Genetics Problem Set - Sex Linkage

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Genetics Problem Set - Sex Linkage Sex-linked Traits! Don't forget to use your X's and Y's. Female _____ Male _____ Traits only travel on _____ 1. In humans, colorblindness is a sex-linked recessive trait. The dominant allele results in normal vision. What would be the results of the following crosses? A) A man who is not colorblind and a woman who is colorblind. B) A woman who is not colorblind and is heterozygous and a man who is not colorblind. 2. Baldness is a sex-linked trait found on a recessive allele. A head of full hair is the dominant trait. What would be the results for the following crosses? A) A female who is homozygous for normal hair a man who is bald. B) A female who is bald with a man who has a full head of hair. 3. In humans, a sex-linked dominant allele, R, produces rickets, a skeletal disorder. The recessive allele, r, results in normal skeletal development. What would be the results of the following crosses? A) A man with rickets and a woman who does not have rickets. B) A woman who has rickets (but whose father did not) and a man who does not have rickets. Extra Credit 4. In chickens, the Bar feather pattern is due to a sex-linked dominant allele, B. The recessive allele, b, results in non-Bar feathers. Another little situation occurs in chickens. The female is XY and the male is XX. The traits still travel on the X. Remember, the Y is missing stuff. Do the following crosses using all five traits. A) A Bar hen is mated with a non-Bar rooster. B) A non-Bar hen is mated to a Bar rooster whose mother was non-Bar. .

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Patterns of DNA methylation on the human X chromosome and use in analyzing X-chromosome inactivation by Allison Marie Cotton B.Sc., The University of Guelph, 2005 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY in The Faculty of Graduate Studies (Medical Genetics) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) January 2012 © Allison Marie Cotton, 2012 Abstract The process of X-chromosome inactivation achieves dosage compensation between mammalian males and females. In females one X chromosome is transcriptionally silenced through a variety of epigenetic modifications including DNA methylation. Most X-linked genes are subject to X-chromosome inactivation and only expressed from the active X chromosome. On the inactive X chromosome, the CpG island promoters of genes subject to X-chromosome inactivation are methylated in their promoter regions, while genes which escape from X- chromosome inactivation have unmethylated CpG island promoters on both the active and inactive X chromosomes. The first objective of this thesis was to determine if the DNA methylation of CpG island promoters could be used to accurately predict X chromosome inactivation status. The second objective was to use DNA methylation to predict X-chromosome inactivation status in a variety of tissues. A comparison of blood, muscle, kidney and neural tissues revealed tissue-specific X-chromosome inactivation, in which 12% of genes escaped from X-chromosome inactivation in some, but not all, tissues. X-linked DNA methylation analysis of placental tissues predicted four times higher escape from X-chromosome inactivation than in any other tissue. Despite the hypomethylation of repetitive elements on both the X chromosome and the autosomes, no changes were detected in the frequency or intensity of placental Cot-1 holes.
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