Studying the international way
IMC University of Applied Sciences Krems, Austria
Bernhard Klausgraber The University of Applied Sciences Krems Guiding Principles
We are an Austrian university with an international focus.
We offer practice-oriented degree programmes according to the needs of the industry which fulfil international university standards. Location – close to Vienna
2 venues in Krems:
. International Campus KREMS Piaristengasse . Campus Krems
Around 1.800 students Around 2.500 graduates Three Schools
School of Business
School of Health
School of Life Sciences School of Life Sciences
Bachelor & Master programmes (in English)
Medical & Pharmaceutical Biotechnology (BSc und MSc) Regulatory Affairs (MSc)
Nat. & internat. Lecturers
Universities: Universities of Applied Sciences: Danube Univ. Krems FH Tulln BOKU Vienna FH Hagenberg Med. University of Vienna FH Lübeck University of Technology FH Biberach Vienna University of Economics Rentselear Polytechnic Institute Troy University of Linz University of Rostock University of Greifswald University of Augusta University of Boston
Clinics: Research Centers: AKH Vienna FZ Karlsruhe Hospital Tulln Czech Acad. Sc. Nove Hrady Fraunhofer Institute Leipzig European Patent Office Ludwig Boltzmann Institute Wien Munich
Lecturers from LifeScience Companies
Companies: Topics: Sanofi/Aventis, Vienna => Drug Law Baxter Bioscience, Vienna => Project Management Boehringer Ingelheim, Vienna => Quality Management Fresenius Medical Care, B. Homburg => Scientific Marketing Membrana, Wuppertal => Spec. Material Science Miltenyi, Teterow => Pharm. Expression Octapharma, Wien => Pharm. Production Pfizer, Wien => Medical Products Roche, Basel => Pharma. Marketing Sandoz/Novartis, Kundl => Pharma. Production ViruSure GmbH => Quality Management
Technology Companies: ArsArthro GmbH, Krems => Medical Biotechnol. ARWIG GmbH, Vienna => Biostatistics Biotec Systems GmbH, Krems => Adsorber Technologies InterCell GmbH, Vienna => Patent Law DOT GmbH, Rostock => Implant Material Science Rational GmbH, Rostock => Process Technology WSB GmbH, Krems => Material Science
Ministry and Agencies => Clinical Studies => GMP / GCP
Biotechnology at IMC stands for a balanced practical orientation
• The balanced interdisciplinary study program covers the whole „Value Chain“ from R&D to the approval of new drugs or medical products • The methodical orientation and problem-solving abilities as first educational principle • A full-time lecturer team with significant practical experiences – International education : Austria => Med Univ. Vienna, Univ. Salzburg Germany => Univ. Rostock Slovakia => Univ. Bratislava GB => Strathclyde Univ. Glasgow USA => Cornell Univ. Medical Scholl, New York Japan => Jikei Univ, Tokyo - International research projects: Germany => Zeiss Jena, Fresenius Homburg USA => Beckman, PenKem New York Japan => JMS Hiroshima - International networking Scandinavia => EU – Life Science Region EC-Projects => Assessment procedure for innovative start-ups 9
- Our concept stands out against the classical (biotechnology) education
• Broad and practical orientation • Teaching contents based on a survey including the pharmaceutical industry • Balanced program between biomedicine and technology covers the whole “value chain” from R&D up to approval of new drugs or medical product • High percentage of quality elements incorporated in lectures and various laboratory course • Methodical orientation and problem-solving abilities as first educational .... • Modular design of the study program • Flexibility for participation in international joint programs Bachelor program: 6 Semesters Focus on basic knowledge to understand complex processes and training of practical skills in:
• Basic Bio-Sciences Biophysics, Mathematics, Chemistry, Biochemistry, Microbiology, Physiology, Diseases, Genetics, Pharmacology, Bioinformatics, Physiology, Medicine • Special Laboratory Techniques Cell Culture, Genetic Engineering, Fermentation, Instrumental Analytics, Clean Room Training • Quality Management Project Management, GLP, GMP, GCP, Industrial Hygiene • Bioprocess Technologies Bioengineering, Pharmaceutical Production Systems • Practical Training 8 months (mostly abroad)
11
Master program: 4 Semesters
Specialisation in: • Pharmaceutical Production Technologies Recombinant Protein Production, Fermentation, Bioseparation, Quality Management and Validation
• Medical Biotechnology / Regenerative Medicine Tissue Engineering, Cancer, Aging, Artificial Organs, Nanobiotechnology
• Management Business Administration, Quality and Project M., Regulatory Affairs, Patenting, Licensing, Marketing
• Research Semester in Universities and Industry in 25 countries 12
International … ?!
. International students . International Visiting Professors and guest lecturers . 60 % of students for bachelor/master thesis abroad . 9. International Life Science Meeting of IMC FH Krems . EC-project Interreg . EC-IP-Course . ESAO Summer School „Biomaterials and Regenerative Medicine“ . Lectures, posters and chairmanship at international conferences
13 Lecturer at FH Krems
Prof. Ivar Giaever, USA Nobel Prize in 1973 together with Esaki and Josephson
“Electron Tunneling” Giaever´s Company:
e.g. Wound Healing Assay
Fibroblasten und/oder Fibrinmatrix Endothelzellen
R&D Profil of the Inst. Biotechnology Elektrode
Richtung der Migration New cell-based technologies for testing Keratinozyten of bioactive substances
Coop with Industry, Universities, EU 3.6 Mio. Project volume Our Research Concept:
• Current projects
• Students in research
• Scientific work
• Publications
• Conferences
• Cooperations
16 Our Research Concept:
1. Development of unique methods and technologies
2. Cooperation with partners:
Application research and service
Development of new methods
Participation in life science programms
3. Use of methods and technologies in education
4. Partner in international scientific networks
5. Foundation of start-up company or research center 17
Our Research Concept:
Research Focus Medical Biotechnology:
1. Drug Discovery and Therapeutic Strategies in Cancer, Inflammation and Regenerative Medicine
2. Bioprocess Technology
18 Our Research Concept
Core Competences of Group Leaders
Cancer Research
Instrument Cell Biology Development
Innovative Assay Development
Drug Discovery Biochemistry
Tissue Regenerative Regeneration Medicine
19 Our Research Concept
Potential for Synergy: Cooperation between the working teams
Novel experimental methods Cell-based Testsystems
Tissue Engineering
Drug Discovery Ultimate Goal: Development of Lead Compounds, Therapeutics and Diagnostics
20 Our Research Concept Organotypic Tumor Models in the Drug Discovery Process Phenotype Based Drug Discovery
Phases of the drug discovery process:
Target Identification RNAi based Screening Techniques .Non-invasive assay development to detect drug Target Validation induced reversions of the hallmarks of cancer
- Inhibition of Proliferation - Induction of Apoptosis Lead Identification - Induction of Senescence - Induction of Differentiation - Inhibition of Invasion
Lead Optimization .Signaling Pathway Analysis
.Genotype-Drug Response Analysis Preclinical and Clinical development Breast Cancer Cells
MDA-MB-231 MDA-MB-415 MDA-MB-468 MCF7 ZR-75-1
2D
Spheroids Dendritic Cell Based Cancer Therapy Dendritic Cell Based Cancer Therapy Personalized Medicine in Cancer Screening of Marine Substances
Establishment of 3D Tumor-Speroids
Hanging Drop Rotory Wall Vessel Cultivation of marine Organisms Pre-Screening of marine Substances 2D Assays
0 h 24 h 48 h 120 h
n.c.
30µg
Isolation of bioactive Screening of marine Substances 30µg Substances
1,2 3mg 1
0,8
0,6 fluorescence 0,4
0,2 relative relative 0 Tumor-Immuntherapy
-isolation of white blood cells
-downregulation of cbl b silencing
-injection of activated cells
29 Establishment of organotypic 3D Tumor Sphäroids in vitro Drug Discovery Systems
• Drug screening methods Tumor models Inflammation models
• Cooperation with Industrial Partners Development of a new detection platform techniques
=> Support of scientific marketing world-wide
32 Pharmaceutical Process Technology
• Fermentation optimization Oxygen Transfer Calculation models Index numbers
• Cooperation with Industrial Partners
=> Development of new production technologies Presentation of first results in San Diego
33 Biotechnology at IMC Krems
• The balanced program covers the whole „Value Chain“ from R&D to the approval of new drugs or medical products • Methodical orientation and problem-solving abilities as first educational principle • Lecturer team with experience in international education and research projects • International networks with Life Science industry and universities
=> The graduates starting their career in: Industrial R&D 40% Institutions 20% PhD-programs 40% (Harvard, Cambridge, London, Oxford, Singapore, Hongkong, Antwerpen, Hannover, Aachen, Gent, Vienna, Graz, Innsbruck, Dublin, Stockholm, ..…)
34 Krems´s Specials in Numbers
Nat & International Practical Training
Further PhD – Studies
Jobs
35 Pratical Training Semester BA and Applied Research Training Semester MA
Acambis Cambridge, USA National Laboratory of Berkeley AGES, Wien Sanquin Research, Niederlande Austrian Academy of Sciences, Wien University of Alabama Baxter Bioscience, Wien University of Antwerp Baxter International, USA University of British Columbia Vancouver Biomin, Österreich University of Brussels Boehringer Ingelheim, Wien University of Groningen Chemistry School of Pharmacy, AUS University of Homburg Danube University, Krems University of Melbourne Hagedorn Research Institute, DK University of Okago ICRM Montreal, Kanada University of Pecs IMC, Krems University of Queensland LCT, Australia University of Sidney LKH Klagenfurt, Klagenfurt UTSW Medical Centre Dallas LMU München, Tansania/Deutschland Cancer Cell Inst., Madrid McMaster University, Kanada University of London Morphosys, Deutschland University of Oxford Octapharma, Wien Univeristy of Cambridge Sandoz, Tirol University of Sussex Bundeskriminalamt, St.Pölten University of Singapore Vaxine Pty. Ltd. Sydney, Australia University of Hongkong Tissue Genesis Inc., Hawai New York University
Practical Training Semester BA and Applied Research Training Semester MA
Since 2005: 358 Students in 25 countries 65% abroad
Universities 187 Industry 87 SMEs 31 Research Centers 29 Gov. Offices 10
IMC Krems 14
37 Practical Training Semester BA and MA: Cooperation world-wide
Europe: 104 Germany 32 Great Britain 19 Netherlands 9 Sweden 8 Ireland 7 ….
Australia, New Z. 46 Australia 41 New Zealand 5
Amerika 40 USA 30 Canada 10
Asia 6 Singapore 4 Hongkong 1
Shanghai 1 38
Pratical Training Semester: Cooperation in Austria
Industry 47 Baxter 21 Boehringer 16 Octapharma 4
Universities 44 MedUni Graz Innsbruck Salzburg VetMed
SMEs 28
Research Centers 18
AGES 7 39
Pratical Training Semester: Cooperation in Lower Austria
Industry 35 Baxter
SMEs 22 SeaLife Pharma 8 Biomin 5 Cell Danube 5 TMB 3 Arthro Kinetics 1
Danube University 13
IMC FH Krems 14
40
The positive outcome of international practical training
The intensive personal interaction of our IMC team with the external coaches worldwide shows a positive feedback about:
=> Performance of our students regarding: structured problem solving abilities open mind for interdisciplinary projects flexibility engagement team work and management abilities
=> Possible further improvement of our educational concept Bologna process
=> Use of our students activities for the establishment of new cooperation for research projects
=> Presentations of thesis at international conferences by the graduates many of our students are invited to give talks at international conference or are authors of peer-reviewed articles
Jobs of our Graduates (Known to us)
from this in Lower Austria:
Industry 57 19
SMEs 13 5
Universitys 40 6
Gov. Offices 4
from this in PhD-program: 42
Additional Studies: 5 (Medicine, Pharmacology, Diplomacy,…)
42 Further PhD Studies in:
Austria: Med. Univ. Vienna 8 Techn. Univ. Vienna 4 Univ. Vienna 1 Univ. Graz 3 Univ. Salzburg 1 Med. Univ. Innsbruck 2 BOKU Vienna 2 USA: Boston Univ. 1 Univ. Honolulu 1 Great Britain: Univ. London 1 Royal Institution 1 Univ. Cambridge 2 Univ. Oxford 2 Kings College London 2 Belgium: Univ. Gent 1 Univ. Antwerp 1 Ireland: Univ. Dublin 3 Germany : Univ. Hannover 1 Univ. Leipzig 1 Univ. Munich 1 Univ. Kassel 1 Univ. Aachen 1 Justus Liebig Univ. Giessen 1 China: Univ. Fudan, Shanghai 1 Univ. Hongkong 1 Sweden: Karolinska Institute 1 43 Attraction for students with clear and dedicated minds: A Summary !
• Strong educational program • Preparation for interdisciplinary projects in research and industry • Team with strong experiences in education and research • Interesting research profile: financial support (actual 3.5 Mio. €) • Incorporation of representatives from industry and universities teaching newest developments in biomedicine and biotechnology • Close personal relation with industry, research institutions and universities worldwide brings on a vast variety for the preparation of the practical training semester • Until today, our biotechnology students successfully finished their 9- months- training in more than 25 countries, e.g.: Universities: Harvard, Cambridge, Antwerp, Dallas, Lund Leipzig, Singapore, Honking, Sydney Industry Europa, America, Asia, Australia, Africa • No unemployed graduates, 40% in PhD-programs world-wide