Michael Sean PEPPER, Curriculum Vitae
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Professional address Room 5-64, Level 5, Pathology Building 5 Bophelo Road (Cnr. Steve Biko and Dr. Savage Streets) Prinshof Campus University of Pretoria Gezina 0002 Pretoria South Africa Tel: +27 (0)12 319 2179 (Secretary) Tel: +27 (0)12 319 2190 (Direct) Fax: +27 (0)12 319 2946 E-mail: [email protected]
EDUCATION
Privat Docent (Habilitation) University of Geneva, Faculty of Medicine, 1997
M.D. University of Geneva, Faculty of Medicine, 1992
Ph.D. University of Geneva, Faculty of Science, 1990
M.B.Ch.B. University of Cape Town Medical School, 1982
REGISTRATION
Health Professionals Council of South Africa (HPCSA) registration no.: MP 0261858 Board of Health Funders practice no.: 0140000207756 The South African Medical Association. Member no.: 30227
PROFESSIONAL APPOINTMENTS
Current
December 2011-present Professor, Department of Immunology, Faculty of Health Sciences, University of Pretoria
December 2011-present Director, Institute for Cellular and Molecular Medicine, University of Pretoria
January 2006-present Professeur Associé, Department of Human Genetics and Development, Faculty of Medicine, University of Geneva
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Previous
August 2008-November 2011 Professor, Unit for Advanced Studies, University of Pretoria
January 2005-November 2011 Extraordinary Professor, Department of Immunology, Faculty of Health Sciences, University of Pretoria
January 2007-July 2009 Scientific Director, Netcells Cryogenics (Pty) Ltd
January 2005-July 2008 Managing Director, Netcare Institute of Cellular and Molecular Medicine (Pty) Ltd, Unitas Hospital, Lyttelton, Pretoria
July-December 2004 Professor: Department of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand
January-June 2004 Associate Professor (part-time): Department of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand
June 2003-June 2004 Associate Professor: Department of Morphology, Faculty of Medicine, University of Geneva
Oct 1993-May 2003 Maître d'enseignement et de recherche (Assistant Professor, with tenure): Department of Morphology, Faculty of Medicine, University of Geneva
Jan 1991-Sept 1993 Maître-assistant: Department of Morphology, Faculty of Medicine, University of Geneva
April 1986-Dec 1990 Assistant and Ph.D. student: Department of Morphology, Faculty of Medicine, University of Geneva
1984-March 1986 Department of Clinical Science and Immunology, Faculty of Medicine, University of Cape Town 1984: Post-intern research scholarship; 1985/6: Registrar
1983 Intern: Groote Schuur Hospital, Cape Town
AWARDS AND OTHER RECOGNITION
Exceptional Academic Achiever Award, University of Pretoria, 2015-2017.
Selected for inclusion in the book “Blazing a Biotechnology Trail – Celebrating Biotechnology Excellence in South Africa”. Produced by Public Understanding of Biotechnology (NRF/SAASTA), 2014
South African MRC Extramural Unit Award: Stem Cell Research and Therapy. 2015-2020.
South African MRC University Flagship Award: Stem Cell Research and Therapy, 2014-2017.
Appointed to the Academy of Science of South Africa, 2013.
- 3 - Finalist, NSTF-BHP Billiton Awards 2013/2014 in the category: Communication for outreach and creating awareness of Science, Engineering, Technology and Innovation.
Finalist, NSTF-BHP Billiton Awards 2012/2013 in the category: Science Communication for Public Awareness over the last 5 years. Sponsored by: The South African Agency for Science and Technology Advancement (SAASTA-NRF).
P. Mabeta and M.S. Pepper: Best overall publication, non-clinical. Faculty of Health Sciences, University of Pretoria, 2009. P. Mabeta and M.S. Pepper: Best overall publication, non-clinical. Faculty of Health Sciences, University of Pretoria, 2011(2012).
“Prix Denber-Pinard” for Privat Docent thesis. University of Geneva, 1997.
Walter J. Johnson Annual Award for post-doctoral research in cell biology. Molecular biology and biochemistry of endothelial cell proteases and their inhibitors. Awarded by Academic Press/Experimental Cell Research, 1994.
“Prix de la Faculté de Médecine” for M.D. thesis in basic medical sciences. University of Geneva, 1992.
South African Medical Research Council Post-Intern Research Scholarship. University of Cape Town, 1984.
SOCIETIES/ASSOCIATIONS
South African Tissue Bank Association (Co-founder; 2012-present) Human Genome Organization (2010-present) South African Genetics Society (2010-present) Southern African Society of Human Genetics (2009-present) World Marrow Donor Association – individual member (2009-present) South African Medico-Legal Society (2009-present) South African Stem Cell Transplantation Society (2008-present) BioSA (Biotechnology SMME Association of South Africa) (Co-founder; 2007-present; President: 2008) Licensing Executives Society (2008-2011) South African Society for Obesity and Metabolism (2006-2008; Member of the EXCOM) European Vascular Biology Association. (1993-2004; Treasurer: 1996-2004)
COMMITTEES / WORKING GROUPS / SCIENTIFIC BOARD
National Bio-economy Strategy (Department of Science and Technology) Health Innovation Strategy implementation panel, 2014-present Core Planning Group, 2010-2011 Biobank South Africa Working Group – 2014-present (Co-chair with Prof Ames Dhai) Member of the Advisory Committee of the African Center for Gene Technologies – 2010-present Co-responsible (with Prof Michele Ramsay) for the Southern African Human Genome Programme – 2009- present Core Committee, Revision of Chapter 8 of the National Health Act and Human Tissue Regulations (National Department of Health) – 2009-present National Public Umbilical Cord Blood Stem Cell Bank Feasibility Study (National Department of Health and South African National Blood Service) – 2009-present National Advisory Council on Innovation – 2012-2014 (Project leader: Bioeconomy policies and strategies) National Biotechnology Advisory Committee to the Minister of Science and Technology (2006-2012) Chairperson: May-September 2012; Deputy Chair: July 2010-April 2012; Acting Chairperson: October 2009-June 2010
- 4 - Regional Gauteng Province Biotech Awards, Adjudication Committee – 2009
University of Pretoria Faculty of Health Sciences Research Committee of the School of Medicine. 2013-present. Research Forum Committee. Chairperson. 2012-present Research Committee of the Faculty of Health Sciences. 2012-present Comprehensive Physical Rehabilitation Research Centre. Advisory Board. 2008 Faculty Research Plan. Committee member. 2006
University of Geneva Medical School Scientific board, Institut des sciences du mouvement et de la médecine du sport. 2003 Committee for the evaluation of PhD students salaries. 2003 MD-PhD program. Committee member. 1995-2003 Committee for problem-based teaching program, 2nd and 3rd year medical students. 1999-2002 Committee for the evaluation of teaching. 1996-1997; 2002 Working group: DNA microarrays. 1999 Working group: integration of basic and clinical sciences. 1997
Network Healthcare Holdings (Netcare) Research Committee. 2005-2008 Bursary Committee. 2007
BIOTECH/PHARMACEUTICAL CONSULTANT ACTIVITY
Consultant Merck KGaA, Darmstadt, Germany. 2003-2005. Ampath, Pretoria, South Africa. 2004 Modex Therapeutics, Lausanne, Switzerland. 2000-2002. Transgène SA, Strasbourg, France. 1999-2000.
Ad hoc consultant activity Defined Health, Milburn (NJ, USA) Merck KGaA, Darmstadt (Germany) Novo Nordisk A/S, Maalov (Denmark) Serono International SA, Geneva (Switzerland) LifeScan Inc., Johannesburg (South Africa)
TRAINING COURSES ATTENDED
Southern African Human Genome Programme: Understanding and Characterizing Southern African Genomes. Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg. 28-31 July 2014
IP Rights from Publicly Funded Research and Developmnent, Center for IP Law, University of Pretoria and Adams and Adams (Pretoria, South Africa). 30 September 2011.
Empowering genomics in southern Africa workshop – Application to infectious diseases.University of Limpopo (Polokwane, South Africa). 30 May – 1 June 2011.
Essential IP Management Short Course. DNAbiotec (Pty) Ltd. The Innovation Hub (Pretoria, South Africa). 12- 13 November 2009.
Introductory Licensing Workshop. Licensing Executives Society. Lynnwood Conference Center (Pretoria, South Africa). 26 November 2008. - 5 -
Good clinical practice. Wits Health Consortium. (Johannesburg, South Africa). 22 May 2007.
Maximizing Performance. (Johannesburg, South Africa). 2007
EXCO Finance for Non-financila Managers. Netcare Education. (Pretoria, South Africa). 2006. Course organizer: Mr. Graeme Jay.
Swiss 2D PAGE Training Course, Geneva University Hospital (Geneva, Switzerland), 25-29 September 2000. Course organizer: Dr. J.-C. Sanchez.
Cours Romand de Formation à l‟Expérimentation Animale, Centre Hospitalier Universitaire Vaudois (Lausanne, Switzerland), 1-5 May 2000. Course organizers: Dr. I. Bolon, Dr. E. Rouiller, Dr. M. Gyger, Dr. T. Pedrazzini.
Immunocytochemistry for Light Microscopy, Royal Postgraduate Medical School, Hammersmith Hospital (London, U.K.), 14-18 January 1985. Course organizer: Dr. J.M. Polak.
Elective in Orthopaedic Surgery, Toronto Western Hospital (Toronto, Canada), 7 November - 18 December 1981. Host: Dr. R.W. Jackson. Sponsorship: the Journal of Bone and Joint Surgery.
LECTURE SERIES / WORKSHOPS / SYMPOSIUMS ORGANISED
Southern African Human Genome Programme (SAHGP) Ethical, Legal and Social Issues (ELSI) workshop Co-organizer, Prof Himla Soodyall Casa Toscana, Pretoria 19 November 2014
MRC University Flagship Award: Stem cell research and therapy University of Pretoria 01 September 2014
Plastic, reconstructive and aesthetic surgery: at the interface between basic and clinical sciences Intervarsity symposium: University of Pretoria, University of the Witwatersrand, MEDUNSA, University of Geneva, Switzerland University of Pretoria 23 June 2014
Swiss-South African Joint Research Program (SSAJRP), Inter-group meeting Biel/Bienne, Switzerland 18 & 19 June 2014
BASAN/UP Inaugural Clean Room Forum University of Pretoria 10 October 2013
Genomics research on indigenous populations: exploring the concept of genomic sovereignty with the San community of southern Africa Kalahari Lodge, Kimberley 10-12 September, 2013
“The Science of Our Times” lecture series Atterbury Theatre, Pretoria 06 August 2013: Stem cells: the hype and the hope 29 October 2013: The human genome 04 February 2014: Sex determination and gender identity - 6 -
South African Tissue Bank Association (SATiBA) Cascades Guesthouse, Brooklyn, Pretoria: 29 November 2012 SATiBA launch - Blu Raddison, Sandton: 4 May 2012
Research Forum Committee meetings, Faculty of Health Sciences, University of Pretoria, South Africa Postgraduate student forum: 09 November 2012 28 August 2012 Postgraduate supervisor‟s forum: 15 November 2012 27 August 2012
SAASTA/PUB Critical Thinker‟s Forum The Southern African Human Genome Programme, Baxter Theatre, Cape Town, South Africa. 24 November, 2011 Stem Cells, St George‟s Hotel & Convention Center, Doornkloof, South Africa. 07 November, 2012
Institute for Cellular and Molecular Medicine Day The Innovation Hub, Pretoria, South Africa 02 November, 2012
Certificate in Bioentrepreneurship (Continuing Education at the University of Pretoria) 21-25 October, 2013 – Pretoria, South Africa 08-12 October, 2012 – Cape Town, South Africa 17-21 September, 2012 – Pretoria, South Africa 16-20 July, 2012 – Durban, South Africa 11-15 June, 2012 – Grahamstown, South Africa 19-23 September, 2011 – Cape Town, South Africa 22-26 August 2011 – Pretoria, South Africa 18-22 October, 2010 – Pretoria, South Africa 28 September-3 October, 2009 – Pretoria, South Africa
Medical Malpractice Litigation Seminar Institute for Cellular and Molecular Medicine, University of Pretoria, South Africa. 28 September, 2012 25 August, 2012
Legal aspects relating to the applications of biotechnology College of Law, Unisa, Pretoria, South Africa Co-organizer with Prof. Melodie Slabbert 21 August 2012
Neuroscience Day University of Pretoria, Pretoria, South Africa 10 May 2012 19 May 2011 26 May 2010
Emerging Stem Cell Technologies. Dissecting the complex scientific, ethical and legal landscape Institute for Cellular and Molecular Medicine, University of Pretoria Cricklewood Manor, Pretoria, South Africa 29 September, 2011
Engineering an HIV-resistant Immune System CSIR Conference Center, Pretoria, South Africa - 7 - Travel grants from the Swiss-South African Joint Research Program for Profs. Karl-Heinz Krause and Roberto Speck - CHF 3 000 (~R 20 000) 10-11 February, 2011
Southern African Human Genome Program Co-organizer with Prof. Michele Ramsay Irene Lodge, Irene, South Africa 27-28 January, 2011
Stem Cell Transplantation Indaba Co-organizer with Drs. Campbell Macfarlane and Carola Nielser Waterfront, Cape Town, South Africa 02-03 August, 2010
Technology Transfer in South Africa Organized in collaboration with the World Bank Institute and SARIMA Cape Town, South Africa 27 November, 2009
The Human Tissue Regulatory Environment The Innovatiopn Hub, Pretoria 27 May, 2009
GoGlobal: Finland. BioSA-COFISA workshops on global opportunities for the South African biotech sector BioSa visit to Finland: 13-15 February 2008 Definitive workshops in SA: 31 March – 03 April 2008 Preliminary workshops in SA: 21-27 February 2008
Bioethics Forum on Stem Cell Banking. Pretoria, South Africa Co-organizer with Adv. Donrich Jordaan 15 June 2007
7th Annual European Conference of Scientists and Plastic surgeons. Geneva, Switzerland Local Scientific Committee 19-20 September, 2003
New Therapeutic Targets in Vascular Biology. Geneva, Switzerland Co-organizer 06-09 February, 2003
International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies Geneva, Switzerland. Organizing committee/Faculty member 8th meeting, 31 January – 02 February, 2002 7th meeting, 25-27 January, 2001 6th meeting, 27-29 January, 2000 5th meeting, 31 January – 02 February, 1999
Co-organizer of the "Journée d'interaction des groupes de recherche des Facultés de médecine de Lausanne et Genève, Changins, Switzerland 4th meeting, 19 October 2000 3rd meeting, 07 October, 1999 2nd meeting, 08 October, 1998 1st meeting, 16 October, 1997
XIth International Vascular Biology Meeting. Geneva, Switzerland Scientific Committee 06-10 September, 2000 - 8 -
Molecular and Cellular Biology of Plasminogen Activation. Les Diablerets, Switzerland Local organizing Committee 04-09 September 1999
Symposium entitled "Positive and negative regulation of angiogenesis: from cell biology to the clinic" at the 29ème Assemblée annuelle de l'Union des Sociétés Suisses de Biologie Expérimentale. Geneva, Switzerland 21 March, 1997
Workshop entitled "Angiogenesis: mechanistic insights and disease" at the 30th Annual Meeting of the European Society for Clinical Investigation. Interlaken, Switzerland Co-organiser with E. Battegay, Basel, Switzerland 25 April, 1996
EXPERT WITNESS
Nel and Nel vs. Steyn, Burger, Springs Private Hospital Group (Pty) Ltd, Zambakides and Stepien. South Gauteng High Court, Johannesburg (Republic of South Africa). Case no. 2004/15546 and 06/17316. 19-23 August, 2010.
CLINICAL WORK
CLINICAL TRAINING
Jan – Dec 1983 Intern: Groote Schuur Hospital, Cape Town General Medicine (4 months), General Surgery (4 months), Emergency Medicine (2 months), Orthopaedic Surgery (2 months)
Jan 1985 – March 1986 Registrar: Groote Schuur Hospital, Cape Town Department of Clinical Science and Immunology
CLINICAL ACTIVITY
Consultant, Gender Reassignment Cinic, Dept Obstetrics and Gynaecology, Steve Biko Academic Hospital. 2013-present.
Permanent consultant, Multidisciplinary consultation for hemangiomas and vascular malformations. Geneva University Hospital. 1994-2004.
Ad hoc consultant, Departments/Divisions of Pediatrics, Dermatology, Surgery (Pediatric, Neuro, Plastic), Radiology and Oncology, Geneva University Hospital. 1990-2004.
REVIEWER ACTIVITIES
RESEARCH GRANT COMMITTEES
Medical Research Council (South Africa)
- 9 - Research Grants Committee of the Medical Research Council. 2012-2014
National Research Foundation (South Africa)
Human Capacity and Infrastructure Development (HICD) Panel Meeting: Thuthuka applications for 2014 funding and Thuthuka and IRDP annual progress reports. 18 October 2013 Capacity and strategic platforms grants – Health Sciences panel: Thuthuka applications for 2013 funding and Thuthuka and IRDP annual progress reports. 15 November 2012 Capacity and Strategic Platforms Grants (CSPG) Panel: Sabbatical Programme 2013 Funding. 20 March 2013
EDITORIAL BOARDS & EDITORSHIPS
Current Lymphatic Research and Biology. Editorial Board. 2002-present Current Angiogenesis. 2011-present The Journal of Medical Law and Ethics. International Editorial Board. 2012-present Applied and Translational Genomics. 2012-present
Previous Associate Editor/Editorial Board. Arteriosclerosis, Thrombosis & Vascular Biology. 1995-2007 Editorial Advisory Board. The Angiogenesis Journal. 1997-2007 Current Cardiology Reviews. 2005-2009 The Open General and Internal Medicine Journal. 2007-2010
Editor of Ampath Molecular and Metabolic Medicine Update newsletter 2005: 3 editions 2006: 6 editions 2007: 6 editions 2008: 6 editions 2009: 4 editions
GUEST EDITOR
Applied and Translational Genomics. Special edition on “Pharmacogenomics and Personalized Medicine”. 2012-2013.
ONSITE REVIEWER ACTIVITIES / PANELS
CSIR Biosciences Review Panel, CSIR, Pretoria. 9-11 July, 2014. Panel member.
International Centre for Genetic Engineering and Biotechnology (ICGEB) site visit for the 5 year review of Prof. Iqbal Parker. Cape Town, South Africa. August 14 2012. Panel member.
MRC-NHLS-Wits Human Genomic Diversity and Disease Research Unit (Prof. Himla Soodyall). Johannesburg, South Africa. 27 September 2010. Panel member.
MRC-UCT Human Genetics Research Unit (Prof. Raj Ramesar). Cape Town, South Africa. 22 September 2009. Panel member.
AD HOC REVIEWING
Articles submitted to journals
- 10 - AIDS Patient Care and STDs, American Journal of Pathology, American Journal of Physiology, Angiogenesis Journal, Applied and Translational Genomics, Arteriosclerosis Thrombosis and Vascular Biology, Biochemical and Biophysical Research Communications, Blood, British Journal of Pharmacology, Cancer Cell, Cancer Journal, Cancer Research, Cell, Cell and Tissue Research, Circulation, Circulation Research, Comparative and International Law Journal of Southern Africa, Current Cardiology Reviews, Current Medicinal Chemistry, Dermatology, Developing World Bioethics, Development, Developmental Biology, EMBO Journal, European Journal of Clinical Investigation, Experimental Cell Research, Experimental Hematology, Expert Opinion On Biological Therapy, FAESB Journal, FEBS Letters, Frontiers in Medicine Gastroenterology, Gene Therapy, International Journal of Cancer, Journal of Cell Biology, Journal of Cell Science, Journal of Cellular Physiology, Journal of Clinical Investigation, Journal of Clinical Pathology, Journal of Histochemistry and Cytochemistry, Journal of Investigative Dermatology, Journal of the National Cancer Institute, Journal of Neurosurgery, Laboratory Investigation, Lung Cancer, Microcirculation, Microvascular Research, Molecular and Cellular Biology, Molecular Biology of the Cell, Nature, Nature Medicine, Oncogene, Opthalmologie, PLoS ONE, Proceedings of The National Academy of Sciences USA, Public Health Nutrition, Science, South African Journal of Psychiatry, Stem Cell Reviews and Reports, The Lancet, Thrombosis and Haemostasis, Tydskrif vir Hedendaagse Romeins-Hollandse Reg (Journal of Contemporary South African Roman-Dutch Law).
Research funding applications
Association for International Cancer Research, Biotechnology and Biological Sciences Research Council (UK), CANSA, Christie Hospital NHS Trust, Dutch Cancer Society, European Commission, Fondation Carlos et Elise de Reuter, French Ministry of Research and Education, German-Israel Foundation for Scientific Research & Development, Josef Steiner Stiftung, March of Dimes, Katholieke Universiteit Leuven, Medical Research Council (South Africa), National Science Foundation (USA), NATO Collaborative Research Grants, National Research Foundation (South Africa), Natural Sciences and Engineering Research Council of Canada, Netherlands Organization for Scientific Research, Research Council of the University of Leuven, Swiss Cancer League, Swiss National Science Foundation, The Israel Science Foundation, The Wellcome Trust, United States-Israel Binational Science Foundation, Volkswagen Stiftung.
Candidates for academic positions and prizes
Deutsche Forschungsgemeinschaft; Imperial Cancer Research Fund; Max-Planck-Gesellschaft; South African Research Chair Initiative; Swiss National Science Foundation; University of Bern; University of Cape Town; University of Fribourg; University of California (Los Angeles); University of the Witwatersrand; The Wellcome Trust.
Other
Business plans for several entities National Research Foundation (South Africa) – scientist rating.
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TEACHING
UNDERGRADUATE
Faculty of Health Sciences, University of Pretoria
Angiogenesis and lymphangiogenesis; 2nd year medical students - 1 hour (2007, 2009-present) Cell-based therapy; 2nd year medical students - 1 hour (2006-present) Pharmacogenetics; 5th year medical students - 1 hour (2009, 2011-present) Bioentrepreneurship; 2nd year BSc students studying Medical Sciences or Physiology - 1 hour (2010) Pharmacogenetics; 2nd year medical students - 1 hour (2005)
University of Geneva Medical School
Problem-based learning curriculum (1995-2004, 2006-present) Second year medical students - Tutor, “Heart and circulation” module (12-32 hours) (2001-2004, 2006-present) - Tutor, “Cell growth and ageing” module (32 hours) (1995-1999) - Tutor, integration module 1 (4 hours) (1997) - Monitor, practical histology course, “Heart and circulation” module (4 hours) (1996-2004/7) - Monitor, practical histopathology course, “Heart and circulation” module (4 hours) (1999, 2003/4/6/9/10/14) - Monitor, practical anatomical pathology course, “Heart and circulation” module (8 hours) (2003 (responsible), 2006, 2008-2013) Third year medical students - Co-responsible, “Locomotion” module (1999-2002) - Tutor, “Locomotion” module (32 hours) (1998-2003) - Lecture, integration module 2: Mécanismes de l'hypertrophie du myocarde et de l'insuffisance cardiaque (2003-2004) - Monitor, practical histology course, “Locomotion”module (4 hours) (1999-2003) - Monitor, practical histology course, “Defense & Immunity” module (4 hours) (2001-2004) - Examiner, pratical histology, module on “Locomotion” (2000-2004) - Examiner, pratical histology, module on “Defense & Immunity” (2001-2004)
Histology practical course, 1st and 2nd year medical students (1987-2004)
Histology lectures to paramedical students: blood cells, hematopoiesis, lymphoid system and blood and lymphatic vessels (4 hours) (1993-2003)
Lectures on the physiopathology of vascular diseases, 2nd year physiotherapists (4 hours) (2003)
Histology/cell biology lectures to second year medical students: Skeletal, cardiac and smooth muscle (8 hours) (1994-1997)
Faculty of Health Sciences, University of the Witwatersrand
Medical Cell Biology III (ANAT 314) - applied cell biology: 24 hours (2004)
Morphological (Gross) anatomy - MBChB II and BSc Biomedical Sciences II students (ANAT 224) (2004)
Histology lectures - MBChB II and BSc Biomedical Sciences II students (ANAT 224): bone and cartilage, lymphoid organs (2 hours) (2004)
University of Cape Town Medical School
Immunology practical course, medical students (1985/6)
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POSTGRADUATE
University of Pretoria
Early Career Academics Workshop, Department of Research Innovation and Support - Supervision. 2013
Post-graduate workshops at the Faculty of Health Sciences - Academic writing course for basic sciences: scientific writing, structure of a scientific article, journal selection. 2011, 2012
Post-graduate seminars at the Faculty of Health Sciences - Department of Medical Microbiology: The lymphatic vascular tree – the often forgotten second vascular system. 2013 - Research Forum Committee - Postgraduate student forum: Bedside to bench - defining the market in health biotechnology in South Africa. 2012 - Department of Paediatrics (Steve Biko Academic Hospital): Monogenic disorders. 2012. - Department of Obstetrics and Gynaecology (Steve Biko Academic Hospital): Legislation pertaining to cell-based therapy in South Africa: selected aspects. 2012. - Department of Immunology: Mapping the human genome: the dawning of a new era in healthcare. 2010 - Department of Paediatrics (Kalafong Hospital): Overview of stem cell principles and legislation. 2010 - Department of Paediatrics (Steve Biko Academic Hospital): Neonatal hypoxic ischaemic encephalopathy: pathophysiology and litigation. 2010 - Department of Immunology: Cell-based therapy. 2009 - Netcare Jaccaranda Hospital: Cell-based therapy in South Africa. 2007 - Department of Chemical Pathology: Pharmacogenetics: from genotype to phenotype. 2007 - Faculty Research Day: Cell-based therapy. 2006 - Department of Pharmacology: Pharmacogenetics. 2005 - Department of Pharmacology: Angiogenesis. 2005 - Department of Physiology: Hemangiomas and vascular malformations: new insights into their pathogenesis and treatment. 2004
Post-graduate seminars at the Faculty of Natural and Agricultural Sciences - Centre for Microbial Ecology & Genomics: Stem cells - the hype and the hope. 2014 - Department of Genetics: Cell-based therapy. 2008 - Department of Genetics: Pharmacogenetics: from genotype to phenotype. 2007
University of the Witwatersrand
Post-graduate seminars at the Faculty of Health Sciences - School of Anatomical Sciences: The Netcare Institute of Cellular and Molecular Medicine. 2007 - Department of Molecular Medicine and Hematology: The lymphatic vascular system: a renaissance. 2004 - School of Anatomical Sciences: Transplantation of islets of Langerhans: beyond transplantation. 2004 - School of Anatomical Sciences: Vascular malformations and hemangiomas: new insights into their pathogenesis. 2004 - School of Anatomical Sciences: The lymphatic vascular system: a renaissance. 2003
Post-graduate seminars at the Johannesburg General Hospital - Department of Medicine: Vascular malformations and hemangiomas: new insights into their pathogenesis. 2004 - Department of Chemical Pathology: Lymphangiogenesis and tumor metastasis. 2003 - Department of Endocrinology: The pathogenesis of myocardial hypertrophy. 2003
University of Geneva - 13 -
Post-graduate seminars at the Geneva University Medical Center and Hospital - Department of Genetics and Development. Genes lead the way: the promise of new technology. 2004 - Vascular biology seminar series: Vascular malformations and hemangiomas: new insights into their pathogenesis and treatment. 2004 - Department of Cellular Physiology and Metabolism: VEGF: a novel therapeutic for diabetes? 2004 - Dermatology clinic: Le système vasculaire lymphatique: une renaissance. 2004 - Division of Cardiology: Physiopathologie de l‟hypertrophie du myocarde. 2003 - Division of Oncology: Lymphangiogenèse et métastases tumorales. 2003 - Cours de microimagerie: Laser capture microdissection. 2003 - Vascular biology seminar series: Lymphatic vascular system. 2003 - Department of Surgery: Le système vasculaire lymphatique: une renaissance. 2002 - Department of Geriatrics: Le système vasculaire lymphatique: une renaissance. 2002 - Department of Neurosurgery: Angiogenèse. 2001 - Division of Oncology: Lymphangiogenèse et métastases tumorales. 2001 - Division of Medical Genetics: Angiogenèse et morphogenèse vasculaire. 2000 - Plastic and Reconstructive Surgery Unit: Physiopathologie des hémangiomes et malformations vasculaires. 2000 - Department of Medicine: Angiogenèse: où en est-on? 1999 - Department of Surgery: Angiogenèse: de la biologie cellulaire aux applications cliniques. 1999 - Division of Radio-oncology: Angiogenèse. 1998 - Division of Angiology & Hemostasis: Pathogénie des malformations vasculaires: rôle des facteurs de croissance. 1997 - Department of Medicine: Néo-angiogenèse. 1997 - Endocrinology seminar series: Régulation positive et négative de l'angiogenèse. 1996 - Pediatric clinic: Lésions vasculaires pédiatriques. 1995 - IIIe Cycle Romand en sciences biologiques. Angiogenèse et Cancer. 1994 - Division of Angiology & Hemostasis: Angiogenèse et pathologie vasculaire. 1994 - Dermatology clinic: Angiogenèse et la peau. 1994 - Department of Pharmacology: Angiogenèse in vitro. 1991 - Division of Oncology: Néo-angiogenèse. 1991
Conferences du C.M.U. University Medical Center, Geneva - Le système vasculaire lymphatique: une renaissance. 2002 - Régulation positive et negative de l'angiogenèse: de la biologie cellulaire aux applications cliniques. 1995
Histology for post-graduate students, Department of Morphology. Blood cells and hematopoiesis; blood and lymphatic vessels; cartilage and bone (6 hours). 2002-2004
Ph.D. students‟ program on molecular and cellular biology (9 hours). 2000-2004
Ph.D. students‟ course on the biology of connective tissues (4 hours). 1992-1994
University of Lausanne and Ecole Polytechnique Fédérale de Lausanne
Post-graduate seminars at the Lausanne University Hospital - Institute of Pathology: Lymphangiogenesis and tumor metastasis. 2002 - Division of Surgical Research: Manipulating angiogenesis: from basic science to the bedside. 1997 - Department of neurosurgery: Angiogenesis: a balance between positive and negative regulators. 1996
Post-graduate seminars at the Ecole Polytechnique Fédérale de Lausanne - Department of Rural Engineering: Angiogenèse et assemblage de la paroi vasculaire. 1998
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University of Cape Town
Faculty of Medicine - B.Sc. (honours) immunology course: Lymphocyte ontogeny and differentiation. 1985/6
STUDENTS
PRE-GRADUATE STUDENTS
- Thandeka Msimang (Medical student, University of Pretoria) 1 month elective, 2007 - Sophie Excoffier (Medical student, University of Geneva) 2 month training period, 2003 - Thomas Agoritsas (Medical student, University of Geneva) 2 month training period, 2001 - Patrick Myers (Medical student, University of Geneva) 2 month training period, 1999 - Gérald Hentsch (Medical student, University of Lausanne) 3 month training period, 1998
POST-GRADUATE STUDENTS
Diploma students Faculty of Science, University of Geneva - Hélène Mottaz (Department of Morphology) Oct 2002 - March 2004 - Marie Zbinden (Department of Morphology) Oct 2002 - March 2004
Honours students Faculty of Health Sciences, University of Pretoria - Carla Dessels (Department of Anatomy) 2011 - Jacobus Rademan (Department of Pharmacology) 2010 - Tyren Dodgen (Department of Pharmacology) 2007 - Eloise Fraenkel (Department of Anatomy) 2007 - Johannie du Plessis (Department of Pharmacology) 2006 - Monique du Preez (Department of Pharmacology) 2006 - Warren Hochfeld (Department of Pharmacology) 2006 Faculty of Natural and Agricultural Sciences, University of Pretoria - Antoinette Colic (Department of Biochemistry) 2014
MSc students Faculty of Health Sciences, University of Pretoria - Chantel Gouveia (Department of Immunology) 2015-present - Janis von Johannides (Department of Immunology) 2015-present - Carla Dessels (Department of Immunology) 2013-present - Danielle de Villiers (Department of Immunology) 2012-present - Jeanne van Rensberg (Department of Immunology) 2012-present - Fiona van Vollenstee (Department of Immunology) 2010-present - Juanita Mellet (Department of Immunology). Dissertation entitled: Factors determining the composition of a public cord blood stem cell bank including HLA diversity. MSc obtained in September 2013 - Karlien Kallmeyer (Department of Immunology). Dissertation entitled: Isolation and characterization of mesenchymal stem cells from human tissues. MSc obtained in September 2013 - Fatima Barmania (Department of Immunology) Dissertation entitled: Analysis of CCR5 diversity in the South African population. MSc obtained in April 2012 - Monique du Preez (Department of Immunology) Dissertation entitled: Implementation of a blood conservation program in a private hospital setting in South Africa. MSc obtained in April 2012 - Doretha Thompson (Department of Immunology) Dissertation entitled: Flow cytometric analysis of stem cells derived from umbilical cord blood. MSc obtained in April 2010 - Murray Logan (Department of Immunology). Dissertation entitled: Investigation of MC4 Receptor Polymorphisms and the Effect of Bariatric Surgery on a Selected Group of South African Obese Patients. MSc obtained in September 2009
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PhD students Faculty of Health Sciences, University of Pretoria - Nicolette du Plessis (Department of Paediatrics) 2015-present - Mqondisi Tshabalala (Department of Immunology) 2014-present - Elize Wolmarans (Department of Immunology) 2014-present - Karlien Kallmeyer (Department of Immunology) 2014-present - Juanita Mellet (Department of Immunology) 2013-present - Carlo Jackson (Department of Immunology) 2010-present - Tyren Dodgen (Department of Pharmacology). Thesis entitled: Pharmacogenetics of CYP2D6 and CYP2C19 as a pre-prescription tool for drug efficacy and toxicity in a demographically-representative sample of the South African population. PhD obtained in September 2013 - Madeleine Meissner-Roloff (Department of Immunology). Thesis entitled: The effect of HIV on the formation of colony forming units in vitro & public willingness to donate to a public cord blood bank. PhD obtained in April 2013 - Peaceful Mabeta (Department of Physiology). Thesis entitled: The effect of bleomycin, mitomycin C, and cytoskeletal-disrupting drugs on angiogenesis in vitro and haemangioma development in vivo. PhD obtained in December 2008 Faculty of Medicine, University of Geneva - Riccardo Nisato (Department of Cell Physiology and Metabolism). Thesis eititled: Role of integrins, metalloproteinases and VEGFRs in angiogenesis in vitro and in lymphangiogenesis in vitro and in vivo. PhD obtained in September 2005 - Jean-Christoph Tille, MD (Department of Morphology). Thesis entitled: Le rôle des récepteurs à VEGF dans la régulation de l‟angiogenèse. PhD obtained in October 2003 - Stefano Mandriota (Department of Morphology). Thesis entitled: Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin family members. PhD obtained in September 1999
MD student Geneva University Hospital, Switzerland - Pierre Quinodoz (Plastic and Reconstructive Surgery) Thesis entitled: Amélioration de la survie des lambeaux cutanés: une nouvelle technique utilisant des cellules encapsulées transfectées avec bFGF. MD obtained in 1999
Post-doctoral students Department of Immunology, University of Pretoria - Ahmed Oloyo (Department of Immunology, University of Pretoria) 2014-present - Melvin Ambele (Department of Immunology, University of Pretoria) 2014-present - Shanthi Sharon Kappala (Department of Immunology, University of Pretoria) 2013-present - Cheryl Stewart (Department of Immunology, University of Pretoria) 2012-present - Marco Alessandrini (Department of Immunology, University of Pretoria) 2011-present - Christa Durandt (Department of Immunology, University of Pretoria) 2006-2007; 2012-2013 - Marnie Potgieter (Department of Immunology, University of Pretoria) 2010-2013 - Heidi Fickl (Department of Immunology, University of Pretoria) 2008-2009 Department of Morphology/Cell Physiology and Metabolism, Geneva University Medical Center - Jillian Harrison (Serono Pharmaceutical Research Institute, Geneva, Switzerland). 2003-2004 - Raphaële Buser (Serono Pharmaceutical Research Institute, Geneva, Switzerland). 2002-2004 - Kai-Uwe Schlaudraff (Plastic & Reconstructive Surgery, Geneva University Hospital). 2000-2002 - Lin Cui (Institute of Molecular Cell Biology, University of Singaopre). 2000-2002 - Navid Alizadeh (Plastic and Reconstructive Surgery, Geneva University Hospital). 1998-2000 - Ghamartaj Hosseini (Obstetrics and Gynecology, Geneva University Hospital). 1997-2000 - Lee Gorden (University of Minnesota, Minneapolis, MN, USA). 1994-1996 - Ginetta Collo (Scripps Research Institute, La Jolla, CA, USA). 1995 - Nicola Maggiano (University of Rome, Italy). 1986-1987
Thesis co-supervisor Doctoral students - Nicolaas Pool (D. Tech Biomedical Technology, Tshwane University of Technology) 2014-present - 16 - - Johan Viljoen (Department of Electrical, Electronic and Computer Engineering, University of Pretoria) 2014-present - Belinda Bunn (Dept of Oral Pathology, University of Pretoria) 2014-present - Joji Theron (Department of Physiology, University of Pretoria) 2012-present - Renier Myburgh (Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich) 2009-present - Dominik Lévigne (Department of Plastic and Reconstructive Surgery, University of Geneva). Thesis entitled: More than a nutrient: the role of oxygen in the pathophysiology and therapy of chronic wounds in ischemic and hyperglycemic conditions. PhD obtained in October 2014 MSc students - Karel de Bruin (Department of Electrical, Electronic and Computer Engineering, University of Pretoria) 2014-present - Melanie Skeen (Department of Physiotherapy, University of Pretoria) 2009-present MMed students - Keshree Gayaparsad (Institute of Pathology, University of Pretoria). Thesis entitled: An immunohistopathological review of vascular malformations and other vascular lesions using novel lymphatic specific endothelial markers Podoplanin and D2-40. MMed (Anatomical Pathology) obtained in 2007 LLM students - Safia Mahomed (Department of Jurisprudence, Unisa). Thesis entitled: A legal framework for the regulation of stem cell research and therapy in South Africa. LLM obtained in 2013 Honours students - Janis von Johannides (Dept of Pharmacology, University of Pretoria) 2014 - Karel de Bruin (Department of Electrical, Electronic and Computer Engineering, University of Pretoria) 2013 - Kristen Klose (Graduate School of Technology Management, University of Pretoria). Thesis entitled: Understanding Technology Transfer at Higher Education Institutes (HEIs): A South African Study. Degree obtained in 2010
Prizes awarded to post-graduate students
Dr. Pierre Quinodoz Swiss Society for Plastic Reconstructive and Aesthetic Surgery. Title of presentation: Amélioration de la survie des lambeaux cutanés: une nouvelle technique utilisant des cellules encapsulées transfectées. 1999.
Dr. Navid Alizadeh Swiss Society for Plastic Reconstructive and Aesthetic Surgery. Title of presentation: Active-site inactivated FVIIa (FVIIai) increases survival in a random skin falp model of acute ischemia. 2001.
Dr Jean-Christophe Tille Prix Arditi de la Faculté de Médecine de Genève. For PhD thesis entitled “Le rôle des récepteurs à VEGF dans la régulation de l‟angiogenèse”. 2005.
Dr. Ajay Mahajan Progressive tissue injury in burns is reduced by rNAPc2. Prize for the best paper at the British Burns Association (BBA) meeting. York, UK, April 2005.
Peace Mabeta 1. South African Women in Science Award, Gender responsive research. Finalist (second place). 2005. 2. Microscopy Society of Southern Africa, Innovative Research. 1st position. 2006. 3. Junior researcher of the year, 3rd Place. Faculty of Health Sciences, University of Pretoria, 2007. 4. Best publication, basic sciences category. Faculty of Health Sciences, University of Pretoria. 2010. 5. Best overall publication, non-clinical. Faculty of Health Sciences, University of Pretoria. 2012.
Tyren Dodgen 1. Best oral presentation, 2nd place. Utilization of the Roche Amplichip platform for pre-prescription genotyping. South African Genetics Society (SAGS) Congress, Pretoria, 2008. - 17 - 2. Best junior researcher, 2nd place. Phenotyping of CYP450-mediated drug metabolism in a demographically representative sample of the South African population. Faculty Day, University of Pretoria, 2008. 3. Young Scientist Award, 2nd place. Drug metabolite phenotyping of CYP2D6 and CYP2C19 enzyme activity in a demographically representative sample of the South African population. South African Society for Basic and Clinical Pharmacology congress, Rhodes University, 2008. 4. Best junior researcher, 1st place. Pre-prescription genotyping of CYP2D6 and CYP2C19 in a demographically representative group of the South African population. Faculty Day, University of Pretoria, 2009. 5. Young Scientist Award, 2nd place. Genotype vs. phenotype and the allelic variation of CYP2D6 and CYP2C19 in a demographic sample of the South African population. International Congress on Pharmaceutical and Pharmacological Science, University of the North West.2009. 6. Best PhD oral presentation, 2nd place. Is the Roche AmpliChip CYP450 Test the correct pharmacogenetic screening assay for CYP2D6 and CYP2C19 in the South African population? South African Genetics Society (SAGS) Congress, Bloemfontein. 2010. 7. Best junior researcher, 3rd place. Pharmacogenetics of CYP2C19 for personalising medication in the South African population. Faculty Day, University of Pretoria, 2010.
Dr. Marnie Potgieter 1. Junior researcher, basic science, 3rd prize: Human mesenchymal stem cells: isolation, characterization and differentiation (M Potgieter, F van Vollenstee, K Kallmeyer, C Jackson, C Dessels, MS Pepper), Faculty Day, University of Pretoria, 31 August 2011. 2. Junior researcher, basic science, 3rd prize: The effect of light activation on mesenchymal stem cell phenotype (M Potgieter, C Durandt, D de Villiers, MS Pepper), Faculty Day, University of Pretoria, 29 August 2012.
Fiona van Vollenstee 1. Basic sciences posters, 2nd prize (joint award): Evaluation of the PROCLEIX ULTRIO Plus assay for the detection of HIV-1 in the umbilical cord- and adipose tissue derived mesenchymal stem cells (F Van Vollenstee, L Gaggia, D Hoffman, K Kallmeyer, M Potgieter, P Coetzee, M Vermeulen, MS Pepper). Faculty Day, University of Pretoria, 20-21 August 2013.
Karel de Bruyn 1. Students posters, 3rd prize (joint award): A theoretical probabilistic approach to mesenchymal stem cell proliferation modelling (K De Bruin, M Potgieter, P de Villiers, MS Pepper). Faculty Day, University of Pretoria, 20-21 August 2013.
Melanie Skeen 1. Best platform presentation, 3rd prize: A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury (M Skeen, C Eksteen, MS Pepper). 52nd International Spinal Cord Society Annual Scientific Meeting, Istanbul, Turkey, 28-30 October 2013.
Karlien Kalmeyer 1. Basic sciences posters, 1st prize: Differences in Basic Biological Characteristics Exist Between Adipose- and Wharton‟s Jelly-Derived Mesenchymal Stromal Cells (K Kallmeyer, FA van Vollenstee, C Durandt, M Potgieter, MS Pepper). Faculty Day, University of Pretoria, 19-20 August 2014.
Dr. Marco Alessandrini 1. Basic sciences posters, 3rd prize: Mesenchymal Stem Cell Therapy: Overview of Clinical Indications (M Alessandrini, M Potgieter, MS Pepper). Faculty Day, University of Pretoria, 19-20 August 2014.
Renier Myburgh 1. Posters, 2nd prize. Gene engineering an HIV resistant immune system (R Myburgh, MS Pepper, P Salmon, KH Krause and RF Speck RF). World Innovation Day “Innovation for Health Competition”, Geneva, Switzerland, 28‐29 August 2014.
Antoinette Colic - 18 - 1. Oral presentation, 1st prize. Pharmacogenetics of CYP2B6, 2A6 and UGT2B7: relevance to HIV treatment in African populations (A Colic, M Alessandrini and MS Pepper). Genomics Research Institute Seminar Day, University of Pretoria, 31 October 2014.
EXTERNAL EXAMINER
Undergraduate course external examiner
Midrand Graduate Institute - Medical Biotechnology course (2008-2009)
University of the Witwatersrand - Molecular Medicine course for second year MBBCh students (2009-present) - School of Animal, Plant and Environmental Sciences (2010)
PhD Thesis examiner - Britt Ingrid Drögemöller, Stelenbosch University (South Africa). October 2013. Thesis title: Investigation of genetic variation contributing to antipsychotic treatment response in a South African first episode schizophrenia cohort. - Anabela Correira Pereira Picton, University of the Witwatersrand (South Africa). May 2013. Thesis title: HIV-1 coreceptor CCR5: gene characterization anmd expresion. - H. J. Kotzé, North-West University (South Africa). July 2010. Thesis title: Evaluation of specific genotypes in the context of the type 2 diabetes risk phenotype in the black South African population. - Dr. Benoit Jenny, University of Geneva (Switzerland). July 2010. Thesis title: A neural stem/progenitor cell based approach for brain repair. - Fabienne Baffert, Université Joseph Fourier Grenoble I (Grenoble). March 2001. Thesis title: Effets d‟une exposition prolongée à l‟hypoxie sur la réorganisation des cellules endothéliales ensemencées sur matrice de fibrine. - Etienne Régulier, Université Louis Pasteur (Strasbourg). January 2001. Thesis title: Thérapie génique du cancer par transfert adénoviral de genès codant des chimiokines, cytokines et facteurs anti-angiogéniques. - Thomas Christen, Université de Genève (Switzerland). November 2000. Thesis title: Porcine coronary artery smooth muscle cells: phenotypic features and implication in restenosis. - Ingrid Struman, Université de Liège (Belgium). May 1999. Thesis title: Etude des propriétés angiogéniques des membres de la famille prolactine/hormone de croissance humanie et de leurs fragments N-terminaux de 16 kDa. - Arianna Caprioli, Université de Paris 6 (France). December 1997. Thesis title: L‟allantoïde, un des sites de production de cellules souches hématopoïétiques et de progéniteurs endothéliaux chez l‟embryon d‟Oiseau.
LLD Thesis examiner - Paul Tobias Mtunuse, University of South Africa (South Africa). May 2013. Thesis title: The right to confidentiality in the context of HIV/AIDS.
Habilitation Thesis examiner - Anne Eichmann, Institut d‟Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne, et Université de Marne-la Vallée (France). Mémoire d‟habilitation à diriger des recherches (HDR): Caracterisation moléculaire des précurseurs vasculaires embryonnaires. 1 December 2000. - Luc Pardanaud, Institut d‟Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne, et Université de Marne-la Vallée (France). Mémoire d‟habilitation à diriger des recherches (HDR): Aspects Cellulaires et Moléculaires du Developpement Vasculaire. 1 December 2000.
Other - Florence Gandillon, Swissbody Pilates, Geneva (Switzerland). Mémoire : La méthode Pilates dans un contexte de post- reeducation suite à une tetraparesie. 28 April 2013.
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RESEARCH
RESEARCH FUNDING
Project title or student name Funding body Amount Date Notes Study of the transcriptome National Health R 491 600 2015 profiles of mesenchymal stem Laboratory Services cells from human tissues Research Trust Extramural Unit: Stem Cell South Afrcian Medical R 1 000 000 04/2015 Research and Therapy Research Council for 5 years Fluidigm C1/Biomark single National Research R 11 970 000 2014/2015 Includes 1/3 cell transcriptomics and Foundation: contribution from genomics platform Infrastructure Funding UP Instruments (NEP/NNEP) Dr Sharon Kappala University of Pretoria R 200 000pa 2 years Personal use Vice-Chancellor's 2013-2015 Post-Doctoral Fellowship Programme Dr Ahmed Oloyo University of Pretoria R 200 000pa 2 years Personal use Vice-Chancellor's 2014-2016 Post-Doctoral Fellowship Programme Karlien Kallmeyer National Research R 100 000pa 3 years Personal use Foundation Scarce 2014-2016 Skills Development Fund Doctoral Scholarship Karlien Kallmeyer Ernst and Ethel R 12 000 2014 Personal use Eriksen Trust PhD bursary Lara Contu Deutscher R 90 000pa 3 years Personal use Akademischer 2014-3016 Austausch Dienst (German Academic Exchange Service) PhD bursary Elize Wolmarans National Research R 92 347.20 2014-2015 Personal use Foundation Internship Sasha Reznichenko National Research R 92 347.20 2014-2015 Personal use Foundation Internship Transcriptome analysis of Institutional Research R 84 000 2014 hematopoietic stem cells Theme for Genomics, expanded in culture University of Pretoria FacsAria Fusion Cell Sorter National Research R 12 084 000 2014 Includes 1/3 Foundation: contribution from Infrastructure Funding UP Instruments (NEP/NNEP) Evaluation of the National Health R 90 000 2014-2016 effectiveness of a microarray Laboratory Services based diagnostic tool Research Trust (AMLprofiler) for acute - 20 - myeloid leukaemia (AML) relative to current diagnostic modalities in the South African context Stem cell research and Medical Research R 16 500 000 2014-2016 Category 1 award therapy: addressing South Council: SA Africa‟s disease burden University Flagship Projects Gene engineering HIV Swiss South African R 1 200 000 2014-2016 Co-applicant with resistant cells Joint Research Profs. Roberto Programme Speck (Zurich) and Krause (Geneva) Development of National Research R 931 000 2013-2015 Co-applicant with computational resources to Foundation: National Prof. Alan support analysis of Southern Bioinformatics Christoffels and the African Human genomes Functional Genomics Southern African Programme (NBIG) Human Genome Programme Mesenchymal stem cell National Research R 317 470 2013-2015 transcriptome analysis Foundation: National Bioinformatics Functional Genomics Programme (NBIG) Genomics research on Wellcome Trust R 70 000 2013 indigenous populations: exploring the concept of genomic sovereignty with the San community of southern Africa Carla Dessels Deutscher R 60 000pa 2013-2104 Personal use Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary Jeanne van Rensburg National Research R 72 600 2013-2014 Personal use Foundation Internship Juanita Mellet National Research R 100 000pa 2013-2015 Personal use Foundation Innovation Doctoral Scholarship Danielle de Villiers Faculty of Health R 40 000 2013 Personal use Sciences, University of Pretoria - Research Assistant post Isabella Rangaka Faculty of Health R 40 000 2013 Personal use Sciences, University of Pretoria - Research Assistant post Cell delivery for soft tissue Council for Scientific R 30 000 2013 augmentation and Industrial Research A molecular investigation of University of Pretoria R 100 000 2013 cystic fibrosis in South Africa A molecular investigation of Institutional Research R 167 120 2013 cystic fibrosis in South Africa Theme for Genomics, University of Pretoria - 21 -
Dr. Cheryl Stewart University of Pretoria R 200 000pa 2012-2014 Personal use Vice-Chancellor's Post-Doctoral Fellowship Programme Madelein-Meissner Roloff Faculty of Health R 40 000 2012 Personal use and Karnien Kallmeyer Sciences, University of Pretoria - Research Assistant post Jeanne van Rensberg Faculty of Health R 40 000 2012 Personal use Sciences, University of Pretoria - Research Assistant post Southern African Human Department of Science R 2 000 000 2012 Co-applicant with Genome Programme and Technology Prof. Michele Ramsay Public cord blood bank Medical Research R 322 660 2012 feasibility study Council Isabella Rangaka Medical Research R 60 000 2012 Personal use Council Juanita Mellet and Danielle de National Research R 144 000 2012-2013 Personal use Villiers Foundation Internship Dr. Marco Alessandrini National Research R 190 000pa 2012-2014 R 160 000 personal Foundation Scarce use Skills Development R 30 000 research Fund Dr. Chrisna Durandt University of Pretoria R 150 000pa 2012-2013 Personal use Clinical research co- ordinator Dr. M. Potgieter University of Pretoria R 680 000 2010-2013 Personal use Research Fellowship Programme Dr. M. Potgieter Medical Research R 250 000 2011-2012 Personal use Council Post-doctoral scholarship Tyren Dodgen Deutscher R 65 000 2011 Personal use Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary Isabella Rangaka National Research R 87 120 2011-2012 Personal use Foundation Internship Karlien Kallmeyer National Research R 60 000pa 2011-2012 Personal use Foundation Free- standing and Innovation Scholarship Carlo Jackson Deutscher R 65 000pa 2011-2014 Personal use Akademischer Austausch Dienst (German Academic Exchange Service) PhD bursary Fiona van Vollenstee Faculty of Health R 40 000 2011 Personal use Sciences, University - 22 -
of Pretoria - Research Assistant post Carlo Jackson and Karlien Faculty of Health R 40 000 2011 Personal use Kallmeyer Sciences, University of Pretoria - Research Assistant post Southern African Human Department of Science R 450 000 2010-2011 Co-applicant with Genome Programme and Technology Prof. Michele Ramsay Soft tissue augmentation – Council for Scientific R 150 000 2010-2011 cell delivery using and Industrial DermapearlTM Research Carlo Jackson Faculty of Health R 40 000 2010 Personal use Sciences, University of Pretoria - Research Assistant post Karlien Kallmeyer, Fiona van National Research R 132 000 2010-2011 Personal use Vollenstee Foundation Internship Fatima Barmania Innovation Master‟s R 60 000 2010 - Personal use Scholarship 2011 Cytochrome P450 2D6 National Health R 324 500 2010-2011 polymorphisms in weight gain Laboratory Services and movement disorders Research Trust associated with risperidone treatment Gene therapy for HIV/AIDS National Research R 1 920 000 2009-2011 Foundation Arinda Eloff, Amy Kopke National Research R 132 000 2009-2010 Personal use Foundation Internship Understanding technology World Bank Institute R 85 000 2009 transfer at South African universities: towards establishing trends and best practice for the establishment of Communities of Practice among Southern African and African universities Investigation of MC4 receptor National Health R 51 300 2009 polymorphisms in the South Laboratory Services African obese population Research Trust CYP2D6 polymorphisms National Research R 200 000 2008-2009 associated with risperidone Foundation - Unlocking the future CYP2D6 and CYP2C19 National Research R 209 000 2007-2008 pharmacogenetics as a pre- Foundation - Focus prescription predictive tool for Area Call drug toxicity and efficacy in the South African population Pharmacogenetics of CYP2D6 National Research R 151 000 2007 Awarded to Dr. and CYP2C19 Foundation - Chrisna Durandt Thuthuka. Women in research Utilization of AmpliChip AMPATH National R 648 000 2006-2009 pharmacogenetic technology Pathology Support for pre-prescription Services genotyping - 23 -
Dr. Chrisna Durandt University of Pretoria, R 330 000 2006-2008 Pretoria, Research Fellowship Pre-treatment genotyping as a National Health R 60 000 2006 predictor of therapeutic Laboratory Services outcome Research Trust Molecular mechanisms of Swiss National SFr 319 925 2004-2007 Grant returned to lymphangiogenesis and Science Foundation the Swiss National lymphatic tumor cell Science Foundation dissemination because of departure from Switzerland Genomic analysis of Merck KGaA, € 184 800 2003-2005 endothelial cells during Darmstadt, Germany angiogenesis Lymphatic endothelial cells: Novartis Pharma AG, SFr 211 716 2003-2004 isolation, characterisation and Basel, Switzerland development of functional assays Effect of SSR128129, an Sanofi-Synthelabo SFr 62 666.24 2003 FGF-R1 antagonist, on Recherche, Toulouse, angiogenesis in vitro and France lymphangiogenesis and tumor metastasis in vivo Pathophysiology and Société Académique SFr 15 000 2002 consequences of tissue de Genève ischemia Effects of 8-prenylnaringenin, Swiss Foundation for SFr 20 000 2002 a novel highly phytoestrogen, Nutrition Research on angiogenesis and the endothelial cell proteolytic repertoire Evaluation of rNAPc2 in Corvas International SFr 43 000 2002 random dorsal skin flap model Inc of acute ischemia Pathophysiology and Crédits SFr 40 000 2002 consequences of tissue d‟investissement de la ischemia Faculté de Médecine, Université de Genève Hypoxia-regulated gene Fondation Novartis SFr 43 157 2001 expression in endothelial cells – a therapeutic target ? Mechanisms of Swiss National SFr 335 000 2001-2004 lymphangiogenesis and its Science Foundation role in tumor metastasis Genomic analysis of Merck KGaA, € 153 387 2000-2002 endothelial cells during Darmstadt angiogenesis Hypoxia-regulated gene Recherche Suisse SFr 139 500 2000-2002 expression in endothelial cells Contre le Cancer - a therapeutic target? Hypoxia-regulated gene Rentenanstalt Swiss SFr 20 000 2000 expression in endothelial cells Life - a therapeutic target? Regulation of angiogenesis: Fondation Suisse de SFr 125 000 2000 the role of endothelial- Cardiologie - 24 - perivascular cell interactions and hypoxia Angiogenesis and vascular Fondation SFr 23 327 1999 morphogenesis Schmidheiny Positive and negative Fondation Carlos et SFr 25 000 1997 regulation of angiogenesis: Elise de Reuter clinical applications of basic science research Establishing an "angiogenic Ligue Genevoise SFr 19 517.25 1996 profile" for cancer patients contre le Cancer Angiogenesis and Fondation Sandoz SFr 25 000 1994 tubulogenesis in the rodent pour l'avancement des mammary gland and sciences medico- endocrine pancreas biologiques Co-applicant with Dr. M.-L. Bochaton-Piallat (Dept. Pathology, University Medical Center, Geneva, Switzerland) Arterial smooth muscle Swiss National SFr 227 000 2002-2005 heterogeniety: implications Science Foundation for atherosclerosis and restenosis Co-applicant with Dr. B. Pittet-Cuenod (Div. Plastic and Reconstructive Surgery, Geneva University Hospital, Geneva, Switzerland) Improving survival and repair Swiss National SFr 167 000 2002-2005 of ischemic tissue Science Foundation Improving the survival of skin Swiss National SFr 206 250 1998-2001 grafts and skin flaps Science Foundation Co-applicant with Dr. C. Morel (Institut de Physique des Hautes Eneries, Université de Lausanne, Lausanne, Switzerland) Design and construction of a Swiss National SFr 769 982 2001-2003 high resolution PET camera Science Foundation for small animals. Co-applicant with Dr. M.-A. Brundler (Division of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland) Angiogenesis, a possible Ligue Genevoise SFr 57 000 1998/1999 prognostic marker in Barrett‟s contre le Cancer esophagus, Barrett‟s dysplasia and adenocarcinoma of the lower esophagus and gastric cardia? Co-applicant with Dr. R. Montesano (Dept. Morphology, University of Geneva Medical Center, Geneva, Switzerland) Molecular mechanisms of Swiss National SFr 750 000 1995-2000 capillary and epithelial Science Foundation morphogenesis Molecular mechanisms of Swiss National SFr 524 000 1992-1995 capillary and epithelial Science Foundation morphogenesis Analyse moléculaire du Société Académique SFr 15 970 1990 processus de néoformation de de Genève vaisseaux sanguins Molecular mechanisms of Swiss National SFr 300 000 1989-1992 angiogenesis in vitro Science Foundation Studies on the molecular Sir Jules Thorn SFr 90 870 1988-1991 mechanisms of the Charitable Overseas neovascularization process Trust (angiogenesis) - 25 -
Mechanisms and regulation of Juvenile Diabetes $ 79 950 1988-1989 blood capillary proliferation Foundation in diabetes: an in vitro International approach Analyse moléculaire du Bal de Genève en SFr 49 000 1988 processus de faveur de la Recherche néovascularisation des sur le Cancer tumeurs
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MICHAEL PEPPER THESES
PhD Thesis
Faculty of Science, University of Geneva, 1990. "Invasive properties of endothelial cells: contributions to the process of angiogenesis." Thesis no. 2421, 150 pages.
MD Thesis
Faculty of Medicine, University of Geneva, 1992. "Angiogenesis in vitro: interactions between angiogenesis-modulating cytokines and the role of balanced extracellular proteolysis." Thesis no. 9398, 120 pages.
Privat Docent Thesis
Faculty of Medicine, University of Geneva, 1997. "Positive and negative regulation of angiogenesis: from cell biology to the clinic." 203 pages.
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PUBLICATIONS
Original Publications (peer review journals)
Total impact factor: 653.53 Number of publications: 121 (9 without IF) Mean impact factor per publication: 5.84 (As of June 2014)
No. Authors Title Journal Impact Factor 1 Montesano R., Pepper M.S., Phorbol ester induces cultured J. Cell. Physiol. 4.218 Vassalli J.-D. and Orci L. endothelial cells to invade a fibrin 132: 509-516 (1987). matrix in the presence of fibrinolytic inhibitors. 2 Pepper M.S., Vassalli J.-D., Urokinase-type plasminogen activator J. Cell Biol. 10.822 Montesano R. and Orci L. is induced in migrating capillary 105: 2535-2541 endothelial cells. (1987). 3 Montesano R., Pepper M.S., Induction of angiogenesis in vitro by J. Cell. Physiol. 4.218 Belin D., Vassalli J.-D. and Orci vanadate, an inhibitor of 134: 460-466 (1988). L. phosphotyrosine phosphatases. 4 Pepper M.S., Spray D.C., Junctional communication is induced J. Cell Biol. 10.822 Chanson M., Montesano R., in migrating capillary endothelial 109: 3027-3038 Orci L. and Meda P. cells. (1989). 5 Pepper M.S., Belin D., Transforming growth factor-beta 1 J. Cell Biol. 10.822 Montesano R., Orci L. and modulates basic fibroblast growth 111: 743-755 (1990). Vassalli J.-D. factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. 6 Montesano R., Pepper M.S., Increased proteolytic activity is Cell 31.957 Möhle-Steinlein U., Risau W., responsible for the aberrant 62: 435-445 (1990). Wagner E.F. and Orci L. morphogenetic behaviour of endothelial cells expressing the middle T oncogene. 7 Meda P., Chanson M., Pepper In vivo modulation of connexin 43 Exp. Cell Res. 3.557 M., Giordano E., Bosco D., gene expression and junctional 192: 469-480 (1991). Traub O., Willecke K., El coupling of pancreatic B-cells. Aoumari A., Gros D., Beyer E.C., Orci L. and Spray D.C. 8 Pepper M.S., Montesano R., Chondrocytes inhibit endothelial J. Cell. Physiol. 4.218 Vassalli J.-D. and Orci L. sprout formation in vitro: evidence for 146: 170-179 (1991). involvement of a transforming growth factor-beta. 9 Pepper M.S., Montesano R., Plasminogen activator inhibitor-1 is Biochem. Biophys. 2.406 Orci L. and Vassalli J.-D. induced in microvascular endothelial Res. Commun. cells by a chondrocyte-derived 176: 633-638 (1991). transforming growth factor-beta. 10 Pepper M.S., Ferrara N., Orci L. Vascular endothelial growth factor Biochem. Biophys. 2.406 and Montesano R. (VEGF) induces plasminogen Res. Commun. activators and plasminogen activator 181: 902-906 (1991). inhibitor-1 in microvascular endothelial cells. 11 Pepper M.S., Montesano R., El Coupling and connexin 43 expression Am. J. Physiol. 3.711 Aoumari A., Gros D., Orci L. in microvascular and large vessel 262 (Cell Physiol. - 28 -
and Meda P. endothelial cells. 31): C1246-C1257 (1992). 12 Pepper M.S., Matsumoto K., Hepatocyte growth factor increases J. Biol. Chem. 4.651 Nakamura T., Orci L. and urokinase-type plasminogen activator 267: 20493-20496 Montesano R. (u-PA) and u-PA receptor expression (1992). in Madin-Darby canine kidney epithelial cells. 13 Pepper M.S., Sappino A.-P., Plasminogen activator inhibitor-1 is J. Cell. Physiol. 4.218 Montesano R., Orci L. and induced in migrating endothelial cells. 153: 129-139 (1992). Vassalli J.-D. 14 Pepper M.S. and Meda P. Basic fibroblast growth factor J. Cell. Physiol. 4.218 increases junctional communication 153: 196-205 (1992). and connexin 43 expression in microvascular endothelial cells. 15 Pepper M.S., Ferrara N., Orci L. Potent synergism between vascular Biochem. Biophys. 2.406 and Montesano R. endothelial growth factor and basic Res. Commun. fibroblast growth factor in the 189: 824-831 (1992). induction of angiogenesis in vitro. 16 Pepper M.S., Vassalli J.-D., Biphasic effect of TGF1 on in vitro Exp. Cell Res. 3.557 Orci L. and Montesano R. angiogenesis. 204: 356-363 (1993). 17 Fotsis T., Pepper M., Genistein, a dietary-derived inhibitor Proc. Natl. Acad. 9.737 Aldercreutz H., Fleischmann G., of in vitro angiogenesis. Sci. USA Hase T., Montesano R. and 90: 2690-2694 Schweigerer L. (1993). 18 Pepper M.S., Sappino A.-P., Upregulation of urokinase receptor J. Cell Biol. 10.822 Stocklin R., Montesano R., Orci expression on migrating endothelial 122: 673-684 (1993). L. and Vassalli J.-D. cells. 19 Montesano R., Pepper M.S. and Paracrine induction of angiogenesis in J. Cell Sci. 5.877 Orci L. vitro by Swiss 3T3 fibroblasts. 105: 1013-1024 (1993). 20 Meda P., Pepper M.S., Traub Differential expression of gap junction Endocrinology 4.717 O., Willecke K., Gros D., Beyer connexins in endocrine and exocrine 133: 2371-2378 E., Nicholson B., Paul D. and glands. (1993). Orci L. 21 Pepper M.S., Wasi S., Ferrara In vitro angiogenic and proteolytic Exp. Cell Res. 3.557 N., Orci. L and Montesano R. properties of bovine lymphatic 210: 298-305 (1994). endothelial cells. 22 Fotsis T., Zhang Y., Pepper The endogenous estrogen metabolite Nature 38.597 M.S., Aldercreutz H., 2-methoxyestradiol inhibits 368: 237-239 (1994). Montesano R. Nawroth P.P. and angiogenesis and suppresses tumor L. Schweigerer. growth. 23 Pepper M.S., Vassalli J.-D., Modulation of bovine microvascular J. Cell. Biochem. 3.062 Wilks J.W., Schweigerer L., endothelial cell proteolytic properties 55: 419-434 (1994). Orci. L and Montesano R. by inhibitors of angiogenesis. 24 Pepper M.S., Ferrara N., Orci L. Leukemia inhibitory factor (LIF) J. Cell Sci. 5.877 and Montesano R. inhibits in vitro angiogenesis. 108: 73-83 (1995). 25 Soriano, J.V., Pepper M.S., Hepatocyte growth factor stimulates J. Cell Sci. 5.877 Nakamura T., Orci. L and extensive development of branching 108: 413-430 (1995). Montesano R. duct-like structures by cloned mammary gland epithelial cells. 26 Mandriota S.J., Seghezzi G., Vascular endothelial growth factor J. Biol. Chem. 4.651 Vassalli J.-D., Ferrara N., Wasi increases urokinase receptor 270: 9709-9716 S., Mazzieri R., Mignatti P. and expression in vascular endothelial (1995). Pepper M.S. cells. 27 Pepper M.S., Soriano J.V., Modulation of hepatocyte growth Exp. Cell Res. 3.557 Menoud P.-A., Sappino A.-P., factor and c-met expression in the rat 219: 204-210 (1995). - 29 -
Orci, L. and Montesano R. mammary gland during pregnancy, lactation and involution. 28 Mandriota S.J., Menoud P.-A. Transforming growth factor 1 down- J. Biol. Chem. 4.651 and Pepper M.S. regulates vascular endothelial growth 271: 11500-11505 factor receptor-2/flk-1 expression in (1996). vascular endothelial cells. 29 Montesano R., Kumar S., Orci Synergistic effect of hyaluronan Lab. Invest. 3.961 L., and Pepper M.S. oligosaccharides and vascular 75: 249-262 (1996). endothelial growth factor on angiogenesis in vitro. 30 French L.E., Soriano J.V., Modulation of clusterin gene Biol. Reprod. 4.027 Montesano R. and Pepper M.S. expression in the rat mammary gland 55: 1213-1220 during pregnancy, lactation and (1996). involution. 31 Zimrin A.B., Pepper M.S., An antisense oligonucleotide to the J. Biol. Chem. 4.651 McMahon G.A., Nguyen F., notch ligand Jagged enhances 271: 32499-32502 Montesano R., Maciag T. fibroblast growth factor-induced (1996). angiogenesis in vitro. 32 Thommen R., Humar R., PDGF-BB increases endothelial J. Cell. Biochem. 3.062 Misevic G., Pepper M.S., Hahn migration and cord movements during 64: 403-413 (1997). A.W.A., John M. and Battegay angiogenesis in vitro. E.J. 33 Gorden, D.L., Mandriota S.J., Vascular endothelial growth factor is Transplantation 3.781 Montesano R., Orci L. and increased in devascularized rat islets 63: 436-443 (1997). Pepper M.S. of Langerhans in vitro. 34 Anande-Apte B., Pepper M.S., Inhibition of angiogenesis by tissue Invest. Ophth. Vis. 3.441 Voest E., Montesano R., Olsen inhibitor of metalloproteinase-3 Sci. 38: 817-823 B., Murphy G., Apte S.S. and (TIMP-3). (1997). Zetter B. Anande-Apte B., Pepper M.S., Untitled - reply Invest. Ophth. Vis. Voest E., Montesano R., Olsen Sci. 38: 2433-2434 B., Murphy G., Apte S.S. and (1997). Zetter B. 35 Sabapathy K.T., Pepper M.S., Polyoma middle T-induced vascular J. Cell Biol. 10.822 Kiefer F., Möhle-Steinlein U., tumor formation: the role of the 137: 953-963 (1997). Tacchini-Cottier F., Fetka I., plasminogen activator/plasmin system. Breier G., Risau W., Montesano R. and Wagner E.F. 36 Fotsis T., Pepper M.S., Aktas Flavonoids, dietary-derived inhibitors Cancer Res. 8.650 E., Breit S., Rasku S., of cell proliferation and in vitro 57: 2916-2921 Adlercreutz H., Wähälä K., angiogenesis. (1997). Montesano R. and Schweigerer L. 37 Masouyé I., Hagens G., Van Endothelial cells of the human Circ. Res. 11.861 Kuppevelt T.H., Madsen P., microvasculature express epidermal 81: 297-303 (1997). Saurat J.-H., Veerkamp J.H., fatty acid-binding protein. Pepper M.S. and Siegenthaler G. 38 Mandriota S.J. and Pepper M.S. Vascular endothelial growth factor- J. Cell Sci. 5.877 induced in vitro angiogenesis and 110: 2293-2302 plasminogen activator expression are (1997). dependent on endogenous basic fibroblast growth factor. 39 Terris B., Scoazec J.-Y., Rubbia Expression of vascular endothelial Histopathology. 2.857 L., Bregeaud L., Pepper M.S., growth factor in digestive 32:133-138 (1998). Ruszniewski P., Belghiti J., neuroendocrine tumors. - 30 -
Fléjou J.-F. and Degott C. 40 Bochaton-Piallat M.-L., Plasminogen activator expression in Circ. Res. 11.861 Gabbiani G. and Pepper M.S. rat arterial smooth muscle cells 82: 1086-1093 depends on their phenotype and is (1998). modulated by cytokines. 41 Pepper M.S. and Mandriota S.J. Regulation of vascular endothelial Exp. Cell Res. 3.557 growth factor receptor-2 (Flk-1) 241: 414-425 (1998). expression in vascular endothelial cells. 42 Cavallaro U., Wu Z.-H., Di Palo Fibroblast growth factor-2 stimulates FASEB J. 5.704 A., Montesano R., Pepper M.S., migration of Kaposi‟s sarcoma-like 12: 1027-1034 Maier J.A.M. and Soria M.R. vascular spindle cells by HGF- (1998). dependent relocalization of the urokinase receptor. 43 Mandriota S.J. and Pepper M.S. Regulation of angiopoietin-2 mRNA Circ. Res. 11.861 levels in bovine microvascular 83: 852-859 (1998). endothelial cells by cytokines and hypoxia. 44 Olofsson B., Korpelainen E., VEGF-B binds to VEGFR-1 and Proc. Natl. Acad. 9.737 Pepper M.S., Mandriota S.J., regulates plasminogen activator Sci. USA. 95: 11709- Aase K., Kumar V., Gunji Y., activity in endothelial cells. 11714 (1998). Jeltsch M.., Shibuya M., Alitalo K. and Eriksson U. 45 Pepper M.S., Mandriota S.J., Vascular endothelial growth factor J. Cell. Physiol. 4.218 Jeltsch M. Kumar V. and (VEGF)-C synergizes with basic 177: 439-452 (1998). Alitalo K. fibroblast growth factor and VEGF in the induction of angiogenesis in vitro, and alters endothelial cell extracellular proteolytic activity. 46 Lucas R., Garcia I., Donati Specific role of TNF receptor 2 in Eur. J. Immunol. 4.970 Y.R.A., Hribar M., Mandriota direct, but not in sensitized TNF- 28: 3577-3586 S.J., Giroud C., Buurman W.A., mediated cytotoxicity in microvascular (1998). Fransen L., Suter P.M., Nuñez endothelial cells. G., Pepper M.S. and Grau G.E. 47 Lucas R., Holmgren L., Garcia Multiple forms of angiostatin induce Blood 9.060 I., Jiminez, B., Mandriota S.J., apoptosis in endothelial cells. 92: 4730-4741 Borlat F., Sim B.K.L., Wu Z., (1998). Grau G.E., Shing Y., Soff G.A., Bouck N. and Pepper M.S. 48 Collo G. and Pepper M.S. Endothelial cell integrin 51 J. Cell Sci. 5.877 expression is modulated by cytokines 112: 569-578 (1999). and during migration in vitro. 49 Montesano R., Soriano J.V., Constitutively active MAPK kinase Cell Growth Differ. Hosseini G., Pepper M.S. and MEK1 disrupts morphogenesis and 10: 317-332 (1999). Schramek H. induces an invasive phenotype in MDCK epithelial cells. 50 Neuville P., Yan Z., Gidlöf A., Retinoic acid regulates arterial smooth Arterioscl. Thromb. 6.338 Pepper M.S., Hansson G.K., muscle cell proliferation and Vasc. Biol. Gabbiani G. and Sirsjö A. phenotypic features in vivo and in 19: 1430-1436 vitro through a RAR-independent- (1999). signalling pathway. 51 Soriano J.V., Pepper M.S., Chromogranin A increases deposition Biochem. Biophys. 2.406 Taupenot L., Bader M.-F., Orci of basement membrane components by Res. Commun. L. and Montesano R. mammary epithelial cells. 259: 563-568 (1999). 52 Miralbell R., Tolnay M., Bieri Pediatric medulloblastoma: prognostic J. Neuro-oncol. 3.115 S., Probst A., Sappino A.-P., value of p53, bcl-2, Mib-1, and 45: 103-110 (1999). - 31 -
Berchtold W., Pepper M.S. and microvessel density. Pizzolato G.: 53 Zhao H., Bojanowski K., Ingber A new role for tRNA and its fragment J. Cell. Biochem. 3.062 D.E., Panigrahy D., Pepper purified from urinary bladder 76: 109-117 (2000). M.S., Montesano R. and Shing carcinoma conditioned medium: Y. inhibition of endothelial cell growth. 54 Fuhrmann-Benzakein E., Ma Elevated levels of angiogenic Int. J. Cancer. 6.198 M.N., Rubbia-Brandt L., cytokines in the plasma of cancer 85: 40-45 (2000). Mentha G., Rufenacht D., patients. Sappino A.-P. and Pepper M.S. 55 Tenan M., Fulci G., Albertoni Thrombospondin-1 is downregulated J. Exp. Med. 13.214 M., Diserens A.-C., Hamou M.- by anoxia and suppresses 191: 1789-1798 F., El Atifi-Borel M., Feige J.- tumorigenicity of human glioblastoma (2000). J., Pepper M.S. and van Meir cells. E.G. 56 Mandriota S.J., Pyke C., Di Hypoxia-inducible angiopoietin-2 Am. J. Pathol. 4.522 Sanza C., Quinodoz P., Pittet B. expression is mimicked by 156: 2077-2089 and Pepper M.S. diphenylene iodonium and occurs in (2000). the rat brain and skin in response to systemic hypoxia and tissue ischemia. 57 Pepper M.S., Baetens D., Regulation of VEGF and VEGF Dev. Dynam. 2.590 Mandriota S.J., Di Sanza C., receptor expression in the rodent 218: 507-524 (2000). Oikemus S., Lane T.F., Soriano mammary gland during pregnancy, J.V., Montesano R. and Iruela- lactation and involution. Arispe M.L. 58 Taraboletti G., Sonzogni L., Post-transcritpional stimulation of Exp. Cell Res. 3.557 Vergani V., Hosseini G., Ceruti endothelial cell matrix 258: 384-394 (2000). R., Ghilardi C., Bastone A., metalloproteinases 2 and 1 by Toschi E., Borsotti P., Scanziani endothelioma cells. E., Giavazzi R., Pepper M.S., Stetler-Stevenson W. and Bani M.R. 59 Cavallaro U., Castelli V., Perilli Characterization of novel clonal In Vitro Cell. Dev. 1.289 A., Dossi R., Giavazzi R., murine endothelial cell lines with an An. Pepper M.S., Soria M.R. and extended life span. 36: 299-308 (2000). Montesano R. 60 Fuhrmann-Benzakein E., Cre-mediated inducible and Nucleic Acids. Res. 8.278 Garcia-Gabay I., Pepper M.S., irreversible control of gene expression 28: e99 (5 pages) Vassalli J.-D. and Herrera P.L. using a single transgene. (2000). 61 Scheidegger P., Weiglhofer W., Signalling properties of an HIV- Biochem. J. 4.654 Suarez S., Console S., encoded angiogenic peptide mimicking 353: 569-578 (2001). Waltenberger J., Pepper M.S., vascular endothelial growth factor Jaussi R. and Ballmer-Hofer K. activity. 62 Mandriota S.J., Jussila L., Vascular endothelial growth factor-C- EMBO J. 8.822 Jeltsch M., Compagni A., mediated lymphangiogenesis promotes 20: 672-682 (2001). Baetens D., Prevo R., Banerji tumour metastasis. S., Huarte J., Montesano R., Jackson D., Orci L., Alitalo K., Christofori G. and Pepper M.S. 63 Lucas R., Montesano R., Pepper Lectin-deficient TNF mutants display Int. J. Cancer 6.198 M.S., Hafner M., Sablon E., comparable anti-tumor but reduced 91: 543-549 (2001). Dunant Y., Grau G.E., De pro-metastatic potential as compared Baetselier P., Männel D. and to the wild-type molecule. Fransen L. 64 Cavallaro U., Perilli A., Castelli FGF-2 promotes disassembly of actin Microvasc. Res. 2.929 V., Pepper M.S. and Soria M.R. cytoskeleton and shape changes in 61: 211-214 (2001). - 32 -
murine vascular cells. 65 Kwak B.R., Pepper M.S., Gros Inhibition of endothelial wound repair Mol. Biol. Cell 4.803 D.B. and Meda P. by dominant negative connexin 12: 831-845 (2001). inhibitors. 66 Rinsch C., Quinodoz P., Pittet Delivery of FGF-2 but not VEGF by Gene Ther. 4.321 B., Alizadeh N., Baetens D., encapsulated genetically engineered 8: 523-533 (2001). Montadon D., Aebischer P. and myoblasts improves survival and Pepper M.S. vascularization in a model of acute skin flap ischemia. 67 Pepper M.S., Rosnoblet C., Di Synergistic induction of tissue-type Thromb. 6.094 Sanza C. and Kruithof E.K.O. plasminogen activator (tPA) by Haemostasis vascular endothelial growth factor and 86: 702-709 (2001). basic fibroblast growth factor and localization of tPA to Weibel-Palade bodies in bovine microvascular endothelial cells. 68 Cavallaro U., Tenan M., Castelli The response of bovine endothelial J. Cell. Biochem. 3.062 V., Perilli A, Maggiano N., Van cells to FGF-2 and VEGF is dependent 82: 619-633 (2001). Meir E., Montesano R., Soria on their site of origin: relevance to the M.R., and Pepper M.S. regulation of angiogenesis. 69 Kirkin V., Mazitschek R., Characterisation of indolinones which Eur. J. Biochem. 4.250 Krishnan J., Steffen A., preferentially inhibit VEGF-C- and 268: 5530-5540 Waltenberger J., Pepper M.S., VEGF-D-induced activation of (2001). Giannis A. and Sleeman J.P. VEGFR-3 rather than VEGFR-2. 70 Tille J.-C., Wood J., Mandriota Vascular endothelial growth factor J. Pharmacol. Exp. 3.891 S.J., Schnell C., Ferrari S., (VEGF) receptor-2 antagonists inhibit Ther. Mestan J., Zhu Z., Witte L. and VEGF- and basic fibroblast growth 299: 1073-1085 Pepper M.S. factor-induced angiogenesis in vivo (2001). and in vitro. 71 Gannon G., Mandriota S.J., Cui Overexpression of VEGF-A165 Cancer Res. 8.650 L., Baetens D., Pepper M.S. and enhances tumor angiogenesis but not 62: 603-608 (2002). Christofori G. metastasis during -cell carcinogenesis. 72 Lucas R., Lijnen H.R., Increased angiostatin levels in Thromb. 6.094 Suffredini A.F., Pepper M.S., bronchoalveolar lavage fluids from Haemostasis Steinberg K.P., Martin T.R. and ARDS patients and from human 87: 966-971 (2002). Pugin J. volunteers after lung instillation of endotoxin. 73 Hao H., Ropraz P., Verin V., Heterogeniety of smooth muscle cell Arterioscl. Thromb. 6.338 Camenzind E., Geinoz A., populations cultured from pig Vasc. Biol. Pepper M.S., Gabbiani G. and coronary artery. 22: 1093-1099 Bochaton-Piallat M.L. (2002). 74 Van Trappen P.O., Ryan A., A model for co-expression pattern Brit. J. Cancer 5.082 Carroll M., Lecoeur C., Goff L., analysis of genes implicated in 87: 537-544 (2002). Gyselman V.G., Young B.D., angiogenesis and tumour cell invasion Lowe D.G., Pepper M.S., in cervical cancer. Shepherd J.H. and Jacobs I.J. 75 Tille J.C. and Pepper M.S. Mesenchymal cells potentiate vascular Exp. Cell Res. 3.557 endothelial growth factor-induced 280: 179-191 (2002). angiogenesis in vitro. 76 Podgrabinska S., Braun P., Molecular characterization of Proc. Natl. Acad. 9.737 Velasco P., Kloos B., Pepper lymphatic endothelial cells. Sci. USA M.S. and Skobe M. 99: 16069-16074 (2002). Podgrabinska S., Braun P., Correction Proc. Natl. Acad. Velasco P., Kloos B., Pepper Sci. USA - 33 -
M.S. and Skobe M. 100: 4970 (2003). 77 Tille J.C., Wang X., Lipson Vascular endothelial growth factor Exp. Cell Res. 3.557 K.E., McMahon G., Ferrara N., (VEGF) receptor-2 signaling mediates 285: 286-298 (2003). Zhu Z., Hicklin D.J., Sleeman VEGF-CΔNΔC- and VEGF-A-induced J.P., Eriksson U., Alitalo K. and angiogenesis in vitro. Pepper M.S. 78 Tille J.C., Morris M.A., Familial predisposition to tufted Clin. Genet. 4.247 Bründler M.A and Pepper M.S. angioma – identification of blood and 63: 393-399 (2003). lymphatic vascular components. 79 Wernert N., Okuducu A.F. and Ets 1 is expressed in capillary blood J. Pathol. 7.585 Pepper M.S. vessels but not in lymphatics. 200: 561-567 (2003). 80 Van Trappen P.O., Steele D., Expression of vascular endothelial J. Pathol. 7.585 Lowe D.G., Baithun S., Beasley growth factor (VEGF)-C and VEGF- 201: 544-554 (2003). N., Thiele W., Weich H., D, and their receptor VEGFR-3, Krishnan J., Shepherd J.H., during different stages of cervical Pepper M.S., Jackson D.G, carcinogenesis. Sleeman J.P. and Jacobs I.J. 81 Nisato R.E., Tille J.C., Jonczyk v3 and v5 integrin antagonists Angiogenesis 3.972 A., Goodman S.L. and Pepper inhibit angiogenesis in vitro. 6: 105-119 (2003). M.S. 82 Zhang H., Vutskits L., Pepper VEGF is a chemoattractant for FGF-2 J. Cell Biol. 10.822 M.S. and Kiss J.Z. stimulated neural progenitors. 163: 1375-1384 (2003). 83 Pepper M.S., Hazel S.J., 8-Prenylnaringenin, a novel J. Cell Physiol. 4.218 Hümpel M. and Schleuning W.- phytoestrogen, inhibits angiogenesis in 199: 98-107 (2004). D. vitro and in vivo. 84 Persaud K., Tille J.C., Liu M., Involvement of the VEGF receptor-3 J. Cell Sci. 5.877 Zhu Z., Jimenez X., Peirera D., in capillary morphogenesis 117: 2745-2756 Miao H.Q., Witte L., Pepper demonstrated with a human anti- (2004). M.S. and Pytowski B. human VEGFR-3 antibody that antagonizes receptor activation by VEGF-C. 85 Aurrand-Lions M., Johnson- Hemangiomas are formed by cells J. Pathol. 7.585
Leger C., Pepper M.S. and expressing high levels of integrin v3 203: 700-709 (2004). Imhof B.A. and lacking acetylated-LDL uptake. 86 Nisato R.E., Harrison J.A., Generation and characterization of Am. J. Pathol. 4.522 Buser R., Orci L., Rinsch C., telomerase-transfected human 165: 11-24 (2004). Montesano R., Dupraz P., lymphatic endothelial cells with an Pepper M.S. extended lifespan. 87 Rubbia-Brandt L., Terris B., Lymphatic vessel density and VEGF-C Clin. Cancer Res. 7.837 Giostra E., Dousset B., Morel P. expression correlate with malignant 10: 6919-6928 and Pepper M.S. behavior in human pancreatic (2004). endocrine tumors. 88 Alizadeh N., Pittet B., Pyke C., Active-site inactivated FVIIa (FVIIai) J. Surg. Res. 2.018 Baetens D., Montandon D., increases survival in a random skin 122: 263-273 (2004). Ezban M. and Pepper M.S. flap model of acute ischemia. 89 Kiriakidis S., Högemeier O., Novel tempeh (fermented soyabean) Brit. J. Nutr. 3.302 Starcke S., Dombrowski F., isoflavones inhibit in vivo 93: 317-323 (2005). Hahne J.C., Pepper M., Jha H.C. angiogenesis in the chicken and Wernert N. chorioallantoic membrane assay. 90 Soulié P., Carrozzino F., Pepper Membrane-type-1 matrix Oncogene 7.357 M.S., Strongin A.Y., Poupon metalloproteinase confers 24:1689-1697 M.-F. and Montesano R. tumorigenicity on non-malignant (2005). epithelial cells. 91 Zanetta L., Corada M., Downregulation of vascular Thromb. 6.094 Lampugnani M., Zanetti A., endothelial-cadherin expression is Haemostasis - 34 -
Breviario F., Moons L., associated with an increase in vascular 93: 1041-1046 Carmeliet P., Pepper M.S., and tumor growth and hemorrhagic (2005). Dejana E. complications. 92 Nisato R.E., Hosseini G., Dissecting the role of matrix Cancer Res. 8.650 Sirrenberg C., Butler G.S., metalloproteinases (MMP) and 65: 9377-9387 Crabbe T., Docherty A.J.P., integrin v3 in angiogenesis in vitro: (2005). Wiesner M., Murphy G., absence of hemopexin C domain Overall C.M., Goodman S.L. bioactivity, but membrane-type 1- and Pepper M.S. MMP and v3 are critical. 93 Brundler M.A., Harrison J.A., Lymphatic vessel density in the J. Clin. Pathol. 2.439 de Saussure B., de Perrot M., neoplastic progression of Barrett 59:191-195 (2006). Pepper M.S. oesophagus to adenocarcinoma. 94 Buser R., Montesano R., Garcia Bovine microvascular endothelial cells J. Cell. Biochem. 3.062 I., Dupraz P. and Pepper M.S. immortalized with human telomerase. 98: 267-286 (2006). 95 Jenny B., Harrison J.A., Baetens Expression and localization of VEGF- J. Pathol. 7.585 D., Tille J.C., Burkhardt K., C and VEGFR-3 in glioblastomas and 209: 34-43 (2006). Mottaz H., Kiss J.Z., Dietrich hemangioblastomas. P.Y., De Tribolet N., Pizzolato G.P., Pepper M.S. 96 Friedrichs N., Hahne J.C., Immunohistochemical quantification Histopathology 2.857 Pepper M.S., Rommerscheidt- of lymph vessels, VEGF-C and VEGF 49: 87-88 (2006). Fuss U., Stelzner F., Buettner R. receptor 3 in human sarcomas. and Wernert N. 97 Mahajan A.L., Tenorio X., Progressive tissue injury in burns is Burns 1.799 Pepper M.S., Baetens D., reduced by rNAPc2. 32: 957-963 (2006). Montandon D., Schlaudraff K.U., Pittet B. 98 Mathe Z., Dupraz P., Rinsch C., Tetracycline-regulated expression of Cell 4.422 Thorens B., Bosco D., Zbinden VEGF-A in beta-cells induces Transplantation: M., Morel P., Berney T. and angiogenesis: improvement of 15: 621-636 (2006). Pepper M.S. engraftment following transplantation. 99 Alizadeh N., Pepper M.S., Persistent ischemia impairs Wound Rep. Reg. 2.757 Modarressi A., Alfo K., myofibroblast development in wound 15: 809-816 (2007). Schlaudraff K., Montandon D., granulation tissue. A new model of Gabbiani G., Bochaton-Piallat delayed wound healing. M.L. and Pittet B. 100 Schlaudraff K.U., Bezzola T., Mixed arterio-venous insufficiency in J. Surg. Res. 2.018 Montandon D., Pepper M.S., random skin flaps in the rat: is the 150: 85-91 (2008). Pittet B. application of medicinal leeches beneficial? 101 Schlaudraff K.U., Pepper M.S., Hypoxic preconditioning increases High Alt. Med. Biol. 2.122 Tkatchouk E.N., Ehrenburg I., skin oxygenation and viability but 9: 76-88 (2008). Alizadeh N., Montandon D., does not alter VEGF expression or Pittet B. vascular density. 102 Pegu A., Qin S., Fallert Junecko Human lymphatic endothelial cells J. Immunol. 5.520 B.A., Nisato R.E., Pepper M.S., express multiple functional TLRs. 180: 3399-3405 Reinhart T.A. (2008). 103 Mabeta P. and Pepper M.S. A comparative study on the anti- Angiogenesis 3.972 angiogenic effects of DNA-damaging 12: 81-90 (2009). and cytoskeletal-disrupting agents. 104 Hammer T., Tritsaris K., IL-20 activates human lymphatic Microvasc. Res. 78: 2.929 Hübschmann M.V., Pepper endothelial cells causing cell 25-32 (2009). M.S., Nisato R.N. and Dissing signalling and tube formation. S. 105 Jordaan D.W., Woodrow C. and Banning private umbilical cord blood S. Afr. J. Hum. Pepper M.S. banks: a human rights analysis. Rights 25: 126-151 - 35 -
(2009).
106 Flister M.J., Wilber A., Hall Inflammation induces Blood 115: 418-429 9.060 K.L, Iwata C., Miyazono K., lymphangiogenesis through (2010). Nisato R., Pepper M.S., Zawieja upregulation of VEGFR-3 mediated by D.C. and Ran S. NF-B and Prox1. 107 Slabbert M.N. and Pepper M.S. “A room of our own?” Legal lacunae Tydskrif vir regarding genomic sovereignty in Hedendaagse South Africa. Romeins-Hollandse Reg (J. Contemporary South African Roman-Dutch Law) 73: 432-450 (2010). 108 Dodgen T.M., Cromarty A.D. Quantitative plasma analysis using J. Separation 2.591 and Pepper M.S. automated online solid-phase Science. extraction with column switching LC- 34: 1102-1110 MS/MS for characterising cytochrome (2011). P450 2D6 and 2C19 metabolism. 109 Pepper M.S. and Slabbert M.N. Is South Africa on the verge of a S. Afr. J. Bioethics medical malpractice litigation storm? Law 4: 29-35 (2011). 110 Slabbert M.N., Maister B., The application of the Consumer Comp. Int. Law J. Botes M. and Pepper M.S. Protection Act in the South African Southern Afr. health care context: concerns and (CILSA). recommendations. 94: 168-203 (2011). 111 Ammar A., Mohammed R.A.A., Lymphatic expression of CLEVER-1 Anal. Cell Pathol. Salmi M., Pepper M., Paish in breast cancer and its relationship 34: 67-78 (2011) E.C., Ellis I.O. and Martin S.G. with lymph node metastasis. 112 Mabeta P. and Pepper M.S. Inhibition of hemangioma Angiogenesis 3.972 development in a syngeneic mouse 15: 131-139 (2012). model correlates with bcl-2 suppression and the inhibition of Akt kinase activity. 113 de Vries J., Slabbert M.N. and Ethical, legal and social issues in the Med. Law J. Pepper M.S. context of the planning stages of the 31:119-152 (2012). Southern African Human Genome Programme. 114 de Vries J. and Pepper M. Genomic sovereignty and the African J. Med. Ethics 1.419 promise: mining the African genome 38: 474-478 (2012). for the benefit of Africa. 115 Meissner-Roloff M., Young Pilot social feasibility study for the Stem Cell Rev. Rep. 4.523 W.M., Rangaka I., Lombaard establishment of a public human 8: 1066-1075 (2012). H., Dhai A., Tsotsi N. and umbilical cord blood stem cell bank in Pepper M.S. South Africa. 116 Alessandrini M., Klose K. and Technology transfer practices at South Innovation: Pepper M.S. African universities and science Management, councils. Policy and Practice 15: 207-216 (2013). 117 Dodgen T.M., Hochfeld W.E., Introduction of the AmpliChip BMC Med. Genet. 2.536 Fickl H., Asfaha S.M., Durandt CYP450 Test to a South African 14:20 (2013). C., Rheeder P., Drögemöller cohort: a platform comparative B.I., Wright G.E.B., Warnich prospective cohort study. L., Labuschagne D. de J., van Schalkwyk A., Gaedigk A. and Pepper M.S. - 36 -
118 Mahomed S., Slabbert M.N. and The legal position of the classification S. Afr. J. Bioethics Pepper M.S. of human tissue in South Africa – can Law tissues be owned? 6: 16-20 (2013). 119 Nielsen S.R., Hammer T., IL-27 inhibits lymphatic endothelial Microcirculation 2.736 Gibson J., Pepper M.S., Nisato cell proliferation by STAT1-regulated 20: 555-564 (2013). R.E., Dissing S. and Tritsaris K. gene expression.
120 Barmania F., Potgieter M. and Mutations in C-C chemokine receptor Int. J. Infect. Dis. 2.357 Pepper M.S. type five (CCR5) in South African 17: e1148–e1153 individuals. (2013). 121 Meissner-Roloff and Pepper Establishing a public umbilical cord Stem Cell Rev. Rep. 4.523 M.S. blood stem cell bank (UCB SCB) for 9: 752–763 (2013). South Africa: an enquiry into public acceptability.
122 Grant C.C., Janse van Rensburg The correlation between the health- S. Afr. Family D.C., Pepper M.S., du Toit P.J., related fitness of healthy participants Practice. Wood P.S., Ker J., Krüger P.E., measured at home opposed to fitness 56: 235-239 (2014). Grobbelaar C.W., Nolte K., measured by sport scientists in a Fletcher L. and Grant T.C. laboratory. 123 Mabeta P. and Pepper M.S. Altered expression of platelet factor 4 Biomedicine & and basic fibroblast growth factor Pharmacotherapy correlates with the inhibition of tumor 69: 186-190 (2015). growth in mice. 124 Mellet J., Alessandrini M., Steel Constituting a public umbilical cord Bone Marrow H.C and Pepper M.S. blood bank in South Africa. Transplantation. In press (2015). 125 Taylor J., Anyango J.O., Biocompatibility and biodegradation Journal of Potgieter M., Kallmeyer K., of protein microparticle and film Biomedical Naidoo V., Pepper M.S and scaffolds made from kafirin (sorghum Materials Taylor J.R.N. prolamin protein) subcutaneously Research: Part A. implanted in rodent models. In press (2015).
Review Articles and Editorials
Total impact factor: 266.52 Number of publications: 53 (12 without IF) Mean impact factor per article: 6.50 (As of June 2014)
No. Authors Title Journal Impact Factor 1 Pepper M.S. Dance - a suitable form of exercise? A S. Afr. Med. J. 1.702 physiological appraisal. 66: 883-888 (1984). 2 Montesano R., Pepper M. Angiogenesis in vitro: morphogenetic News Physiol. Sci. 6.750 and Orci L. and invasive properties of endothelial 5: 75-79 (1990). cells. 3 Pepper M.S. and Proteolytic balance and capillary Cell Diff. Dev. Montesano R. morphogenesis. 32: 319-328 (1990).
4 Vassalli J.-D. and Pepper Tumor biology: membrane proteases in Nature 38.597 M.S. focus. 370: 14-15 (1994). - 37 -
5 Fotsis T., Pepper M., Genistein, a dietary ingested J. Nutr. 4.196 Aldercreutz H., Hase T., isoflavonoid, inhibits cell proliferation 125: 790S-797S Montesano R. and and in vitro angiogenesis. (1995). Schweigerer L. 6 Pepper M.S., Mandriota Angiogenesis regulating cytokines: Curr. Top. 4.860 S.J., Vassalli J.-D., Orci activities and interactions. Microbiol. L. and Montesano R. 213/II: 31-67 (1996). 7 Pepper M.S., Montesano Angiogenesis: a paradigm for balanced Enzyme Protein R., Mandriota S.J., Orci extracellular proteolysis during cell 49: 138-162 (1996). L. and Vassalli J.-D. migration and morphogenesis. 8 Pepper M.S. Positive and negative regulation of Vasc. Med. 1.617 angiogenesis: from cell biology to the 1: 259-266 (1996). clinic. 9 Pepper M.S. Transforming growth factor-beta: Cytokine Growth F. 8.831 vasculogenesis, angiogenesis and vessel R. wall integrity. 8: 21-43(1997). 10 Pepper M.S. Manipulating angiogenesis: from basic Arterioscl. Thromb. 6.338 science to the bedside. Vasc. Biol. 17: 605- 619 (1997). 11 Montesano R., Soriano Induction of epithelial branching J. Cell. Physiol. 4.218 J.V., Pepper M.S. and tubulogenesis in vitro. 173: 152-161 (1997). Orci L. 12 Soriano J.V., Pepper Roles of hepatocyte growth J. Mammary Gland 7.524 M.S., Orci L. and factor/scatter factor and transforming Biol. Neoplasia Montesano R. growth factor-1 in mammary gland 3: 133-150 (1998). ductal morphogenesis. 13 Fotsis T., Pepper M.S., Phytoestrogens and inhibition of Baillieres Clin. Montesano R., Aktas E., angiogenesis. Endocrinol. Metab. Breit S., Schweigerer L., 12: 649-666 (1998). Rasku S., Wahala K. and Adlercreutz H. 14 Mandriota S.J. and Lymphangiogenèse et activité J. Soc. Biol. Pepper M.S. biologique du facteur de croissance 193: 159-163 (1999). vasculaire endothéliale-C. 15 Pepper M.S. Angiogenèse et morphogenèse de l‟arbre Médecine Sciences vasculaire: de la biologie cellulaire à la 12: 1378-1386 clinique. (2000).
16 Pepper M.S. Lymphangiogenesis and tumor Lymphology 1.190 metastasis: more questions than answers. 33: 144-147 (2000). 17 Pepper M.S. Lymphangiogenesis and tumor Clin. Cancer Res. 7.837 metastasis: myth or reality? 7: 462-468 (2001). 18 Van Trappen P.O. and Lymphangiogenesis and lymphatic Gynecol. Oncol. 3.929 Pepper M.S. microdissemination. 82: 1-3 (2001). 19 Pepper M.S. Extracellular proteolysis and Thromb. 6.094 angiogenesis. Haemostasis 86: 346-355 (2001). 20 Pepper M.S. Role of the matrix metalloproteinase and Arterioscl. Thromb. 6.338 plasminogen activator-plasmin systems Vasc. Biol. in angiogenesis. 21: 1104-1117 (2001). 21 Van Trappen P.O. and Lymphatic dissemination of tumor cells Lancet Oncol. 25.117 Pepper M.S. and the formation of micrometastases. 3: 44-52 (2002). 22 Orci L. and Pepper M.S. Microscopy: an art? Nat. Rev. Mol. Cell 37.162 Biol. 3: 133-137 (2002). - 38 -
23 Nisato R.E., Tille J.-C. Lymphangiogenesis and tumor Thromb. 6.094 and Pepper M.S. metastasis. Haemostasis 90: 591-597 (2003). 24 Pepper M.S. and Skobe Lymphatic endothelium: morphological, J. Cell Biol. 10.822 M. molecular and functional properties. 163: 209-213 (2003). 25 Pepper M.S., Tille J.-C., Lymphangiogenesis and tumor Cell Tissue Res. 3.677 Nisato R. and Skobe M. metastasis. 314: 167-177 (2003). 26 Tille J.-C. and Pepper Hereditary vascular anomalies: new Arterioscl. Thromb. 6.338 M.S. insights into their pathogenesis. Vasc. Biol. 24: 1578-1590 (2004). 27 Pathak A.P., Bhujwalla Visualizing function in the tumor- Lymphatic Res. 2.333 Z.M. and Pepper M.S. associated lymphatic system. Biol. 2: 165-172 (2004). 28 Pepper M.S. Polymorphisms in the endothelial nitric J. Neurosurg. 3.148 oxide synthase gene and the tendency 102: 433 (2005). for aneurysm rupture. 29 Van Trappen P.O. and Lymphangiogenesis in human Angiogenesis 3.972 Pepper M.S. gynaecological cancers. 8: 137-145 (2005). 30 van der Merwe M.T. and Obesity in South Africa. Obesity Rev. 7: 315- 6.870 Pepper M.S. 322 (2006). 31 Van der Auwera I., Cao First international consensus on the Brit. J. Cancer 5.082 Y., Tille J.C., Pepper methodology of lymphangiogenesis 95: 1621-1625 M.S., Detmar M., Jackson quantification in solid human tumours. (2006). D.G., Fox S.B., Harris A.L., Dirix L.Y., Vermeulen P.B. 32 Pepper M.S. and van der The genetics of obesity. S. Afr. Cardiol. Merwe M.T. Stroke J. Spring: 48,50 (2007). 33 Pathak A.P., Hochfeld Circulating and imaging markers for Angiogenesis 3.972 W.E., Goodman S.L. and angiogenesis. 11: 321-325 (2008). Pepper M.S. 34 Pepper M.S. The stem cell regulatory environment in S. Afr. Med. J. 1.702 South Africa: cause for concern. 99: 505-507 (2009). 35 Logan M.G. and Pepper The genetics of obesity: the role of the J. Endocrinol. M.S. melanocortin 4 receptor. Metab. Diabetes S. Afr. 15: 45-47 (2010). 36 Pepper M.S. Cell-based therapies: navigating troubled S. Afr. Med. J. 1.702 waters. 100: 34-35 (2010). 37 Pepper M.S. The human genome and molecular S. Afr. Med. J. 1.702 medicine: promises and pitfalls. 100:722-724 (2010). 38 Mabeta P. and Pepper Hemangiomas: current therapeutic Int. J. Dev. Biol. 2.614 M.S. strategies. 55: 431-437 (2011). 39 Slabbert M.N. and Pepper No-fault liability of health care S. Afr. Med. J. 1.702 M.S. providers in therms of the Consumer 101: 800-801 (2011). Protection Act. 40 Pepper M.S. Launch of the Southern African Human S. Afr. Med. J. 1.702 Genome Programme. 101: 287-288 (2011) 41 Warnich L., Drögemöller Pharmacogenomic research in South Curr. B.I., Pepper M.S., Africa: lessons learned and future Pharmacogenomics Dandara C and Wright opportunities in the rainbow nation. Personalized Med. G.E.B. 9: 191-207 (2011). 42 Myburgh R., Hochfeld Cardiovascular pharmacogenetics. Pharmacol. 7.793 W.E., Dodgen T.M., Ker Therapeut. - 39 -
J. and Pepper M.S. 133: 280-290 (2012). 43 Meissner-Roloff M. and Stem cell research engenders S. Afr. J. Sci. 0.835 Pepper M.S. interdisciplinary collaboration in 108: 5-6 (2012). science, ethics and religion. 44 Pepper M.S. Partial relief from the regulatory vacuum S. Afr. Med. J. 1.702 involving human tissues through 102: 736-737 (2012). enactment of Chapter 8 of the National Health Act and regulations thereto. 45 Pepper M.S. Enactment of Chapter 8 of the National S. Afr. J. Bioethics Health Act and regulations thereto. Law. 5: 60 (2012). 46 Potgieter M., Pretorius E. Primary and secondary coenzyme Q10 J. Nutrition 4.196 and Pepper M.S. deficiency: the role of therapeutic 71: 180-188 (2013). supplementation. 47 Jackson C. and Pepper Opportunities and barriers to Stem Cell Res. 3.652 M.S. establishing a cell therapy programme in Ther. South Africa. 4 : 54 (2013). 48 Barash C.I. and Pepper Editorial: Special issue Appl. Translational M.S. pharmacogenomics & personalized Genomics. medicine. 2: 1-2 (2013). 49 Barmania F. and Pepper C-C chemokine receptor-5 (CCR5): an Appl. Translational M.S. emerging target for the control of HIV Genomics. infection. 2: 3-16 (2013). 50 Meissner-Roloff M. and Curbing stem cell tourism in South Appl. Translational Pepper M.S. Africa. Genomics. 2: 22-27 (2013). 51 Alessandrini M., Asfaha CYP450 pharmacogenetics in African Drug Metab. Rev. 5.538 S.M., Dodgen T.M., populations. 45: 253-75 (2013). Warnich L. and Pepper M.S. 52 Ali A.T., Hochfeld W.E. Adipocyte and adipogenesis. Eur. J. Cell Biol. 3.213 Myburgh R. and Pepper 92:229-236 (2013). M.S. 53 Alessandrini M. and Priority pharmacogenetics for the Pharmacogenomics 3.857 Pepper M.S. African continent: focus on cytochrome 15:385-400 (2014) P450. 54 Čolić A., Alessandrini M. Pharmacogenetics of CYP2B6, Drug Metabolism and Pepper M.S. CYP2A6, and UGT2B7 in HIV Rev. treatment in African populations: focus In press (2015) on efavirenz and nevirapine. 55 Kallmeyer K. and Pepper Homing properties of mesenchymal Expert Opinion on M.S. stromal cells. Biological Therapy. In press (2015) 56 Atashi F., Modarressi- The role of reactive oxygen species in Stem Cells and Ghavami A. and Pepper mesenchymal stem cell adipogenic and Development. M.S. osteogenic differentiation : a review. In Press (2015)
Chapters in Books
No. Authors Chapter Title Book Ref 1 Montesano R., The control of angiogenesis: endothelial In Pathophysiology of pulmonary Pepper M.S., cell-matrix interactions and extracellular cells. Endothelial and mucus - 40 -
Vassalli J.-D. and proteolysis. In Pathophysiology of producing cells. A. Junod, D. Olivieri Orci L. pulmonary cells. Endothelial and mucus and E. Pozzi, Eds. Masson Italia producing cells. Periodici (Milan): 1-17, 1991. 2 Montesano R., Modulation of angiogenesis in vitro. In Angiogenesis: key principles, Pepper M.S., science, technology, medicine. P.B. Vassalli J.-D. and Weisz, R. Langer and R. Steiner, Eds. Orci L. Birkhäuser Verlag (Basel): 129-136, 1992. 3 Pepper M.S., Proteolytic balance and capillary In Angiogenesis: key principles, Vassalli J.-D., Orci morphogenesis in vitro. science, technology, medicine. P.B. L. and Montesano R. Weisz, R. Langer and R. Steiner, Eds. Birkhäuser Verlag (Basel): 137-145, 1992. 4 Montesano R., The role of growth factors and In Frontiers in endocrinology. Vassalli J.-D., Orci extracellular matrix in angiogenesis and Volume 6: Developmental L. and Pepper M.S. epithelial morphogenesis. endocrinology. P.C. Sizonenko, M.L. Aubert and J.-D. Vassalli, Eds. Ares- Serono Symposia Publications (Rome): 43-66, 1994. 5 Pepper M.S., Angiogenesis in vitro: cytokine In Angiogenesis: molecular biology, Vassalli J.-D., Orci interactions and balanced extracellular clinical aspects. M.E. Maragoudakis, L. and Montesano R. proteolysis. P.M. Gullino and P.I. Lelkes, eds. Plenum Press (New York): 149-170, 1994. 6 Fotsis T., Pepper Inhibitors of angiogenesis in human In Molecular, cellular and clinical M.S., Aktas E., urine. aspects of angiogenesis. M.E. Joussen A., Kruse Maragoudakis, Ed. Plenum Press F., Adlercreutz H., (New York): 213-227, 1996. Wähälä K., Hase T., Montesano R. and Schweigerer L. 7 Pepper M.S., Endothelial cells transformed by In Tumour angiogenesis. R. Bicknell, Tacchini-Cottier F., polyomavirus middle T oncogene: a C.E. Lewis and N. Ferrara, Eds. Sabapathy K., model for hemangiomas and other Oxford University Press (Oxford): Montesano R. and vascular tumours. 309-331, 1997. Wagner E.F. 8 Montesano R. and Three-dimensional in vitro assay of In: Vascular morphogenesis: in vivo, Pepper M.S. endothelial cell invasion and capillary in vitro, in mente. C.D. Little, V. tube morphogenesis. Mironov and H. Sage, Eds. Birkhäuser Boston (Cambridge, MA): 79-110, 1998. 9 Pepper M.S. and Eléments d‟angiogenèse cutanée. In: Dermatologie et maladies Saurat J.-H. sexuellement transmissibles, 3ème édition. J.-H. Saurat, E. Grosshans, P. Laugier, J.-M. Lachapelle, Eds. Masson (Paris): 626-627, 1999. 10 Pepper M.S. Angiogenesis and vascular In: Hemostasis and Thrombosis: morphogenesis. Basic Principles and Clinical Practice. R.W. Colman, J. Hirsh, V.J. Marder, A.W. Clowes and J.N. George, Eds. Lippincott-Raven Publishers (Philadelphia): 771-779, 2001. 11 Montesano R. and Capillary morphogenesis in vitro: In: Tumor angiogenesis and Pepper M.S.: cytokine interactions and balanced microcirculation. E.E. Voest and P.A. proteolysis. D'Amore, Eds. Marcel Dekker Inc. - 41 -
(New York): 111-141, 2001. 12 Iruela-Arispe M.L., Vascular morphogenesis the mammary In: Vascular Morphogenesis in the Ortega M.A., gland – introduction and overview. Female Reproductive System. Oikemus S. and Cardiovascular Molecular Pepper M.S. Morphogenesis Series. H.G. Augustin, M.-L. Iruela-Arispe, P.A.W. Rogers and S.K. Smith, Eds. Birkhäuser (Boston): 3-24, 2001. 13 Saaristo A., Growth factor regulation of In: Vascular Morphogenesis in the Karkkainen M.J., physiological angiogenesis in the Female Reproductive System. Alitalo K., mammary gland. Cardiovascular Molecular Montesano R., Morphogenesis Series. H.G. Iruela-Arispe M.-L. Augustin, M.-L. Iruela-Arispe, and Pepper M.S. P.A.W. Rogers and S.K. Smith, Eds. Birkhäuser (Boston): 25-40, 2001. 14 Pepper M.S., Angiogenesis-regulating cytokines. In: The New Angiotherapy. T.-P. Fan Mandriota S.J. and and E.C. Kohn, Eds. Humana Press Montesano R.: Inc. (Totowa, NJ): 7-40, 2002. 15 Pepper M.S. Role of the plasminogen activator- In: Plasminogen: structure, activation plasmin system in angiogenesis. and regulation. D.M. Waisman, Ed. Kluwer Academic/Plenum Publishers (New York): 269-290, 2003. 16 Tille J.-C., Nisato R. Lymphangiogenesis and tumour John Wiley and Sons Ltd (Chichister, and Pepper M.S. metastasis. Novartis Foundation UK): 112-136, 2004. Symposium 256: Cancer and Inflammation. 17 Pepper M.S. and Eléments d‟angiogenèse cutanée. In: Dermatologie et infections Saurat J.-H. sexuellement transmissibles, 4ème édition. J.-H. Saurat, E. Grosshans, P. Laugier, J.-M. Lachapelle, Eds. Masson (Paris): 694-695, 2004. 18 van der Merwe M.T. Energy conservation during evolution: In: Voyages in Science. Essays by and Pepper M.S. the impact on obesity, a modern South African anatomists in honour epidemic. of Philip V. Tobias‟ 80th birthday. G. Strkalj, N. Pather and B. Kramer, Eds. Content Solutions (Pretoria): 141-157, 2005. 19 Pepper M.S. The lymphatic system. In: Encyclopedia of the Microvasculature. D. Shepro, Ed. Elsevier Inc. (San Diego): 523-527, 2005. 20 Harrison J.A., Buser Angiogenesis, lymphangiogenesis and In: Hemostasis and Thrombosis: R. and Pepper M.S. vascular morphogenesis. Basic Principles and Clinical Practice. 5th edition. R.W. Colman, V.J. Marder, A.W. Clowes, J.N. George and S.Z. Goldhaber Eds. Lippincott Williams and Williams (Philadelphia): 679-689, 2005. 21 Pepper M.S. and The lymphatic vascular system in In: Selected topics in cancer Lolas G. lymphangiogenesis, invasion and modeling: genesis, evolution, immune metastasis: a mathematical approach. competition, and therapy. N. Bellomo, M. Chaplain, and E. De Angelis Eds. Series: Modelling and Simulation in Science, Engineering and Technology. Birkhauser (Boston, MA). 255-276, 2008. - 42 -
22 Durandt C., Asfaha Pharmacogenetics. In: Molecular Medicine for S.M. and Pepper Clinicians. B. Mendelow, M. M.S. Ramsay, N. Chetty and W. Stevens Eds. Wits University Press (Johannesburg). 433-437, 2009. 23 Nisato R.E., Buser Lymphatic endothelial cells: In: Methods in Molecular Medicine R. and Pepper M.S. establishment of primaries and 467: Angiogenesis Protocols 2nd characterization of established lines. edition. S. Martin and C. Murray Eds. Humana Press Inc. (New York, NY). 113-126, 2009. 24 Pepper M.S. and Eléments d‟angiogenèse cutanée. In: Dermatologie et infections Saurat J.-H. sexuellement transmissibles, 5ème édition. J.-H. Saurat, J.-M. Lachapelle, D. Lipsker, L. Thomas, Eds. Masson (Paris): 698-699, 2009. 25 Hochfeld W.E, Pharmacogenetics and In: Genomics and Health in the Asfaha S.M., pharmacogenomics in the developing Developing World. D. Kumar Ed. Alessandrini M., world. Oxford University Press (New York): Dodgen T.M., 168-191, 2011. Myburgh M., Eloff A. and Pepper M.S.
Patents
Patent full title: Stimulation, modulation and/or inhibition of endothelial proteolytic activity and/or angiogenic activity Patent number: WO 1999008522 A1 This is a utility patent Description of patent: Vascular endothelial growth factor-B (VEGF-B) and vascular endothelial growth factor- C (VEGF-C) are angiogenic polypeptides. It has been shown that VEGF-B and -C are angiogenic in vitro especially in combination with bFGF. VEGF-C also increases plasminogen activator (PA) activity in bovine endothelial cell lines and this is accompanied by a concomitant increase in PA inhibitor-1. Addition of alpha-2- antiplasmin to bovine endothelial cells co-treated with bFGF and VEGF-C partially inhibits collagen gel invasion. Patent Assignee: Ludwig Inst Cancer Res; Univ Helsinki Licensing; Univ Geneva Inventors: Pepper M.S., Alitalo K., Eriksson U. Web address: http://www.google.com/patents/WO1999008522A1?cl=en Own contribution: Responsible for the key findings, namely synergism between antiogenic cytokines, and stimulation of angiogenic and proteolytic activity by these cytokines in vitro
Patent full title: Methods and compositions for directing migration of neural progenitor cells Patent number: US 2008/0118480 A1 This is a utility patent Description of patent: Method for modulating the migration of neural progenitor cells in a mammal by exposing the cells to a VEGFR-2 ligand and FGF-2. Methods of treating neurological disorders by exposing the mammal to a VEGFR-2 ligand in the presence of FGF-2 are also provided. A composition including a biocompatible matrix associated with FGF-2 is also provided. Patent assignee: Imclone Systems Incorporated New York NY, USA Inventors: Zhang H., Vutsikas L., Pepper M.S., Kiss J.Z. Web address: http://www.google.com/patents/US20080118480 Own contribution: Invloved in the conceptualization and execution of the experiments leading to the key findings
- 43 - Patent full title: Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids Patent number: WO 1997045143 A1 This is a utility patent Description of patent: This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on the role of their signaling pathway in endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagged protein, as well as a substantially purified nucleic acid molecule or segment thereof encoding Jagged protein, or a functionally equivalent derivative, or allelic or species variant thereof. Patent assignee: Thomas Maciag, Roberto Montesano, Nat American Red Cross; Michael S. Pepper, Univ Geneve Michael K K Wong, Ann B Zimrin Inventors: Maciag T., Montesano R., Pepper M.S., Wong M.K.K., Zimrin A.B. Web address: http://www.google.com/patents/WO1997045143A1?cl=en Own contribution: Invloved in the conceptualization and execution of the experiments leading to the key findings
Patent full title: Transgenic cell selection Patent number: PCT PATENT: PCT/US2014/019308 (based on US Provisional Application 61/771,331) This is a utility patent Description of patent: The invention relates generally to the field of molecular biology and medicine. More particularly, it concerns methods for production and selection of transgenic cells and vectors for the production of such cells. Inventors: Krause K.H., Suter D., Salmon P., Myburgh R., Pepper M.S. Web address: application not published yet; anticipated publication date: Jan 2015 Own contribution: Co-initiator of the HIV gene therapy project.
Technical/policy reports
1. Pepper M.S., Ramburan V.P. and Lamprecht S. Report on the BioSA / COFISA Intervention aimed at facilitating South African and Finnish business-to-business collaboration in the Biotechnology and Life Science sectors. May 2008. (56 pages)
2. Alessandrini M., Barnett J., Klose K., Pepper M.S. and van der Bijl P.Understanding Technology Transfer at higher education institutes (HEIs): A South African study. World Bank Institute. June 2010. (120 pages)
3. SAHGP Core Group (Bardien S., Christoffels A., Mphahlele J., Pepper M.S., Ramesar R., Ramsay M., Rees J., Soodyall H., Venter P. and Warnich L), Napier H. and SAHGP writing groups. Southern African Human Genome Programme. Report to the Dept. of Science and Technology, July 2011. (87 pages)
Position statements
4. National Biotechnology Advisory Committee (NBAC). Position statement on Stem Cell Regulations in South Africa. 2008. (Authored by Pepper M.S.)
5. National Biotechnology Advisory Committee (NBAC). Position statement on Genomic Sovereignty in South Africa. 2011. (Authored by Pepper M.S. and Slabbert M.N.)
6. South African Society of Obstetrics and Gynaecology (SASOG). Position statement on umbilical cord blood banking. Soma-Pillay P. and Pepper M.S. 17 March 2014. http://www.sasog.co.za/images/Umbilical_cord_blood_banking_March2014.pdf
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Other Publications
1. Pepper M.S.: An approach to the injured dancer. Arabesque 21: pages 11,13,41, 1983.
2. Pepper M.S.: Understanding the injured dancer. S. Afr. J. Sports Med. 24: 9-13, 1984.
3. Kern P., Calza A.-M., Pittet-Cuenod B., Pepper M.S., Benador D., Lecoultre C., Rüfenacht D. and Bounameaux H.: Hémangiomes et malformations vasculaires: casuistique d'une consultation multidisciplinaire. Médecine et Hygiène 55: 118-123, 1997.
4. Hansson G., Carmeliet P. and Pepper M.: Tribute to Werner Risau: December 18, 1953-December 13, 1998. Arterioscl. Thromb. Vasc. Biol. 19: 829, 1999.
5. Pepper M.S. Lymphangiogenesis and tumor metastasis. Swiss Cancer Bulletin 21: 122-124, 2001.
6. Pepper M.S. Literature Watch – Summary and perspectives. Lymphatic Res. Biol. 1: 245-246, 2003.
7. Molecular and Metabolic Medicine Update newsletter. http://www.ampath.co.za/news.htm
Year Vol No Author Title 2006 2 3 Pepper Stem cell therapy 2 4 van der Merwe and Pepper The genetics of obesity 2 4 Pepper and Naude Blood conservation in South Africa 2 5 Pepper and Durandt Pharmacogenetics 2007 3 2 Naude, Watermeyer and Pepper The transfusion trigger 3 2 Pepper Controversial issues in the stem cell arena 3 3 Pepper and Jordaan Cell-based therapy in South Africa 3 4 Pepper, Gould and Crookes Therapeutic plasma exchange 3 4 Pepper A model for the co-existence of public and private stem cell banks 2008 4 1 Pepper Pharmacogenetics – where are we today? 4 2 Pepper Omega fatty acids -3, -6 and -9. Unraveling the mystery 4 3 Marrs, Pepper Peripheral blood stem cells for bone marrow transplantation 4 4 Pepper Blood conservation 4 5 Pepper, Krause, Stoltz, Sorce Rendering the immune system resistant to HIV – a potential therapeutic strategy? 4 5 Pepper Induced pluripotent stem cells 4 6 Pepper, Pathak A need for novel surrogate markers of angiogenesis 2009 5 2 Pepper The stem cell regulatory environment in South Africa
8. Report: Bioethics Forum on Stem Cell Banking, held at the Innovation Hub, Pretoria, on 15 June 2007. Compiled by: Dominique Schaub, Stephen Marrs, Doretha Thompson, Michael Pepper, Donrich Jordaan. 23 July 2007.
9. CIPS e-briefs. July / August 2007. www.policystudies.up.ac.za Cell-based therapy and the biotech sector in South Africa by Dr David Keetch, Prof Michael Pepper and Prof Jocelyn Webster. A model for the co-existence of public and private stem cell banks by Prof Michael Pepper. Banning private umbilical cord blood banks - a human rights analysis by Adv Donrich Jordaan, Prof Michael Pepper, Adv Christopher Woodrow and Adv Naude de Wet.
- 45 - 10. Report: The Human Tissue Regulatory Environment, held at the Innovation Hub, Pretoria, on 27 May 2009. Compiled by: Michael Pepper. July 2009.
11. Pepper M.S. Regaining perspective on stem cells. S. Afr. Family Practice 52: 164, 2010.
12. Pepper M.S. The healing power of stem cells: why we need rules. S. Afr. Family Practice 52: 365, 2010.
13. Article series in Rolling Inspiration: Pepper. M.S. Stem cell, hard sell (September/October 2009) Pepper. M.S. Regaining perspective on stem cells (January/February 2010) Pepper. M.S. The healing power of stem cells: why we need rules (March/April 2010) Pepper. M.S. We are what we eat (July/August 2010) Pepper. M.S. The importance of keeping accurate records (September/October 2010) Potgieter M. and Pepper M.S. Stem cell therapy: 8 things to consider at decision making crunch time (January/February 2011) Potgieter M. and Pepper M.S. Stem cell therapy for neuromuscular disorders (September/October 2011).
14. Article series in the Muscular Dystrophy Foundation Magazine: Pepper. M.S. Stem cell, hard sell (Vol 32, pages 18-19, August, 2010) Pepper. M.S. Regaining perspective on stem cells (Vol. 33, pages 20-21, December 2010) Pepper. M.S. The healing power of stem cells: why we need rules (Vol. 34, pages 28-29, April 2011) Potgieter M. and Pepper M.S. Stem cell therapy for neuromuscular disorders (Vol. 35, pages 26-27, August 2011).
Web-based programme on stem cells http://www.in3sixty.com/education/20110110_PUB/internet/lowres/pub_intro.html http://www.in3sixty.com/education/20110110_PUB/internet/lowres/pub_stemcells_lab1.htm
Interactions with the Media
Entity Date Title Comment Printed and e-media IOL Lifestyle 2014, 17 February Being gay is no By: Lali van Zuydam conscious decision - expert Pretoria News 2014, 12 February Being gay is no By: Lali van Zuydam conscious decision, says expert Business Day 2014, 14 January Proposed R2bn fund By: Tamar Kahn aims to boost bio-economy Mail and Guardian 2013, 18 October Baby, make those By: Sarah Wild genes talk Mail and Guardian 2013, 11 October SA lights a torch in the By: Sarah Wild genomic revolution Business Day 2013, 06 June Researchers seek By: Tamar Kahn clarity on human tissue rights Sunday Times 2013, 19 May Mapping the Unique By: Bobby Jordan Genes of Southern - 46 -
Africa Mail and Guardian 2013, 17 May Now the beauty of By: Sarah Wild stem cells is only skin deep Beeld 2013, 07 March Stamselbehandeling “is By: Antoinette Pienaar die risiko werd” Izindaba, South 2013, January; 103(1): „Pioneer‟ Paarl neuro By: Chris Bateman African Medical 8-9 sets alarm bells ringing Journal Beeld 2012, 28 December Etiek van Stamselle By: Antoinette Pienaar Beeld 2012, 28 November Stamselle: etiese By: Elzabé Brits komitee moes kyk Die Burger 2012, 28 November Etiese komitee „is nie By: Elzabé Brits betrek‟ Die Burger 2012, 27 November Kenners besorgd oor By: Elzabé Brits behandeling Beeld 2012, 26 November Geen bewys dat dit By: Elzabé Brits werk The Times 2012, 26 October Unborn kids „hold key By: Katharine Child to life‟ Sunday Times 2012, 22 July Doctors are „sick and By: Bobby Jordan tired‟ City Press 2012, 8 July Doctors lose patience By: Eugene Botha as suits spike Rapport 2012, 8 July Hof toe met jou, By: Eugene Botha dokter ! Business Day 2012, 13 January Diverse SA must tap By: Sarah Wild stem cells locally Die Burger 2011, 19 September Stamselle van By: Elsabe Brits naelstringe nou in SA bewaar Business Day 2011, 19 September Venture lifts hope for By: Sarah Wild stem cell progress The Centurion 2011, September The next major wave of commercial activity – Bio-entrepreneurship Business LIVE 2011, 15 September Stem cell storage By: Nashira Davids divides Medical Chronicle 2011, June SA human genome project will benefit local society Biotechnology – Bio-entrepreneurs, a Executive Education new breed in business Business Day 2010, 7 December Research into genetic By: Tamar Kahn variation should help disease prevention Medical Chronicle 2010, October Doing good work against great odds: the challenges faced in stem cell transplants Medical Chronicle 2010, August Bloodless medicine: techniques used to reduce the use of blood and its components The Mercury 2010, 1 June Clarity on stem cells By: Omeshnie Naidoo - 47 -
Business Day 2010, 18 February Tutu gives his genes to By: Tamar Kahn science The Mercury 2009, November Beware of bogus stem By: Omeshnie Naidoo cell therapies: expert warns Medical Chronicle 2009, November Public stem cell bank to move SA into the future of medical research Health 24 2009, 23 September Stem cell research: By: Carine Visagie where it is at Health 24 2009, 11 August Stem cells – hope or hype Financial Mail 2009, 7 August Past cell-by date By: Razina Munshi Weekend Argus 2009, 24 May Acute need for public By: Melanie Peters stem cell bank in SA FIT Pregnancy 2009, February/March Mom‟s the word – By: Lisa Morris 33-34 Where to we come from? Medical Chronicle 2008, July Bloodless programmes address global blood shortage Vrouekeur 2008, 28 March Boustene van „n nuwe By: Tanya de Vente lewe Pretoria News 2007, 20 September Scientist strive to stop By: Di Caelers pending clampdown on stem cell research Mail & Guardian – 2007, 14 September Netcare makes Online investment in stem cell development The Citizen 2007, 13 September Call for support of blood conservation projects Mail & Gaurdian – 2007, 13 September Call to support blood- Online conservation projects Netcare – Media 2007, 12 September Netcare calls on By: Martina Nicholson Release healthcare professionals and SA public to support blood conservation Rekord Oos/East 2007; 30 March Stem cells can now be By: Petro van (Local Paper) stored for later use Rensburg The Argus 2007, September New law will kill stem By: Di Caelers cell industry – experts Die Burger 2007, September Kenner maak sterk By: Elsabe Brits kapsie oor stamselwet Medical Chronicle 2006, October Blood conservation in South Africa Rapport 2006, 3 September „Ek sal alles probeer‟ – By: Marenet Jordaan Stemsel-terapie bring hoop, al sê medici wát Netcare – Media 2006, 14 August Cutting edge institute By: Martina Nicholson Release launched for cellular and molecular medicine - 48 -
Rapport 2006, 13 Augustus Regering moet By: Marenet Jordaan ongesonde kos belas, sê medikus Medical Chronicle 2006, 8 August Umbilical cord blood stem cell therapy harmed by misinformation Mail & Guardian 2006, 4 August Soft sell on stem cells By: Belinda Beresford Insurance gateway – 2006, 20 July Netcare makes Online substantial investment in stem cell development Business iafrica – 2006, 19 July Netcare invests in stem Online cells Medical Chronicle 2006, July Stem cell storage: Insurance against future disease Financial Mail 2006, 5 May The ultimate wash By: Claire Bisseker cycle Netcells – Netcare 2006, May Umbilical cord blood By: Kim Long stem cell storage Netcare – Media 2006, 4 April Netcare‟s blood By: Martina Nicholson Release conservation institute to address dire blood shortage in SA Rapport 2006, 5 February Etiekraad gee groen lig By: Elise-Marie vir harttegniek Tancred South African Medical 2005, January Pharmacogenetics By: Chris Bateman Journal offers hope Financial Mail 2004, 17 December Genes can reduce costs By: Peter Honey Financial Mail 2004, 1 July Race for a Cure By: Jacqui Pile The Scientist 17: 33-34 2003 Cancer‟s other conduit By: Scientist staff (Steve Bunk) Méditorial 2000, 23 October Sur les pas de…. CAP Today 2000, May Cytokines‟ steady By: Karin Titus march to labs Reuters Health 2000, 21 January High plasma level of By: Pam Harrison angiogenic cytokines may help in diagnosis of cancer L‟illustré 41: 66-67 1999, 13 October Demain le pontage sera biologique Bio World 1997, 4 June Finnish researcher By: Sharon Kingman International uncover mechanisms that cause growth of endothelial cells – Lymph Le Temps 1998, 12 May Vaincre le cancer, c‟est By: Anne Crisinel lui couper les vivres GHI 1994, 24 March Cancer: nouvelle piste á Genéve Le Nouveau Quotidien 1994, 18 March Asphyzier et affamer By: Anne Crisinel les tumeurs. Voie prometteuse de reserche sur le cancer - 49 -
Symptômes 1994, p22 Nouvelle substance New in Physical 1990, December; Vol New capillaries make Science 5, 272-273 their way by tightly regulated extracellular proteolysis SAMEDI Litteraire 1990, 10 November Bienfaits et méfaits de l‟angiogenése Television SABC 3 2014, 19 October Stem cells Interviewer: Lindile Mpanza SABC 3 2014, 04 August Stem cells Interviewer: Sipho Stuurman TVJ (TV Jamaica): 2013, 21 November Stem cells Smile Jamaica Kyknet: Nege maande 2013, 8 August Stem cells Dagbreek (eNews) 2013, 19 March Stem cells eTV (eNews) 2012, 13 July Medical Malpractice Litigation SABC 2009, 10 July Current Affairs Summit TV 2009, 13 February Stem cell problems Presenter: Jane van Renen SABC2 2008, 22 November Human interest issues, Presenter: Nastassja Weekend Live the arts, lifestyle and Tait entertainment Netcare TV: Matters 2008, 5 February Therapeutic Medical Applications of Stem Cells Netcare TV: Matters 2007, 6 November Blood conservation Medical Netcare TV: Matters 2007, 7 August Anaemia (Chairperson) Medical Netcare TV: Matters 2007, 4 July Hemochromatosis and (Chairperson) Medical Genetic Disorders Netcare TV: Matters 2007; 2 May Obesity Medical SABC3 2007, 5 March Stem cells eTV – Great 2007, 20 February Stem cell shortage Expectations Emission Pulsations 2002 Le sein dans tous ses TV (Léman Bleue) etats Radio CII Radio 2014, 30 August Stem Cells SAFm 2014, 05 August Stem Cells HealthMatters on 2014, 22 July Stem Cells Interview with Karen SAFm Key Smile94 FM 2014, 15 July Stem cells Interview with Bobby Brown Jamaican Nationwide 2013, 21 November Stem cells Radio: This Morning Show Tuks FM 2013, 3 & 5 August Stem cells: the hype and the hope Radio Junto 2013, 28 May Stem cell research and Interview with - 50 -
therapy Zwelibanzi Sisilana Radio Sonder Grense 2012, 22 November Treatment of spinal Interview with Metzi Monitor (news cord injuries using van der Merwe actuality program) olfactory ensheathing cells SAFM (repeated) as 2012, 1 November Stem cells well as the Swazi and Ndebele stations Radio Sonder Grense 2012, 25 October Treatment of Interview with Hanri Monitor (news mitochondrial Wondergrem actuality program) disorders using (pro)nuclear transfer Talk Radio 702 and 2012, 06 September Human Genome Interview with Stephen 567 Cape Talk Grootes Talk Radio 702 and 2012, 12 July Medical Malpractice Interview with Redi 567 Cape Talk Litigation Thabi Talk Radio 702 and 2012, 09 July Medical Malpractice Interview with Bruce 567 Cape Talk Litigation Whitfield The Money Show SAfm radio 2011, 03 May Stem Cells Interview with Karen Key SAfm radio 2009, 17 September Interview with Science Matters Christina Scott East Coast Radio 2006, 11 August Genetics of obesity Midrand Community 2006, 24 May Stem Cells Radio Radio Sonder Grense 2005, 24 May Beta sel groep Interviewer Marisa de Monitor (news oorplantings vir Klerk actuality program) Diabetes 1: bekostigbaar?
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CONFERENCES, LECTURES AND SEMINARS (BY INVITATION)
1987 Sept. EMBO workshop on Extracellular Matrix and Cell Differentiation. Santa Margherita Ligure, Genoa (Italy). Endothelial cell migration and extracellular proteolysis.
1990 Aug. 13th Sigrid Jusélius Symposium on Cell-Matrix Contacts and Pericellular Proteolysis. Helsinki (Finland). Proteolytic balance and capillary morphogenesis.
1991 Jan. Swiss Institute for Experimental Cancer Research. Epalinges (Switzerland). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
1991 Jan. Jenkinson Lecturer, Department of Zoology and Sir William Dunn School of Pathology, Oxford University. Oxford (UK). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
1991 March International Symposium on Angiogenesis. St. Gallen (Switzerland). Proteolytic balance and capillary morphogenesis in vitro.
1991 June XIème Forum de Cancerologie de la Société Française du Cancer et de la Fédération National des Centres de Lutte Contre le Cancer. Paris (France). Plenary lecture: Angiogenèse et Cancer.
1991 Sept. International Society for Heart Research. 12th European Section Meeting. Leuven (Belgium). Proteolytic balance and capillary morphogenesis in vitro.
1991 Oct. 2nd Symposium on Growth, Differentiation and Pathology of Vascular Endothelium. Ringberg Castle (Germany). Angiogenesis in vitro: modulation of extracellular proteolysis and cell-extracellular matrix interactions.
1991 Nov. Ciba-Geigy Limited. Basel (Switzerland). Proteolytic balance and capillary morphogenesis in vitro.
1992 June 11th International Congress on Fibrinolysis. Copenhagen (Denmark). Proteolytic balance and in vitro morphogenesis.
1992 Sept. A New Understanding of the Role of Matrix Metalloproteinases in Tumor Biology, Upjohn Company/Brook Lodg. Kalamazoo (MI, USA). Proteolytic balance and morphogenesis of the microvasculature.
1992 Sept. Department of Cell Biology, New York University Medical Center. New York (USA). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
- 52 - 1992 Nov. VIIth International Symposium on the Biology of Vascular Cells. San Diego (CA, USA). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
1992 Nov. Department of Pathology, University of Washington. Seattle (WA, USA). Angiogenesis in vitro: cytokine interactions and extracellular proteolysis.
1993 June NATO Advanced Study Institute on Angiogenesis: Molecular Biology, Clinical Aspects. Rhodes (Greece). Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis.
1993 Nov. Banbury Center conference on Mechanisms of Developmental and Tumor Angiogenesis, Cold Spring Harbor Laboratory. New York (USA). Angiogenesis in vitro: cytokine interactions and extracellular proteolysis.
1993 Nov. Department of Pathology, Yale University. New Haven (CT, USA). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1993 Nov. Swiss Connective Tissue Society Meeting. Geneva (Switzerland). Proteolytic balance and capillary morphogenesis in vitro.
1994 March Union des Sociétés Suisses de Biologie Expérimentale. Bern (Switzerland). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 April Growth Factor Club, Departement Forschung, Kantonsspital. Basel (Switzerland). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 April Max-Planck-Arbeitsgruppen für Rheumatologie. Erlangen (Germany). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 April Max-Planck-Institut für Physiologische und Klinische Forschung. Bad Nauheim (Germany). Angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 April European Kidney Research Forum, Kloster Banz. Erlangen/Nürnberg (Germany). Plenary lecture: Regulation of angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis.
1994 Aug. VIIIth International Symposium on the Biology of Vascular Cells. Heidelberg (Germany). Angiogenesis in vitro: cytokine interactions and balanced proteolysis.
1994 Sept. Max-Delbrück-Centrum für Molekulare Medizin, Franz-Volhard-Klinik. - 53 - Berlin-Buch (Germany). Angiogenesis.
1994 Sept. Schering AG, Institute of Cellular and Molecular Biology. Berlin (Germany). Angiogenesis in vitro: mechanisms and modulators.
1994 Nov. Swiss Society for Oncology. Bern (Switzerland). Angiogenesis in vitro: mechanisms and modulators.
1995 Feb. Keystone Symposium on Tumor Cell Invasion and Motility. Tamarron (CO, USA). Angiogenesis: a balance between positive and negative regulators.
1995 April Celltech Therapeutics. Slough (UK). Angiogenesis: a balance between positive and negative regulators.
1995 May Finsen Laboratory. Denmark (Copenhagen). Angiogenesis: a balance between positive and negative regulators.
1995 May 2nd Franz-Volhard-Symposium on Mechanisms of Angiogenesis. Berlin-Buch (Germany). Angiogenesis: mechanisms and modulators.
1995 July Gordon Research Conference on Matrix Metalloproteinases. Proctor Academy. Andover (NH, USA). Angiogenesis: mechanisms and modulators.
1995 Sept. Institute for Molecular Pathology. Vienna (Austria). Angiogenesis: a balance between positive and negative regulators.
1995 Oct. 57th annual meeting of the Société Suisse d'Anatomie, d'Histologie et d'Embryologie. Geneva (Switzerland). Plenary lecture: Clinical applications of angiogenesis research: tilting the balance between positive and negative regulators.
1995 Nov. Boehringer Ingelheim International Conference on Angiogenesis and Anti- angiogenesis. Titisee (Germany). Angiogenesis: a balance between positive and negative regulators.
1996 April Workshop entitled "Angiogenesis: mechanistic insights and disease" at the 30th Annual Meeting of the European Society for Clinical Investigation. Interlaken (Switzerland). Angiogenesis: a balance between positive and negative regulators.
1996 Sept. Symposium entitled "Fallout healing: blood-borne endothelial stem cells", The Hope Heart Institute and Providence Medical Center. Seattle (WA, USA). Endothelial cell ontogeny and mechanisms of vascular formation.
1996 Sept. IXth International Vascular Biology Meeting. - 54 - Seattle (WA, USA). Angiogenesis-regulating cytokines in context.
1996 Sept. 78e réunion annuelle de la Société Suisse de Dermatologie et Vénérologie. Geneva (Switzerland). Régulation positive et negative de l'angiogenèse: de la biologie cellulaire aux applications cliniques.
1997 March Institut für Genetik, Forschungszentrum Karlsruhe. Karlsruhe (Germany). Angiogenesis: a balance between positive and negative regulators.
1997 May Novo-Nordisk. Copenhagen (Denmark). Manipulating angiogenesis: from basic science to the bedside.
1997 May Haartman Institute, University of Helsinki, Helsinki (Finland). Manipulating angiogenesis: from basic science to the bedside.
1997 Aug. Gordon Research Conference on Angiogenesis and Microcirculation. Salve Regina University. Newport (RI, USA). Balance and context: paradigms which reveal complexity in the regulation of angiogenesis.
1997 Sept. Philippe Laudat Conference on Biology and Physiopathology of Angiogenesis. Aix-les-Bains (France). Angiogenesis: a balance between positive and negative regulators.
1997 Dec. Institut d‟Embryologie du CNRS et du Collège de France. Nogent Sur Marne (France). Balance and context: regulatory paradigms for angiogenesis.
1998 Feb. Sir William Dunn School of Pathology. Oxford (UK). Balance and context: regulatory paradigms for angiogenesis.
1998 Feb. 4th Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). What is angiogenesis: mechanisms of angiogenesis.
1998 March ImClone Systems, Inc. New York (NY, USA). Manipulating angiogenesis: from basic science to the bedside.
1998 March Keystone Symposium on Angiogenesis and Vascular Remodelling. Steamboat Springs (CO, USA). Balance and context: regulatory paradigms for angiogenesis.
1998 June AACR/APMIS conference on proteases and protease inhibitors in cancer. Nyborg (Denmark). Balance and context: regulatory paradigms for angiogenesis.
1999 Feb. 5th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). - 55 - Angiogenesis and mechanisms of vessel wall assembly.
1999 Feb. Société de Biologie. Paris (France). Angiogenèse et assemblage de la paroi vasculaire.
1999 April Journées Recherche Sciences de la Vie et de la Santé, Université Joseph Fourier, Grenoble I. Grenoble (France). Plenary lecture: Angiogenèse: de la biologie cellulaire aux applications cliniques.
1999 May Annual European Vascular Biology Association meeting: endothelial cell activation: inflammation and angiogenesis. Baden (Austria). Werner Risau memorial lecture: Angiogenesis and vessel wall formation: from cell biology to the clinic.
1999 May Laboratoire de biologie moleculaire et génie génétique, Faculté des Sciences, Université de Liège. Liège (Belgium). Angiogenesis and vessel wall assembly: from cell biology to the clinic.
1999 June Institute for Medical Radiobiology of the University of Zurich and the Paul Scherrer Institute Villigen (Switzerland) Angiogenesis and vessel wall assembly: mechanistic insights and therapeutic targets.
1999 July Oncology Workshop, Merck KGaA Darmstadt (Germany) Angiogenesis and vessel wall assembly: mechanistic insights and therapeutic targets.
1999 Aug. Transgène S.A. Strasbourg (France) Angiogenèse et morphogenèse de l‟arbre vasculaire: de la biologie cellulaire aux applications cliniques.
1999 Sept. Molecular and Cellular Biology of Plasminogen Activation. Les Diablerets (Switzerland) The PA/plasmin system in PymT-induced vascular tumor formation.
1999 Oct. Journée rétine. Nyon (Switzerland) Angiogenèse et facteurs de croissance.
2000 Jan. IBC conference on Therapeutic Control of Angiogenesis. London (UK) Overview of angiogenesis concepts: exploring new opportunities for clinical development.
2000 Jan. 6th Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). Angiogenesis and mechanisms of vessel wall assembly.
2000 April Department of Clinical Research, University of Bern. - 56 - Bern (Switzerland). Manipulating angiogenesis: from cell biology to the clinic.
2000 Sept. XXVII Congress of the European Society for Artificial Organs. Lausanne (Switzerland). Plenary lecture: Mechanisms of angiogenesis: applications to the vascularization of artificial organs.
2000 Sept. XIth International Vascular Biology Meeting. Geneva (Switzerland). Plenary lecture: VEGF-C-mediated lymphangiogenesis promotes tumour metastasis.
2000 Oct. 9th Congress of the European Academy of Dermatology and Venerology. Geneva (Switzerland). Plenary lecture: Clinical applictions of angiogenesis research.
2001 Jan. 7th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). Cytokine regulation of vascular tree formation.
2001 Feb. 1st International workshop on new therapeutic targets in vascular biology. Geneva (Switzerland). Lymphangiogenesis and tumor metastasis.
2001 May Meeting of the “Hinterzartener Kreis für Krebsforschung/Cancer Research” organized by the Deutsche Forschungsgemeinschaft. Cadenabbia (Italy). Lymphangiogenesis and tumor metastasis.
2001 May Institute of Molecular Oncology, Tumor Biology Center. Freiburg (Germany). VEGF-C-mediated lymphangiogenesis promotes tumour metastasis.
2001 May 3rd Symposium on the Biology of Endothelial Cells. Pathophysiology of the endothelium: vascular and infectious diseases. Giessen (Germany). VEGF-C-mediated lymphangiogenesis promotes tumour metastasis.
2001 June EntreMed Inc. Rockville (MD, USA). VEGF-C-induced lymphangiogenesis: a novel therapeutic target for tumor metastasis.
2001 June The Derald H. Ruttenberg Cancer Center, Mount Sinai Medical Center. New York (NY, USA). Lymphangiogenesis and tumor metastasis.
2001 June ImClone Systems Inc. New York (NY, USA). VEGF-C-mediated lymphangiogenesis mediates tumor metastasis.
2001 June Swiss Institute for Applied Cancer Research. Oerlikon (Switzerland). Lymphangiogenesis and metastasis.
- 57 - 2001 July Merck KGaA. Darmstadt (Germany). Lymphangiogenesis and tumor metastasis.
2001 July XVIIIth Congress of the International Society on Thrombosis and Hemostasis. Paris (France). State of the art lecture: Extracellular proteolysis and angiogenesis.
2001 Sept. I.S.L. XVIII International Congress of Lymphology. Genova (Italy). Tumor lymphangiogenesis in Rip.VEGF-C transgenic mice.
2001 Nov. Department of Pathology, University of Bonn. Bonn (Germany). Lymphangiogenesis and tumor metastasis: myth or reality.
2001 Nov. PALM AG MicroLaser Systems workshop on laser capture microdissection. Bernried (Germany). VEGF-C-mediated lymphangiogenesis promotes tumor metastasis.
2002 Jan. Sir William Dunn School of Pathology. Oxford (UK). Lymphangiogenesis and tumor metastasis: myth or reality.
2002 Jan. 8th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva (Switzerland). First presentation: Angiogenesis and vessel wall assembly. Second presentation: Cell-based delivery of angiogenic growth factors.
2002 Feb. Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis. Ventura (CA, USA). Proteolysis in angiogenesis and lymphangiogenesis.
2002 Feb. 8th Biennial Meeting of the International Society for Applied Cardiovascular Biology. St. Gallen (Switzerland). Cell-based delivery of angiogenic growth factors.
2002 June Angiogenesis: basic mechanisms and therapeutic implications. Monte Verita, Ascona (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 July Angiogenesis Platform, Novartis. Basel (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 Aug. Serono Pharmaceutical Research Institute. Geneva (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 Sept. Angiogenesis: molecular mechanisms and functional interactions. Kloster Seeon (Germany). VEGF-C-mediated lymphangiogenesis promotes tumor metastasis.
2002 Oct. 6ème Journée d'Interaction des Groupes de Recherche des Facultés de Médecine - 58 - de Genève et Lausanne. Changins (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 Nov. Novartis Foundation (prev. Ciba Foundation) symposium no. 256 on Inflammation and Cancer. London (UK). Lymphangiogenesis and tumor metastasis.
2002 Nov. Swiss Society for Oncology meeting on “Breast cancer: biology and therapy”. Lausanne (Switzerland). Lymphangiogenesis and tumor metastasis.
2002 Nov. Austrian Vascular Biology Organization. Vienna (Austria). Plenary lecture: The lymphatic vascular system: a renaissance.
2003 Jan. “Onkologische Grundlagenforschung” seminar series, University of Basel. Basel (Switzerland). Lymphangiogenesis and tumor metastasis.
2003 Feb. New Therapeutic Targets in Vascular Biology. Geneva (Switzerland). Lymphangiogenesis and tumor metastasis.
2003 Feb. Signaling in breast cancer and new therapeutic approaches. Nice (France). Lymphangiogenesis and tumor metastasis.
2003 March 35th Annual Meeting of the Swiss Societies for Experimental Biology. Davos (Switzerland). Lymphangiogenesis and tumor metastasis.
2003 May Boehringer Ingelheim meeting on Lymphangiogenesis. Baden/Vienna (Austria). Lymphangiogenesis and tumor metastasis.
2003 June 2nd Institut Pasteur Euroconference on Angiogenesis. Paris (France). Lymphangiogenesis and tumor metastasis.
2003 June International Meeting on Angiogenesis in Cancer. Reykjavik (Iceland). VEGF-C-mediated lymphangiogenesis promotes tumor metastasis.
2003 Aug. Department of Medicine, Johannesburg General Hospital. Johannesburg (South Africa). Manipulating angiogenesis: from basic science to the bedside.
2003 Nov. 69. Jahresversammlung Schweizerische Gesellschaft für Pathologie. Ittingen (Switzerland). Lymphangiogenesis and tumor metastasis.
2003 Nov. Journées medico-chirurgicales d‟hépatologie et de gastroenterologie. Geneva (Switzerland). Métastases lymphogènes des tumours digestives.
- 59 - 2003 Dec. Wallenberg Laboratory, Sahlgrenska University Hospital. Gothenburg (Sweden). The lymphatic vascular system: a renaissance.
2003 Dec. Institute of Pathology, University of Bern. Bern (Switzerland). Lymphangiogenesis and tumor metatsasis.
2004 March Gordon Research Conference on Molecular Mechanisms in Lymphatic Function and Disease. Ventura (CA, USA). Lymphangiogenesis and tumor metatsasis.
2004 Aug. Biomedicum Helsinki. Helsinki (Finland). Hemangiomas and vascular malformation: new insights into their pathogenesis and treatment.
2004 Aug. Regenerative Medicine. Turku (Finland). The lymphatic vascular system: a renaissance.
2004 Oct. Roche In Vitro Diagnostics Forum. Johannesburg (South Africa). Genes guide the way - a promise of new technology.
2004 Oct. Belgian Society for Cell and Developmental Biology. Liège (Belgium). Lymphangiogenesis and tumor metastasis.
2005 Feb. Roche Molecular Diagnostics. Cape Town (South Africa). Pharmacogenetics.
2005 Feb. Department of Molecular Medicine and Hematology, University of the Witwatersrand. Johannesburg (South Africa). Vascular malformations and hemangiomas: from cell biology to the clinic.
2005 June Roche 1st Central and Eastern European In Vitro Diagnostics Forum. Athens (Greece). Genes lead the way: a promise of new technology.
2005 June Department of Molecular Medicine and Hematology, University of the Witwatersrand. Johannesburg (South Africa). The power of pharmacogenetics.
2005 Aug. Nelson R. Mandela School of Medicine, University of KwaZulu-Natal. Durban (South Africa). The power of pharmacogenetics.
2005 Nov. Merck KGaA. Darmstadt (Germany). Insights into the mechanisms of angiogenesis: identification of novel therapeutic targets.
2006 May University of Ulm, Department of Medicine. Ulm (Germany). Cell-based therapy in the heart – the South African potential. - 60 -
2006 Aug. 44th Annual Congress of the South African Gastroenterology Society. Port Elizabeth (South Africa). The genetics of obesity.
2006 Sept. XXIXth International Congress of the International Society of Blood Transfusion. Cape Town (South Africa). State-of-the-art lecture: Stem cell plasticity.
2006 Sept. Society for the Advancement of Blood Management Annual Meeting. Jersey City (NJ, USA). Plenary lecture: South African Blood Conservation Program.
2007 Feb. Biological Psychiatry Congress 2007. From Molecules to Mind: Bridging the Gap. Somerset West (South Africa). Amplichip CY450 genotype profiling: improving treatment outcomes in psychiatric disorders.
2007 May South African Medicolegal Society. Pretoria (South Africa). Stem cells: current reality and future promise.
2007 June Bioethics Forum on Public and Private Stem Cell Banking. Pretoria (South Africa). Public and private stem cell banking: scientific arguments.
2007 Aug. AfricaBio: Biotechnology and Stem Cell Research. Centurion (South Africa). Cell-based therapy in South Africa.
2007 Sept. South African division of the International Association for Dental Research. Centurion (South Africa). Stem cells: what are they and how will they affect dentistry in the future?
2007 Sept. Bio2Biz SA 2007. Cape Town (South Africa). Stem cells. Current reality and future promise.
2008 Jan. SASOM Bariatric Workshop. Pretoria (South Africa). Genetics and epigenetics of obesity: key points.
2008 July National Biotechnology Advisory Committee Workshop. Pretoria (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2008 Sept. Bio2Biz 2008. Johannesburg (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2008 Oct. International Physiotherapy Congress. Pretoria (South Africa). Stem cells: current reality and future promise.
2008 Oct. Biotechnology in Medical Research – Media Round Table (SAASTA/PUB). Cape Town (South Africa). Health Biotech in South Africa. - 61 -
2009 Feb. College of Agriculture and Environmental Sciences, University of South Africa. Johannesburg (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2009 May California NanoSystems Institute (CNSI), University of California, Los Angeles. Los Angeles (CA, USA). Bedside to bench: defining the market in health biotechnology in South Africa.
2009 May In Vivo and Cellular Molecular Imaging Center Seminar Series, Johns Hopkins University School of Medicine. Baltimore (MD, USA). Bedside to bench: defining the market in health biotechnology in South Africa.
2009 May The Human Tissue Regulatory Environment. Pretoria (South Africa). The Stem Cell Regulatory Environment in South Africa.
2009 July SA Bio Plan – Emory Goizueta Business School. Stellenbosch (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2009 Aug. Innov8 Pub @ Hub. Pretoria (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2009 Sept. Department of Jurisprudence, School of Law, University of South Africa. Pretoria (South Africa). The Stem Cell Regulatory Environment in South Africa: operating in a regulatory vaccuum.
2009 Sept. Bio2Biz. Durban (South Africa). Impediments to the establishment of stem cell technology in South Africa.
2009 Sept. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). 1. Bedside to bench - defining the market in health biotechnology in South Africa. 2. Cell-based thearpy.
2009 Nov. 31st South African National Blood Transfusion Congress. Johannesburg (South Africa). Sustainability strategies in public cord blood banking.
2009 Nov. Technology transfer in South Africa (SARIMA/WBI). Cape Town (South Africa). A meta-analysis of studies on tech transfer in South Africa.
2009 Nov. Stem Cells – Media Round Table (SAASTA/PUB). Durban (South Africa). Cell-based therapy.
2010 Feb. Steve Biko Centre for Bioethics, University of the Witwatersrand. Reproductive Health – Ethics and Law. Johannesburg (South Africa). Cord blood collection and banking. - 62 -
2010 March South African Transplantation Society. 3rd Controversies in Transplantation Meeting. Mount Grace (South Africa). Human tissue legislation: revision of Chapter 8 of the NHA and associated regulations.
2010 March South African Genetics Society 21st Congress. Bloemfontein (South Africa). Genomic Sovereignty.
2010 May Bestmed Annual General Meeting. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2010 May Department of Molecular Medicine and Hematology, Wits University. Johannesburg (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2010 Aug. Transplantation Indaba Cape Town (South Africa). Overview of stem cell principles and legislation.
2010 Aug. Faculty Day, Faculty of Health Sciences, University of Pretoria. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2010 Sept. NBAC national workshop on Feeding the Biotechnology Pipeline. Pretoria (South Africa). The regulatory environment and the new Bio-economy in South Africa.
2010 Oct. Human tissue use: medico-legal and ethical implications. Durban (South Africa). The Amendments to Chapter 8 of the National Health Act and Regulations thereto.
2010 Oct. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2010 Nov. Medi-Clinic Southern Africa Management Committee. Stellenosch (South Africa). Cell-based therapy.
2010 Nov. Biotechnology landscape in South Africa – Media Round Table (SAASTA/PUB). Cape Town (South Africa). Bedside to bench: defining the market in health biotechnology in South Africa.
2011 Jan. Muelmed Hospital Physiotherapy/Rehab Department. Pretoria (South Africa). Cell-based therapy.
2011 March University of Pretoria and the South African Paediatric Association. Update 2011. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2011 March Post-graduate Diploma in Transfusion Medicine. University of the Free State. Bloemfontein (South Africa). Cord blood stem cell banking.
- 63 - 2011 April The Nestle Nutrition Institute Africa and the Departnment of Human Nutrition (University of Pretoria) – 8th CNE. Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2011 May Pan-African Ethics, Human Rights and Medical Law. Johannesburg (South Africa). The southern African Human Genome Programme: some ethical, legal and social issues.
2011 May 2nd Neuroscience Day, University of Pretoria. Pretoria (South Africa). Epigenetics in the Neurosciences.
2011 July Department of Immunology, University of Cape Town. Cape Town (South Africa). Cord blood stem cell banking: a realistic option for South Africa.
2011 Aug. Department of Science and Technology. Pretoria (South Africa). Genomic sovereignty.
2011 Aug. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2011 Sept. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Cape Town (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2011 Oct. University of Limpopo. Polokwane (South Africa). Cell-based therapy.
2011 Oct. South African Society of Physiotherapy. Pretoria (South Africa). Cell-based therapy.
2011 Nov. Ethics Workshop, Faculty of Health Sceinces, University of Pretoria. Pretoria (South Africa). Ethical, legal and social issues of the Southern African Human Genome Programme.
2011 Nov. SAASTA/PUB Critical Thinker‟s Forum on the Southern African Human Genome Programme. Cape Town (South Africa). Human Genome introductory lecture.
2012 Feb. Division of Human Genetics, NHLS and University of the Witwatersrand. Johannesburg (South Africa). Cell-based therapy.
2012 March NBAC National Workshop: Bioprospecting South Africa‟s biodiversity: a driver for the new bioeconomy. Pretoria (South Africa). The human genome.
2012 June Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Grahamstown (South Africa). Lecture 1: Bedside to bench - defining the market in health biotechnology in South Africa. - 64 - Lecture 2: Cell-based therapy.
2012 July Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Durban (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2012 August Legal aspects relating to the applications of biotechnology, College of Law, Unisa. Pretoria (South Africa). Human tissue legislation in South Africa – a need for self-regulation?
2012 Aug. Medical malpractice litigation seminar, Institute for Cellular and Molecular Medicine. & Sept. Pretoria (South Africa). Medical malpractice litigation in South Africa.
2012 Sept. Sci-Enza Sci-Enza, in collaboration with Public Understanding of Biotechnology (PUB). Pretoria (South Africa). Mapping the human genome: the dawning of a new era in healthcare.
2012 Sept. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Pretoria (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2012 Oct. Certificate in Bioentrepreneurship (Continuing Education, University of Pretoria). Cape Town (South Africa). Bedside to bench - defining the market in health biotechnology in South Africa.
2012 Oct. 9th Expert Lecture, University of Pretoria. Pretoria (South Africa). Stem cells: current reality and future promise.
2012 Nov. swissnexDay‟12: Brain Circulation. Bern (Switzerland). Emigration des cerveaux.
2012 Nov. SAASTA/PUB Critical Thinker‟s Forum on Stem Cells. Doornkloof (South Africa). Stem Cells introductory lecture.
2013 March 16th International Society of Radiolabelled Blood Elements Congress. Pretoria (South Africa). Stem Cell Research and Therapy: an Overview.
2013 May Vitalab Journal Club. Johannesburg (South Africa). Stem Cell Research and Therapy: an Overview.
2013 May 4th Annual PD Rose Plenary Lecture, Rhodes University. Grahamstown (South Africa). Stem Cells: the Hype and the Hope.
2013 May Institute for Food, Nutrition and Wellbeing, University of Pretoria. Pretoria (South Africa). We are what we eat – at the interface between molecular medicine and nutrition.
2013 June Otorinolaryngology journal club. Pretoria (South Africa). Medical malpractice litigation. - 65 -
2013 June Obstetrics and Gynaecology meeting on medical malpractice and legal matters. Johannesburg (South Africa). Medical malpractice litigation.
2013 July Pretoria Boys High School. Pretoria (South Africa). Stem cells: the hype and the hope.
2013 August International Centre for Genetic Engineering & Biotechnology (ICGEB). Cape Town (South Africa). Stem cells: the hype and the hope.
2013 August Faculty Day, Faculty of Health Sciences, University of Pretoria Pretoria (South Africa). The lymphatic tree: the often forgotten second vascular system.
2013 August Ethical and Legal Issues on Biobanking, College of Law, Unisa Pretoria (South Africa). Private versus public biobanks.
2013 Sept. International Association for Dental Research (SA Division) Annual Congress Kammeeldrift (South Africa). Stem cells: the hype and the hope.
2013 Sept. 41st Conference of the Physiology Society of Southern Africa Roode Vallei (South Africa). Stem cells: the hype and the hope.
2013 Sept. Postgraduate Diploma in Transfusion Medicine, University of the Free State Bloemfontein (South Africa). Lecture 1: Stem cells: the hype and the hope. Lecture 2: Human tissue legislation.
2013 Oct. The future and sustainability of biobanks in South Africa to support indigenous research. Sandringham (South Africa). SA National Health Act and biobanking.
2013 Oct. 15th Biennial Congress of the Southern African Society for Human Genetics. Sandton (South Africa). Lecture 1: Objectives and future medical relevance of the SAHGP. Lecture 2: Mesenchymal stem cells: adult stem cells with potentially wide therapeutic applications.
2013 Oct. Emerging Health Technologies Seminars, CSIR. Pretoria (South Africa). Stem cells: the hype and the hope.
2013 Oct. Launch of the DST/NRF SARChI Chair in Mathematical Models and Methods in Bioengineering and Biosciences. Pretoria (South Africa). Angiogenesis and lymphangiogenesis: importance in tumor growth and metastasis.
2013 Nov. Dept. of Molercular Medicine and Haematology, University of the Witwatersrand. Johannesburg (South Africa). Stem cells: the hype and the hope.
- 66 - 2013 Nov. Ethics Workshop, Faculty of Health Sceinces, University of Pretoria. Pretoria (South Africa). Medical malpractice litigation in South Africa.
2013 Nov. Seminar Day, Genomics Research Institute, University of Pretoria. Pretoria (South Africa). The Human Genome – a novel perspective.
2013 Nov. University of the West Indes, Mona Campus. Kingston (Jamaica). Angiogenesis and lymphangiogenesis – importance in tumor growth and metastasis.
2013 Nov. University of Technology. Kingston (Jamaica). Angiogenesis and lymphangiogenesis – importance in tumor growth and metastasis.
2013 Nov. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus. Kingston (Jamaica). The Human Genome.
2013 Nov. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus. Kingston (Jamaica). Stem cells – current reality and furure promise.
2014 Feb. 2014 National Life Science Conference of the IEB. Johannesburg (South Africa). Stem cells – current reality and furure promise.
2014 August SASOG Gauteng North. Pretoria (South Africa). Sex determination and gender identity.
2014 August International Conference on Tissue Engineering and Regenerative Medicine. Pretoria (South Africa). Establishment of a sustainable public cord blood stem cell bank for South Africa.
2014 Sept. Consensus study on homosexuality. Bellagio (Italy). Sex determination and gender identity.
2014 Nov. Bridging Science, Business, and Politics: the Role of Responsible Leadership in Creating the Necessary Transition to a Sustainable Global Economy. Pretoria (South Africa). Sustainable outcomes in stem cell and genomics research - the role of responsible leadership.
2014 Nov. Opportunities and responsibilities in genomic and stem cell research in South Africa. Potchefstroom (South Africa). Building capacity to investigate the role of mitochondrial DNA variants in Black African populations.
2014 Nov. 3rd Worldwide Network for Blood and Marrow Transplantation workshop (in partnership with the WHO) Cape Town (South Africa). Human Tissue Legislation.
2014 Dec. CSIR course on Induced Pluripotent Stem Cell Technology. Pretoria (South Africa). 1. Stem cells in SA: history and current status 2. Stem cell legislation/ethics/clinical application
2014 Dec. Du Tissu Graisseux a la Cellule Souche: Medecine et Chirurgie Regenerative Geneva (Switzerland). - 67 -
Les possibilites therapeutiques des cellules souches en 2014. - 68 -
ABSTRACTS
Published abstracts
1. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Endothelial cell-matrix interactions in angiogenesis. Coll. Rel. Res. 8(6): 516, 1988.
2. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Proteolytic balance and capillary morphogenesis in vitro. J. Mol. Cell. Cardiol. 23 (Suppl. 5): S16, 1991.
3. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Regulation of capillary morphogenesis in vitro. J. Cell. Biochem. Suppl. 16F: 75, 1992.
4. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Proteolytic balance and in vitro morphogenesis. Fibrinolysis 6 (Suppl. 2): 31, 1992.
5. Pepper M.S., Wagner E., Fotsis T., Schweigerer L., Ferrara N., Risau W., Orci L., Vassalli J.-D. and Montesano R.: Angiogenesis: a balance between positive and negative regulators. J. Cell. Biochem. Suppl. 19B: 5, 1995.
6. Soriano J.V., Pepper M.S., Nakamura T., Orci L. and Montesano R.: Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. Experientia 51: A62, 1995.
7. Mandriota S.J., Seghezzi G., Vassalli J.-D., Montesano R., Mignatti P. and Pepper M.S.: Vascular endothelial growth factor modulates extracellular proteolytic activity in vascular endothelial cells. Experientia 51: A65, 1995.
8. Pepper M.S., Vassalli J.-D., Orci L. and Montesano R. Regulation of angiogenesis in vitro: cytokine interactions and balanced extracellular proteolysis. Kidney Int. 47(2): 659, 1995.
9. Zimrin A.B., Pepper M.S., Montesano R. and Maciag T. An antisense oligonucleotide to the notch ligand jagged promotes angiogenesis in bovine microvascular endothelial cells (BMEC) on collagen gels. FASEB J 10(6): A1094, 1996
10. Lucas, R., Sablon E., Echtenacher B., Ameloot P., Magez S., Juillard P., Pepper M.S., Vandenabeele P., Hofmeister R., Bosman F., Fransen L., Montesano R., Grau G.E. and De Baetseiler P. A mouse TNF mutein with reduced toxicity, but with equal tolerizing, anti-angiogenic and protective activities. Eur. Cytokine Netw. 7(2): 236, 1996.
11. Lucas, R., Lou J.N., Donati Y.R.A., Mandriota S.J., Decrind C., Pepper M.S., Monso-Hinard C., Moore M.W., Bluethmann H. and Grau G.E. Both TNF receptors are needed to mediate TNF-induced cytotoxicity in microvascular endothelial cells. Eur. Cytokine Netw. 7(2): 235, 1996.
12. Pepper M.S., Mandriota S.J., Vassalli J,-D., Orci L. and Montesano R. Angiogenesis: a balance between positive and negative regulators. Eur. J. Clin. Invest. 26 (Suppl. 1): A38, 1996.
13. Mandriota S.J., Menoud P.-A. and Pepper M.S. Regulation of vascular endothelial growth factor receptor 2/FLK-1 expression in vascular endothelial cells. Eur. J. Clin. Invest. 26 (Suppl. 1): A38, 1996.
14. Gorden D.L., Mandriota S.J., Montesano R. and Pepper M.S. Modulation of vascular endothelial growth factor expression in isolated islets of Langerhans. Eur. J. Clin. Invest. 26 (Suppl. 1): A39, 1996.
15. Zimrin A.B., Pepper M.S., Montesano R. and Maciag T. An antisense oligonucleotide to the Notch ligand Jagged promotes angiogenesis in bovine microvascular endothelial cells (BMEC) on collagen gels. FASEB J. 10(6): 547, 1996. - 69 -
16. Masouyé I., Pepper M.S., Saurat J.H., Veerkamp J.H., Siegenthaler G. Endothelial cells from human skin express epidermal fatty acid-binding protein (E-FABP). J. Invest. Dermatol. 107(2): C18, 1996.
17. Hagens G., Masoye I., Pepper M.S., Madsen P., Saurat J.H., Veerkamp J.H and Siegenthaler G. Endothelial cells from human blood capillaries also express the epidermal fatty acid-binding protein. J. Invest. Dermatol. 107(3): 25, 1996
18. Thommen R., Humar R., Misevic G., Pepper M.S. and Battegay E.J. PDGF-BB increases endothelial migration and cord movements during angiogenesis in vitro. Microcirculation 4: 143, 1997.
19. Lucas R., Holmgren L., Mandriota S.J., Jimenez B., Garcia I., Montesano R., Grau G.E., Shing Y. and Pepper M.S. Cytotoxicity of TNF versus angiostatin in microvascular endothelial cells in vitro. Eur. J. Surg. Oncol. 24: 224, 1998.
20. Miralbell R., Tolnay M., Bieri S., Sappino A.P., Probst A., Pizzolato G. and and Pepper M.S. Pediatric medulloblastoma: prognostic significance of MIB-1, p53, bcl-2, and von Willebrand immunoreactivity. Med. Ped. Oncol. 31: 229, 1998.
21. Olofsson B., Korpelainen E., Pepper M.S., Mandriota S.J., Kumar V., Aase K.A.Y., Gunji Y., Alitalo K. and Eriksson U. VEGF-B binds to VEGFR-1 and regulates plasminogen activator activity in endothelial cells. Mol. Biol. Cell 9 (Suppl 5): 114A, 1998.
22. March K.L., Nguyen A.T., Gurudutt V.V., Fineberg N., Mahomed Y., Sharp T., Aufiero T., Brown J. and Pepper M. Human pericardial fluid often displays potent angiogenic inhibitory activity in patients with cardiac ischemia. Circulation 100(18): 407, 1999.
23. Pepper M.S., Rosnoblet C. and Kruithof E.K.O. Synergistic induction of tPA by VEGF and bFGF and localization of tPA to Weibel-Palade bodies in bovine microvascular endothelial (BME) cells. Fibrinolysis Proteolysis 14 (Suppl. 1): 20, 2000.
24. Tille J.-C., Wood J., Mandriota S.J., Schnell C., Ferrari S., Mestan J. and Pepper M.S. VEGFR-2 tyrosine kinase inhibitors inhibit bFGF- and VEGF-induced angiogenesis in vivo and in vitro. J. Submicrosc. Cytol. Pathol. 32 (30): 456, 2000.
25. Nisato R., Tille J.- angiogenesis. J. Submicrosc. Cytol. Pathol. 32(3): 435, 2000.
26. Alizadeh N., Pepper M.S. and Pittet B. A model of ulcer healing in the ischemic limb. J. Submicrosc. Cytol. Pathol. 32(3): 430, 2000.
27. Alizadeh N., Pittet B., Pyke C., Baetens D., Montandon D., Ezban M. and Pepper M.S. Active-site inactivated FVIIa (FVIIai) increases viability in a skin flap model of acute ischemia. J. Submicrosc. Cytol. Pathol. 32(3): 409, 2000.
28. Mandriota S.J., Jussila L., Jeltsch M., Compagni A., Prevo R., Banerji S., Huarte J., Baetens D., Montesano R., Jackson D., Orci L., Alitalo K., Christofori G. and Pepper M.S. VEGF-C-mediated lymphangiogenesis promotes tumour metastasis. J. Submicrosc. Cytol. Pathol. 32(3): 384, 2000.
29. Schlaudraff K.U., Pepper M., Ehrenburg I.V., Tkatchouk E.N., Montandon D. and Pittet B. Influence of intermittent hypoxia training on the survival of ischemic dorsal random skin flaps in the rat. Hypoxia Med. J. 9: 29, 2001.
30. Pepper M.S. Cell-based delivery of angiogenic growth factors. Cardiovasc. Pathol. 11: 8, 2002.
- 70 - 31. Podograbinska S., Velasco P., Detmar M., Pepper M., Jackson D. and Skobe M. Molecular profile of the lymphatic endothelium. Lymphatic Res. Biol. 1: 92, 2003.
32. Bochaton-Piallat M.L., Hao H., Verin V., Camenzind E., Pepper M.S. and Gabbiani G. Porcine coronary artery smooth muscle cells are phenotypically heterogeneous. Arterioscl. Thromb. Vasc. Biol. 23(5): A47, 2003
33. Mathe Z., Dupraz P., Bosco D., Bucher P., Zbinden M., Rinsch C., Thorens B., Berney T, Pepper M.S. Retroviral transduction of pancreatic beta-cells by VEGF-164 improves glycemic control in a syngeneic model of islet cell transplantation. Transplantation 76(4): S60-S61, 2003.
34. Wernert N., Okuducu A. and Pepper M.S. Ets 1 is expressed in capillary blood vessels but not in lymphatics. Pathol. Res. Practice. 200(4): 260, 2004
35. Mathe Z., Dupraz P., Zbinden M., Bosco D., Filo A., Bucher P., Rinsch C., Thorens B., Berney T, Pepper M.S. Regulated gene expression of VEGF-164 by pancreatic beta-cells improves revascularization and engraftment after transplantation. Diabetologia 47: A181, 2004.
36. Nisato R.E., Harrison J.A., Buser R., Orci L., Rinsch C., Montesano R., Dupraz P. and Pepper M.S. Generation and characterization of telomerase-transfected human lymphatic endothelial cells with an extended lifespan. Anticancer Res. 24(5D): 3582, 2004.
37. Hao H., Geinoz A., Ropraz P., Verin V., Camenzind E., Pepper M.S, Sanchez J.C., Gabbiani G. and Bochaton-Piallat M.L. Heterogeneity of smooth muscle cell populations cultured from pig coronary artery. Cardiovasc. Pathol. 13(3, Supplement): S159-160, 2004.
38. Friedrichs N., Hahne J., Pepper M.S., Rommerscheidt-Fuss U., Buettner R., Stelzner F and Wernert N. Immunohistochemical quantification of lympf vessels, VEGF-C and VEGFR-3 in human sarcomas. Pathol. Res. Practice. 201(3): 204, 2005.
39. Rubbia-Brandt L., Terris B., Giostra E., Dousset B., Morel P. and Pepper M.S. Lymphatic vessel density and VEGF-C expression correlate with malignant behaviour in human pancreatic endocrine tumors. Modern Pathol. 18 (Suppl 1): 285A, 2005.
40. Rubbia-Brandt L., Terris B., Giostra E., Dousset B., Morel P. and Pepper M.S. Lymphatic vessel density and VEGF-C expression correlate with malignant behaviour in human pancreatic endocrine tumors. Lab. Invest. 85 (Suppl 1): 285A, 2005.
41. Ballmer-Hofer K., Suarez S.C., Hoffmann U., Pepper M. and Nisato R. Altered signalling of an inhibitory VEGF-A splice variant results from a defect in heparin binding: implications for angiogenesis in development and tissue repair. FEBS J. 272 (Suppl 1): 218, 2005.
42. Pepper M. AmpliChip CYP450 genotype profiling for improving treatment outcomes in psychiatric patients. S. Afr. J. Psychiatry 13(1): 33-34, 2007.
43. Ammar A., Muhammed R., Patel P., Salmi M., Pepper M., Nissato R., Paish E.C., Ellis I. and Martin S.G. The role of CLEVER-1 in breast tumour metastasis. Eur. J. Cancer Supplements 5(3): 27, 2007.
44. van der Merwe M.T., Logan M., Pieters J.H., Sammi Y. and Pepper M.S. Sustained weight loss after an 18-month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. J. Endocrinol. Metab. Diabetes S. Afr. 12(1): 46, 2007.
45. Van der Merwe T., Logan M., Pieters J., Sammi Y. and Pepper M. Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. Int. J. Obesity 31(S1):S116, 2007.
- 71 - 46. Ammar A., Mohammed R., Salmi M., Pepper M., Paish E., Ellis I., Patel P. and Martin S.G. Role of CLEVER-1 in breast cancer metastasis. Breast Cancer Res. 10 (Suppl 2): S19-S20, 2008.
47. Logan M.G., Pepper M.S., van der Merwe M.T. and Fetter G.K. Early changes following bariatric surgery in South Africa. 43rd SEMDSA Congress. Cape Town, South Africa. 12-15 April, 2008. J. Endocrinol. Metab. Diabetes South Afr. 13(1): 35, 2008.
48. Logan M., Pepper M.S. and van der Merwe M.T. Early changes following bariatric surgery in South Africa. Int. J. Obesity 32 (Suppl 1): S51, 2008.
49. Mabeta P. and Pepper M.S. Evaluation of the antiangiogenic effects of bleomycin in vitro. J. Physiol. Sci. 59 (Suppl 1): 322, 2009.
50. Dodgen T., Cromarty D., Fickl H. and Pepper M. CYP2D6 and CYP2C19: a comparison of direct versus predicted phenotyping in a South African population. Basic Clin. Pharmacol. Toxicol. 107(Supplement s1): 259, 2010.
51. Modarressi A., Pietramaggiori G., Alizadeh N., Pepper M.S., Bochaton-Piallat M.L., Hinz B. and Pittet, B. Myofibroblasts play a key role in delayed wound healing in ischemia. Br. J. Surg. 97 (Suppl 4): S29, 2010.
52. Alessandrini M., Beltchev E., Pool R. and Pepper MS. Evaluation of the AMLprofiler in the South African context: report on preliminary findings. Blood 122 (21): online only, 2013.
53. Mabeta P, Davis P.F. and Pepper M.S. mTOR/PI3k/Akt signaling pathway in tumor angiogenesis and therapeutic targeting. Anticancer Res. 34: 6042, 2014.
Other abstracts
54. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Endothelial cell-extracellular matrix interactions in angiogenesis. Proceedings of the Symposium on Growth, Differentiation and Pathology of the Vascular Endothelium, Schloß Ringberg (Germany). 5-8 October 1988.
55. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Endothelial cell-matrix interactions and cell invasiveness in angiogenesis. Proceedings of the 19th meeting of the Federation of European Biochemical Societies, Rome (Italy). 2-7 July 1989.
56. Pepper M.S., Spray D.C., Chanson M., Montesano R. and Orci L.: Junctional communication is induced in migrating capillary endothelial cells. Proceedings of the meeting on Molecular and Cell Biology of Gap Junctions, Irsee (Germany). 18-23 July 1989.
57. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Angiogenesis in vitro: morphogenetic and invasive properties of endothelial cells. Proceedings of the meeting of the British Society for Cell Biology, Manchester (U.K.). 3-6 April 1990.
58. Vassalli J.-D., Wohlwend A., Belin D., Pepper M., Montesano R. and Orci L.: Cytokines in the control of extracellular proteolysis. Proceedings of the First International Congress on Inflammation, Barcelona (Spain). 17-22 June 1990.
59. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Proteolytic balance and capillary morphogenesis in vitro. International Symposium on Angiogenesis, St. Gallen, (Switzerland). 13-15 March 1990.
60. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Modulation of angiogenesis in vitro. International Symposium on Angiogenesis, St. Gallen, (Switzerland). 13-15 March 1990.
- 72 - 61. Pepper M.S., Vassalli J.-D., Orci L. and Montesano R.: Angiogenesis in vitro: modulation of extracellular proteolysis and cell-extracellular matrix interactions. Proceedings of the 2nd Symposium on Growth, Differentiation and Pathology of Vascular Endothelium, Ringberg Castle (Germany). 16-19 October 1991.
62. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis. Proceedings of the VIIth International Symposium on the Biology of Vascular Cells, San Diego (California, USA). 10-14 November 1992.
63. Pepper M.S., Vassalli J.-D., Sappino A.-P., Orci L. and Montesano R.: Angiogenesis in vitro: cell-matrix interactions and extracellular proteolysis. Proceedings of the NATO Advanced Study Institute on Angiogenesis: Molecular Biology, Clinical Aspects, Rhodes (Greece). 16-27 June 1993.
64. Montesano R., Pepper M.S., Vassalli J.-D. and Orci L.: Role of growth factors and extracellular matrix in angiogenesis and epithelial morphogenesis. Proceedings of the International Symposium on Developmental Endocrinology, Geneva (Switzerland). 30 September - 2 October 1993.
65. Fotsis T., Pepper M., Adlercreutz H., Hase T., Montesano R. and Schweigerer L. Genistein and angiogenesis inhibition. Proceedings of the 1st International Symposium on the role of Soy in Preventing and Treating Chronic Disease, Mesa (Arizona, USA). 20-23 February 1994.
66. Adlercreutz H., Fotsis T., Schweigerer L., Pepper M., Attalla H., Zhang Y., Wähälä C., Montesano R., Nawroth P.P. and Hase T.: Isoflavonoids and 2-methoxyestradiol: inhibitors of tumor cell growth and angiogenesis. Proceedings of the 85th AACR Annual Meeting "Novel Strategies in Chemical Chemoprevention of Cancer", San Francisco (California, USA). 10-13 April 1994.
67. Pepper M.S., Vassalli J.-D., Orci L. and Montesano R. Angiogenesis in vitro: cytokine interactions and balanced proteolysis. Proceedings of the VIIIth International Symposium on the Biology of Vascular Cells, Heidelberg (Germany). 30 August - 4 September 1994.
68. Fotsis T., Pepper M. Aktas E., Joussen A., Kruse F., Adlercreutz H., Hase T., Montesano R. and Schweigerer L.: Inhibitors of angiogenesis in human urine. Proceedings of the NATO Advanced Study Institute on Molecular Cellular and Clinical Aspects of Angiogenesis Porto Carras, Halkidiki (Greece). 16- 27 June, 1995.
69. Montesano R., Vassalli J.-D., Orci L. and Pepper M.S.: Endothelial and tubular morphogenesis. XIIIth International Congress of Nephrology, Madrid (Spain). 2-6 July, 1995.
70. Fotsis T., Pepper M., Aktas E., Joussen A., Kruse F., Adlercreutz H., Hase T., Montesano R. and Schweigerer L.: Dietary inhibitors of angiogenesis. Proceedings of the 11th IFCC European Congress of Clinical Chemistry, Tampere (Finland). 2-7 July, 1995.
71. Pepper M.S., Wagner E.F., Mandriota S.J., Vassalli J,-D., Orci L. and Montesano R. Angiogenesis: a balance between positive and negative regulators. Proceedings of the Boehringer Ingelheim International Conference on Angiogenesis and Anti-angiogenesis, Titisee (Germany). 1-5 November, 1995.
72. Pepper M.S., Montesano R. Mandriota S.J., Orci L. and Vassalli J.-D. Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis. Proceedings of the American Association for Cancer Research conference on Proteases and Protease Inhibitors in Cancer, Panama City (FL, USA). 1-5 March, 1996.
73. Hagens G., Masouyé I., Pepper M.S., Madsen P., Saurat J.H., Veerkamp J.H., Siegenthaler G. Endothelial cells from human blood capillaries also express the epidermal fatty acid-binding protein. Proceedings of the 25th meeting of the European Society for Dermatological Research, Amsterdam, The Netherlands. 28 September - 1 October, 1996.
- 73 - 74. Montesano R., Soriano J.V., Pepper M.S., Orci L. Induction of epithelial branching tubulogenesis in vitro. Proceedings of the 9th Conference of the International Society of Development, Cell Differentiation and Cancer, Pisa, Italy. 28 September - 2 October, 1996.
75. Lucas R., Lou J.N., Mandriota S., Pepper M., Suter P.M., Bluethmann H. and Grau G. TNF cytotoxicity in pulmonary microvascular endothelial cells in the presence versus absence of transcriptional inhibitor. Proceedings of the 29th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Geneva, Switzerland. 20-21 March 1996.
76. Pepper M.S. and Montesano R. Manipulating angiogenesis: from basic science to the bedside. Proceedings of the 29th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Geneva, Switzerland. 20-21 March 1996.
77. Mandriota S.J. and Pepper M.S. Regulation of vascular endothelial growth factor (VEGF) and VEGF receptor expression in vascular endothelial cells. Proceedings of the 29th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Geneva, Switzerland. 20-21 March 1996.
78. Tenan M., Diserens A.C., El Atifi M., Brunet J.F., Albertoni M., Fulci M., de Tribolet N., Feige J.J., Pepper M. and Van Meir E.G. Overexpression of thrombospondin-1 is anti-tumorigenic in glioblastoma. Proceedings of the 12th International Conference on Brain Tumour Research and Therapy, Keble College, Oxford, U.K. 20-23 September, 1997.
79. Pepper M.S. Angiogenesis. Proceedings of the 4th local drug delivery meeting and cardiovascular course on radiation and molecular strategies, Geneva, Switzerland. 26-28 February, 1998.
80. Bochaton-Piallat M.-L., Gabbiani G. and Pepper M.S. Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Proceedings of the 4th local drug delivery meeting and cardiovascular course on radiation and molecular strategies, Geneva, Switzerland. 26-28 February, 1998.
81. Lucas R., Holmgren L., Mandriota S.J., Jimenez B., Garcia I., Grau G.E., Shing Y. and Pepper M.S. Angiostatin induces apoptosis in endothelial cells. Proceedings of the 30th annual meeting of the Swiss Societies for Experimental Biology (USGEB/USSBE), Lausanne, Switzerland. 5-6 March 1998.
82. Pepper M.S. Balance and context: regulatory paradigms for angiogenesis. Proceedings of the Keystone Symposium on Angiogenesis and Vascular Remodeling, Steamboat Springs, CO, USA. 28 March - 3- April, 1998.
83. Cavallaro U., Wu Z., Pepper M.S., Montesano R. and Soria M.R. Crosstalk between angiogenic growth factors in the migration of vascular cells. Proceedings of the Keystone Symposium on Angiogenesis and Vascular Remodeling, Steamboat Springs, CO, USA. 28 March - 3-April, 1998.
84. Mandriota S.J. and Pepper M.S. Regulation of angiogenesis by interactions between positive and negative regulators. Proceedings of the Keystone Symposium on Angiogenesis and Vascular Remodeling, Steamboat Springs, CO, USA. 28 March - 3 April, 1998.
85. Pepper M.S. Balance and context: regulatory paradigms for angiogenesis. Proceedings of the AACR and APMIS meeting on Proteases and Protease Inhibitors in Cancer, Nyborg Strand, Denmark. 14-18 June, 1998.
86. Mandriota S.J and Pepper M.S. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Proceedings of the Xth International Vascular Biology Meeting, Cairns, Australia. 23-27 August, 1998.
87. Bochaton-Piallat M.-L., Gabbiani G. and Pepper M.S. Plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Proceedings of the Xth International Vascular Biology Meeting, Cairns, Australia. 23-27 August, 1998. - 74 -
88. Sleeman J. P., Steffen A., Mandriota S.J., Krishnan J. and Pepper, M.S. Lymphangiogenic factors VEGF- C and VEGF-D are expressed by tumors. Proceedings of the 5th Franz Volhard Symposium entitled “Twigs and Branches - Tube Formation and Branching in the Cardiovascular System", Berlin (Germany), 3-6 September, 1998.
89. Pepper M.S. Angiogenesis and mechanisms of vesselwall assembly. Proceedings of the 5th International Local Drug Delivery meeting and cardiovascular course on Radiation and molecular strategies, Geneva, Switzerland. 31 January - 2 February, 1999.
90. Gabbiani G., Pepper M.S. and Bochaton-Piallat M.-L. Molecular and cellular mechanisms: plasminogen activator expression in rat arterial smooth muscle cells depends on their phenotype and is modulated by cytokines. Proceedings of the 5th International Local Drug Delivery meeting and cardiovascular course on Radiation and molecular strategies, Geneva, Switzerland. 31 January - 2 February, 1999.
91. Quinodoz P., Pittet B., Rinsch C., Aebischer P., Montandon D. and Pepper M.S. Local delivery of bFGF by encapsulated transfected C2C12 myoblasts improves skin flap survival in the rat. Proceedings of the 12th Congress of the International Confederation for Plastic, Reconstructive and Aesthetic Surgery. San Francisco, CA, U.S.A. 27 June - 2 July, 1999.
92. Quinodoz P., Pittet B., Pepper M.S., Rinsch C., Aebischer P. and Montandon D. Local delivery of bFGF nd by encapsulated transfected C2C12 myoblasts improves skin flap survival in the rat. Proceedings of the 2 European appointed 35th National Congress of the Swiss Society of Plastic Surgery under the patronage of ESPRAS. St. Gallen, Switzerland. 2-4 September, 1999.
93. Alizadeh N., Pepper M. and Pittet B. Skin flap ischemia: a morphological and physiological study in the rat. Proceedings of the 2nd European appointed 35th National Congress of the Swiss Society of Plastic Surgery under the patronage of ESPRAS. St. Gallen, Switzerland. 2-4 September, 1999.
94. Tacchini-Cottier F., Ody C., Sabapathy K., Belin D., Wagner E.F. and Pepper M.S. The PA/plasmin system in PymT-induced vascular tumor formation. Les Diablerets, Switzerland. 4-9 September, 1999.
95. Alizadeh N., Pepper M.S., Montandon D., Bochaton-Piallat M.L., Gabbiani G., and Pittet B. L‟impact de l‟ischémie sur la cicatrisation. Proceedings of the Journée des jeunes plasticiens of the Société Francaise de Chirurgie Plastique Réconstructrice et Esthétique. Paris, France. 20 January, 2001.
96. Alizadeh N., Pittet B., Pyke C., Montandon D., Ezban M., and Pepper M.S. Le FVIIai améliore la survie des lambeaux cutanés. Proceedings of the Journée des jeunes plasticiens of the Société Francaise de Chirurgie Plastique Réconstructrice et Esthétique. Paris, France. 20 January, 2001.
97. Pepper M.S. Cytokine regulation of vascular tree formation. Proceedings of the 7th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva, Switzerland. 25-27 January, 2001.
98. Mandriota S.J., Jussila L., Jeltsch M., Compagni A., Baetens D. Prevo R., Banerji S., Huarte J., Montesano R., Jackson D., Orci L., Alitalo K., Christofori G. and Pepper M.S. VEGF-C-mediated lymphangiogenesis promotes tumour metastasis. Proceedings of the 3rd Symposium on the Biology of Endothelial Cells. Giessen, Germany. 24-26 May, 2001.
99. Alizadeh N., Pittet B., Pyke C., Baetens D., Montandon D., Ezban M. and Pepper M.S. Inactivated factor VII (FVIIai) increases viability of random skin flaps. An experimental study. Proceedings of the 12th Annual Meetng of the European Association of Plastic Surgeons. Helsinki, Finland. 31 May - 2 June, 2001.
100. Pittet B., Quinodoz P., Alizadeh N., Schlaudraff K., Montandon D. and Pepper M. How can we help acute ischemic tissue to survive? Physiopathological study of the onset of tissular necrosis in an ischemic falp - 75 - model in the rat. Proceedings of the 37ème Congrès Annuel de la Société Suisse de Chirurgie Plastique, Reconstructive et Esthétique. Geneva, Switzerland. 7-8 September, 2001.
101. Schlaudraff K., Pepper M., Ehrenburg I.O., Tkatchouk E.O., Montandon D. and Pittet B. Improvement of the survival of ischemic dorsal skin flaps in the rat by means of normobaric intermittent hypoxia training. Proceedings of the 37ème Congrès Annuel de la Société Suisse de Chirurgie Plastique, Reconstructive et Esthétique. Geneva, Switzerland. 7-8 September, 2001.
102. Alizadeh N., Pepper M.S., Montandon D., Bochaton-Piallat M.L., Gabbiani G. and Pittet B. Impact of persistent lower limb ischemia on wound healing. Proceedings of the 37ème Congrès Annuel de la Société Suisse de Chirurgie Plastique, Reconstructive et Esthétique. Geneva, Switzerland. 7-8 September, 2001.
103. Alizadeh N., Pepper M.S., Montandon D., Bochaton-Piallat M.L., Gabbiani G. and Pittet B. Impact of persistent lower limb ischemia on wound healing. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001.
104. Pittet B., Rinsch C., Quinodoz P., Baetens D., Alizadeh N., Schlaudraff K.U., Montandon D., Aebischer P. and Pepper M.S. Tissue necrosis and its modulation by local release of cytokines in a rat ischemic skin flap model. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001.
105. Schlaudraff K.U., Pepper M.S., Montandon D. and Pittet B. Normobaric intermittent hypoxia training increases the survival of ischemic random dorsal skin flaps in the rat. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001.
106. Alizadeh N., Pittet B., Pyke C., Baetens D, Montandon D., Ezban M. and Pepper M.S. Active-site inactivated FVIIa (FVIIai) increases survival in a rat ischemic skin flap model. Proceedings of the 5th Annual Meeting of the European Conference of Scientists and Plastic Surgeons. Helsinki, Finland, 28-29 September, 2001.
107. Pepper M.S. and Wernert N. VEGF-C-mediated lymphangiogenesis promotes tumor metastasis. Proceedings of the PALM AG MicroLaser Systems workshop on laser microdissection technology. Bernried, Germany, 15-16 November, 2001.
108. Pepper M.S. Angiogenesis and vessel wall assembly. Proceedings of the 8th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva, Switzerland, 31 January – 2 February, 2002.
109. Pepper M.S. Cell-based delivery of angiogenic growth factors. Proceedings of the 8th International Local Drug Delivery Meeting and Cardiovascular Course on Radiation and Molecular Strategies. Geneva, Switzerland, 31 January - 2 February, 2002.
110. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the meeting on Angiogenesis: basic mechanisms and therapeutic implications. Monte Verita (Ascona), Switzerland, 2-7 June, 2002.
111. Pepper M.S. Lymphangiogenesis and tumour metastasis. Proceedings of the Novartis Foundation (prev. Ciba Foundation) Symposium no. 256 on Inflammation and Cancer. London, U.K., 11-14 November, 2002.
112. Schlaudraff K.U., Pepper M., Ehrenburg I., Tkatchouk E., Montandon D. and Pittet B. Intracutaneous oxygen concentration in normal and ischemic skin is increased after intermittent hypoxia training. Proceedings of the 13th International Hypoxia Symposium. Banff Mountain Centre, Banff, Alberta, Canada, 19-22 February, 2003.
113. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the 35th Annual Meeting of the Swiss Societies for Experimental Biology. Davos, Switzerland, 19-21 March, 2003. - 76 -
114. Bochaton-Piallat M.L., Hao H., Verin V., Camenzind E., Pepper M.S., Gabbiani G. Porcine coronary artery smooth muscle cells are phenotypoically heterogenous. Proceedings of the 4th Annual AHA Conference on Atherosclerosis, Thrombosis and Vascular Biology. Washington DC, USA, 8-10 May, 2003.
115. Schlaudraff K.-U., Pepper M., Ehrenburg I.V., Tkatchouk E.N., Montandon D., Pittet B. Impact of intermittent hypoxia training on intracutaneous oxygen concentration in normal and ischemic skin. Proceedings of the 5th International conference on “Hypoxia in Medicine”. Innsbruck, Austria, 26-28 September 2003.
116. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the 2nd Institut Pasteur Euroconference on Angiogenesis. Paris, France, 19-20 June, 2003.
117. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the International Meeting on Angiogenesis in Cancer. Reykjavik, Iceland, 26-28 June, 2003.
118. Podograbinska S., Braun P., Velasco P., Kloos B., Pepper M.S. and Skobe M. Molecular characterization of lymphatic endothelial cells. Proceedings of the International Meeting on Angiogenesis in Cancer. Reykjavik, Iceland, 26-28 June, 2003.
119. Schlaudraff K.U., Pepper M., Ehrenburg I.V., Tkatchouk E.N., Montandon D., Pittet B. Modulation of intracutaneous oxygen concentration by intermittent hypoxia training : implications for flap survival. Proceedings of the 7th European Conference of Scientists and Plastic Surgeons. Geneva, Switzerland, 19- 20 September, 2003.
120. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the 69. Jahresversammlung Schweizerische Gesellschaft für Pathologie. Ittingen, Switzerland, 6-8 November, 2003.
121. Pepper M.S. Métastases lymphogènes des tumeurs digestives. Proceedings of the Journées medico- chirurgicales d‟hépatologie et de gastroenterologie. Geneva, Switzerland, 27-28 November, 2003.
122. Mahajan A.L., Tenorio X., Schlaudraff K.U., Pepper M.S., Baetens D., Montandon D. and Pittet B. New therapeutic intervention with rNAPc2 curbs progression of the burn wound. Poceedings of the XXIXth Sir Peter Freyer Meeting, Galway, Ireland. 3 September, 2004.
123. Pepper M.S. Genes guide the way - a promise of new technology. Proceedings of the Roche In Vitro Diagnostics Forum. Johannesburg (South Africa). 4 October, 2004.
124. Pepper M.S. Lymphangiogenesis and tumor metastasis. Proceedings of the Autumn meeting of the Belgian Society for Cell and Developmental Biology. Liège (Belgium). 16 October, 2004.
125. Henrichot E., Juge-Aubry C.E., Nisato R., Wohlwend A., Pernin A., Velebit V., Pepper M.S., Meda P. and Meier C.A. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Proceedings of the Société Suisse d'Endocrinologie et Diabétologie, Bern, Switzerland. November 2004.
126. Alizadeh N., Pepper M.S., Alfo K., Montandon D., Gabbiani G., Bochaton-Piallat M.-L. and Pittet B. Persistent ischemia impairs myofibroblast development in wound granulation tissue. A new model of delayed wound healing. Switzerland. November 2004.
127. Tenorio X., Schlaudraff K.-U., Pittet B., Baetens D. and Pepper M.S. Application of rNAPc2 reduces secondary aggravation of burn wounds. Proceedings of the 49th Congrés nationale de la société francaise de chirurgie plastique reconstructice et esthétique. Paris, France. 22-24 November, 2004.
- 77 - 128. Tenorio X., Schlaudraff K.-U., Pittet B., Baetens D. and Pepper M.S. Application of rNAPc2 reduces secondary aggravation of burn wounds. 41ème Congrès annuel de la société suisse de chirurgie plastique, reconstructrice et esthétique. Bienne, Switzerland. 30 September - 1 October, 2004.
129. Mahajan A.L., Tenorio X., Schlaudraff K.U., Pepper M.S., Baetens D., Montandon D. and Pittet B. Progressive tissue injury in burns is reduced by rNAPc2. Poceedings of the British Association of Plastic Surgeons Meeting, London, UK. December, 2004.
130. Tenorio X, Schlaudraff K.-U., Mahajan A.L., Pepper M.S., Montandon D., Pittet P. Application of rNAPc2 reduces secondary aggravation of burn wounds. 8th European Conference of Scientists and Plastic Surgeons (ECSAPS). Munich (Germany). 15-16 October, 2004.
131. Mathe Z., Dupraz P., Zbinden M., Bosco D., Bucher P., Rinsch C., Thorens B., Berney T. and Pepper M.S. VEGF-A overexpression improves islet cell revascularization and glycemic control after transplantation. American Transplant Congress, Seattle (WA, USA). May, 2005.
132. Mahajan A.L., Schlaudraff K.U., Tenorio X., Pepper M.S., Baetens D., Montandon D. and Pittet B. Progressive tissue injury in burns is reduced by rNAPc2. Proceedings of the British Burns Association (BBA) meeting, York, UK, April 2005.
133. Pepper M.S. Genes guide the way – the promise of new technology. Proceedings of the In Vitro Diagnostics Forum, Athens (Greece), 8-10 June 2005.
134. Mabeta P., Davis P.F. and Pepper M.S.: In vitro inhibition of angiogenesis by interferon alpha and bleomycin. Nature Biotechnology Winter Symposium on Angiogenesis in Cancer and Vascular Disease. Miami Beach, Florida (USA) 4-8 February 2006.
135. Schlaudraff K.-U., Mahajan A.L., Tenorio X., Pepper M.S., Montandon D. and Pittet B. Secondary aggravation of burn wounds and its detrimental influence on post burn sequelae – an underestimated clinical phenomenon? Abstract submitted for the EURAPS-meeting 2006.
136. Pepper MS. The genetics of obesity. Proceedings of the 44th Annual Congress of the South African Gastroenterology Society. Post Elizabeth, South Africa. August 6-9, 2006.
137. Nisato R.E., Tille J.-C., Baetens D., Sutter E., Orci L., Pytowski B. and Pepper M.S. Role of VEGFRs -1, - 2 and -3 in VEGF-C-induced lymphangiogenesis and in lymphatic-mediated metastases in Rip1Tag2:Rip1VEGF-C mice. Proceedings of the Gordon Research Conference on "Molecular Mechanisms In Lymphatic Function & Disease", Les Diablerets, Switzerland. 3-8 September, 2006.
138. van der Merwe M.T., Logan M., Pieters J.H., Sammi Y. and Pepper M.S. Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. 15th European Congress on Obesity, Budapest, Hungary. April 22-25, 2007.
139. van der Merwe M.T., Logan M., Pieters J.H., Sammi Y., Pepper M.S. Sustained weight loss after an 18 month period of intensive obesity intervention and the successful use of pro-BNP to exclude cardiac disease. 42nd SEMDSA Congress. Bloemfontein, South Africa. 30 June – 2 July, 2007.
140. Hochfeld W., Asfaha S., Durandt C. and Pepper M.S. Utilization of the Roche Amplichip Platform For Pre-Prescription Genotyping. The 2007 University of Pretoria, School of Medicine, Faculty of Health Sciences Basic Sciences Research Day. Pretoria, South Africa. 15 August 2007.
141. Hochfeld W., Asfaha S., Durandt C. and Pepper M.S. Utilization of the Roche Amplichip Platform For Pre-Prescription Genotyping. The 2007 Pharmacology and Toxicology Congress, The South African Pharmacology Society (SAPS). North West Province, South Africa. 2-5 October 2007.
142. Mabeta P. Pepper M.S. The effect of Paclitaxel on neovessel formation in vitro. 35th PSSA congress, Muldersdrift, South Africa, 9-12 September 2007. - 78 -
143. Mabeta P. Pepper M.S. Induction of in vitro angiogenesis in bovine endothelial cells and the effect of Paclitaxel on neovessel formation. Faculty Day, Faculty of Veterinary Sciences, University of Pretoria, 3rd September 2007.
144. Mabeta P., Davis P.F. and Pepper M.S.: Assessment of the effects of bleomycin on human haemangioma and angiogenesis in vitro. Faculty Day, Faculty of Health Sciences, University of Pretoria, 15th August 2007.
145. Dodgen T., Hochfeld W., Asfaha S., Durandt C. and Pepper M.S. Utilization of the Roche Amplichip platform for pre-prescription genotyping. 20th Biennial South African Genetics Society (SAGS) Congress. Pretoria, 27-29 March, 2008.
146. Mabeta P. and Pepper M.S. 2-Methoxyestradiol inhibits angiogenesis in vitro. 46th Annual Conference of the Microscopy Society of Southern African. Gaborone, Botswana, 23-25 July 2008.
147. Dodgen T.M., Cromarty A.D. and Pepper M. Phenotyping of CYP450-mediated drug metabolism in a demographically representative sample of the South African population. ChromSAAMS (Chromatography and Mass Spectrometry Divisions of the South African Chemical Institute), Bela Bela, South Africa. 12-15 October 2008.
148. Pepper M.S. Stem cells: current reality and future promise. International Physiotherapy Congress. Pretoria, South Africa. 6-8 October, 2008.
149. Skeen M. and Pepper M.S. Stem cell therapy for spinal cord injury – a retrospective analysis of patients in South Africa. 7th South African Symposium on Haematopoietic Stem Cell Transplantation. Johannesburg, South Africa. 30-31 January, 2009.
150. Thompson D and Pepper M.S. Flow cytometric analysis of stem cells derived from umbilical cord blood in South Africa. 7th South African Symposium on Haematopoietic Stem Cell Transplantation. Johannesburg, South Africa. 30-31 January, 2009.
151. Flister M.J., Wilber A., Hall K.L., Iwata C., Miyazono K., Nisato R.E., Pepper M.S., Zawieja D.C and Ran S. VEGFR-3 and Prox1 are elevated by NF-kB during inflammatory angiogenesis. 100th Annual Meeting of the American Association for Cancer Research. Denver (CO), USA. 18-22 April, 2009.
152. Mabeta P. and Pepper M.S. Bleomycin inhibits angiogenesis and induces apoptosis in cultured bovine microvascular endothelial cells. 17th Conference of the International Federation of Associations of Anatomists (IFAA), Cape Town, South Africa, 16-19 August 2009.
153. Dodgen T.M, Cromarty A.D. and Pepper M.S. Pre-prescription genotyping of CYP2D6 and CYP2C19 in a demographically representative group of the South African population. Faculty Day, Faculty of Health Sciences, University of Pretoria, 19 August 2009.
154. Eloff A., van Staden C.W., Dodgen T.M., Mataboge C., Roos J.L. and Pepper M.S. Cytochrome P450 2D6 Polymorphisms in Weight Gain and Movement Disorders Associated with Risperidone: A Pilot Study. Faculty Day, Faculty of Health Sciences, University of Pretoria, 19 August 2009.
155. Dodgen T.M., Cromarty A.D., Fickl H. and Pepper M.S. Genotype vs. phenotype and the allelic variation of CYP2D6 and CYP2C19 in a demographic sample of the South African population. International Congress on Pharmaceutical and Pharmacological Sciences, North-West University, 23-26 September 2009.
156. Pepper M.S. Sustainability strategies in public cord blood banking. 31st South African National Blood Transfusion Congress, Johannesburg, 15-18 November 2009.
- 79 - 157. Mabeta P., Sosibo N., Tshikhudo R. and Pepper M.S. Nanoparticle-based chemotherapy inhibits tumour- associated angiogenesis in a murine vascular tumour model. International Conference on Drug Discovery and Therapy, Dubai, UAE. February 1st - 4th, 2010.
158. Skeen M., Eksteen C. and Pepper M.S. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. Neuroscience Day, University of Pretoria, South Africa. 26 May 2010.
159. Potgieter M., Pretorius R. and Pepper M.S. The effect of antioxidant supplementation in dysferlin- deficient muscular dystrophy mice. Neuroscience Day, University of Pretoria, South Africa. 26 May 2010.
160. Skeen M., Eksteen C. and Pepper M.S. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. 49th International Spinal Cord Society (ISCoS) Meeting, New Delhi, India. 29-31 October 2010.
161. Alessandrini M., Dodgen T., Asfaha S. and Pepper M. Genetic and phenotypic variation of CYP450 enzymes in African populations. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010.
162. Dodgen T.M., Drögemöller B.I., Wright G.E.B, Warnich L., Cromarty A.D and Pepper M.S. Pharmacogenetics of CYP2C19 for personalizing medication in the South African population. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010.
163. Potgieter M., Pretorius E., Beukes M. and Pepper M. The effect of antioxidant supplementation in dysferlin-deficient muscular dystrophy mice. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010.
164. Skeen M.C., Eksteen C. and Pepper M. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. Faculty Day, Faculty of Health Sciences, University of Pretoria, 18 August 2010.
165. Myburgh R., Salmon P., Sorce S., Hirschel B., Pepper M.S. and Krause K.-H. HIV gene therapy by CCR5 knockdown using multiple short hairpin RNAs. 4ème journée de l'innovation, Hôpitaux universitaires de Genève. Geneva (Switzerland), 13 October 2010.
166. Alessandrini M., Asfaha S.M., Dodgen T.M., Warnich L. and Pepper M.S. Genotypic and Phenotypic Variability Related to CYP450 Metabolism in African Populations. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.
167. Dodgen T.M., Drögemöller B.I., Wright G.E.B, Warnich L., Fickl H., Steffens F.E., Cromarty A.D and Pepper M.S. Evaluation of CYP2C19 genotype and phenotype in a representative sample of the South African population. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.
168. Dodgen T.M., Labuschagne C.D.J, van Schalkwyk A., Fickl H., Cromarty A.D. and Pepper M.S. Evaluation of CYP2D6 genotype and phenotype in a representative sample of the South African population. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.
169. Dodgen T.M., Eloff A., Mataboge C., Roos J.L., van Staden C.W., Pepper M.S. Risperidone-associated adverse drug reactions and Cytochrome P450 2D6 polymorphisms: a pilot study Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011.
170. Logan M.G., van der Merwe M-T., Myburg R., Eloff A., Rheeder P. and Pepper M.S. Melanocortin 4 receptor (MC4R) polymorphisms in a South African study group. Joint International Conference of the African and Southern African Societies of Human Genetics, Cape Town, 6-9 March 2011. - 80 -
171. Barmania F., Potgieter M. and Pepper MS. Analysis of CCR5 expressing CD4 cells and mutations in the CCR5 gene in African and Caucasian South African population groups. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011.
172. Potgieter M., van Vollenstee F., Kallmeyer K., Dessels C., Jackson C. and Pepper M.S. Human mesenchymal stem cells: isolation, characterization and differentiation. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011.
173. Rangaka I., Alessandrini M. and Pepper M.S. Economic feasibility for establishing a public cord blood stem cell bank in South Africa. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011.
174. Meissner-Roloff M., Young W., Mellet J., Rangaka I. and Pepper M.S. Establishing a public human umbilical cord blood stem cell bank – a pilot study. Faculty Day, Faculty of Health Sciences, University of Pretoria, 31 August 2011.
175. Mabeta P. and Pepper M.S. Suppression of Akt activity and bcl-2 expression is associated with the inhibition of hemangiomagenesis. International Symposium on Anti-Angiogenic Therapy. San Diego, CA, February 2, 2012.
176. van Vollenstee F., Jackson C., Hoffmann D., Kallmeyer K., Potgieter M., Durant C. and Pepper M.S. The optimization of GFP positive lentiviral vectors and assessment of the characteristics of transduced mesenchymal stem cells. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
177. Rangaka I., Alessandrini M. and Pepper, M.S. Operational model and cost implications for establishing a public cord blood stem cell bank in South Africa. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
178. Van Rensburg J., Alessandrini M. and Pepper M. Exploring the accuracy of mutation frequency data for monogenic disorders: the use of metachromatic leukodystrophy as a case and point. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
179. Meissner-Roloff M. and Pepper M.S. Establishing a public umbilical cord blood stem cell bank for South Africa: Social feasibility. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
180. Alessandrini M., Klose K. and Pepper M.S. University entrepreneurship in South Africa: results from a national survey of technology transfer practices. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
181. Potgieter M., Durandt C., De Villiers D. and Pepper M.S. The effect of light activation on mesenchymal stem cell phenotype. Faculty Day, Faculty of Health Sciences, University of Pretoria, 28-29 August 2012.
182. Skeen M., Eksteen C. and Pepper M.S. A retrospective analysis of the perceived outcome of stem cell therapy for persons living with a spinal cord injury. 52nd Annual Meeting of the International Spinal Cord Society, Istanbul, 28-30 October, 2013.
183. De Bruyn K., Potgieter M., De Villiers P. and Pepper M.S. A theoretical probabilistic approach to mesenchymal stem cell proliferation modelling. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
184. De Villiers D., Potgieter M., Durandt C. and Pepper M.S. The effect of hydrogen peroxide on the adipogenic differentiation potential of mesenchymal stem cells. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
- 81 - 185. Stewart C., van Rensburg J., Alessandrini M., Masekela R., Green R. and Pepper M.S. Minding the gap – addressing the lack of South African cystic fibrosis patient data. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
186. Mellet J., Gray C. and Pepper M.S. HLA typing: conventional techniques vs. next generation sequencing.
187. Durandt C., van Vollenstee F., Kallmeyer K., de Villiers D., Honing C., Potgieter M. and Pepper M.S. Novel flow cytometric approach for the detection of adipocyte sub-populations during adipogenesis. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
188. Potgieter M., Alessandrini M. and Pepper M.S. Mesenchymal stem cells: the clinical trial landscape. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
189. Van Vollenstee F., Gaggia L., Hoffman D., Kallmeyer K., Potgieter M., Coetzee P., Vermeulen M. and Pepper M.S. Evaluation of the PROCLEIX ULTRIO Plus assay for the detection of HIV-1 in umbilical cord- and adipose tissue derived mesenchymal stem cells. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
190. Kallmeyer K., van Vollenstee F., Potgieter M. and Pepper M.S. Isolation and characterization of mesenchymal stem cells from human tissues. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
191. Alessandrini. M., Beltchev. E., Pool. R. and Pepper M.S. Diagnosis of acute myeloid leukaemia in south Africa by means of microarray technology. Faculty Day, Faculty of Health Sciences, University of Pretoria, 20-21 August 2013.
192. Alessandrini M. and Pepper M.S. Defining the need for pharmacogenetic profiling in Africa: A perspective on cytochrome P450. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013.
193. Alessandrini M., Beltchev E., Pool R. and Pepper M.S. AMLprofiler: Evaluation of a novel diagnostic for acute myeloid leukaemia in the South African setting. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013.
194. Alessandrini M., Beltchev E., Pool R. and Pepper M.S. AMLprofiler: Evaluation of a novel diagnostic microarray for acute myeloid leukaemia in the South African setting. Young Researchers Forum, University of the Witwatersrand, South Africa, 5 October 2013.10.19.
195. Mellet, J., Gray C.M. and Pepper M.S. HLA typing: conventional techniques versus next generation sequencing. Young Researchers Forum, University of the Witwatersrand, South Africa, 5 October 2013.
196. Mellet, J., Gray C.M. and Pepper M.S. HLA typing: conventional techniques versus next generation sequencing. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013.
197. Stewart. C., van Rensburg. J., Alessandrini. M., Masekela. R., Green. R. and Pepper M.S. The requirement for a population-specific diagnostic tool for CF in South Africa. Young Researchers Forum, University of the Witwatersrand, South Africa, 5 October 2013.
198. Stewart. C., van Rensburg. J., Alessandrini. M., Masekela. R., Green. R. and Pepper M.S. The requirement for a population-specific diagnostic tool for CF in South Africa. 15th Biennial Congress of the Southern African Society of Human Genetics, The Maslow, Sandton, South Africa, 6-9 October 2013.
199. Alessandrini M. and Pepper M.S. Priority Pharmacogenetics for the African continent: a view on cytochrome P450. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
- 82 - 200. Van Rensburg J., Alessandrini M. and Pepper M.S. Determining the accuracy of mutation diversity measurements in metachromatic leukodystrophy. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
201. Stewart C., Van Rensburg J., Alessandrini M., Masekela R., Green R. and Pepper M.S. The requirement for a population-specific diagnostic tool for CF in South Africa. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
202. Mellet J., Gray C.M. and Pepper M.S. HLA typing: Conventional techniques versus next generation sequencing. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
203. Alessandrini M., Beltchev E., Pool R. and Pepper MS. Implementation of the AMLprofiler microarray for the diagnosis and prognosis of acute myeloid leukaemia in South Africa. Seminar Day, Genomics Research Institute, University of Pretoria, 14 November 2013.
204. Pepper MS. The human genome. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus, Kingston , Jamaica, 22 November 2013.
205. Pepper MS. Stem cells – current reality and future promise. 2nd Annual Conference, Society for Scientific Advancement: Therapeutic and Functional Genomics, University of the West Indes, Mona Campus, Kingston , Jamaica, 22 November 2013.
206. Durandt C., van Vollenstee F.A., Dessels C., Kallmeyer K., Potgieter M., de Villiers D., Honing C., and Pepper M.S. Novel flow cytometric approach for the detection of adipocyte sub-populations during adipogenesis. XXIX Congress of the International Society for Advancement of Cytometry. Ft Lauderdale, Florida, USA. 17-21 May 2014.
207. Alessandrini M and Pepper M.S. Establishing a public umbilical cord blood stem cell bank for South Africa: an enquiry into public acceptability. 4th Ethics, Human Rights and Medical Law conference at the Africa Health Congress. Gallagher Convention Center. 29 May 2014
208. Van Wyk J., Pepper M.S., van der Walt I. and Honing C. Shepherding data on the way to long term stewardship: Research Data Management at the University of Pretoria: a case study. 12th Southern African Online Information Meeting (SAOIM), June 2014.
209. Kallmeyer K., Van Vollenstee F.A., Durandt C., Potgieter M. and Pepper M.S. Isolation and characterization of mesenchymal stem cells from human tissues.17th World Congress of Basic & Clinical Pharmacology, Cape Town, 13-18 July 2014.
210. Alessandrini M. and Pepper M.S. Priority pharmacogenetics for Africa: establishment of a pan-African initiative. 17th World Congress of Basic and Clinical Pharmacology (WCP2014), Cape Town, South Africa, 13-18 Jul 2014.
211. Dessels C., Alessandrini M. and Pepper M.S. Umbilical Cord Blood Banks: A Perspective. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
212. Jackson C.S., Durandt C., Praloran V., Brunet de la Grange P., and Pepper M.S. Targeting The ARNT Complex With DMOG And Stemregenin 1 Improves the Expansion of Primitive Hematopoietic Cells. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
213. Stewart C., van Rensburg J., Alessandrini M., Masekela R., Green R., Zampoli M., Kerbelker T. and Pepper M.S. Towards A South African Cystic Fibrosis Patient Registry. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
- 83 - 214. Kiper I., Dessels C., Pepper M.S. and Durandt C. Comparasion Of Nile Red And Bodipy 493/503 Staining On Quantification Of Lipid Content Of Adipocytes Using Fluorescence Microscopy. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
215. Van Rensburg, J., Alessandrini, M. and Pepper, M.S. Rarefaction and Metachromatic Leukodystrophy: A Unifying Factor in Medical Genetics and Ecological Disciplines. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
216. Theron A.E., Lafanechère L., Pepper M.S., Prudent R., Viallet J., Jackson C., Durandt C. and Joubert A.M. Novel Sulphamiolated Analogues Exhibit Promising In Vitro and In Ovo Anti-Cancer Properties. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
217. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
218. De Bruin K.J.F., Dessels C., De Villiers J.P. and Pepper M.S. Estimation of Cell Counts and Confluency of Adherent Adipose-Derived Stem Cells Using Unstained Phase-Contrast Micrographs. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
219. Kallmeyer K., van Vollenstee F.A., Durandt C., Potgieter M. and Pepper M.S. Differences in Basic Biological Characteristics Exist Between Adipose- and Wharton‟s Jelly-Derived Mesenchymal Stromal Cells. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
220. Alessandrini M., Potgieter M. and Pepper M.S. Mesenchymal Stem Cell Therapy: Overview of Clinical Indications. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
221. Kappala S.S., Alessandrini M., Beltchev E., Matlahko T., Pool R. and Pepper M.S. Evaluation of AMLprofiler Compared to the Standard Diagnostic Procedures in Patients with Acute Myeloid Leukemia. Faculty Day, Health Sciences, University of Pretoria, 19-20 August 2014.
222. Dessels C., Alessandrini M. and Pepper M.S. Umbilical Cord Blood Banks: A Perspective. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
223. Jackson C.S., Durandt C., Praloran V., Brunet de la Grange P., and Pepper M.S. Targeting The ARNT Complex With DMOG And Stemregenin 1 Improves the Expansion of Primitive Hematopoietic Cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technolgy, Pretoria. 27-31 August 2014.
224. Durandt C., van Vollenstee A., Dessels C., Kallmeyer K., Kiper I., de Villiers D., Honing C., Potgieter M., Hoffman D. and Pepper M.S. A multi-colour flow cytometry approach to quantify various stages during adipocyte differentiation: Comparison between Nile Red & Bodipy 493/503. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
225. De Villiers D., Potgieter M., Durandt C. and Pepper M.S. The effect of induced oxidative stress and antioxidant supplementation on the adipogenic differentiation potential of adipose-derived mesenchymal stem cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
226. Van Vollenstee F.A., Jackson C., Hoffmann D., Kallmeyer K., Potgieter M., Durandt C. and Pepper M.S. Immunophenotypical characterisation and differentiation capacity of transduced human adipose derived mesenchymal stromal cells by optimized GFP positive lentiviral vectors International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
- 84 - 227. Van Vollenstee F.A., Gaggia L., Hoffmann D., Kallmeyer K., Potgieter M., Coetzee P.F., Vermeulen M. and Pepper M.S. Establishment of a useful molecular platform to for the detection of HIV-1 in umbilical cord- and adipose tissue-derived mesenchymal stem cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
228. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
229. Mellet J. and Pepper M.S. Constituting a public umbilical cord blood bank in South Africa: Demographics, linguistics, and HLA diversity. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
230. De Bruin K.J.F., Dessels C., De Villiers J.P. and Pepper M.S. Estimation of Cell Counts and Confluency of Adherent Adipose-Derived Stem Cells Using Unstained Phase-Contrast Micrographs. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
231. Kallmeyer K. , van Vollenstee F.A., Durandt C., Potgieter M. and Pepper M.S. Differences in Basic Biological Characteristics Exist Between Adipose- and Wharton‟s Jelly-Derived Mesenchymal Stromal Cells. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
232. McGillewie L., Jackson C., Pepper M.S. and Durandt C. Does multi-colour flow cytometry allow for the identification of primitive cord blood-derived hematopoietic stem cells, using only surface marker staining? International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
233. Alessandrini M., Potgieter M. and Pepper M.S. Clinical indications for mesenchymal stem cell therapy. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
234. Alessandrini M. and Pepper M.S. Establishment of a sustainable public cord blood stem cell bank for South Africa. International Conference on Tissue Engineering and Regenerative Medicine. Tshwane University of Technology, Pretoria. 27-31 August 2014.
235. Alessandrini M., Krause K-H., Speck R.F., Salman P., Myburg R. and Pepper M.S. Clinical Translation of an HIV Gene Therapy. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland.
236. Myburgh R., Pepper M.S., Speck R.F., Krause K-H. and Salmon P. Improved knockdown of target genes via miRNA. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland.
237. Myburgh R., Pepper M.S., Salman P., Krause K-H. and Speck R.F. Gene engineering an HIV resistant immune system. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland.
238. Speck R., Hirschel B., Krause K-H., Salmon P., Myburgh R. and Pepper M. TGT: cure HIV through engineering of an HIV-resistant immune system. World Innovation Day “Innovation for Health Competition” – August 28‐29, 2014 – Geneva, Switzerland.
239. Mabeta P., Davis P.F. and Pepper M.S. Vascular specific growth factors in angiogenesis: signaling pathways and therapeutic targeting. 42nd Annual Conference of the Physiology Society of Southern Africa, Durban, South Africa, 14-17 Sept 2014.
- 85 - 240. Kappala S., Alessandrini M., Beltchev E., Matlahko T., Pool R. and Pepper M.S. AMLprofiler: A novel diagnostic tool for patients with acute myeloid leukemia in South Africa. UNIPATH 2014 (Unifying Pathology and Laboratory Medicine in the Era of P4 Medicine), CSIR International Convention Centre, Pretoria, South Africa, 19-21 Sept 2014.
241. Durandt C. and Pepper M.S. Adipose Tissue As An Immunological Active Organ. UNIPATH. CSIR, Pretoria. 19-21 September 2014.
242. Alessandrini M., Kappala S.S., Beltchev E., Matlahko T., Pool R. and Pepper M.S. Diagnostic nd Prognostic Value of AMLprofiler in the South African Context. UNIPATH. CSIR, Pretoria. 19-21 September 2014.
243. Kappala S.S., Alessandrini M., Beltchev E., Matlahko T., Pool R. and Pepper M.S. Evaluation of AMLprofiler Compared to the Standard Diagnostic Procedures in Patients with Acute Myeloid Leukemia. UNIPATH. CSIR, Pretoria. 19-21 September 2014.
244. Jackson C.S. and Pepper M.S. Analyzing techniques to improve the transduction of HSCs. South African Genetics Society Congress. 23-26 September 2014.
245. Alessandrini M., Kappala S., Matlahko T., Beltchev E., Pool R. and Pepper M.S. AMLprofiler. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.
246. Colic A., Alessandrini M. and Pepper M.S. Pharmacogenetics of CYP2B6, CYP2A6, and UGT2B7 in HIV treatment in African populations. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.
247. Jackson C.S., Durandt C, de la Grange P.B., Praloran V. and Pepper M.S. Improving the expansion and transduction of primitive hematopoietic stem cells. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.
248. Stewart C., van Rensburg J., Zampoli M., Kerbelker T., Masekela R., Green R. and Pepper M.S. In the blood – Identifying cystic fibrosis mutations in South African patients. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.
249. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Genomics Research Institute (GRI) Seminar Day, University of Pretoria, 31 Oct 2014.
250. Theron A.E., Lafanechère L., Pepper M.S., Prudent R., Viallet J., Jackson C., Durandt C, and Joubert A.M. Novel in silico-designed anti-cancer compounds: from in vitro exploration to potential clinical considerations. 4th World Congress on Cancer Science & Therapy, October 2014.
251. Alessandrini M. and Pepper M.S. Establishment of a public cord blood stem cell bank for South Africa. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014. 252. Dessels C., Alessandrini M. and Pepper M.S. The treatment landscape of umbilical cord blood banks. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
253. Jackson C.S., Durandt C., Brunet de la Grange P., Praloran V. and Pepper M.S. Targeting the HIF complex with DMOG and stemregenin 1 mediates the improved expansion of primitive hematopoietic cells. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
254. Jackson C.S. and Pepper M.S. Improving lentivirus transduction of primitive HSCs. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
- 86 - 255. Mellet J., Gray C.M. and Pepper M.S. Conventional HLA Typing Techniques vs. Next Generation Sequencing in a South African Cohort. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
256. Mellet J. and Pepper M.S. Constituting a public umbilical cord blood bank in South Africa: Demographics, linguistics, and HLA diversity. Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.
257. Alessandrini M. and Pepper M.S. Establishment of a public cord blood stem cell bank for South Africa Worldwide Network for Blood & Marrow Transplantation (WBMT), Cape Town, South Africa, 14-16 Nov 2014.