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Recollection Et Familiarité Chez 12 Patients Présentant Un Infarctus

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Recollection Et Familiarité Chez 12 Patients Présentant Un Infarctus Recollection et familiarité chez 12 patients présentant un infarctus thalamique gauche : étude comportementale, en imagerie structurale et fonctionnelle de repos Lola Danet To cite this version: Lola Danet. Recollection et familiarité chez 12 patients présentant un infarctus thalamique gauche : étude comportementale, en imagerie structurale et fonctionnelle de repos. Neurosciences. Université Paul Sabatier - Toulouse III, 2015. Français. NNT : 2015TOU30335. tel-01453172 HAL Id: tel-01453172 https://tel.archives-ouvertes.fr/tel-01453172 Submitted on 2 Feb 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. 1 « c’est, on l’a dit, une réflexion nostalgique sur l’impuissance de la réalité à recomposer les tableaux de la mémoire. » Antoine Compagnon, à propos de la Recherche du temps perdu de Marcel Proust. 2 A Yvette Rose Loria et à Charlotte Danet 3 Je remercie Jean-François Démonet et Christine Bastin pour avoir bien voulu évaluer mon travail. Je remercie Olivier Félician, Christopher Moulin et Patrice Péran d’avoir accepté de faire partie de mon jury de thèse. Jérémie Pariente, directeur de ma thèse, mais aussi collègue et partenaire de réflexion scientifique et clinique depuis plusieurs années. Merci pour cette belle aventure, les aventures passées et futures, merci pour ton engagement, ton exigence et ta sincérité. C’est une chance de travailler avec des gens comme toi. Emmanuel Barbeau, co-directeur de ma thèse, pour m’avoir introduite, durant mon Master 2, et guidée, pendant ma thèse, dans la jungle conceptuelle et méthodologique que représente l’étude de la mémoire de reconnaissance. Merci pour ta disponibilité et ta rigueur. Patrice Péran, hyper-présent tout le long de ce travail de thèse, et dont l’enthousiasme partagé comme le soutien dans les moments difficiles ont largement égalé l’aide précieuse sur les aspects théoriques, méthodologiques et d’analyse de la neuro-imagerie. Christopher Moulin pour les discussions passionnantes autour de la recognition memory mais pas seulement, merci pour les précieux conseils à des moments clés, pour ton soutien au moment du comité de suivi de thèse. Ravie de te connaître ! Pierre Celsis (Inserm UMR 825), Michèle Fabre-Thorpe puis Simon Thorpe (CerCo UMR 5549) pour m’avoir accueillie dans leurs unités respectives durant ces 3 ans. les membres de l’unité de neuropsychologie – ma « crèmerie » comme dirait Jean-Luc Nespoulous - pour leur soutien tout le long de mon cursus universitaire, leur veille pour le recrutement des patients et leur sollicitude. Catherine Bézy, Pauline Cazaux, Louise Derieux, Sybille Devrue, Béatrice Lemesle, Bérengère Pagès, Mélanie Planton, Thomas Busigny, Johanne Le Men, Céline Vervueren, Hélène Mirabel, Marion Sarrail, Mathilde Coustalat, Annick Celsis, Sabrina Conquet, Barbara Pech …j’ai hâte de vous retrouver ! l’équipe des médecins du service de neurologie et de neuro-vasculaire de l’hôpital Purpan (François Chollet) – Michèle Puel (merci pour les belles illustrations thalamiques et pour vos encouragements !), Jean-François Albucher (merci pour votre enthousiasme et vos relectures !), Nicolas Raposo, Blandine Acket, Virginie Sattler, Marie Lafuma, Jonathan Curot - pour leur implication dans le recrutement des patients thalamiques et pour les relectures de l’article. Igor Sibon (service de neurologie vasculaire, Bordeaux) pour avoir participé au recrutement et pour ses relectures. Fabrice Bonneville pour avoir éclairé certains aspects neuro-radiologiques de mes données, pour ses relectures et surtout pour m’avoir montré pour la première fois le tractus mamillo-thalamique sur un T1. Grand moment. Jean-Michel Hupé et Josette Pastor pour les éclairages statistiques. Merci... à la chouette bande de chouettes copains du labo, U825 et CerCo, (actuels et déjà doc voire post- doc, voire MCF… l’avantage d’être un « vieux » doctorant) pour leur soutien, leur écoute et leur propension au délire, les discussions enflammées du midi, les potes de galère du week-end à Baudot, 4 les bières au Vasco, les bulles, les nonnes et j’en passe… j’ai nommé Edward Collett, Pierre Eustache, Charlotte Dutilleul, Boris demain, Carole Davoust, Emilie Rigal, Mehdi Senoussi, Mélanie Planton, Déborah Méligne, Aurélie Pistono, Rodika Sokoliuk, Anne-Sophie Brun, Sophie Billoux, Perrine Bertrand, Mélanie Jucla, Marlène Poncet, Thomas Busigny, Jean Pellaprat, Djilali Adel, Federico Nemmi, Laure Saint-Aubert, Gabriel Besson. Merci aux autochtones de la coloc Sansou pour les truculentes soirées. Et un big up pour tous les autres étudiants, en M2 ou en thèse, à l’Inserm et au CerCo : courage les kids ! à Marlène Poncet, Thomas Busigny, Martin Deudon, Gabriel Besson, Djilali Adel, Mélanie Planton, Mehdi Senoussi, Edward Collett, Pierre Eustache pour les coups de main par-ci par-là, à des moments plus ou moins désespérés… Pour m’avoir aidé à écrire un script sur Matlab, relire un résumé en anglais, comprendre le pré-processing en IRMf, à double segmenter des toutes petites structures et parfois tout recommencer, double Fazekas & Schmidter, découvrir les stats de tout petits échantillons, comprendre pourquoi un script sur R ne marche plus alors qu’il marchait très bien l’année dernière mais qu’entre-temps je n’ai plus utilisé… Merci à Aicha Lyoubi, Jonathan Curot et Marie Lafuma pour avoir assuré les examens neurologiques de l’étude (c’est ainsi qu’on découvrit qu’un téléphone portable pouvait très bien faire l’affaire pour tester les ROT). Merci à Lucette Foltier, Jean-Pierre Désirat, Hélène Gros et Nathalie Vayssière pour leur aide et les bons moments partagés à l’IRM ! Merci à Maryline Calise pour ta patience et ta bonne humeur ! Merci à Marie Lafuma et Marie Charras pour les collaborations thalamo-volumétrique et thalamo-neuropsychiatrique passées et en cours. Remember : thalamus quand tu nous tiens… Loin d’être finie cette histoire ! Merci à Gabriel Danet (Agence de webdesign Blackbeans) pour le design de la charte graphique de mes magnifiques posters arborant un style très West coast scientific. Absolument hype. à mes amis qui m’ont témoigné un soutien sans faille et ont cru en moi depuis le début. Avant même le début pour certains… Merci à Soraya Bidjou, Leïla Ghouas et Johanna Stern, mon socle non- négociable et incomparable ; j’ai été modelée au fil des années par ces amitiés historiques que j’appellerais amitiés profondément « Self related ». Et puis en arrivant à Toulouse, à la fac d’orthophonie j’ai rencontré 4 super nanas : Alice Tessier, Anne Daurat, Clémentine Lanne et Julie Gornès, des filles vraiment géniales, drôles, libres et intègres avec qui j’ai partagé et partage des choses très fortes. Bdo vous remercie. Merci à Sebastien Puma et à Sophie Pourtanel pour les soirées en terrasse à refaire le monde, pour avoir toujours cru en moi. Et… les supporters de saint-Cyp ! The place to be évidemment, mes amis esthètes du quotidien, du caf post-marché dominical, des challenges de bouffe dangereuse, du Viêtnam, des récitals au château, et du bon goût en général : Mélanie Planton, Johanne Le Men, Thomas Busigny, Déborah Méligne, Jean Pellaprat, Tudi Gozé. Merci à Arnaud Javelle et à Sarah Fernandes pour les intermèdes gastro-littéraires, merci au récit régulier des aventures rafraîchissantes d’Aicha Lyoubi (par Aicha Lyoubi). à mon acolyte Mélanie Planton, mon alter-ego au travail et mon amie pour le reste. Merci pour ton écoute, ton enthousiasme et ta pugnacité, merci pour ton soutien. à mon noyau, ma famille : Alain, Agnès, Gabriel et Etienne Danet, là où tout s’explique, pour votre amour et votre soutien inconditionnels et précieux. à Grégoire Vilanova, Grand Maître Epicier-Ornithologue de ma vie, pour ton amour, ta finesse et ta curiosité inextinguible, tes multiples attentions et ton soutien de tous les instants, et ta nouvelle moustache. à la danse qui a eu un rôle particulièrement important ces trois dernières années, beaucoup plus que pendant les 23 autres ! Et à Nadine Sers, anthropologue de la danse et professeur inspirant. à tous les participants des études de cette thèse pour leur enthousiasme. à tous ceux qui ont croisé de près ou de loin ce travail de thèse ou ses à-côtés. 5 TABLE DES MATIÈRES Introduction générale ---------------------------------------------------------------------------------------------------------------------- 8 I. La recollection et la familiarité en mémoire de reconnaissance -------------------------------------------------- 12 I.1 Mémoire de reconnaissance --------------------------------------------------------------------------------------------- 12 I.1.1 Définition des processus de recollection et familiarité--------------------------------------------------------- 12 I.1.2 La mémoire de reconnaissance comme un système de détection du signal ----------------------------- 15 Signal detection theory (SDT) ----------------------------------------------------------------------------------------------------- 15 Threshold theory --------------------------------------------------------------------------------------------------------------------- 19 I.2 Recollection
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