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IMC University of Applied Sciences Krems, Austria Studying the international way IMC University of Applied Sciences Krems, Austria Bernhard Klausgraber The University of Applied Sciences Krems Guiding Principles We are an Austrian university with an international focus. We offer practice-oriented degree programmes according to the needs of the industry which fulfil international university standards. Location – close to Vienna 2 venues in Krems: . International Campus KREMS Piaristengasse . Campus Krems Around 1.800 students Around 2.500 graduates Three Schools School of Business School of Health School of Life Sciences School of Life Sciences Bachelor & Master programmes (in English) Medical & Pharmaceutical Biotechnology (BSc und MSc) Regulatory Affairs (MSc) Nat. & internat. Lecturers Universities: Universities of Applied Sciences: Danube Univ. Krems FH Tulln BOKU Vienna FH Hagenberg Med. University of Vienna FH Lübeck University of Technology FH Biberach Vienna University of Economics Rentselear Polytechnic Institute Troy University of Linz University of Rostock University of Greifswald University of Augusta University of Boston Clinics: Research Centers: AKH Vienna FZ Karlsruhe Hospital Tulln Czech Acad. Sc. Nove Hrady Fraunhofer Institute Leipzig European Patent Office Ludwig Boltzmann Institute Wien Munich Lecturers from LifeScience Companies Companies: Topics: Sanofi/Aventis, Vienna => Drug Law Baxter Bioscience, Vienna => Project Management Boehringer Ingelheim, Vienna => Quality Management Fresenius Medical Care, B. Homburg => Scientific Marketing Membrana, Wuppertal => Spec. Material Science Miltenyi, Teterow => Pharm. Expression Octapharma, Wien => Pharm. Production Pfizer, Wien => Medical Products Roche, Basel => Pharma. Marketing Sandoz/Novartis, Kundl => Pharma. Production ViruSure GmbH => Quality Management Technology Companies: ArsArthro GmbH, Krems => Medical Biotechnol. ARWIG GmbH, Vienna => Biostatistics Biotec Systems GmbH, Krems => Adsorber Technologies InterCell GmbH, Vienna => Patent Law DOT GmbH, Rostock => Implant Material Science Rational GmbH, Rostock => Process Technology WSB GmbH, Krems => Material Science Ministry and Agencies => Clinical Studies => GMP / GCP Biotechnology at IMC stands for a balanced practical orientation • The balanced interdisciplinary study program covers the whole „Value Chain“ from R&D to the approval of new drugs or medical products • The methodical orientation and problem-solving abilities as first educational principle • A full-time lecturer team with significant practical experiences – International education : Austria => Med Univ. Vienna, Univ. Salzburg Germany => Univ. Rostock Slovakia => Univ. Bratislava GB => Strathclyde Univ. Glasgow USA => Cornell Univ. Medical Scholl, New York Japan => Jikei Univ, Tokyo - International research projects: Germany => Zeiss Jena, Fresenius Homburg USA => Beckman, PenKem New York Japan => JMS Hiroshima - International networking Scandinavia => EU – Life Science Region EC-Projects => Assessment procedure for innovative start-ups 9 - Our concept stands out against the classical (biotechnology) education • Broad and practical orientation • Teaching contents based on a survey including the pharmaceutical industry • Balanced program between biomedicine and technology covers the whole “value chain” from R&D up to approval of new drugs or medical product • High percentage of quality elements incorporated in lectures and various laboratory course • Methodical orientation and problem-solving abilities as first educational .... • Modular design of the study program • Flexibility for participation in international joint programs Bachelor program: 6 Semesters Focus on basic knowledge to understand complex processes and training of practical skills in: • Basic Bio-Sciences Biophysics, Mathematics, Chemistry, Biochemistry, Microbiology, Physiology, Diseases, Genetics, Pharmacology, Bioinformatics, Physiology, Medicine • Special Laboratory Techniques Cell Culture, Genetic Engineering, Fermentation, Instrumental Analytics, Clean Room Training • Quality Management Project Management, GLP, GMP, GCP, Industrial Hygiene • Bioprocess Technologies Bioengineering, Pharmaceutical Production Systems • Practical Training 8 months (mostly abroad) 11 Master program: 4 Semesters Specialisation in: • Pharmaceutical Production Technologies Recombinant Protein Production, Fermentation, Bioseparation, Quality Management and Validation • Medical Biotechnology / Regenerative Medicine Tissue Engineering, Cancer, Aging, Artificial Organs, Nanobiotechnology • Management Business Administration, Quality and Project M., Regulatory Affairs, Patenting, Licensing, Marketing • Research Semester in Universities and Industry in 25 countries 12 International … ?! . International students . International Visiting Professors and guest lecturers . 60 % of students for bachelor/master thesis abroad . 9. International Life Science Meeting of IMC FH Krems . EC-project Interreg . EC-IP-Course . ESAO Summer School „Biomaterials and Regenerative Medicine“ . Lectures, posters and chairmanship at international conferences 13 Lecturer at FH Krems Prof. Ivar Giaever, USA Nobel Prize in 1973 together with Esaki and Josephson “Electron Tunneling” Giaever´s Company: e.g. Wound Healing Assay Fibroblasten und/oder Fibrinmatrix Endothelzellen R&D Profil of the Inst. Biotechnology Elektrode Richtung der Migration New cell-based technologies for testing Keratinozyten of bioactive substances Coop with Industry, Universities, EU 3.6 Mio. Project volume Our Research Concept: • Current projects • Students in research • Scientific work • Publications • Conferences • Cooperations 16 Our Research Concept: 1. Development of unique methods and technologies 2. Cooperation with partners: Application research and service Development of new methods Participation in life science programms 3. Use of methods and technologies in education 4. Partner in international scientific networks 5. Foundation of start-up company or research center 17 Our Research Concept: Research Focus Medical Biotechnology: 1. Drug Discovery and Therapeutic Strategies in Cancer, Inflammation and Regenerative Medicine 2. Bioprocess Technology 18 Our Research Concept Core Competences of Group Leaders Cancer Research Instrument Cell Biology Development Innovative Assay Development Drug Discovery Biochemistry Tissue Regenerative Regeneration Medicine 19 Our Research Concept Potential for Synergy: Cooperation between the working teams Novel experimental methods Cell-based Testsystems Tissue Engineering Drug Discovery Ultimate Goal: Development of Lead Compounds, Therapeutics and Diagnostics 20 Our Research Concept Organotypic Tumor Models in the Drug Discovery Process Phenotype Based Drug Discovery Phases of the drug discovery process: Target Identification RNAi based Screening Techniques .Non-invasive assay development to detect drug Target Validation induced reversions of the hallmarks of cancer - Inhibition of Proliferation - Induction of Apoptosis Lead Identification - Induction of Senescence - Induction of Differentiation - Inhibition of Invasion Lead Optimization .Signaling Pathway Analysis .Genotype-Drug Response Analysis Preclinical and Clinical development Breast Cancer Cells MDA-MB-231 MDA-MB-415 MDA-MB-468 MCF7 ZR-75-1 2D Spheroids Dendritic Cell Based Cancer Therapy Dendritic Cell Based Cancer Therapy Personalized Medicine in Cancer Screening of Marine Substances Establishment of 3D Tumor-Speroids Hanging Drop Rotory Wall Vessel Cultivation of marine Organisms Pre-Screening of marine Substances 2D Assays 0 h 24 h 48 h 120 h n.c. 30µg Isolation of bioactive Screening of marine Substances 30µg Substances 1,2 3mg 1 0,8 0,6 fluorescence 0,4 0,2 relative relative 0 Tumor-Immuntherapy -isolation of white blood cells -downregulation of cbl b silencing -injection of activated cells 29 Establishment of organotypic 3D Tumor Sphäroids in vitro Drug Discovery Systems • Drug screening methods Tumor models Inflammation models • Cooperation with Industrial Partners Development of a new detection platform techniques => Support of scientific marketing world-wide 32 Pharmaceutical Process Technology • Fermentation optimization Oxygen Transfer Calculation models Index numbers • Cooperation with Industrial Partners => Development of new production technologies Presentation of first results in San Diego 33 Biotechnology at IMC Krems • The balanced program covers the whole „Value Chain“ from R&D to the approval of new drugs or medical products • Methodical orientation and problem-solving abilities as first educational principle • Lecturer team with experience in international education and research projects • International networks with Life Science industry and universities => The graduates starting their career in: Industrial R&D 40% Institutions 20% PhD-programs 40% (Harvard, Cambridge, London, Oxford, Singapore, Hongkong, Antwerpen, Hannover, Aachen, Gent, Vienna, Graz, Innsbruck, Dublin, Stockholm, ..…) 34 Krems´s Specials in Numbers Nat & International Practical Training Further PhD – Studies Jobs 35 Pratical Training Semester BA and Applied Research Training Semester MA Acambis Cambridge, USA National Laboratory of Berkeley AGES, Wien Sanquin Research, Niederlande Austrian Academy of Sciences, Wien University of Alabama Baxter Bioscience, Wien University of Antwerp Baxter International, USA University of British Columbia Vancouver Biomin, Österreich University of Brussels Boehringer Ingelheim, Wien University of Groningen Chemistry School of Pharmacy, AUS University of Homburg Danube
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