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||||||||| USOO5514437A United States Patent (19) 11 Patent Number: 5,514,437 Tanner et al. (45) Date of Patent: May 7, 1996 (54) ARTIFICIALTANNING COMPOSITIONS 2nd edition, Dec. 10, 1973, vol. 1, pp. 293–305 Wiley-Inter HAVING IMPROVED STABILITY Science, New York. Merck German Technical Data sheet, Nov. 24, 1993. (75) Inventors: Paul R. Tanner, Maineville; Larry R. Kawashima et al., "Nonenzymatic Browning Reactions of Robinson, Lebanon, both of Ohio Dihydroxyacetone with Amino Acide or Their Esters', Agric. Biol. Chem., 44(7), 1595–1599 (1980). (73) Assignee: The Procter & Gamble Company, Ingredient label from packaging, Bain de Soleil Tanning Cincinnati, Ohio Creme, copyright 1993. A. Meybeck, "A Spectroscopic Study of the Reaction Prod 21 Appl. No.: 219,053 ucts of Dihydroxyacetone with Amine Acids”. J. Soc. Cos 22 Filed: Mar. 29, 1994 met. Chem, 28, 25-35 (1977). E. Wittgenstein et al., “Reaction of Dihydroxyacetone (51) Int. CI.' ......................................... A6K7/02 (DHA) with Human Skin Callus and Amino Compounds', J. 152 U.S. Cl. .................................. 424/63; 424/59; 424/60 Invest. Derm, 23, 283-286 (1961). 58) Field of Search ................................... 424/63, 60,59 M. F. Bobin et al., “Effects of Color Adjuvants on the Tanning Effect of Dihydroxyacetone', J. Soc. Cosmet. 56) References Cited Chem., 35, 265,272 (Aug. 1984). U.S. PATENT DOCUMENTS Ingredient label from Elizabeth Arden's Spa for the Sun Self Tanner SPF 15 Product, no copyright date available. 2,274,725 3/1942 Meeker et al. ............................ 424/59 2,949,403 8/1960 Andreadis. The Merck Index, Tenth Edition, 1983, Entry 8476. 3,177,120 4/1965 Black et al. ... ... 424/59 V. R. Usdin, “Artificial Tanning Preparations',Cosmetics 3,184,388 5/1965 Kalopissis. ... 424/59 and Toiletries, vol. 91, Mar. 1976 pp. 29–32. 3,272,713 9/1966 Runge ........ ... 424/59 J. Buchter et al., “The Reaction of Dihydroxyacetone with 3,920,808 11/1975 Fusaro ........ ... 424/59 Proteins', American Perfumer, Dec. 1960, pp. 46-48. 4,145,413 3/1979 Usdin et al. ... 424/63 N. Kanas et al., "Factors Influencing the Tanning Effect of 4,293,543 10/1981 Cotte et al. ... 424/59 4,419,343 12/1983 Pauly ......... ... 424/59 Dihydroxyacetone of the Skin' American Perfumer, Nov. 4,434,154 2/1984 McShane ....... ... 424/60 1960, pp. 33–34. 4,831,943 5/1989 Grollier et al. ... 424/59 M. Fleming et al., "Chemistry of Browning Reaction', The 4,847,267 7/1989 Deckner et al. ... 514/311 Sugar Journal, Apr. 1971, pp. 21-27. 5,100,660 37992 Hawe et al. ............ 424/78.35 K. Laden et al., "The Reaction of o-Hydroxymethyl 5,221,530 6/1993 Janchitraponveget al. .............. 424f70 Ketones with Skin and Amino Acids, J. Soc. Cosmetic 5,232,688 8/1993 Ziegler et al. .......... ... 424/59 Chemists, 16, 777-782 (1965). 5,302,378 4/1994 Crotty et al. .............................. 424/59 Primary Examiner-Shelley A. Dodson FOREIGN PATENT DOCUMENTS Attorney, Agent, or Firm--Anthony D. Sabatelli; David K. 90/61950 5/1991 Australia ......................... A61K 7/02 Dabbiere CA72(20):103635B/1969 Czechoslovakia. 227012 7/1987 European Pat. Off. ......... A61K 7700 57 ABSTRACT 456545 4/1991 European Pat. Off. ......... A61K 7/42 547864 6/1993 European Pat. Off. ......... A61K 7/42 The present invention relates to artificial tanning composi 622070A1 11/1994 European Pat. Off. ......... A61K 7/42 tions having improved stability. These compositions com 34227937 8/1994 Japan .................... ... A61K 7/42 prise dihydroxyacetone, a salt selected from the group 98(16):132150g 10/1982 Spain ... ... A61K 62A4 consisting of metabisulfite salts, sulfite salts, hydrogen 83-825600/47 1/1983 U.S.S.R. .......................... A61K 7/OO sulfite salts, and mixtures thereof. These compositions are WO92/1759 10/1992 WIPO .............................. A61KT42 useful for imparting an artificial tanto human skin. In further WO93,092.15 5/1993 WIPO .............................. C11D 3/04 embodiments, these compositions also comprise a sunscreen OTHER PUBLICATIONS agent and are also useful for providing protection from the harmful effects of ultraviolet radiation, Technical Bulletin-Salcare SC 92 for Cosmetic/Personal Care applications, Allied Colloids, Suffolk, VA-Undated. M. S. Balsam et al., (ed.) Cosmetic Science and Technology 19 Claims, No Drawings 5,514,437 1. 2 ARTEFICAL TANNING COMPOSITIONS human skin by its reaction with the nitrogen containing HAVING MPROVED STABILITY proteins of the skin. See L. Goldman et al., “Investigative Studies with the Skin Coloring Agents Dihydroxyacetone The present invention relates to compositions useful for and Glyoxal', The Journal of Investigative Dermatology, providing an artificial tan to human skin. These composi 5 vol. 35, pp. 161-164 (1960); E. Wittgenstein et al., “Reac tions exhibit improved chemical and physical stability. tion of Dihydroxyacetone (DHA) with Human Skin Callus These compositions comprise dihydroxyacetone, a salt and Amino Compounds', The Journal of Investigative Der selected from the group consisting of metabisulfite salts, matology, vol. 36, pp. 283–286 (1961); and A. Meybeck, "A sulfite salts, and hydrogen sulfite salts, and mixtures thereof, Spectroscopic Study of the Reaction Products of Dihdyroxy and a topical carrier. In further embodiments these compo 10 acetone With Amino Acids', J. Soc. Cosmet. Chem, 25-35 sitions also comprise a sunscreen agent and are useful for (1977); all of which are incorporated by reference herein in protecting the skin from the harmful effects of ultraviolet their entirety. This incompatibility of dihydroxyacetone with radiation. nitrogen containing compounds has limited the formulation scope of artificial tanning products in the past. 15 Conventional stablilizing agents and antioxidants such as BACKGROUND OF THE INVENTION BHA, BHT, and vitamin E are ineffective for stabilizing A sun-tanned appearance is a symbol of a healthy, artificial tanning compositions containing dihydroxyac dynamic, and active life. Yet, the damaging effects of etone. Surprisingly, it is found in the present invention that sunlight and other sources of ultraviolet radiation on the skin certain salts such as metabisulfite salts, sulfite salts, and are well documented. These effects are cumulative and 20 hydrogen sulfite salts greatly enhance the stability of artifi potentially serious, and include sunburn, skin cancer, and cial tanning compositions containing dihydroxyacetone. The premature aging of the skin. These effects associated with use of metabisulfite salts as anti-oxidants is known in the exposure to ultraviolet radiation are more fully discussed in pharmaceutical area, however, their use has typically been DeSimone, "Sunscreen and Suntan Products', Handbook of limited to extremely low levels, e.g. 0.005%. In the present Nonprescription Drugs, 7th Ed., Chapter 26, pp. 499-511 25 invention, it is found that much higher levels of salts such as (American Pharmaceutical Association, Washington, D.C; metabisulfite, sulfite, and hydrogen sulfite salts, i.e. levels in 1982); Grove and Forbes, "A Method for Evaluating the the range from about 0.025% to about 5%, provide an Photoprotection Action of Sunscreen Agents Against UV-A unexpected enhancement of stability. This enhanced stabil Radiation', International Journal of Cosmetic Science, 4, ity translates into benefits such as increased product shelf pp. 15-24 (1982); and U.S. Pat. No. 4,387,089, DePolo, 30 life, good product performance, maintenance of the aesthetic issued Jun. 7, 1983, the disclosures of all of which are characteristics of the product, i.e. less discoloration and incorporated herein by reference in their entirety. off-odors, and better user acceptance. Sunscreens are the most common agents used for Sun It is therefore an object of the present invention to provide protection. However, sunscreens also have the disadvantage artificial tanning compositions useful for imparting an arti of preventing or greatly diminishing the cosmetically desir 35 ficial tan to human skin, able tanning response. Thus, if an individual uses a sun It is another object of the present invention to provide screen for protection from ultraviolet radiation, he or she artificial tanning compositions which exhibit improved does so at the expense of foregoing a tanned appearance. chemical and physical stability. Furthermore, even if an individual is willing to accept the 40 It is another object of the present invention to provide risks associated with exposure to ultraviolet radiation to artificial tanning compositions which have good color devel obtain a tan, there are situations in which it may not be opment characteristics such as providing a natural looking practical or even possible to do so because of time con and rapidly developing tan. straints, weather conditions, etc. Therefore, it would be It is another object of the present invention to provide highly desirable to develop products for providing a tanned 45 artificial tanning compositions useful for both providing an appearance to the skin, whenever desired without the need artificial tan to human skin and for protecting human skin for exposure to ultraviolet radiation. from the harmful effects of ultraviolet radiation. It is generally known that dihydroxyacetone, when It is another object of the present invention to provide a applied topically to human skin, will produce a tanned method for artificially tanning human skin. appearance, i.e. an artificial tan. U.S. Pat. No. 4,708,865, to 50 Turner, issued Nov. 24, 1987 describes the use of hydro It is another object of the present invention to provide a alcoholic solutions of dihydroxyacetone for tanning the skin; method for artificially tanning human skin and for providing U.S. Pat. No. 4,466,805, to Welters, issued Aug. 21, 1984 protection from the harmful effects of ultraviolet radiation. describes hair and skin coloring formulations containing These and other objects of this invention will become dihydroxyacetone; and U.S. Pat. No. 2,949,403, to Andrea 55 apparent in light of the following disclosure. dis et al., issued Aug. 16, 1960 describes artificial tanning formulations containing dihydroxyacetone in an oleaginous SUMMARY OF THE INVENTION base.
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