Anti-PDCD1LG2 monoclonal antibody, clone MIH14 [R-PE] (CABT-51704MH) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse anti Human CD273 antibody, clone MIH14 detects human CD273, also known as B7-DC and Programmed Death Ligand 2 (PD-L2). CD273 is a 42kD member of the immunoglobulin receptor superfamily, and is a ligand for CD279 (PD-1). CD273 is primarily expressed on dendritic cells, and its expression can be induced on inflammatory macrophages when activated by interleukin 4 or Th2 cells. CD273 functions to inhibit T-cell proliferation by blocking cell cycle progression and cytokine production, and is particularly important in the maintenance of self tolerance. Flow Cytometry Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Specificity PDCD1LG2 Immunogen Human B7-DC transfected L cells. Isotype IgG1 Source/Host Mouse Species Reactivity Human Clone MIH14 Conjugate R-PE Applications FC Procedure Conjugated Antibodies Format Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised Size 100 Tests Preservative 0.09% Sodium Azide Storage Store at +4°C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. Warnings For research purposes only 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Gene Name PDCD1LG2 programmed cell death 1 ligand 2 [ Homo sapiens (human) ] Official Symbol PDCD1LG2 Synonyms PDCD1LG2; programmed cell death 1 ligand 2; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2; B7 dendritic cell molecule; Entrez Gene ID 80380 Protein Refseq NP_079515 UniProt ID Q9BQ51 Chromosome Location 9p24.2 Pathway Adaptive Immune System; Cell adhesion molecules (CAMs); Costimulation by the CD28 family; Immune System; PD-1 signaling; Function molecular_function; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.