RESEARCH ARTICLE Effects of antioxidant-rich foods on altitude- induced oxidative stress and inflammation in elite endurance athletes: A randomized controlled trial 1 2 2,3 1,4 Anu Elisa Koivisto , Thomas OlsenID , Ingvild Paur , Gøran Paulsen , Nasser Ezzatkhah Bastani2, Ina Garthe1, Truls Raastad4, Jason Matthews2, Rune Blomhoff2,3, Siv Kjølsrud Bøhn 2,5* a1111111111 ID a1111111111 1 Norwegian Olympic Sports Centre, Norwegian Olympic and Paralympic Committee and Confederation of a1111111111 Sports, Oslo, Norway, 2 Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, a1111111111 Oslo, Norway, 3 Division of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, a1111111111 Norway, 4 Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway, 5 Department of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås, Norway *
[email protected] OPEN ACCESS Citation: Koivisto AE, Olsen T, Paur I, Paulsen G, Abstract Bastani NE, Garthe I, et al. (2019) Effects of antioxidant-rich foods on altitude-induced oxidative stress and inflammation in elite endurance athletes: Background A randomized controlled trial. PLoS ONE 14(6): e0217895. https://doi.org/10.1371/journal. Various altitude training regimes, systematically used to improve oxygen carrying capacity pone.0217895 and sports performance, have been associated with increased oxidative stress and inflam- Editor: Cristina Vassalle, Fondazione Toscana mation. We investigated whether increased intake of common antioxidant-rich foods attenu- Gabriele Monasterio, ITALY ates these processes. Received: February 9, 2019 Accepted: May 17, 2019 Methods Published: June 13, 2019 In a randomized controlled trial, 31 elite endurance athletes (23 ± 5 years), ingested antioxi- dant-rich foods (n = 16), ( doubling their usual intake), or eucaloric control foods (n = 15) Copyright: © 2019 Koivisto et al.