bioRxiv preprint doi: https://doi.org/10.1101/2021.08.25.456776; this version posted August 27, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The indoleamine 2,3 dioxygenase pathway drives intratumoral B cell maintenance. by Burles A. Johnson III1,2,3, Adam K. Aragaki2, Donna M. Williams3, Ophelia Rogers3, Jack Mountain2, Li Luo3, Wenhao Zhang3, Lingling Xian3, Mingxiao Feng2, Lionel Chia3, Dominic Dordai4, Noah M. Hahn1,2, Stephen Desiderio4, Theodore S. Johnson5, David J. McConkey2, and Linda M.S. Resar1,3,6. 1Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2Johns Hopkins Greenberg Bladder Cancer Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Park 219, Baltimore, MD 21287 3Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Room 1025, Baltimore, MD 21205 4Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205 5Georgia Cancer Center and Department of Pediatrics, Augusta University, 1120 15th Street, Augusta, GA 30912 6Department of Pathology and Institute for Cellular Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205 Abstract: 219 words; Manuscript Text: 4929 words Correspondence:
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[email protected] Abbreviations: IDO1, indoleamine 2,3 dioxygenase-1; Bregs, regulatory B cells, Tregs, regulatory T cells; LLC, Lewis Lung Carcinoma; PD-1/L, programmed cell death protein-1/ligand; APCs, antigen presenting cells; MDSCs, myeloid derived suppressor cells; IL, interleukin. bioRxiv preprint doi: https://doi.org/10.1101/2021.08.25.456776; this version posted August 27, 2021.