Anti-PDCD1LG2 Monoclonal Antibody, Clone MIH14 [R-PE] (CABT-51704MH) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-PDCD1LG2 monoclonal antibody, clone MIH14 [R-PE] (CABT-51704MH) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse anti Human CD273 antibody, clone MIH14 detects human CD273, also known as B7-DC and Programmed Death Ligand 2 (PD-L2). CD273 is a 42kD member of the immunoglobulin receptor superfamily, and is a ligand for CD279 (PD-1). CD273 is primarily expressed on dendritic cells, and its expression can be induced on inflammatory macrophages when activated by interleukin 4 or Th2 cells. CD273 functions to inhibit T-cell proliferation by blocking cell cycle progression and cytokine production, and is particularly important in the maintenance of self tolerance. Flow Cytometry Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.

Specificity PDCD1LG2

Immunogen Human B7-DC transfected L cells.

Isotype IgG1

Source/Host Mouse

Species Reactivity Human

Clone MIH14

Conjugate R-PE

Applications FC

Procedure Conjugated Antibodies

Format Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised

Size 100 Tests

Preservative 0.09% Sodium Azide

Storage Store at +4°C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Warnings For research purposes only

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name PDCD1LG2 programmed cell death 1 ligand 2 [ Homo sapiens (human) ]

Official Symbol PDCD1LG2

Synonyms PDCD1LG2; programmed cell death 1 ligand 2; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2; B7 dendritic cell molecule;

Entrez Gene ID 80380

Protein Refseq NP_079515

UniProt ID Q9BQ51

Chromosome Location 9p24.2

Pathway Adaptive Immune System; Cell adhesion molecules (CAMs); Costimulation by the CD28 family; Immune System; PD-1 signaling;

Function molecular_function;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]