinhart T.A. (2008). 103 Mabeta P. and Pepper M.S. A comparative study on the anti- Angiogenesis 4.351 angiogenic effects of DNA- 12: 81-90 (2009). damaging and cytoskeletal- disrupting agents. 104 Hammer T., Tritsaris K., IL-20 activates human lymphatic Microvasc. Res. 2.465 Hübschmann M.V., Pepper endothelial cells causing cell 78: 25-32 (2009). M.S., Nisato R.N. and signalling and tube formation. Dissing S. 105 Jordaan D.W., Woodrow C. Banning private umbilical cord S. Afr. J. Hum. 0.490 and Pepper M.S. blood banks: a human rights Rights analysis. 25: 126-151 (2009).
106 Flister M.J., Wilber A., Hall Inflammation induces Blood 15.132 K.L, Iwata C., Miyazono K., lymphangiogenesis through 115: 418-429 (2010). Nisato R., Pepper M.S., upregulation of VEGFR-3 mediated Zawieja D.C. and Ran S. by NF-B and Prox1. 107 Slabbert M.N. and Pepper “A room of our own?” Legal Tydskrif vir M.S. lacunae regarding genomic Hedendaagse sovereignty in South Africa. Romeins-Hollandse Reg (J. Contemporary South African Roman- Dutch Law) 73: 432-450 (2010). 108 Dodgen T.M., Cromarty Quantitative plasma analysis using J. Separation 2.415 A.D. and Pepper M.S. automated online solid-phase Science. extraction with column switching 34: 1102-1110 (2011). LC-MS/MS for characterising cytochrome P450 2D6 and 2C19 metabolism. 109 Pepper M.S. and Slabbert Is South Africa on the verge of a S. Afr. J. Bioethics 0.380 M.N. medical malpractice litigation Law storm? 4: 29-35 (2011). 110 Slabbert M.N., Maister B., The application of the Consumer Comp. Int. Law J. Botes M. and Pepper M.S. Protection Act in the South African Southern Afr. health care context: concerns and (CILSA). recommendations. 94: 168-203 (2011). 111 Ammar A., Mohammed Lymphatic expression of CLEVER- Anal. Cell Pathol. 1.574 R.A.A., Salmi M., Pepper 1 in breast cancer and its 34: 67-78 (2011) - 42 -
M., Paish E.C., Ellis I.O. and relationship with lymph node Martin S.G. metastasis. 112 Mabeta P. and Pepper M.S. Inhibition of hemangioma Angiogenesis 4.351 development in a syngeneic mouse 15: 131-139 (2012). model correlates with bcl-2 suppression and the inhibition of Akt kinase activity. 113 de Vries J., Slabbert M.N. Ethical, legal and social issues in Med. Law J. and Pepper M.S. the context of the planning stages 31:119-152 (2012). of the Southern African Human Genome Programme. 114 de Vries J. and Pepper M. Genomic sovereignty and the J. Med. Ethics 1.889 African promise: mining the 38: 474-478 (2012). African genome for the benefit of Africa. 115 Meissner-Roloff M., Young Pilot social feasibility study for the Stem Cell Rev. Rep. 3.612 W.M., Rangaka I., Lombaard establishment of a public human 8: 1066-1075 (2012). H., Dhai A., Tsotsi N. and umbilical cord blood stem cell bank Pepper M.S. in South Africa. 116 Alessandrini M., Klose K. Technology transfer practices at Innovation: and Pepper M.S. South African universities and Management, Policy science councils. and Practice 15: 207-216 (2013). 117 Dodgen T.M., Hochfeld Introduction of the AmpliChip BMC Med. Genet. 1.913 W.E., Fickl H., Asfaha S.M., CYP450 Test to a South African 14:20 (2013). Durandt C., Rheeder P., cohort: a platform comparative Drögemöller B.I., Wright prospective cohort study. G.E.B., Warnich L., Labuschagne D. de J., van Schalkwyk A., Gaedigk A. and Pepper M.S. 118 Mahomed S., Slabbert M.N. The legal position of the S. Afr. J. Bioethics 0.380 and Pepper M.S. classification of human tissue in Law South Africa – can tissues be 6: 16-20 (2013). owned? 119 Nielsen S.R., Hammer T., IL-27 inhibits lymphatic Microcirculation 2.797 Gibson J., Pepper M.S., endothelial cell proliferation by 20: 555-564 (2013). Nisato R.E., Dissing S. and STAT1-regulated gene expression. Tritsaris K. 120 Barmania F., Potgieter M. Mutations in C-C chemokine Int. J. Infect. Dis. 3.202 and Pepper M.S. receptor type five (CCR5) in South 17: e1148–e1153 African individuals. (2013). 121 Meissner-Roloff and Pepper Establishing a public umbilical Stem Cell Rev. Rep. 3.612 M.S. cord blood stem cell bank (UCB 9: 752–763 (2013). SCB) for South Africa: an enquiry into public acceptability.
122 Grant C.C., Janse van The correlation between the health- S. Afr. Family Rensburg D.C., Pepper M.S., related fitness of healthy Practice. du Toit P.J., Wood P.S., Ker participants measured at home 56: 235-239 (2014). J., Krüger P.E., Grobbelaar opposed to fitness measured by C.W., Nolte K., Fletcher L. sport scientists in a laboratory. and Grant T.C. 123 Taylor J., Anyango J.O., Biocompatibility and J. Biomed. Mater. 3.231 Potgieter M., Kallmeyer K., biodegradation of protein Res. Part A: - 43 -
Naidoo V., Pepper M.S and microparticle and film scaffolds 103A: 2582–2590 Taylor J.R.N. made from kafirin (sorghum (2015). prolamin protein) subcutaneously implanted in rodent models. 124 Mabeta P. and Pepper M.S. Altered expression of platelet Biomedicine & 3.457 factor 4 and basic fibroblast growth Pharmacotherapy factor correlates with the inhibition 69: 186-190 (2015). of tumor growth in mice. 125 Mellet J., Alessandrini M., Constituting a public umbilical Bone Marrow 4.497 Steel H.C and Pepper M.S. cord blood bank in South Africa. Transplantation. 50: 615-616 (2015). 126 Myburgh R., Ivic S., Pepper Lentivector knock-down of CCR5 J. Virol. 4.368 M.S, Gers-Huber G., Li D., in hematopoietic stem cells confers 89: 6761-6772 (2015). Audigé A., Rochat M.A, functional and persistent HIV- Jaquet V., Regenass S., resistance in humanized mice. Manz M.G, Salmon P., Krause K.H and Speck R.F 127 Dodgen T.M., Eloff A., Relationship between risperidone- Appl. Translational Mataboge C., Roos J.L., van associated adverse drug reactions Genomics. Staden C.W. and Pepper and CYP2D6 polymorphisms in the 5: 40-46 (2015). M.S. South African population: a pilot study. 128 Dodgen T.M., Drögemöller Evaluation of predictive CYP2C19 Pharmagogenomics. 2.302 B.I., Wright G.E.B, Warnich genotyping assays relative to 16: 1343-1354 (2015). L., Steffens F.E, Cromarty measured phenotype in a South A.D, Alessandrini M. and African cohort. Pepper M.S. 129 Logan M., van der Merwe Melanocortin 4 receptor (MC4R) Mol. Genet. Genomic 2.695 M.T., Dodgen T., Myburg R., polymorphisms in a South African Med. Eloff A., Rheeder P. And study group. 4: 68-76 (2015). Pepper M.S. 130 Mellet J., Gray C.M. and Conventional HLA typing S. Afr. Med. J. 2.163 Pepper M.S. techniques vs. next generation 106: 88-91 (2016). sequencing in a South African cohort. 131 Durandt C., van Vollenstee A novel multi-parameter flow J Lipid Res. 4.505 F., Kallmeyer K., de Villiers cytometric approach for detecting 57: 729–742 (2016). D., Honing C., Potgieter M. adipocyte sub-populations during and Pepper M.S. adipogenesis. 132 Ambele M.A., Dessels C., Genome-wide analysis of gene Stem Cell Res. 1.829 Durandt C. and Pepper M.S. expression during adipogenesis in 16: 725-734 (2016). human adipose-derived mesenchymal stromal cells reveals novel patterns of gene expression during adipocyte differentiation. 133 Dzobo K., Turnley T., Fibroblast-derived extracellular Int. J. Mol. Sci. 3.687 Wishart A., Rowe A., matrix induces chondrogenic 17: 1259 (2016). Kallmeyer K., van differentiation in human Vollenstee F.A., Thomford mesenchymal stromal/stem cells in N.E., Dandara C., Chopera vitro. D., Pepper M.S. Parker M.I. 134 Mahomed S., Slabbert M.N. Social justice and research using S. Afr. Med. J. 2.163 and Pepper M.S. human biological material: A right 106: 841 (2016). to respond. 135 Dzobo K., Vogelsang M., Wharton’s Jelly-derived Stem Cells Int. 3.989 Dandara C., Kallmeyer K., mesenchymal stem cells and 2016: 4842134 (2016). - 44 -
Pepper M.S., Parker M.I. and fibroblast-derived extracellular Thomford N.E. matrix activate apoptosis in a p21- dependent mechanism in WHCO1 and MDA MB 231 cancer cells in vitro. 136 van Vollenstee F.A, Jackson Human adipose derived Cytotechnology. 1.461 C., Hoffmann D., Potgieter mesenchymal stromal cells 68: 2049-2060 (2016). M., Durandt C. and Pepper transduced with GFP lentiviral M.S. vectors: assessment of immunophenotype and differentiation capacity in vitro. 137 Janse van Rensburg D.C., The FitTrack Index as fitness Health SA 0.28 Grant C.C., Jansen van indicator: A pilot study. Gesondheid. Rensburg A., Botha R.P.G., 21: 431-436 (2016). Wood P.S., Nolte K., Fletcher L., du Toit P.J., Pepper M.S. and Kruger P.E. 138 Mahomed S., Slabbert M.N. Ownership and human tissue - the S. Afr. Med. J. 2.163 and Pepper M.S. legal conundrum: A response to 107:196-198 (2017). Jordaan’s critique. 139 Ambele M.A and Pepper Identification of transcription Mol. Genet. Genomic 2.695 M.S. factors potentially involved in Med. human adipogenesis in vitro. 5: 210-222 (2017). 140 Dodgen T.M., Labuschagne Pharmacogenetic comparison of Pharmacogenomics 3.812 C. de J., van Schalkwyk A., CYP2D6 predictive and measured J. Steffens F.E., Gaedigk A., phenotypes in a South African 17: 393 (2017) Cromarty A.D. and Pepper cohort M.S. 141 Choudhry M., Alessandrini Impact of CYP2D6 genotype on Pharmacogenomics. 2.302 M., Rademan J., Dodgen amitriptyline efficacy for the 18: 433-443 (2017). T.M., Steffens F.E, van Zyl treatment of diabetic peripheral D.G, Gaedjik A. and Pepper neuropathy: A pilot study. M.S. 142 Jackson C.S., Durandt C., Targeting the Aryl hydrocarbon Stem Cell Res. 1.829 Janse van Rensburg I., receptor nuclear translocator 21: 124-131 (2017). Praloran V., Brunet de la complex with DMOG and Grange P. and Pepper M.S. Stemregenin 1 improves primitive hematopoietic stem cell expansion. 143 Kappala S., Alessandrini M., Application of the AMLprofiler Stem Cells Int. 3.989 Matlhako T., Beltchev E., microarray diagnostic in the South Article ID 2560191, 8 Pool R., and Pepper M.S. African setting. pages (2017). 144 Choudhury A., Ramsay M., Whole genome sequencing for an Nat. Commun. 12.353 Hazelhurst S., Aron S., enhanced understanding of genetic 8: 2062 (2017). Bardien S., Botha G., variation among South Africans. Chimusa E., Christoffels A., Gamieldien J., Sefid Dashti M.J., Joubert F., Meintjes A., Mulder N., Ramesar R., Rees J., Scholtz K., Sengupta D., Soodyall H., Venter P., Warnich L. and Pepper M.S. 145 Naidoo A., Ramsuran V., Effect of genetic variation in Pharmacogenomics. 2.302 Chirehwa M., Denti P., UGT1A and ABCB1 on 19: 17-29 (2018). McIlleron H., Naidoo K., moxifloxacin pharmacokinetics in Yende-Zuma N., Singh R., South African tuberculosis patients. Ngapu S., Chaudhry M., - 45 -
Pepper M.S. and Padayatchi N. 146 Dessels C., Durandt C. and Comparison of human platelet Platelets. 2.356 Pepper M.S. lysate alternatives using expired 19: 1-12 (2018). Platelets. 2018 Mar 19:1-12. and freshly isolated platelet concentrates for adipose-derived stromal cell expansion. 147 Tshabalala M., Ingram C., Human Leukocyte Antigen-A, B, J. Immunol. Res. 3.298 Schlaphoff T., Borrill V., C, DRB1, and DQB1 Allele and 23:2031571 (2018). Christoffels A., Pepper M.S. Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry. 148 Stander B.A., van Volenstee An in vitro and in vivo study on the PLoS One 2.766 F., Kallemyer K., Potgieter properties of hollow 13: e0198248 (2018). M., Swanepoel A., Joubert polycaprolactone cell-delivery A., Moolman S., Kotze L., particles. Pepper M.S. 149 Ambele M.A., Pepper M.S., Heterozygosity of p16 expression Head & Neck 2.471 van Heerden M.B. and van in an oral squamous cell carcinoma 2018 Dec 14. doi: Heerden W.F.P. with associated loss of 10.1002/hed.25566. heterozygosity and copy number [Epub ahead of print] alterations. PubMed PMID: 30552721. 150 Du Plessis N.M, Muller An early-infant HIV-risk score for Pediatrics 5.515 C.J.B, Avenant T, Pepper targeted testing of HIV infection at Jun 2019, 143 (6) M.S, Goga A.E. birth: results from the birth cohort e20183834; DOI: of the Very Early Infant Diagnosis 10.1542/peds.2018- of HIV (VEID) study, South 3834 Africa. 151 Haeri Mazanderani A., Non-nucleoside reverse J. Int. AIDS Soc. Murray T., Sherman G.G., transcriptase inhibitor levels among In press (2019). Snyman T., George J., HIV-exposed uninfected infants at Avenant T., Goga A.E., the time of HIV PCR testing – Pepper M. and du Plessis N. findings from a tertiary healthcare facility in Pretoria, South Africa. 152 Skeen M., Eksteen C. and Stem cell tourism and spinal cord S. Afr. Med. J. Pepper M.S.. injury in South Africa. In press (2019).
153 Ambele M.A., Pepper M.S., Molecular profile of tongue cancer Laryngoscope Invest. van Heerden M.B. and van in an 18-year old female patient Otolaryngol. Heerden W.F.P. with no recognizable risk factor. In press (2019) 154 Dessels C. and Pepper M.S. Reference gene expression in Tissue Engineering, adipose-derived stromal cells Part C: Methods. undergoing adipogenic In press (2019). differentiation.
Manuscripts Submitted for Publication
1. Viljoen, J.W., De Villiers, J.P., Van Zyl, A.J., Mezzavilla, M. and Pepper, M.S. Establishment and equilibrium levels of deleterious mutations in large populations.
2. Du Plessis N.M, Haeri Mazanderani A, Sherman G, Muller C.J.B, Avenant T, Pepper M.S, Goga A.E. Seroreversion in a birth PCR tested, HIV exposed PCR negative PMTCT option B/B+ cohort at 9 months - 46 - of age using rapid HIV tests kits and HIV ELISA: follow-up of infants from the Very Early Infant Diagnosis of HIV (VEID) study, Gauteng, South Africa.
3. Du Plessis N.M, Muller C.J.B, Avenant T, Pepper M.S, Goga A.E. Later growth outcomes of birth PCR tested, HIV exposed PCR negative infants with universal maternal cART exposure: follow-up cohort from the Very Early Infant Diagnosis of HIV (VEID) study, Gauteng, South Africa.
4. Kallmeyer K., André-Lévigne D., Baquié M., Krause K.H., Pepper M.S., Pittet-Cuénod B. and Modarressi A. Fate of systemically and locally administered adipose-derived mesenchymal stromal cells and their effect on wound healing.
5. Ambele M.A., van Zyl A., Pepper M.S., van Heerden M.B. and van Heerden W.F.P. Genetic heterogeneity: A unique assessment of clinically identical cases of oral cancer.
6. Ballot D., Rakotsoane D., Cooper P.A., Ramdin T., Chirwa T. and Pepper M.S. A prospective observational study of developmental outcomes in survivors of neonatal hypoxic ischaemic encephalopathy in South Africa.
7. Tshabalala M., Vather K., Nelson D., Anley D., Christoffels A. and Pepper M.S. Mixed resolution HLA~A, ~B, ~C, ~DRB1, ~DQA1, ~DQB1 and ~DPB1 diversity in South African populations.
8. Dessels C., Ambele M.A. and Pepper M.S. The effect of medium supplementation and serial passaging on the transcriptome of adipose-derived stromal cells expanded in vitro.
9. Wolmarans E., Durandt C., Dessels C., Ambele M. and Pepper M.S. Analysis of the side population in human adipose-derived stromal cells.
Review Articles and Editorials
Total impact factor: 361.658 Number of publications: 93 (13 without IF) Mean impact factor per article: 4.52 (As of March 2019)
No. Authors Title Journal Impact Factor 1 Pepper M.S. Dance - a suitable form of S. Afr. Med. J. 2.163 exercise? A physiological 66: 883-888 (1984). appraisal. 2 Montesano R., Pepper M. Angiogenesis in vitro: News Physiol. Sci. 5.947 and Orci L. morphogenetic and invasive 5: 75-79 (1990). properties of endothelial cells. 3 Pepper M.S. and Montesano Proteolytic balance and capillary Cell Diff. Dev. R. morphogenesis. 32: 319-328 (1990).
4 Vassalli J.-D. and Pepper Tumor biology: membrane Nature 41.577 M.S. proteases in focus. 370: 14-15 (1994). 5 Fotsis T., Pepper M., Genistein, a dietary ingested J. Nutr. 4.398 Aldercreutz H., Hase T., isoflavonoid, inhibits cell 125: 790S-797S (1995). Montesano R. and proliferation and in vitro Schweigerer L. angiogenesis. 6 Pepper M.S., Mandriota S.J., Angiogenesis regulating cytokines: Curr. Top. Microbiol. 4.427 Vassalli J.-D., Orci L. and activities and interactions. Immunol. Montesano R. 213 (Pt 2): 31-67 (1996). - 47 -
7 Pepper M.S., Montesano R., Angiogenesis: a paradigm for Enzyme Protein Mandriota S.J., Orci L. and balanced extracellular proteolysis 49: 138-162 (1996). Vassalli J.-D. during cell migration and morphogenesis. 8 Pepper M.S. Positive and negative regulation of Vasc. Med. 2.393 angiogenesis: from cell biology to 1: 259-266 (1996). the clinic. 9 Pepper M.S. Transforming growth factor-beta: Cytokine Growth F. 6.395 vasculogenesis, angiogenesis and R. vessel wall integrity. 8: 21-43(1997). 10 Pepper M.S. Manipulating angiogenesis: from Arterioscl. Thromb. 6.086 basic science to the bedside. Vasc. Biol. 17: 605-619 (1997). 11 Montesano R., Soriano J.V., Induction of epithelial branching J. Cell. Physiol. 3.923 Pepper M.S. and Orci L. tubulogenesis in vitro. 173: 152-161 (1997). 12 Soriano J.V., Pepper M.S., Roles of hepatocyte growth J. Mammary Gland 2.963 Orci L. and Montesano R. factor/scatter factor and Biol. Neoplasia transforming growth factor-1 in 3: 133-150 (1998). mammary gland ductal morphogenesis. 13 Fotsis T., Pepper M.S., Phytoestrogens and inhibition of Baillieres Clin. Montesano R., Aktas E., angiogenesis. Endocrinol. Metab. Breit S., Schweigerer L., 12: 649-666 (1998). Rasku S., Wahala K. and Adlercreutz H. 14 Mandriota S.J. and Pepper Lymphangiogenèse et activité J. Soc. Biol. M.S. biologique du facteur de croissance 193: 159-163 (1999). vasculaire endothéliale-C. 15 Pepper M.S. Angiogenèse et morphogenèse de Médecine Sciences 12: l’arbre vasculaire: de la biologie 1378-1386 (2000). cellulaire à la clinique. 16 Pepper M.S. Lymphangiogenesis and tumor Lymphology 0.976 metastasis: more questions than 33: 144-147 (2000). answers. 17 Pepper M.S. Lymphangiogenesis and tumor Clin. Cancer Res. 10.199 metastasis: myth or reality? 7: 462-468 (2001). 18 Van Trappen P.O. and Lymphangiogenesis and lymphatic Gynecol. Oncol. 4.540 Pepper M.S. microdissemination. 82: 1-3 (2001). 19 Pepper M.S. Extracellular proteolysis and Thromb. Haemostasis 4.952 angiogenesis. 86: 346-355 (2001). 20 Pepper M.S. Role of the matrix Arterioscl. Thromb. 6.086 metalloproteinase and plasminogen Vasc. Biol. activator-plasmin systems in 21: 1104-1117 (2001). angiogenesis. 21 Van Trappen P.O. and Lymphatic dissemination of tumor Lancet Oncol. 26.303 Pepper M.S. cells and the formation of 3: 44-52 (2002). micrometastases. 22 Orci L. and Pepper M.S. Microscopy: an art? Nat. Rev. Mol. Cell 35.612 Biol. 3: 133-137 (2002). 23 Nisato R.E., Tille J.-C. and Lymphangiogenesis and tumor Thromb. Haemostasis 4.952 Pepper M.S. metastasis. 90: 591-597 (2003). 24 Pepper M.S. and Skobe M. Lymphatic endothelium: J. Cell Biol. 8.784 morphological, molecular and 163: 209-213 (2003). functional properties. 25 Pepper M.S., Tille J.-C., Lymphangiogenesis and tumor Cell Tissue Res. 3.043 - 48 -
Nisato R. and Skobe M. metastasis. 314: 167-177 (2003). 26 Tille J.-C. and Pepper M.S. Hereditary vascular anomalies: new Arterioscl. Thromb. 6.086 insights into their pathogenesis. Vasc. Biol. 24: 1578-1590 (2004). 27 Pathak A.P., Bhujwalla Z.M. Visualizing function in the tumor- Lymphatic Res. Biol. 1.903 and Pepper M.S. associated lymphatic system. 2: 165-172 (2004). 28 Pepper M.S. Polymorphisms in the endothelial J. Neurosurg. 4.318 nitric oxide synthase gene and the 102: 433 (2005). tendency for aneurysm rupture. 29 Van Trappen P.O. and Lymphangiogenesis in human Angiogenesis 4.351 Pepper M.S. gynaecological cancers. 8: 137-145 (2005). 30 van der Merwe M.T. and Obesity in South Africa. Obesity Rev. 8.483 Pepper M.S. 7: 315-322 (2006). 31 Van der Auwera I., Cao Y., First international consensus on the Brit. J. Cancer 5.922 Tille J.C., Pepper M.S., methodology of lymphangiogenesis 95: 1621-1625 (2006). Detmar M., Jackson D.G., quantification in solid human Fox S.B., Harris A.L., Dirix tumours. L.Y., Vermeulen P.B. 32 Pepper M.S. and van der The genetics of obesity. S. Afr. Cardiol. Merwe M.T. Stroke J. Spring: 48,50 (2007). 33 Pathak A.P., Hochfeld W.E., Circulating and imaging markers Angiogenesis 4.351 Goodman S.L. and Pepper for angiogenesis. 11: 321-325 (2008). M.S. 34 Pepper M.S. The stem cell regulatory S. Afr. Med. J. 2.163 environment in South Africa: cause 99: 505-507 (2009). for concern. 35 Logan M.G. and Pepper The genetics of obesity: the role of J. Endocrinol. Metab. 0.320 M.S. the melanocortin 4 receptor. Diabetes S. Afr. 15: 45-47 (2010). 36 Pepper M.S. Cell-based therapies: navigating S. Afr. Med. J. 2.163 troubled waters. 100: 34-35 (2010). 37 Pepper M.S. The human genome and molecular S. Afr. Med. J. 2.163 medicine: promises and pitfalls. 100:722-724 (2010). 38 Pepper M.S. Regaining perspective on stem S. Afr. Family cells. Practice 52: 164 (2010). 39 Pepper M.S. The healing power of stem cells: S. Afr. Family why we need rules. Practice 52: 365 (2010). 40 Mabeta P. and Pepper M.S. Hemangiomas: current therapeutic Int. J. Dev. Biol. 1.579 strategies. 55: 431-437 (2011). 41 Slabbert M.N. and Pepper No-fault liability of health care S. Afr. Med. J. 2.163 M.S. providers in therms of the 101: 800-801 (2011). Consumer Protection Act. 42 Pepper M.S. Launch of the Southern African S. Afr. Med. J. 2.163 Human Genome Programme. 101: 287-288 (2011) 43 Warnich L., Drögemöller Pharmacogenomic research in Curr. B.I., Pepper M.S., Dandara C South Africa: lessons learned and Pharmacogenomics and Wright G.E.B. future opportunities in the rainbow Personalized Med. nation. 9: 191-207 (2011). 44 Myburgh R., Hochfeld W.E., Cardiovascular pharmacogenetics. Pharmacol. 10.376 Dodgen T.M., Ker J. and Therapeut. Pepper M.S. 133: 280-290 (2012). 45 Meissner-Roloff M. and Stem cell research engenders S. Afr. J. Sci. 1.191 Pepper M.S. interdisciplinary collaboration in 108: 5-6 (2012). - 49 -
science, ethics and religion. 46 Pepper M.S. Partial relief from the regulatory S. Afr. Med. J. 2.163 vacuum involving human tissues 102: 736-737 (2012). through enactment of Chapter 8 of the National Health Act and regulations thereto. 47 Pepper M.S. Enactment of Chapter 8 of the S. Afr. J. Bioethics 0.380 National Health Act and Law. regulations thereto. 5: 60 (2012). 48 Potgieter M., Pretorius E. Primary and secondary coenzyme J. Nutrition 4.398 and Pepper M.S. Q10 deficiency: the role of 71: 180-188 (2013). therapeutic supplementation. 49 Jackson C. and Pepper M.S. Opportunities and barriers to Stem Cell Res. Ther. 4.963 establishing a cell therapy 4 : 54 (2013). programme in South Africa. 50 Barash C.I. and Pepper M.S. Editorial: Special issue Appl. Translational pharmacogenomics & personalized Genomics. medicine. 2: 1-2 (2013). 51 Barmania F. and Pepper C-C chemokine receptor-5 (CCR5): Appl. Translational M.S. an emerging target for the control Genomics. of HIV infection. 2: 3-16 (2013). 52 Meissner-Roloff M. and Curbing stem cell tourism in South Appl. Translational Pepper M.S. Africa. Genomics. 2: 22-27 (2013). 53 Alessandrini M., Asfaha CYP450 pharmacogenetics in Drug Metab. Rev. 4.450 S.M., Dodgen T.M., African populations. 45: 253-75 (2013). Warnich L. and Pepper M.S. 54 Ali A.T., Hochfeld W.E. Adipocyte and adipogenesis. Eur. J. Cell Biol. 2.939 Myburgh R. and Pepper 92:229-236 (2013). M.S. 55 Alessandrini M. and Pepper Priority pharmacogenetics for the Pharmacogenomics 2.302 M.S. African continent: focus on 15:385-400 (2014) cytochrome P450. 56 Čolić A., Alessandrini M. Pharmacogenetics of CYP2B6, Drug Metabolism 4.450 and Pepper M.S. CYP2A6, and UGT2B7 in HIV Rev. treatment in African populations: 13: 1-13 (2014) focus on efavirenz and nevirapine. 57 Kallmeyer K. and Pepper Homing properties of mesenchymal Expert Opinion on 3.974 M.S. stromal cells. Biological Therapy. 15: 477-479 (2015) 58 Atashi F., Modarressi- The role of reactive oxygen species Stem Cells and 3.315 Ghavami A. and Pepper in mesenchymal stem cell Development. M.S. adipogenic and osteogenic 24: 1150-1163 (2015) differentiation : a review. 59 van der Westhuizen F.H., Understanding the implications of Human mutation. 5.359 Sinxadi P., Dandara C., mitochondrial DNA variation in the 36: 569-571 (2015) Smuts I., Riordan G., health of black southern African Meldau S., Malik A., populations: the 2014 Workshop. Sweeney M., Tsai Y., Towers W., Louw R., Gorman G., Payne B., Soodyall H., Pepper M.S. and Elson J. 60 Pepper M.S Gender and sexual diversity. S. Afr. Med. J. 2.163 Changing paradigms in an ever- 105: 746-747 (2015). changing world. - 50 -
61 Pepper M.S. SAJBL – Flagship special stem cell S. Afr. J. Bioethics 0.380 issue. Law. 8: 2-3 (2015). 62 Pepper M.S., Slabbert M.N. Human tissue legislation in South S. Afr. J. Bioethics 0.380 Africa: focus on stem cell research Law. and therapy. 8: 4-11 (2015). 63 Slabbert M.N. and Pepper A global comparative overview of S. Afr. J. Bioethics 0.380 M.S. the legal regulation of stem cell Law. research and therapy: lessons for 8: 12-22 (2015). South Africa? 64 Slabbert M.N., Pepper M.S. Stem cell tourism in South Africa: S. Afr. J. Bioethics 0.380 and Mahomed S. a legal perspective. Law. 8: 41-45 (2015). 65 Reznichenko A.S., Huyser C. Mitochondrial transfer: ethical, S. Afr. J. Bioethics 0.380 and Pepper M.S. legal and social implications in Law. assisted reproduction. 8:32-35 (2015). 66 Pepper M.S., Gouveia C. and Legislation governing pluripotent S. Afr. J. Bioethics 0.380 Slabbert M.N. stem cells in South Africa. Law. 8: 32-35 (2015). 67 Chira S., Jackson C.S., Progress towards safe and efficient Oncotarget. 0 Oprea I., Ozturk F., Pepper gene therapy vectors. 6: 30675-30703 (2015). M.S., Diaconu I., Braicu C., Calin G., Berindan-Neagoe I. 68 Tshabalala M., Mellet J. and Human Leukocyte Antigen J. Immunol. Res. 3.298 Pepper M.S. Diversity: a southern African Article ID 746151, 11 perspective. pages (2015)
69 Stewart C. Pepper M.S. Cystic fibrosis on the African Genet. Med. 9.973 continent. 18: 653-662 (2016) 70 Meldau S., Riordan G., van Could we offer mitochondrial S. Afr. Med. J. 2.163 der donation or similar assisted 106: 234-236 (2016). Westhuizen F., Elson J.L, reproductive technology to South Smuts I., Pepper M.S and African patients with mitochondrial Soodyall H. DNA disease? 71 Lombard Z., Aldous C., Implications of direct-to-consumer S. Afr. Med. J. 2.163 Baine F., Fieggen K., whole-exome sequencing in South 106: 139-140 (2016). Henderson B., Hoal E., Africa. Kinnear C., Kinsley N., Krause A., Lochan A., Macaulay S., September A., Spencer C., Urban M., Soodyall H., Pepper M., Ramsay M. and de Vries J. 72 Chaudhry M., Alessandrini Pharmacogenomics for infectious Appl. Translational M. and Pepper M.S. diseases in sub-Saharan Africa: Genomics. successes and opportunities. 9: 3-5 (2016). 73 Nicholson S.A and Pepper CRISPR-Cas: revolutionising S. Afr. Med. J. 2.163 M.S. genome engineering. 106: 870-871 (2016). 74 Alessandrini M., Chaudhry Pharmacogenomics and precision OMICS JIB Journal. 3.220 M., Dodgen T.M. and medicine in the context of adverse 20: 593-603 (2016). Pepper M.S. drug reactions: top 10 opportunities and challenges for the next decade. 75 Dessels C., Potgieter M. and Making the switch: alternatives to Frontiers Cell Dev. 3.650 Pepper M.S. foetal bovine serum for adipose- Biol. (section Stem Cell derived stromal cell expansion. Research). 4: 1-10 (Article 115) - 51 -
(2016). 76 Reznichenko A., Huyser C. Mitochondrial transfer: Appl. Translational 0.780 and Pepper M.S. implications for assisted Genomics. reproductive technologies. 11: 40-47 (2016). 77 Stewart C. and Pepper M.S. Cystic fibrosis in the African Ann. Am. Thorac. 4.006 diaspora. Soc. 14: 1-7 (2017). 78 Pepper M.S. Exporting DNA - striking a balance S. Afr. Med. J. 2.163 between preventing exploitation 107: 106-107 (2017). and promoting innovation. 79 Alessandrini M., Kappala S. AMLprofiler: a diagnostic and Methods Mol. Biol. and Pepper M.S. prognostic microarray for acute 1633: 101-123 (2017). myeloid leukemia. 80 Arbuthnot P., Maepa M.B., The state of gene therapy research Gene Therapy 3.203 Ely A. and Pepper MS. in Africa, its significance and 24:581-589 (2017). implications for the future. 81 Senthebane D.A., Rowe A., The role of tumor Int. J. Mol. Sci. 3.687 Thomford N.E., Shipanga microenvironment in 18: E1586 (2017). H., Munro D., Al Mazeedi chemoresistance: To survive, keep M.A.M., Almazyadi H.A.M., your enemies closer. Kallmeyer K., Dandara C., Pepper M.S., Parker M.I. and Dzobo K. 82 Lévigne, D., Modarressi A., Reactive oxygen species and NOX Int. J. Mol. Sci. 3.687 Pepper, M.S. and Pittet- enzymes are emerging as key 18 (10) (2017). Cuénod, B. players in cutaneous wound repair. 83 Meisner-Roloff M., Gaggia Strategies for screening cord blood Global Health, L., Vermeulen M., Haeri for a public cord blood bank in high Epidemiol. Genomics. Mazanderani A., du Plessis HIV prevalence regions. 3: e9 (2018). N.M., Steel H. and Pepper M.S. 84 Helena J.M., Joubert A.M., Deoxyribonucleic acid damage and Int. J. Mol. Sci. 3.687 Grobbelaar S., Nolte E.M., repair: capitalizing on our 19 (4) (2018). Nel M., Pepper M.S., understanding of the mechanisms Coetzee M. and Mercier of maintaining genomic integrity A.E. for therapeutic purposes. 85 Dessels C., Alessandrini M., Factors influencing the umbilical Stem Cells 4.929 Pepper M.S. cord blood stem cell industry: an Translational Med. evolving treatment landscape. 7: 643-650 (2018). 86 van Rensburg J., Cystic fibrosis in South Africa: a S. Afr. Med. J. 2.163 Alessandrini M., Stewart C. changing diagnostic paradigm. 108 (8): 624-628 and Pepper M.S. (2018). 87 Pepper M.S., Pope A., Kling Ethical considerations in the S. Afr. Med. J. 2.163 S., Alessandrini M., van application of cell and gene 108 (12): 1027-1029 Staden W. Green R.J. therapies in children. (2018). 88 Pepper M.S., Dandara C., de Consensus Study on the Ethical, S. Afr. J Science 1.191 Vries J., Dhai A, Legal and Social Implications of 114 (11/12): 1-3 Labuschaigne M., Genetics and Genomics in South (2018). Mnyongani F., Moodley K., Africa. Olckers A., Pope A., Ramesar R., Ramsay M., Soodyall H. and Towers, W. 89 Wolmarans E., Nel S., Side population: its use in the study Stem Cells Int. 3.989 Durandt C., Mellet J. and of cellular heterogeneity and as a Article ID 2472137 (7 Pepper M.S. potential enrichment tool for rare pages) (2018). - 52 -
cell populations 90 Pepper M.S., Alessandrini Cell and gene therapies at the S. Afr. Med. J. 2.163 M., Pope A., van Staden W. forefront of innovative medical In press (2019). and Green R.J. care: implications for South Africa. 91 Ely A., Bloom K., Maepa Gene and cell therapy in South S. Afr. Med. J. 2.163 B.M., Mahlangu J.N., Pepper Africa: current status and future In press (2019). M.S. and Arbuthnot P. prospects. 92 Alessandrini M., Krause Transplantation of gene modified S. Afr. Med. J. 2.163 K.H., Speck R. and Pepper hematopoietic stem cells: In press (2019). M.S. Application and clinical considerations. 93 Wolmarans E., Mellet J., Heterogeneity of cell therapy S. Afr. Med. J. 2.163 Ambele M., Durandt C. and products In press (2019). Pepper M.S. 94 Grobbelaar S., Mercier A.E., Hematopoietic stem cell S. Afr. Med. J. 2.163 Durandt C., Brittain D. and transplantation. In press (2019). Pepper M.S. 95 Erjaee A., Bagherpour M., Primary Immunodeficiency in S. Afr. Med. J. 2.163 van Rooyen C., van den Berg Africa – a review. In press (2019). S., Kinnear C.J., Green R.J. and Pepper M.S. 96 Mellet J., Tshabalala M., Human leukocyte antigen (HLA) S. Afr. Med. J. 2.163 Agbedare O., Meyer P., Gray diversity and its clinical In press (2019). C.M. and Pepper M.S. applications in South Africa. 97 Durandt C., Potgieter J.C., HIV and hematopoiesis. S. Afr. Med. J. 2.163 Nel J.G., Herd C., Mellet J. In press (2019). and Pepper M.S. 98 Staunton C., Adams R., Safeguarding the future of genomic S. Afr. Med. J. 2.163 Botes M., Dove E.S., Horn research in South Africa: broad In press (2019). L., Labuschaigne M., Loots consent and the Protection of G., Mahomed S., Makuba J., Personal Information Act 2013 Olckers A., Pepper M.S., Pope A., Ramsay M., Loideain N.N. and de Vries J. 100 Pepper M.S., Dandara C., de Response to Thaldar et al. S. Afr. J Science 1.191 Vries J., Dhai A, 114 (11/12): 1-3 Labuschaigne M., (2018). Mnyongani F., Moodley K., Olckers A., Pope A., Ramesar R., Ramsay M. and Towers, W.
Manuscripts Submitted for Publication
1. Alessandrini M., Preynat-Seauve O. and Pepper M.S. Stem cell therapy for neurological disorders.
2. Ali A.T., Al-ani O., Naidoo N. and Pepper M.S. Childhood obesity.
3. Ruiz de Castañeda R., Sheath D.J, Bempong N.E, Raviglione M., Machalaba C., Pepper M.S, Vayena E., Ray N., Wernli D., Escher G., Grey F., Elger B.S, Helbing D., Kleineberg K.K, Beran D., Miranda J.J., Huffman M.D., Hersch F., Andayi F., Thumbi S.M., D’Acremont V., Hartley M.A., Gilbert S.S., Zinsstag J., Larus J., Rodríguez-Martínez M., Guerin P.J., Merson L., Ngyuen V.K., Rühli F., Geissbuhler A., Salathé M., Bolon I., Boehme C., Berkley S., Valleron A.J., Keiser O., Kaiser L., Eckerle I., Utzinger J. and Flahault A. Precision Global Health: a roadmap for augmented action. - 53 -
Chapters in Books
No. Authors Chapter Title Book Ref 1 Montesano R., The control of In: Pathophysiology of pulmonary cells. Endothelial Pepper M.S., angiogenesis: endothelial and mucus producing cells. A. Junod, D. Olivieri Vassalli J.-D. and cell-matrix interactions and and E. Pozzi, Eds. Masson Italia Periodici (Milan). Orci L. extracellular proteolysis. 1-17 (1991). 2 Montesano R., Modulation of angiogenesis In: Angiogenesis: key principles, science, Pepper M.S., in vitro. technology, medicine. P.B. Weisz, R. Langer and R. Vassalli J.-D. and Steiner, Eds. Birkhäuser Verlag (Basel). Orci L. 129-136 (1992). 3 Pepper M.S., Proteolytic balance and In: Angiogenesis: key principles, science, Vassalli J.-D., Orci capillary morphogenesis in technology, medicine. P.B. Weisz, R. Langer and R. L. and Montesano vitro. Steiner, Eds. Birkhäuser Verlag (Basel). R. 137-145 (1992). 4 Montesano R., The role of growth factors In: Frontiers in endocrinology. Volume 6: Vassalli J.-D., Orci and extracellular matrix in Developmental endocrinology. P.C. Sizonenko, L. and Pepper M.S. angiogenesis and epithelial M.L. Aubert and J.-D. Vassalli, Eds. Ares-Serono morphogenesis. Symposia Publications (Rome). 43-66 (1994). 5 Pepper M.S., Angiogenesis in vitro: In: Angiogenesis: molecular biology, clinical Vassalli J.-D., Orci cytokine interactions and aspects. M.E. Maragoudakis, P.M. Gullino and P.I. L. and Montesano balanced extracellular Lelkes, eds. Plenum Press (New York):. R. proteolysis. 149-170 (1994). 6 Fotsis T., Pepper Inhibitors of angiogenesis In: Molecular, cellular and clinical aspects of M.S., Aktas E., in human urine. angiogenesis. M.E. Maragoudakis, Ed. Plenum Joussen A., Kruse Press (New York). F., Adlercreutz H., 213-227 (1996). Wähälä K., Hase T., Montesano R. and Schweigerer L. 7 Pepper M.S., Endothelial cells In: Tumour angiogenesis. R. Bicknell, C.E. Lewis Tacchini-Cottier transformed by and N. Ferrara, Eds. Oxford University Press F., Sabapathy K., polyomavirus middle T (Oxford). Montesano R. and oncogene: a model for 309-331 (1997). Wagner E.F. hemangiomas and other vascular tumours. 8 Montesano R. and Three-dimensional in vitro In: Vascular morphogenesis: in vivo, in vitro, in Pepper M.S. assay of endothelial cell mente. C.D. Little, V. Mironov and H. Sage, Eds. invasion and capillary tube Birkhäuser Boston (Cambridge, MA). morphogenesis. 79-110 (1998). 9 Pepper M.S. and Eléments d’angiogenèse In: Dermatologie et maladies sexuellement Saurat J.-H. cutanée. transmissibles, 3ème édition. J.-H. Saurat, E. Grosshans, P. Laugier, J.-M. Lachapelle, Eds. Masson (Paris). 626-627 (1999). 10 Pepper M.S. Angiogenesis and vascular In: Hemostasis and Thrombosis: Basic Principles morphogenesis. and Clinical Practice. R.W. Colman, J. Hirsh, V.J. Marder, A.W. Clowes and J.N. George, Eds. Lippincott-Raven Publishers (Philadelphia). 771-779 (2001). 11 Montesano R. and Capillary morphogenesis in In: Tumor angiogenesis and microcirculation. E.E. Pepper M.S.: vitro: cytokine interactions Voest and P.A. D'Amore, Eds. Marcel Dekker Inc. and balanced proteolysis. (New York). - 54 -
111-141 (2001). 12 Iruela-Arispe M.L., Vascular morphogenesis In: Vascular Morphogenesis in the Female Ortega M.A., the mammary gland – Reproductive System. Cardiovascular Molecular Oikemus S. and introduction and overview. Morphogenesis Series. H.G. Augustin, M.-L. Iruela- Pepper M.S. Arispe, P.A.W. Rogers and S.K. Smith, Eds. Birkhäuser (Boston). 3-24 (2001). 13 Saaristo A., Growth factor regulation of In: Vascular Morphogenesis in the Female Karkkainen M.J., physiological angiogenesis Reproductive System. Cardiovascular Molecular Alitalo K., in the mammary gland. Morphogenesis Series. H.G. Augustin, M.-L. Iruela- Montesano R., Arispe, P.A.W. Rogers and S.K. Smith, Eds. Iruela-Arispe M.-L. Birkhäuser (Boston). and Pepper M.S. 25-40 (2001). 14 Pepper M.S., Angiogenesis-regulating In: The New Angiotherapy. T.-P. Fan and E.C. Mandriota S.J. and cytokines. Kohn, Eds. Humana Press Inc. (Totowa, NJ). Montesano R. 7-40 (2002). 15 Pepper M.S. Role of the plasminogen In: Plasminogen: structure, activation and activator-plasmin system in regulation. D.M. Waisman, Ed. Kluwer angiogenesis. Academic/Plenum Publishers (New York). 269-290 (2003). 16 Tille J.-C., Nisato Lymphangiogenesis and In: Novartis Foundation Symposium 256: Cancer R. and Pepper M.S. tumour metastasis. and Inflammation. John Wiley and Sons Ltd (Chichister, UK). 112-136 (2004). 17 Pepper M.S. and Eléments d’angiogenèse In: Dermatologie et infections sexuellement Saurat J.-H. cutanée. transmissibles, 4ème édition. J.-H. Saurat, E. Grosshans, P. Laugier, J.-M. Lachapelle, Eds. Masson (Paris). 694-695 (2004). 18 van der Merwe Energy conservation during In: Voyages in Science. Essays by South African M.T. and Pepper evolution: the impact on anatomists in honour of Philip V. Tobias’ 80th M.S. obesity, a modern birthday. G. Strkalj, N. Pather and B. Kramer, Eds. epidemic. Content Solutions (Pretoria). 141-157 (2005). 19 Pepper M.S. The lymphatic system. In: Encyclopedia of the Microvasculature. D. Shepro, Ed. Elsevier Inc. (San Diego). 523-527 (2005). 20 Harrison J.A., Angiogenesis, In: Hemostasis and Thrombosis: Basic Principles Buser R. and lymphangiogenesis and and Clinical Practice. 5th edition. R.W. Colman, V.J. Pepper M.S. vascular morphogenesis. Marder, A.W. Clowes, J.N. George and S.Z. Goldhaber Eds. Lippincott Williams and Williams (Philadelphia). 679-689 (2005). 21 Pepper M.S. and The lymphatic vascular In: Selected topics in cancer modeling: genesis, Lolas G. system in evolution, immune competition, and therapy. N. lymphangiogenesis, Bellomo, M. Chaplain, and E. De Angelis Eds. invasion and metastasis: a Series: Modelling and Simulation in Science, mathematical approach. Engineering and Technology. Birkhauser (Boston, MA). 255-276 (2008). 22 Durandt C., Asfaha Pharmacogenetics. In: Molecular Medicine for Clinicians. B. S.M. and Pepper Mendelow, M. Ramsay, N. Chetty and W. Stevens M.S. Eds. Wits University Press (Johannesburg). 433-437 (2009). 23 Nisato R.E., Buser Lymphatic endothelial In: Methods in Molecular Medicine 467: R. and Pepper M.S. cells: establishment of Angiogenesis Protocols 2nd edition. S. Martin and C. - 55 -
primaries and Murray Eds. Humana Press Inc. (New York, NY). characterization of 113-126 (2009). established lines. 24 Pepper M.S. and Eléments d’angiogenèse In: Dermatologie et infections sexuellement Saurat J.-H. cutanée. transmissibles, 5ème édition. J.-H. Saurat, J.-M. Lachapelle, D. Lipsker, L. Thomas, Eds. Masson (Paris) 698-699 (2009). 25 Hochfeld W.E, Pharmacogenetics and In: Genomics and Health in the Developing World. Asfaha S.M., pharmacogenomics in the D. Kumar Ed. Oxford University Press (New York): Alessandrini M., developing world. 168-191 (2011). Dodgen T.M., Myburgh M., Eloff A. and Pepper M.S. 26 Botes M.W., Stem cell therapy: accepted In: Stem Cells in Clinical Applications: Stem cell Slabbert M.N., therapies and managing the Processing. Series Ed.: P.V. Pham, Springer Alessandrini M. hope of society. International Publishing (Switzerland). and Pepper M.S. 1-35 (2016). 27 van Vollenstee Isolation and In: Stem Cells in Clinical Applications: Stem cell F.A., Kallmeyer characterization of adipose Processing. Series Ed.: P.V. Pham, Springer K., Dessels C., de derived stromal cells. International Publishing (Switzerland). Villiers D., 131-161 (2016). Potgieter M., Durandt C. and Pepper M.S. 28 van Vollenstee Harvesting and collection In: Stem Cells in Clinical Applications: Stem cell F.A., Hoffmann D. of adipose tissue for the Processing. Series Ed.: P.V. Pham, Springer and Pepper M.S. isolation of adipose derived International Publishing (Switzerland). stromal/stem cells. 199-220 (2016). 29 Steel H.C., Cord blood stem cell In: Stem Cells in Clinical Applications: Stem cell Alessandrini M., banking. Processing. Series Ed.: P.V. Pham, Springer Mellet J., Dessels International Publishing (Switzerland). C., Oloyo A. and 163-180 (2016). Pepper M.S. 30 Pepper M.S. and Eléments d’angiogenèse In: Dermatologie et infections sexuellement Saurat J.-H. cutanée. transmissibles, 6ème édition. J.-H. Saurat, et al., Eds. Elsevier Masson (Paris). 754-755 (2017). 31 Mabeta P. and Manipulating the tumor In: Frontiers in Anti-Cancer Drug Discovery. Atta- Pepper M.S. microenvironment: ur-Rahman & M. Iqbal Choudhary (Eds.) Bentham opportunities for Science Publishers. therapeutic targeting. Vol. 8: 3-32 (2017). 32 Jackson C.S., Clinical safety and In: Stem Cells in Clinical Applications. Safety, Alessandrini M. applications of stem cell Ethics and Regulations. Phuc Van Pham and Achim and Pepper M.S. gene therapy. Rosemann (Eds.). Springer. 67-89 (2017). 33 de Villiers D., The role of reactive oxygen In: Advs Exp. Medicine, Biology, subseries Potgieter M., species in adipogenesis. Innovations in Cancer Research and Regenerative Durandt C., Adam Medicine Vol. 1: Stem Cell Biology and L., Ambele M. and Engineering. Pepper M.S. In press (2017). 34 Oloyo A.K., Contrasting views on the In: Advs Exp. Medicine, Biology, subseries Ambele M and role of mesenchymal Innovations in Cancer Research and Regenerative Pepper M.S. stromal/stem cells in Medicine Vol. 1: Stem Cell Biology and tumour progression: a Engineering. systematic review of In press (2017). - 56 -
experimental design. 35 Wolmarans E., Boy Cancer stem cells in head In: Advs Exp. Medicine, Biology, subseries S., Nel S. and and neck carcinomas: Innovations in Cancer Research and Regenerative Pepper M.S. identification and possible Medicine Vol. 1: Cancer Biology and Therapeutics. therapeutic implications. In press (2017).
Patents
Patent full title: Stimulation, modulation and/or inhibition of endothelial proteolytic activity and/or angiogenic activity Patent number: WO 1999008522 A1 Description of patent: Vascular endothelial growth factor-B (VEGF-B) and vascular endothelial growth factor- C (VEGF-C) are angiogenic polypeptides. It has been shown that VEGF-B and -C are angiogenic in vitro especially in combination with bFGF. VEGF-C also increases plasminogen activator (PA) activity in bovine endothelial cell lines and this is accompanied by a concomitant increase in PA inhibitor-1. Addition of alpha-2- antiplasmin to bovine endothelial cells co-treated with bFGF and VEGF-C partially inhibits collagen gel invasion. Patent Assignee: Ludwig Inst Cancer Res; Univ Helsinki Licensing; Univ Geneva Inventors: Pepper M.S., Alitalo K., Eriksson U. Web address: http://www.google.com/patents/WO1999008522A1?cl=en Own contribution: Responsible for the key findings, namely synergism between antiogenic cytokines, and stimulation of angiogenic and proteolytic activity by these cytokines in vitro
Patent full title: Methods and compositions for directing migration of neural progenitor cells Patent number: US 2008/0118480 A1 Description of patent: Method for modulating the migration of neural progenitor cells in a mammal by exposing the cells to a VEGFR-2 ligand and FGF-2. Methods of treating neurological disorders by exposing the mammal to a VEGFR-2 ligand in the presence of FGF-2 are also provided. A composition including a biocompatible matrix associated with FGF-2 is also provided. Patent assignee: Imclone Systems Incorporated New York NY, USA Inventors: Zhang H., Vutsikas L., Pepper M.S., Kiss J.Z. Web address: http://www.google.com/patents/US20080118480 Own contribution: Invloved in the conceptualization and execution of the experiments leading to the key findings
Patent full title: Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids Patent number: WO 1997045143 A1 Description of patent: This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on the role of their signaling pathway in endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagged protein, as well as a substantially purified nucleic acid molecule or segment thereof encoding Jagged protein, or a functionally equivalent derivative, or allelic or species variant thereof. Patent assignee: Thomas Maciag, Roberto Montesano, Nat American Red Cross; Michael S. Pepper, Univ Geneve Michael K K Wong, Ann B Zimrin Inventors: Maciag T., Montesano R., Pepper M.S., Wong M.K.K., Zimrin A.B. Web address: http://www.google.com/patents/WO1997045143A1?cl=en Own contribution: Invloved in the conceptualization and execution of the experiments leading to the key findings
Patent full title: Transgenic cell selection Patent number: WO2014132137 A2 (published 04 September 2014) Application number: PCT PATENT: PCT/IB2014/000994 (based on US Provisional Application 61/771,331) - 57 - Description of patent: The invention relates generally to the field of molecular biology and medicine. More particularly, it concerns methods for production and selection of transgenic cells and vectors for the production of such cells. Inventors: Krause K.H., Suter D., Salmon P., Myburgh R., Pepper M. Web address: https://www.google.co.za/patents/WO2014132137A2?cl=en&dq=transgenic+cell+selection&hl=en&sa=X&ve d=0CBoQ6AEwAGoVChMIzfy-jeixyAIVyFsUCh2uxAEA Own contribution: Co-initiator of the HIV gene therapy project.
Patent full title: Method and kit for identifying gene mutations Patent number: US 2018 / 0320231 A1 (published 08 November 2018) Application number: US Patent App. 15/773,800, 2018 Description of patent: This invention relates to a method of identifying mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, a kit for performing said method, and furthermore to isolated nucleotide sequences being complementary to one or more mutations of the CFTR gene. Inventors: Green RJ, Masekela R, Stewart C, Pepper Ms. Patent Assignee: University of Pretoria Web address: https://patentimages.storage.googleapis.com/01/31/74/c15c978264cc2a/US20180320231A1.pdf Own contribution: Initiator of the project.
Technical/policy reports
1. Pepper M.S., Ramburan V.P. and Lamprecht S. Report on the BioSA / COFISA Intervention aimed at facilitating South African and Finnish business-to-business collaboration in the Biotechnology and Life Science sectors. May 2008. (56 pages)
2. Alessandrini M., Barnett J., Klose K., Pepper M.S. and van der Bijl P. Understanding Technology Transfer at higher education institutes (HEIs): A South African study. World Bank Institute. June 2010. (120 pages)
3. SAHGP Core Group (Bardien S., Christoffels A., Mphahlele J., Pepper M.S., Ramesar R., Ramsay M., Rees J., Soodyall H., Venter P. and Warnich L), Napier H. and SAHGP writing groups. Southern African Human Genome Programme. Report to the Dept. of Science and Technology, July 2011. (87 pages)
4. Coovadia J., Gray G., Dugmore H., Breyer C., Higginbotham D., Kiguli J., Kramer B., McIntyre J., Nel J., van Niekerk J., Pepper M., Singh J. Diversity in human sexuality. Implications for policy in Africa. Academy of Science of South Africa, May 2015. (94 pages) http://www.assaf.co.za/wp-content/uploads/2015/06/8-June-Diversity-in-human-sexuality1.pdf
5. De Vries J. et al. Ethics and Governance Framework for Best Practice in Genomic Research and Biobanking in Africa. February 2017. (11 pages)
6. Pepper M.S., Dandara C., de Vries J., Dhai A, Labuschaigne M., Mnyongani F., Moodley K., Olckers A., Pope A., Ramesar R., Ramsay M., Soodyall H. and Towers, W. Human Genetics and Genomics in South Africa: Ethical, Legal and Social Implications. Consensus Study conducted on behalf of the Academy of Science of South Africa. December 2018. (117 pages)
Position statements
1. National Biotechnology Advisory Committee (NBAC). Position statement on Stem Cell Regulations in South Africa. 2008. (Authored by Pepper M.S.)
2. National Biotechnology Advisory Committee (NBAC). Position statement on Genomic Sovereignty in South Africa. 2011. (Authored by Pepper M.S. and Slabbert M.N.)
- 58 - 3. South African Society of Obstetrics and Gynaecology (SASOG). Position statement on umbilical cord blood banking. Soma-Pillay P. and Pepper M.S. 17 March 2014. http://www.sasog.co.za/images/Umbilical_cord_blood_banking_March2014.pdf
Other Publications
1. Pepper M.S.: An approach to the injured dancer. Arabesque 21: pages 11,13,41, 1983.
2. Pepper M.S.: Understanding the injured dancer. S. Afr. J. Sports Med. 24: 9-13, 1984.
3. Kern P., Calza A.-M., Pittet-Cuenod B., Pepper M.S., Benador D., Lecoultre C., Rüfenacht D. and Bounameaux H.: Hémangiomes et malformations vasculaires: casuistique d'une consultation multidisciplinaire. Médecine et Hygiène 55: 118-123, 1997.
4. Hansson G., Carmeliet P. and Pepper M.: Tribute to Werner Risau: December 18, 1953-December 13, 1998. Arterioscl. Thromb. Vasc. Biol. 19: 829, 1999.
5. Pepper M.S. Lymphangiogenesis and tumor metastasis. Swiss Cancer Bulletin 21: 122-124, 2001.
6. Pepper M.S. Literature Watch – Summary and perspectives. Lymphatic Res. Biol. 1: 245-246, 2003.
7. Molecular and Metabolic Medicine Update newsletter. http://www.ampath.co.za/news.htm
Year Vol No Author Title 2006 2 3 Pepper Stem cell therapy 2 4 van der Merwe and Pepper The genetics of obesity 2 4 Pepper and Naude Blood conservation in South Africa 2 5 Pepper and Durandt Pharmacogenetics 2007 3 2 Naude, Watermeyer and Pepper The transfusion trigger 3 2 Pepper Controversial issues in the stem cell arena 3 3 Pepper and Jordaan Cell-based therapy in South Africa 3 4 Pepper, Gould and Crookes Therapeutic plasma exchange 3 4 Pepper A model for the co-existence of public and private stem cell banks 2008 4 1 Pepper Pharmacogenetics – where are we today? 4 2 Pepper Omega fatty acids -3, -6 and -9. Unraveling the mystery 4 3 Marrs, Pepper Peripheral blood stem cells for bone marrow transplantation 4 4 Pepper Blood conservation 4 5 Pepper, Krause, Stoltz, Sorce Rendering the immune system resistant to HIV – a potential therapeutic strategy? 4 5 Pepper Induced pluripotent stem cells 4 6 Pepper, Pathak A need for novel surrogate markers of angiogenesis 2009 5 2 Pepper The stem cell regulatory environment in South Africa
8. Report: Bioethics Forum on Stem Cell Banking, held at the Innovation Hub, Pretoria, on 15 June 2007. Compiled by: Dominique Schaub, Stephen Marrs, Doretha Thompson, Michael Pepper, Donrich Jordaan. 23 July 2007.
9. CIPS e-briefs. July / August 2007. www.policystudies.up.ac.za Cell-based therapy and the biotech sector in South Africa by Dr David Keetch, Prof Michael Pepper and Prof Jocelyn Webster. - 59 -
A model for the co-existence of public and private stem cell banks by Prof Michael Pepper. Banning private umbilical cord blood banks - a human rights analysis by Adv Donrich Jordaan, Prof Michael Pepper, Adv Christopher Woodrow and Adv Naude de Wet.
10. Report: The Human Tissue Regulatory Environment, held at the Innovation Hub, Pretoria, on 27 May 2009. Compiled by: Michael Pepper. July 2009.
11. Article series in Rolling Inspiration: Pepper. M.S. Stem cell, hard sell (September/October 2009) Pepper. M.S. Regaining perspective on stem cells (January/February 2010) Pepper. M.S. The healing power of stem cells: why we need rules (March/April 2010) Pepper. M.S. We are what we eat (July/August 2010) Pepper. M.S. The importance of keeping accurate records (September/October 2010) Potgieter M. and Pepper M.S. Stem cell therapy: 8 things to consider at decision making crunch time (January/February 2011) Potgieter M. and Pepper M.S. Stem cell therapy for neuromuscular disorders (September/October 2011).
12. Article series in the Muscular Dystrophy Foundation Magazine: Pepper. M.S. Stem cell, hard sell (Vol 32, pages 18-19, August, 2010) Pepper. M.S. Regaining perspective on stem cells (Vol. 33, pages 20-21, December 2010) Pepper. M.S. The healing power of stem cells: why we need rules (Vol. 34, pages 28-29, April 2011) Potgieter M. and Pepper M.S. Stem cell therapy for neuromuscular disorders (Vol. 35, pages 26-27, August 2011).
13. Article series in The Conversation (Africa): Pepper M.S. and Kramer B. The science behind a more meaningful understanding of sexual orientation. 10 June 2015. Pepper M.S. A beginner’s guide to stem cells. 19 August 2015. Pepper M.S. and Novitzky N. What lies behind the hype and hope of stem cell research and therapy. 19 August 2015. Pepper M.S., Scholefield J, Slabbert M and Ballo, R. Why South Africa needs better laws for stem cell research and therapy. 20 August 2015. Pepper M.S. and Slabbert M. South Africa’s struggle to control sham stem cell treatments. 21 August 2015. Pepper M.S. Mother Nature’s answer to our DNA’s infidelity and the discovery of DNA repair. 09 October 2015. Pepper M.S. Attitudes to gender and sexual diversity: changing global trands. 10 June 2019
14. Pepper M.S. Challenges raised by gene editing. “Forum.” Issues in Science and Technology (National Academy of Sciences) 32, no. 4: 5-6 (Summer 2016).
15. Pepper M.S. Genome editing and the genomics revolution. Article in Community Ch@: p21-23. July 2016. https://issuu.com/featzpublishing4/docs/c_chat_july
16. Pepper M.S. Remembering Ontlametse Phalatse - progeria patient and inspiration. Article on University of Pretoria website: News. 15 May 2017. http://www.up.ac.za/en/news/post_2477442-remembering-ontlametse-phalatse-progeria-patient-and- inspiration
17. Pepper M.S. Genome technologies, precision medicine and innovative therapies. Quest 14(3): a1 (2018).
18. Pepper MS: Opinion: Stem cell treatment – excitement is understandable but let’s tread carefully. Health 24, 12 June 2019.
- 60 - https://www.health24.com/Columnists/opinion-stem-cell-treatment-excitement-is-understandable-but-lets- tread-carefully-20190612
Material on the internet
Lectures on YouTube
UP expert lecture on Stem Cells https://www.youtube.com/watch?v=AeXqow7fcMk
Science and Cocktails lecture on Gender and Sexual Diversity https://www.youtube.com/watch?v=BqBhuGQpOBY
SAASTA Critical Thinker’s Forum on the Human Genome https://www.youtube.com/watch?v=bH6yu_L8TZ4 https://www.youtube.com/watch?v=9nZAjzrBtUc&list=PLKqGUQP5NxG4Pdy9_JGt4ArEB3UQOMmny&ind ex=4
Web-based programme on stem cells http://www.in3sixty.com/education/20110110_PUB/internet/lowres/pub_intro.html http://www.in3sixty.com/education/20110110_PUB/internet/lowres/pub_stemcells_lab1.htm
Podcast, Cystic Fibrosis in Africa. Stewart C. and Pepper M.S.
Landing page: http://www.nature.com/gim/podcast/index.html Podcast: http://www.nature.com/multimedia/podcast/gim/gim_02012016.mp3
Media
Carte Blanche CRISPR HIV Cure (24 July 2016) http://carteblanche.dstv.com/player/1080544/
ITV Understanding the miracles of stem cells (07 November 2018) https://www.youtube.com/watch?v=V3UD19I0zog&t=1s
University of Pretoria
UP Faculty of Health Sciences https://www.youtube.com/watch?v=rubunCESGAk https://www.youtube.com/watch?v=Pdgig3AamQI
Institute for Cellular and Molecular Medicine http://www.up.ac.za/institute-for-cellular-and-molecular-medicine
Launch of the UP Institute for Cellular and Molecular Medicine http://www.up.ac.za/en/institute-for-cellular-and-molecular-medicine/video
Gene therapy for HIV/AIDS https://www.youtube.com/watch?v=0NLIFYp4HkY&list=UU8yH-uI81UUtEMDsowQyx1g
- 61 -
Interactions with the Media
Entity Date Title Comment Printed and e-media Rosebank Killarney 2019, 31 May Indaba debates injustice By: Nadine Sibanda Gazette Sunday Times 2019, 05 May Delays derail clinical By: Bobby Jordan research trials Science 2019, 20 February A new law was supposed to By: Linda Nordling protect South Africans’ privacy. It may block important research instead Lab Management 2019, 01 January ASSAf calls for improved Science guidelines for gene editing Nature 2018, 07 December South Africa’s science By: Sarah Wild academy urges update to nation’s genetics laws Daily Maverick 2018, 07 December Scientists call for tighter By: Tony Carnie regulation of SA human genetics research Brain Waves 2018, 06 December Launch of the consensus By: Lesgo Masethe report on human genetics and genomics in South Africa news24 2018, 04 December Sceince body pushes for By: Duncan Alfreds Engineering News better human genetics Mail and Guardian ethics guidelines in South Africa Nature 2018, 18 April African scientists call for By: Linda Nordling more control of their continent’s genomic data Volksblad 2018, 16 February SA sal gou eerste genoom By: Elsabé Brits self kan karteer Beeld 2018, 16 February Suid Afrika sal binnekort By: Elsabé Brits eerste genoom self kan karteer Times Select 2018, 15 February Don’t bank your baby’s By: Katharine Child stem cells, it’s a money- making scam SciDevNet 2017, 05 April NCDs account for 23 per By: Sam Otieno cent of Africa’s disease burden Mail and Guardian 2017, 24 February Gene editing: By: Sarah Wild panelapproval ushers in new era Mail and Guardian 2016, 09 June Ethical issues dog genetic By: Sarah Wild testing and biobanks Mail and Guardian 2016, 05 February Scientists caution against By: Sarah Wild dangers of genetic modification Volksblad 2015, 23 September Stamsel-operasies beoog By: Rochelle Human teen sigverlies Business Day 2015, 23 September Genetic tests put discovery By: Tamar Kahn in new turf Mail and Guardian 2015, 29 August Stem cell research outstrips By: Sarah Wild legislation - 62 -
Mail and Guardian 2015, 29 August Blurred lines, loopholes By: Sarah Wild could brew up a storm in a petri dish Mail and Guardian 2015, 12 June “Un-African” sex myths By: Sarah Wild exploded Sunday Times 2015, 31 May Scientists a step closer to By: Tanya Farber creating designer babies Public Understanding 2015, June issue 5 A research institute for of Biotechnology South Africa’s patients Vrouekeur 2015, 10 April Supermense? By: Anne Marais SABC News 2014, 12 September Media, science experts By: Lerato Matlala debate science reporting in SA IOL Lifestyle 2014, 17 February Being gay is no conscious By: Lali van Zuydam decision - expert Pretoria News 2014, 12 February Being gay is no conscious By: Lali van Zuydam decision, says expert Business Day 2014, 14 January Proposed R2bn fund aims By: Tamar Kahn to boost bio-economy Mail and Guardian 2013, 18 October Baby, make those genes By: Sarah Wild talk Mail and Guardian 2013, 11 October SA lights a torch in the By: Sarah Wild genomic revolution Business Day 2013, 06 June Researchers seek clarity on By: Tamar Kahn human tissue rights Sunday Times 2013, 19 May Mapping the unique genes By: Bobby Jordan of Southern Africa Mail and Guardian 2013, 17 May Now the beauty of stem By: Sarah Wild cells is only skin deep Beeld 2013, 07 March Stamselbehandeling “is die By: Antoinette risiko werd” Pienaar Izindaba, South 2013, January; ‘Pioneer’ Paarl neuro sets By: Chris Bateman African Medical 103(1): 8-9 alarm bells ringing Journal Beeld 2012, 28 December Etiek van Stamselle By: Antoinette Pienaar Beeld 2012, 28 November Stamselle: etiese komitee By: Elzabé Brits moes kyk Die Burger 2012, 28 November Etiese komitee ‘is nie By: Elzabé Brits betrek’ Die Burger 2012, 27 November Kenners besorgd oor By: Elzabé Brits behandeling Beeld 2012, 26 November Geen bewys dat dit werk By: Elzabé Brits The Times 2012, 26 October Unborn kids ‘hold key to By: Katharine Child life’ Sunday Times 2012, 22 July Doctors are ‘sick and tired’ By: Bobby Jordan City Press 2012, 8 July Doctors lose patience as By: Eugene Botha suits spike Rapport 2012, 8 July Hof toe met jou, dokter ! By: Eugene Botha Business Day 2012, 13 January Diverse SA must tap stem By: Sarah Wild cells locally Die Burger 2011, 19 September Stamselle van naelstringe By: Elsabe Brits nou in SA bewaar Business Day 2011, 19 September Venture lifts hope for stem By: Sarah Wild cell progress The Centurion 2011, September The next major wave of - 63 -
commercial activity – Bio- entrepreneurship Business LIVE 2011, 15 September Stem cell storage divides By: Nashira Davids Medical Chronicle 2011, June SA human genome project will benefit local society Biotechnology – Bio-entrepreneurs, a new Executive Education breed in business Business Day 2010, 7 December Research into genetic By: Tamar Kahn variation should help disease prevention Medical Chronicle 2010, October Doing good work against great odds: the challenges faced in stem cell transplants Medical Chronicle 2010, August Bloodless medicine: techniques used to reduce the use of blood and its components The Mercury 2010, 1 June Clarity on stem cells By: Omeshnie Naidoo Business Day 2010, 18 February Tutu gives his genes to By: Tamar Kahn science The Mercury 2009, November Beware of bogus stem cell By: Omeshnie Naidoo therapies: expert warns Medical Chronicle 2009, November Public stem cell bank to move SA into the future of medical research Health 24 2009, 23 September Stem cell research: where it By: Carine Visagie is at Health 24 2009, 11 August Stem cells – hope or hype Financial Mail 2009, 7 August Past cell-by date By: Razina Munshi Weekend Argus 2009, 24 May Acute need for public stem By: Melanie Peters cell bank in SA FIT Pregnancy 2009, Mom’s the word – Where By: Lisa Morris February/March 33- to we come from? 34 Medical Chronicle 2008, July Bloodless programmes address global blood shortage Vrouekeur 2008, 28 March Boustene van ‘n nuwe lewe By: Tanya de Vente Pretoria News 2007, 20 September Scientist strive to stop By: Di Caelers pending clampdown on stem cell research Mail & Guardian – 2007, 14 September Netcare makes investment Online in stem cell development The Citizen 2007, 13 September Call for support of blood conservation projects Mail & Gaurdian – 2007, 13 September Call to support blood- Online conservation projects Netcare – Media 2007, 12 September Netcare calls on healthcare By: Martina Release professionals and SA Nicholson public to support blood conservation Rekord Oos/East 2007; 30 March Stem cells can now be By: Petro van (Local Paper) stored for later use Rensburg The Argus 2007, September New law will kill stem cell By: Di Caelers industry – experts - 64 -
Die Burger 2007, September Kenner maak sterk kapsie By: Elsabe Brits oor stamselwet Medical Chronicle 2006, October Blood conservation in South Africa Rapport 2006, 3 September ‘Ek sal alles probeer’ – By: Marenet Jordaan Stemsel-terapie bring hoop, al sê medici wát Netcare – Media 2006, 14 August Cutting edge institute By: Martina Release launched for cellular and Nicholson molecular medicine Rapport 2006, 13 Augustus Regering moet ongesonde By: Marenet Jordaan kos belas, sê medikus Medical Chronicle 2006, 8 August Umbilical cord blood stem cell therapy harmed by misinformation Mail & Guardian 2006, 4 August Soft sell on stem cells By: Belinda Beresford Insurance gateway – 2006, 20 July Netcare makes substantial Online investment in stem cell development Business iafrica – 2006, 19 July Netcare invests in stem Online cells Medical Chronicle 2006, July Stem cell storage: Insurance against future disease Financial Mail 2006, 5 May The ultimate wash cycle By: Claire Bisseker Netcells – Netcare 2006, May Umbilical cord blood stem By: Kim Long cell storage Netcare – Media 2006, 4 April Netcare’s blood By: Martina Release conservation institute to Nicholson address dire blood shortage in SA Rapport 2006, 5 February Etiekraad gee groen lig vir By: Elise-Marie harttegniek Tancred South African 2005, January Pharmacogenetics offers By: Chris Bateman Medical Journal hope Financial Mail 2004, 17 December Genes can reduce costs By: Peter Honey Financial Mail 2004, 1 July Race for a Cure By: Jacqui Pile The Scientist 17: 33- 2003 Cancer’s other conduit By: Scientist staff 34 (Steve Bunk) Méditorial 2000, 23 October Sur les pas de…. CAP Today 2000, May Cytokines’ steady march to By: Karin Titus labs Reuters Health 2000, 21 January High plasma level of By: Pam Harrison angiogenic cytokines may help in diagnosis of cancer L’illustré 41: 66-67 1999, 13 October Demain le pontage sera biologique Bio World 1997, 4 June Finnish researcher uncover By: Sharon Kingman International mechanisms that cause growth of endothelial cells – Lymph Le Temps 1998, 12 May Vaincre le cancer, c’est lui By: Anne Crisinel couper les vivres GHI 1994, 24 March Cancer: nouvelle piste á Genéve - 65 -
Le Nouveau 1994, 18 March Asphyzier et affamer les By: Anne Crisinel Quotidien tumeurs. Voie prometteuse de reserche sur le cancer Symptômes 1994, p22 Nouvelle substance New in Physical 1990, December; Vol New capillaries make their Science 5, 272-273 way by tightly regulated extracellular proteolysis SAMEDI Litteraire 1990, 10 November Bienfaits et méfaits de l’angiogenése Television ITV 2018, 07 November Understanding the miracles Interviewer: Julie of stem cells Alie Carte Blanche 2017, 26 February Three parents, one baby Produced by Eugene Botha Carte Blanche 2016, 24 July CRISPR HIV Cure Interviewer: Devi Sankaree Govender SABC 3 2014, 19 October Stem cells Interviewer: Lindile Mpanza SABC 3 2014, 04 August Stem cells Interviewer: Sipho Stuurman TVJ (TV Jamaica): 2013, 21 November Stem cells Smile Jamaica Kyknet: Nege maande 2013, 8 August Stem cells Dagbreek (eNews) 2013, 19 March Stem cells eTV (eNews) 2012, 13 July Medical Malpractice Litigation SABC 2009, 10 July Current Affairs Summit TV 2009, 13 February Stem cell problems Presenter: Jane van Renen SABC2 2008, 22 November Human interest issues, the Presenter: Nastassja Weekend Live arts, lifestyle and Tait entertainment Netcare TV: Matters 2008, 5 February Therapeutic Applications Medical of Stem Cells Netcare TV: Matters 2007, 6 November Blood conservation Medical Netcare TV: Matters 2007, 7 August Anaemia (Chairperson) Medical Netcare TV: Matters 2007, 4 July Hemochromatosis and (Chairperson) Medical Genetic Disorders Netcare TV: Matters 2007; 2 May Obesity Medical SABC3 2007, 5 March Stem cells eTV – Great 2007, 20 February Stem cell shortage Expectations Emission Pulsations 2002 Le sein dans tous ses etats TV (Léman Bleue) Radio Cape Talk 2017, 21 March Stem cells: the hype and Kirsten the hope Pretoria FM 2016, April CCR5 null stem cell bank Marelize Mare Talk Radio 702 and 2016, 19 January Stem Cells John Robbie show 567 Cape Talk Channel Islam 2015, 15 November Stem Cells Interview with Julie International Radio Ally - 66 -
Power FM 2015, 25 August Power perspective: Stem Interview with Cells Lawrence Tlhabane Talk Radio 702 and 2015, 25 August Stem Cells Interview with John 567 Cape Talk Matham Power FM 2015, 08 June Designer babies Interview with Tim Modise Classic FM 2015, 12 May Stem Cells and Human Interview with Genome Tamara Lepine- Williams CII Radio 2014, 30 August Stem Cells SAFm 2014, 05 August Stem Cells HealthMatters on 2014, 22 July Stem Cells Interview with Karen SAFm Key Smile94 FM 2014, 15 July Stem cells Interview with Bobby Brown Jamaican Nationwide 2013, 21 November Stem cells Radio: This Morning Show Tuks FM 2013, 3 & 5 August Stem cells: the hype and the hope Radio Junto 2013, 28 May Stem cell research and Interview with therapy Zwelibanzi Sisilana Radio Sonder Grense 2012, 22 November Treatment of spinal cord Interview with Metzi Monitor (news injuries using olfactory van der Merwe actuality program) ensheathing cells SAFM (repeated) as 2012, 1 November Stem cells well as the Swazi and Ndebele stations Radio Sonder Grense 2012, 25 October Treatment of mitochondrial Interview with Hanri Monitor (news disorders using Wondergrem actuality program) (pro)nuclear transfer Talk Radio 702 and 2012, 06 September Human Genome Interview with 567 Cape Talk Stephen Grootes Talk Radio 702 and 2012, 12 July Medical Malpractice Interview with Redi 567 Cape Talk Litigation Thabi Talk Radio 702 and 2012, 09 July Medical Malpractice Interview with Bruce 567 Cape Talk Litigation Whitfield The Money Show SAfm radio 2011, 03 May Stem Cells Interview with Karen Key SAfm radio 2009, 17 September Interview with Science Matters Christina Scott East Coast Radio 2006, 11 August Genetics of obesity Midrand Community 2006, 24 May Stem Cells Radio Radio Sonder Grense 2005, 24 May Beta sel groep oorplantings Interviewer Marisa de Monitor (news vir Diabetes 1: Klerk actuality program) bekostigbaar?
- 67 -
CONFERENCES, LECTURES AND SEMINARS (BY INVITATION)
1987 Sept. EMBO workshop on Extracellular Matrix and Cell Differentiation. Santa Margherita Ligure, Genoa (Italy). Endothelial cell migration and extracellular proteolysis.
1990 Aug. 13th Sigrid Jusélius Symposium on Cell-Matrix Contacts and Pericellular Proteolysis. Helsinki (Finland). Proteolytic balance and capillary morphogenesis.
1991 Jan. Swiss Institute for Experimental Cancer Research. Epalinges (Switzerland). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
1991 Jan. Jenkinson Lecturer, Department of Zoology and Sir William Dunn School of Pathology, Oxford University. Oxford (UK). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
1991 March International Symposium on Angiogenesis. St. Gallen (Switzerland). Proteolytic balance and capillary morphogenesis in vitro.
1991 June XIème Forum de Cancerologie de la Société Française du Cancer et de la Fédération National des Centres de Lutte Contre le Cancer. Paris (France). Plenary lecture: Angiogenèse et Cancer.
1991 Sept. International Society for Heart Research. 12th European Section Meeting. Leuven (Belgium). Proteolytic balance and capillary morphogenesis in vitro.
1991 Oct. 2nd Symposium on Growth, Differentiation and Pathology of Vascular Endothelium. Ringberg Castle (Germany). Angiogenesis in vitro: modulation of extracellular proteolysis and cell-extracellular matrix interactions.
1991 Nov. Ciba-Geigy Limited. Basel (Switzerland). Proteolytic balance and capillary morphogenesis in vitro.
1992 June 11th International Congress on Fibrinolysis. Copenhagen (Denmark). Proteolytic balance and in vitro morphogenesis.
1992 Sept. A New Understanding of the Role of Matrix Metalloproteinases in Tumor Biology, Upjohn Company/Brook Lodg. Kalamazoo (MI, USA). Proteolytic balance and morphogenesis of the microvasculature.
1992 Sept. Department of Cell Biology, New York University Medical Center. New York (USA). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
- 68 - 1992 Nov. VIIth International Symposium on the Biology of Vascular Cells. San Diego (CA, USA). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
1992 Nov. Department of Pathology, University of Washington. Seattle (WA, USA). Angiogenesis in vitro: cytokine interactions and extracellular proteolysis.
1993 June NATO Advanced Study Institute on Angiogenesis: Molecular Biology, Clinical Aspects. Rhodes (Greece). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
1993 Nov. Banbury Center conference on Mechanisms of Developmental and Tumor Angiogenesis, Cold Spring Harbor Laboratory. New York (USA). Angiogenesis in vitro: cytokine interactions and extracellular proteolysis.
1993 Nov. Department of Pathology, Yale University. New Haven (CT, USA). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1993 Nov. Swiss Connective Tissue Society Meeting. Geneva (Switzerland). Proteolytic balance and capillary morphogenesis in vitro.
1994 March Union des Sociétés Suisses de Biologie Expérimentale. Bern (Switzerland). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 April Growth Factor Club, Departement Forschung, Kantonsspital. Basel (Switzerland). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 April Max-Planck-Arbeitsgruppen für Rheumatologie. Erlangen (Germany). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 April Max-Planck-Institut für Physiologische und Klinische Forschung. Bad Nauheim (Germany). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 April European Kidney Research Forum, Kloster Banz. Erlangen/Nürnberg (Germany). Plenary lecture: Regulation of angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 Aug. VIIIth International Symposium on the Biology of Vascular Cells. Heidelberg (Germany). Angiogenesis in vitro: cytokine interactions and balanced proteolysis.
1994 Sept. Max-Delbrück-Centrum für Molekulare Medizin, Franz-Volhard-Klinik. - 69 - Berlin-Buch (Germany). Angiogenesis.
1994 Sept. Schering AG, Institute of Cellular and Molecular Biology. Berlin (Germany). Angiogenesis in vitro: mechanisms and modulators.
1994 Nov. Swiss Society for Oncology. Bern (Switzerland). Angiogenesis in vitro: mechanisms and modulators.
1995 Feb. Keystone Symposium on Tumor Cell Invasion and Motility. Tamarron (CO, USA). Angiogenesis: a balance between positive and negative regulators.
1995 April Celltech Therapeutics. Slough (UK). Angiogenesis: a balance between positive and negative regulators.
1995 May Finsen Laboratory. Denmark (Copenhagen). Angiogenesis: a balance between positive and negative regulators.
1995 May 2nd Franz-Volhard-Symposium on Mechanisms of Angiogenesis. Berlin-Buch (Germany). Angiogenesis: mechanisms and modulators.
1995 July Gordon Research Conference on Matrix Metalloproteinases. Proctor Academy. Andover (NH, USA). Angiogenesis: mechanisms and modulators.
1995 Sept. Institute for Molecular Pathology. Vienna (Austria). Angiogenesis: a balance between positive and negative regulators.
1995 Oct. 57th annual meeting of the Société Suisse d'Anatomie, d'Histologie et d'Embryologie. Geneva (Switzerland). Plenary lecture: Clinical applications of angiogenesis research: tilting the balance between positive and negative regulators.
1995 Nov. Boehringer Ingelheim International Conference on Angiogenesis and Anti- angiogenesis. Titisee (Germany). Angiogenesis: a balance between positive and negative regulators.
1996 April Workshop entitled "Angiogenesis: mechanistic insights and disease" at the 30th Annual Meeting of the European Society for Clinical Investigation. Interlaken (Switzerland). Angiogenesis: a balance between positive and negative regulators.
1996 Sept. Symposium entitled "Fallout healing: blood-borne endothelial stem cells", The Hope Heart Institute and Providence Medical Center. Seattle (WA, USA). Endothelial cell ontogeny and mechanisms of vascular formation.
1996 Sept. IXth International Vascular Biology Meeting. - 70 - Seattle (WA, USA). Angiogenesis-regulating cytokines in context.
1996 Sept. 78e réunion annuelle de la Société Suisse de Dermatologie et Vénérologie. Geneva (Switzerland). Régulation positive et negative de l'angiogenèse: de la biologie cellulaire aux applications cliniques.
1997 March Institut für Genetik, Forschungszentrum Karlsruhe. Karlsruhe (Germany). Angiogenesis: a balance between positive and negative regulators.
1997 May Novo-Nordisk. Copenhagen (Denmark). Manipulating angiogenesis: from basic science to the bedside.
1997 May Haartman Institute, University of Helsinki, Helsinki (Finland). Manipulating angiogenesis: from basic science to the bedside.
1997 Aug. Gordon Research Conference on Angiogenesis and Microcirculation. Salve Regina University. Newport (RI, USA). Balance and context: paradigms which reveal complexity in the regulation of angiogenesis.
1997 Sept. Philippe Laudat Conference on Biology and Physiopathology of Angiogenesis. Aix-les-Bains (France). Angiogenesis: a balance between positive and negative regulators.
1997 Dec. Institut d’Embryologie du CNRS et du Collège de France. Nogent Sur Marne (France). Balance and context: regulatory paradigms for angiogenesis.
1998 Feb. Sir William Dunn School of Pathology. Oxford (UK). Balance and context: regulatory paradigms for angiogenesis.
1998 Feb. 4th Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). What is angiogenesis: mechanisms of angiogenesis.
1998 March ImClone Systems, Inc. New York (NY, USA). Manipulating angiogenesis: from basic science to the bedside.
1998 March Keystone Symposium on Angiogenesis and Vascular Remodelling. Steamboat Springs (CO, USA). Balance and context: regulatory paradigms for angiogenesis.
1998 June AACR/APMIS conference on proteases and protease inhibitors in cancer. Nyborg (Denmark). Balance and context: regulatory paradigms for angiogenesis.
1999 Feb. 5th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). - 71 - Angiogenesis and mechanisms of vessel wall assembly.
1999 Feb. Société de Biologie. Paris (France). Angiogenèse et assemblage de la paroi vasculaire.
1999 April Journées Recherche Sciences de la Vie et de la Santé, Université Joseph Fourier, Grenoble I. Grenoble (France). Plenary lecture: Angiogenèse: de la biologie cellulaire aux applications cliniques.
1999 May Annual European Vascular Biology Association meeting: endothelial cell activation: inflammation and angiogenesis. Baden (Austria). Werner Risau memorial lecture: Angiogenesis and vessel wall formation: from cell biology to the clinic.
1999 May Laboratoire de biologie moleculaire et génie génétique, Faculté des Sciences, Université de Liège. Liège (Belgium). Angiogenesis and vessel wall assembly: from cell biology to the clinic.
1999 June Institute for Medical Radiobiology of the University of Zurich and the Paul Scherrer Institute Villigen (Switzerland) Angiogenesis and vessel wall assembly: mechanistic insights and therapeutic targets.
1999 July Oncology Workshop, Merck KGaA Darmstadt (Germany) Angiogenesis and vessel wall assembly: mechanistic insights and therapeutic targets.
1999 Aug. Transgène S.A. Strasbourg (France) Angiogenèse et morphogenèse de l’arbre vasculaire: de la biologie cellulaire aux applications cliniques.
1999 Sept. Molecular and Cellular Biology of Plasminogen Activation. Les Diablerets (Switzerland) The PA/plasmin system in PymT-induced vascular tumor formation.
1999 Oct. Journée rétine. Nyon (Switzerland) Angiogenèse et facteurs de croissance.
2000 Jan. IBC conference on Therapeutic Control of Angiogenesis. London (UK) Overview of angiogenesis concepts: exploring new opportunities for clinical development.
2000 Jan. 6th Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). Angiogenesis and mechanisms of vessel wall assembly.
2000 April Department of Clinical Research, University of Bern. - 72 - Bern (Switzerland). Manipulating angiogenesis: from cell biology to the clinic.
2000 Sept. XXVII Congress of the European Society for Artificial Organs. Lausanne (Switzerland). Plenary lecture: Mechanisms of angiogenesis: applications to the vascularization of artificial organs.
2000 Sept. XIth International Vascular Biology Meeting. Geneva (Switzerland). Plenary lecture: VEGF-C-mediated lymphangiogenesis promotes tumour metastasis.
2000 Oct. 9th Congress of the European Academy of Dermatology and Venerology. Geneva (Switzerland). Plenary lecture: Clinical applictions of angiogenesis research.
2001 Jan. 7th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). Cytokine regulation of vascular tree formation.
2001 Feb. 1st International workshop on new therapeutic targets in vascular biology. Geneva (Switzerland). Lymphangiogenesis and tumor metastasis.
2001 May Meeting of the “Hinterzartener Kreis für Krebsforschung/Cancer Research” organized by the Deutsche Forschungsgemeinschaft. Cadenabbia (Italy). Lymphangiogenesis and tumor metastasis.
2001 May Institute of Molecular Oncology, Tumor Biology Center. Freiburg (Germany). VEGF-C-mediated lymphangiogenesis promotes tumour metastasis.
2001 May 3rd Symposium on the Biology of Endothelial Cells. Pathophysiology of the endothelium: vascular and infectious diseases. Giessen (Germany). VEGF-C-mediated lymphangiogenesis promotes tumour metastasis.
2001 June EntreMed Inc. Rockville (MD, USA). VEGF-C-induced lymphangiogenesis: a novel therapeutic target for tumor metastasis.
2001 June The Derald H. Ruttenberg Cancer Center, Mount Sinai Medical Center. New York (NY, USA). Lymphangiogenesis and tumor metastasis.
2001 June ImClone Systems Inc. New York (NY, USA). VEGF-C-mediated lymphangiogenesis mediates tumor metastasis.
2001 June Swiss Institute for Applied Cancer Research. Oerlikon (Switzerland). Lymphangiogenesis and metastasis.
- 73 - 2001 July Merck KGaA. Darmstadt (Germany). Lymphangiogenesis and tumor metastasis.
2001 July XVIIIth Congress of the International Society on Thrombosis and Hemostasis. Paris (France). State of the art lecture: Extracellular proteolysis and angiogenesis.
2001 Sept. I.S.L. XVIII International Congress of Lymphology. Genova (Italy). Tumor lymphangiogenesis in Rip.VEGF-C transgenic mice.
2001 Nov. Department of Pathology, University of Bonn. Bonn (Germany). Lymphangiogenesis and tumor metastasis: myth or reality.
2001 Nov. PALM AG MicroLaser Systems workshop on laser capture microdissection. Bernried (Germany). VEGF-C-mediated lymphangiogenesis promotes tumor metastasis.
2002 Jan. Sir William Dunn School of Pathology. Oxford (UK). Lymphangiogenesis and tumor metastasis: myth or reality.
2002 Jan. 8th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). First presentation: Angiogenesis and vessel wall assembly. Second presentation: Cell-based delivery of angiogenic growth factors.
2002 Feb. Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis. Ventura (CA, USA). Proteolysis in angiogenesis and lymphangiogenesis.
2002 Feb. 8th Biennial Meeting of the International Society for Applied Cardiovascular Biology. St. Gallen (Switzerland). Cell-based delivery of angiogenic growth factors.
2002 June Angiogenesis: basic mechanisms and therapeutic implications. Monte Verita, Ascona (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 July Angiogenesis Platform, Novartis. Basel (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 Aug. Serono Pharmaceutical Research Institute. Geneva (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 Sept. Angiogenesis: molecular mechanisms and functional interactions. Kloster Seeon (Germany). VEGF-C-mediated lymphangiogenesis promotes tumor metastasis.
2002 Oct. 6ème Journée d'Interaction des Groupes de Recherche des Facultés de Médecine - 74 - de Genève et Lausanne. Changins (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 Nov. Novartis Foundation (prev. Ciba Foundation) symposium no. 256 on Inflammation and Cancer. London (UK). Lymphangiogenesis and tumor metastasis.
2002 Nov. Swiss Society for Oncology meeting on “Breast cancer: biology and therapy”. Lausanne (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 Nov. Austrian Vascular Biology Organization. Vienna (Austria). Plenary lecture: The lymphatic vascular system: a renaissance.
2003 Jan. “Onkologische Grundlagenforschung” seminar series, University of Basel. Basel (Switzerland). Lymphangiogenesis and tumor metastasis.
2003 Feb. New Therapeutic Targets in Vascular Biology. Geneva (Switzerland). Lymphangiogenesis and tumor metastasis.
2003 Feb. Signaling in breast cancer and new therapeutic approaches. Nice (France). Lymphangiogenesis and tumor metastasis.
2003 March 35th Annual Meeting of the Swiss Societies for Experimental Biology. Davos (Switzerland). Lymphangiogenesis and tumor metastasis.
2003 May Boehringer Ingelheim meeting on Lymphangiogenesis. Baden/Vienna (Austria). Lymphangiogenesis and tumor metastasis.
2003 June 2nd Institut Pasteur Euroconference on Angiogenesis. Paris (France). Lymphangiogenesis and tumor metastasis.
2003 June International Meeting on Angiogenesis in Cancer. Reykjavik (Iceland). VEGF-C-mediated lymphangiogenesis promotes tumor metastasis.
2003 Aug. Department of Medicine, Johannesburg General Hospital. Johannesburg (South Africa). Manipulating angiogenesis: from basic science to the bedside.
2003 Nov. 69. Jahresversammlung Schweizerische Gesellschaft für Pathologie. Ittingen (Switzerland). Lymphangiogenesis and tumor metastasis.
2003 Nov. Journées medico-chirurgicales d’hépatologie et de gastroenterologie. Geneva (Switzerland). Métastases lymphogènes des tumours digestives.
- 75 - 2003 Dec. Wallenberg Laboratory, Sahlgrenska University Hospital. Gothenburg (Sweden). The lymphatic vascular system: a renaissance.
2003 Dec. Institute of Pathology, University of Bern. Bern (Switzerland). Lymphangiogenesis and tumor metatsasis.
2004 March Gordon Research Conference on Molecular Mechanisms in Lymphatic Function and Disease. Ventura (CA, USA). Lymphangiogenesis and tumor metatsasis.
2004 Aug. Biomedicum Helsinki. Helsinki (Finland). Hemangiomas and vascular malformation: new insights into their pathogenesis and treatment.
2004 Aug. Regenerative Medicine. Turku (Finland). The lymphatic vascular system: a renaissance.
2004 Oct. Roche In Vitro Diagnostics Forum. Johannesburg (South Africa). Genes guide the way - a promise of new technology.
2004 Oct. Belgian Society for Cell and Developmental Biology. Liège (Belgium). Lymphangiogenesis and tumor metastasis.
2005 Feb. Roche Molecular Diagnostics. Cape Town (South Africa). Pharmacogenetics.
2005 June Roche 1st Central and Eastern European In Vitro Diagnostics Forum. Athens (Greece). Genes lead the way: a promise of new technology.
2005 Aug. Nelson R. Mandela School of Medicine, University of KwaZulu-Natal. Durban (South Africa). The power of pharmacogenetics.
2005 Nov. Merck KGaA. Darmstadt (Germany). Insights into the mechanisms of angiogenesis: identification of novel therapeutic targets.
2006 May University of Ulm, Department of Medicine. Ulm (Germany). Cell-based therapy in the heart – the South African potential.
2006 Aug. 44th Annual Congress of the South African Gastroenterology Society. Port Elizabeth (South Africa). The genetics of obesity.
2006 Sept. XXIXth International Congress of the International Society of Blood Transfusion. Cape Town (South Africa). State-of-the-art lecture: Stem cell plasticity. - 76 -
2006 Sept. Society for the Advancement of Blood Management Annual Meeting. Jersey City (NJ, USA). Plenary lecture: South African Blood Conservation Program.
2007 Feb. Biological Psychiatry Congress 2007. From Molecules to Mind: Bridging the Gap. Somerset West (South Africa). Amplichip CY450 genotype profiling: improving treatment outcomes in psychiatric disorders.
2007 May South African Medicolegal Society. Pretoria (South Africa). Stem cells: current reality and future promise.
2007 June Bioethics Forum on Public and Private Stem Cell Banking. Pretoria (South Africa). Public and private stem cell banking: scientific arguments.
2007 Aug. AfricaBio: Biotechnology and Stem Cell Research. Centurion (South Africa). Cell-based therapy in South Africa.
2007 Sept. South African division of the International Association for Dental Research. Centurion (South Africa). Stem cells: what are they and how will they affect dentistry in the future?
2007 Sept. Bio2Biz SA 2007. Cape Town (South Africa). Stem cells. Current reality and future promise.
2008 Jan. SASOM Bariatric Workshop. Pretoria (South Africa). Genetics and epigenetics of obesity: key points.
2008 July National Biotechnology Advisory Committee Workshop. Pretoria (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2008 Sept. Bio2Biz 2008. Johannesburg (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2008 Oct. International Physiotherapy Congress. Pretoria (South Africa). Stem cells: current reality and future promise.
2008 Oct. Biotechnology in Medical Research – Media Round Table (SAASTA/PUB). Cape Town (South Africa). Health Biotech in South Africa.
2009 Feb. College of Agriculture and Environmental Sciences, University of South Africa. Johannesburg (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2009 May California NanoSystems Institute (CNSI), University of California, Los Angeles. Los Angeles (CA, USA). - 77 - Bedside to bench: defining the market in health biotechnology in South Africa.
2009 May In Vivo and Cellular Molecular Imaging Center Seminar Series, Johns Hopkins University School of Medicine. Baltimore (MD, USA). Bedside to bench: defining the market in health biotechnology in South Africa.
2009 May The Human Tissue Regulatory Environment. Pretoria (South Africa). The Stem Cell Regulatory Environment in South Africa.
2009 July SA Bio Plan – Emory Goizueta Business School. Stellenbosch (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2009 Aug. Innov8 Pub @ Hub. Pretoria (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2009 Sept. Department of Jurisprudence, School of Law, University of South Africa. Pretoria (South Africa). The Stem Cell Regulatory Environment in South Africa: operating in a regulatory vaccuum.
2009 Sept. Bio2Biz. Durban (South Africa). Impediments to the establishment of stem cell technology in South Africa.
2009 Sept. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). 1. Bedside to bench - defining the market in health biotechnology in South Africa. 2. Cell-based thearpy.
2009 Nov. 31st South African National Blood Transfusion Congress. Johannesburg (South Africa). Sustainability strategies in public cord blood banking.
2009 Nov. Technology transfer in South Africa (SARIMA/WBI). Cape Town (South Africa). A meta-analysis of studies on tech transfer in South Africa.
2009 Nov. Stem Cells – Media Round Table (SAASTA/PUB). Durban (South Africa). Cell-based therapy.
2010 Feb. Steve Biko Centre for Bioethics, University of the Witwatersrand. Reproductive Health – Ethics and Law. Johannesburg (South Africa). Cord blood collection and banking.
2010 March South African Transplantation Society. 3rd Controversies in Transplantation Meeting. Mount Grace (South Africa). Human tissue legislation: revision of Chapter 8 of the NHA and associated regulations.
2010 March South African Genetics Society 21st Congress. Bloemfontein (South Africa). Genomic Sovereignty. - 78 -
2010 May Bestmed Annual General Meeting. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2010 Aug. Transplantation Indaba Cape Town (South Africa). Overview of stem cell principles and legislation.
2010 Aug. Faculty Day, Faculty of Health Sciences, University of Pretoria. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2010 Sept. NBAC national workshop on Feeding the Biotechnology Pipeline. Pretoria (South Africa). The regulatory environment and the new Bio-economy in South Africa.
2010 Oct. Human tissue use: medico-legal and ethical implications. Durban (South Africa). The Amendments to Chapter 8 of the National Health Act and Regulations thereto.
2010 Oct. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2010 Nov. Medi-Clinic Southern Africa Management Committee. Stellenosch (South Africa). Cell-based therapy.
2010 Nov. Biotechnology landscape in South Africa – Media Round Table (SAASTA/PUB). Cape Town (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2011 Jan. Muelmed Hospital Physiotherapy/Rehab Department. Pretoria (South Africa). Cell-based therapy.
2011 March University of Pretoria and the South African Paediatric Association. Update 2011. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2011 March Post-graduate Diploma in Transfusion Medicine. University of the Free State. Bloemfontein (South Africa). Cord blood stem cell banking.
2011 April The Nestle Nutrition Institute Africa and the Departnment of Human Nutrition (University of Pretoria) – 8th CNE. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2011 May Pan-African Ethics, Human Rights and Medical Law. Johannesburg (South Africa). The southern African Human Genome Programme: some ethical, legal and social issues.
2011 May 2nd Neuroscience Day, University of Pretoria. Pretoria (South Africa). Epigenetics in the Neurosciences. - 79 -
2011 July Department of Immunology, University of Cape Town. Cape Town (South Africa). Cord blood stem cell banking: a realistic option for South Africa.
2011 Aug. Department of Science and Technology. Pretoria (South Africa). Genomic sovereignty.
2011 Aug. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2011 Sept. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Cape Town (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2011 Oct. University of Limpopo. Polokwane (South Africa). Cell-based therapy.
2011 Oct. South African Society of Physiotherapy. Pretoria (South Africa). Cell-based therapy.
2011 Nov. Ethics Workshop, Faculty of Health Sceinces, University of Pretoria. Pretoria (South Africa). Ethical, legal and social issues of the Southern African Human Genome Programme.
2011 Nov. SAASTA/PUB Critical Thinker’s Forum on the Southern African Human Genome Programme. Cape Town (South Africa). Human Genome introductory lecture.
2012 Feb. Division of Human Genetics, NHLS and University of the Witwatersrand. Johannesburg (South Africa). Cell-based therapy.
2012 March NBAC National Workshop: Bioprospecting South Africa’s biodiversity: a driver for the new bioeconomy. Pretoria (South Africa). The human genome.
2012 June Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Grahamstown (South Africa). Lecture 1: Bedside to bench - defining the market in health biotechnology in South Africa. Lecture 2: Cell-based therapy.
2012 July Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Durban (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2012 August Legal aspects relating to the applications of biotechnology, College of Law, Unisa. Pretoria (South Africa). Human tissue legislation in South Africa – a need for self-regulation?
2012 Aug. Medical malpractice litigation seminar, Institute for Cellular and Molecular Medicine. & Sept. Pretoria (South Africa). - 80 - Medical malpractice litigation in South Africa.
2012 Sept. Sci-Enza Sci-Enza, in collaboration with Public Understanding of Biotechnology (PUB). Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2012 Sept. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2012 Oct. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Cape Town (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2012 Oct. 9th Expert Lecture, University of Pretoria. Pretoria (South Africa). Stem cells: current reality and future promise. https://www.youtube.com/watch?v=AeXqow7fcMk
2012 Nov. swissnexDay’12: Brain Circulation. Bern (Switzerland). Emigration des cerveaux.
2012 Nov. SAASTA/PUB Critical Thinker’s Forum on Stem Cells. Doornkloof (South Africa). Stem Cells introductory lecture.
2013 March 16th International Society of Radiolabelled Blood Elements Congress. Pretoria (South Africa). Stem Cell Research and Therapy: an Overview.
2013 May Vitalab Journal Club. Johannesburg (South Africa). Stem Cell Research and Therapy: an Overview.
2013 May 4th Annual PD Rose Plenary Lecture, Rhodes University. Grahamstown (South Africa). Stem Cells: the Hype and the Hope.
2013 May Institute for Food, Nutrition and Wellbeing, University of Pretoria. Pretoria (South Africa). We are what we eat – at the interface between molecular medicine and nutrition.
2013 June Otorinolaryngology journal club. Pretoria (South Africa). Medical malpractice litigation.
2013 June Obstetrics and Gynaecology meeting on medical malpractice and legal matters. Johannesburg (South Africa). Medical malpractice litigation.
2013 July Pretoria Boys High School. Pretoria (South Africa). Stem cells: the hype and the hope.
2013 August International Centre for Genetic Engineering & Biotechnology (ICGEB). Cape Town (South Africa). - 81 - Stem cells: the hype and the hope.
2013 August Faculty Day, Faculty of Health Sciences, University of Pretoria Pretoria (South Africa). The lymphatic tree: the often forgotten second vascular system.
2013 August Ethical and Legal Issues on Biobanking, College of Law, Unisa Pretoria (South Africa). Private versus public biobanks.
2013 Sept. International Association for Dental Research (SA Division) Annual Congress Kammeeldrift (South Africa). Stem cells: the hype and the hope.
2013 Sept. 41st Conference of the Physiology Society of Southern Africa Roode Vallei (South Africa). Stem cells: the hype and the hope.
2013 Sept. Postgraduate Diploma in Transfusion Medicine, University of the Free State Bloemfontein (South Africa). Lecture 1: Stem cells: the hype and the hope. Lecture 2: Human tissue legislation.
2013 Oct. The future and sustainability of biobanks in South Africa to support indigenous research. Sandringham (South Africa). SA National Health Act and biobanking.
2013 Oct. 15th Biennial Congress of the Southern African Society for Human Genetics. Sandton (South Africa). Lecture 1: Objectives and future medical relevance of the SAHGP. Lecture 2: Mesenchymal stem cells: adult stem cells with potentially wide therapeutic applications.
2013 Oct. Emerging Health Technologies Seminars, CSIR. Pretoria (South Africa). Stem cells: the hype and the hope.
2013 Oct. Launch of the DST/NRF SARChI Chair in Mathematical Models and Methods in Bioengineering and Biosciences. Pretoria (South Africa). Angiogenesis and lymphangiogenesis: importance in tumor growth and metastasis.
2013 Nov. Dept. of Molercular Medicine and Haematology, University of the Witwatersrand. Johannesburg (South Africa). Stem cells: the hype and the hope.
2013 Nov. Ethics Workshop, Faculty of Health Sceinces, University of Pretoria. Pretoria (South Africa). Medical malpractice litigation in South Africa.
2013 Nov. Seminar Day, Genomics Research Institute, University of Pretoria. Pretoria (South Africa). The Human Genome – a novel perspective.
2013 Nov. University of the West Indes, Mona Campus. Kingston (Jamaica). Angiogenesis and lymphangiogenesis – importance in tumor growth and metastasis. - 82 -
2013 Nov. University of Technology. Kingston (Jamaica). Angiogenesis and lymphangiogenesis – importance in tumor growth and metastasis.
2013 Nov. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus. Kingston (Jamaica). The Human Genome.
2013 Nov. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus. Kingston (Jamaica). Stem cells – current reality and furure promise.
2014 Feb. 2014 National Life Science Conference of the IEB. Johannesburg (South Africa). Stem cells – current reality and furure promise.
2014 August SASOG Gauteng North. Pretoria (South Africa). Sex determination and gender identity.
2014 August International Conference on Tissue Engineering and Regenerative Medicine. Pretoria (South Africa). Establishment of a sustainable public cord blood stem cell bank for South Africa.
2014 Sept. Consensus study on homosexuality. Bellagio (Italy). Sex determination and gender identity.
2014 Nov. Bridging Science, Business, and Politics: the Role of Responsible Leadership in Creating the Necessary Transition to a Sustainable Global Economy. Pretoria (South Africa). Sustainable outcomes in stem cell and genomics research - the role of responsible leadership.
2014 Nov. Opportunities and responsibilities in genomic and stem cell research in South Africa. Potchefstroom (South Africa). Building capacity to investigate the role of mitochondrial DNA variants in Black African populations.
2014 Nov. 3rd Worldwide Network for Blood and Marrow Transplantation workshop (in partnership with the WHO) Cape Town (South Africa). Human Tissue Legislation.
2014 Dec. CSIR course on Induced Pluripotent Stem Cell Technology. Pretoria (South Africa). 1. Stem cells in SA: history and current status 2. Stem cell legislation/ethics/clinical application
2014 Dec. Du Tissu Graisseux a la Cellule Souche: Medecine et Chirurgie Regenerative Geneva (Switzerland). Les possibilites therapeutiques des cellules souches en 2014.
2015 April NHLS Pathology Research and Development Congress. Johannesburg (South Africa). - 83 - Clinical translation of an HIV gene therapy.
2015 June Bioinnovation Day 2015. Lausanne (Switzerland). Rendering the immune system resistant to HIV.
2015 July Special interest group (Assisted reproduction/embryology). Johannesburg (South Africa). Gender and sexual diversity.
2015 August Diversity in Human Sexuality. Johannesburg (South Africa). Presentation on report: Diversity in Human Sexuality: Implications for Policy in Africa.
2015 August South African Society for Human Genetics, Young Researcher’s Forum 2015. Pretoria (South Africa). Communicating your science to peers and the public.
2015 August 16th Biennial Congress of the South African Society for Human Genetics. Pretoria (South Africa). The design of the SAHGP – it’s history and logistical issues.
2015 August Launch of the special SAMRC University Flagship Stem Cell Edition of the South African Journal of Bioethics and Law. Pretoria (South Africa). 1. Human tissue legislation in South Africa: focus on stem cell research and therapy. 2. Legislation governing pluripotent stem cells in South Africa
2015 August Annual SAMRC University Flagship Stem Cell Workshop. Pretoria (South Africa). Rendering the immune system resistant to HIV.
2015 Sept. First International Conference of the South African Tissue Bank Association. Irene (South Africa). Tissue banking and biobanking: research and innovation.
2015 Oct. Genomics Research Institute Symposium. Pretoria (South Africa). The Southern African Human Genome Programme.
2015 Nov. Southern African Society for Reproductive Medicine and Gynaecological Endoscopy, National Congress. Johannesburg (South Africa). Stem cells: the hype and the hope.
2015 Nov. 12th South African Stem Cell Transplantation Symposium. Johannesburg (South Africa). Debate: need for a cord blood bank in South Africa – argument for.
2016 Jan. Die NG Kerk en selfdegeslagverhoudings. Pretoria (South Africa). Sex determination and gender diversity.
2016 Jan. Institute for Infectious Diseases and Molecular Medicine, University of Cape Town. Cape Town (South Africa). Sex determination and gender diversity.
- 84 - 2016 Jan. University of Cape Town Biobanking Symposium. Cape Town (South Africa). What is a BioBank and what is the current status of BioBanking in SA today?
2016 March P5 Africa Congress. Cape Town (South Africa). Monogenic disorders (CF in particular) and the importance of exome sequencing in identifying novel variant in our genetically-diverse polulation.
2016 April Pharmacogenomics and Precision Medicine Congress. Cape Town (South Africa). Southern African Human Genome Programme (SAHGP). Introduction on the Programme aims and objectives.
2016 May SASOG Congress 2016. Sun City (South Africa). 1. Gender and sexual diversity. 2. Stem cells – the hype and the hope.
2016 June Science and Cocktails lecture series. Braamfontein (South Africa). Gender and sexual diversity. https://www.youtube.com/watch?v=BqBhuGQpOBY
2016 Sept. Student Affairs Services Dialogue, Unisa. Pretoria (South Africa). Gender and sexual diversity.
2016 Sept. Vitalab Fertility Symposium. Johannesburg (South Africa). Gender diversity.
2016 Oct. Advancing HIV Cure Research. Stellenbosch (South Africa). Rendering the immune system resistant to HIV.
2016 Oct. The Quiltbag Project Seminar, Unisa. Pretoria (South Africa). Sex, gender and molecular factors.
2016 Nov. South African Clinical Research Association. Midrand (South Africa). Export of DNA: Permit, ethics and MTA?
2017 Feb. Masters in Information Technology (Big Data Science), University of Pretoria. Pretoria (South Africa). Computational biology.
2017 March 4th International Conference on Responsible Leadership. Johannesburg (South Africa). 1. Understanding gender and sexual diversity and the need for responsible leadership. 2. Panel discussion: Diversity and inclusion in global teams and organizations.
2017 March Prostate cancer: at the interface between sexual diversity and clinical management. Pretoria (South Africa). Gender and sexual diversity.
- 85 - 2017 March Royal Scoiety of Obstetrica and Gynaecology World Congress 2017. Cape Town (South Africa). 1. Gender and sexual diversity. 2. Stem cells: the hype and the hope.
2017 March 22nd South African Science and Religion Forum. Pretoria (South Africa). Genetics and the possibility of changing the identity of being(s).
2017 May 6th Annual ARESA Research Ethics Seminar. Cape Town (South Africa). Exporting DNA – preventing exploitation and promoting innovation.
2017 June African Genomic Medicine Training Initiative. Continent wide programme. Week 8: Monogenic Disorders introduction.
2017 June South African Surgical Society Symposium. Pretoria (South Africa). Stem cells: the hype and the hope.
2017 August iSDG Assembly 2017. Shenzhen (China). Achieving sustainable healthcare through the application of technology-based solutions.
2017 Sept. South African Medico-legal Association. Paarl (South Africa). Hypoxic ischemic encephalopathy: a combined genomic and cell therapy approach.
2017 Sept. 12th Biennial O&G Update, 2017. Pretoria (South Africa). Hypoxic ischemic encephalopathy and cerebral palsy: a genomic approach.
2017 Nov. Genomics Research Institute Symposium 2017. Pretoria (South Africa). Research Ethics of Human Genetics/Genomics.
2018 March Ethics Workshop, Faculty of Health Sciences, University of Pretoria. Pretoria (South Africa). Gender and sexual diversity.
2018 April Experts for Interns: World Health Organization. Geneva (Switzerland). Achieving sustainable healthcare through the application of technology-based solutions.
2018 May International Society for Cell and Gene Therapies: Global Regulatory Perspectives. Montreal (Canada). Opportunities in cell and gene therapy in South Africa.
2018 October Grand Challenges Annual Meeting 2018. Berlin (Germany). The NESHIE project in South Africa.
2018 October Lunchtime Seminar: World Health Organization. Geneva (Switzerland).
Achieving sustainable healthcare through the application of technology-based solutions. - 86 -
2018 Dec. Launch of the ASSAf consensus study report on Human Genetics and Genomics in South Africa: ethical, legal and social implications. Pretoria (South Africa). Human Genetics and Genomics in South Africa: ethical, legal and social implications.
2019 Jan. TUKS Undergraduate Research Forum (TURF). Pretoria (South Africa). Personal career path – lessons learnt.
2019 March Department of Science and Technology. Pretoria (South Africa). ASSAf consensus study report on Human Genetics and Genomics in South Africa: ethical, legal and social implications.
2019 March Biosafety Symposium 2019 (Biosafety SA). Pretoria (South Africa). Ethical, legal & social implications of human genetics & genomics.
2019 April WHO Expert Meeting on Genomics and Genetic Disorders. Pretoria (South Africa). Keynote/Welcome and Introduction. Health Economics Analysis.
2019 May KRISP/UKZN Flagship talks. Durban (South Africa). ASSAf Consensus Study on Genetics and Genomics in South Africa.
2019 May South African Medical Association. Pretoria (South Africa). Cell and Gene therapy: new medicines on the horizon.
2019 May Indaba on Global Injustice in Sport. Johannesburg (South Africa). Gender and sexual diversity.
2019 June Ethics workshop: informed consent for standard and nonstandard clinical interventions. Pretoria (South Africa). Clinical usage of novel molecular technologies.
- 87 -
ABSTRACTS
Published abstracts
1. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Endothelial cell-matrix interactions in angiogenesis. Coll. Rel. Res. 8(6): 516, 1988.
2. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Proteolytic balance and capillary morphogenesis in vitro. J. Mol. Cell. Cardiol. 23 (Suppl. 5): S16, 1991.
3. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Regulation of capillary morphogenesis in vitro. J. Cell. Biochem. Suppl. 16F: 75, 1992.
4. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Proteolytic balance and in vitro morphogenesis. Fibrinolysis 6 (Suppl. 2): 31, 1992.
5. Pepper M.S., Wagner E., Fotsis T., Schweigerer L., Ferrara N., Risau W., Orci L., Vassalli J.-D. and Montesano R.: Angiogenesis: a balance between positive and negative regulators. J. Cell. Biochem. Suppl. 19B: 5, 1995.
6. Soriano J.V., Pepper M.S., Nakamura T., Orci L. and Montesano R.: Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. Experientia 51: A62, 1995.
7. Mandriota S.J., Seghezzi G., Vassalli J.-D., Montesano R., Mignatti P. and Pepper M.S.: Vascular endothelial growth factor modulates extracellular proteolytic activity in vascular endothelial cells. Experientia 51: A65, 1995.
8. Pepper M.S., Vassalli J.-D., Orci L. and Montesano R. Regulation of angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis. Kidney Int. 47(2): 659, 1995.
9. Zimrin A.B., Pepper M.S., Montesano R. and Maciag T. An antisense oligonucleotide to the notch ligand jagged promotes angiogenesis in bovine microvascular endothelial cells (BMEC) on collagen gels. FASEB J 10(6): A1094, 1996
10. Lucas, R., Sablon E., Echtenacher B., Ameloot P., Magez S., Juillard P., Pepper M.S., Vandenabeele P., Hofmeister R., Bosman F., Fransen L., Montesano R., Grau G.E. and De Baetseiler P. A mouse TNF mutein with reduced toxicity, but with equal tolerizing, anti-angiogenic and protective activities. Eur. Cytokine Netw. 7(2): 236, 1996.
11. Lucas, R., Lou J.N., Donati Y.R.A., Mandriota S.J., Decrind C., Pepper M.S., Monso-Hinard C., Moore M.W., Bluethmann H. and Grau G.E. Both TNF receptors are needed to mediate TNF-induced cytotoxicity in microvascular endothelial cells. Eur. Cytokine Netw. 7(2): 235, 1996.
12. Pepper M.S., Mandriota S.J., Vassalli J,-D., Orci L. and Montesano R. Angiogenesis: a balance between positive and negative regulators. Eur. J. Clin. Invest. 26 (Suppl. 1): A38, 1996.
13. Mandriota S.J., Menoud P.-A. and Pepper M.S. Regulation of vascular endothelial growth factor receptor 2/FLK-1 expression in vascular endothelial cells. Eur. J. Clin. Invest. 26 (Suppl. 1): A38, 1996.
14. Gorden D.L., Mandriota S.J., Montesano R. and Pepper M.S. Modulation of vascular endothelial growth factor expression in isolated islets of Langerhans. Eur. J. Clin. Invest. 26 (Suppl. 1): A39, 1996.
15. Zimrin A.B., Pepper M.S., Montesano R. and Maciag T. An antisense oligonucleotide to the Notch ligand Jagged promotes angiogenesis in bovine microvascular endothelial cells (BMEC) on collagen gels. FASEB J. 10(6): 547, 1996. - 88 -
16. Masouyé I., Pepper M.S., Saurat J.H., Veerkamp J.H., Siegenthaler G. Endothelial cells from human skin express epidermal fatty acid-binding protein (E-FABP). J. Invest. Dermatol. 107(2): C18, 1996.
17. Hagens G., Masoye I., Pepper M.S., Madsen P., Saurat J.H., Veerkamp J.H and Siegenthaler G. Endothelial cells from human blood capillaries also express the epidermal fatty acid-binding protein. J. Invest. Dermatol. 107(3): 25, 1996
18. Thommen R., Humar R., Misevic G., Pepper M.S. and Battegay E.J. PDGF-BB increases endothelial migration and cord movements during angiogenesis in vitro. Microcirculation 4: 143, 1997.
19. Lucas R., Holmgren L., Mandriota S.J., Jimenez B., Garcia I., Montesano R., Grau G.E., Shing Y. and Pepper M.S. Cytotoxicity of TNF versus angiostatin in microvascular endothelial cells in vitro. Eur. J. Surg. Oncol. 24: 224, 1998.
20. Miralbell R., Tolnay M., Bieri S., Sappino A.P., Probst A., Pizzolato G. and and Pepper M.S. Pediatric medulloblastoma: prognostic significance of MIB-1, p53, bcl-2, and von Willebrand immunoreactivity. Med. Ped. Oncol. 31: 229, 1998.
21. Olofsson B., Korpelainen E., Pepper M.S., Mandriota S.J., Kumar V., Aase K.A.Y., Gunji Y., Alitalo K. and Eriksson U. VEGF-B binds to VEGFR-1 and regulates plasminogen activator activity in endothelial cells. Mol. Biol. Cell 9 (Suppl 5): 114A, 1998.
22. March K.L., Nguyen A.T., Gurudutt V.V., Fineberg N., Mahomed Y., Sharp T., Aufiero T., Brown J. and Pepper M. Human pericardial fluid often displays potent angiogenic inhibitory activity in patients with cardiac ischemia. Circulation 100(18): 407, 1999.
23. Pepper M.S., Rosnoblet C. and Kruithof E.K.O. Synergistic induction of tPA by VEGF and bFGF and localization of tPA to Weibel-Palade bodies in bovine microvascular endothelial (BME) cells. Fibrinolysis Proteolysis 14 (Suppl. 1): 20, 2000.
24. Tille J.-C., Wood J., Mandriota S.J., Schnell C., Ferrari S., Mestan J. and Pepper M.S. VEGFR-2 tyrosine kinase inhibitors inhibit bFGF- and VEGF-induced angiogenesis in vivo and in vitro. J. Submicrosc. Cytol. Pathol. 32 (30): 456, 2000.
25. Nisato R., Tille J.-C., Joncycz A., Goodman S.L., and Pepper M.S. v3 and v5 function during angiogenesis. J. Submicrosc. Cytol. Pathol. 32(3): 435, 2000.
26. Alizadeh N., Pepper M.S. and Pittet B. A model of ulcer healing in the ischemic limb. J. Submicrosc. Cytol. Pathol. 32(3): 430, 2000.
27. Alizadeh N., Pittet B., Pyke C., Baetens D., Montandon D., Ezban M. and Pepper M.S. Active-site inactivated FVIIa (FVIIai) increases viability in a skin flap model of acute ischemia. J. Submicrosc. Cytol. Pathol. 32(3): 409, 2000.
28. Mandriota S.J., Jussila L., Jeltsch M., Compagni A., Prevo R., Banerji S., Huarte J., Baetens D., Montesano R., Jackson D., Orci L., Alitalo K., Christofori G. and Pepper M.S. VEGF-C-mediated lymphangiogenesis promotes tumour metastasis. J. Submicrosc. Cytol. Pathol. 32(3): 384, 2000.
29. Schlaudraff K.U., Pepper M., Ehrenburg I.V., Tkatchouk E.N., Montandon D. and Pittet B. Influence of intermittent hypoxia training on the survival of ischemic dorsal random skin flaps in the rat. Hypoxia Med. J. 9: 29, 2001.
30. Pepper M.S. Cell-based delivery of angiogenic growth factors. Cardiovasc. Pathol. 11: 8, 2002.
- 89 - 31. Podograbinska S., Velasco P., Detmar M., Pepper M., Jackson D. and Skobe M. Molecular profile of the lymphatic endothelium. Lymphatic Res. Biol. 1: 92, 2003.
32. Bochaton-Piallat M.L., Hao H., Verin V., Camenzind E., Pepper M.S. and Gabbiani G. Porcine coronary artery smooth muscle cells are phenotypically heterogeneous. Arterioscl. Thromb. Vasc. Biol. 23(5): A47, 2003
33. Mathe Z., Dupraz P., Bosco D., Bucher P., Zbinden M., Rinsch C., Thorens B., Berney T, Pepper M.S. Retroviral transduction of pancreatic beta-cells by VEGF-164 improves glycemic control in a syngeneic model of islet cell transplantation. Transplantation 76(4): S60-S61, 2003.
34. Wernert N., Okuducu A. and Pepper M.S. Ets 1 is expressed in capillary blood vessels but not in lymphatics. Pathol. Res. Practice. 200(4): 260, 2004
35. Mathe Z., Dupraz P., Zbinden M., Bosco D., Filo A., Bucher P., Rinsch C., Thorens B., Berney T, Pepper M.S. Regulated gene expression of VEGF-164 by pancreatic beta-cells improves revascularization and engraftment after transplantation. Diabetologia 47: A181, 2004.
36. Nisato R.E., Harrison J.A., Buser R., Orci L., Rinsch C., Montesano R., Dupraz P. and Pepper M.S. Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended lifespan. Anticancer Res. 24(5D): 3582, 2004.
37. Hao H., Geinoz A., Ropraz P., Verin V., Camenzind E., Pepper M.S, Sanchez J.C., Gabbiani G. and Bochaton-Piallat M.L. Heterogeneity of smooth muscle cell populations cultured from pig coronary artery. Cardiovasc. Pathol. 13(3, Supplement): S159-160, 2004.
38. Friedrichs N., Hahne J., Pepper M.S., Rommerscheidt-Fuss U., Buettner R., Stelzner F and Wernert N. Immunohistochemical quantification of lympf vessels, VEGF-C and VEGFR-3 in human sarcomas. Pathol. Res. Practice. 201(3): 204, 2005.
39. Rubbia-Brandt L., Terris B., Giostra E., Dousset B., Morel P. and Pepper M.S. Lymphatic vessel density and VEGF-C expression correlate with malignant behaviour in human pancreatic endocrine tumors. Modern Pathol. 18 (Suppl 1): 285A, 2005.
40. Rubbia-Brandt L., Terris B., Giostra E., Dousset B., Morel P. and Pepper M.S. Lymphatic vessel density and VEGF-C expression correlate with malignant behaviour in human pancreatic endocrine tumors. Lab. Invest. 85 (Suppl 1): 285A, 2005.
41. Ballmer-Hofer K., Suarez S.C., Hoffmann U., Pepper M. and Nisato R. Altered signalling of an inhibitory VEGF-A splice variant results from a defect in heparin binding: implications for angiogenesis in development and tissue repair. FEBS J. 272 (Suppl 1): 218, 2005.
42. Pepper M. AmpliChip CYP450 genotype profiling for improving treatment outcomes in psychiatric patients. S. Afr. J. Psychiatry 13(1): 33-34, 2007.
43. Ammar A., Muhammed R., Patel P., Salmi M., Pepper M., Nissato R., Paish E.C., Ellis I. and Martin S.G. The role of CLEVER-1 in breast tumour metastasis. Eur. J. Cancer Supplements 5(3): 27, 2007.
44. van der Merwe M.T., Logan M., Pieters J.H., Sammi Y. and Pepper M.S. Sustained weight loss after an 18-month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. J. Endocrinol. Metab. Diabetes S. Afr. 12(1): 46, 2007.
45. Van der Merwe T., Logan M., Pieters J., Sammi Y. and Pepper M. Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. Int. J. Obesity 31(S1):S116, 2007.
- 90 - 46. Ammar A., Mohammed R., Salmi M., Pepper M., Paish E., Ellis I., Patel P. and Martin S.G. Role of CLEVER-1 in breast cancer metastasis. Breast Cancer Res. 10 (Suppl 2): S19-S20, 2008.
47. Logan M.G., Pepper M.S., van der Merwe M.T. and Fetter G.K. Early changes following bariatric surgery in South Africa. 43rd SEMDSA Congress. Cape Town, South Africa. 12-15 April, 2008. J. Endocrinol. Metab. Diabetes South Afr. 13(1): 35, 2008.
48. Logan M., Pepper M.S. and van der Merwe M.T. Early changes following bariatric surgery in South Africa. Int. J. Obesity 32 (Suppl 1): S51, 2008.
49. Mabeta P. and Pepper M.S. Evaluation of the antiangiogenic effects of bleomycin in vitro. J. Physiol. Sci. 59 (Suppl 1): 322, 2009.
50. Dodgen T., Cromarty D., Fickl H. and Pepper M. CYP2D6 and CYP2C19: a comparison of direct versus predicted phenotyping in a South African population. Basic Clin. Pharmacol. Toxicol. 107(Supplement s1): 259, 2010.
51. Modarressi A., Pietramaggiori G., Alizadeh N., Pepper M.S., Bochaton-Piallat M.L., Hinz B. and Pittet, B. Myofibroblasts play a key role in delayed wound healing in ischemia. Br. J. Surg. 97 (Suppl 4): S29, 2010.
52. Alessandrini M., Beltchev E., Pool R. and Pepper MS. Evaluation of the AMLprofiler in the South African context: report on preliminary findings. Blood 122 (21): online only, 2013.
53. Mabeta P, Davis P.F. and Pepper M.S. mTOR/PI3k/Akt signaling pathway in tumor angiogenesis and therapeutic targeting. Anticancer Res. 34: 6042, 2014.
54. Theron A.E., Lafanechere L., Pepper M.S., Prudent R., Viallet J., Jackson C., du Rant C and Joubert A.M. Novel in silico-designed anti-cancer compounds: from in vitro exploration to potential clinical considerations. J. Cancer Sci. Ther. 6: 10, 2014.
55. Alessandrini M. and Pepper M. Priority pharmacogenetics for Africa: establishment of a pan-African initiative. Basic Clin. Pharmacol. Toxicol. 115: 169, 2014.
56. Myburgh R., Ivic S., Pepper M.S., Gers-Huber G., Li D., Audige A., Rochat M.A., Jaquet V., Regenass S., Salmon P., Krause K.H. and Speck R.F. Lentivector knock-down of CCR5 in hematopoietic stem cells confers functional and persistent HIV-1 resistance in humanized mice. Mol. Ther. 23 (Suppl 1): S178, 2015.
57. Kallmeyer K, Lévigne D., Pepper M.S., Pittet-Cuénod B. and Modarressi A. In vivo tracking of adipose- derived mesenchymal stromal cells during physiological wound repair. Plast. Reconstr. Surg. 5 (1S): 11- 12, 2016.
58. Naidoo A., Ramsuran A., Chirehwa M., Denti P., McIlleron H., Naidoo K., Yende-Zuma N., Singh R., Ngapu S., Pepper M., Chaudhry M. and Padayatchi N. The Effect of Genetic Variation in UGT1A and ABCB1 on Moxifloxacin Pharmacokinetics in South African Patients with Tuberculosis. Clinical Therapeutics 39 (8) Suppl: e44-e45, 2017.
59. Oloyo A.K. and Pepper M.S. Contrasting views on the role of mesenchymal stem cells in tumor progression: A systematic review. In: Proceedings of the AACR International Conference: New Frontiers in Cancer Research; 2017 Jan 18-22; Cape Town, South Africa. Philadelphia (PA): AACR; Cancer Res. 77(22 Suppl): Abstract nr B36, 2017.
Other abstracts
- 91 - 60. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Endothelial cell-extracellular matrix interactions in angiogenesis. Proceedings of the Symposium on Growth, Differentiation and Pathology of the Vascular Endothelium, Schloß Ringberg (Germany). 5-8 October 1988.
61. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Endothelial cell-matrix interactions and cell invasiveness in angiogenesis. Proceedings of the 19th meeting of the Federation of European Biochemical Societies, Rome (Italy). 2-7 July 1989.
62. Pepper M.S., Spray D.C., Chanson M., Montesano R. and Orci L.: Junctional communication is induced in migrating capillary endothelial cells. Proceedings of the meeting on Molecular and Cell Biology of Gap Junctions, Irsee (Germany). 18-23 July 1989.
63. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Angiogenesis in vitro: morphogenetic and invasive properties of endothelial cells. Proceedings of the meeting of the British Society for Cell Biology, Manchester (U.K.). 3-6 April 1990.
64. Vassalli J.-D., Wohlwend A., Belin D., Pepper M., Montesano R. and Orci L.: Cytokines in the control of extracellular proteolysis. Proceedings of the First International Congress on Inflammation, Barcelona (Spain). 17-22 June 1990.
65. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Proteolytic balance and capillary morphogenesis in vitro. International Symposium on Angiogenesis, St. Gallen, (Switzerland). 13-15 March 1990.
66. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Modulation of angiogenesis in vitro. International Symposium on Angiogenesis, St. Gallen, (Switzerland). 13-15 March 1990.
67. Pepper M.S., Vassalli J.-D., Orci L. and Montesano R.: Angiogenesis in vitro: modulation of extracellular proteolysis and cell-extracellular matrix interactions. Proceedings of the 2nd Symposium on Growth, Differentiation and Pathology of Vascular Endothelium, Ringberg Castle (Germany). 16-19 October 1991.
68. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis. Proceedings of the VIIth International Symposium on the Biology of Vascular Cells, San Diego (California, USA). 10-14 November 1992.
69. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis. Proceedings of the NATO Advanced Study Institute on Angiogenesis: Molecular Biology, Clinical Aspects, Rhodes (Greece). 16-27 June 1993.
70. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Role of growth factors and extracellular matrix in angiogenesis and epithelial morphogenesis. Proceedings of the International Symposium on Developmental Endocrinology, Geneva (Switzerland). 30 September - 2 October 1993.
71. Fotsis T., Pepper M., Adlercreutz H., Hase T., Montesano R. and Schweigerer L. Genistein and angiogenesis inhibition. Proceedings of the 1st International Symposium on the role of Soy in Preventing and Treating Chronic Disease, Mesa (Arizona, USA). 20-23 February 1994.
72. Adlercreutz H., Fotsis T., Schweigerer L., Pepper M., Attalla H., Zhang Y., Wähälä C., Montesano R., Nawroth P.P. and Hase T.: Isoflavonoids and 2-methoxyestradiol: inhibitors of tumor cell growth and angiogenesis. Proceedings of the 85th AACR Annual Meeting "Novel Strategies in Chemical Chemoprevention of Cancer", San Francisco (California, USA). 10-13 April 1994.
73. Pepper M.S., Vassalli J.-D., Orci L. and Montesano R. Angiogenesis in vitro: cytokine interactions and balanced proteolysis. Proceedings of the VIIIth International Symposium on the Biology of Vascular Cells, Heidelberg (Germany). 30 August - 4 September 1994.
- 92 - 74. Fotsis T., Pepper M. Aktas E., Joussen A., Kruse F., Adlercreutz H., Hase T., Montesano R. and Schweigerer L.: Inhibitors of angiogenesis in human urine. Proceedings of the NATO Advanced Study Institute on Molecular Cellular and Clinical Aspects of Angiogenesis Porto Carras, Halkidiki (Greece). 16- 27 June, 1995.
75. Montesano R., Vassalli J.-D., Orci L. and Pepper M.S.: Endothelial and tubular morphogenesis. XIIIth International Congress of Nephrology, Madrid (Spain). 2-6 July, 1995.
76. Fotsis T., Pepper M., Aktas E., Joussen A., Kruse F., Adlercreutz H., Hase T., Montesano R. and Schweigerer L.: Dietary inhibitors of angiogenesis. Proceedings of the 11th IFCC European Congress of Clinical Chemistry, Tampere (Finland). 2-7 July, 1995.
77. Pepper M.S., Wagner E.F., Mandriota S.J., Vassalli J,-D., Orci L. and Montesano R. Angiogenesis: a balance between positive and negative regulators. Proceedings of the Boehringer Ingelheim International Conference on Angiogenesis and Anti-angiogenesis, Titisee (Germany). 1-5 November, 1995.
78. Pepper M.S., Montesano R. Mandriota S.J., Orci L. and Vassalli J.-D. Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis. Proceedings of the American Association for Cancer Research conference on Proteases and Protease Inhibitors in Cancer, Panama City (FL, USA). 1-5 March, 1996.
79. Hagens G., Masouyé I., Pepper M.S., Madsen P., Saurat J.H., Veerkamp J.H., Siegenthaler G. Endothelial cells from human blood capillaries also express the epidermal fatty acid-binding protein. Proceedings of the 25th meeting of the European Society for Dermatological Research, Amsterdam, The Netherlands. 28 September - 1 October, 1996.
80. Montesano R., Soriano J.V., Pepper M.S., Orci L. Induction of epithelial branching tubulogenesis in vitro. Proceedings of the 9th Conference of the International Society of Development, Cell Differentiation and Cancer, Pisa, Italy. 28 September - 2 October, 1996.
81. Lucas R., Lou J.N., Mandriota S., Pepper M., Suter P.M., Bluethmann H. and Grau G. TNF cytotoxicity in pulmonary microvascular endothelial cells in the presence versus absence of transcriptional inhibitor. Proceedings of the 29th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Geneva, Switzerland. 20-21 March 1996.
82. Pepper M.S. and Montesano R. Manipulating angiogenesis: from basic science to the bedside. Proceedings of the 29th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Geneva, Switzerland. 20-21 March 1996.
83. Mandriota S.J. and Pepper M.S. Regulation of vascular endothelial growth factor (VEGF) and VEGF receptor expression in vascular endothelial cells. Proceedings of the 29th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Geneva, Switzerland. 20-21 March 1996.
84. Tenan M., Diserens A.C., El Atifi M., Brunet J.F., Albertoni M., Fulci M., de Tribolet N., Feige J.J., Pepper M. and Van Meir E.G. Overexpression of thrombospondin-1 is anti-tumorigenic in glioblastoma. Proceedings of the 12th International Conference on Brain Tumour Research and Therapy, Keble College, Oxford, U.K. 20-23 September, 1997.
85. Pepper M.S. Angiogenesis. Proceedings of the 4th local drug delivery meeting and cardiovascular course on radiation and molecular strategies, Geneva, Switzerland. 26-28 February, 1998.
86. Bochaton-Piallat M.-L., Gabbiani G. and Pepper M.S. Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Proceedings of the 4th local drug delivery meeting and cardiovascular course on radiation and molecular strategies, Geneva, Switzerland. 26-28 February, 1998.
- 93 - 87. Lucas R., Holmgren L., Mandriota S.J., Jimenez B., Garcia I., Grau G.E., Shing Y. and Pepper M.S. Angiostatin induces apoptosis in endothelial cells. Proceedings of the 30th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Lausanne, Switzerland. 5-6 March 1998.
88. Pepper M.S. Balance and context: regulatory paradigms for angiogenesis. Proceedings of the Keystone Symposium on Angiogenesis and Vascular Remodeling, Steamboat Springs, CO, USA. 28 March - 3- April, 1998.
89. Cavallaro U., Wu Z., Pepper M.S., Montesano R. and Soria M.R. Crosstalk between angiogenic growth factors in the migration of vascular cells. Proceedings of the Keystone Symposium on Angiogenesis and Vascular Remodeling, Steamboat Springs, CO, USA. 28 March - 3-April, 1998.
90. Mandriota S.J. and Pepper M.S. Regulation of angiogenesis by interactions between positive and negative regulators. Proceedings of the Keystone Symposium on Angiogenesis and Vascular Remodeling, Steamboat Springs, CO, USA. 28 March - 3 April, 1998.
91. Pepper M.S. Balance and context: regulatory paradigms for angiogenesis. Proceedings of the AACR and APMIS meeting on Proteases and Protease Inhibitors in Cancer, Nyborg Strand, Denmark. 14-18 June, 1998.
92. Mandriota S.J and Pepper M.S. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Proceedings of the Xth International Vascular Biology Meeting, Cairns, Australia. 23-27 August, 1998.
93. Bochaton-Piallat M.-L., Gabbiani G. and Pepper M.S. Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Proceedings of the Xth International Vascular Biology Meeting, Cairns, Australia. 23-27 August, 1998.
94. Sleeman J. P., Steffen A., Mandriota S.J., Krishnan J. and Pepper, M.S. Lymphangiogenic factors VEGF- C and VEGF-D are expressed by tumors. Proceedings of the 5th Franz Volhard Symposium entitled “Twigs and Branches - Tube Formation and Branching in the Cardiovascular System", Berlin (Germany), 3-6 September, 1998.
95. Pepper M.S. Angiogenesis and mechanisms of vesselwall assembly. Proceedings of the 5th International Local Drug Delivery meeting and cardiovascular course on Radiation and molecular strategies, Geneva, Switzerland. 31 January - 2 February, 1999.
96. Gabbiani G., Pepper M.S. and Bochaton-Piallat M.-L. Molecular and cellular mechanisms: plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Proceedings of the 5th International Local Drug Delivery meeting and cardiovascular course on Radiation and molecular strategies, Geneva, Switzerland. 31 January - 2 February, 1999.
97. Quinodoz P., Pittet B., Rinsch C., Aebischer P., Montandon D. and Pepper M.S. Local delivery of bFGF by encapsulated transfected C2C12 myoblasts improves skin flap survival in the rat. Proceedings of the 12th Congress of the International Confederation for Plastic, Reconstructive and Aesthetic Surgery. San Francisco, CA, U.S.A. 27 June - 2 July, 1999.
98. Quinodoz P., Pittet B., Pepper M.S., Rinsch C., Aebischer P. and Montandon D. Local delivery of bFGF nd by encapsulated transfected C2C12 myoblasts improves skin flap survival in the rat. Proceedings of the 2 European appointed 35th National Congress of the Swiss Society of Plastic Surgery under the patronage of ESPRAS. St. Gallen, Switzerland. 2-4 September, 1999.
99. Alizadeh N., Pepper M. and Pittet B. Skin flap ischemia: a morphological and physiological study in the rat. Proceedings of the 2nd European appointed 35th National Congress of the Swiss Society of Plastic Surgery under the patronage of ESPRAS. St. Gallen, Switzerland. 2-4 September, 1999.
- 94 - 100. Tacchini-Cottier F., Ody C., Sabapathy K., Belin D., Wagner E.F. and Pepper M.S. The PA/plasmin system in PymT-induced vascular tumor formation. Les Diablerets, Switzerland. 4-9 September, 1999.
101. Alizadeh N., Pepper M.S., Montandon D., Bochaton-Piallat M.L., Gabbiani G., and Pittet B. L’impact de l’ischémie sur la cicatrisation. Proceedings of the Journée des jeunes plasticiens of the Société Francaise de Chirurgie Plastique Réconstructrice et Esthétique. Paris, France. 20 January, 2001.
102. Alizadeh N., Pittet B., Pyke C., Montandon D., Ezban M., and Pepper M.S. Le FVIIai améliore la survie des lambeaux cutanés. Proceedings of the Journée des jeunes plasticiens of the Société Francaise de Chirurgie Plastique Réconstructrice et Esthétique. Paris, France. 20 January, 2001.
103. Pepper M.S. Cytokine regulation of vascular tree formation. Proceedings of the 7th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva, Switzerland. 25-27 January, 2001.
104. Mandriota S.J., Jussila L., Jeltsch M., Compagni A., Baetens D. Prevo R., Banerji S., Huarte J., Montesano R., Jackson D., Orci L., Alitalo K., Christofori G. and Pepper M.S. VEGF-C-mediated lymphangiogenesis promotes tumour metastasis. Proceedings of the 3rd Symposium on the Biology of Endothelial Cells. Giessen, Germany. 24-26 May, 2001.
105. Alizadeh N., Pittet B., Pyke C., Baetens D., Montandon D., Ezban M. and Pepper M.S. Inactivated factor VII (FVIIai) increases viability of random skin flaps. An experimental study. Proceedings of the 12th Annual Meetng of the European Association of Plastic Surgeons. Helsinki, Finland. 31 May - 2 June, 2001.
106. Pittet B., Quinodoz P., Alizadeh N., Schlaudraff K., Montandon D. and Pepper M. How can we help acute ischemic tissue to survive? Physiopathological study of the onset of tissular necrosis in an ischemic falp model in the rat. Proceedings of the 37ème Congrès Annuel de la Société Suisse de Chirurgie Plastique, Reconstructive et Esthétique. Geneva, Switzerland. 7-8 September, 2001.
107. Schlaudraff K., Pepper M., Ehrenburg I.O., Tkatchouk E.O., Montandon D. and Pittet B. Improvement of the survival of ischemic dorsal skin flaps in the rat by means of normobaric intermittent hypoxia training. Proceedings of the 37ème Congrès Annuel de la Société Suisse de Chirurgie Plastique, Reconstructive et Esthétique. Geneva, Switzerland. 7-8 September, 2001.
108. Alizadeh N., Pepper M.S., Montandon D., Bochaton-Piallat M.L., Gabbiani G. and Pittet B. Impact of persistent lower limb ischemia on wound healing. Proceedings of the 37ème Congrès Annuel de la Société Suisse de Chirurgie Plastique, Reconstructive et Esthétique. Geneva, Switzerland. 7-8 September, 2001.
109. Alizadeh N., Pepper M.S., Montandon D., Bochaton-Piallat M.L., Gabbiani G. and Pittet B. Impact of persistent lower limb ischemia on wound healing. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001.
110. Pittet B., Rinsch C., Quinodoz P., Baetens D., Alizadeh N., Schlaudraff K.U., Montandon D., Aebischer P. and Pepper M.S. Tissue necrosis and its modulation by local release of cytokines in a rat ischemic skin flap model. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001.
111. Schlaudraff K.U., Pepper M.S., Montandon D. and Pittet B. Normobaric intermittent hypoxia training increases the survival of ischemic random dorsal skin flaps in the rat. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001.
112. Alizadeh N., Pittet B., Pyke C., Baetens D, Montandon D., Ezban M. and Pepper M.S. Active-site inactivated FVIIa (FVIIai) increases survival in a rat ischemic skin flap model. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001. - 95 -
113. Pepper M.S. and Wernert N. VEGF-C-mediated lymphangiogenesis promotes tumor metastasis. Proceedings of the PALM AG MicroLaser Systems workshop on laser microdissection technology. Bernried, Germany, 15-16 November, 2001.
114. Pepper M.S. Angiogenesis and vessel wall assembly. Proceedings of the 8th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva, Switzerland, 31 January – 2 February, 2002.
115. Pepper M.S. Cell-based delivery of angiogenic growth factors. Proceedings of the 8th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva, Switzerland, 31 January - 2 February, 2002.
116. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the meeting on Angiogenesis: basic mechanisms and therapeutic implications. Monte Verita (Ascona), Switzerland, 2-7 June, 2002.
117. Pepper M.S. Lymphangiogenesis and tumour metastasis. Proceedings of the Novartis Foundation (prev. Ciba Foundation) Symposium no. 256 on Inflammation and Cancer. London, U.K., 11-14 November, 2002.
118. Schlaudraff K.U., Pepper M., Ehrenburg I., Tkatchouk E., Montandon D. and Pittet B. Intracutaneous oxygen concentration in normal and ischemic skin is increased after intermittent hypoxia training. Proceedings of the 13th International Hypoxia Symposium. Banff Mountain Centre, Banff, Alberta, Canada, 19-22 February, 2003.
119. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the 35th Annual Meeting of the Swiss Societies for Experimental Biology. Davos, Switzerland, 19-21 March, 2003.
120. Bochaton-Piallat M.L., Hao H., Verin V., Camenzind E., Pepper M.S., Gabbiani G. Porcine coronary artery smooth muscle cells are phenotypoically heterogenous. Proceedings of the 4th Annual AHA Conference on Atherosclerosis, Thrombosis and Vascular Biology. Washington DC, USA, 8-10 May, 2003.
121. Schlaudraff K.-U., Pepper M., Ehrenburg I.V., Tkatchouk E.N., Montandon D., Pittet B. Impact of intermittent hypoxia training on intracutaneous oxygen concentration in normal and ischemic skin. Proceedings of the 5th International conference on “Hypoxia in Medicine”. Innsbruck, Austria, 26-28 September 2003.
122. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the 2nd Institut Pasteur Euroconference on Angiogenesis. Paris, France, 19-20 June, 2003.
123. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the International Meeting on Angiogenesis in Cancer. Reykjavik, Iceland, 26-28 June, 2003.
124. Podograbinska S., Braun P., Velasco P., Kloos B., Pepper M.S. and Skobe M. Molecular characterization of lymphatic endothelial cells. Proceedings of the International Meeting on Angiogenesis in Cancer. Reykjavik, Iceland, 26-28 June, 2003.
125. Schlaudraff K.U., Pepper M., Ehrenburg I.V., Tkatchouk E.N., Montandon D., Pittet B. Modulation of intracutaneous oxygen concentration by intermittent hypoxia training : implications for flap survival. Proceedings of the 7th European Conference of Scientists and Plastic Surgeons. Geneva, Switzerland, 19- 20 September, 2003.
126. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the 69. Jahresversammlung Schweizerische Gesellschaft für Pathologie. Ittingen, Switzerland, 6-8 November, 2003.
- 96 - 127. Pepper M.S. Métastases lymphogènes des tumeurs digestives. Proceedings of the Journées medico- chirurgicales d’hépatologie et de gastroenterologie. Geneva, Switzerland, 27-28 November, 2003.
128. Mahajan A.L., Tenorio X., Schlaudraff K.U., Pepper M.S., Baetens D., Montandon D. and Pittet B. New therapeutic intervention with rNAPc2 curbs progression of the burn wound. Poceedings of the XXIXth Sir Peter Freyer Meeting, Galway, Ireland. 3 September, 2004.
129. Pepper M.S. Genes guide the way - a promise of new technology. Proceedings of the Roche In Vitro Diagnostics Forum. Johannesburg (South Africa). 4 October, 2004.
130. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the Autumn meeting of the Belgian Society for Cell and Developmental Biology. Liège (Belgium). 16 October, 2004.
131. Henrichot E., Juge-Aubry C.E., Nisato R., Wohlwend A., Pernin A., Velebit V., Pepper M.S., Meda P. and Meier C.A. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Proceedings of the Société Suisse d'Endocrinologie et Diabétologie, Bern, Switzerland. November 2004.
132. Alizadeh N., Pepper M.S., Alfo K., Montandon D., Gabbiani G., Bochaton-Piallat M.-L. and Pittet B. Persistent ischemia impairs myofibroblast development in wound granulation tissue. A new model of delayed wound healing. Switzerland. November 2004.
133. Tenorio X., Schlaudraff K.-U., Pittet B., Baetens D. and Pepper M.S. Application of rNAPc2 reduces secondary aggravation of burn wounds. Proceedings of the 49th Congrés nationale de la société francaise de chirurgie plastique reconstructice et esthétique. Paris, France. 22-24 November, 2004.
134. Tenorio X., Schlaudraff K.-U., Pittet B., Baetens D. and Pepper M.S. Application of rNAPc2 reduces secondary aggravation of burn wounds. 41ème Congrès annuel de la société suisse de chirurgie plastique, reconstructrice et esthétique. Bienne, Switzerland. 30 September - 1 October, 2004.
135. Mahajan A.L., Tenorio X., Schlaudraff K.U., Pepper M.S., Baetens D., Montandon D. and Pittet B. Progressive tissue injury in burns is reduced by rNAPc2. Poceedings of the British Association of Plastic Surgeons Meeting, London, UK. December, 2004.
136. Tenorio X, Schlaudraff K.-U., Mahajan A.L., Pepper M.S., Montandon D., Pittet P. Application of rNAPc2 reduces secondary aggravation of burn wounds. 8th European Conference of Scientists and Plastic Surgeons (ECSAPS). Munich (Germany). 15-16 October, 2004.
137. Mathe Z., Dupraz P., Zbinden M., Bosco D., Bucher P., Rinsch C., Thorens B., Berney T. and Pepper M.S. VEGF-A overexpression improves islet cell revascularization and glycemic control after transplantation. American Transplant Congress, Seattle (WA, USA). May, 2005.
138. Mahajan A.L., Schlaudraff K.U., Tenorio X., Pepper M.S., Baetens D., Montandon D. and Pittet B. Progressive tissue injury in burns is reduced by rNAPc2. Proceedings of the British Burns Association (BBA) meeting, York, UK, April 2005.
139. Pepper M.S. Genes guide the way – the promise of new technology. Proceedings of the In Vitro Diagnostics Forum, Athens (Greece), 8-10 June 2005.
140. Mabeta P., Davis P.F. and Pepper M.S.: In vitro inhibition of angiogenesis by interferon alpha and bleomycin. Nature Biotechnology Winter Symposium on Angiogenesis in Cancer and Vascular Disease. Miami Beach, Florida (USA) 4-8 February 2006.
141. Schlaudraff K.-U., Mahajan A.L., Tenorio X., Pepper M.S., Montandon D. and Pittet B. Secondary aggravation of burn wounds and its detrimental influence on post burn sequelae – an underestimated clinical phenomenon? Abstract submitted for the EURAPS-meeting 2006.
- 97 - 142. Pepper MS. The genetics of obesity. Proceedings of the 44th Annual Congress of the South African Gastroenterology Society. Post Elizabeth, South Africa. August 6-9, 2006.
143. Nisato R.E., Tille J.-C., Baetens D., Sutter E., Orci L., Pytowski B. and Pepper M.S. Role of VEGFRs -1, - 2 and -3 in VEGF-C-induced lymphangiogenesis and in lymphatic-mediated metastases in Rip1Tag2:Rip1VEGF-C mice. Proceedings of the Gordon Research Conference on "Molecular Mechanisms In Lymphatic Function & Disease", Les Diablerets, Switzerland. 3-8 September, 2006.
144. van der Merwe M.T., Logan M., Pieters J.H., Sammi Y. and Pepper M.S. Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. 15th European Congress on Obesity, Budapest, Hungary. April 22-25, 2007.
145. van der Merwe M.T., Logan M., Pieters J.H., Sammi Y., Pepper M.S. Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. 42nd SEMDSA Congress. Bloemfontein, South Africa. 30 June – 2 July, 2007.
146. Hochfeld W., Asfaha S., Durandt C. and Pepper M.S. Utilization of the Roche Amplichip Platform For Pre-Prescription Genotyping. The 2007 University of Pretoria, School of Medicine, Faculty of Health Sciences Basic Sciences Research Day. Pretoria, South Africa. 15 August 2007.
147. Hochfeld W., Asfaha S., Durandt C. and Pepper M.S. Utilization of the Roche Amplichip Platform For Pre-Prescription Genotyping. The 2007 Pharmacology and Toxicology Congress, The South African Pharmacology Society (SAPS). North West Province, South Africa. 2-5 October 2007.
148. Mabeta P. Pepper M.S. The effect of Paclitaxel on neovessel formation in vitro. 35th PSSA congress, Muldersdrift, South Africa, 9-12 September 2007.
149. Mabeta P. Pepper M.S. Induction of in vitro angiogenesis in bovine endothelial cells and the effect of Paclitaxel on neovessel formation. Faculty Day, Faculty of Veterinary Sciences, University of Pretoria, 3rd September 2007.
150. Mabeta P., Davis P.F. and Pepper M.S.: Assessment of the effects of bleomycin on human haemangioma and angiogenesis in vitro. Faculty Day, Faculty of Health Sciences, University of Pretoria, 15th August 2007.
151. Dodgen T., Hochfeld W., Asfaha S., Durandt C. and Pepper M.S. Utilization of the Roche Amplichip platform for pre-prescription genotyping. 20th Biennial South African Genetics Society (SAGS) Congress. Pretoria, 27-29 March, 2008.
152. Mabeta P. and Pepper M.S. 2-Methoxyestradiol inhibits angiogenesis in vitro. 46th Annual Conference of the Microscopy Society of Southern African. Gaborone, Botswana, 23-25 July 2008.
153. Dodgen T.M., Cromarty A.D. and Pepper M. Phenotyping of CYP450-mediated drug metabolism in a demographically representative sample of the South African population. ChromSAAMS (Chromatography and Mass Spectrometry Divisions of the South African Chemical Institute), Bela Bela, South Africa. 12-15 October 2008.
154. Pepper M.S. Stem cells: current reality and future promise. International Physiotherapy Congress. Pretoria, South Africa. 6-8 October, 2008.
155. Skeen M. and Pepper M.S. Stem cell therapy for spinal cord injury – a retrospective analysis of patients in South Africa. 7th South African Symposium on Haematopoietic Stem Cell Transplantation. Johannesburg, South Africa. 30-31 January, 2009.
156. Thompson D and Pepper M.S. Flow cytometric analysis of stem cells derived from umbilical cord blood in South Africa. 7th South African Symposium on Haematopoietic Stem Cell Transplantation. Johannesburg, South Africa. 30-31 January, 2009. - 98 -
157. Flister M.J., Wilber A., Hall K.L., Iwata C., Miyazono K., Nisato R.E., Pepper M.S., Zawieja D.C and Ran S. VEGFR-3 and Prox1 are elevated by NF-kB during inflammatory angiogenesis. 100th Annual Meeting of the American Association for Cancer Research. Denver (CO), USA. 18-22 April, 2009.
158. Mabeta P. and Pepper M.S. Bleomycin inhibits angiogenesis and induces apoptosis in cultured bovine microvascular endothelial cells. 17th Conference of the International Federation of Associations of Anatomists (IFAA), Cape Town, South Africa, 16-19 August 2009.
159. Dodgen T.M, Cromarty A.D. and Pepper M.S. Pre-prescription genotyping of CYP2D6 and CYP2C19 in a demographically representative group of the South African population. Faculty Day, Faculty of Health Sciences, University of Pretoria, 19 August 2009.
160. Eloff A., van Staden C.W., Dodgen T.M., Mataboge C., Roos J.L. and Pepper M.S. Cytochrome P450 2D6 Polymorphisms in Weight Gain and Movement Disorders Associated with Risperidone: A Pilot Study. Faculty Day, Faculty of Health Sciences, University of Pretoria, 19 August 2009.
161. Dodgen T.M., Cromarty A.D., Fickl H. and Pepper M.S. Genotype vs. phenotype and the allelic variation of CYP2D6 and CYP2C19 in a demographic sample of the South African population. International Congress on Pharmaceutical and Pharmacological Sciences, North-West University, 23-26 September 2009.
162. Pepper M.S. Sustainability strategies in public cord blood banking. 31st South African National Blood Transfusion Congress, Johannesburg, 15-18 November 2009.
163. Mabeta P., Sosibo N., Tshikhudo R. and Pepper M.S. Nanoparticle-based chemotherapy inhibits tumour- associated angiogenesis in a murine vascular tumour model. International Conference on Drug Discovery and Therapy, Dubai, UAE. February 1st - 4th, 2010.
164. Skeen M., Eksteen C. and Pepper M.S. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. Neuroscience Day, University of Pretoria, South Africa. 26 May 2010.
165. Potgieter M., Pretorius R. and Pepper M.S. The effect of antioxidant supplementation in dysferlin- deficient muscular dystrophy mice. Neuroscience Day, University of Pretoria, South Africa. 26 May 2010.
166. Skeen M., Eksteen C. and Pepper M.S. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. 49th International Spinal Cord Society (ISCoS) Meeting, New Delhi, India. 29-31 October 2010.
167. Alessandrini M., Dodgen T., Asfaha S. and Pepper M. Genetic and phenotypic variation of CYP450 enzymes in African populations. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010.
168. Dodgen T.M., Drögemöller B.I., Wright G.E.B, Warnich L., Cromarty A.D and Pepper M.S. Pharmacogenetics of CYP2C19 for personalizing medication in the South African population. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010.
169. Potgieter M., Pretorius E., Beukes M. and Pepper M. The effect of antioxidant supplementation in dysferlin-deficient muscular dystrophy mice. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010.
170. Skeen M.C., Eksteen C. and Pepper M. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010.
- 99 - 171. Myburgh R., Salmon P., Sorce S., Hirschel B., Pepper M.S. and Krause K.-H. HIV gene therapy by CCR5 knockdown using multiple short hairpin RNAs. 4ème journée de l'innovation, Hôpitaux universitaires de Genève. Geneva (Switzerland), 13 October 2010.
172. Alessandrini M., Asfaha S.M., Dodgen T.M., Warnich L. and Pepper M.S. Genotypic and Phenotypic Variability Related to CYP450 Metabolism in African Populations. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.
173. Dodgen T.M., Drögemöller B.I., Wright G.E.B, Warnich L., Fickl H., Steffens F.E., Cromarty A.D and Pepper M.S. Evaluation of CYP2C19 genotype and phenotype in a representative sample of the South African population. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.
174. Dodgen T.M., Labuschagne C.D.J, van Schalkwyk A., Fickl H., Cromarty A.D. and Pepper M.S. Evaluation of CYP2D6 genotype and phenotype in a representative sample of the South African population. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.
175. Dodgen T.M., Eloff A., Mataboge C., Roos J.L., van Staden C.W., Pepper M.S. Risperidone-associated adverse drug reactions and Cytochrome P450 2D6 polymorphisms: a pilot study Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.
176. Logan M.G., van der Merwe M-T., Myburg R., Eloff A., Rheeder P. and Pepper M.S. Melanocortin 4 receptor (MC4R) polymorphisms in a South African study group. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.
177. Barmania F., Potgieter M. and Pepper MS. Analysis of CCR5 expressing CD4 cells and mutations in the CCR5 gene in African and Caucasian South African population groups. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011.
178. Potgieter M., van Vollenstee F., Kallmeyer K., Dessels C., Jackson C. and Pepper M.S. Human mesenchymal stem cells: isolation, characterization and differentiation. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011.
179. Rangaka I., Alessandrini M. and Pepper M.S. Economic feasibility for establishing a public cord blood stem cell bank in South Africa. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011.
180. Meissner-Roloff M., Young W., Mellet J., Rangaka I. and Pepper M.S. Establishing a public human umbilical cord blood stem cell bank – a pilot study. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011.
181. Mabeta P. and Pepper M.S. Suppression of Akt activity and bcl-2 expression is associated with the inhibition of hemangiomagenesis. International Symposium on Anti-Angiogenic Therapy. San Diego, CA, February 2, 2012.
182. van Vollenstee F., Jackson C., Hoffmann D., Kallmeyer K., Potgieter M., Durant C. and Pepper M.S. The optimization of GFP positive lentiviral vectors and assessment of the characteristics of transduced mesenchymal stem cells. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
183. Rangaka I., Alessandrini M. and Pepper, M.S. Operational model and cost implications for establishing a public cord blood stem cell bank in South Africa. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
- 100 - 184. Van Rensburg J., Alessandrini M. and Pepper M. Exploring the accuracy of mutation frequency data for monogenic disorders: the use of metachromatic leukodystrophy as a case and point. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
185. Meissner-Roloff M. and Pepper M.S. Establishing a public umbilical cord blood stem cell bank for South Africa: Social feasibility. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
186. Alessandrini M., Klose K. and Pepper M.S. University entrepreneurship in South Africa: results from a national survey of technology transfer practices. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
187. Potgieter M., Durandt C., De Villiers D. and Pepper M.S. The effect of light activation on mesenchymal stem cell phenotype. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
188. Skeen M., Eksteen C. and Pepper M.S. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. 52nd Annual Meeting of the International Spinal Cord Society, Istanbul, 28-30 October, 2013.
189. De Bruin K., Potgieter M., De Villiers P. and Pepper M.S. A theoretical probabilistic approach to mesenchymal stem cell proliferation modelling. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
190. De Villiers D., Potgieter M., Durandt C. and Pepper M.S. The effect of hydrogen peroxide on the adipogenic differentiation potential of mesenchymal stem cells. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
191. Stewart C., van Rensburg J., Alessandrini M., Masekela R., Green R. and Pepper M.S. Minding the gap – addressing the lack of South African cystic fibrosis patient data. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
192. Mellet J., Gray C. and Pepper M.S. HLA typing: conventional techniques vs. next generation sequencing.
193. Durandt C., van Vollenstee F., Kallmeyer K., de Villiers D., Honing C., Potgieter M. and Pepper M.S. Novel flow cytometric approach for the detection of adipocyte sub-populations during adipogenesis. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
194. Potgieter M., Alessandrini M. and Pepper M.S. Mesenchymal stem cells: the clinical trial landscape. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
195. Van Vollenstee F., Gaggia L., Hoffman D., Kallmeyer K., Potgieter M., Coetzee P., Vermeulen M. and Pepper M.S. Evaluation of the PROCLEIX ULTRIO Plus assay for the detection of HIV-1 in umbilical cord- and adipose tissue derived mesenchymal stem cells. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
196. Kallmeyer K., van Vollenstee F., Potgieter M. and Pepper M.S. Isolation and characterization of mesenchymal stem cells from human tissues. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
197. Alessandrini. M., Beltchev. E., Pool. R. and Pepper M.S. Diagnosis of acute myeloid leukaemia in south Africa by means of microarray technology. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
198. Alessandrini M. and Pepper M.S. Defining the need for pharmacogenetic profiling in Africa: A perspective on cytochrome P450. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013.
- 101 - 199. Alessandrini M., Beltchev E., Pool R. and Pepper M.S. AMLprofiler: Evaluation of a novel diagnostic for acute myeloid leukaemia in the South African setting. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013.
200. Alessandrini M., Beltchev E., Pool R. and Pepper M.S. AMLprofiler: Evaluation of a novel diagnostic microarray for acute myeloid leukaemia in the South African setting. Young Researchers Forum, University of the Witwatersrand, South Africa, 5 October 2013.10.19.
201. Mellet, J., Gray C.M. and Pepper M.S. HLA typing: conventional techniques versus next generation sequencing. Young Researchers Forum, University of the Witwatersrand, South Africa, 5 October 2013.
202. Mellet, J., Gray C.M. and Pepper M.S. HLA typing: conventional techniques versus next generation sequencing. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013.
203. Stewart. C., van Rensburg. J., Alessandrini. M., Masekela. R., Green. R. and Pepper M.S. The requirement for a population-specific diagnostic tool for CF in South Africa. Young Researchers Forum, University of the Witwatersrand, South Africa, 5 October 2013.
204. Stewart. C., van Rensburg. J., Alessandrini. M., Masekela. R., Green. R. and Pepper M.S. The requirement for a population-specific diagnostic tool for CF in South Africa. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013.
205. Alessandrini M. and Pepper M.S. Priority Pharmacogenetics for the African continent: a view on cytochrome P450. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
206. Van Rensburg J., Alessandrini M. and Pepper M.S. Determining the accuracy of mutation diversity measurements in metachromatic leukodystrophy. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
207. Stewart C., Van Rensburg J., Alessandrini M., Masekela R., Green R. and Pepper M.S. The requirement for a population-specific diagnostic tool for CF in South Africa. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
208. Mellet J., Gray C.M. and Pepper M.S. HLA typing: Conventional techniques versus next generation sequencing. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
209. Alessandrini M., Beltchev E., Pool R. and Pepper MS. Implementation of the AMLprofiler microarray for the diagnosis and prognosis of acute myeloid leukaemia in South Africa. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
210. Pepper MS. The human genome. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus, Kingston , Jamaica, 22 November 2013.
211. Pepper MS. Stem cells – current reality and future promise. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus, Kingston , Jamaica, 22 November 2013.
212. Durandt C., van Vollenstee F.A., Dessels C., Kallmeyer K., Potgieter M., de Villiers D., Honing C., and Pepper M.S. Novel flow cytometric approach for the detection of adipocyte sub-populations during adipogenesis. XXIX Congress of the International Society for Advancement of Cytometry. Ft Lauderdale, Florida, USA. 17-21 May 2014.
213. Alessandrini M and Pepper M.S. Establishing a public umbilical cord blood stem cell bank for South Africa: an enquiry into public acceptability. 4th Ethics, Human Rights and Medical Law conference at the Africa Health Congress. Gallagher Convention Center. 29 May 2014
- 102 - 214. Van Wyk J., Pepper M.S., van der Walt I. and Honing C. Shepherding data on the way to long term stewardship: Research Data Management at the University of Pretoria: a case study. 12th Southern African Online Information Meeting (SAOIM), June 2014.
215. Kallmeyer K., Van Vollenstee F.A., Durandt C., Potgieter M. and Pepper M.S. Isolation and characterization of mesenchymal stem cells from human tissues.17th World Congress of Basic & Clinical Pharmacology, Cape Town, 13-18 July 2014.
216. Dessels C., Alessandrini M. and Pepper M.S. Umbilical Cord Blood Banks: A Perspective. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
217. Jackson C.S., Durandt C., Praloran V., Brunet de la Grange P., and Pepper M.S. Targeting The ARNT Complex With DMOG And Stemregenin 1 Improves the Expansion of Primitive Hematopoietic Cells. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
218. Stewart C., van Rensburg J., Alessandrini M., Masekela R., Green R., Zampoli M., Kerbelker T. and Pepper M.S. Towards A South African Cystic Fibrosis Patient Registry. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
219. Kiper I., Dessels C., Pepper M.S. and Durandt C. Comparasion Of Nile Red And Bodipy 493/503 Staining On Quantification Of Lipid Content Of Adipocytes Using Fluorescence Microscopy. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
220. Van Rensburg, J., Alessandrini, M. and Pepper, M.S. Rarefaction and Metachromatic Leukodystrophy: A Unifying Factor in Medical Genetics and Ecological Disciplines. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
221. Theron A.E., Lafanechère L., Pepper M.S., Prudent R., Viallet J., Jackson C., Durandt C. and Joubert A.M. Novel Sulphamiolated Analogues Exhibit Promising In Vitro and In Ovo Anti-Cancer Properties. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
222. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
223. De Bruin K.J.F., Dessels C., De Villiers J.P. and Pepper M.S. Estimation of Cell Counts and Confluency of Adherent Adipose-Derived Stem Cells Using Unstained Phase-Contrast Micrographs. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
224. Kallmeyer K., van Vollenstee F.A., Durandt C., Potgieter M. and Pepper M.S. Differences in Basic Biological Characteristics Exist Between Adipose- and Wharton’s Jelly-Derived Mesenchymal Stromal Cells. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
225. Alessandrini M., Potgieter M. and Pepper M.S. Mesenchymal Stem Cell Therapy: Overview of Clinical Indications. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
226. Kappala S.S., Alessandrini M., Beltchev E., Matlahko T., Pool R. and Pepper M.S. Evaluation of AMLprofiler Compared to the Standard Diagnostic Procedures in Patients with Acute Myeloid Leukemia. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
227. Dessels C., Alessandrini M. and Pepper M.S. Umbilical Cord Blood Banks: A Perspective. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
228. Jackson C.S., Durandt C., Praloran V., Brunet de la Grange P., and Pepper M.S. Targeting The ARNT Complex With DMOG And Stemregenin 1 Improves the Expansion of Primitive Hematopoietic Cells. - 103 - International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technolgy, Pretoria. 27-31 August 2014.
229. Durandt C., van Vollenstee A., Dessels C., Kallmeyer K., Kiper I., de Villiers D., Honing C., Potgieter M., Hoffman D. and Pepper M.S. A multi-colour flow cytometry approach to quantify various stages during adipocyte differentiation: Comparison between Nile Red & Bodipy 493/503. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
230. De Villiers D., Potgieter M., Durandt C. and Pepper M.S. The effect of induced oxidative stress and antioxidant supplementation on the adipogenic differentiation potential of adipose-derived mesenchymal stem cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
231. Van Vollenstee F.A., Jackson C., Hoffmann D., Kallmeyer K., Potgieter M., Durandt C. and Pepper M.S. Immunophenotypical characterisation and differentiation capacity of transduced human adipose derived mesenchymal stromal cells by optimized GFP positive lentiviral vectors International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
232. Van Vollenstee F.A., Gaggia L., Hoffmann D., Kallmeyer K., Potgieter M., Coetzee P.F., Vermeulen M. and Pepper M.S. Establishment of a useful molecular platform to for the detection of HIV-1 in umbilical cord- and adipose tissue-derived mesenchymal stem cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
233. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
234. Mellet J. and Pepper M.S. Constituting a public umbilical cord blood bank in South Africa: Demographics, linguistics, and HLA diversity. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
235. De Bruin K.J.F., Dessels C., De Villiers J.P. and Pepper M.S. Estimation of Cell Counts and Confluency of Adherent Adipose-Derived Stem Cells Using Unstained Phase-Contrast Micrographs. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
236. Kallmeyer K. , van Vollenstee F.A., Durandt C., Potgieter M. and Pepper M.S. Differences in Basic Biological Characteristics Exist Between Adipose- and Wharton’s Jelly-Derived Mesenchymal Stromal Cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
237. McGillewie L., Jackson C., Pepper M.S. and Durandt C. Does multi-colour flow cytometry allow for the identification of primitive cord blood-derived hematopoietic stem cells, using only surface marker staining? International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
238. Alessandrini M., Potgieter M. and Pepper M.S. Clinical indications for mesenchymal stem cell therapy. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
239. Alessandrini M. and Pepper M.S. Establishment of a sustainable public cord blood stem cell bank for South Africa. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
- 104 - 240. Alessandrini M., Krause K-H., Speck R.F., Salman P., Myburg R. and Pepper M.S. Clinical Translation of an HIV Gene Therapy. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland.
241. Myburgh R., Pepper M.S., Speck R.F., Krause K-H. and Salmon P. Improved knockdown of target genes via miRNA. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland.
242. Myburgh R., Pepper M.S., Salman P., Krause K-H. and Speck R.F. Gene engineering an HIV resistant immune system. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland.
243. Speck R., Hirschel B., Krause K-H., Salmon P., Myburgh R. and Pepper M. TGT: cure HIV through engineering of an HIV-resistant immune system. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland.
244. Mabeta P., Davis P.F. and Pepper M.S. Vascular specific growth factors in angiogenesis: signaling pathways and therapeutic targeting. 42nd Annual Conference of the Physiology Society of Southern Africa, Durban, South Africa, 14-17 Sept 2014.
245. Kappala S., Alessandrini M., Beltchev E., Matlahko T., Pool R. and Pepper M.S. AMLprofiler: A novel diagnostic tool for patients with acute myeloid leukemia in South Africa. UNIPATH 2014 (Unifying Pathology and Laboratory Medicine in the Era of P4 Medicine), CSIR International Convention Centre, Pretoria, South Africa, 19-21 Sept 2014.
246. Durandt C. and Pepper M.S. Adipose Tissue As An Immunological Active Organ. UNIPATH. CSIR, Pretoria. 19-21 September 2014.
247. Alessandrini M., Kappala S.S., Beltchev E., Matlahko T., Pool R. and Pepper M.S. Diagnostic nd Prognostic Value of AMLprofiler in the South African Context. UNIPATH. CSIR, Pretoria. 19-21 September 2014.
248. Kappala S.S., Alessandrini M., Beltchev E., Matlahko T., Pool R. and Pepper M.S. Evaluation of AMLprofiler Compared to the Standard Diagnostic Procedures in Patients with Acute Myeloid Leukemia. UNIPATH. CSIR, Pretoria. 19-21 September 2014.
249. Jackson C.S. and Pepper M.S. Analyzing techniques to improve the transduction of HSCs. South African Genetics Society Congress. 23-26 September 2014.
250. Alessandrini M., Kappala S., Matlahko T., Beltchev E., Pool R. and Pepper M.S. AMLprofiler. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.
251. Colic A., Alessandrini M. and Pepper M.S. Pharmacogenetics of CYP2B6, CYP2A6, and UGT2B7 in HIV treatment in African populations. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.
252. Jackson C.S., Durandt C, de la Grange P.B., Praloran V. and Pepper M.S. Improving the expansion and transduction of primitive hematopoietic stem cells. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.
253. Stewart C., van Rensburg J., Zampoli M., Kerbelker T., Masekela R., Green R. and Pepper M.S. In the blood – Identifying cystic fibrosis mutations in South African patients. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.
254. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014. - 105 -
255. Theron A.E., Lafanechère L., Pepper M.S., Prudent R., Viallet J., Jackson C., Durandt C, and Joubert A.M. Novel in silico-designed anti-cancer compounds: from in vitro exploration to potential clinical considerations. 4th World Congress on Cancer Science & Therapy, October 2014.
256. Alessandrini M. and Pepper M.S. Establishment of a public cord blood stem cell bank for South Africa. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
257. Dessels C., Alessandrini M. and Pepper M.S. The treatment landscape of umbilical cord blood banks. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
258. Jackson C.S., Durandt C., Brunet de la Grange P., Praloran V. and Pepper M.S. Targeting the HIF complex with DMOG and stemregenin 1 mediates the improved expansion of primitive hematopoietic cells. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
259. Jackson C.S. and Pepper M.S. Improving lentivirus transduction of primitive HSCs. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
260. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
261. Mellet J. and Pepper M.S. Constituting a public umbilical cord blood bank in South Africa: Demographics, linguistics, and HLA diversity. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
262. Alessandrini M. and Pepper M.S. Establishment of a public cord blood stem cell bank for South Africa Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
263. Dessels C., Alessandrini M. and Pepper M.S. 21 Years of Umbilical Cord Blood Banks: The Treatment Landscape (poster presentation). The Pathology Research and Development Congress 2015, Emperors Palace, Kempton Park, SA. 14-16 April 2015.
264. Jackson C.S. and Pepper M.S. Improving Lentivirus Transduction of Primitive Hematopoietic Stem Cells (oral presentation). The Pathology Research and Development Congress 2015, Emperors Palace, Kempton Park, SA. 14-16 April 2015.
265. Stewart C., van Rensburg J., Masekela R., Green R., Kerbelker T., Zampoli M. and Pepper M.S. The Molecular Genetic Epidemiology of Cystic Fibrosis in South Africa (oral presentation). The Pathology Research and Development Congress 2015, Emperors Palace, Kempton Park, SA. 14-16 April 2015.
266. De Villiers D., Potgieter M., Durandt C. and Pepper MS. The Effect of Artificial Hypoxia on Adipogenic Differentiation in Adipose-Derived Stromal Cells (poster presentation). The Pathology Research and Development Congress 2015, Emperors Palace, Kempton Park, SA. 14-16 April 2015.
267. Van Vollenstee F.A., Jackson C., Hoffmann D., Kallmeyer K. and Pepper M.S. Characterization of lentiviral transduced GFP-positive human adipose derived stromal cells; a potential model for tracking stem cells in pre-clinical studies (poster). The Pathology Research and Development Congress 2015, Emperors Palace, Kempton Park, SA. 14-16 April 2015.
268. Van Rensburg J., Alessandrini M., Robertson M. and Pepper M.S. Rarefaction & Metachromatic Leukodystrophy: A Unifying Factor in Medical Genetics & Ecological Disciplines (poster presentation). The Pathology Research and Development Congress 2015, Emperors Palace, Kempton Park, SA. 14-16 April 2015. - 106 -
269. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort (poster). The Pathology Research and Development Congress 2015, Emperors Palace, Kempton Park, SA. 14-16 April 2015.
270. Alessandrini M. and Pepper M.S. Clinical Translation of a HIV Gene Therapy (oral presentation). The Pathology Research and Development Congress 2015, Emperors Palace, Kempton Park, SA. 14-16 April 2015.
271. Kappala S.S., Alessandrini M., Matlhako T., Beltchev E., Pool R. and Pepper M.S. Evaluation of AMLprofiler for Acute Myeloid Leukemia Patients in South Africa (oral presentation). The Pathology Research and Development Congress 2015, Emperors Palace, Kempton Park, SA. 14-16 April 2015.
272. Myburgh R., Ivic S., Pepper M.S., Gers-Huber G., Li D., Audigé A., Rochat M., Jaquet V., Regenass S., Salmon P., Krause K.-H. and Speck R. F. Lentivector Knock-Down of CCR5 in Hematopoietic Stem Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice. American Society of Gene & Cell Therapy 18th Annual Meeting. New Orleans, Louisiana, USA. 13-16 May 2015.
273. Pepper M.S., Myburgh R., Jackson C.S., Alessandrini M., Salmon P., Krause K.-H. and Speck R.F. Rendering the Immune System Resistant to HIV. BioInnovation Day 2015. Lausanne, Switzerland. 23 June 2015.
274. Kallmeyer K., Modarressi A., Lévigne D., Baquié M., Pittet-Cuénod B. and Pepper, M.S. In Vivo Cell Tracking of Adipose-Derived Mesenchymal Stromal Cells. PhD Retreat, University of Geneva, 31 July 2015.
275. Stewart C., van Rensburg J., Oduaran O., Masekela R., Green R., Zampoli M. and Pepper M.S. Finger on the pulse – the utility of establishing a national CF registry (oral). 16th Biennial Congress of the Southern African Society for Human Genetics, KleinKaap Boutique Hotel, Centurion, Pretoria. 16-19 August 2015.
276. Van Rensburg J., Alessandrini M., Robertson M. and Pepper M.S. Cystic Fibrosis and Rarefaction: Unification Through Diversity (oral). 16th Biennial Congress of the Southern African Society for Human Genetics, KleinKaap Boutique Hotel, Centurion, Pretoria. 16-19 August 2015.
277. Ambele M., Dessels C. and Pepper M.S. Genome-Wide Analysis of Gene Expression during Adipogenesis in Human Adipose-Derived Mesenchymal Stromal Cells (ASCs). 16th Biennial Congress of the Southern African Society for Human Genetics, KleinKaap Boutique Hotel, Centurion, Pretoria. 16-19 August 2015.
278. Kappala S.S., Alessandrini M., Matlhako T., Beltchev E., Pool R. and Pepper M.S. AMLprofiler: Evaluation of a novel diagnostic microarray for Acute Myeloid Leukemia patients in South Africa (poster). 16th Biennial Congress of the Southern African Society for Human Genetics, KleinKaap Boutique Hotel, Centurion, Pretoria. 16-19 August 2015.
279. Dessels C., Alessandrini M. and Pepper M.S. 21 Years of Umbilical Cord Blood Banks: The Treatment Landscape. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
280. Dessels C., Durandt C. and Pepper M.S. Pooled Human Platelet Lysate: An Alternative to FBS. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
281. Jackson C.S. and Pepper M.S. Improving Lentivirus Transduction of Primitive Hematopoietic Stem Cells. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
282. Stewart C., van Rensburg J., Oduaran O., Masekela R., Green R., Zampoli M., Kerbelker T., Westwood, T. and Pepper M.S. Cystic Fibrosis: An African Public Health Roadmap. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
- 107 - 283. Durandt C., Mellet J. and Pepper M.S. Isolation of umbilical cord blood-derived hematopoietic stem cells: A comparison between FACS and MACS. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
284. Durandt C., van Vollenstee F.A., Dessels C. , Kallmeyer K., Potgieter M., de Villiers D. , Murdock C. and Pepper M.S. Multi-colour flow cytometric approach for the detection of adipocyte sub-populations during adipogenesis. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
285. De Villiers D., Potgieter M., Durandt C. and Pepper MS. The Effect of Artificial Hypoxia on Adipogenic Differentiation in Adipose-Derived Stromal Cells. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
286. De Villiers D., Potgieter M., Durandt C. and Pepper MS. The Effect of Coenzyme Q10 on Adipogenic Differentiation in Adipose-Derived Stromal Cells. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
287. Van Vollenstee F.A. and Pepper M.S. Preliminary Expansion Prediction Model for Adipose Derived Stromal/Stem Cells. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
288. Van Rensburg J., Alessandrini M., Robertson M. and Pepper M.S. Cystic Fibrosis and Rarefaction: Unification Through Diversity. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
289. Viljoen J.W., De Villiers J.P. and Pepper M.S. Modelling the Etiology and Symptoms of Cystic Fibrosis using Bayesian Networks. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
290. Theron A.E., Jackson C., Durandt C., Nolte E.M., Repsold L., Marais S., Prudent R., Lafanechere L., Pepper M.S. and Joubert A.M. Ex vivo Effects of Novel Anti-Cancer Agents on the Human Haematopoietic System. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
291. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
292. De Bruin K.J.F., De Villiers J.P. and Pepper M.S. In Silico Insights into In Vitro Contact-Inhibited Cell Proliferation. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
293. Kallmeyer K., Modarressi A., Lévigne D., Baquié M., Pittet-Cuénod B. and Pepper M.S. Adipose-Derived Mesenchymal Stromal Cell Homing: In Vivo Cell Tracking. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
294. Alessandrini M. and Pepper M.S. Clinical Translation of a HIV Gene Therapy. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
295. Alessandrini M., De Bruin K., Potgieter M. and Pepper M.S. Mesenchymal Stem Cell Therapy in Clinical Trials: Update 2015. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
296. Ambele M.A., Dessels C. and Pepper M.S. In Silico Prediction of Transcriptional Factors Constituting the Gene Regulatory Network that Drives Adipogenesis in Adipose-Derived Stromal Cells. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
297. Tshabalala M., Mellet J. and Pepper M.S. Lack of Human Leukocyte Antigen (HLA) Diversity Data in South Africa: Implications for Transplantation & Disease Association Studies. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
298. Kappala S.S., Alessandrini M., Matlhako T., Beltchev E., Pool R. and Pepper M.S. Evaluation of the AMLprofiler: A Novel Diagnostic Tool for Acute Myeloid Leukemia Patients in South Africa. Faculty Day, Health Sciences, University of Pretoria, 18-19 August 2015.
- 108 - 299. Dessels, C., Alessandrini, M. and Pepper, M.S. 21 years of umbilical cord blood banks: the treatment landscape. International Conference, African Pride, Irene Country Hotel, Irene, South Africa. 17-18 September 2015.
300. Alessandrini M. and Pepper M.S. Establishment of a public cord blood stem cell bank for South Africa. SATIBA International Conference, African Pride, Irene Country Hotel, Irene, South Africa. 17-18 September 2015.
301. Mellet J., Rangaka I., Alessandrini M. and Pepper M.S. Public Cord Blood Bank in South Africa. SATIBA International Conference, African Pride, Irene Country Hotel, Irene, South Africa. 17-18 September 2015.
302. Tshabalala M. and Pepper M.S. Lack of Human Leukocyte Antigen (HLA) Diversity Data in South Africa: Implications for Transplantation & Disease Association Studies. SATIBA International Conference, African Pride, Irene Country Hotel, Irene, South Africa. 17-18 September 2015.
303. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA typing techniques versus next generation sequencing in a South African cohort. SATIBA International Conference, African Pride, Irene Country Hotel, Irene, South Africa. 17-18 September 2015.
304. Gouveia C., Huyser C. and Pepper M.S. A comparative analysis of techniques required for somatic cell nuclear transfer using the mouse as a model (poster). SASREG 2015 National Congress, "New Debates in Endoscopy and Infertility," Investec Bank Global Head Office, Johannesburg, South Africa. 30 October -1 November 2015.
305. Stewart C. and Pepper M. A genomics-driven public health solution to the cystic fibrosis problem in Africa. Genomic Research Institute Symposium 2015. University of Pretoria, 29 October 2015.
306. Van Rensburg J., Alessandrini M., Robertson M. and Pepper M. Cystic fibrosis and rarefaction: Unification through diversity. Genomic Research Institute Symposium 2015. University of Pretoria, 29 October 2015.
307. Alessandrini M. and Pepper M. Initiation of an HIV gene therapy clinical trial in South Africa. Genomic Research Institute Symposium 2015. University of Pretoria, 29 October 2015.
308. Ambele M., Dessels C. and Pepper M. Potential biomarkers characterizing adipocyte differentiation revealed from genome-wide gene expression studies of human adipogenesis. Genomic Research Institute Symposium 2015. University of Pretoria, 29 October 2015.
309. Tshabalala M., Mellet J. and Pepper M.S. Towards understanding human leukocyte antigen (HLA) diversity in southern African populations. Genomic Research Institute Symposium 2015. University of Pretoria, 29 October 2015.
310. Pepper M.S. and Joubert F. The Southern African Human Genome Programme. Genomic Research Institute Symposium 2015. University of Pretoria, 29 October 2015.
311. Stewart C., van Rensburg J., Masekela R., Zampoli M., Kerbelker T., Green R.J. and Pepper M.S. A Molecular Investigation of Cystic Fibrosis in South Africa. ECFS Diagnostic Network Working Group Meeting. London, UK. 11-13 February 2016.
312. Alessandrini M., Krause K-H., Speck R.F., Salmon P., Myburgh R. and Pepper M.S. Clinical Translation of an HIV Gene Therapy. Infectious Diseases Day, Faculty of Health Sciences, University of Pretoria. 12 February 2016.
313. Pepper M.S. and Stewart C. Monogenic disorders (CF in particular) and the importance of exome sequencing in identifying novel variants in our genetically diverse population. P5 Africa Congress, Vineyard Hotel, Cape Town, SA. 23-24 March 2016.
- 109 - 314. Stewart C., van Rensburg J., Masekela R., Zampoli M., Kerbelker T., Green R. and Pepper M.S. Genomics & Social Justice – Diagnosing Cystic Fibrosis in South Africa 13th International Congress of Human Genetics. Kyoto, Japan. 3-7 April 2016.
315. Čolić A., Alessandrini M. and Pepper M.S. Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7: Relevance to HIV treatment in African populations. Pharmacogenetics and Precision Medicine Conference, University of Cape Town, South Africa. 4-9 April 2016.
316. Alessandrini M., Chaudhry M., Rademan J., Dodgen T.M., Steffens F.E., Van Zyl D. and Pepper M.S. CYP2D6 variation in the context of amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: A pilot investigation. Pharmacogenetics and Precision Medicine Conference, University of Cape Town, South Africa. 4-9 April 2016.
317. Choudhury A., Hazelhurst S., Mulder N., Joubert F., Aron A., Gamieldien J., Botha G., Meintjes A., Chimusa E., Jalali M., Sengupta D., Bardien S., Christoffels A., Mpahlele J., Soodyal H., Ramesar R., Rees J., Theron K., Venter P., Warnich L., Pepper M.S. and Ramsay M. Southern African Human Genome Programme: Deep whole genome sequencing provides insights into the genetic architecture of South Africans. 9th Congress of the African Society of Human Genetics, Dakar, Senegal. 14-17 May 2016.
318. Stewart C., Oduaran O., van Rensburg J., Masekela R., Zampoli M., Kerbelker T., Green R.J. and Pepper M.S. Struggling to Breathe: Challenges and solutions to diagnosing cystic fibrosis in Africa. 9th Congress of the African Society of Human Genetics, Dakar, Senegal. 14-17 May 2016.
319. Alessandrini M., Kappala S., Matlahko T., Beltchev E., Pool R. and Pepper M.S. Utility of a microarray diagnostic for AML in the South African setting. 9th Congress of the African Society of Human Genetics, Dakar, Senegal. 14-17 May 2016.
320. Ambele M.A., Dessels C. and Pepper M.S. Transcriptome analysis of human adipogenesis reveals novel patterns ofin gene expression. 9th Congress of the African Society of Human Genetics, Dakar, Senegal. 14-17 May 2016.
321. Rademan J., Dodgen T.M., Alessandrini M., Steffens F.E., Chaudhry M., Van Zyl D. and Pepper M.S. CYP2D6 variation in the context of amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: A pilot investigation. 9th Congress of the African Society of Human Genetics, Dakar, Senegal. 14-17 May 2016.
322. Tshabalala M., Mellet J., Christoffels A. and Pepper M.S. Towards understanding HLA diversity in southern Africans: implications for transplantation and disease association studies. 9th Congress of the African Society of Human Genetics, Dakar, Senegal. 14-17 May 2016.
323. Oduaran O.H., C. Stewart C., van Rensburg J., Masekela R., Zampoli M., Kerbelker T., Green R.J. and Pepper M.S. Cystic Fibrosis: A Molecular Investigation. 9th Congress of the African Society of Human Genetics, Dakar, Senegal. 14-17 May 2016.
324. Durandt C., van Vollenstee F.A., Dessels C., Kallmeyer K., de Villiers D., Murdoch C., Potgieter M. and Pepper M.S. Novel Flow Cytometric Approach For The Detection Of Adipocyte Sub-Populations During Adipogenesis. 31st Congres of the International Society for Advancement of Cytometry. Seattle, Washington, USA. 11-15 June 2016.
325. Mellet J., Durandt C. and Pepper M.S. Culture of HSCs in vitro according to GMP-standards. 31st Congres of the International Society for Advancement of Cytometry. Seattle, Washington, USA. 11-15 June 2016.
326. Brown A., Ballo R., Pepper M. and Kidson S. Generation of dermal papillae with hair follicle inductive potential from mesenchymal stem cells. Dermatology Congress 2016. Cape Town, South Africa. 11-14 August 2016.
- 110 - 327. Dessels C., Durandt C. and Pepper M.S. Expansion of Human Adipose-Derived Stromal Cells: Human Alternatives To Foetal Bovine Serum. Faculty Research Day, Health Sciences, University of Pretoria. 23- 24 August 2016.
328. Jackson C.S. and Pepper M.S. Improving The Engraftment Potential Of Lentivirus Transduced Hematopoietic Stem Cells. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
329. Gouveia C., Huyser C. and Pepper M.S. Experimental Setup of Somatic Cell Nuclear Transfer: Procedural Optimization. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
330. Stewart C., van Rensburg J., Oduaran O., Masekela R., Green R.J., Zampoli M. and Pepper M.S. Cystic Fibrosis in Africa: A Problem of Diagnosis. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
331. Durandt C., van Vollenstee F.A., Dessels C., Kallmeyer K., de Villiers D., Murdoch C., Potgieter, M. and Pepper M.S. Novel Flow Cytometric Approach For The Detection Of Adipocyte Sub-Populations During Adipogenesis. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
332. Wolmarans E., Durandt C., Dessels C., Ambele, M. and Pepper, M.S. The Search for the Side Population in Adipose-derived Stromal Cells. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
333. George G.E., Pepper M.S., Van Dyk G., Pool R., Rossouw T. and Durandt C. Haematological Manifestations in HIV-1 Infected, Treatment Naive Participants From Eersterust Community Health Clinic. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
334. Mellet J., Durandt C. and Pepper M.S. Culture of Hematopoietic Stem Cells in Vitro According to GMP- Standards. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
335. Kallmeyer K., Lévigne D., Modarressi A., Pittet-Cuénod B. and Pepper M.S. In vivo tracking of adipose- derived mesenchymal stromal cells (ASCs) during physiological wound repair. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
336. Adam L.T., Pepper M.S. and Durandt C. Do Adipose-Derived Stromal Cells Possess Endocytic Function? Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
337. Alessandrini M., Kappala S., Matlahko T., Beltchev E., Pool R. and Pepper M.S. Application of the AMLprofilerTM Microarray in South Africa for the Diagnosis of Acute Myeloid Leukaemia. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
338. Chaudhry M., Alessandrini M., Rademan J., Dodgen T.M., Steffens F.E., Van Zyl D.G., Gaedigk A. and Pepper M.S. Variation In The CYP2D6 Gene May Predict Amitriptyline Efficacy In Patients With Diabetic Peripheral Neuropathy. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
339. Tshabalala M., Mellet J., Christoffels A. and Pepper M.S. Towards understanding HLA diversity in southern Africans: implications for transplantation and disease association studies. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
340. Oduaran O.H., Stewart C., van Rensburg J., Masekela R., Zampoli M., Kerbelker T., Green R.J. and Pepper M.S. Cystic Fibrosis: A Molecular Investigation. Faculty Research Day, Health Sciences, University of Pretoria. 23-24 August 2016.
341. Oloyo A.K. and Pepper M.S. Contrasting views on the role of mesenchymal stromal/stem cells in tumor progression: A systematic review. 7th International Congress of the African Association of Physiological Sciences. Lagos, Nigeria, 5-8 September 2016. - 111 -
342. Ambele M. and Pepper M.S. Novel transcription regulatory pathways potentially involved in adipocyte differentiation. 3rd Annual GRI Symposium, University of Pretoria, Pretoria, South Africa, 18 November 2016.
343. Dessels C., Ambele M. and Pepper M.S. Transcriptomic profile of adipose-derived stromal cells expanded in pooled human platelet lysate or foetal bovine serum. 3rd Annual GRI Symposium, University of Pretoria, Pretoria, South Africa, 18 November 2016.
344. Stewart C., van Rensburg J., Zampoli M., Kerbelker T., Masekela R., Jeevarathnum A., Green R., White D., Macaulay S., Baird C., and Pepper M.S. Balancing the scales: Diagnosing cystic fibrosis in South African patients. 3rd Annual GRI Symposium, University of Pretoria, Pretoria, South Africa.18 November 2016.
345. Ambele M.A., Van Zyl A.W., Pepper M.S and van Heerden W.F.P. Mapping the genetic landscape of oral cancer in South African patients. Wits Cancer Research Symposium. Johannesburg, South Africa. 09 February 2017.
346. Kallmeyer, K., Lévigne, D., Pepper, M.S., Pittet-Cuénod, B., Modarressi, A. The fate of systemic and local administered adipose-derived mesenchymal stromal cells to modulate wound repair. 28th Annual EURAPS Meeting, Pisa, Italy, 25-27 May 2017.
347. Chirehwa, M., Naidoo, A., Ramsuran, V., McIlleron, H., Naidoo, K., Ende-Zuma, N., Singh, R., Ngapu, S., Pepper M., Chauhdry, M., Padayatchi, N. and Denti, P. A semi-physiological model for moxifloxacin pharmacokinetics accounting for the effect of co-administered drugs and genetic polymorphisms. Population Approach Group Europe (PAGE) Conference, Budapest, Hungary, 6-7 June 2017.
348. Wolmarans E., Durandt C. and Pepper M.S. The search for the side population in human adipose-derived stromal cells. 2nd International Conference on Tissue Engineering and Regenerative Medicine (ICTERM).Vanderbijlpark, South Africa. 26-30 July 2017.
349. Kallmeyer K., Modarressi A., Pittet-Cuénod B. and Pepper, M.S. The fate of systemic and local administered adipose-derived mesenchymal stromal cells to modulate wound repair. 2nd International Conference on Tissue Engineering and Regenerative Medicine (ICTERM).Vanderbijlpark, South Africa. 26-30 July 2017.
350. Ambele M.A., Dessels C. and Pepper M.S. Comprehensive transcriptomic profile of adipogenic differentiation in human adipose derived stromal cells. 2nd International Conference on Tissue Engineering and Regenerative Medicine (ICTERM).Vanderbijlpark, South Africa. 26-30 July 2017.
351. Stewart C. and Pepper M.S. Transforming the Way Cystic Fibrosis Is Diagnosed. 17th Biennial Congress of the Southern African Society for Human Genetics. Durban, South Africa. 13-16 August 2017.
352. Durandt, C., George, G.E., van Dyk, G., Pool, R., Rossouw, T. and Pepper, M.S. Haemotological manifestations in HIV-1 infected treatment naïve participants from Eersterust Community Health Clinic. Faculty Research Day, Health Sciences, University of Pretoria, 22-23 August 2017.
353. Durandt, C., Dessels, C. and Pepper M.S. Do in vitro expansion and cryopreservation have an effect on the adipogeneic potential of adipose-derived stromal cells? Faculty Research Day, Health Sciences, University of Pretoria. 22-23 August 2017.
354. Wolmarans, E., Durandt, C., Dessels, C., Ambele, M. and Pepper, M.S. The search for the side population in adipose-derived stromal cells. Faculty Research Day, Health Sciences, University of Pretoria. 22-23 August 2017.
- 112 - 355. Mellet, J., Wolmarans, E., Durandt, C., Alessandrini, M. and Pepper, M.S. Hematopoietic stem and progenitor cell transcriptomic heterogeneity: analysis at the single-cell level. Faculty Research Day, Health Sciences, University of Pretoria. 22-23 August 2017.
356. Kallmeyer K., Lévigne, D., Modarressi A., Pittet-Cuénod B. and Pepper, M.S. The fate of systemic and local administered ASCs to modulate wound repair. Faculty Research Day, Health Sciences, University of Pretoria. 22-23 August 2017.
357. Ambele, M. and Pepper, M.S. Transcription factors in adipogenesis. Faculty Research Day, Health Sciences, University of Pretoria. 22-23 August 2017.
358. Tshabalala, M., Ingram, C., Schlaphoff, T., Borrill,V., Christoffels, A. and Pepper, M.S. Human Leukocyte Antigen (HLA) -A, -B, -C, -DRB1, and -DQB1 allele and haplotype frequencies of donors in the South African Bone Marrow Registry (SABMR). Faculty Research Day, Health Sciences, University of Pretoria. 22-23 August 2017.
359. Grobbelaar, S., Durandt, C., Pepper, M.S., Verwey, M., Becker, P., Gerdener, T., McDonald, A., Brittain, D. and Mercier, A.E. Value of total nucleated- and CD34+ cell counts as predictors of engraftment in multiple myeloma patients: A pilot study. Faculty Research Day, Health Sciences, University of Pretoria. 22-23 August 2017.
360. Mabeta P. and Pepper M.S. New insights into the pathophysiology of infantile haemangiomas: implications for treatment. Dermatology Society of South Africa Annual Congress 2017. Pretoria, South Africa. 24-27 August 2017.
361. Mercier, A.E., Lafanechère, L., Prudent, R., Pepper, M. and Joubert, A.M. Local neoplastic invasion and metastasis formation are diminished due to aberrant actin stress fibre formation and extracellular milieu modifications in response to novel microtubule disruptors. 45th Conference of the Physiology Society of Southern Africa, University of Pretoria, Pretoria. 27-31 August 2017.
362. Mercier, A.E., Pepper, M.S. Jackson, C. Durandt, C. Nolte, E.M., Repsold, L., Marais, S., Prudent, R. Lafanechere, L. and Joubert, A.M. Ex vivo effects of novel anti-cancer agents on the human haematopoietic system. 45th Conference of the Physiology Society of Southern Africa, University of Pretoria, Pretoria. 27-31 August 2017.
363. Grobbelaar, S., Mercier, A.E., Pepper, M.S., Verwey, M., Becker, P., Gerdener, T., McDonald, A., Thompson, D., and Durandt, C. . Value of total nucleated- and CD34+ cell counts as predictors of engraftment in multiple myeloma patients: A pilot study. 45th Conference of the Physiology Society of Southern Africa, University of Pretoria, Pretoria. 27-31 August 2017.
364. Kallmeyer, K., Lévigne, D., Pepper, M.S., Pittet-Cuénod, B., Modarressi, A. The fate of systemic and local administered adipose-derived mesenchymal stromal cells to modulate wound repair. 53rd Swiss Society of Plastic, Reconstructive and Aesthetic Surgery (SSCPRE-SGPRAC) Congress. St Moritz, Switzerland, 1-2 September 2017.
365. Durandt, C., Dessels, C. and Pepper M.S. Do in vitro expansion and cryopreservation have an effect on the adipogeneic potential of adipose-derived stromal cells? SATIBA International Conference 2017. Leriba Hotel & Spa, Clubview, Centurion, 5-6 October 2017.
366. Wolmarans, E., Durandt, C., Dessels, C., Ambele, M. and Pepper, M.S. The search for the side population in adipose-derived stromal cells. SATIBA International Conference 2017. Leriba Hotel & Spa, Clubview, Centurion, 5-6 October 2017.
367. Mellet, J., Wolmarans, E., Durandt, C., Alessandrini, M. and Pepper, M.S. Hematopoietic stem and progenitor cell transcriptomic heterogeneity: analysis at the single-cell level. SATIBA International Conference 2017. Leriba Hotel & Spa, Clubview, Centurion, 5-6 October 2017.
- 113 - 368. Tshabalala, M., Ingram, C., Schlaphoff, T., Borrill,V., Christoffels, A. and Pepper, M.S. Human Leukocyte Antigen (HLA) -A, -B, -C, -DRB1, and -DQB1 allele and haplotype frequencies of donors in the South African Bone Marrow Registry (SABMR). SATIBA International Conference 2017. Leriba Hotel & Spa, Clubview, Centurion, 5-6 October 2017.
369. Durandt, C., van Vollenstee, F.A., Dessels, C., Kallmeyer, K., Potgieter, M., de Villiers, D., da Silva, C., Honing, C. and Pepper, M.S. Identifying Different Stages Of Adipocyte Differentiation Using The Fatty Acid Translocase, CD36. SAMRC Flagship Stem Cell and Biobanking Conference. Innovation Hub, Pretoria. 26 & 27 October 2017.
370. Durandt, C., Meissner-Roloff, M., Mellet, J. and Pepper M.S. Flow Cytometric Enumeration Of Total Nucleated Cells Using Novel Membrane Permeable DNA Probes. SAMRC Flagship Stem Cell and Biobanking Conference. Innovation Hub, Pretoria. 26 & 27 October 2017.
371. Ambele, M.A., Dessels, C., Durandt, C. and Pepper, M.S. Comprehensive transcriptome analysis of human adipogenesis in vitro. SAMRC Flagship Stem Cell and Biobanking Conference. Innovation Hub, Pretoria. 26 & 27 October 2017.
372. Pepper, M.S. Cell-based therapy: the legislative environment in South Africa. SAMRC Flagship Stem Cell and Biobanking Conference. Innovation Hub, Pretoria. 26 & 27 October 2017.
373. Tshabalala, M., Pepper, M.S. and Christoffels, A. HLA diversity in South Africa: Insights from individuals typed at varying resolution by NHLS. SAMRC Flagship Stem Cell and Biobanking Conference. Innovation Hub, Pretoria. 26 & 27 October 2017.
374. Grobbelaar, S., Durandt, C., Pepper, M.S., Verwey, M., Becker, P., Gerdener, T., McDonald, A., Brittain, D. and Mercier, A.E. Value of total nucleated- and CD34+ cell counts as predictors of engraftment in multiple myeloma patients: A pilot study. SAMRC Flagship Stem Cell and Biobanking Conference. Innovation Hub, Pretoria. 26 & 27 October 2017.
375. Pepper, M.S. Research Ethics of Human Genetics/Genomics. GRI Symposium, University of Pretoria, 10 November 2017.
376. Grobbelaar, S., Durandt, C., Pepper, M.S., Verwey, M., Becker, P., Gerdener, T., McDonald, A., Brittain, D. and Mercier, A.E. Value of total nucleated- and CD34+ cell counts as predictors of engraftment in multiple myeloma patients: A pilot study. 14th South African Stem Cell Transplantation Society Conference. Protea Hotel Balalaika, Sandton, Johannesburg. 10-11 November 2017.
377. Kallmeyer, K., Lévigne, D., Pepper, M.S., Pittet-Cuénod, B., Modarressi, A. The fate of systemic and local administered adipose-derived mesenchymal stromal cells to modulate wound repair. International Federation for Adipose Therapeutics and Science, Miami, Florida. 30 November – 2 December 2017.
378. Leisewitz, A.L., Pepper, M.S., Ambele, A.A. and Hefer, C.A. A transcriptomic approach to evaluating disease pathogenesis in Babesia rossi infection in dogs. Molecular and Clinical Aspects of Human Babesiosis, Yale University, West Haven, CT. 12-13 April 2018.
379. Kallmeyer, K., Andrè-Lévigne, D., Pepper, M.S., Pittet-Cuénod, B. and Modarressi, A. The Effect of Adipose-Derived Mesenchymal Stromal Cells Administered Locally for Wound Repair. 29th EURAPS Annual Meeting 2018, Madrid, Spain. 17-19 May 2018.
380. Stoffels, M., Kramer, A.H., Houseman, P.S., Kadye, R., Pepper, M.S. and Prinsloo, E. Does STAT3 serine 727 phosphorylation contribute to lipid accumulation during adipogenesis: Preliminary evidence. South African Societies of Biochemistry and Molecular Biology (SASBMB) Conference 2018, Potchefstroom, 8- 11 June 2018.
381. Mercier, A.E., Lafanechère, L., Pepper, M.S. and Joubert, A.M. Intra- and extracellular signalling pathways activated in cancer cells by microtubule disruptors structurally modified to bind preferentially to - 114 - carbonic anhydrase IX. 5th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets, Chania, Crete, Greece. 8-13 June 2018.
382. Kallmeyer, K., Andrè-Lévigne, D., Pepper, M.S., Pittet-Cuénod, B. and Modarressi, A. The Effect of Adipose-Derived Mesenchymal Stromal Cells Administered Locally for Wound Repair. PhD Day, Faculty of Medicine, Geneva University, 27 June 2018.
383. Du Plessis, N.M., Muller, C.J.B., Avenant, T., Goga, A.E. and Pepper, M.S. Predictive probability models for targeted birth HIV PCR testing. 10th International Workshop on HIV paediatrics, Amsterdam, The Netherlands. 20-21 July 2018.
384. Herd C., Mellet J., Durandt C. and Pepper, M.S. Selecting HSPC populations for analysis of haematopoietic potential by CFU-assay after HIV-1 exposure. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
385. Da Silva, C., Durandt,C., Kallmeyer, K., Dessels, C., Anderson R., Ambele M. and Pepper, M.S. The role of Pref-1 in the adipogenic differentiation of mesemchymal stromal/stem cells in vitro. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
386. Wickham, C.H., Durandt, C. and Pepper, M.S. Factors influencing susceptibility of CD4+ T lymphocytes to HIV-1-C and the host cell response to virus exposure. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
387. Durandt, C., Dessels, C. and Pepper, M.S. Effect of expansion and cryopreservation on the in vitro adipogenic differentiation potential of adipose-derived stromal cells. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
388. Wolmarans, E., Mellet, J., Durandt, C. and Pepper, M.S. The capture and reverse-transcription of single- cell adipose-derived stromal cells using Fluidigm’s C1 technology. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
389. Wolmarans, E., Durandt, C. and Pepper, M.S. ABC transporters and “side population” in human adipose- derived stromal cells. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
390. Van Rensburg J. Outcomes following therapeutic hyperthermia in SA and global clinical trial HIE patients. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
391. Mellet J., Durandt, C. and Pepper, M.S. Cytokines for the ex vivo expansion of hematopoietic stem and progenitor cells. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
392. Kallmeyer, K., Andrè-Lévigne, D., Pepper, M.S., Pittet-Cuénod, B. and Modarressi, A. The Effect of Adipose-Derived Mesenchymal Stromal Cells Administered Locally for Wound Repair. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
393. Adam, L., Ambele, M., Durandt, D. and Pepper, M.S. Effects of reactive oxygen species scavengers on adipogenesis. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
394. Nel, M., Mercier, A.E., Pepper, M.S., Grobbelaar, S., Becker, P., Gerdener, T., McDonald, A., Brittain, D., Thompson, D. and Durandt, C. Clinical parameters that affect the rate of engraftment in multiple myeloma patients: a pilot study. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
395. Ambele, M.A., Pepper, M.S., van Heerden, M.B. and van Heerden, W.F.P. Molecular profiling of hpv negative oral squamous cell carcinoma with differential p16 expression patterns. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
396. Tshabalala, M., Christoffels, A. and Pepper, M.S. Human Leukocyte Antigen diversity in South African populations. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018. - 115 -
397. Du Plessis, N.M., Muller, C.J.B., Avenant, T., Goga, A.E. and Pepper, M.S. Predictive probability models for targeted birth HIV PCR testing. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
398. Grobbelaar, S., Mercier, A.E., Pepper, M.S., Nel, M., Becker, P., Gerdener, T., McDonald, A., Brittain, D., Thompson, D. and Durandt, C. Total nucleated cell counts are predictive of engraftment outcomes in multiple myeloma patients: a pilot study. Faculty Research Day, Health Sciences, University of Pretoria, 21-22 August 2018.
399. Kallmeyer, K., Andrè-Lévigne, D., Pepper, M.S., Pittet-Cuénod, B. and Modarressi, A. The Effect of Adipose-Derived Mesenchymal Stromal Cells Administered Locally for Wound Repair. 4th PhD Retreat of the Faculty of Medicine, Geneva. 3-5th October 2018.
400. Kallmeyer, K., Andrè-Lévigne, D., Pepper, M.S., Pittet-Cuénod, B. and Modarressi, A. The Effect of Adipose-Derived Mesenchymal Stromal Cells Administered Locally for Wound Repair. 16th International Federation of Adipose Therapeutics and Science (IFATS) Annual Meeting, 2018, Las Vegas, America, USA, 13-16 December 2018.
401. Gouveia C., Huyser C. and Pepper M.S. Optimization of techniques required for somatic cell nuclear transfer using a mouse model: Results. Reproductive Medicine Conference hosted by the University of Pretoria’s Reproductive & Endocrine Unit, Dept. Obstetrics & Gynaecology, Ekurhuleni International Convention Centre, Kempton Park, Johannesburg. 25 November 2018.