Human Anatomy Lab - Examination of the Cranial Nerves
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Cranial Nerves
Cranial Nerves (1,5,7,8,9,10,11 and 12) Slides not included 9th and 10th Cranial 11th and 12th Cranial 8th Cranial Nerve 5th and 7th Cranial 1st Cranial Nerve Nerves Nerves Nerves (3,7,11,12,13,21,23,24) - (10,16) (12,23) Slides included: (14 to 17) *Slides that are not included mostly are slides of summaries or pictures. Nouf Alabdulkarim. Med 435 Olfactory Nerve [The 1st Cranial Nerve] Special Sensory Olfactory pathway 1st order neuron Receptors Axons of 1st order Neurons Olfactory receptors are specialized, ciliated nerve cells The axons of these bipolar cells 12 -20 fibers form the that lie in the olfactory epithelium. true olfactory nerve fibers. Which passes through the cribriform plate of ethmoid → They join the olfactory bulb Preliminary processing of olfactory information It is within the olfactory bulb, which contains interneurones and large Mitral cells; axons from the latter leave the bulb to form the olfactory tract. nd 2 order neuron • It is formed by the Mitral cells of olfactory bulb. • The axons of these cells form the olfactory tract. • Each tract divides into 2 roots at the anterior perforated substance: Lateral root Medial root Carries olfactory fibers to end in cortex of the Uncus & • crosses midline through anterior commissure adjacent part of Hippocampal gyrus (center of smell). and joins the uncrossed lateral root of opposite side. • It connects olfactory centers of 2 cerebral hemispheres. • So each olfactory center receives smell sensation from both halves of nasal cavity. NB. Olfactory pathway is the only sensory pathway which reaches the cerebral cortex without passing through the Thalamus . -
Cranial Nerve Palsy
Cranial Nerve Palsy What is a cranial nerve? Cranial nerves are nerves that lead directly from the brain to parts of our head, face, and trunk. There are 12 pairs of cranial nerves and some are involved in special senses (sight, smell, hearing, taste, feeling) while others control muscles and glands. Which cranial nerves pertain to the eyes? The second cranial nerve is called the optic nerve. It sends visual information from the eye to the brain. The third cranial nerve is called the oculomotor nerve. It is involved with eye movement, eyelid movement, and the function of the pupil and lens inside the eye. The fourth cranial nerve is called the trochlear nerve and the sixth cranial nerve is called the abducens nerve. They each innervate an eye muscle involved in eye movement. The fifth cranial nerve is called the trigeminal nerve. It provides facial touch sensation (including sensation on the eye). What is a cranial nerve palsy? A palsy is a lack of function of a nerve. A cranial nerve palsy may cause a complete or partial weakness or paralysis of the areas served by the affected nerve. In the case of a cranial nerve that has multiple functions (such as the oculomotor nerve), it is possible for a palsy to affect all of the various functions or only some of the functions of that nerve. What are some causes of a cranial nerve palsy? A cranial nerve palsy can occur due to a variety of causes. It can be congenital (present at birth), traumatic, or due to blood vessel disease (hypertension, diabetes, strokes, aneurysms, etc). -
MR Imaging of Primary Trochlear Nerve Neoplasms
707 MR Imaging of Primary Trochlear Nerve Neoplasms Lindell R. Gentry 1 We present the clinical, anatomic, and MR imaging findings in six patients with seven Rahul C. Mehta 1 primary trochlear nerve neoplasms, as well as the MR and clinical criteria that serve to Richard E. Appen2 establish the diagnosis of these rare cranial nerve neoplasms. Three patients had a Joel M. Weinstein2 history of neurofibromatosis and five patients had clinical evidence of a trochlear nerve palsy. Six of seven neoplasms produced localized, fusiform enlargement of the proximal cisternal segments of the trochlear nerves. The lesions that were visible on noncontrast MR scans (T1-, T2-, and proton density-weighted) had signal intensities that were virtually identical to normal brain parenchyma. All lesions showed intense, homogeneous enhancement on contrast-enhanced scans. Contrast-enhanced imaging was necessary for the detection of five of seven lesions and greatly increased the value of the MR study in all six patients. AJNR 12:707-713, July/August 1991; AJR 157: September 1991 Primary neoplasms arising from pure motor cranial nerves such as the trochlear nerve are rare. To our knowledge just nine primary trochlear nerve neoplasms have been reported in the literature [1-7), only one of which was imaged with MR [1). Over the last 6 years, since we began to use MR as the primary imaging method for evaluating patients with cranial nerve palsies , we have noticed a striking increase in the number of primary trochlear nerve neoplasms over those encountered during the CT era. We believe this is due to a much greater sensitivity of MR in detecting these typically small lesions. -
Congenital Oculomotor Palsy: Associated Neurological and Ophthalmological Findings
CONGENITAL OCULOMOTOR PALSY: ASSOCIATED NEUROLOGICAL AND OPHTHALMOLOGICAL FINDINGS M. D. TSALOUMAS1 and H. E. WILLSHA W2 Birmingham SUMMARY In our group of patients we found a high incidence Congenital fourth and sixth nerve palsies are rarely of neurological abnormalities, in some cases asso associated with other evidence of neurological ahnor ciated with abnormal findings on CT scanning. mality, but there have been conflicting reports in the Aberrant regeneration, preferential fixation with literature on the associations of congenital third nerve the paretic eye, amblyopia of the non-involved eye palsy. In order to clarify the situation we report a series and asymmetric nystagmus have all been reported as 1 3 7 of 14 consecutive cases presenting to a paediatric associated ophthalmic findings. - , -9 However, we tertiary referral service over the last 12 years. In this describe for the first time a phenomenon of digital lid series of children, 5 had associated neurological elevation to allow fixation with the affected eye. Two abnormalities, lending support to the view that con children demonstrated this phenomenon and in each genital third nerve palsy is commonly a manifestation of case the accompanying neurological defect was widespread neurological damage. We also describe for profound. the first time a phenomenon of digital lid elevation to allow fixation with the affected eye. Two children demonstrated this phenomenon and in each case the PATIENTS AND METHODS accompanying neurological defect was profound. The Fourteen children (8 boys, 6 girls) with a diagnosis of frequency and severity of associated deficits is analysed, congenital oculomotor palsy presented to our paed and the mechanism of fixation with the affected eye is iatric tertiary referral centre over the 12 years from discussed. -
Cranial Nerves 1, 5, 7-12
Cranial Nerve I Olfactory Nerve Nerve fiber modality: Special sensory afferent Cranial Nerves 1, 5, 7-12 Function: Olfaction Remarkable features: – Peripheral processes act as sensory receptors (the other special sensory nerves have separate Warren L Felton III, MD receptors) Professor and Associate Chair of Clinical – Primary afferent neurons undergo continuous Activities, Department of Neurology replacement throughout life Associate Professor of Ophthalmology – Primary afferent neurons synapse with secondary neurons in the olfactory bulb without synapsing Chair, Division of Neuro-Ophthalmology first in the thalamus (as do all other sensory VCU School of Medicine neurons) – Pathways to cortical areas are entirely ipsilateral 1 2 Crania Nerve I Cranial Nerve I Clinical Testing Pathology Anosmia, hyposmia: loss of or impaired Frequently overlooked in neurologic olfaction examination – 1% of population, 50% of population >60 years Aromatic stimulus placed under each – Note: patients with bilateral anosmia often report nostril with the other nostril occluded, eg impaired taste (ageusia, hypogeusia), though coffee, cloves, or soap taste is normal when tested Note that noxious stimuli such as Dysosmia: disordered olfaction ammonia are not used due to concomitant – Parosmia: distorted olfaction stimulation of CN V – Olfactory hallucination: presence of perceived odor in the absence of odor Quantitative clinical tests are available: • Aura preceding complex partial seizures of eg, University of Pennsylvania Smell temporal lobe origin -
Cranial Nerve VIII
Cranial Nerve VIII Color Code Important (The Vestibulo-Cochlear Nerve) Doctors Notes Notes/Extra explanation Please view our Editing File before studying this lecture to check for any changes. Objectives At the end of the lecture, the students should be able to: ✓ List the nuclei related to vestibular and cochlear nerves in the brain stem. ✓ Describe the type and site of each nucleus. ✓ Describe the vestibular pathways and its main connections. ✓ Describe the auditory pathway and its main connections. Due to the difference of arrangement of the lecture between the girls and boys slides we will stick to the girls slides then summarize the pathway according to the boys slides. Ponto-medullary Sulcus (cerebello- pontine angle) Recall: both cranial nerves 8 and 7 emerge from the ventral surface of the brainstem at the ponto- medullary sulcus (cerebello-pontine angle) Brain – Ventral Surface Vestibulo-Cochlear (VIII) 8th Cranial Nerve o Type: Special sensory (SSA) o Conveys impulses from inner ear to nervous system. o Components: • Vestibular part: conveys impulses associated with body posture ,balance and coordination of head & eye movements. • Cochlear part: conveys impulses associated with hearing. o Vestibular & cochlear parts leave the ventral surface* of brain stem through the pontomedullary sulcus ‘at cerebellopontine angle*’ (lateral to facial nerve), run laterally in posterior cranial fossa and enter the internal acoustic meatus along with 7th (facial) nerve. *see the previous slide Auditory Pathway Only on the girls’ slides 04:14 Characteristics: o It is a multisynaptic pathway o There are several locations between medulla and the thalamus where axons may synapse and not all the fibers behave in the same manner. -
Facial Nerves Was Found in This Patient with a Unilateral Pure Motor Stroke Due to Ischaemia in the Pons
73272ournal ofNeurology, Neurosurgery, and Psychiatry 1995;58:732-734 SHORT REPORT J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.58.6.732 on 1 June 1995. Downloaded from Volitional type of facial palsy associated with pontine ischaemia Rudolf T6pper, Christoph Kosinski, Michael Mull Abstract nounced during voluntary contraction A dissociation between voluntary and whereas emotionally triggered contractions emotional facial innervation is described are preserved or at times even exaggerated on in a patient with a pure motor stroke due the paretic side.' In the emotional type of to a unilateral ischaemic pontine infarc- facial palsy the opposite phenomenon can be tion. Voluntary facial innervation of the seen: whereas voluntary triggered contrac- contralateral orbicularis oris muscle was tions are normal, there is facial impairment affected whereas emotionally induced during emotionally triggered movements. innervation of the same muscle was Automatic voluntary dissociation is not spared. This report provides evidence restricted to muscles supplied by the facial that fibres conveying voluntary and emo- nerve: in the bilateral anterior opercular syn- tional commands are still separated in drome automatic voluntary dissociation is Department of the pons. Whereas corticobulbar tracts also seen in masticatory muscles supplied by Neurology carry the information for voluntary facial the trigeminal nerve, in the tongue, and in R Topper innervation, efferents from the amygdala muscles involved in swallowing.2 Whereas the C Kosinski and the lateral hypothalamus are candi- volitional type of facial palsy is thought to be Department of Neuroradiology, dates for the somatomotor aspects of caused by a lesion in the motor cortex or in Technical University emotions. -
Atlas of the Facial Nerve and Related Structures
Rhoton Yoshioka Atlas of the Facial Nerve Unique Atlas Opens Window and Related Structures Into Facial Nerve Anatomy… Atlas of the Facial Nerve and Related Structures and Related Nerve Facial of the Atlas “His meticulous methods of anatomical dissection and microsurgical techniques helped transform the primitive specialty of neurosurgery into the magnificent surgical discipline that it is today.”— Nobutaka Yoshioka American Association of Neurological Surgeons. Albert L. Rhoton, Jr. Nobutaka Yoshioka, MD, PhD and Albert L. Rhoton, Jr., MD have created an anatomical atlas of astounding precision. An unparalleled teaching tool, this atlas opens a unique window into the anatomical intricacies of complex facial nerves and related structures. An internationally renowned author, educator, brain anatomist, and neurosurgeon, Dr. Rhoton is regarded by colleagues as one of the fathers of modern microscopic neurosurgery. Dr. Yoshioka, an esteemed craniofacial reconstructive surgeon in Japan, mastered this precise dissection technique while undertaking a fellowship at Dr. Rhoton’s microanatomy lab, writing in the preface that within such precision images lies potential for surgical innovation. Special Features • Exquisite color photographs, prepared from carefully dissected latex injected cadavers, reveal anatomy layer by layer with remarkable detail and clarity • An added highlight, 3-D versions of these extraordinary images, are available online in the Thieme MediaCenter • Major sections include intracranial region and skull, upper facial and midfacial region, and lower facial and posterolateral neck region Organized by region, each layered dissection elucidates specific nerves and structures with pinpoint accuracy, providing the clinician with in-depth anatomical insights. Precise clinical explanations accompany each photograph. In tandem, the images and text provide an excellent foundation for understanding the nerves and structures impacted by neurosurgical-related pathologies as well as other conditions and injuries. -
Anatomy of the Extraneural Blood Supply to the Intracranial
British Journal of Ophthalmology 1996; 80: 177-181 177 the extraneural blood to the Anatomy of supply Br J Ophthalmol: first published as 10.1136/bjo.80.2.177 on 1 February 1996. Downloaded from intracranial oculomotor nerve Mark Cahill, John Bannigan, Peter Eustace Abstract have since been classified as extraneural vessels Aims-An anatomical study was under- as they arise from outside the nerve and ramify taken to determine the extraneural blood on the surface ofthe nerve. In 1965, Parkinson supply to the intracranial oculomotor attempted to demonstrate and name the nerve. branches of the intracavernous internal carotid Methods-Human tissue blocks contain- artery.3 One of these branches, the newly titled ing brainstem, cranial nerves II-VI, body meningohypophyseal trunk was seen to pro- of sphenoid, and associated cavernous vide a nutrient arteriole to the oculomotor sinuses were obtained, injected with con- nerve in the majority of dissections. The infe- trast material, and dissected using a rior hypophyseal artery was also seen to arise stereoscopic microscope. from the meningohypophyseal trunk. Seven Results-Eleven oculomotor nerves were years earlier McConnell had demonstrated dissected, the intracranial part being that this vessel provided a large portion of the divided into proximal, middle, and distal pituitary blood supply.4 (intracavernous) parts. The proximal part Asbury and colleagues provided further of the intracranial oculomotor nerve anatomical detail in 1970.5 They set out to received extraneural nutrient arterioles explain the clinical findings of diabetic oph- from thalamoperforating arteries in all thalmoplegia on a pathological basis. Using a specimens and in six nerves this blood serial section technique, they demonstrated an supply was supplemented by branches intraneural network of small arterioles within from other brainstem vessels. -
Somatotopic Organization of Perioral Musculature Innervation Within the Pig Facial Motor Nucleus
Original Paper Brain Behav Evol 2005;66:22–34 Received: September 20, 2004 Returned for revision: November 10, 2004 DOI: 10.1159/000085045 Accepted after revision: December 7, 2004 Published online: April 8, 2005 Somatotopic Organization of Perioral Musculature Innervation within the Pig Facial Motor Nucleus Christopher D. Marshall a Ron H. Hsu b Susan W. Herring c aTexas A&M University at Galveston, Galveston, Tex., bDepartment of Pediatric Dentistry, University of North Carolina, Chapel Hill, N.C., and cDepartment of Orthodontics, University of Washington, Seattle, Wash., USA Key Words pools of the lateral 4 of the 7 subnuclei of the facial motor Somatotopy W Innervation W Facial nucleus W Perioral nucleus. The motor neuron pools of the perioral muscles muscles W Orbicularis oris W Buccinator W Mammals were generally segregated from motoneurons innervat- ing other facial muscles of the rostrum. However, motor neuron pools were not confined to single nuclei but Abstract instead spanned across 3–4 subnuclei. Perioral muscle The orbicularis oris and buccinator muscles of mammals motor neuron pools overlapped but were organized so- form an important subset of the facial musculature, the matotopically. Motor neuron pools of portions of the perioral muscles. In many taxa, these muscles form a SOO overlapped greatly with each other but exhibited a robust muscular hydrostat capable of highly manipula- crude somatotopy within the SOO motor neuron pool. tive fine motor movements, likely accompanied by a spe- The large and somatotopically organized SOO motor cialized pattern of innervation. We conducted a retro- neuron pool in pigs suggests that the upper lip might be grade nerve-tracing study of cranial nerve (CN) VII in pigs more richly innervated than the other perioral muscles (Sus scrofa) to: (1) map the motor neuron pool distribu- and functionally divided. -
Auditory & Vestibular Systems Steven Mcloon Department of Neuroscience University of Minnesota
Auditory & Vestibular Systems Steven McLoon Department of Neuroscience University of Minnesota 1 The auditory & vestibular systems have many similarities. • The sensory apparatus for both are in canals embedded in the bone of the inner ear. • Receptor cells (hair cells) for both are mechanosensory cells with fine stereocilia. • Information for both is carried into the brain via the vestibulochoclear nerve (cranial nerve VIII). 2 Auditory System • The auditory system detects and interprets sound. • Sound is the vibration of air molecules similar to ripples in water that propagate from a thrown rock. • The sound waves have an amplitude (loudness) and frequency (pitch). 3 Auditory System • Humans can typically hear 20 – 20,000 hertz (cycles per second). 4 Auditory System • Humans can typically hear 20 – 20,000 hertz (cycles per second). http://en.wikipedia.org/wiki/Audio_frequency 5 Auditory System • As a person ages, he/she loses the ability to hear high and low frequencies. 6 Auditory System External ear: • includes the pinna, external auditory meatus (ear canal) and tympanic membrane (ear drum). • The pinna and canal collect sound and guide it to the tympanic membrane. • The tympanic membrane vibrates in response to sound. 7 Auditory System Middle ear: • It is an air filled chamber. • The eustachian tube (auditory tube) connects the middle ear chamber with the pharynx (throat). • Three tiny bones in the chamber transfer the vibration of the tympanic membrane to the oval window of the inner ear. • Two tiny muscles can dampen the movement of the tympanic membrane and bones to protect against a loud sound. 8 Auditory System Inner ear: • The cochlea is a snail shaped tube incased in bone. -
VESTIBULAR SYSTEM (Balance/Equilibrium) the Vestibular Stimulus Is Provided by Earth's Gravity, and Head/Body Movement. Locate
VESTIBULAR SYSTEM (Balance/Equilibrium) The vestibular stimulus is provided by Earth’s gravity, and head/body movement. Located in the labyrinths of the inner ear, in two components: 1. Vestibular sacs - gravity & head direction 2. Semicircular canals - angular acceleration (changes in the rotation of the head, not steady rotation) 1. Vestibular sacs (Otolith organs) - made of: a) Utricle (“little pouch”) b) Saccule (“little sac”) Signaling mechanism of Vestibular sacs Receptive organ located on the “floor” of Utricle and on “wall” of Saccule when head is in upright position - crystals move within gelatinous mass upon head movement; - crystals slightly bend cilia of hair cells also located within gelatinous mass; - this increases or decreases rate of action potentials in bipolar vestibular sensory neurons. Otoconia: Calcium carbonate crystals Gelatinous mass Cilia Hair cells Vestibular nerve Vestibular ganglion 2. Semicircular canals: 3 ring structures; each filled with fluid, separated by a membrane. Signaling mechanism of Semicircular canals -head movement induces movement of endolymph, but inertial resistance of endolymph slightly bends cupula (endolymph movement is initially slower than head mvmt); - cupula bending slightly moves the cilia of hair cells; - this bending changes rate of action potentials in bipolar vestibular sensory neurons; - when head movement stops: endolymph movement continues for slightly longer, again bending the cupula but in reverse direction on hair cells which changes rate of APs; - detects “acceleration”