BASFBASF PlantPlant ScienceScience –– FutureFuture ProductsProducts

EFSA Scientific Hearing 21st March 2007, Parma, Italy Christine Wandelt Regulatory Affairs BASF Plant Science BASF Plant Science – Future Products

„BASF Plant Science

„Project Portfolio

„Examples

„Conclusion

21st March 2007 2 BASF Plant Science BASF Plant Science

„ Focus: zMore efficient zBetter, healthier zRenewable resources – Plants as ‘Green’ Factories „ > 600 employees at 8 sites in 5 countries „ Partnership with seed companies „ Co-operations with universities and research institutes worldwide „ BASF Growth Cluster: 330 Mio. Euro R&D investments within the next three years

21st March 2007 3 BASF Plant Science BASF Plant Science Platform

BASF Plant Science North Carolina

BASF Plant Science Ames, Iowa

BASF Plant Science

BASF Plant Science Ludwigshafen

21st March 2007 4 BASF Plant Science BASF Plant Science – Future Products

„BASF Plant Science

„Project Portfolio

„Examples

„Conclusion

21st March 2007 5 BASF Plant Science Strategic Focus

Crop „ Nematode resistance More protection „ Herbicide tolerance Efficient „ Fungal resistance Agriculture Agronomic performance „ Yield increase „ Stress tolerance Feed Better, „ Amino acid profile value „ Phytate reduction Healthier „ Carotenoids Nutrition Food specialties „ Omega-3 fatty acids

Plants as Plant ingredients „ Amylopectin “Green” „ Amylose Factories for industrial use

21st March 2007 6 BASF Plant Science Development Timeline for GM crops

Gene Trait Trait Product Marketing Discovery Research Development Development / Sales

~ 2 years ~ 3 years ~ 3 years ~ 3-5 years

21st March 2007 7 BASF Plant Science BASF Plant Science – Future Products

„BASF Plant Science

„Project Portfolio

„Examples

„Conclusion

21st March 2007 8 BASF Plant Science More Efficient Agriculture: Phytophthora Resistant Potatoes „ Resistance genes from Solanum „ Complementing existing resistance gene reservoir „ Directed at commercial potato genetic background

21st March 2007 9 BASF Plant Science More Efficient Agriculture: Drought Tolerance

„ Explore existing gene Gene Proof Target pools e.g. in flowering Identification of Concept Crop plants, moss, algae, fungi „ Modulating gene expression e.g. transcription factors „ Potential target crops: Moss Trans- Parental wheat, oilseed rape, formants line maize, soybean

21st March 2007 10 BASF Plant Science Better, Healthier Nutrition: Omega-3 Fatty Acids Today „ Long-chain polyunsaturated fatty acids „ Explore metabolic pathways e.g. in Future plants, moss, algae, fungi „ Complementing Omega-3 existing fatty acid pathways genes „ Multi-gene constructs

21st March 2007 11 BASF Plant Science Plants as “Green” Factories: Optimized Potato Starch „ Modulate expression of genes in the starch metabolic pathway (down- regulate, RNAi) „ Analogous traits obtained via mutational breeding „ E.g. waxy maize, high-amylose maize

21st March 2007 12 BASF Plant Science BASF Plant Science – Future Products

„BASF Plant Science

„Project Portfolio

„Examples

„Conclusion

21st March 2007 13 BASF Plant Science Conclusion

„ Products in development z Complement or modulate plant biosynthetic pathways z Tools: familiar from plant defence mechanisms (R- genes, RNAi) and breeding (transcription factors) z Crops: wheat, potato, maize, soybean, oilseed rape „ Safety considerations z Comparative risk assessment approach applicable z Case-by-case z Bilateral discussions

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