Journal of Medicinal Plants Research
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OPEN ACCESS Journal of Medicinal Plants Research 10 November 2018 ISSN 1996-0875 DOI: 10.5897/JMPR www.academicjournals.org ABOUT JMPR The Journal of Medicinal Plant Research is published twice monthly (one volume per year) by Academic Journals. The Journal of Medicinal Plants Research (JMPR) is an open access journal that provides rapid publication (twice monthly) of articles in all areas of Medicinal Plants research, Ethnopharmacology, Fitoterapia, Phytomedicine etc. The Journal welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published shortly after acceptance. All articles published in JMPR are peer reviewed. Electronic submission of manuscripts is strongly encouraged, provided that the text, tables, and figures are included in a single Microsoft Word file (preferably in Arial font). Contact Us Editorial Office: [email protected] Help Desk: [email protected] Website: http://www.academicjournals.org/journal/JMPR Submit manuscript online http://ms.academicjournals.me/ Editors Prof. Akah Peter Achunike Prof. Parveen Bansal Editor-in-chief Department of Biochemistry Department of Pharmacology & Toxicology Postgraduate Institute of Medical Education and University of Nigeria, Nsukka Research Nigeria Chandigarh India. Associate Editors Dr. Ravichandran Veerasamy AIMST University Dr. Ugur Cakilcioglu Faculty of Pharmacy, AIMST University, Semeling - Elazıg Directorate of National Education 08100, Turkey. Kedah, Malaysia. Dr. Jianxin Chen Dr. Sayeed Ahmad Information Center, Herbal Medicine Laboratory, Department of Beijing University of Chinese Medicine, Pharmacognosy and Phytochemistry, Beijing, China Faculty of Pharmacy, Jamia Hamdard (Hamdard 100029, University), Hamdard Nagar, New Delhi, 110062, China. India. Dr. Hassan Sher Dr. Cheng Tan Department of Botany and Microbiology, Department of Dermatology, first Affiliated Hospital College of Science, of Nanjing Univeristy of King Saud University, Riyadh Traditional Chinese Medicine. Kingdom of Saudi Arabia. 155 Hanzhong Road, Nanjing, Jiangsu Province, China. 210029 Dr. Jin Tao Professor and Dong-Wu Scholar, Dr. Naseem Ahmad Department of Neurobiology, Young Scientist (DST, FAST TRACK Scheme) Medical College of Soochow University, Plant Biotechnology Laboratory 199 Ren-Ai Road, Dushu Lake Campus, Department of Botany Suzhou Industrial Park, Aligarh Muslim University Suzhou 215123, Aligarh- 202 002,(UP) P.R.China. India. Dr. Pongsak Rattanachaikunsopon Dr. Isiaka A. Ogunwande Department of Biological Science, Dept. Of Chemistry, Faculty of Science, Lagos State University, Ojo, Lagos, Ubon Ratchathani University, Nigeria. Ubon Ratchathani 34190, Thailand. Editorial Board Prof Hatil Hashim EL-Kamali Dr. Arash Kheradmand Omdurman Islamic University, Botany Department, Lorestan University, Sudan. Iran. Prof. Dr. Muradiye Nacak Prof Dr Cemşit Karakurt Department of Pharmacology, Faculty of Medicine, Pediatrics and Pediatric Cardiology Gaziantep University, Inonu University Faculty of Medicine, Turkey. Turkey. Dr. Sadiq Azam Samuel Adelani Babarinde Department of Biotechnology, Department of Crop and Environmental Protection, Abdul Wali Khan University Mardan, Ladoke Akintola University of Technology, Pakistan. Ogbomoso Nigeria. Kongyun Wu Department of Biology and Environment Engineering, Dr.Wafaa Ibrahim Rasheed Guiyang College, Professor of Medical Biochemistry National Research Center China. Cairo Egypt. Prof Swati Sen Mandi Division of plant Biology, Bose Institute India. Dr. Ujjwal Kumar De Indian Vetreinary Research Institute, Izatnagar, Bareilly, UP-243122 Veterinary Medicine, India. Journal of Medicinal Plants Research Table of Contents: Volume 12 Number 27 10 November, 2018 ARTICLES A review on the botanical aspects, phytochemical contents and pharmacological activities of Warburgia ugandensis 448 Denis Okello, Richarh Komakech, Motlalepula Gilbert Matsabisa and Youngmin Kang Antibacterial and antioxidant potential of Albizia anthelmintica as a medicinal plant on pathogenic veterinary isolates 456 Kabo Wale, Tebogo Elvis Kwape, Laurah Sethibe, Goabaone Gaobotse, Daniel Loeto and Bongani Sethebe In vitro antibacterial and antidiarraheic activity of root bark extract of Anogeissus leiocarpa (Combretaceae) during an experimental bacterial diarrhea induced by Escherichia coli extended-spectrum β-lactamases (ESBL) in albino Wistar rats 463 Kouangbé Mani Adrien, Sonan Kouadio Henri Guillaume, Méité Souleymane, Boga Gogo Lucien and N’Guessan Jean David Antioxidant and antiproliferative activities of ethanolic extracts of Elateriospermum tapos Blume (Euphorbiaceae) 474 Sita Tisadondilok, Thanaset Senawong, Prasan Swatsitang and Auamporn Rattanasing Vol. 12(27), pp. 448-455, 10 November, 2018 DOI: 10.5897/JMPR2018.6626 Article Number: 3A867A858915 ISSN: 1996-0875 Copyright ©2018 Author(s) retain the copyright of this article Journal of Medicinal Plants Research http://www.academicjournals.org/JMPR Review A review on the botanical aspects, phytochemical contents and pharmacological activities of Warburgia ugandensis Denis Okello1, 2, 4, Richarh Komakech1, 5, Motlalepula Gilbert Matsabisa3 and Youngmin Kang1, 4* 1Department of Physics, University of Science and Technology (UST)-Korea Institute of Oriental Medicine Campus, Daejeon 34054, Republic of Korea. 2Gombe Secondary School, P. O. Box, 192, Butambala/Mpigi, Uganda, East Africa. 3Department of Pharmacology Faculty of Health Sciences University of Free State, Bloemfontein, 9300 South Africa. 4Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea. 5Natural Chemotherapeutics Research Institute, Ministry of Health, Kampala, Uganda. Received 15 June, 2018; Accepted 9 August, 2018 Warburgia ugandensis Sprague (Family Canellacea) commonly known as Ugandan greenheart or pepper bark tree, is a highly valued medicinal plant in traditional medicine with a broad spectrum of antimicrobial activity whose parts especially the leaves and stem bark have for long been used in the treatment and management of many diseases and health conditions such as stomachache, cough, toothache, fever, malaria, oral thrush, measles and diarrhea in African communities where the plant occurs. This review focused on the phytochemical contents, medicinal uses and antimicrobial activities of W. ugandensis based published peer reviewed articles. This review established that the high therapeutic value of W. ugandensis is attributed to the abundance of drimane sesquiterpenes in its stem bark and leaves. These chemicals have also made the plant to have potent antibacterial and antifungal activities. However, more pre-clinical and clinical trials need to be done to further validate the traditional medicine applications of W. ugandensis for possible drug discovery. Due to its high demand, W. ugandensis has been over exploited and hence its population is in drastic decline. Consequently, there is need for development of advanced and more rapid propagation techniques to increase its population and distribution in its natural environment to meet the ever-increasing demand. Key words: Antimicrobial, Canellaceae, medicinal uses, phytochemicals, Warburgia ugandensis. INTRODUCTION Warburgia ugandensis Sprague (Family Canellaceae) is a plant with immense medicinal values with restricted *Corresponding author. E-mail: [email protected]. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License Okello et al. 449 distribution in tropical Africa (Muller et al., 2015). It is Botany and distribution of W. ugandensis commonly known as the “Uganda Green Heart Tree” or the “Pepper bark tree” with a unique characteristic bitter- W. ugandensis is an evergreen plant with a spreading peppery taste (Njire et al., 2014). Owing to its rounded crown (Figure 1a). It grows to about 4.5 to 40 m antimicrobial activities, W. ugandensis have been widely in height and diameter of about 70 cm at breast height used throughout its distribution range to treat and (Figure 1a) with a smooth or scaly, pale green or brown manage myriad of diseases and disorders since time stem bark (Orwa, 2009) (Figure 1b); leaves are simple, immemorial including cough, toothache, common cold, alternate, stalked, glossy, short, with a presence of dotted bronchial infections, parasitic infections, stomachache, glands (Figure 1d); flowers are solitary or in small 3-4 fever, malaria, oral thrush, muscle pain, cystitis, flowered cymes, axillary, regular and bisexual (Maundu constipation, weak joints, measles, and diarrhea among and Tengnas, 2005). The fruit is a berry, at first green others (Lovett et al., 2006; Henke, 1994; Kiringe, 2006; and ellipsoidal, later sub-spherical and turning purplish on Kokwaro, 2009; Wamalwa et al., 2006). Indeed, W. maturation (Figure 1c); seeds are compressed and more ugandensis is a highly valued plant species in African or less cordate, yellow-brown in colour (Beentje et al., traditional health systems especially within the 1994). In fact, W. ugandensis is a hermaphroditic plant. communities where it naturally grows (Were et al., 2015). Ecologically, W. ugandensis occurs in lowland In fact, due to the increasing demand for chemical rainforests, upland dry evergreen forests, secondary diversity in screening programs, and seeking therapeutic bush and grasslands and on termitaria in swamp forests drugs from natural products,