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1H. Liver X Receptor-Like Receptors (Version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

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1H. Liver X Receptor-Like Receptors (Version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database IUPHAR/BPS Guide to Pharmacology CITE https://doi.org/10.2218/gtopdb/F89/2019.4 1H. Liver X receptor-like receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Donald P. McDonnell1 and Rachid Safi1 1. Duke University, USA Abstract Liver X and farnesoid X receptors (LXR and FXR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [68]) are members of a steroid analogue-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. Endogenous ligands for LXRs include hydroxycholesterols (OHC), while FXRs appear to be activated by bile acids. In humans and primates, NR1H5P is a pseudogene. However, in other mammals, it encodes a functional nuclear hormone receptor that appears to be involved in cholesterol biosynthesis [71]. Contents This is a citation summary for 1H. Liver X receptor-like receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links. GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts. Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators. Database links 1H. Liver X receptor-like receptors http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=89 Introduction to 1H. Liver X receptor-like receptors http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=89 Receptors Farnesoid X receptor http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=603 1 Farnesoid X receptor-β http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=604 Liver X receptor-α http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=602 Liver X receptor-β http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=601 References 1. Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, Rudling M, Angelin B, Björkhem I, Pettersson S and Gustafsson JA. 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Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, Plunket KD, Morgan DG, Beaudet EJ, Whitney KD, Kliewer SA and Willson TM. (2002) Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J. Med. Chem. 45: 1963-6 [PMID:11985463] 15. Costet P, Luo Y, Wang N and Tall AR. (2000) Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem. 275: 28240-5 [PMID:10858438] 16. Cui J, Huang L, Zhao A, Lew JL, Yu J, Sahoo S, Meinke PT, Royo I, Pelaez F and Wright SD. (2003) Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance 2 transcription of bile salt export pump. J. Biol. Chem. 278: 10214-20 [PMID:12525500] 17. Dalen KT, Ulven SM, Bamberg K, Gustafsson JA and Nebb HI. 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