Sinusoidal CD30-Positive Large B-Cell Lymphoma: a Morphologic Mimic of Anaplastic Large Cell Lymphoma Raymond Lai, M.D., Ph.D., L
Sinusoidal CD30-Positive Large B-Cell Lymphoma: A Morphologic Mimic of Anaplastic Large Cell Lymphoma Raymond Lai, M.D., Ph.D., L. Jeffrey Medeiros, M.D., Laith Dabbagh, M.Sc., Kimberly S. Formenti, Robert W. Coupland, M.D. Departments of Laboratory Medicine and Pathology, University of Alberta (RL), and Cross Cancer Institute (LD, KSF, RWC), Edmonton, Alberta, Canada; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas (LJM) infection can be found in a small subset of these Anaplastic large cell lymphoma (ALCL) has been neoplasms. recognized recently as a distinct clinicopathologic entity, restricted to a subset of CD30-positive diffuse KEY WORDS: CD30, Large B-cell lymphoma, large cell lymphomas of T/null lineage. Some of the Sinusoidal. characteristic features of ALCL, such as CD30 anti- Mod Pathol 2000;13(3):223–228 gen expression and the presence of large pleomor- phic lymphoid cells infiltrating lymph node sinuses, Anaplastic large cell lymphoma (ALCL), first de- can be found rarely in diffuse large B-cell lympho- scribed as Ki-1 (CD30)-positive large cell lym- mas. We collected 11 such cases, and their clinical, phoma, has been recognized as a clinicopathologic morphologic, and immunophenotypic features are entity (1). ALCL was originally described by Stein et reviewed. The age of the patients ranged from 36 to al. (2) as a neoplasm composed of large pleomor- 82 years (mean, 63.2 years) with a male to female phic lymphoid cells that express the CD30 antigen ratio of 1:1.2. All neoplasms were nodal with a sinu- and have a propensity to involve lymph node si- soidal infiltrative pattern, although four neoplasms nuses.
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