COHERENCE In-Vitro.Pdf
International Journal of Antimicrobial Agents 57 (2021) 106344 Contents lists available at ScienceDirect International Journal of Antimicrobial Agents journal homepage: www.elsevier.com/locate/ijantimicag Review Systematic review and meta-analysis of in vitro efficacy of antibiotic combination therapy against carbapenem-resistant Gram-negative bacilli ∗ Luigia Scudeller a,1, Elda Righi b,1, , Margherita Chiamenti b, Damiano Bragantini b, Giulia Menchinelli c,d, Paolo Cattaneo b, Christian G. Giske e, Thomas Lodise f, Maurizio Sanguinetti c,d, Laura J.V. Piddock g, François Franceschi g, Sally Ellis g, ∗ Elena Carrara b, Alessia Savoldi b, Evelina Tacconelli b,h,i, a Clinical Epidemiology and Biostatistics, IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano Foundation, Milan, Italy b Division of Infectious Diseases, Department of Diagnostic and Public Health, University of Verona, P.Le L.A. Scuro 10, 37134 Verona, Italy c Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy d Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy e Clinical Microbiology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden f Albany College of Pharmacy and Health Sciences, Albany, New York, USA g Global Antibiotic Research & Development Partnership (GARDP), 15 Chemin Louis-Dunant, Geneva, Switzerland h Division of Infectious Diseases, Department of Internal Medicine I, German Center for Infection Research, University of Tübingen, Otfried Müller Straße 12, 72074 Tübingen, Germany i German Centre for Infection Research (DZIF), Clinical Research Unit for Healthcare Associated Infections, Tübingen, Germany a r t i c l e i n f o a b s t r a c t Article history: The superiority of combination therapy for carbapenem-resistant Gram-negative bacilli (CR-GNB) in- Received 20 January 2021 fections remains controversial.
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