117 the University at Stony Brook as well as by the School clinical affiliates of the Nassau University of Medical Center, Winthrop University Hospital, the Northport Veterans Affairs Medical Center, Medicine and various community clinical facilities integrated under a variety of arrangements. Dean: Norman H. Edelman

Vice Deans: Craig C. Malbon, scientific affairs; Peter C. Admission to the MD Program Williams, academic affairs and faculty development The Medical College Admission Test (MCAT) must be taken no later than the year prior to the year for which the student seeks Associate Deans: Thomas Biancaniello, medical affairs; Jack admission. By law, applicants must have completed a mini- Fuhrer, admissions; Frederick M. Schiavone, medical educa- mum of two years of college before matriculation; however, tion; Aldustus Jordan, student and minority affairs; Michael L. medical school admissions committees favor applicants with Rainey, academic advising; Dorothy S. Lane, continuing med- more complete educational preparation. Premedical course ical education; Derinda Pell, administration and finance. requirements include one year each of biology, physics, inor- ganic chemistry and organic chemistry (all with lab), and one Associate Deans for clinical affiliations: John F. Aloia, Winthrop year of English. A basic course in biochemistry is helpful in University Hospital; Edward J.C. Mack, Veterans Affairs Med- preparing students for the first year of medical school; howev- ical Centerat Northport; Michael Mastow, Nassau University er, it is neither a requirement nor a criterion for admission. Medical Center. The school hopes to acquire a student body representative of a variety of backgrounds, experiences, and interests. The school examines rigorously the preparation and promise for Assistant Dean: Grace Agnetti, Marilyn London creative work in medicine of all applicants, and asks to meet personally with those in whom it is most seriously interested. Executive Assistant to the Dean: Barbara E. Katz Although it is desired that many backgrounds are represented in the student body, the school does not attempt to maintain a Assistants to the Dean: Mary Jean Allen, Marilyn DuBritz, Burke quota to fill any one “category” of student. It does, however, Kincaid, Marilyn London, Judy Lum, John Riley want to make clear its commitment to seek a significant repre- sentation in its student body from groups who have long The School of Medicine consists of basic science and clinical remained under-represented in medicine. departments that have the responsibility for pre-clinical and Grades, MCAT scores, letters of evaluation, extracurricular clinical instruction of students in all the schools of the Health and work experiences are carefully and personally examined. Sciences Center as well as university-wide responsibility to Motivational and personal characteristics, as indicated in an students in other schools on the campus. Basic science depart- individual’s application, letters of evaluation, and a personal ments include the departments of anatomical sciences, bio- interview, are also a major part of the admissions assessment*. chemistry and cell biology, biomedical engineering, microbiol- Decisions will be influenced by an applicant’s scholarship, ogy, neurobiology and behavior, pathology, pharmacological aptitude, character, personal qualities, and promise of future sciences, and physiology and biophysics. Clinical departments value to society through the medical profession. There is no include the departments of anesthesiology, dermatology, emer- discrimination in the admissions review and selection process gency medicine, family medicine, medicine, neuro l o g i c a l on the basis of sex, race, religion, national origin, age, marital surgery, neurology, obstetrics, gynecology and reproductive status, or disability. Residents of New York State constitute the medicine, ophthalmology, orthopaedics, pediatrics, physical majority of the applicant pool and a great majority of the medicine and rehabilitation, preventive medicine, psychiatry entrants; however, applications for the MD/PhD program are and behavioral science, radiation oncology, radiology, surgery, encouraged from both in-state and out-of-state applicants and and urology. from under-represented minorities. In addition to instruction at the undergraduate and profes- sional levels, these departments have major responsibility for All questions concerning admission should be addressed to: graduate, postgraduate, and continuing education. The goal of Office of Admissions, School of Medicine each of these departments is to: Health Science Center, Room 046, Level 4 1) integrate as rapidly as possible new Stony Brook University scientific knowledge and the advances of Stony Brook, NY 11794-8434. basic re s e a rch into the training of every Telephone: (631) 444-2113 health professional 2) promote input from all university disciplines Applications are available through the American Medical Col- into education and re s e a rch in the health leges Application Service (AMCAS). sciences 3) e n s u re that every healthcare professional trained in the school is prepared to provide the highest level of patient care. In the basic sciences, these efforts are enhanced by col- laboration with colleagues at the biology and medical departments of the Brookhaven ______*The submission of false or misleading information in the application National Laboratory, the Cold Spring Harbor materials or in connection with the application process shall be grou n d s Laboratory, and other research institutions in the for rej e c t i o n . If such submission is discovered after the rendering of an v i c i n i t y. In the clinical departments, these of fer of admission, matriculation in the school, or award of the degree, it objectives are enhanced by the Medical Center of shall be grounds for withdrawal of the acceptance offe r , for dismissal, or for revocation of degree .

118 Technical Standards for Admission and Retention ship in medicine; eight-week clerkships in pediatrics and The MD degree is, and must remain, a broad undifferentiated s u rgery; six-week clerkships in obstetrics-gynecology, and degree attesting to the mastery of general knowledge in all family medicine; a four-week clerkship in psychiatry and two- fields requisite for entry into graduate medical education pro- week clerkships in radiology and emergency medicine. grams (residencies) of diverse types. It follows that graduates The fourth-year curriculum consists of the following must possess the essential knowledge and skills to function in requirements: a broad variety of clinical situations, and to render a wide spec- trum of patient care in a safe and effective manner. 1. A one month subinternship (medicine, family The School of Medicine faculty has, therefore, specified non- medicine, pediatric or general surgery) academic criteria, Technical Standards for Admission and 2. A one-month didactic course (emergency Retention, which all applicants/medical students are expected medicine, laboratory medicine, clinical therapeutics to meet in order to participate in the medical education pro- or surgical anatomy) grams. These criteria include the following five categories: 1) 3. A Medicine in Contemporary Society requirement observation; 2) communication; 3) motor skills; 4) intellectual- 4. A one-month neurology experience conceptual, integrative and quantitative abilities; and 5) behav- 5. A two-week experience in Psychiatry in Medicine ioral and social attributes. A copy of the Technical Standards 6. A one-month experience in Surgical Selectives may be obtained from the Admissions Office. 7. Students must complete three (3) and one half months of electives Grading Policy The School of Medicine does not assign specific credits to med- During the four years, a student’s acquisition of clinical and ical student courses. Students must complete the entire cur- laboratory skills necessitates attendance and demonstration of riculum successfully to graduate. Students are graded H (Hon- competence at patient-contact exercises and laboratories. Pass- ors), P (Pass), or F (Fail). Other grades used are I (Incomplete), ing USMLE Step 1 and Step 2 is required for promotion and an interim grade that must be resolved before the beginning of graduation. the next academic year; and W (Withdrawal). Although the official transcript lists only the grades above, our internal MD/PhD Program records list high pass (HP) and low pass (LP) as well. The MD/PhD program normally requires six to eight years to complete. During the first two years, the MD/PhD curriculum Alpha Omega Alpha closely follows the MD curriculum, with the addition of basic A chapter of Alpha Omega Alpha, the national honor medical science tutorials during the first year, and two summers of lab- society, was established at the School of Medicine in 1985. The oratory research. The next two to four years are spent complet- society’s purpose is to recognize and perpetuate excellence in ing the requirements for the PhD in a basic science. To be the medical profession. Each year member chapters elect out- awarded the PhD degree, the student must satisfy the Gradu- standing medical students, graduates, faculty and honorary ate School and Basic Health Science Graduate Studies require- members to its ranks. ments. At the conclusion of the research period, MD/PhD can- didates complete medical school clerkships, selectives and MD Curriculum electives required for the awarding of the MD degree. The MD curriculum in the school is a series of courses offered by individual departments or integrated units that are planned MD With Recognition in Research Program and taught in an interdisciplinary manner by faculty from Students must complete six months of research during medical many departments. school and present their results at a student research seminar The first year curriculum consists of basic science courses and in their senior year. introductory courses related to patient care. Basic Science courses include: Molecules, Genes and Cells; The Body; Neu- MD With Recognition in Medical Humanities rosciences; Nutrition; Medical Physiology; and Pathology. This program is structured within the four-year medical school Other required courses are Medicine in Contemporary Society, framework. During medical school, students in this program a course that spans all four years and contains components of complete six months of scholarly activity with the faculty of Social Issues in Medicine, Ethics, Law, and Health Economics; the Institute for Medicine in Contemporary Society. Preventive Medicine, Introduction to Human Behavior; Basic Life Support, including Cardiopulmonary Resuscitation (CPR) leading to certification in CPR; and Introduction to Clinical Scholars for Medicine (BA/MD Program) Medicine, a two-part course, spanning the latter half of both Scholars for Medicine will earn a BA/MD degree with four the first and second years, which introduces history taking and years of undergraduate course work and four years of medical physical examination skills. school. All Scholars of Medicine will be individually counseled The second-year curriculum contains the study of organ on their careers throughout their participation in the program. pathophysiology in the Systems Approach to Medicine course. Benefits include full or partial scholarship funds, help in find- This course consists of integrated presentations of basic and ing laboratory placements for undergraduate research projects, clinical science. It includes coverage of neurosciences, blood, regular advising from both the Honors College Master and the cardiovascular, endocrine, gastrointestinal, connective tissue, P remedical A d v i s o r, opportunities to meet faculty in the renal, reproductive, and respiratory systems. In addition, Phar- School of Medicine, seminar participation with invited guest macology and Microbiology courses are included in the sec- speakers in the Scholars for Medicine Lecture Series, and sup- ond-year curriculum. The Introduction to Clinical Medicine port and encouragement in the exploration of undergraduate course, in the second year, fosters development of patient inter- and career opportunities. view, examination and correlative skills as the student acquires Scholars for Medicine positions will be available to select additional knowledge of physiology, pathology, and the entering freshmen who have been accepted to the Honors Col- natural history of diseases with the systems course. lege Program. Eligibility criteria are: nomination of high school The third-year curriculum consists of a twelve-week clerk-

119 seniors by the Honors College; 1350 or above on the SATs; ic dishonesty. There is a discussion of professionalism in the maturity; evidence of social commitment; evidence of interest school’s Policies and Procedures and students are evaluated in science; high moral character; breadth of interests and strong for professionalism in their course work using a form that communication skills. specifies elements of personal responsibility, cultural sensitivi- All acceptances to the Scholars of Medicine Pro g r a m ty, self-improvement, integrity and altruism. There is also a (BA/MD Program) are conditional. Of critical importance will student honor code created by the students to which all med- be an ongoing assessment of the candidate’s maturity, academ- ical students must adhere. ic ability and his/her motivation and readiness to pursue a Violations of the student honor code are reviewed by a stu- medical education. Scholars must continue to present exem- dent committee which reports recommendations to the dean. plary academic accomplishments and those personal charac- In cases of academic difficulty or dishonesty, the student is teristics that exemplify a Scholar for Medicine. Students must offered an opportunity to appear before the Committee on accrue a GPA of 3.4 during the first three undergraduate years. Academic Standing. Decisions of this committee are reported All scholars will be required to take the MCAT no later than to and may be appealed to the Dean of Medicine. spring of their junior year in college. Students need to attain Students with learning or other disabilities will be evaluat- cumulative MCAT scores comparable to the national average ed by the University’s Disability Support Services and, in dis- of matriculants to medical school. All scholars must attend cussion with the dean’s office, appropriate accommodations Scholars for Medicine lectures and seminars, and prepare made. assignments as required. Scholars for Medicine accepted into the BA/MD program Graduate Studies in Basic Health Sciences before matriculating at Stony Brook will have a place reserved Graduate studies leading to the PhD degree in basic health sci- in Stony Brook Medical School contingent upon the above cri- ences are offered in the fields of anatomical sciences, molecular teria. Final acceptance will be placed on the ongoing evalua- microbiology, cellular and molecular pathology, molecular and tions by program advisors, letters of evaluation, MCAT perfor- cellular pharmacology, or physiology and biophysics. The mance, and an interview with the Committee on Admissions of department of oral biology and pathology also offers a Master the School of Medicine. All students in the BA/MD program of Science degree in Basic Health Sciences. must apply for early decision to Stony Brook School of Medi- Basic health sciences departments of the School of Medicine cine. also collaborate with the Division of Biological Sciences and other academic units to operate graduate study programs in Institute for Medicine in Contemporary Society various areas of the biological sciences, such as molecular biol- The Institute for Medicine in Contemporary Society was estab- ogy and biochemistry, cellular and developmental biology, lished in 1990 at the School of Medicine to develop interdisci- genetics, and neurobiology and behavior. plinary programs that explore the relationship of medicine to Each graduate studies program is guided by its own director other dimensions of contemporary culture. Philosophy, law, and executive committee and establishes its own entrance stan- the arts, social sciences, literature, and religion all have signifi- dards and degree requirements, described in detail in the cant roles to play in reflecting on the insights into ourselves Graduate Bulletin. Inquiries regarding graduate admission to a which arise from studying the complex experience of being ill specific department should be addressed to the director of the and caring for the ill. With a primary interest in connecting the department’s graduate program. Please see the “Admissions schools of the Health Sciences Center, other departments of the Section” in this Bulletin for more information. university and the Long Island community, the Institute serves as a catalyst for discussion, educational experiment, and Financial Aid research in the multi-cultural environment of Stony Brook. Inquiries concerning these and other sources of financial aid should be directed to the School of Medicine financial aid offi- Academic Standing cer. For additional financial data, refer to the “Financial Assis- It is the intention of the School of Medicine to assure that stu- tance” section at the beginning of this Bulletin. dents are adequately prepared, both for the practice of medi- cine and a life in medicine. Such assurance requires both an School of Medicine Chairs and Visiting overall academic performance that goes beyond merely mar- Professorships ginal and an unblemished record of professionalism. Different courses have different requirements, but in all The Edmund D. Pellegrino Professorship of Medicine courses, grades are determined by course directors and report- In 1986, the university established a professorship in the School ed to the Office of Office of Medical Education (OME) and the of Medicine to honor Edmund D. Pellegrino, MD, founder of Committee on Academic Standing, the body charged with the Health Sciences Center. The endowment specifies that the oversight of student progress. Students must complete all Edmund D. Pellegrino Professorship of Medicine will be occu- coursework in one year before proceeding to the next. More- pied by “an individual who exemplifies the breadth of interests over, students must pass USMLE, Step 1 before continuing in and achievements in education, research, and the practice of the third year, and must pass Step 2 to graduate. medicine that have characterized Dr. Pellegrino’s career.” The The Committee on Academic Standing also evaluates first occupant of that chair was Dr. Pellegrino, who held it for reports of professional misconduct and makes recommenda- a brief period. Following Dr. Pellegrino’s tenure, the chair was tions to the dean. The School of Medicine’s policy is to ensure occupied by Harry W. Fritts, MD, who is now the Pellegrino the integrity of its examination process, to promote ethical Professor Emeritus and former chairman of medicine at Stony behavior in academic and clinical situations, and to develop in Brook. Currently, Benjamin J. Luft MD, professor of medicine, students a commitment to the integrity of the medical profes- occupies the chair. sion. Students have an obligation to refrain from any act that is designed to obtain for themselves or others academic credit, The Evelyn Glick Chair in Experimental Medicine grades, or other recognition which is not properly earned. In 1990, Mrs. Evelyn Grollman Glick of Baltimore, Maryland, They also have an obligation to take an active role in ensuring created an endowment designed to support a Chair in the that other students refrain from such acts. Each student there- Department of Pharmacological Sciences. Income from this fore has the responsibility to prevent or report acts of academ- fund provides research or salary support for the Chair. The

120 current occupant of the chair is Arthur P. Grollman, MD, Lead- in the Health Sciences Center or the Stony Brook University ing Professor of Pharmacological Sciences and Professor of Hospital, please call 631.444.7916. For more information Medicine. about alumni activities, please call 631.444.2988, or log onto the website http://www.hscalumni.stonybrook.edu. The Marvin Kuschner Professorship of Pathology An endowed chair in the School of Medicine, The Marvin Grants and Awards Kuschner Professorship of Pathology was established by the University in 1988 in honor of Marvin Kuschner, MD, dean The Arthur Berken Fellowship emeritus of the School of Medicine at Stony Brook. The endow- Dr. Arthur Berken, a long-time member of the clinical faculty at ment specifies that the “Marvin Kuschner Professorship of the School of Medicine, always worried about the impact of Pathology will be occupied by an individual who exemplifies technology on men and women in medical school. With the the breadth of interests and achievements in education, advances in diagnostics and treatment made possible through research and the practice of pathology and environmental technology, he feared that young doctors might come to see medicine that have characterized Dr. Kuschner’s career.” Fred- their patients as little more than biochemical machines. And, so erick Miller, MD, professor of pathology, currently occupies when Dr. Berken passed away in the late spring of 1994, his this chair. wife Roberta, his family and a number of friends and col- leagues decided to endow a fellowship that would encourage The Leo and Judy Zickler Visiting Professorship in Phar- would-be physicians to remember that, in the end, it is people macological Sciences who matter most. The Arthur Berken Fellowship has made A Visiting Professorship in Pharmacological Sciences was possible a new addition to the School of Medicine’s MD with established in 1988 through a gift from Leo and Judy Zickler of Recognition Awards, an MD with Recognition in Medical Bethesda, Maryland. Under the terms of this endowment, a Humanism. distinguished scientist is invited to spend up to five days at the University at Stony Brook, to engage in teaching and discus- Sir James Black Award for Excellence in Research sion with faculty and students. During the visit, the professor An endowment has been established with a gift from Sir James delivers a general lecture on a subject of his choice. Zickler Vis- Black, FRS, Nobel Laureate in Physiology or Medicine, to pro- iting Professors have included Daniel Nathans, Howard vide an award to the graduating undergraduate pharmacology Temin, Gobind Khorana, Victor McKusick, Sydney Brenner, major who has achieved the highest scholastic excellence in Leroy Hood, Dirk Boostma, Sir James Black, Alfred G. Gilman both course work and a senior research project. and Joseph L. Goldstein. The Catacosinos Cancer Awards Advancement Dr. and Mrs. William Catacosinos have generously donated The strength of the synergistic relationship between the funds for annual grants to support cancer research. The Cata- schools of the Health Sciences Center and the Stony Brook cosinos Cancer Award recognizes significant contributions to University Hospital is the basis for a new approach being the illumination of the cancer problems of the past and antici- taken toward institutional advancement. The hallmarks of pates major advances coming from these investigations. A this approach are an emphasis on fundraising, marketing, and committee of scientists, appointed by the Dean of Medicine, communicating with alumni, corporations, private founda- oversees these awards which are administered by the Stony tions, and the community. The goal for the new office is to Brook Foundation. obtain philanthropic support that will enable the HSC and SBUH to continue their tradition of excellence in medical care, Jean M. Devlin Achievement Award research, education, and community service. This endowment, created by generous gifts from Richard A. Auhll and Rudi R. Schulte of Santa Barbara, California, In addition, the five schools of the Health Sciences are also matched by the Department of Pharmacological Sciences, hon- reaching out to alumni like never before. The Stony Brook ors Jean M. Devlin, founding Director of Stony Brook’s under- Alumni Association works to increase communication, graduate program in pharmacology. The Jean M. Devlin encourage involvement, and expand services for alumni, Award is presented at commencement to the graduating phar- while building support for the University. A volunteer Board macology major judged to have the greatest potential for mak- of Directors governs the Stony Brook Alumni Association ing future contributions to the pharmacological sciences. which represents the 110,000 alumni, including more than 15,000 alumni from the schools in the Health Sciences Center. Radmila and Gabor Inke Anatomical Research Fund The Department of Anatomical Sciences at University Medical There are five alumni chapters in the Health Sciences Center – Center Stony Brook is the beneficiary of a generous testamen- one for each of the schools. Each chapter has its own elected tary gift from Dr. Gabor Inke. Dr. Inke became the Depart- alumni board of directors, chapter membership, and hosts its ment’s first member in 1969 and served the Medical Center for own special events, besides participating at those that are uni- more than 20 years. Dr. Inke, a recognized expert on the devel- versity-wide, such as Homecoming and Alumni Weekend. opment of the human skull as well as the kidney, dedicated his life to research and teaching. Upon his death the Radmila and The alumni chapters strengthen the relationship between the Gabor Inke Anatomical Research Endowment Fund was creat- graduates and the schools in the Health Sciences Center by ed to support the research mission of the department that he providing ongoing support for alumni career development. helped to create. In response, this relationship allows the alumni to participate in school and university affairs and to contribute to the finan- William G. Van der Kloot Awards cial strength of the university through donation, endow- An endowment has been established by Professor Robert ments, and participation at special fundraising events. Nathans and the Department of Pharmacological Sciences in honor of William G. Van der Kloot, PhD, Professor of Physiol- For more information about making a contribution to a school ogy and Pharmacological Sciences, and founding Chair of the

121 Department of Physiology. The endowment provides awards HB A 393, 394 Special Topics from the Anatomical Sciences annually to two students in the molecular and cellular phar- Li t e r a t u r e macology graduate program. The Van der Kloot Teaching Tutorial readings in anatomical sciences with periodic conferen c e s , Award recognizes the most significant teaching contributions reports and examinations arranged with the instruc t o r . Open to junior or senior students. to the undergraduate major. The Van der Kloot Research Pre re q u i s i t e : Permission of instruc t o r . Award recognizes outstanding accomplishments in research. Variable credits, 1-2 per term, fall and spring terms, staff

Emil C. Voll Bequest HB A 398, 399 Research Projects in Anatomical Sciences A bequest of more than $1.7 million from Emil C. Voll was An independent res e a r ch project under faculty supervision emphasizes made in 1992 to fund a professorship in cancer research in the the principles of experimental design, data collection, evaluation of find- School of Medicine. Mr. Voll’s wife, Geraldine, died of cancer ings, and reporting of results. Project report req u i r ed. May be rep e a t e d . in 1987. Awards to four faculty investigators enable them to Pre re q u i s i t e s : Laboratory experience and permission of instruc t o r . play a major leadership role in the school of Medicine’s cancer 2-4 credits per term, fall and spring terms, staff program. HB A 46 1 Regional Human Anatomy An overview of the gross anatomy of the human body. Studies the limbs Continuing Medical Education in an extra period. Includes neuroa n a t o m y . Lectures and laboratory dis- The educational mission of the medical school lies in three se c t i o n s . areas of physician education. These are the education of med- Pre re q u i s i t e : Permission of instructor for non-Health Sciences students. ical students, residency training and the continuing education 5 credits, summer modules, Dr. Demes of physicians. This is consonant with the philosophy that edu- cation is a continuing process throughout a professional career. HB A 52 1 Gross Anatomy of Head, Neck and Tru n k The School of Medicine’s continuing education program is Tutorial laboratories. Emphasizes dissections of the human head, neck and trun k . accredited by the Accreditation Council for Continuing Med- Pre re q u i s i t e : Permission of instruc t o r . ical Education. Some 30,000 physician education hours are pro- 4 credits, fall modules, Dr. Krause vided each year through sponsored and jointly sponsored pro- grams. In addition to the programs prepared for presentation HB A 52 2 Human Embryology for Dental Students at the Health Sciences Center, faculty also present courses at The development of human struc t u r e with emphasis on normal adult community hospitals in the bi-county region. anatomy and the more common congenital anomalies, particularly those of the head and neck. Covers the events of early embryonic formation and subsequent oranogenesis, excluding that of the urog e n i t a l s y s t e m . Department of Anatomical Sciences Pre re q u i s i t e : H B A5 2 1 1 credit, fall term, Dr. Krause

Chair: Jack T. Stern HB A 53 1 The Body Ale c t u r e and laboratory with emphasis on dissection of the entire human Professors: Peter R. Brink (joint), Brigitte Demes, Leland H. bo d y . Includes functional and topographic anatomy, embryology, clinical Edmunds, Jr., John G. Fleagle, Frederick E. Grine ( joint), co r r elations and an introduction to radiology. Francoise Jouffroy (adjunct), David W. Krause, William L. Pre re q u i s i t e : Permission of instruc t o r . Jungers, Susan G. Larson, Lawrence Martin (joint), Russell A. 8 credits, fall modules, Dr. Stern Mittermeier (adjunct), Clinton Rubin (joint), Jack T. Stern, Jr., Randall L. Susman, David L. Williamson, Emeritus HB A 53 6 Biological Clocks Considers the temporal dimension of biological organization and of peri- odic phenomena that are a basic property of living systems. Top i c s Associate professors: Diane Doran (joint), Catherine Forster, include a survey of circadian rhythms; influence of light, temperature Callum Ross and chemicals; use of the clock for adaptation to diurnal, tidal and lunar cycles, for direction-finding (homing and orientation) and for day-length Assistant professors: Maureen O’Leary, Scott Sampson (adjunct) me a s u r ement (photoperiodism); chronopathology and chron o p h a r m a - cology; aging and life cycle clocks; possible molecular mechanisms of the Post Doctoral Associate: Kristian Carlson clock. Cross-listed with BCD 536. Pre re q u i s i t e : Permission of instruc t o r . The department conducts graduate studies leading to the 3 credits, spring term, Dr. Edmunds PhD. degree, through its own and interdisciplinary programs. HB A 53 7 Physiology and Biochemistry of the Cell Cycle It also provides instruction in the anatomical sciences for stu- An integrated view of the cell developmental cycle in prokaryotes and dents in the Schools of Health Technology and Management, eukaryotes. Topics include cell cycle anatomy; measurements on fixed Dental Medicine, Medicine, and Nursing. In addition, the and living cells; kinetics of cell population growth; theory and methodol- department participates in the teaching of undergraduates in ogy of batch, synchronized and continuous cultures; general patterns of biology, anthropology, and art. nucleic acid synthesis; regulation of enzyme activity during the cell cycle; temporal control of gene expression; development and function of cellu- Courses lar organelles during the cell cycle; and the control of cell division. Cros s - listed with BCD 537. HB A 109 Life through Tim e Pre re q u i s i t e : Permission of instruc t o r . An examination of biodiversity as presented in the fossil rec o r d and how 3 credits, fall term, Dr. Edmunds it contributes to the understanding of evolution. Species examined include invertebrates, plants, dinosaurs, paleontology, phylogeny rec o n - HB A 54 1 Evolutionary Anatomy st r uction, and conservation will be discussed. A le c t u r e and laboratory with emphasis on dissection of the entire human 3 Credits, Fall, Dr. O’ Le a r y bo d y . Includes functional and comparative anatomy with special empha- sis on the musculoskeletal morphology of humans and higher primates. HB A 36 0 Regional Human Anatomy Pre re q u i s i t e : Permission of instruc t o r An introduction to gross struc t u r e of the human head, neck and trun k . 8 credits, fall term, Dr. Jungers Includes neuroa n a t o m y . Lectures and laboratory dissections. Pre re q u i s i t e : Permission of instructor for non-Health Sciences students. Variable credits, 1-2 per term, fall term, staff 122 HB A 55 0 Vertebrate Paleontology HB A 58 2 Comparative Anatomy of Primates Survey of the fossil rec o r d of vertebrate evolution. The course empha- Laboratory dissection that emphasizes relating structural diversity to sizes the origin, phylogeny, comparative and functional morphology, bio- behavior and biometrics. ge o g r a p h y , and paleontology of vertebrate animals. Laboratory included. Pre re q u i s i t e s : HB A 564 and previous course in human or vertebrate anato- The lectures and laboratories will utilize an extensive collection of com- my and permission of instruc t o r . parative anatomical material, fossil casts, and slides. 4 credits, alternate spring term, Dr. Fleagle Pre re q u i s i t e : Pr evious course in human or vertebrate anatomy and per- mission of instruc t o r . 4 credits, spring term, alternate years, ABCF grading HB A 59 0 Projects in Anatomical Sciences HB A 56 0 Advanced Regional Anatomy Individual laboratory projects closely supervised by faculty members to Advanced human gross anatomy for graduate students or advanced be carried out in staff res e a r ch laboratories. un d e r graduates in biology, anthropology and other life sciences. Pre re q u i s i t e : Permission of instruc t o r . Pre re q u i s i t e : Permission of instruc t o r . 1-6 credits per term, fall and spring terms, staff Variable credits, 3-8 per term, spring term, Dr. Fleagle HB A 69 0 Graduate Seminar HB A 56 3 Aspects of Animal Mechanics Seminars by graduate students on current literature in the areas of the An introduction to biomechanics. Covers free-body mechanics and kinet- anatomical sciences. ics as applied to vertebrate locomotion. Also covers scaling, stress and Pre re q u i s i t e : Permission of instruc t o r . strain, and muscle physiology as these topics relate to adaptations of the 1 credit, fall and spring terms, staff musculoskeletal system. Pre re q u i s i t e : In t r oductory physics and biology or permission of instruc t o r . HB A 69 2 Advanced Topics in Anatomical Sciences 2 credits, spring term, alternate (odd) years, Drs. Stern, Jungers and Demes Li t e r a t u r e Tutorial readings in anatomical sciences with periodic conferen c e s , HB A 56 4 Primate Evolution reports and examinations arranged with the instruc t o r . The taxonomic relationships of the primates and evolutionary history as Pre r equisite: Permission of instruc t o r . documented by the fossil rec o r d and structural and chemical evidence. Variable and repetitive credits, 1-2 per term, fall and spring terms, staff Emphasizes primates prior to the origin of the human lineage. Laborato- ry included. Open to senior undergr a d u a t e s . HB A 69 5 Practicum in Tea c h i n g Pre re q u i s i t e : Permission of instruc t o r . Practical instruction in the teaching of anatomical sciences carried out 4 credits, spring term, alternate years, Dr. Fleagle under faculty supervision. Pre re q u i s i t e : Permission of instruc t o r . HB A 56 5 Human Evolution Variable and repetitive credits, 1-4 per term, fall and spring terms, staff Surveys the fossil rec o r d of human evolution from the later Ter t i a r y th r ough the Pleistocene with emphasis on the rec o r d of morphological HB A 69 9 Dissertation Research evolution including evolution of the skull, teeth and limbs. Includes the Original investigation under supervision of thesis adviser and commit- ape-human furcation, radiation of the early hominids, the evolution of te e . Homo Erectus, Neanderthal man, later human ancestors, the evolution of Pre r equisite: Permission of thesis adviser. the brain and intelligence, bipedalism and other morphological complex- Variable and repetitive credits, 1-9 per term, fall and spring terms, staff es. Utilization of comparative anatomical material, fossil casts, and slide collection. Cross-listed with ANT 565. HB A 80 0 Fu l l - T ime Summer Research Pre r equisite: Permission of instruc t o r . Full-time laboratory res e a r ch projects supervised by staff members. 4 credits, fall term, alternate years, Dr. Grine Pre re q u i s i t e : Permission of instructor and full- time graduate student sta- tu s . HB A 56 6 Studies in Functional Morphology 0 credit, summer term, staff In t r oduces the theory and methods of functional morphology. Covers various methods of analysis and the application of experimental tech- niques such as electromyography or bone strain analysis as they pertain Department of Anesthesiology to the understanding of the interaction between form and function. Emphasizes the analysis of human and non-human primate morphology, Chair: Peter S. Glass and its application to the interpretation of fossil evidence for human and non-human primate evolution. Pre r equisite: Permission of instruc t o r Professors: Helene Benveniste, Peter S. Glass, Robert I. Katz, Ira 2 credits, spring term, alternate (even) years. Dr. Larson Rampil, Stephen A. Vitkun

HB A 58 0 Comparative Anatomy and Evolution of Associate professors: W.W. Backus, James P. Dilger, F. Barry Flo- Ma m m a l s rence, John S. Gage, Maria L. G. Lagade, Farrokh R. Maneksha, The comparative anatomy, evolutionary history and radiation of fossil Bharathi H. Scott, Mario J. Rebecchi, Kenneth Rosenfeld, Ellen and living mammals. A major res e a r ch project on any aspect of mam- Steinberg malian comparative anatomy is req u i r ed. Supplemented by lectures on the evolutionary history and radiation of mammals. Comparative osteo- Assistant professors: logical and fossil cast collections will be utilized. Lecture series can be Rishimani S. Adsumelli, Carole W. Agin, taken separately as HBA 58 1 . Nelson, Barcelone, Lauren H. Fleischer, Abdel A. Graber, Xiao- Pre re q u i s i t e s : Pr evious course in human or vertebrate anatomy and per- jun Guo, Anthony Ippolito, Ronald C. Jasiewicz, Roseline mission of instruc t o r . Jerome, Ursula Landman, Josette Legaspi-Tamayo, Bo Liu, 4 credits, spring term, alternate years, Dr. Krause Irina Lokshina, Daryn Moller, S. Peter Oleszak, Srinivas Pentyala, John A. Petrie, Martin Redmond, Laura J. Reid, HB A 58 1 Evolution of Mammals Eleanor Romano, Mihai Sadean, Tracie A. Saunders, Joy E. Sch- The evolutionary history and radiation of mammals from the Mesozoic abel, Francis Stellaccio, Syed Y. Shah, Andrea K. Voutsas, Paul to the present from a paleontological and anatomical perspective. Willoughby Emphasizes the origin of mammals and the origin, evolution and anatomical diversity of modern and extinct orders of mammals. The department of anesthesiology provides instruction in the Pre re q u i s i t e s : Pr evious course in human or vertebrate anatomy and per- clinical science of the specialty, and the physiology, pharma- mission of instruc t o r cology, and biochemistry on which it is founded. Emphasis is 2 credits, spring term, alternate years, Dr. Krause placed upon the integration of basic and clinical sciences and upon an interdisciplinary approach to attain optimal care of

123 patients. Instruction is provided to medical and dental stu- MC B 52 9 Organelle Development dents in the second year of training and during their clinical Covers the development of the mitochondrion and the chlorop l a s t . clerkship. All students rotate through anesthesiology for two Includes the biogenesis of these organelles and their relation to the inter- weeks during their surgery selective month. Those students action with the nucleus. Emphasizes genetic and biochemical analysis. 3 credits, fall term, alternate years, Dr. Lym a n interested in more advanced training are encouraged to apply for a third year elective or a fourth year sub-internship, during MC B 65 6 Cell Biology which they will be exposed to all aspects of clinical anesthesia In t r oduces the structural and functional organization of cells and tissues management of surgical and obstetrical patients. They will and the way struc t u r e relates to function. Emphasizes cell organelle struc - administer anesthesia under supervision, participate in pre- tu r e and function in specialized cells in tissues. The organization and and post-operative care, and become familiar with specialized interaction of cells in tissues also covered. The course is comparative and aspects, such as intensive care, cardio-pulmonary resuscita- includes examples of tissues from vertebrates, invertebrates, and plant tion, cardiac and neurosurgical anesthesia, perinatal medicine, pr okaryotic systems. Cross-listed with HBA 65 6 . and the therapy of acute and chronic pain. Participation in 4 credits, spring term, Dr. Lym a n ongoing clinical research projects and all teaching exercises is MC B 657 Principles of Development encouraged. Covers developing systems at all levels from the morphological to the In its graduate program, the department provides a three- molecular. Illustrative material from both animal and plant kingdoms year training program of residents specializing in anesthesiol- are used. Special attention given to gametogenesis, genetic control of ogy, following completion of a basic first year of postgraduate early development, transcriptional and translational control of protein training. It offers clinical electives of two- to twelve-month synthesis, the role of cell division and cell movements, and cell-to-cell duration to medical and dental house officers in other special- interactions in defining developing systems. Cross-listed with HBA ties. 657. Fellowships in subspecialties and clinical research are avail- Prerequisite: BCD 657 3 credits, fall, Dr. Lyman able to physicians who have completed the requirements toward specialization. MC B 500 Directed Readings in Molecular Biology Directed readings in topics of current interest, under supervision of a faculty sponsor culminating in one or more critical review papers. Department of Biochemistry and Cell Biology Prerequisites: Sponsor and approval of Master’s Program Executive Committee Chair: William J. Lennarz 1-3 credits, yearly, faculty MC B 503 Molecular Genetics Professors: Bernard S. Dudock, Peter Gergen, Masayori Inouye, Covers gene structure and regulation in prokaryoltic and eukaryotic (adjunct), William Lennarz, Erwin London, Kenneth Marcu, organisms, mutational analysis and mapping, transposable elements Nisson Schechter, Jakob H. Schmidt, Richard Setlow (adjunct), and biological DNA transfer mechanisms. Bacteriophage as well as Sanford R. Simon, Steven Smith, Rolf Sternglanz, F. William lower and higher eukaryotic systems, are used to illustrate aspects of Studier (adjunct) molecular genetic structure and function. (Note: this course jointly listed as HBM 503) Associate professors: Paul Bingham, Deborah Brown, Vitaly 3 credits, fall term, staff Citovsky, Neta Dean, Nancy Hollingsworth, Dale Deutsch, Robert Haltiwanger, Bernadette Holdener, Harvard Lyman, MC B 509, 510 Experimental Biochemistry An introduction to modern biochemical research techniques. The stu- Gerald Thomsen dent spends a half term in the laboratory of each of four different mem- bers of the staff selected in consultation with the course director. In Assistant professors: Jen-Chih Hsieh, Aaron Neiman, A. Wali each laboratory the student participates in some aspect of the ongoing Karzai, Hermann Schindelin research pursued by the faculty member. 2 credits each term, variable, fall and spring, faculty This department offers fundamental courses in biochemistry and cell biology to students in the health professions, as well as to undergraduates and graduates in biochemistry and biology. MC B 512 Physical Biochemistry Its graduate studies are centered on an interdisciplinary pro- Theoretical principles and experimental methods used in the study of proteins and nucleic acids, e.g., spectroscopy, magnetic resonance and gram in molecular biology, biochemistry and cell biology, and diffraction. also a graduate program in structural biology. Prerequisites: BMO 520, CHE 301 or 312. 2 credits, Dr. London Courses Refer to the Undergraduate Bulletin (Biological Sciences Sec- MC B 517 Biomembranes tion) for a complete listing of undergraduate course offerings. Examines the molecular architecture of membranes; the organization, functions, and assembly of lipids and proteins in biological mem- HB C 33 1 Introductory Biochemistry branes. An introduction to biochemistry including all aspects of metabolism and Prerequisite: Permission of instructor. the synthesis, struc t u r e, and function of DNA, RNA, and protein stres s e s 1 credit, fall term, Dr. London the medical significance of these aspects of biochemistry. 3 credits, fall modules, Dr. Schechter MC B 520 Graduate Biochemistry I Several topics in modern biochemistry are treated at an advanced HB C 53 1 Molecules, Genes and Cells level. Topics covered will include protein structure, enzyme kinetics An integrated course covering the important aspects of biochemistry, cell and mechanisms, and enzyme regulation. bi o l o g y , human and molecular genetics, and histology. Includes lectures , Prerequisite: HBC 331. small group conferences and laboratories and stresses the clinical rel e - 3 credits, fall term, Dr. Schmidt vance of the basic science material. 8 credits, fall term, Dr. Simon BMO 580 Teaching Honors Selected students whose performance in the basic required courses for the graduate program is in the top 10 percent conduct tutorials for first-year graduate students in the program and other students taking 124 graduate courses for credit. The tutors are supervised and graded by BSB 604 Student Seminars in Biochemistry program faculty of the graduate program. Successful completion of and Structural Biology this course will make the students eligible to receive an “Honors in Seminars given by graduate students on the progress of their own the- Teaching” on their transcript. sis research. Required of all students every semester in which they are 1 credit, fall and spring terms registered in the Graduate Program in Biochemistry and Structural Biology. Attendance is mandatory. Visitors are welcome. BMO 599 Research Fall and spring, 1 credit, S/U grading Original investigation undertaken under the supervision of a member of the staff. BSB 699 Dissertation Research Credit to be arranged, fall and spring terms, faculty Original investigations undertaken as part of the Ph.D. program under supervision of a research committee. BMO 601, 602 Colloquium in Molecular Biology Prerequisite: Advancement to candidacy (G5) A weekly series of talks and discussions by visiting scientists covering Fall, spring, and summer, 1-12 credits, S/U grading current research and thinking in various aspects of molecular and cel- May be repeated for credit lular biology. Required for all students every term in which they are registered in Graduate Studies in Molecular Biology and Biochemistry. BSB 800 Summer Research Attendance is mandatory. Visitors welcome. 0 credits, S/U grading 1 credit each, fall and spring terms, faculty

BMO 603, 604 Student Seminar in Molecular Biology Department of Dermatology Seminars given by graduate students on the progress of their own the- sis research. Required of all students every term in which they are reg- istered in Graduate Studies in Molecular Biology and Biochemistry. Chair: Richard A. F. Clark Attendance is mandatory. Visitors welcome. 1 credit each, fall and spring terms, faculty Professors: Richard A. F. Clark, Barry Gruber, Marcia Simon, Lome Taichman BSB 685-688 Advanced Seminars Topics to be arranged. Visitors are welcome. Associate professors: Jonathan Garlick, Richard S. Kalish, Marcia G. 1 credit each, fall and spring terms Tonnesen BSB 699 Research Original investigations undertaken as part of the PhD program under Assistant professors: Bernard Berger, Chih-Shan Jason Chen, supervision of a research committee. Paul Chu, David Counts, Scott Flugman, Azim Khan, Peter Prerequisite: Advancement to candidacy. Klein, David Kriegel, Leonard Kristal, James Krivo, Laurie Credit to be arranged, fall and spring terms, faculty Levine, Lawrence Lieblich, Ashfaq Marghoob, Steve McClain, Richard Miller, Gavin Moynihan, Antoinette Notaro, Peter BSB 509 Experimental Biochemistry O’Neill, Lawrence Pacernick, Peter Reisfield, Xiang-Dong Ren, and Structural Biology Lynn Silverstein, Robert Skrokov, Amy Steinberg, Diana Sun, An introduction to modern biochemical research techniques. The stu- Shyam Verma, Marvin Winston dent spends a half semester in the laboratory of each of four different members of the faculty. In each laboratory, the student participates in some aspect of the research being pursued by the faculty member. Adjunct Professors: Frank DeMento, Joel Gordon, Fall and spring, 1-4 credits, ABCF grading May be repeated for credit Clinical Instructor: Deborah Deierlein

BSB 510 Experimental Biochemistry The Department of Dermatology is committed to providing and Structural Biology quality education in cutaneous biology and skin disease to An introduction to modern biochemical research techniques. The stu- medical students, residents, and fellows. Emphasis is placed dent spends a half semester in the laboratory of each of four different on the integration of principles of basic pathophysiology with members of the faculty. In each laboratory, the student participates in clinical manifestations and preventive medicine, and on the some aspect of the research being pursued by the faculty member. Fall and spring, 1-4 credits, ABCF grading development of problem solving and diagnostic skills. May be repeated for credit In conjunction with the Department of Orthopedics, Depart- ment of Pathology, Department of Radiology and Department BSB 515 Computational Methods in Biochemistry of Medicine/Divisions of Allergy, Immunology and Rheuma- and Structural Biology tology, the Department of Dermatology participates in the Computational methods used in sequence searching and analysis, Connective Tissue and Skin Systems Course for second year bioinformatics, graphical analysis of proteins, and nucleic acids. medical students. The format varies from didactic lectures to Fall, 1 credit, S/U grading workshops and clinical pathologic correlations, including an opportunity for students to interact with patients. BSB 599 Research Original investigation undertaken with the supervision of a faculty A one-month clinical elective is offered during the fourth member. year, which provides exposure to the diagnostic and manage- Fall and spring, 1 – 12 credits, S/U grading ment of cutaneous disorders in both the ambulatory and inpa- May be repeated for credit tient setting at University Medical Center, Stony Brook Tech- nology Park and the Northport Veterans Af fairs Medical Center. BSB 603 Student Seminars in Biochemistry Dermatology has been integrated into the surgical sub-spe- and Structural Biology cialty selective for fourth year medical students. Every two Seminars given by graduate students on the progress of their own the- weeks, two students rotate through Dermatology shared with sis research. Required of all students every semester in which they are plastic surgery. Students are scheduled in teaching clinics in registered in the Graduate Program in Biochemistry and Structural Biology. Attendance is mandatory. Visitors are welcome. the ambulatory facility and the Northport Veterans Affairs Fall and spring, 1 credit, S/U grading Medical Center Dermatology clinical sessions. Students with a specific interest in Dermatologic Surgery will be scheduledac- cordingly.

125 A three-month research elective provides in-depth exposure dents include advanced life support training at the end of the to academic dermatology and the application of laboratory sci- second year, a third-year clinical elective, fourth-year sub- ence to clinical problems through participation in a laboratory internship and clinical elective, and a four-week introduction or clinical research project. to emergency medicine (classroom and procedure labs) in the A three-year dermatology residency training program pro- fourth year. A three-year residency in emergency medicine vides structured education in basic cutaneous biology and began in July 1990. Residents from other services are offered pathophysiology and extensive exposure to patients with skin specialized instruction in clinical topics and procedures during disorders. The training experience comprises all aspects of rotations in emergency medicine. ambulatory and inpatient dermatology, including dermatolog- ic surgery, dermatopathology, and phototherapy. Opportunity is provided for involvement in basic science and/or clinical Department of Family Medicine skin research. The Department of Dermatology is actively involved in continuing medical education for staff, community Chair: Jeffrey S. Trilling practitioners and healthcare professionals through CME accredited Grand Rounds, conferences, seminars and through Associate professors: Lisa Baker, Stanley E. Blyskal, Robert S. participation in local dermatologic societies. Bobrow, Richard Bonanno, Clive Caplan, Frederick Caston, Marius Chagoury, Alan Cooper, Christine Delgaizo, Susan Donleavy-Johnston, Edward L. Feldman, Kenneth Feldman, Department of Emergency Medicine Jerry Reed Frank, Genine Francis, John Franco, Francis Glea- son, David Goldman, Gerald Green (Emeritus), Maury Green- Chair: Mark C. Henry berg, Susan Groh, Raja Jaber, Arnold Jaffe, Leslie Johnson, Scott D. Kirsch, Marc Lewandoski, Joseph Loiodice, Mian Vice chair: Peter Viccellio Long, Antoun Mitromaras, Christopher Ng, Lynn-Marie Nitti, Andrea Nomberg, Russell W. Porter, Ronald Roth, Samuel Professors: Mark C. Henry, Howard C. Mofenson, Frederick M. Sandowski, Jill Sisselman, Johnny Slade, Jay Slotkin, Samuel Schiavone, Adam Singer, Peter Viccellio Smith, Farzad Tabibzadeh, Waleska Tulier-Pastewski, Richard Vickers, Michelle Young Associate professors: Thomas R. Caraccio, Lester Kallus, Subir R. Maitra, Henry Thode Assistant professors: Sergio Abramoff, Marsha Alger, T. David Annear, Carlo Annese, Jill Baron, Alfred Belding, William Assistant professors: Gerald M. Brody, Christopher Carleo, Stu- Bennett, Joseph Calandrino, Cynthia Carlson, Rosalie Castillo, art Chale, David Cohen, David S. Cooling, Kerry Cronin, Michael J. Confusione, Josephine Connolly-Schoonen, Richard Dickinson, Robert Ehlers, Daniel R. Ferrara, Thomas Francine Cormier, Susan DeBevoise, James Dragone, George Fischer, Laura Fochtmann, Gregory P. Garra, Clark S. Homan, F. Dunn, Raymond Ebarb, Michael M. Fishkin, Melanie Frank, Scott Johnson, Lester Kallus, Melina LoGuidice-Khwaja, Cori Rollin Gallagher, John Gil, Peter E. Goldstein, Louis Green- Ann McKean, Joan L. McInerney, Maria Mortimer, Erika New- blatt, Anthony Guida, Hassan Hito, Mark Jagust, Sabrina ton, Theodore Pachy, Edward R. Stapleton, Ioanis Siderias, Vic- Johnson, Gerard Kelly, Daniele Kenny, Donald Kiaer, Ahtaran tor Tarsia, Andrew Wackett Khan, Colin P. Kopes-Kerr, Carl Korpi, Michael Ladinsky, Richard S. Litman, Nicholas Livrieri, Frank LoBacz, Kumar Instructors: Rodrigo T. Del Rosario, William Flader, Eric Niegel- Mandal, Ashfaq Marghoob, Donna Meltzer, Richard Murdoc- berg, David G. Schwartz, John G. Veliath co, Jeanine Morelli, Alan J. Nelson, Robert S. Nissan, Anthony Pesce, Annette Racaniello, Michael Randall, Lesley Rechter, Clinical instructors: Adam Church Anne Robbins, William Robbins, Deborah Schaefer, William H. Sher, Eric Shoenfeld, Meryl Solomon, Robert E. Sterling, The department of emergency medicine provides clinical ser- Gwendolyn Stretch, Howard Sussman, Paul Tchao, Joseph vices for University Hospital, a residency program in emer- Venezia, Louis T. Verardo, Joseph C. White, Catherine Wight- gency medicine, educational programs for the School of Medi- man, William Wright, Edward Yambo, Ephraim K. Zackson cine and the community at large, and opportunities in basic science, clinical, and health policy research. Instructors: Sandra Leonard The faculty provides 24-hour staffing in the University Medical Center Emergency Department and supervision and The Department of Family Medicine emphasizes teaching, medical direction for the Suffolk County EMS Advanced Life clinical practice and research in the practice of continuing, Support System. comprehensive and family-oriented care to patients. The many The department, in cooperation with the School of Health educational missions of Family Medicine include management Technology and Management, initiated the first paramedic of common illnesses, health promotion and disease prevention, training program on Long Island in 1991. family practice obstetrics, behavioral medicine and accessibili- Research opportunities are available for faculty, residents, ty to care. and students in the medical school and university. The depart- The department’s role in the medical school curriculum ment of emergency medicine has faculty members with exper- includes directorship of Introduction to Clinical Medicine tise in research design and statistics to assist with research pro- (years 1 and 2), Introduction to Human Behavior (year 1), a jects in basic science, clinical emergency medicine, and health required Clerkship in Primary Care (year 3), and a subintern- policy. The department has continuing grants for response- ship and elective (year 4). An elective Summer Preceptorship in wide trauma quality improvements and injury prevention. Family Medicine (year 1) is available with limited enrollment. Grand Rounds, weekly core curriculum, and case review con- In postgraduate education, the Family Medicine Residency ferences are available to practitioners outside the university as Program provides 21 residents with comprehensive training in continuing medical education offerings. the discipline. It also directs a consortium of residency pro- Education programs in emergency medicine for medical stu- grams at Southside Hospital, South Nassau Community Hos-

126 pital, and Community Hospital at Glen Cove. Katz, Robert J. Kramer, Walter Noah Kromholz, Gerond Lake- The Department of Family Medicine has demonstrated a B a k a a r, Erich Mackow, George Mallis, Augustus Mantia, commitment to the community through its outreach programs Edward Mack, Robert Marcus, John Maresca, Robert J. Mich- and primary care initiatives. These programs are coupled with tom, Sidonie A. Morrison, Sriram Naidu, Howard Novotny, teaching and clinical responsibilities in the ambulatory and Thomas O’Riordan, Roman Pachulski, Sanford Pariser, inpatient services of University Medical Center as well as at Enrique Pastoriza-Munoz, Crescens Pellecchia, Agit Penja, community based sites throughout Suffolk County. The Melvin Praissman, Florence Prigent, Earnst Raeder, Linga Raju, Department of Family Medicine coordinates and delivers con- Suhail Raoof, Martin S. Roginsky, Bernard Rosof, Frances San- tinuing medical education programs to the medical communi- tiago-Schwartz, Richard Schwarz, Robert Shaw, Joel E. Sher- ty and conducts healthcare and service research. lock, Tsiporah Shore, Michael Silverberg, Susan Simandl, E. Marvin Sokol, Harry Staszewski, Sorel Sulimovici, Herbert Susskind, Charles Steinman, Marcia Tonnesen, , David Volk- Department of Medicine man, Nand Wadhwa, Shing-Shing Yeh, Stephen Zeldis, Michael Zema, Myron Zitt. Chair: Benjamin J. Luft Assistant professors: Shadab Ahmed, Zvi Alpern, Michael Vice chair, Clinical and Hospital Affairs: Leonard Arbeit Ammazzalorso, Joseph Anderson, Eugene M. Aronow, Jeffrey R. Ashkin, Evangelia Augoustiniatos, Louis Auvento, Quaiser Vice chair, Academic Affairs: Roy Steigbigel Bakht, Wendy Balopole, Leah Balsam, Richard A. Balter, Bhaskar Banerjee, Daniel Baram, John Bateman, Najma Director of Inpatient Programs: Richard Barnett Begum, Donald J. Behr, Elise Belilos, Ronald Bennett, Evan Berger, Jeffery Berger, Richard E. Berman, David Bernstein, Director of Education: David Tompkins Mark Bernstein, Ronald S. Bertcher, Leonard M. Birch, John Birk, Charles Bleecher, Niranjan Bookanakere, Akron Boutros, Medical Director, LI State Veterans Home: Frank Cervo Edward Bosler, Akram Boutros, Pierre Brutus, Bernard Bren- nan, B. Lawrence Brennan, Edward Brown, John Bruno, Peter Affiliation chairs: Steven Walerstein, Nassau University Med- Bruno, Patricia Burns, Jian Cao, Linda Carmosino, Rocco ical Center; Michael Niederman, Winthrop-University Hospi- Caruso, Hugh Cassiere, Thomas C. Catalano, Eugenio Cer- tal; Mark Graber, Veterans Affairs Medical Center, Northport sosimo, Joseph Cervia, Frank A. Cervo, Michael Cesa, Stuart Chale, Elizabeth Chau, Edward Cheng, Howard Citrin, Diane Professors: John F. Aloia, Reese Aslop, Wadie Bahou, William Clausen, Gail Cohan, Sandra Cohen, William J. Cohn, Benjamin, Michael Berelowitz, Jesse M. Berkowitz, Victor P. Stephen Cokinos, Michael J. Connolly, Arnold Conrad, David Bond, Douglas Brand, Robert Burakoff. Harold Carlson, Chris- Cooling, Donald Coppock, George Coritsidis, Lisa D. Cupit, tos Carvounis, Wen-Tien Chen, Richard Clark, Ira Cohen, Peter Noshir DaCosta, Ralph Delaratta, Joseph Dell’Orfano, Ralph F. Cohn, Stanton H. Cohn, Barry Coller (Adjunct), John Coule- Della Ratta, Michael R. Delman, Frank J. DeMento, Oscar A. han, Eugene P. Cronkite, Burke Cunha, Raymond Dattwyler, Devera, Kathleen Dickman, Mark DiBenedetto, Joan Dobbs, Norman Edelman, Alan M. Fein, Donald A. Feinfeld, Susan Philip Domenico, Susan Donelan, Glen Egelman, Thomas J. Forlenza, Harry W. Fritts, Jr., Edmund D. Pellegrino Professor Ekkers, David Farr, Norbert Felber, Getachew Feleke, Alan of Medicine, (Emeritus), Pierce Gardner, Marie Gelato, Berhane Fetterman, Albert F. Finn Jr., Nick Fitterman, Bradley Flans- Ghebrehiwet, Michael Goligorsky, Peter Gorevic, John Gottdi- baum, Philip R. Fleishman, Cornelius J. Foley, Kenneth ener, Mark Graber, Robert Greenwald (Adjunct), Arthur P. Freese, Phyllis D. Fried, Steven P. Friedling, Gary Friedman, Grollman, Barry Gruber, Mae Hultin, Jolyon Jesty Alan Kaell, Stephen W. Furst, Anthony Gambino, Liziamma George, Jody Faroque Khan, George J. Kaloyanides, John Kovach, William Greenfield, Gino L. Giorgini, Jr., Avram Gold, Richard L. Lawson, Joseph Letteri, Martin R. Liebowitz, Benjamin J. Luft, Golden, Steven Golub, Mark A. Goodman, David Goodrich, Stefan Madajewicz, John Maesaka, Thomas Manis, Amitabha Margaret M. Grant, Michael N. Greenblatt, Rocco Grella, Sey- Mazumder, Edward Meilman, Leonard E. Meiselas (Emeritus), mour Greenwald, Frank Gress, Maritz Groth, Edgar Grun- Morton Meyers, Larry Nathanson, Michael Niederman, waldt, Marwan Habeeb, Carylann Hadjyane, Nabil Hagag, Edward Nord, Robert Olson (Emeritus), David Parkinson, Max I. Hamburger, Aaron Harrison, Janet Hearing, Elaine Edmund D. Pellegrino, Ira Rezak, John R. Sachs, Sami Said, Hearney, Donna Heinemann, Eugene Heller, Alexander Hin- Lawrence Shapiro, Walton Shreeve, Gerald Smaldone, Roy denburg, Herbert Hirsch, Dennis Hoffman, Melvin Holden, Steigbigel, Richard Steingart, Kingsley Stevens (Emeritus), Ingolf Holm-Andersen, Rosalind Hopmeier, Richard William Van Nostrand, James Veh, Michael Viola, Steven Horowitz, John Hui, Stanley Hyman, Chul Soo Hyun, Vitkun, Stephen Vlay, Stephen Weinstein, James Yeh, David W. Bassiema Ibrahim, Jonathan Ilowite, Louis J. Imbriano, Scott Westring, Mohammad Zarrabi, Stanley Zucker Ingber, John Ippolito, Gary R. Joachim, Regina Jablonski, Alan Jacobson, Diane Johnson, Robert Johnson, Sara Johnson, Associate professors: Leonard Arbeit, Syed Asad, Michael Balkin, Richard S. Joseph, Hosam Kamel, Ali Karakurum, Jeffrey Kas- Richard Barnett, Najma Begum Rachel Bergeson, Steven Car- saz, Inderjit Katyal, Darren S. Kaufman, Robert Kazenoff, Juf- sons, Joseph Chernilas, Todd Cohen, Donald Coppock, Mark J. frey Kazzaz, Eugene M. Kern, Leonard Kertzner, Hossein Corapi, George Coritsidis, Alfred M. Derrow, John Dervan, Keyvan, Jung-Yong Kim, Diane L. Klein-Ritter, Natalie Klein, Troy Dixon, Michael Dubin, Peter Ellis, Gerald Ente, Edmund Robert Klein, Myron Kleiner, Kavita Kongora, Giridhar Korli- F. Fallon, Steven Feffer, Suzanne Fields, John Fiore, Steven papa, Edward Kowalski, Walter N. Kromholz, Lawrence S. Fishbane, Hussain Foda, Luz Fonacier, Susan Forlenza, Israel Kryle, Gamesh Kumar, Harvey Kuschner, James P.G. Kwee, Freeman, Marianne Frieri, Howard Frucht, Jack Fuhrer, Dennis Reuben Leass, Alice Lee, Tai-Ping Lee, Lloyd Lense, Harvey Galanakis, Aaron Glatt, David Goddard, Edward Goffried, Irv- L. Lerner, Younghee Limb, David Lin, Zeena Lobo, Maria ing Gomolin, Howard Gottfried, William H. Greene, Louis London, Paul A. Lusman, David T. Lyon, Gregory Macina, Heller, Adam Hurewitz, Joanne Holland, Junichi Iwai, Victor Lucy Macina, Edward Mack, Vincent V. Madonia, Robert Jiminez, Ernesto Jonas, Anoop Kapoor, Ashok Karnik, Jordan Malacoff, Harish Malhotra, Lucy Malisan, Abeera Mansur,

127 Philip A. Mantia, Rajkumar Mariwalla, Dwight W. Martin, Sudhar Gurman, Isaak Halegoua, Lisa Hammer, Shirley Kevin Marzo, Christopher Matkovic, Evangelos Mavrogeor- Hanna, Maureen Haralabatos, Alan I. Harris, Laura Harring- gis, Daniel Mayer, Frank Mazzola, Joan McInerney, William ton, Edmund Hayes, Marc Hazan, Ronald M. Henry, Patricia McKean, Alan Mensch, Marco Michelson, Dennis Mihalatos, Hentschel, Kevin Ho, Carrie Hofer, Eric Hoffman, Bru c e Mageda Mikhail, Tanveer Mir, Felix A. Monaco, Howard D. Horowitz, David M. Horowitz, Mohammed S. Hossain, Zita K. Morgenbesser, Robert Mormando, Tahin Mufti, Dennis Hsia, John Hsueh, Patricia Hubbard, Kenneth S. Hurst, Ashfar Mynarcik, Ian Newmark, Bookanakere Niranjan, Patricia Hussain, Hamid Hussain, Jeanie Huysman, Paul M. Hyman, Nolan, Laurence I. Novick, Edwin Oberstein, Daniel J. Diala Jaber, Rajer Jaubar, Daniel Jeran, Shashi B. Jhamb, Robert O’Hearn, Olukayode Ojutiku, John Oppenheimer, Abuzafar C. Johnson, Sudha Kamath, Wei Kao, Hacik Karabedian, Nago- Osman, Stanley Ostrow, Tobia Palma, Lucy Palmer, Asit rao Karhade, Frank Karpowicz, Shyamala Karuvannur, Danny Panja, Frederick Paolo, Leo G. Parmer, Rose Marie Pas- Kass, Gail Kellner, Rita Kelly, Howard Keschner, Shahriar mantier, Shenyi Peng, William Percy, Susan Platkin, Lester N. Khalili, Mina Khorshidi, Junkop Kim, Arthur Klein, David Ploss, Martin D. Podgainy, Bonnie Pollack, Anand Prachi, Klein, Jasjit Kochar, Giridhar Korlipara, Harry Kousourov, Vincent W. Prestyly, Ronald A. Primis, Soma Pulipati, Robert T h e resa Kramer, Norbert Kre m e r, Jonathan Krohn, David J. Rabinowitz, Louis Ragolia, Frank Raio, Frederick Reindl, Kugler, Karen Ann Lacey, Corradino Lalli, Susan Lane, Edward John Reitano, Thomas Ribaudo, Albert Riccio, William Rifkin, F. Lanigan, John Lanzone, Jason Lazar, Steven Lederman, Seymour D. Ritter, Mohammed Rizvan, John Rodrigues, Grace Lee, Susan Lee, Renee Lefland, Agim Leka, Lloyd Lense, Rosario Romano, Victor Romanov, Michael Rosenban, David Je ff r ey Leonardis, Heather Lewis, William LiPera, Joanne S. Rosenthal, Stuart W. Rosner, Peter Rumore, Sharona Sachs, Lopez, Mark Davis-Lorton, Arthur Lowey, Alan Lucks, Lynne Edward Samuel, Harold S. Sandhaus, Arnold E. Sands, Maher, Brian Margolis, Michael Matilsky, Thomas McBrearty, Mitchell Saunders, Frances Santiago-Schwarz, Ira H. Scheiner- Maryanne McCoy, Phyllis Migdal, Jacqueline Milch, Nancy man, Joseph Schepis, Frederick Schiavone, Jeffrey Schneider, Miller, Marlena Mirca, Anne Marie Mirski, Katherine Mitchell, Mrudula Shah, Michael Shepley, Nancy Lee Shinowara, Her- Angela Mitrani-Schwartz, Ralph Modica, Arun Mohile, Miguel bert I. Silverberg, Susan Simandl, Jay Slotkin, Richard Smith, Molina, Steve Montana, Patricia Montes, Harvey Mossman, Philip Spadafora, Jacob Sokol, Alan Spielberg, Subramaniam Hachiro Nakamura, Sheila Natbony, Arain M. Nawaz, Mary Srinivasan, Thomas Stavola, Michelle Steffers, Leonard Stein, Nekola, David Nevins, Maria Noya, Dennis S. O’Brien, Kevin Alan Steinberg, Lisa Strano-Paul, Jaishree Subramani, Heswck Olson, Linda Olson-Vlay, Linda Ord i n g - B a u e r, Hadassah Suh, Krishnamurthy Suresh, Anthony Szema, Yoshiko Orenstein, John A. Ostuni, Lawrence Pacernick, Bruce Paul, Takeshita, Dennis Tansiongco, Shirley Tansiongco, Wen-Wei Bernadette Pavlis, Rohan Perera, Bala Hari Pillai, April Plank, Tchou, Hebbalmath Thippeswamy, Robin Thompson, Louis Josephine Posillico, Marie Pottanat, Rajendra Prasad, Sami H. Tiger, Allan H. Toffler, Steven Tollin, Adrian Torres, Joseph Qazi, Alfred Raciti, Ramona A. Rajapakse, Louise Raminfard, Tripedi, David Tompkins, Anil Vaidian, Ashok N. Vaswani, Michael Rechheimer, Indira M. Reddy, Thomas Reisman, John Janice Verley, Peter Viccellio, Stanley M. Vickers, Stephen R i c c i a rdelli, Michael Richheimer, Gary Rosenblum, Glen Vitkun, Kathleen Rene-Walsh, Laurie Ward, Rosalind Wat- Rosett, William Ross, Paul Rossano, Victoria Rourke, Dennis man, Jed Weinberg, Michael Weinstein, Edward Weissman, Russo, Richard Sabinsky, David Sacknoff, Francis J. Safina, William Wertheim, Jonathan Whittaker, William Wortheim, Ellen McCarty-Santora, Steven Satnick, Majeed Ahmed Say- Evelyn Wolf, Ching-Hui Wu, Li-Cheng Xu, Owen Yen, Melvin eed, Judith Scheppler, Schmelzer, Arnold W. Schreiber, Paul W. Young, Qamar M. Zaman, Athena Zias, William Zirker, Schulman, James Schmertzides, Marisa Shapiro, Sa Njiv Shar- Jerome Zisfein, Sheldon Zuckerman ma, Paul Shulman, Gary Schwartz, John J. Scomillio, Anuja Shah, Shahin Shaikh, Sheldon C. Simon, Stephan Simons, Instructors: Mark Adler, Lynn Adams, Qazi Afzal, Poonam Stephen Sisselman, Prema Siva, Kenneth F. Solinsky, Mark Alaigh, Seymour Alter, Chandri Anand, Charles Annunziato, Solomon, Anthony Spadaro, Gregory Spisak, Julie Stack-Fried, Vincent Avila, Bagdig Baghdassarian, Robert Baranowsky, Barbara Starke, Theresa Stavola, Philip Stein, Mary Straw, Eliz- Nicholas Barberi, Peter R. Barra, Michele Becker-Hamou, Esen- abeth Strum, Michael Sussman, Shirley Sussman, Jean Swartz, bike Bek, Norman Bennett, Nicholas Berbari, Marion J. Kathleen Taibi, William Taibi, Mandar Tak, Mark Tan, Emily Bergman, Elena R. Berkowitz, Paul Bermanski, Gary Bernstein, Tanel, Mandar Tank, Marilyn Temkin, Babu Thallur, Michael E. Stephen Bernstein, Raman Bhasin, Harcharan Bhati, Vikas Theodorakis, Jill Thorton, Djin Y. Tjioe, Mary Varughese, Vad- Bhushan, Colleen Bianco, Stuart Bitterman, Mark Bore k , digiri Venkatesh, Andrew Weber, Marc A. Weinberg, Tchou Robert Boswell, Howard Brand, Paul K. Brodsky, Samuel Wen-Wie, Craig Wexler, Nancy Wichtendahl, Barbara Wilk, Brody, Patricia Burns, Douglas Byrnes, Michele Caccavani, Ranvic Yadav, Patricia Yankus, Daniel Yellon, Michelle Young, Anthony Calio, Michael Camardi, Scott Capustin, Michael Shug-Hong Young, Athena Zias-DiLena, Ronald Zielinski, Carl, Maria Carney, Sandeep Chandra, Joseph Chandrankun- Demetrius Zodiatis, Rana Zoeb nel, Aileen Chang, Opkar Chawla, Judith A. Chown, Howard L. Cohen, Christine Colacino, Eugene Coman, Susan Conaty, The Department of Medicine encompasses eleven divisions: Marilyn Connor, Margaret Costello, Stephen Cusumano, Diane Allergy & Clinical Immunology, Cardiology, Endocrinology, Cymerman, Robin DaCosta, Denise D’Ambrosia, Vijay K. Das, Gastroenterology, General Internal Medicine and Geriatrics, Colleen DeFalco, Mark DiBenedetto, Robert DiNapoli, Cindy Hematology, Infectious Diseases, Nephrology, Medical Oncol- DiPalo, Patricia Dobbins, Kathleen Donnelly, Elliott Dreznick, ogy/ Neoplastic Diseases, Pulmonary and Critical Care Medi- Yasser-El-Hennawy, Davis Franco, Thomas Fischer, Kenneth I. cine, and Rheumatology at Stony Brook as well as its clinical Fishberger, Theodore Flamm, Monica Flanagan, John Folan, affiliates listed above. The combined faculties of these institu- Nancy Foley, Michael Fried, Christine Furth, Franco Gallo, tions are charged with the responsibility for the following: Jyoti Ganguly, Karen Garland, Michael Garrison, Brian Geller, 1) running and teaching the Introduction to Clinical Carmel V. Genovese, Robert C. Giacobbe, Tracy Gillan, Barry Medicine program Gimbel, Morton Glaser, Dmitri Gnatenko, Richard Gold, Ilene 2) planning and teaching the curriculum of Systems; Goldstein, Shirley Goodman, Perry Gould, Meeta Govindara- 3) directing the Clerkship and Sub-Internship in jan, Marie Gray, Ronald Greenberg, Theresa Grimes, Robert Medicine Grossman, Sudheer Gurram, Urbanp Guarin, Patricia Guercio, 4) developing curriculum and supervising electives in the

128 medical subspecialties tionships with the College of Arts and Sciences, other depart- 5) training 104 house officers and 60 fellows ments in the School of Medicine, the Cold Spring Harbor Lab- 6) providing Continuing Education in Medicine. oratory, and the Brookhaven National Laboratory. These efforts are coordinated by an Executive Committee Courses composed of faculty from Stony Brook and all of the clinical affiliates. HB M 32 0 General Microbiology The Department of Medicine education program is Astudy of the molecular struc t u r e, functional anatomy, growth, genet- designed to provide medical students, residents and fellows ics, and pathogenic mechanisms of microbial agents with an emphasis with a solid foundation in general internal medicine and its on bacteria and viruses. Non-specific and specific host defenses and the co n t r ol of microo r ganisms will also be covered. Satisfies the microb i o l - subspecialties, including quality patient care and research. ogy req u i r ements for admission to most allied health, nursing, optom- This goal is exemplified in the design of the medical clerkship. et r y , and veterinary medicine professional schools. Under the tutelage of full-time faculty and community precep- Pre re q u i s i t e s : BIO 202; CHE 112 or 132 tors, students learn the arts, skills, and modes of reasoning in 3 credits, spring term, Dr. G. Burton making diagnoses and managing patients. In addition, stu- dents become a part of the medical staff by delivering patient HB M 32 1 General Microbiology Laboratory care. These educational activities are supplemented by confer- Complementing the lecture material of HBM 320, this optional labora- ences, a comprehensive lecture series of topics identified as a tory covers basic and applied microbiological methods. Students are target “Core Curriculum,” the Chairman’s lecture series, small in t r oduced to methods for isolating pure cultures, microscopy and staining, quantitation of bacteria and determination of sensitivity to group sessions with the Program Director, and multi-depart- an t i m i c r obial agents. This laboratory is limited to pre- v e t e r i n a r y , and mental clinical pathology conferences. The study of the patient pr e-health professional students. as the keystone to learning medicine is stressed throughout the Co re q u i s i t e : HBM 320. inpatient and ambulatory experience. 1 credit, spring term, Staff The Post Graduate program offers training in research. Postdoctoral traineeships are available in both applied and basic research for senior house officers planning careers in aca- HB M 393, 394 Special Topics from the Microbiology Literature demic medicine. Senior students and residents may take elec- Di r ected readings in molecular genetics and microbiology with period- tives in general medicine and the medical subspecialties. ic conferences, reports, and examinations arranged with the instruc t o r s in the Department, culminating in a final paper reviewing the literature. In keeping with the goals of our education program, con- Pre re q u i s i t e : Permission of instruc t o r . tinuing education is provided at various hospitals through reg- 1-2 credits per term, fall and spring terms, staff ularly scheduled rounds and conferences. These activities, aimed at not only the members of the medical staff but for all HB M 398, 399 Research Project in Microbiology healthcare professionals, emphasize the importance of inter- An independent res e a r ch project under faculty supervision, with disciplinary approaches in analyzing problems, whether at the emphasis on the principles of experimental design, data collection, bedside or in the laboratory. evaluation of findings and reporting of results. Project report req u i re d . May be rep e a t e d . Pre re q u i s i t e s : Laboratory experience and permission of the supervising Department of Molecular Genetics and in s t ru c t o r . Microbiology 2-4 credits per term, fall and spring terms, staff

Chair: Daphna Bar-Sagi HB M 50 3 Molecular Genetics In t r oduces the classical work and current developments in lower and Professors: Carl W. Anderson (adjunct), Dafna Bar-Sagi, William higher genetic systems. Covers gene stru c t u re and regulation in pr okaryotic and eukaryotic organisms, mutational analysis and map- R. Bauer, Jorge Benach, James B. Bliska, Carol A. Carter, ping, transposable elements, and biological DNAtransfer mechanisms. Nicholas Delihas, John J. Dunn (adjunct), Paul Fre i m u t h Bacteriophage and lower and higher eukaryotic systems are used to (adjunct), Michael J. Hayman, Patrick Hearing, Winship Herr illustrate aspects of molecular genetic struc t u r e and function. Cross list- (adjunct), Eugene R. Katz, Wayne C. Koff (adjunct), Kenneth B. ed with BM0503. Marcu, Jane K. Setlow (adjunct), Roy Steigbigel, Bruce W. Still- Pre re q u i s i t e : Permission of instruc t o r . man (adjunct), Eckard Wimmer 3 credits, fall term, Drs. Futcher and Sternglanz

Associate professors: A. Bruce Futcher, Christine HB M 509, 510 Experimental Microbiology Ginocchio (adjunct) James B. Konopka, Janet Leatherwood, In t r oduces modern microbiological res e a r ch. Students rotate throu g h two professors’ laboratories spending approximately one-half term in each. Laboratory selection made in consultation with the student’s Assistant professors: Janet C. Hearing, Huilin Li (adjunct), advisory committee. By taking part in ongoing projects the student will Aniko Paul, David Thanassi learn experimental proc e d u r es and techniques and become acquainted with res e a r ch opportunities in the department. Research assistant professors: Sangeet Honey, mena Ostapchuk Pre re q u i s i t e s : Matriculation in a graduate program and permission of the pr ogram director and the lab direc t o r . Instructors: PhiloGeorge Burton Variable credits, 1-8 credits per term, fall and spring terms, staff

The department provides instruction in the biology of microor- HB M 51 1 Introduction to Biophysical Chemistry ganisms and microbe-host relationships to students in all of the In t r oduces the chemical principles and techniques needed for the study of biological macromolecules. Topics to be covered include solution health professions. It also offers undergraduate and graduate ch e m i s t r y , chemical thermodynamic, binding and dissociation equilib- courses that are needed for majors in the health-related profes- rium, denaturation phenomena, spectros c o p y , and hydrod y n a m i c s . sions as well as the basic sciences. This course is intended to prep a r e non-chemistry majors for more Department and interdisciplinary programs in graduate advanced work in biophysics. Cross-listed with HBY511 . study and research are directed towards viral and cellular Pre re q u i s i t e : Permission of instruc t o r . oncology as well as the molecular mechanisms of bacterial and 3 credits, fall term, even years viral pathogenesis. The department has particularly close rela-

129 HB M 52 2 Biology of Cancer students in the health professions as well as to undergr a d u a t e s Short course emphasizes cancer as a disease of man. Ad d r esses human and graduates in biology. Its graduate studies are centered cancer as seen by the clinician and as basic res e a r ch relates to human ar ound the program in neurob i o l o g y . disease. Provides a link between courses in cell and molecular biology and the application of this basic information to tumor management. 1 credit, spring term, even years, Drs. Hayman and Hagag Co u r s e s HB M 53 1 Medical Microbiology Pr esents information derived from molecular genetics and cellular biol- BIO 203 Cellular and Organ Physiology ogy of microo r ganisms to provide a foundation for understanding basic The fundamentals of cell and organ physiology in mammalian and non- mechanisms underlying pathogenicity of viruses, bacteria, fungi and mammalian organisms. The struc t u r e and function of cell membranes pr otozoa. Laboratory experiments demonstrate techniques to identify and the physiology of cell to cell signaling, cellular respiration, and and quantify bacteria. homeostatis of organs and organisms are examined with an emphasis 1-4 credits, fall module, Dr. Benach on the comparative physiology of vertebrates and invertebrates. Three hours of lecture and one three-hour laboratory per week. HB M 59 9 Graduate Research Pre re q u i s i t e : Bio 150 Original investigations under faculty supervision. Pr e-or Co-requisite: CHE 111 or 121 or 131 or 141; MAT 125 or higher Pre re q u i s i t e : Permission of instruc t o r . (or the discontinued MAT 124) Variable credits, 1-9 per term, fall and spring terms, staff 4 credits

HB M 640 Molecular Mechanisms of Microbial BI O 20 8 Cell, Brain, Mind Pa t h o g e n e s i s The human brain allows movement, thought and emotion. As an elec- This course covers the principles and molecular mechanisms of patho- tr ochemical computer, it is the target of diseases, drugs and psycholog- genesis of a selected group of the best understood viral and bacterial ical disturbances. Explores these topics through a knowledge of basic pathogens. Amajor focus of the course relates to pathogen modification cell neurobiology and considers the implications of brain science for of host extracellular and intracellular signalling events, as well as human behavior in society. For students not majoring in the biological pathogen-host interactions pertaining to the innate, humoral and cellu- sciences. A co r e course satisfying natural sciences category B. lar responses to infection. The material is presented by invited lecturer s Pre r equisites: High school chemistry or CHE 111; BIO 101 or 150. who are leaders in their fields. This course is directed to graduate stu- 3 credits, fall term, faculty dents, post-doctorate and medical fellows, and advanced medical stu- dents who are contemplating careers in infectious disease res e a rc h . BI O 21 0 Human Physiology Pre re q u i s i t e : HBM/BMO 503 and BMO 520 The basic principles of human physiology. The subject matter covered 3 credits, fall term, Drs. Hearing and Bliska includes presentations on the anatomical organization and physiologi- cal functions of central and peripheral nervous systems; skeletal an d HB M 69 0 Microbiology Seminar smooth muscles; cardi o v a s c u l a r , respiratory, and renal systems; and A weekly meeting for discussion of current res e a r ch in department. endocrine and rep r oductive systems. The course is designed for pre- En r olled students present seminars each week throughout the term. nursing students. May not be taken for credit by biology majors. Three Pre re q u i s i t e : Permission of instruc t o r . hours of lecture, one hour recitation, and one three-hour laboratory per 1 credit each term, repetitive, fall and spring terms, staff week. Not for credit in addition to BIO 203. Pre re q u i s i t e : BIO 150, Advisory prer equisite: A N P3 0 0 HB M 69 1 Readings in Microbiology Literature 5 credits Readings in microbiology literature covering areas of molecular biolo- gy and genetics. BI O 307 Computer Modeling of Biological Systems Pre r equisite: Permission of instruc t o r . Tools for visualizing and modeling biological systems. Tools include 1 credit, fall term, staff graphics programs, spread sheets, software for modeling dynamical systems and instruments for real-time data collection and data analysis HB M 69 9 Thesis Research in Microbiology including image acquisition and analysis. Study of models of popula- For the student who has been advanced to candidacy. Original res e a rc h tion growth, ecology, and neuron and other biological systems. under the supervision of the thesis adviser and advisory committee. Pre r equisites: BIO 201 or 202 or 203; CHE 132; MAT 125 or higher Pre r equisite: Permission of thesis adviser. 3 credits, spring term, faculty Variable credits, 1-9 credits per term, fall and spring terms, staff BI O 31 7 Principles of Cellular Signaling HB M 80 0 Full-time Summer Research Basic principles of cellular signaling and maintenance of cellular and Full-time laboratory res e a r ch projects supervised by staff members. or ganismic homeostasis through intra and intercellular signaling mech- Pre r equisites: Permission of instructor and full-time graduate student anisms. Emphasizes relationships between nuclear events and ongoing st a t u s . pr ocesses of the cell. The roles of membrane receptors and second-mes- 0 credit, summer term, staff senger pathways in mediating such diverse events as bacterial chemo- taxis, protozoan locomotion, and secretion are discussed. Pre re q u i s i t e s : BIO 202 or 203 Department of Neurob i o l o g y and Behavi o r 3 credits, fall term, faculty BI O 32 8 Mammalian Physiology Ch a i r : Lorne M. Mendell The basic principles of human physiology. Includes circulation, res p i r a - tion, nutrition, excretion (and their control by the nervous and Pr ofessors: Paul R. Adams, Paul Brehm, John B.Cabot, L. Craig endocrine systems), and sensation and coordination. May not be taken Ev i n g e r , Joseph Fetcho, Simon Halegoua, Joel M. Levine, Gail for credit in addition to HBY 35 0 . Mandel, Gary G. Matthews, Lorne M. Mendell, S. Murray Sher- Pre re q u i s i t e s : BIO 203 man, Stephen Yaz u l l a 3 credits, fall term, faculty BI O 33 4 Principles of Neurobiology Associate prof e s s o r s : William F. Collins III, James Gnadt, David Discusses the ionic basis of nerve potentials, the physiology of synaps- McKinnon, Mary Kritzer, Maurice Kernan es, sense organs and effectors, and the integrative action of the nervous Assistant prof e s s o r s : Howard Sirotkin, Lonnie Wollmuth sy s t e m . Pre re q u i s i t e s : BIO 203; CHE 131 or 141 This department offers fundamental courses in neurobiology to 3 credits, fall term, faculty

130 BI O 33 5 Animal Physiology Laboratory BN B 56 1 Neurobiological Basis of Vis i o n Laboratory exercises illustrate principles learned in BIO 328. Top i c s This course introduces students to the basic principals of neurobiology include muscles and hormones, physiological activities of nerves, from a cellular perspective. Topics covered include the ionic basis of ci r culation, respiration, excretion, digestion, sensory function, and cen- electrical excitability, the biophysics and molecular biology of ion tral processes of coordination. One hour of lecture, one hour of rec i t a - channels, and synaptic transmission. Additional topics include the tion and one three-hour laboratory per week. molecular regulation of key development events such as the emer- Pre re q u i s i t e s : BIO 328; CHE 132 or 133 gence of the neuronal phenotype, patterning of the nervous system, 3 credits, fall term, faculty and axon growth and path finding. The motor system is studied as an example of how molecular and cellular properties intermesh. This BIO 338 Self-organization of the Brain course is the first of a two semester sequence of courses intended to Exploration of basic neural and synaptic mechanism and the operation provide a broad and comprehensive basis for advanced study of the of representative brain circuits, using both theoretical approaches and nervous system. This course is primarily for graduate students. experimental evidence. Particular attention is given to Hebb’s Rule, its Prerequisite: BIO 334 or equivalent and permission of instructor cellular basis, its consequences for circuit self-organization, and its lim- 4 credits, fall term, faculty its. A solid background in a mathematical, physical, or biological sci- ence is desirable, but most relevant background material is covered in BN B 56 2 Motion: Motor Control and the Reflex Pathway the course. The physiology, development and molecular biology of motor systems Prerequisite: BIO 203 or CHE 132 or PHY 122 will be described. Basic aspects of the nervous system including ref l e x Advisory Prerequisite: BIO 334 ar cs, ion channels, gene expression and nerve growth are described in 3 credits, fall term, faculty the context of the spinal cord. 4 credits, spring term, faculty BIO 339 Molecular Development of the Nervous System An introduction to the molecular events that underlie development BN B 59 9 Re s e a r c h and plasticity of both the peripheral and central nervous systems, with Original investigation undertaken with supervision of a member of the a focus on neuronal mechanisms. Molecular and genetic approaches to st a ff . the analysis of neural induction, neuronal differentiation, neuronal Variable credit, fall and spring terms, faculty death and survival, neurotrophic factors, synapse formation and plas- ticity are presented. BN B 69 7 Advanced Neurobiology and Behavior Seminar Prerequisite: BIO 202 Seminar presentations delivered by faculty, associates, students and vis- Advisory Prerequisite: BIO 203 or 325 iting speakers. 3 credits, spring term, faculty 1 credit, fall and spring terms, faculty

BN B 44 6 Readings in Neurobiology and Behavior BN B 69 9 Dissertation Research Tutorial studies on recent advances in neurob i o l o g y . Original investigations undertaken as part of the PhD program under 1 credit, fall and spring term, faculty the supervision of the dissertation committee. Cr edits to be arranged, fall and spring terms BN B 48 6 Research in Neurobiology and Behavior 1-4 credits, fall and spring terms, faculty Department of Neurological Surgery BN B 54 7 Readings in Neurophysiology Discusses and evaluates neurophysiological res e a r ch published in bio- Chair: Raphael P. Davis (acting) logical journals. Provides critical analyses of techniques, methodology and conclusions of such res e a rc h . 1-3 credits, fall and spring terms, faculty Pro f e s s o r s : Joseph D. Fenstermacher (Emeritus), George W. Tyson, Harvey Wac h s m a n BN B 55 2 Neurobiological Tec h n i q u e s Aseries of laboratory exercises and lectures to give students “hands on” Associate professors: Raphael P. Davis, Michael Egnor, James V. experience in the basic laboratory techniques of contemporary neuro- Ma n z i o n e science. Includes intracellular and extracellular rec o r ding, neuronal tis- sue culture, neuroanatomical techniques, and integrative physiology. Assistant prof e s s o r s : Robert Galler, Jack Greenwood, Frederick B. 2 credits, fall term, faculty Gutman, Clemente T. Roque, Craig Rosenberg, Arthur Rosiel- lo, Robert G. Roth, Michael O. Sauter BN B 55 5 Ne u r o p h a r m a c o l o g y Develops an advanced understanding of neuropharmacology and res e a r ch. Introduces the nerve cell struc t u r e, synaptic and chemical I n s t r u c t o r s : Donna Andricopoulos, Marilyn Higgins, Mary transmission, and develops three themes of rec e p t o r s - r eceptors as chan- Lane, Jacqueline Paveling, Elaine Sepe, Nancy Strong, Patricia nels, and G-protein-coupled receptors. Recent advances in cell and mol- Wes t g a t e ecular biology provide the framework for instruction and discussion. Cr oss listed HBH 555. The Department of Neurological Surgery is an important clini- Pre re q u i s i t e : Faculty approv a l . cal component of the neurosciences program at Stony Broo k . 3 credits, fall term, faculty The objectives of the department are to provide the best possi- ble patient care while integrating a commitment to teaching and BN B 56 0 Laboratory in Neuroanatomy This course consists of a series of laboratory exercises and supplemen- ne u r oscience res e a r ch in the study of the etiology and prev e n - tal lectures providing an overview of the structural organization of the tion of nervous system diseases. nervous system. The mammalian nervous system and its sensory, The clinical faculty provide care to both adult and pediatric motor and cognitive components are emphasized. Laboratories include patients who req u i r e surgical treatment for a wide variety of examination of whole brains and histological sections, and some hands- ne u r ologic diseases. Selected residents from neurology and on experience with basic neuroanatomical techniques. Computer pro- su r gery programs serve on the neurological surgery service for grams illustrating the three-dimensional and circuit organization of the intensive exposure to the surgical management of neurol o g i c human brain are also used. disease, in particular trauma and more complex neuros u rg i c a l Pre r equisites: BIO 334 or equivalent and permission of instruc t o r pr oblems peculiar to an academic neuros u r gical practice. 2 credits, fall term, faculty Medical students receive lectures on a regular basis and are in s t r ucted on processes relating to the nervous system. Period-

131 ic pre-clerkship lectures are given with emphasis on cran- physcians for board certification in neurology. The residency iospinal trauma, cranial pres s u r e dynamics, central nervous training program provides a firm background in basic neuro- system tumors, and cereb r ovascular disease. Sponsorship is science disciplines and extensive exposure to clinical neurolo- also provided to qualified graduate students in the basic sci- gy. Residents complete separate rotations in neuropathology, en c e s . n e u ro r a d i o l o g y, child neurology and psychiatry and are encouraged to become involved in clinical and/or basic neuro- Department of Neurol o g y science research. Special postgraduate fellowship programs are available in areas such as clinical neurophysiology and pedi- Ch a i r : Patricia K. Coyle, acting atric neurology. The faculty also maintains a strong commitment to clinical Pro f e s s o r s : Mary R. Andriola, Anita Belman, Patricia K. Coyle, neurology through operation of the neurology service at Uni- Lauren B. Krupp, Nicholas J. Lenn versity Hospital and at the Northport Veterans Affairs Medical Center. Faculty research programs complement the clinical and Associate prof e s s o r s : Norman Chernik, Joel Delfiner, Michael academic functions of the department. Research in the depart- Eg o r , Oded Gerber, Mark A. Kaufman, Gary McAbee, Suparana ment of neurology covers a wide spectrum of activities in basic Ra j a m and clinical neuroscience, ranging from basic neuroanatomical, neurochemical and neurophysiological studies to basic and Assistant prof e s s o r s : Francis Antonawich, David Besser, Antho- clinical research in neuroimmunology, neurotoxicology, epilep- ny K. Bolton, Suranganee deLanerolle, Malcolm H. Gottesman, sy, neuroophthalmology and developmental neurobiology. Jack Greenwood, Mark Gudesblatt, Frederick Mendelsohn, Samson Mebrahtu, Henry Moreta, Richard A. Pearl, Patrick Department of Obstetrics, Gynecology Poole, Thomas E. Preston, Howard Reiser, Syed Rizvi, Steven and Reprod u c t i ve Medicine A. Rosen, Todd Rosenzweig, Joanna Smiroldo, Frances Taylor, Philippe D. Vaillancourt, Mark J. Zuckerman Ch a i r : J. Gerald Quirk

Instructors: Ann Marie Byers, Susan Vit a l e Pro f e s s o r s : J. An d r ew Fantl, David A. Baker, Anjzej Lys i k i e w i c z , Paul L. Ogburn Jr., Dev Maulik, Boris Pertrikovsky, J. Gerald The Department of Neurology includes Divisions of Pediatric Quirk, Martin L. Stone (Emeritus), Siamek Tabibzadeh, Linda Neurology, Clinical Neurophysiology and Neuropsychology, Tse n g as well as sections in Stroke, Multiple Sclerosis/Neuroim- munology, EEG, and Neuromuscular Diseases. The objectives Associate professors: Victor Alinovi, Frank Bonura, Richard A. of the Department of Neurology are three-fold. The depart- B ronson, Eva Chalas, John Chumas, George Farmakides, ment provides basic and clinical training in neurological sci- Reinaldo Figueroa, Mark I. Funt, Magdalen Hull, Cynthia ence to medical students, fellows and house staff. The intent of Kaplan, Daniel Kenigsberg, Alan Monheit, Alan Santos, Ellen this training is to provide a basis for scientific neurology and St e i n b e r g, Patrick F. Vet e r e, Robert R. Weiss, Yu-Kang Yin g practical instruction in patient care. The department carries on a broad program of research in neurological science and con- Assistant professors: Michael Arato, Melvin Berlin, Lauri Bud- tributes to the understanding of the structure, function and nick, Ann Buhl, Kristen Cain, Kent Chan, Maiguel Carrasco, diseases of the nervous system. The clinical faculty provide ter- Christine Conway, Valerie Cucco, Deborah M. Davenport, An n tiary, as well as basic, level clinical care in neurology, carried Do e r f l e r , James N. Droesch, Kathleen E. Droesch, An u r a d h a out within the context of medical student and house staff train- Dua, Kristi Egner, An d r ew Elimian, David Garry, Theodore L. ing. Go l d b e r g, Mitchell B. Goldman, Vinette Greenland, Todd Grif- Instruction is provided at all levels of medical education. fin, Abraham Halfen, Robert Hock, John Hunt, Robert Kaplan, Members of the department participate in the teaching of basic Elana Kastner, Steven A. Klein, David Krei n e r , Mary Kriner, neuroscience to medical students in pre-clinical years. A clini- Douglas S. Lee, Gary Levine, Michael Lydic, Philip J. Makows- cal clerkship and a selective (elective) in neurology are off e red ki, Charles T. Mann, Patrick McManus, Steven Milim, Noel O. during the clinical years. The clinical clerkship consists of an Mohammed, Seymour J. Molinoff, Ter esa Mular, Michelle Mur- intensive two-week inpatient experience in neurology during ph y , Hitesh Narain, Jerry Ninia, Robert O’Keefe, John Pallotta, the third year. The intent is to provide the student with the Hiramani R. Pardanani, Michael Pearl, G. Michael Peters, background to take a neurological history and carry out a neu- Antonia Pinney, Jeffr ey A. Porte, David Reavis, Steven I. Ross, rological examination in order to evaluate patients with neuro- Emanuel J. Rubin, Traci Saunders, Gabriel San Roman, Joy Sch- logical disease in an appropriate and logical manner. A selec- abel, David M. Shobin, Genevieve Sicuranza, Lawrence H. Tyd - tive (elective)in neurology is available to fourth year students ings, Fidel Valea, Ian VanPraagh, Robert N. VanSon, Malathy and consists of an intensive experience in the evaluation and Varanasi, Christian Westermann, Jerry Wid e r care of outpatients and inpatients in the active consultation ser- vices and specialty clinics such as those in pediatric neurology, Instructors: Susan Altman, Maureen Barbara, Eliot Birnbaum, multiple sclerosis, epilepsy and neuromuscular disease that are T h e o d o re Blaszczyk, Robin Bliss, Dana Bre n n e r, Kare n carried on by the department. The emphasis in this experience Coburn, Vivien Diaz-Barrios, Karen Dillinger, Eleanor Dunham, is on improving clinical diagnostic skills and the ability to for- Lance Edwards, Thomas Erhart, Gloria Escamilla, Marga r et Fis- mulate a plan of care for patients with neurological disease. ch e r , Susan Fish, Marie Frey , Sally Gambill, Michael Gentilesco, Attention is also directed to learning the techniques and inter- Stephen Golub, Jennifer Griffin, Richard L. Halpert, Val e r i e pretation of electroencephalography, electromyography and Infranco, Hamid Javidi, Arlene Kaelber, Debra Kittilsen, neuroradiological procedures, including tomography. Students Nicholas Kleopoulos, Christina Kocis, Robert H. Kramer, Laura are expected to participate in all aspects of the clinical activities Lesch, Paul Lograno, Morisa Marin, Linda Mahler, Jennifer of the department. Marshak, Careen Mauro, Michelle Mayer, Dayna McCauley, In addition to instruction of medical students, a three-year Brian McKenna, Dreux Patton, John Petraco, Gerardo San residency program is off e red to pre p a re postgraduate Roman, Gustavo San Roman, Philip Schoenfeld, Vera Seltzer,

132 Mindy L. Shaffran, Keith Sommers, Maxine Spicer, Karen Department of Ophthalmology Stampf, James Stelling, Susan Sterlacci, Dennis Strittmatter, Doris Weisman, Dina Weiss, Julie Wel i s c h a r , Joseph Xerri Ch a i r : Patrick A. Sibony

The Department of Obstetrics, Gynecology and Reprod u c t i v e Pro f e s s o r s : Craig Evinger, M. Cristina Leske, Nisson Schechter, Medicine is organized into the following divisions, each with its Patrick Sibony own chief: Gynecology and General Obstetrics, Gynecologic On c o l o g y , Maternal-Fetal Medicine, Reproductive Endocrinolo- Associate prof e s s o r s : Fadi El Baba, Stuart B. Fourman, Marcelle gy and Infertility, and Nurse Midwifery. Morcos, Elsa K. Rahn, Elinor Schoenfeld The department is responsible for instruction of medical stu- dents in each phase of their development. Assistant professors: Joseph Bacotti, Alfred J. Cossari, Marc During the second-year curriculum, the department partici- Dinowitz, Barry Golub, Robert A. Honkanen, William Kasaper, pates in the Introduction to Clinical Medicine course. Students Richard Koty, Maury A. Marmor, Eric Roberts, Gideon Sch- ar e taught male and female genitourinary physical examina- neck, Gerald S. Stoller, Pamela Weber, John Wittpenn tions in a program using prep a r ed “professional patients.” Fol- lowing the study of exam techniques utilizing audiovisual aids In s t r u c t o r s : Philip Bonanno, James F. Collins, Stephen Green- and pelvic models, small groups of students spend one session b e rg, Nancy Kwon, Jeffery Martin, Sidney Martin, John with a physician instructor and specially trained prof e s s i o n a l Romanelli, Scott Sheren, Eric T. Vinokur, Michael Weiner, Geof- patients who assist the individual student in conducting the frey Weisman, Lawrence Zweibel exam. The objective of the program is to provide an experience for The Department of Ophthalmology provides instruc t i o n / t r a i n - students to perform non-traumatic genital exams to minimize ing to both medical students and residents. Its faculty consti- the initial technical and psychological difficulties of the exam, tutes the only multi-specialty group practice on Long Island, and to introduce to them the importance of communication of fering the full range of ophthalmic subspecialties. Using the with their patients. most current diagnostic and therapeutic modalities in primary Second year medical students also have an intensive three - and subspecialty ophthalmology, the department rep r esents a week course in Reproductive Pathophysiology. Building on and complete clinical center for the testing/treatment of the gamut expanding the students’ knowledge of the basic sciences, this of ophthalmic disorders. Medical students and residents are course covers every aspect of human rep r oduction and the nor- thus given the opportunity to gain the necessary depth and mal and abnormal conditions of the male and female rep ro d u c - br eadth of education in ophthalmology. tive systems. The department provides the following clinical services that The Clinical Clerkship in Obstetrics and Gynecology is a six- reflect the faculty’s specialized expertise: week core curriculum presentation for students to become inti- mately involved with the ambulatory and hospital care of • General ophthalmology service female patients with pregnancy and/or diseases of the rep r o- • Ne u r o-ophthalmology service ductive tract. Educational objectives are attained thro u g h • Vit re o r etinal service didactic lectures, seminars, rounds, and clinical exposure - the • Cornea and anterior segment service latter essentially by integration into the service as a subintern. • Glaucoma service In addition to gaining experience with examination, diagnosis, • Oculoplastics and rec o n s t r uctive surgery service and principles of treatment, opportunities are provided for • Pediatric ophthalmology and adult strabismus ex p o s u r e to the preventive medicine aspects of the discipline, se r v i c e including family planning, adolescent guidance, cancer scree n - • Optometric se r v i c e ing, patient education and detection and prenatal health. For students already career oriented in obstetrics and gyne- These busy services are directed by members of the full-time co l o g y , and for those who desire greater depths than permitted fa c u l t y , all of whom are board certified and fellowship trained. by the core curriculum, fourth year electives are offe r ed in The faculty play an active role in the teaching of medical stu- maternal-fetal medicine (high-risk pregnancy), rep ro d u c t i v e dents, contributing to several of the organized teaching blocks. endocrinology and infertility, gynecologic oncology and gener- They participate in the first-year neuroscience course, in the sec- al gynecology and obstetrics. Participation in faculty res e a rc h ond-year rheumatology block, and in the third-year surgi c a l pr ojects as well as in independent student res e a r ch projects, uti- rotation. In addition, the department offers a two-to-four-w e e k lizing the department’s laboratory facilities in endocrinology, clinical clerkship in ophthalmology. im m u n o l o g y , fetal physiology, and virol o g y . The faculty participate in a fully accredited three-year joint The principal goal of the department is to train physicians residency with the Nassau University Medical Center. This who will maintain and improve the highest standards in training program has 12 residents, four of whom rotate at both women’s healthcare. University Medical Center and the Northport Veterans Aff a i r s Medical Center, and also contribute to the education of medical Re s i d e n c y st u d e n t s . The department offers an accredited four-year residency which The faculty contribute to the training of residents from includes training in all aspects of obstetrics and gynecology. other departments of the School of Medicine as well, including The program provides a struc t u r ed educational experience that the Department of Family Medicine, Department of Maxillofa- is planned in continuity with undergraduate and continuing cial Surgery, and Department of Emergency Medicine. In addi- medical education. Participants are aff o rded stru c t u re d , tion, neurology residents may elect to do a two-to-four week sequentially-developed exposures using a continuity of care rotation on the department’s neuro-ophthalmology service. model in the ambulatory and inpatient setting. This includes To enhance the experience of ophthalmology residents and primary medical management and a variety of surgical experi- to serve as an educational res o u r ce for Stony Brook’s medical ences appropriate to the level of training. students and residents, the department offers a series of open le c t u r es in ophthalmology.

133 Re s e a r ch participation within the department adds a valu- Department of Pat h o l o g y able dimension to its educational programs, demonstrating the faculty’s commitment to scholarly activity and the advance- Ch a i r : Jay L. Bock, ND, Acting Chair ment of ophthalmic knowledge and patient care. Pro f e s s o r s : Jorge Benach, Jay L. Bock, Arland L. Carsten, Eloy Among the research programs in which members of the Caracuel, Marianne Frieri, Berhane Ghebrehiwet, Dimitry faculty have recently been involved are: a multi-center clinical Goldgaber, Martha Furie, Gail S. Habicht, Mae Hultin, Jolyon trial for supplemental oxygen treatment for retinopathy of pre- Jesty, Darrel D. Joel, Marc Golightly, Bernard P. Lane, Leslie maturity; ultrasoniclysis of retinovascular thrombosis; a pre- Lukash, Kenneth Marcu, Frederick Miller (Marvin Kuschner liminary trial of pirfenidone in the treatment of proliferative Professor), Ute M. Moll, Lucien Nockomovitz, Nancy Peress vitreo-retinopathy; the establishment of a human eyelid move- (Emeritus), Mildred E. Phillips (Emeritus), Nancy Reich, San- ment laboratory; HIV-related studies; an evaluation of cataract ford Simon, Leon Sokoloff (Emeritus), Roy Steigbigel, Charles extraction in the Third World; a project involving corneal amy- Wetli loidosis; and a national study on ocular hypertension. Associate prof e s s o r s : Richard Bronson, John C. Chumas, Thomas S. Cottrell, Virginia Donovan, Howard Fleit, Dennis Galanakis, Department of Orthopaedics Alan Heimann, Philip B. Kane, Cynthia Kaplan, Jen H. Lin, Stanley Lipper (Emeritus), Sergey Lyubsky, Roberta Seidman, Ch a i r : La w r ence C. Hurst Eric Spitzer, Gary Zieve

Pro f e s s o r s : Marie A. Badalamente, Roger Dee, Martin A. Gru- ber, Lawrence C. Hurst, Clinton Rubin Assistant prof e s s o r s : Gary Clarke, Nolan Core, Stuart Dawson, David Durand, William Engellener, A n d rea Fleider, Mala Affiliated professors: Peter C. Altner, Kenneth J. McLeod, Bruce Gupta, Youjun Hu, Laura Katona, Richard Kew, A h m e d Meinhard, Leon Sokoloff (Emeritus), Jack T. Stern Khapra, Poonam Khullar, Sharon X. Liang, Jingxuan Liu, Edward Klein, Joseph Lanman, James S. Magidson, Prahba Pai, Associate professors: Hormozan Aprin, Steven P. Sampson, Peter Perrotta, Kanokporn Rithidech, Alan Schuss, Sylvia William T. Stillwell Spitzer, Katarina Szabo, Robert Trotta, George Turi, James Wil- son, Beverly Wyrick Assistant prof e s s o r s : Nestor Blyznak, Wesley V. Carrion, Mauro Cataletto, Jorge S. Cerruti, Weiliam Chen, Stuart Cherney, I n s t r u c t o r s: Joseph Chiofolo, Michael DeMartino, Steven Nicholas Divaris, Ernest Chisena, Frank DiMaio, Thomas J. Drexler, Lester Freedman, Stephanie Horowitz, Maria Plum- Dowling, Eric N. Dubro w, Jerry Ellstein, Joseph E. Farrell, mer, Patricia Schiller Leonard J. Figelman, A. Philip Fontanetta, Michael J. Fracchia, Robert Garroway, Kenneth Glass, P. Warwick Green, James P. The department is concerned with the pathogenesis of disease, Gurtowski, Susan Haralabatos, N. Pierre Helou, Richard O. as well as with its manifestations of diagnosis. The department Hindes, Frank Hudak, Bert Horwitz, Salvatore Inserra, Partap serves as a bridge between the pre- clinical and clinical sciences Khalsa, Stephen Kottmeier, Neil Kurtz, John Labiak, Paul C. for students, clinicians and non-clinicians at all stages of train- Lehmuller, John J. Leppard, Paul E. Levin, Jimmy Uy Lim, ing. It has responsibility for teaching students in each school of Enrico Mango, Robert Michaels, Mohammed Ather Mirza, the Health Sciences Center, in the College of Arts and Sciences, Carlos F. Montero, Jeffrey S. Muhlrad, Craig B. Ordway, Seth and in the Graduate School, and has responsibility for the post- Paul, James Penna, Stuart B. Polisner, M. Pierre Rafiy, Richard graduate and continuing education of residing physicians, Rogachefsky, Louis Romeo, Paul M. Ross, Mark Stephen, Yan- house staff and practitioners. In addition to its teaching res p o n - Qun Sun, Glenn Teplitz, Jay Wagner, Edward Wang, Carl sibilities, the department operates the hospital laboratories. At Weiss, Leonard S. Weiss, Paul Yerys the graduate level, programs leading to the PhD degree are developed within the department and in cooperation with Instructors: Robert Biaggi, Jeffrey A. Bonneville, Noah S. Finkel, other departments. A. Philip Fontanetta, Mark Goldberg, Bruce S. Goodman, Mar- shall Katz, Warren Kent, Martin Mandelbaum, Ross Mittiga, Co u r s e s Andrew H. Meyers HB P 31 0 Pa t h o l o g y Orthopaedics is concerned with the pathology and physiology Studies the basic mechanisms of disease and the pathophysiology of the of the musculoskeletal system. Clinical divisions include chil- important illnesses of man. Primarily for Health Sciences students; oth- dren’s orthopaedics, hand surgery, foot surgery, micro surgery, ers admitted with special permission. joint replacement and reconstruction, spine surgery, sports Pre re q u i s i t e s : Permission of instruc t o r , BIO 151 and 152. medicine and trauma. Research divisions include laboratories 3 credits, fall modules 3-6, Dr. Furie for the study of neuromuscular biology. Lectures in orthopaedic surgery and elective rotations are HB P 39 0 Basic Mechanisms in Pathology provided for students in the School of Medicine. The depart- Molecular mechanisms underlying human diseases. Includes inflam- ment supports a fully accredited residency program in mation, coagulation mechanisms, fibrinolysis, immunological defenses, orthopaedic surgery, and post-residency fellowships in hand vi r uses, oncogenes, and cancer. surgery. Pre re q u i s i t e s : BIO 361 or BIO 362 req u i r ed. Cell Biology and Genetics The research divisions provide training on an elective basis rec o m m e n d e d . for students and orthopaedic residents in the School of Medi- 3 credits, spring term, Dr. Fliet cine. HB P 393, 394 Special Topics from the Pathology Literature Tutorial readings in pathology, with periodic conferences, reports, and examinations arranged with the instruc t o r . Pre re q u i s i t e : Permission of supervising instruc t o r . 1-2 credits per term, fall and spring terms, staff

134 HB P 398, 399 Research Project in Pathology HB P 55 3 Pathology of Neoplasia An independent re s e a rch project under faculty supervision, that Studies the nature and behavior of neoplastic tissue, the etiologies of emphasizes the principles of experimental design, data collection, eval- ca n c e r , the effect of tumors upon the host. Includes laboratories to uation of findings, and reporting of results. Project report req u i r ed. May acquaint the student lacking a background in histology or physiology be rep e a t e d . with the appearance and behavior of cancer on the tissue and orga n Pre re q u i s i t e s : Laboratory experience and permission of the supervising le v e l . in s t ru c t o r . Pre re q u i s i t e : Permission of instruc t o r . 0-4 credits per term, fall and spring terms, staff 2 credits, spring module 8, course coordinator: Dr. Miller

HB P 40 1 Applied Immunology HB P 55 4 Advanced Immunology In t r oduces the principles of immunology for allied health prof e s s i o n s Selected topics in immunology are discussed using original res e a r ch lit- students. Emphasizes applications of immunological principles to clin- er a t u r e as the central focus. Students present and discuss the literature ical and laboratory immunology. in a seminar format. Pre re q u i s i t e : Biology or Pre-Med major, or enrollment in School of Pre r equisite: HB P 531 or 533 and permission of instruc t o r Health Technology and Management. 2 credits, spring term, Drs. Fleit, Habicht and Miller 3 credits, spring modules 5 and 6, Dr. Golightly HB P 55 6 Laboratory Medicine HB P 41 1 Applied Pathology A fo u r -week full-time (6 hr/day) course dealing with clinical laborato- For physician assistants, advanced nursing students and other allied ry decision making and the basis for the laboratory evaluation of health profession students who are concurrently reg i s t e r ed in HBP 31 0 human evaluation of human disease. Didactic and practical pres e n t a - or who have demonstrated mastery of that material. Extends the range tions by interdepartmental faculty. Intended principally for senior med- and depth of HBP 310 with emphasis on clinical application. Limited ical students, but also for advanced microbiology or biochemistry stu- en r ollment with permission of the dean. dents interested in clinical applications. 1 credit, fall modules 3-6, Dr. Galanakis Pre re q u i s i t e : Permission of instruc t o r . 6 credits, spring module 5, Dr. Bock

HB P 51 1 Pa t h o b i o l o g y HB P 56 1 Electron Microscopy for Experimental For graduate students who have obtained primary healthcare baccalau- Pa t h o l o g i s t s reate degrees through the case study approach. Covers the underlying Uses electron microscope (EM), alone and in conjunction with other principles of modern experimental pathology. Focuses on the clinical methodologies in studies of biological dysfunction. Special techniques aspects of the body system, including relevant underlying biochemistry, include histochemistry, enzyme histochemistry, immunohistochem- st ru c t u r e, or pathophysiology at the organ, tissue, cell or molecular is t r y , diffraction, stereo-EM and scanning EM. Design of prot o c o l s , le v e l . pr eparation and interpretation of data. Pre re q u i s i t e s : Un d e r graduate degree, healthcare experience, biochem- Pre r equisite: Permission of instruc t o r . istry or cell biology, anatomy and microb i o l o g y . Variable credits, 2-6 per term, fall and spring terms, Dr. Lane 3 credits, fall modules 3-6, Dr. Galanakis HB P 58 0 Teaching Honors HB P 53 1 General Pathology Selected students whose performance in the basic req u i r ed courses for In t r oduces the nature and causes of disease, death, reaction to injury, the graduate program is in the top 10 percent conduct tutorials for first- and rep a i r . Analyzes associated structural changes in cells and tissues, year graduate students in the program and other students taking grad- with ref e r ence to their functional correl a t e s . uate courses for credit. The tutors are supervised and graded by pro- Pre re q u i s i t e s : Hi s t o l o g y , gross anatomy, physiology and biochemistry, gram faculty of the graduate program. Successful completion of this prior or concurrent microbiology or permission of instruc t o r . course will make the students eligible to receive an “Honors in Tea c h - 3-6 credits with lab, 3 credits without lab, spring modules 5-8, course coordi - ing” on their transcript. nator: Dr. Fleit Pre re q u i s i t e : Permission of instruc t o r . 1 credit, fall and spring terms, graduate program faculty HB P 53 2 Medical Immunology In t r oduces the principles of immunology for professional students, HB P 59 0 Seminars in Immunology including definition of antigens and antibodies, description of cellular A series of monthly seminars focusing on res e a r ch in prog r ess by the events in the immune response, theories of antibody formation, mecha- participants, current journal articles in the field of immunobiology, and nism of inflammation, hypersensitivity states, and diseases associated pre p a r ed reviews of specified areas in the general field. with responsiveness of the immune system. Pre r equisite: MCB Graduate Students Pre re q u i s i t e s : Advanced course in biology, biochemistry, genetics and 1 credit per term, fall and spring terms, staff; course coordinator: Dr. Fleit histology or taken concurrently and permission of the instruc t o r . 2 credits, spring modules 5-6, course coordinator: Dr. Miller HB P 62 2 Clinical Pathologic Correlations: Gross Pathology HB P 53 3 Im m u n o l o g y Co r r elative exercises in clinical pathology and human gross anatomic Principles of immunology for graduate students in the biological sci- pathology including surgical biopsy material. Open to students in med- ences, including definition of antigens and antibodies, specificity of the ical sciences. immune response, immunoglobulin stru c t u re, the genetics of Pre r equisites: Systems pathology and general pathology course. Permis- immunoglobulin synthesis, cellular cooperation in the immune sion of instruc t o r . response, hypersensitivity, tolerance immunogenetics. Open to Variable credits, 1-3, fall term, course directors: Drs. Kane and Miller advanced undergr a d u a t e s . Pre r equisites: Advanced courses in biology and biochemistry, and per- HB P 69 1 Journal Club in Pathology mission of instruc t o r . Pr ovides students with a forum for acquiring skills involved in the crit- 3 credits, fall term, course coordinators: Drs. Fleit and Habicht ical analysis and presentation of scientific data by active participation in seminars of major topics in cellular and molecular pathology, and criti- HB P 546 Human Disease: Mechanism in Therapy cal discussion of selected topics with presentation of papers from the lit- Human disease will be studied at biochemical and molecular cell lines. er a t u re . Aspects of mechanism will be considered with particular attention to Pre re q u i s i t e : MCB graduate students pathoenesis and therapeutic intervention. Cross-listed with HBH 546 1 credit, fall and spring terms, Dr. Kew and BMO 546. Pre re q u i s i t e s : Ap p r oval of instruc t o r HB P 96 6 Hematology Conference 3 credits, spring term, staff Teaches a given aspect of hematology, oncology or immunology. Staff fr om medicine, pathology, and nuclear medicine participate, and usual-

135 ly presents a case to introduce the subject. Various teaching aids, such Department of Ped i a t r i c s as review of pathological material, are used. Primarily for health sci- ences prof e s s i o n a l s . Ch a i r : Ri c h a r d N. Fine Pre re q u i s i t e : Permission of instruc t o r . Variable credits, 1-2, fall, spring and summer terms 1 and 11, staff (medicine, pathology and nuclear medicine) Pro f e s s o r s : David Annunziata, Stephen Baumgart, Thomas M. Biancaniello, Janet E. Fischel, Marion Castro-Magano, Jonathan HB P 96 7 Tumor Conference Davis, Gabrielle Carlson, Richard N. Fine, Hossein Ghadimi, Considers problems in the management of patients with a malignancy Joseph Greensher, Donald Gromisch, Martin Gruber, Avinash and recommendations for a course of therapy for each patient including C. Jerath, Nicholas Lenn, Ronald V. Marino, Howard C. Mofen- a review of a particular aspect of cancer treatment or natural history in son, Margaret M. Parker, Robert I. Parker, Cedric J. Priebe, War- depth. Functions as the link between the hospital and the Eastern ren N. Rosenfeld, Leonard Rosenzweig, Alan Spitzer, Grover J. Oncology Cooperative Group. Primarily for health science prof e s s i o n - Whitehurst, Thomas Wiswell al s . Pre re q u i s i t e : Permission of instruc t o r . Variable credits, 1-3, fall, spring and summer terms 1 and 11, staff Associate professors: Walter Backus, Eleni Bacola, Anita Belman, Alma Bicknese, John B. Branche, Mary Cataletto, Latha Chan- HB P 96 8 Advanced Clinical Pathologic Correlations: dran, Anupama Chawla, Mariano Lev Chernobilsky, Peter Gross Pathology Ciminera, Joseph D. DeCristofaro, Leo Dvorken, Marian J. Postgraduate correlative exercises in human gross pathologic anatomy Evinger, Fred Ferguson, Hershel H. Glatt, Cynthia Kaplan, that emphasize the gross pathologic basis for altered function and clin- Stephen Katz, Harvey Kolker, Marion L. Koomey, Haesoon ical manifestations of disease. Open to physicians and others with Lee, Boris Lustik, V. T. Maddaiah, Steven A. Maitinsky, advanced degrees in medical sciences. Leonard Marino, Seymour B. Musiker, Sharon A. Nachman, Pre re q u i s i t e : Permission of instruc t o r . Variable credits, 1-3, fall and spring terms, Dr. Kane Pramod Narula, Michael Nussbaum, Stephen Parles, John C. Pomeroy, Leslie Quinn, Irwin L. Schwartz, Jack Sherman, HB P 96 9 Anatomical and Surgical Pathology for Thomas Smith, Richard Sosulski, Peter S. Tolins, Rita P. Verma, Residents in Pathology David Volkman, Robert Wasnick, Thomas A. Wilson To provide practical and clinical experience in tissue pathology. During the four week elective the student is given the opportunity to partici- Assistant prof e s s o r s : Renu R. Aggawal, Milton Agulnek, Arie pate in all aspects of autopsies as well as gross and microscopic exami- Aloni, Richard Ancona, Jane Aronson, Viswanathan Balachan- nation of surgical specimens. There is ongoing review of general and dar, Howard Balbi, Alexander Benitt, Rachel A. Bergeson, Har- or gan system pathology to rei n f o r ce structural-functional correl a t i o n s . vey Bernstein, William H. Bikoff, Robyn Blair, Denise Blum- This elective is selected by students who plan a career in pathology as a “hands-on” introduction to the specialty. The elective is also chosen by berg, John F. Bisocco, Harriet S. Boxer, Ivy I. Boydstun, William others, particularly individuals who will enter radiology, and who seek B r y s o n - B rockman, Jose Canas, Shang Yao Chen, Thulasi to correlate radiographic and pathologic anatomy. Students who are Cheruvanky, Cathy Coleman, John A. Colucci, Rebekah B. su f ficiently interested and motivated may become involved in rel a t i v e - Conroy, Hema Dalal, Christopher DeSanto, Mehmet Yilmaz ly independent work-up of selected cases. Primarily for health sciences Dincsoy, Charles J. Dunn, Michael Egnor, Nelson S. Erhart, pro f e s s i o n a l s . Juan Espinoza, Stanley Everett, Kimberley Fenton, Robert Pre r equisite: Permission of instruc t o r . Festa, Mayte Figueroa, Damian Forletti, Patricia Galvin-Parton, Variable credits, 1-3, fall, spring, summer terms, Dr. Kane Blanca R. Gamboa, Polina S.Gelfer, Lynda L. Geller, Moham- mad Ghofrani, Louis M. Goldblum, Abby J. Greenberg, Susan HB P 97 0 Gross Neuropathology This elective is intended to expose the student to what it means to be a Gunduz, Susan Guralnick, Gerald R. Hartman, Martin Haupt- ne u r opathologist and to allow the student to read and directly study man, David Hyman, Sharon L. Inkeles, George M. Johnson, major diseases of the brain, spinal cord, nerve and skeletal muscle. The Ivan Kalina, Martin P. Kaplan, Eileen Kelly, Scott M. Klein, focus of such study will be individualized. Available to the student will Mitchell Kleinberg, Sujatha Kosuri, Leonard Kristal, Mark J. be (1) attendance at two weekly neuropathology autopsy brain clinical Kropf, Andrew H. Lane, Edward Langenback, Betty Chi-mei co r r elation conferences held at University Hospital and at the Suffo l k Lee Kuo, Marvin A. Lieber, Mark S. Lowenheim, Boris Lustik, County Medical Examiner’s Office in Hauppauge (2) individual autop- Susan Mangiameli, Daniel Mayer, Carolyn Milana, Peter sy brain case assignment with attending student review and case sign- Morelli, Lisa Mueller, Richard Nickerson, Divna Nikolic-Djolic, out. (3) Neuros u r gical, neuropathological rotation to include: review of Bettina Niederer, Patricia Nolan, Ellen Oppenheimer, Jagan N. films and patient data, participation in frozen section diagnosis and final neuros u r gical sign out (at University Hospital only). (4) focus on Pahuja, Anil G. Palekar, James Parles, Kalpana Patel, peripheral nerve and skeletal muscle to include independent review of: Ammukutty Paulose, Paul H. Penzer, Lucy Pontrelli, Devina clinical findings, muscle histochemistry, routine micros c o p y , electron Prakash, Prasanthi Reddy, Frederick J. Reindl, Carolyn Rob- mi c ro s c o p y , teased fiber preparations and immunofluorescence to be bins, Irina Rubin, Dominick Sabatino, Richard Salo, Arnold W. followed by participation at final case review and sign-out with neu- Scherz, Howard Schreiber, Arthur J.Schwager, Michelle Seitz, ropathology attending (at University Hospital only). (5) independent Jila harif, Saroja Siddharth, Robbyn Sockolow, Yosef Soley- study of study sets, which include Kodachrome sets and micros c o p e mani, Daniel E. Sloniewsky, Neelkamal S. Soares, Alfred I. slide sets by topic (at University Hospital only). Spieler, Shanthy Sridhar, Raphael Strauss, Behzad Talebian, Pre re q u i s i t e : Permission of instruc t o r . Catherine E. Tayag-Kier, David H. Tegay, Liliana Tique, Joseph Variable credits, 1-3, fall, spring, summer terms, Dr. Seidman HB P 97 1 Renal Clinicopathologic Correlations Thomas, Janice Valmassoi, Nora E. Wecker, Dilys A. Whyte, Acase-oriented, postgraduate course in renal biopsy interpretation and Santiago A. Wong, Janaki Yadlapalli, Barbara Young, Rose its relationship to patient management. Marie Young Pre re q u i s i t e s : MD or PhD degree and clinical experience. 1 credit, fall, spring and summer terms, Dr. Miller In s t r u c t o r s : Albert Adler, Farzana Ahsan, Keith Ancona, Taik Yong Ban, Lena Baram, Donna Baranek, Laura Bennett, Stuart Berman, Jennifer Byrne, Teresa Carney, Siobhan Cassidy, Lisa Clark, Jennifer Clark-Natasi, William W. Colden, Jean Connor, Zenaida Cruz, Michell Davi, Traci Downs, Agboola O. Fatire- gun, Ada Fenick, Jay A. Freed, Laurence J. Galinkin, Ilene Goldstein, Jeanne Greenfield, Jack M. Greenwood, Deborah

136 Guigliano, Celso Licelar Hofillna Jr., Mohinder K. Guram, Jen- Pro f e s s o r s : Paul R. Adams, Daniel Bogenhagen, Moises Eisen- nifer Haimowitz, Darius Holmes, Harriet Hellman, Claudia berg, Paul Fisher, Francis Johnson, Craig C. Malbon, Roy Steig- Herbert, Debra Hickey, Celso Hofelena, Roy Horowitz, Ken- bigel, Joel Sussman, Masaru Takeshita (Emeritus), Stephen neth G. Huml, Kerry Gallagher- Walsh, Gail Kaden, Susan Vitkun, David L. Williams Katz, Mitsu A. Kee, Michele Kelly, Nikhat S. Khan, Jason Kro- nberg, Bernard Lau, George V. LoVece, Rosemary Mahan, Associate prof e s s o r s : Miguel Berrios, Laura Fochtmann, Michael Richard E. Manners, Phyllis Marion, Paul Martinez, Kumar A. Frohman, Charles Iden, Caroline Kisker, Masaaki Moriya, Mecheri-Madom, Patricia Mele, Maria Mineo, Pamela Minett, Sidonie A. Morrison, Joav Prives, Shinya Shibutani Stephan Nagler, Jeanmarie A. Napolitano, Tulika Narain, Roberta Nataloni, Magalena Oleszak, Fernando Ordonez, Marc Assistant pro f e s s o r s : Roger Cameron, Margery Connelly, Ovadia, Linda H. Perangelo, Mihailo Petrovic, Linda H. Ponz- Howard Crawford, Carlos de los Santos, Dax Fu, Holly Miller, er, Shahina Qureshi, Sarala Radhakrishnan, Youchan Rhee, Thomas Rosenquist, Styliani-Anna Tsirka Carlos J. Rivera, Anne Rohan, Lisa Romard, Dov Rosen, Debra Sansoucie, Despina Scheyer, Anna Schwartz, Patricia Schwarz, Adjunct professors: Rodney Bednar, Richard Miksicek, Fernan- Barbara Seifert, Reid Selden, Marjorie Serotoff, Foqzia Siddiq, do Salles, Sidney Strickland Arlene Smaldone, Tracey L. Spinnato, Michael P. Stein, Karen Sulitzer, Rohit Talwar, Alexander A. Tocher, Geraldo Tolentino, Instructor: Kimberly Conlon, Daryl Henderson, Fayanne Robert Trepel, Decerina Uy, Mona Vani, Barbara Wieder, Ian Thorngate Winkler, Maicie M. Wong, Catherine Zillmann Pharmacology is an interdisciplinary science that deals with The Department of Pediatrics provides medical students with theeffects of chemicals on biological systems. Faculty research a number of educational offerings. In the preclinical educa- interests emphasize the molecular mechanisms of the action of tional years, we participate in the first year course providing drugs, hormones, and toxins. Teaching is directed towards an students with an introduction to clinical medicine, and faculty understanding of the basic principles underlying the therapeu- participate in second year course teaching. In the third year of tic and toxic actions of drugs and chemicals. undergraduate medical education, pediatrics is among the The department provides instruction for professional stu- required rotations, and students participate in the clinical eval- dents in the schools of the Health Sciences Center and offers uation and care of patients from birth through adolescence. graduate and upper-division courses in pharmacology, toxicol- Senior year rotations may be selected from an array of offerings ogy, and therapeutics. An undergraduate pharmacology pro- in the pediatric subspecialties as well as general pediatric med- gram is provided through the College of Arts and Sciences. icine in the format of subinternship and elective month-long courses. Co u r s e s The pediatric teaching program is a three-year program designed to provide a solid foundation for clinical practice or HB H 33 0 Fundamentals of Pharmacology I for further study in the pediatric specialties, including pedi- Covers the basic principles that underlie the action of drugs on physio- atric research. logical processes. These principles are applied to the specific action of The program emphasizes basic principles of scientific med- dr ugs on the autonomic nervous system. In addition, the pharmacolo- gy of cardiovascular drugs are covered in detail. icine and reasoning and treats pediatrics as an organic contin- 2 credits, module 3, Dr. Prives uum in which the individual pediatrician must function to coordinate complex systems of disease prevention as well as HB H 33 1 Fundamentals of Pharmacology II treatment. Special emphasis is placed on community and A continuation of HBH 330. Covers the action of drugs on individual ambulatory practice. systems as well as drug - d r ug interactions emphasizing the mechanisms The program is based at University Hospital, which pro- of drug action. Surveys therapeutic applications and adverse drug rea c - vides 40 pediatric beds, 10 Pediatric Intensive Care (PICU) ti o n s . beds, 40 newborn intensive care beds, 30 bassinets and active Pre r equisite: HBH 330 ambulatory care, including the Urgent Care Center. In addi- 3 credits, modules 4-6, Dr. Prives tion, the service operates in the Coram Health Center, an HB H 33 2 Pharmacology in Cardiorespiratory Sciences ambulatory care center of Suffolk County; in the University Includes the basic principles of drug actions and covers drug applica- Health Service, for adolescent medicine; and in satellite affili- tions in the autonomic, cardiovascular and respiratory systems. For ates in Central Islip, East Moriches, East Setauket, Patchogue, ca rd i o r espiratory sciences students enrolled in the School of Health Southold, and the Cody Center for Autism & Developmental Technology and Management. Disabilities, which together provide for 65,000 ambulatory 3 credits, modules 3, 4, not offered all semesters, Dr. Prives encounters per year. Elective experiences are available in all fields of pediatrics, HB H 393, 394, Topics in Pharmacology* either at University Hospital or at affiliated programs at Nas- Tutorial readings in pharmacology with the periodic conferen c e s , reports and examinations arranged with the instruc t o r . Open to third sau University Medical Center or Winthrop University Hospi- and fourth year students. tal. Pre re q u i s i t e : Permission of the instruc t o r . 1-5 credits per term, fall and spring terms, staff

Department of Pharmacological Sciences HB H 396, 398, 399 Research Project in Pharmacology** Independent res e a r ch under faculty supervision, emphasizing princi- Ch a i r : Jeffrey E. Pessin ples of experimental design, data collection, evaluation of findings and reporting of results. Project report req u i r ed. May be rep e a t e d . Distinguished prof e s s o r s : Seymour Cohen (Emeritus), Arthur P. Pre re q u i s i t e s : Laboratory experience and permission of supervising in s t ru c t o r . Grollman, William vander Kloot (Emeritus), Edward Reich 1-6 credits per term, summer, fall and spring terms, staff ______**Arts and Sciences students may receive no more than a total of six *Joint Appointment, Cold Spring Harbor Laboratory cr edits in one term of any combination of courses numbered HBH 393 th r ough 399.

137 HB H 53 1 Principles of Medical Pharmacology target interactions by X-ray crystallography and NMR spectroscopy as Basic principles that underlie actions of drugs on physiological proc e s s - a basis for the design of new drugs will be discussed on the basis of es with particular ref e r ence to their therapeutic and toxic actions. Pri- very recent examples. Advanced computer simulation techinques will marily for medical, dental and graduate students. be discussed and will include the use of molecular mechanics energy Pre r equisites: Ph y s i o l o g y , biochemistry, and permission of instruc t o r . functions to optimize biomolecular structures, predict ligand binding 5 credits, modules 4-6, Dr. Frohman and staff modes and energetics. Prerequisite: Permission of instructor, Dr. Kisker HB H 54 5 Biochemical Laboratory Tec h n i q u e s Fall semester, 1 credit, ABCF grading In t r oduces theoretical principles and experimental techniques used in modern biochemical res e a r ch. Lectures and demonstrations pres e n t HBH 633 Physiological Action of Drugs topics in laboratory computers, chrom a t o g r a p h y , nuclear magnetic res - Selected applications of drugs used in clinical medicine, illustrating onance, mass spectrom e t r y , protein sequencing, cloning technology, current concepts and problems at the intersection of pharmacological sedimentation, electrop h o r esis, and ligand binding. Includes proc e - basic science and therapeutic treatment. Settings to include the mana- du r es for the safe handling of toxic chemicals and radioisotopes. gaement of obesity, psychiatric disease and cardiac disease. Pre re q u i s i t e : Permission of instruc t o r . Prerequisite: Permission of instructor, Dr.Frohman 3 credits, fall term, Dr. Bogenhagen and staff Fall semester, 1 credit, ABCF grading

HB H 55 3 Signal Tra n s d u c t i o n HBH 634 Chemical Manipulation of DNAMetabolism The course will emphasize fundamental concepts in signal transduction This course will focus on drugs that act by inhibiting DNA synthesis, (e.g. membrane-protein and prot e i n - p r otein interactions, amplification including inhibition of precursor synthesis. The course will include signals) and individaul lectures will apply these concepts at each stage original research papers on biochemical mechanisms and clinical of cell signaling from the cell surface to the nucleus, where signal trans- applications of antiviral and anti-cancer therapeutic agents. duction leads to specific gene expression. Crosslisted with HBY 53 3 . Prerequisite: Permission of instructor, Dr. Fisher ABCF grading. Spring semester, 1 credit, ABCF grading 3 credits, spring term / odd years, staff HBH 635 New Concepts in Chemotherapy HB H 58 0 Selected Topics in Pharmacology This course compares mechanisms of action of drugs used for antibac- Student seminars and readings on topics arranged through consultation terial and anti-cancer chemotherapy. The lecture material stresses how selective toxicity is achieved to obtain cytostatic or cytotoxic effects. with staff. Original research papers are discussed on drug-induced apoptosis, Pre re q u i s i t e : Permission of instruc t o r . mechanisms whereby cells develop reisitance to chemotherapy and Variable and repetitive credits, 1-8 per term, fall and spring terms, staff novel strategies to overcome this resistance. Prerequisite: Permission of instructor, Dr. Bogenhagen HB H 59 0 Pharmacology Seminars Spring semester, 1 credit, ABCF grading Advanced res e a r ch seminars by staff and visiting lecturer s . Pre re q u i s i t e : Permission of instruc t o r . HBH 636 Drug Discovery and Toxicity 1 credit, repetitive, fall and spring terms Drug Discovery and Toxicity will present methods used to identify new drug candidates and how these substances may be modified chemically to construct active drugs with excellent pharmacodynamic HB H 59 9 Graduate Research in Pharmacological Sciences and pharmacokinetic properties. Toxicity of drugs and new drug com- Original res e a r ch projects under faculty supervision. pounds will be explored using studies of specific drugs. Toxic respons- Pre r equisite: Permission of instruc t o r . es that appeared in the general population and mechanisms leading to Variable credits, 1-12 per term, fall, spring and summer terms, staff toxicity will be discussed. Prerequisite: Permission of instructor, Dr. Iden HB H 601 Practicum in Teaching Pharmacology Spring semester, 1 credit, ABCF grading Practical experience and instruction in the teaching of pharmacology carried out under faculty orientation and supervision. HB H 65 5 Ne u r o p h a r m a c o l o g y Pre re q u i s i t e : Permission of instructor and full-time graduate status An advanced course for graduate students interested in developing an 1 credit, fall and spring term understanding of neuropharmacology and res e a r ch on this topic. Fol- lowing a general introduction to the nerve cell struc t u r e, synaptic and HBH 631 Principles of Drug Action chemical transmission, three themes receptors, receptors as channels This course is designed to provide a quantitative understanding of the and G-protein-coupled rec e p t o r s - a r e developed. Recent advances in basic principles by which drugs interact with living systems at the cel- cell and molecular biology provide the framework for instruction and lular and organismal levels. Topics include the mechanisms of drug discussion. Crosslisted with BNB 655. transport through membranes, interaction of drugs with receptors and Pre r equisite: Permission of instruc t o r binding proteins, drug distribution, biotransformation of dru g s , enzymes of stage I and stage II metabolism, cytochrome p450 gene 3 credits, fall term, Dr. Morris families and regulation of p450 gene expression, mechanisms of renal excretion of drugs and metabolites, pharmacokinetics of constant drug HB H 66 0 Research Proposals in Regulatory infusions and intermittent dosing regimens, and application of phar- Bi o l o g y macokinetic principles to protein and mRNAinduction and turnover. A special topics course in which faculty present current res e a r ch pro- Students apply parmalocical principles in a series of problem-solving posals for discussion and critical rev i e w . Students develop short exercises. res e a r ch proposals for their midterm evaluation and present a full Prerequisite: Permission of instructor, Dr. Williams res e a r ch proposal for the final evaluation. The goal of this course is to Fall semester, 1 credit, ABCF grading help students develop the skills req u i r ed to design, present and defend HBH 632 Molecular Interactions of Drug Structures a focused res e a r ch plan. Since proposals developed during this course This course provides an overview of the most current approaches to form the basis of a student’s Qualifying Exam, registration is limited to analyze and understand the interactions between a drug and its target students in the Graduate Program in Molecular and Cellular Pharma- and how this information is used for the design and development of co l o g y . new drugs. The individual lectures will cover the use of microarray Pre re q u i s i t e : Graduate biochemistry, molecular genetics, cell biology. technology for broad gene expression analysis and to analyze differen- Pr evious or concurrent registration in Principles of Pharmacology I and tial gene expression for therapeutic gene target identification. Bioin- II . formatics will be used as a tool for homology searches, especially in 3 credits, spring term light of the genome projects. The detailed structural analysis of drug

138 HB H 686 Minicourse: Advanced Seminars in Ph a r m a c o - BC P 40 0 Writing in Pharmacology logical Sciences See req u i r ements for the major in pharmacology, upper-division writ- Aseries of five to six lectures by members of the Stony Brook faculty in ing req u i r ement. Satisfactory/Unsatisfactory grading only. conjunction with distinguished outside speakers on topics of curren t Pre r equisites: Pharmacology major; upper-division standing Fall and spring, 0 cred i t s importance in pharmacology and related areas of biochemistry, molec- ular biology, and cell biology. BC P 40 1 Principles of Pharmacology 1-2 credits, fall and spring term Basic principles and mechanisms of drug distribution, absorption, metabolism, and elimination. Principles of chemical carcinogenesis and HB H 66 9 Thesis Research in Pharmacology tumor promotion. Autonomic, smooth-muscle, and CNS pharmacolo- Original investigation undertaken as part of the Ph.D., program under gy . Pharmacology of specific drugs of historical interest including alco- supervision of thesis adviser and committee. hol, antibiotics, aspirin, nicotine, and morphine. Review of anticoagu- Pre re q u i s i t e : Permission of thesis adviser. lants and thrombolytic agents, antiparasitics, and drugs for the trea t - Variable and repetitive credits, 1-12 per term, fall and spring terms ment of allergic conditions and gout. Pre re q u i s i t e s : BIO 362; CHE 322 and 327; a G.P.A. of 3.0 or higher in these HBH 69 9 Dissertation Research on Campus courses and their prere q u i s i t e s Original investigation undertaken as part of the Ph.D., program under Co re q u i s i t e : BC P 403 supervision of thesis adviser and committee on site, where major por- Fall, 3 cred i t s tion of their res e a r ch will take place on Stony Brook University Cam- pus, Cold Spring Harbor or Brookhaven National Laboratory BC P 40 2 Advanced Pharmacology Pre re q u i s i t e : Permission of thesis adviser. Advanced concepts of drug metabolism, pharmacokinetics, biochemi- Variable and repetitive credits, 1-12 per term, fall and spring terms cal and molecular mechanisms of drug action, and drug resistance in human disease states. Toxicological agents and environmental pollu- HBH 70 0 Dissertation Research in Pharmacology off tants. The pharmacology of autocoids, anti-inflammatories, immuno- Campus - Domestic su p p r essants, and antiasthmatics. Rational drug design and drug rec e p - Original Investigation undertaken as part of the Ph.D., program under tor interactions using computer molecular modeling techniques. supervision of thesis adviser and committee off site, and is to be reg i s - Pre re q u i s i t e s : BC P 401 and 403 te r ed for when a major portion of the student's res e a r ch will take place Co r equisite: BCP 40 4 of f-campus but in the United States and or United States provinces. Spring, 3 cred i t s Pre re q u i s i t e : Permission of thesis adviser. Variable and repetitive credits, 1-12 per term, fall and spring terms BC P 40 3 Principles of Pharmacology Laboratory The use of computer software for data collection and analysis. Illustra- HBH 70 1 Dissertation Research Off tions of the principles of drug absorption, distribution, metabolism, and Campus - International elimination. In vitro assays that demonstrate dose response rel a t i o n - Original Investigation undertaken as part of the Ph.D., program under ships. Principles of bioassays. Determination of drug potency using iso- supervision of thesis adviser and committee off site, and is to reg i s t e re d lated tissue preparations. Determination of the affinity of an antagonist for when a major portion or res e a r ch will take place outside of the Unit- for an agonist at a receptor site. Evaluation of potencies of anesthetics, ed States and or United States provinces. analgesics, and anticonvulsant agents. Pre re q u i s i t e : Permission of thesis adviser. Co re q u i s i t e : BC P 401 Variable and repetitive credits, 1-12 per term, fall and spring terms Fall, 2 cred i t s BC P 40 4 Advanced Pharmacology Laboratory HBH 800 Full-time Summer Research The use of molecular modeling software for the understanding of struc - Full-time laboratory res e a r ch projects supervised by staff members. tu r e activity relationships. In vivo studies to demonstrate the pharma- Pre re q u i s i t e s : Permission of instructor and full-time graduate student cological mechanism of action of drugs acting on the autonomic, car- st a t u s . di o v a s c u l a r , and renal systems. Pharmacokinetic studies, using HPLC, 0 credit, summer term, staff to determine the rate of absorption, distribution, and excretion of ther- apeutic agents. Radio- and enzyme-immunoassays for the detection of HM 80 0 Clinical Pharmacology ci r culating hormones. Cell culture techniques for drug determination This course is designed to provide fourth-year medical students with and evaluation. Pre r equisites: BC P 401 and 403 practical information about therapeutics. Using a case-oriented Co re q u i s i t e : B C P4 0 2 ap p r oach, students are taught to develop a systematic approach to spe- Spring, 2 cred i t s cific, more common, therapeutic interventions. Basic principles of clini- cal pharmacology are emphasized with the goal of having students BC P 40 6 Pharmacology Colloquium understand drug interactions, dosing schedules, alterations needed in Re s e a r ch Seminars in Pharmacology and toxicology presented by facul- tr eating the elderly and patients with renal or hepatic dysfunction. ty and distinguished scientists from academic and industrial institu- Restricted to fourth-year students only. tions. Aone-hour Journal Club/Discussion Session precedes seminar to Pre re q u i s i t e : Permission of Instruc t o r review a ref e r ence paper relevant to the res e a r ch concepts to be pre- Drs. Grollman, and Steigbigel sented. Students are expected to develop an understanding of the sci- entific principles given in the colloquium. Speakers meet with the stu- dents after the seminar to discuss res e a r ch concepts and to answer For the undergraduate pharmacology program offerings in the College questions. May be rep e a t e d . of Arts and Sciences, please refer to the Undergraduate Bulletin. Pre re q u i s i t e s : BIO 202 and 203; CHE 322; g.p.a. of 3.0 req u i r ed in theses courses and their prer equisites; permission of department BCP 394 Environmental Toxicology and Public Health Spring, 2 cred i t s . Principles of toxicology will be presented and problems associated with major classes of toxic chemicals to human and environmental health BCP 475 Undergraduate Teaching Practicum in examined. Case studies dealing with current waste management issues Ph a r m a c o l o g y will also be discussed. Students will be req u i r ed to integrate basic infor- Pre re q u i s i t e s : Pharmacology Major; U-4 standing; s/u grading; permis- mation on the chemistry and biology of toxic compounds and apply sion of department this knowledge in a multidisciplinary context. 3 credits - S / U grading Pre r equisite: BIO 201 (or the discontinued BIO 151) CHEM 131 (or equiv- alent) or permission. BCP 487 Research in Pharmacology This course fulfills an upperdivision DEC req u i r ement in Category H. Completion of an individual student res e a r ch project under the super-

139 vision of a faculty member. Previously acquired laboratory course tech- Assistant prof e s s o r s : George Baldo, Roger Cameron, John Flana- niques and new proc e d u r es are utilized. Experimental results must be gan, Mary Frame, Junyuan Gao, Scott Lowe, Nicholas Nassar, submitted to the department for grade evaluation in the format of a Srinivas Pentyala, S.V. Ramanan, Mario Rebecchi, Michael res e a r ch report. Not for credit in addition to HBH 396, 398, and 399. Sampson, Ramakrishna Seethala, Kulandiaappan Varadaraj, May be rep e a t e d . Pre re q u i s i t e s : BIO 202 and 203 ( or the discontinued BIO 152); CHE 322 Thomas White and 327; a G.P.A. of 3.0 in these courses and their prer equisites; permis- sion of instructor and department The department of physiology and biophysics offers a prog r a m Fall and spring, 0 to 3 cred i t s of study leading to the Doctor of Philosophy degree. Physiolo- gy and biophysics has responsibility for teaching in the schools BCP 488 In t e r n s h i p of the Health Sciences Center and for graduate studies. Molec- Re s e a r ch participation in off-campus laboratories, the pharmaceutical ul a r , cellular, organ physiology and biophysics are the principle i n d u s t r y, and other academic and public agencies. Students are ar eas of teaching and res e a r ch specialization. The department’s req u i r ed to submit to the department a proposal at the time of reg i s t r a - focus of interest is in three general area s : tion and a report at the end of the semester. Satisfactory/Unsatisfacto- ry grading only. 1) Hormonal regulation of cell function and metabolism, Pre re q u i s i t e s : BIO 361; CHE 322; G.P.A. of 3.0 or higher in these courses with special emphasis on intercellular and intracellular and their prer equisites; permission of department and Office of Under- signalling mechanisms graduate Studies 2) Biophysical studies of membranes and prot e i n s Su m m e r , 3 to 6 cred i t s 3) Cellular physiology and electrop h y s i o l o g y 4) Pr econditioning and arrhythmia prev e n t i o n Studies are conducted at the molecular, sub-cellular, Department of Physical Medicine and Rehabilitation ce l l u l a r , organ and intact animal levels. Acting Chair: Jennifer Semel-Carlos Concepcion (St. Charles) Co u r s e s

Associate Professor: Lyn Weiss (NUMC) HB Y 35 0 Ph y s i o l o g y The normal functioning of human tissues and organs and their reg u l a - Assistant prof e s s o r s : Ernesto S. Capulong, Magda Fahmy (VA), tion and integration by the nervous and endocrine systems. Empha- Walter Gaudino, Harvey Goldberg, Adam Isaacson, Dae-Song sizes physiological control systems and the preservation of the constan- Kim, Thomnas Pobre (NUMC), Ajendra Sohal, Susan Stickev- cy of the internal environment. ers (VA), Jay Weiss Pre r equisites: College courses in biology and chemistry and some back- gr ound in physical sciences or permission of the instruc t o r . Primarily intended for students in the SHTM Program and Pharmacology majors. In s t r u c t o r s : S. Pani Akuthota, Sandra Barrett 4 credits, fall term, Mod G, Dr. Clausen and staff

Attendings: Adam Carter, Alan Ng, Wing NG, Yu-Jen Lai HB Y 393, 394 Special Topics from Physiology and Biophysics Literature The department of Physical Medicine and Rehabilitation pro- Tutorial readings in physiology and biophysics with periodic confer- vides an educational experience for fourth year students who ences, reports and examinations arranged with the instruc t o r . Open to ar e interested in the specialty. Students will gain exposure to the junior and senior students. field of rehabilitation medicine in a variety of settings including Pre r equisite: Permission of instruc t o r . Variable credits, 1-2 each, fall and spring terms, staff inpatient, outpatient and electrom y o g r a p h y . Students will learn the physiatric approach to patient care, and the roles of the var- HB Y 398, 399 Research Project in Physiology and Biophysics ious rehabilitation team members. The elective is based at St. An independent re s e a rch project under faculty supervision, that Charles Hospital Rehabilitation Center. emphasizes the principles of experimental design, data collection, eval- Students may contact Craig H. Rosenberg, MD, prog r a m uation of findings, and reporting of results. Project report req u i r ed. May Di r ector of the University Physical Medicine and Rehabilitation be rep e a t e d . Residency training program, at (631) 474-6879 or at Pre re q u i s i t e s : Laboratory experience and permission of the supervising Cr a i g . R o s e n b e rg @ s t c h a r l e s . o r g in s t ru c t o r . 2-4 credits per term, fall and spring terms, staff

HB Y 50 1 Ph y s i o l o g y In t r oduces normal function of human tissues and organs and their reg - Department of Phys i o l o g y and Biophys i c s ulation by nervous and endocrine systems. Emphasizes the orga n i z a - tion and function of physiological control systems and the maintenance Ch a i r : Peter R. Brink of a constant internal environment. Enrollment restricted to fully matriculated graduate students, with permission of instruc t o r . Pro f e s s o r s : Nada Abumrad, William B. Benjamin, Peter R. Brink, 4 credits, fall term, staff John B. Cabot, Carol Carter, Ira S. Cohen, Norman H. Edelman, Emelia Entcheva, Jack Fajer, Michael Goligorsky, Roger A. HB Y 50 2 Medical Physiology A graduate level approach to the physiology of the organ systems is Johnson, Irvin B. Krukenkamp, Richard T. Mathias, Stuart G.A. ad d r essed in a lecture format with the emphasis on prob l e m - s o l v i n g . McLaughlin, Lorne Mendell, Leon C. Moore, Michael R. Rosen, Relevant clinical correlations are addressed at the end of each block John Sacks, Sami Said, Gerald Smaldone, Steven O. Smith, insofar as they illustrate how symptoms and signs of disease res u l t George Stephano, John C. Sutherland, William VanderKloot fr om disorde r ed physiology. Organ Systems addresses the struc t u r e (Emeritus) and function of the cardi o v a s c u l a r , res p i r a t o r y , renal, gastroi n t e s t i n a l , endocrine, skeletal, rep r oductive and integumenary systems. Associate prof e s s o r s : Ki H. Chon, Chris Clausen, James P. Dilger, Pre re q u i s i t e : permission of instruc t o r Raafat El- Maghrabi, Yaacov Hod, James B. Konopki, David 4 credits, spring term, ABCF grading, staff McKinnon, W. Todd Miller, Suzanne Scarlata, Irene C. HB Y 51 1 Introduction to Biophysical Chemistry Solomon, Ilan Spector, Hsien-Yu Wang In t r oduces the chemical principles and techniques needed for the study

140 of biological macromolecules. Topics covered include solution chem- P re re q u i s i t e s : Systems Physiology, Biochemistry, an permission of is t r y , chemical thermodynamics, binding and dissociation equilibria, in s t ru c t o r denaturation phenomena, spectro s c o p y, and hydrodynamics. This 3 credits, fall term course is intended to prep a r e non-chemistry majors for more advanced work in biophysics. Crosslisted with HBM 511. HB Y 57 0 Student Journal Club Pre re q u i s i t e : Permission of instruc t o r . Graduate student presentation on a selected topic with faculty consul- 2 credits, fall term ta t i o n . Pre re q u i s i t e : Limited to students of the Physiology and Biophysics pro- HB Y 53 0 Cellular Physiology and Biophysics gr a m . Cellular struc t u r e and function. Topics include ion channels, excitabili- 1 credit each semester, repetitive, fall and spring term ty , transport, energetics and metabolism, contraction, secretion, and communication within and between cells. Emphasizes quantitative HB Y 59 0 Special Topics in Physiology and Biophysics analysis of cellular proc e s s e s . Students seminars on topics to be arranged through consultation with Pre re q u i s i t e : Un d e r graduate physics, physical chemistry, biology, calcu- faculty members. lus, or permission of instruc t o r . Pre re q u i s i t e : Permission of instruc t o r . 4 credits, fall term Variable and repetitive credits, 1-2 per term, fall and spring terms, staff

HB Y 53 1 Medical Physiology HB Y 59 1 Physiology and Biophysics Research A graduate-level introduction to the physiology of the organ systems Original investigation under the supervision of a staff member. with ultrastructural correlations. Ultrastructural correlations are Pre re q u i s i t e : Permission of instruc t o r . demonstrated in a laboratory setting using histological preparations in Variable and repetitive credits, 1-12 per term, fall and spring terms, staff conjunction with electron micrographs illustrating the relevant ultra- st ru c t u r e needed to understand the normal functioning of tissues and HB Y 69 0 Seminar in Physiology and Biophysics or gans. The physiology of the major organ systems is addressed in a lec- Seminars and discussions on major topics in physiology and biophysics tu r e format with the emphasis on problem solving. Relevant clinical by students, staff and visiting scientists. co r r elations are addressed at the end of each block in so far as they illus- Pre re q u i s i t e : Permission of thesis adviser trate how symptoms and signs of disease result from disorde r ed phys- Variable and repetitive credits, 1 per term, fall and spring terms, staff io l o g y . Organ Systems addresses the struc t u r e and function of the car- di o v a s c u l a r , res p i r a t o r y , renal, gastrointestinal, endocrine, skeletal, HB Y 69 5 Practicum in Teaching in Physiology and rep r oductive, and integumenary systems. Bi o p h y s i c s Pre re q u i s i t e s : Admission to medical or dental school and permission of Practical experience and instruction in the teaching of physiology and in s t ru c t o r . biophysics carried out under faculty orientation and supervision. 8 credits, spring modules, Dr. Cameron Pre re q u i s i t e : Permission of instruc t o r . Variable and repetitive credits, 1 per term, fall and spring terms, staff HB Y 55 2 Physiology of Excitable Membranes Covers the resting potential, the basis of the action potential, linear HBY 800 Full-time Summer Research cable properties and synaptic transmission. Studies squid axon, the Full-time laboratory res e a r ch projects supervised by staff members. ne u r omuscular junction and the cardiac Purkinje fiber model systems. Pre r equisite: Permission of instructor and full- time graduate status. Pre re q u i s i t e : Physics, physical chemistry and calculus. 0 credit, summer term, staff 3 credits, spring term, even years, Drs. Cohen and Mathias Department of Preven t i ve Medicine HB Y 55 3 Signal Tra n s d u c t i o n The course will emphasize fundamental concepts in signal transduction Ch a i r : John S. Kovach (e.g. membrane-protein and prot e i n - p r otein interactions, amplification of signals), and individual lectures will apply these concepts at each stage of cell signalling from the cell surface to the nucleus, where signal Distinguished Prof e s s o r : M. Cristina Leske transduction leads to specific gene expres s i o n . 3 credits, spring term, odd years, ABCF grading, staff Distinguished Service Professor: Dorothy S. Lane

HB Y 55 4 Principles of Neuroscience P ro f e s s o r s : Evelyn Bromet, John Coulehan, Wajdy Hailoo, The aim of this course is to highlight and create an understanding as to David Harris, Steven Jonas, Dorothy S. Lane, M. Cristina how the human nervous system operates. Leske, Nancy R. Mendell, Andre O. Varma (Emeritus), Peter C. Pre re q u i s i t e : Un d e r graduate biochemistry, biology and chemistry. Per- Williams mission of instruc t o r . 2 credit, fall term Associate prof e s s o r s : Clare Bradley, Steven Finch, Roger Grim- HBY 561 Statistical Analysis of Physiological Data son, Anselm J. Hennis, Mary Hibberd, Leslie Hyman, Eugene J. 1 credit, fall term Mitacek, Elinor Schoenfeld HBY 562 Model-based Analysis of Physiological Data 1 credit, fall term Assistant prof e s s o r s : Catherine Belling, Mary Cavanagh, John HBY 563 Measurement and Analysis in Physiological Research Chen, David G. Graham, Iris Granek, Abby Greenberg, Eugene 1 credit, spring term Komaroff, Martin Mayer, Sara L. Mendesohn, Catherine Messi- These courses are designed to introduce the principles of experimental na, Barbara G. Nemesure, Daniel New, Michael L. Rainey, design relevant to modern physiological research. Emphasis will be Henry Thode, Suh-Yuh Wu placed on data acquisition, signal processing and statistical analyses associated with the basic experimental approaches currently used in physiological research. Lecturers: Oliver C. Schepers, Eugene Theissen, Mahfouz H. Prerequisites: Introductory statistics and permission of instructor. Zaki 1 credit each, fall and spring terms, ABCF grading In s t r u c t o r s : Leo DeBobes, Lynette Dias, Brian Harper, John HB Y 55 7 Advanced Physiology Marchese, Linda Mermelstein, Shibani Ray-Mazumder, Hector This course is designed to introduce students to integrative approa c h e s Sepulveda, Anthony Shih, Bette Taylor, Lucille Weinstein in biomedical res e a r ch. Emphasis will be placed on the primary physi- ological concepts of control, communication, signal processing, metab- The department has three divisions-the division of epidemiolo- olism and rep l i c a t i o n .

141 gy , which also includes biostatistics; the division of occupation- HM C 361-G Literature and Medicine al and environmental medicine; and the division of medicine in Ex p l o r es major themes of medical care and illness as presented in works so c i e t y , which includes the Institute of Medicine in Contempo- of poetry, prose, and drama. Includes personal and ethical dilemmas rary Society. co n f r onted by doctors; special characteristics and discourse of the med- ical setting; the experience of being ill; philosophical, social, and spiri- The department applies these skills and activities toward tual dimensions of the clinical encounter; and the search for meanings th r ee major goals: in medical events. 1. teaching of the discipline Pre re q u i s i t e : One course in literature or HMC/SOC 200 2. conduct of res e a r ch therei n 3 credits, Dr. Coulehan 3. clinical practice of occupational and preventive me d i c i n e HMC 486 Practicum in Health and Society A major emphasis of the division of epidemiology is on the Observation and seminar of readings in humanities and social sciences. epidemiology of eye diseases, cancer, and Lyme disease; a Primarily for upper-division students, especially those completing a major emphasis for the division of occupational and environ - minor in Health and Society. Pre re q u i s i t e : Permission of instruc t o r mental medicine is diagnosis, treatment and prevention of 3 credits, Dr. Wil l i a m s work and environmental illnesses. Disciplines also included in the department are healthcare delivery systems analysis and Department of Psychi a t r y and Behavi o r al Science the study of ethical and legal issues in healthcare. In its clinical aspects, the department involves the planning, operating, and Chair: Mark J. Sedler evaluation of disease prevention, healthcare and maintenance pr ograms, employee health services, and the practice of applied Pro f e s s o r s : Sheila Blume, Evelyn Bromet, Gabrielle A. Carlson, epidemiology and biostatistics and clinical ethics. Thomas Craig, Max Fink (Emeritus), Kenneth Gadow, Marvin The department has teaching responsibilities at each stage of R. Goldfried, Dimitry Goldgaber, Fritz Henn, Robert J. Hitze- medical education. The department offers a req u i r ed Introd u c - mann, Thomas Horvath, Daniel Klein, Jan Loney (Emeritus), tion to Preventive Medicine course to medical students in the Alan Miller, Lawrence Morin, Charles Rich, Nisson Schechter, first year. This course presents basic epidemiological and statis- Arthur Stone, William J. Turner (Emeritus), Nora Vol k o w , Rex tical concepts used to study health and disease in populations Wan g and describes their application in primary, secondary and ter- tiary prevention. The department also offers a coordi n a t e d , Associate prof e s s o r s : Linda Chang, Steven Cole, Judith Crow e l l , fo u r -year course titled Medicine in Contemporary Society. This Laura Fochtmann, A n d rew Francis, Gregory Ficchione, series of courses deals with ethics, law, economics, history and Kr i s h n a r eddy Gujavarty, Gila Hertz, Marta Maczaj, David Mey- other social aspects of medicine. Teaching of social issues in erh o f f, George Nicklin, Sanford Oxenhorn, Harold Pass, Joseph medicine continues into the clinical and postgraduate years. A Schwartz, Michael Schwartz, Mark J. Sedler, Joyce Sprafkin, Jef- br oad range of electives–from clinical experience in a neighbor- fr ey Sverd, Vasantkumar Tanna, James N. Wei s b e r g hood health center to basic res e a r ch in epidemiology, injury co n t r ol, computing, occupational medicine and health services Assistant prof e s s o r s : Ashraf Abaza, Susan Abbott, Thomas Aro n - systems–is offe r ed in the fourth year. son, Varsenik Arvanian, Murty Ayyala, Aa r on Balasny, Char- In addition to teaching medical students, the department lene Baldwin, Joseph Blader, Lory Bright-Long, Darla Brob e rg , of fers academic and field training for residents in prev e n t i v e Joan Broderick, Paul Brod y , Christopher Burke, Patrick Caron e , medicine. Residents can take one-third of the course req u i r e- Robert Castroll, Arvind Chopra, Shelly Cohen, Eduardo Con- ments for the Master’s in Public Health degree offe r ed by stantino, Frank Dowling, Shelley Epstein, June Feldman, Erik Columbia University, within the department of prev e n t i v e Fink, Jennifer Flynn-Campbell, Fred Friedberg, Jerry Friedman, medicine at Stony Brook. Residents can also complete the mas- Veena Garyali, Yakov Greenstein, Zinoviy Gutkovich, Peter te r ’s degree req u i r ement in a joint program offe r ed by the Halperin, Jeffr ey Hammerman, Jay Harris, Angela Hegarty, department and the W. Ave r ell Harriman School for Manage- Seth Horowitz, Kamil Jaghab, Marsha Tan e n b e r g-Karant, Joel ment and Policy. King, Charles Korrol, Beatrice Kovasznay, Ganesan Krish- The department offers several elective and crosslisted courses n a m o o r t h y, Richard Kru g l e y, Kerstin Kupfermann, Daniel for other health professional and pre- p r ofessional students. Legrange, Tsu Teng Loo, John Luke, Gerald Lutzer, Deborah Ma j e r ovitz, Douglas Marcus, Richard Mattison, Chang Min, Co u r s e s Lilianne Mujica-Parodi, Jacob Ninan, Tadao Ogura, Donna Osikowicz, William Packard, Elias Pasol, Selwyn Pere i r a , HM C 20 0 Medicine and Society Steven Pre n z l a u e r, Horacio Preval, Wolfgang Quitschke, Examines traditional concerns of the humanities and social sciences as they interface with healthcare and its delivery. Clinical cases are pre- Matthew Romanelli, Bruce Rosen, Joan Rubinstein, E. Vic t o r i a sented by practicing physicians or other health professionals to intro- R u n d b e rg-Rivera, Magery Satish, David Schlager, Mark duce such topics as confidentiality, experimentation, death and dying, Sc h o e n b e r g, Irving Shelsky, Sashi Shukla, Michael W. Slome, allocation of scarce res o u r ces, etc. Focus on the social, historical, ethical, Ed w a r d Sodaro, Alan Steinberg, Robert Vincent, Sheldon Wei n - and humanistic import of the cases. traub, Deborah Wei s b r ot, James Wei s s b u r g, R. Michael Woz n i c k i 3 credits, Dr. Williams and staff In s t r u c t o r s : Shashi Berdia, Dominick Candido, Antoinette Fos- HM C 33 1 Legal and Ethical Issues in Health Care te r , Rita Gal-Vetrano, Marlene Gralnick, Michael Gree n b e rg , In t r oduces some of the major ethical and legal doctrines that affe c t Kevin Kelly, Maureen Largan, Judith Lutzer, Carrie-Ann Miller, he a l t h c a r e professionals. Ad d r esses specific problem situations, includ- ing the right to refuse medical, mental and social care; the right to life Alexander G. Oei, Etalee Pass, Mona Ramjas, Chitra Shenoy, and its limits (e.g., suicide, euthanasia, abortion); the right to rec e i v e Robert Southard, Linda Win t e r ca r e access to and evaluation of healthcare delivery. Emphasizes sensi- tizing students to legal and ethical issues. The Department of Psychiatry and Behavioral Science prov i d e s 3 credits, Dr. Wil l i a m s a complete range of instruction from beginning medical educa- tion through post-residency fellowships. Members of the department are involved in teaching in psychology, neurob i o l -

142 og y , and pharmacology, as well as psychiatry. Department of Radiation Oncology The Department is organized into three divisions: Adult Psy- ch i a t r y , Child Psychiatry and Developmental Disabilities. Ser- Ch a i r : Allen G. Meek vices in these divisions may be provided at Stony Brook Uni- versity Hospital, at Northport Veterans Af fairs Medical Center, Pro f e s s o r : Allen G. Meek, Lawrence E. Reinstein and Eastern Long Island Hospital. University Hospital services pr ovide 30 adult care beds, adult dayhospital facilities, 10 chil- Associate prof e s s o r s : Wyman A. Bethune, Tae L. Park dr en’s beds, a comprehensive psychiatric emergency prog r a m , a consultation-liaison service and out patient clinics for adults Assistant prof e s s o r s : Leon Forman, Jonathon Hass, Alan Katz, Bong S. and children. Northport Veterans Af fairs Medical Center pro- Kim, Magdy S. Shady, Edward S. Valentine, Tamara E. Weiss vides a 50-bed acute in-patient service and a 50-bed chronic care service. Eastern Long Island Hospital provides an 18-bed and In s t r u c t o r s : Edward Glenn, Herman Treitel adult inpatient service. The faculty within the department are dedicated to res e a rc h The Department of Radiation Oncology, which functions at the related to an understanding of psychiatric disorders, ranging Health Sciences Center at Stony Brook and at a satellite facility fr om basic neurobiological res e a r ch to applied clinical studies. at Brookhaven National Laboratory, is organized to develop Th r ough joint appointments with other departments many and teach the disciplines of radiation physics, radiation biology faculty supervise and support graduate and post-doctoral stu- and therapeutic radiology as applied to the treatment of malig- dents in related disciplines. nancies and selected benign disorders. Active basic and clinical Medical Student Education res e a r ch programs operate in conjunction with other medical school departments and the Brookhaven National Laboratory. The department is committed to an interdisciplinary approa c h Un d e r graduate and graduate as well as medical students inter- to mental health throughout its curricular activities. Within the ested in res e a r ch collaboration or the clinical oncology of solid curriculum of the medical school, the department offe r s tumors are encouraged to apply for elective rot a t i o n s . • Active involvement in teaching year 1 and year 2 medical students in the Introduction to Human Co u r s e s Behavior course • Active involvement in the year 2 Neuros c i e n c e / P s y - HB I 398/399 Research Projects in Radiation Oncology Medical chopathology course Ph y s i c s • Atwo-week req u i r ed clinical clerkship in Behavioral An independent res e a r ch project under faculty supervision. Empha- Medicine (fourth year) sizes the principles of experimental dessign, data collection, evaluation • A fo u r -week req u i r ed clinical clerkship in Clinical of findings and reporting of results. Project report req u i r ed. May be Psychiatry (third year) repeated. • A psychiatry sub-internship available to students in Pre re q u i s i t e : Laboratory experience and permission of the supervising their third and fourth years on an elective basis. This in s t r uctor and URECAco o rd i n a t o r . Completion of 57 credits in the Col- track is designed for students who are interested in a lege of Arts and Sciences. 2-4 credits, fall and spring terms, staff ca r eer in psychiatry • Electives within the department include res e a r ch HB I 59 9 Graduate Research in Radiation Oncology and clinical opportunities in a wide variety of Medical Physics se t t i n g s Original res e a r ch projects under the faculty supervision in areas of medical physics relating to radiation oncology and computer science. Re s i d e n c y Prog ra m Pre re q u i s i t e s : Bachelors of Science in Physical Science or Engineering; The Department of Psychiatry and Behavioral Science offers a permission of instruc t o r . fo u r -year residency program in psychiatry with the first year 1-8 credits, fall and spring terms, staff designed as a categorical postgraduate-1 “mixed” clinical expe- rience. The residency program provides a broad variety of situ- Department of Radiology ations, subjects and settings from which residents and students may select their learning experiences. The program goal is to Ch a i r : Donald P. Harrington train a physician who specializes in the treatment and under- standing of diseases and abnormalities that manifest them- Pro f e s s o r s : Ha r old L. Atkins, Jack S. Deitch, Sidney Glanz, Bur- selves in behavioral change. Such a physician should be well ton Gold, Donald P. Harrington, Gerald Irwin, Arie Kaufman, gr ounded in diagnostics, psychopharmacological interventions Morton A. Meyers, Zvi H. Oster, Robert Peyster, Mathew D. and behavioral management techniques. The training prog r a m Rifkin, Stephen Shapiro, Prantika Som, Charles Springer, pays particular attention to the neurobiological foundations of Su r esh Srivastava ps y c h i a t r y , while at the same time providing training in psy- chotherapeutics and other skills necessary to the general prac- Associate prof e s s o r s : Roger S. Baim, Rashmikant Baxi, Harol d tice of psychiatry. The opportunities for res e a r ch are large and Chiat, Paul Fisher, John Ferretti, Gene Gindi, Jerome Liang, va r i e d . James Manzione, Paul Moh, Anita Price, Donald Price, Fel l o wship Trai n i n g Clemente T. Roque, Thomas Smith, Gene J. Wang, William G. Wol f f The Department offers several fellowships including clinical fellowships in child psychiatry, consult-liaison psychiatry, Sleep Assistant prof e s s o r s : Robert Blake, Terry Button, Cora Cabahug, Di s o r der and Geriatric Psychiatry. The child psychiatry fellow- Paul Cayea, Bruce Chernofsky, Jeane Choi, Avraham F. Dilman- ship is a complete two-year accredited program leading to ian, Ivy A. Engel, Heywood Y. Epstein, Kathleen Finzel, Seng- bo a r d eligibility in child psychiatry. hau Fong, Arthur Frua f f, Susana Fuchs, Karen Gadol, Brad Gluck, Lori Goffn e r , Allan G. Goldman, Matthew T. Higgins, Robert J. Hochstim, Man Hon, Wei Huang, Marga r et Johnstone,

143 Ca r ol E. Kaplan, William Kainzbaur, Douglas Katz, Hsin Min sions, each with its own chief. These sections include general, Kuan, Ira J. Langer, Steven Lev, Haifang Li, Richard Losada, ca r diothoracic, pediatric, plastic, transplantation, otolaryngolo- Ruimei Ma, Darius Melisaratos, Leslie Miller, Klaus Mueller, gy , oncology, trauma and vascular surge r y . Ge o r ge Newman, Orlando Ortiz, Roxanne Palermo, David The department has the following res p o n s i b i l i t i e s : Panasci, Harold Parnes, Mozaffer Partowmah, Eric Perlmutter, 1 )p rovision of consultations and operative surgery for Erica Posniak, Joel Reiter, Nand K. Relan, Patricia Roche, pa t i e n t s Le o n a r d M. Rosenstein, Sandra Russo, Raymond L. Saperstein, 2) pr ovision of surgical aspects of diagnosis in the core Br uce I. Saxe, Sol Spector, Sharon Tay l o r , G. Lucy van de Veg t e , curriculum in the pre-clinical years Natarajan Venkataramanan, Patrice Vorwerk, Nandita Wad - 3) supervision of a residency program in general hwa, Barbara Waj s b r ot-Kandel, Mark Wax, David Wel t m a n , su r gery (five-year duration) Paul Zamora, Wei Zhao 4 )o rganization and supervision of clinical clerkships 5 )o ffering of electives in the final year In s t r u c t o r s : Susan Aiello, Dinko Franceschi 6) pr eparation of individuals who choose the specific branches of surge r y Ra d i o l o g y , including the multiple imaging modalities of con- 7) investigation of relevant problems of surgical ventional diagnostic radiology, magnetic resonance imaging, sc i e n c e s . computed tomography, ultrasonography, and nuclear medi- cine, is not only a clinical discipline in itself, but is supportive in Department of Urol o g y the essential applications of several of the basic sciences and most of the other clinical specialties. Ch a i r : Wayne C. Wal t z e r Radiographic Anatomy is taught as part of the first-year cur- riculum to complement the dissectional displays of reg i o n a l Pro f e s s o r s : Zelik I. Frischer, Sardar Ali Khan, Wayne C. Waltzer, human anatomy, and radiology is further useful within Intro- Robert J. Wasnick duction to Clinical Medicine. Diagnostic imaging plays an important role in the core curriculum of the second year, in the Associate prof e s s o r s : Yefim Sheynkin knowledge of pathophysiology of the various systems. A detailed course in Clinical Radiology is presented throu g h o u t Assistant prof e s s o r s : Howard L. Adler, Jamil U. Rehman, David the third year, and a selective course in Diagnostic Imaging is A. Schulsinger given in the fourth year. In addition, radiology provides support throughout the clini- In s t r u c t o r s : Maryanne Frank, Yvonne Kwok, Jeanne Martin, cal curriculum in the diagnosis and management of patients. Kathleen Kelly-Lyons, Ann Klassert, An increasing choice of electives is offe r ed in the radiological su b s p e c i a l t i e s . The department provides care for a wide variety of both gener- al and tertiary urological problems. Subspecialty services Re s i d e n c y Prog ra m include cryoablation of the prostate, female urol o g y , human The Department of Radiology offers a four-year residency in papilloma virus disease, infertility and micros u rg e r y , kidney diagnostic radiology. The residency includes experience in all stone disease and lithotripsy, laser surge r y , neuro- u ro l o g y , pedi- aspects of general radiology, as well as, ultrasonography, com- atric urol o g y , rec o n s t r uctive urol o g y , sexual dysfunction, kid- puted tomography/neuror a d i o l o g y , nuclear medicine and spe- ney transplantation, and urological oncology. The faculty of the cial proc e d u r es. Emphasis is placed on clinical radiology and department of urology provide comprehensive general and ter- clinically oriented res e a r ch. Fellowships in Body Section Imag- tiary urological care. ing, including Computed Tom o g r a p h y , Ultrasonography and Magnetic Resonance Imaging, Neuror a d i o l o g y , Interventional Re s i d e n c y Prog ra m Ra d i o l o g y , and Nuclear Radiology are also offe re d . The department of urology offers an accredited four-year res i - dency that includes training in all aspects of urology in all the above disciplines. Department of Surgery Sc hool of Medicine Interdepartmental Courses Chair: John J. Ricotta HB I 398/399 Research Projects in Biomedical Sciences Pro f e s s o r s : Thomas Bilfinger, Peter Garlick, Arnold E. Katz, An independent res e a r ch project under faculty supervision. Empha- Irvin Krukenkamp, Cedric J. Priebe, Jr., Harry S. Soroff sizes the principles of experimental design, data collection, evaluation of findings and reporting of results. Project report req u i r ed. May be rep e a t e d . Associate prof e s s o r s : Martyn W. Burk, Collin E.M. Brathwaite, Pre re q u i s i t e : Laboratory experience and permission of the supervising Enrique Criado, Alexander Dagum, Martin Karpeh, Margaret in s t r uctor and of URECAco o rd i n a t o r . Students should have completed McNurlan, Eugene Mohan, Frank C. Seifert, Maisie Shindo, 57 credits in the College of Arts and Sciences. Eric Smouha, Joseph Sorrento 2-4 credits, fall and spring terms, staff

Assistant prof e s s o r s : Arif Ahmad, Balvantray Arora, Robert Bar- HB I 59 9 Graduate Research in Radiation Oncology raco, John S. Brebbia, Antonios Gasparis, Steven M. Katz, Medical Physics Thomas Lee, Allison McLarty, Louis T. Merriam, Denise C, Original res e a r ch projects under faculty supervision in areas of medical Monte, Brian J. O’Hea, David Rivadeneira, Ghassan Samara, physics relating to radiation oncology and computer science. Pre r equisites: Bachelor of Science in Physical Science or Engineering; Richard Scriven, Paul van Bemmelen, James Vosswinkel permission of instruc t o r 1-8 credits, fall and spring terms, staff In s t r u c t o r s : Vimala Sivaraman

The Department of Surgery is organized into a series of divi-

144 Department of Biomedical Engineering The graduate program relies on the core set of courses to pro- vide our biomedical engineering students with an overview of Ch a i r : Clinton T. Rubin the biophysical principles involved in cell, tissue, and orga n bi o l o g y . The prog r ession of the four PIBE core courses req u i re s Assistant to Chair: Partap Khalsa th r ee resident terms to complete. In addition to these four courses, a seminar series providing exposure to the breadth of Graduate Program Direc t o r : Partap Khalsa bioengineering res e a r ch and development activities both with- in the University as well as throughout the scientific/industrial Un d e r graduate Program Direc t o r : Danny Bluestein co m m u n i t y , is req u i r ed of all PIBE students through their first two years of study. Finally, each course has a component of Pro f e s s o r s : Christopher Berndt, Fu-Pen Chiang, Benjamin Chu, independent study to nurture the student’s abilities to pursue a Ri c h a r d Clark, Yuefan Deng, Peter Djuric, Joanna Fowler, Fred topic specialized interest . Grine, Donald P. Harrington, Benjamin Hsiao, Lawrence C. Hurst, Chris Jacobsen, Jolyon Jesty, Arie E. Kaufman, Janos Curriculum Requirem e n t s Kirz, Irvin Krukenkamp, Jerome Liang, Serge Luryi, Harol d Ma s t e r ’s Degree Curriculum: thirty graduate credits are req u i re d Metcalf, Miriam Rafailovich, Nathaniel Reichek, Clinton T. to earn the Master of Science or Master of engineering degree s Rubin, Edward Schlissel, Charles Springer in biomedical Engineering (BME). Thirteen credits must consist of the five core BME courses, and six credits from business, Associate Prof e s s o r s : Danny Bluestein, Ki Chon, Avraham Dil- Tec h n o l o g y , and Engineering Policy courses. The student has manian, Petar Djuric, Gene Gindi, Vera Gorfinkel, Michael Had- the option of earning the Master of Science degree in BME on ji a rg y r ou, Chris Jacobsen, Partap Khalsa,, Yi-Xian Qin, Jahangir either a thesis or non-thesis track. If non-thesis, the student Ra s t e g a r , John Reinitz, Lawrence E. Reinstein, Callum F. Ross, undertakes elective graduate coursework to complete the 30 Steven Skiena, Lincoln Stein, Peter Williams, Ilya Vakser cr edits. In the thesis option, the student must complete two res e a r ch rotations and at least 6 credits of thesis res e a r ch, and Assistant Prof e s s o r s : Janet Anderson, Terry Button, Wei l i a m submit and defend a written thesis. Agrade of B or better must Chen, Anil Dhundale, Emilia Entcheva, Mary Frame, John Gat- be attained in each of the core BME courses taken, and an over- le y , Rita Goldstein, Wei Huang, Stefan Judex, Kathryn Kolsky, all grade point average of 3.0 out of 4.0 must be maintained Lisa Miller, Michiko Miura, Klaus Mueller, An d r ew Neuwald, ov e r a l l . Yingtian Pan, Bill Rooney, David Schlyer, Robert Shorr, Helmut St re y , Lilianne Strey , Peter Thanos, Paul Vaska, Mark Wag s h u l , Doctoral Degree Curriculum: A minimum of fifteen graduate Yi Wang, Stanislaus Wong, Kenny Ye, Micahel Q. Zhang, Wei cr edits, beyond the Master’s in BME level, are req u i r ed for com- Zhao, Wei Zhu pletion of the Doctor of Philosophy degree in BME. There are no course req u i r ements per se, though certain courses may be The Program in Biomedical Engineering trains individuals with req u i r ed to fill any gaps in the student’s knowledge. Following ba c c a l a u r eate degrees in engineering, applied mathematics, completion of a qualifying exam, and independent basic and the sciences to provide them with the synthesis, design, res e a r ch program will be undertaken. One semester of teaching and analysis skills necessary to contribute effectively to the practicum must be satisfactorily performed. Completion of this advancement of science and technology in health and medical res e a r ch program will culminate in the submission and oral ca re . defense of a dissertation. The University req u i r ed at least two Graduate degree programs are offe r ed at the Master’s (MS) consecutive semesters of full-time graduate study. All req u i r e- and Doctoral (PhD) levels. These programs provide two distinct ments for the PhD must be completed within seven years after avenues of graduate study in biomedical engineering - the completing 24 credits of graduate study. doctoral level directed toward the student interested in a res e a r ch or academic caree r , and the master’s level for those pri- Certificate Curriculum: To obtain the Advanced Graduate Cer- marily interested in the application of biomedical engineering tificate in Biomedical engineering, students will be req u i r ed to concepts in the development of advanced technology in bio- complete the five core courses (BME 501, 502, 503, 504, and medical products and processes. A th i r d option is the Ad v a n c e d 505/506) and maintain a 3.0 to 4.0 grade point average. In addi- Graduate Certificate program that is specifically designed to tion, six credits of elective coursework selected from business, pr ovide graduate students and engineering professionals with te c h n o l o g y , and engineering policy courses ensure that the stu- the knowledge and skills necessary to transfer recent develop- dents attain a reasonable level of sophistication in the business ments in the basic sciences into commercially viable prod u c t s concepts which will provide the graduate with the ability and and processes. The department’s goal of actively promoting the confidence to succeed in the field of biomedical engineering. development of a creative, versatile biomedical engineer is accomplished by exposing the individual to the biology, engi- Undergraduate Biomedical Engineering Program neering, and business concepts critical to succeeding in the bio- To provide the permanent foundation on which to build a medical res e a r ch and development environ m e n t . ca r eer in biomedical engineering, an integrated, core set of bio- To provide the permanent foundation on which to build a medical engineering courses have been implemented. These ca r eer in biomedical engineering, an integrated core set of bio- pr ovide our biomedical engineering students with the underly- medical engineering courses have been implemented. These ing engineering principles req u i r ed to understand how biolog- pr ovide our biomedical engineering students with the underly- ical organisms are formed and how they respond to their envi- ing engineering principles req u i r ed to understand how biolog- ronment. As well, the students will attain a credible level of ical organisms are formed and how they respond to their envi- sophistication in their understanding of cell, tissue, and orga n ronment. Students will attain a credible level of sophistication- ph y s i o l o g y . The student is then able to complement this back- in their understanding of cell, tissue, and organ physiology. The gr ound with additional engineering courses either within BME, student is then able to complement this background with addi- or in the other disciplines of engineering. tional engineering courses either within the Program in biomed- The Department of Biomedical Engineering offers several ical engineering (PIBE), or in the other disciplines of engineering. pathways for undergraduate students to obtain an understand-

145 ing of Biomedical Engineering: Thr ee Credits - Fall semester. • Minor program for Arts and Sciences majors Course Outline: Part 1. Biological Building Blocks and the Dynamics of Living Systems • Biomedical Engineering Track for Life Sciences majors Water and ionic balance, small molecules/energy balance Non-linear • Bachelor of Science (B.S.) in Biomedical Engineering continuum, discrete, and stochastic processes. Part 2. Cell Struc t u r es and Self Assembly Proteins, lipids, cytoskeleton, Graduate Biomedical Engineering Program and intracellular organelles Colloids, long range forces, colloidal stabil- it y , adsorption from solution. The graduate program relies on the core set of courses to pro- Part 3. Cell Physiology and Adaptive Processes Genetic mechanisms, vide our biomedical engineering students with an overview of cell division, cell signaling, cell-cell contacts Cellular automata, Boolean the biophysical principles involved in cell, tissue, and orga n networks, complexity, non-linear time series analysis. bi o l o g y . The prog r ession of the four BME core courses req u i re s BME 502 Engineering Principles in Tissue and th r ee resident terms to complete. In addition to these four Organ Systems courses, a seminar series providing exposure to the breadth of Course Director - D. Bluestein Biomedical Engineering res e a r ch and development activities Course content is directed toward describing the macroscopic physical both within the University as well as throughout the scientif- interactions within tissues as an extension of the engineering concepts learned in BME-501, i.e. the consequence of self-organized aggregates of ic/industrial community, is re q u i red of all BME students cells and matrix macro-molecules functioning as non-equilibrium sys- th r ough their first two years of study. Finally, each course has a tems. Fuzzy logic theory, neural network theory and genetic algorithms component of independent study to nurture the student's abili- will be developed to provide insight into physiologic behavior ranging ties to pursue a topic of specialized interest. Certificates and f rom homeostasis to cognition, while providing a fundamental overview of tissue struc t u r e and function and organ physiology. de g r ees available through this program include the following: • Advanced Graduate Certificate in Biomedical Engineering Th r ee Credits - Spring semester. • Master of Science (M.S.) Course Outline: • Master of Philosophy (M.Phil) in Biomedical Engineering Part 1. Overview of Tissue Physiology (Struc t u r e and Function) Cell- cell & cell-matrix interactions, autocrine/paracrine effects, homeosta- • Doctor of Philosophy (Ph.D.) in Biomedical Engineering sis Control theory, fuzzy logic, fuzzy control Application of fuzzy con- tr ol to tissue adaptation in connective tissue, kidney, liver, heart. The First Yea r Part 2. Simple Networks in Living Tissue Nerve conduction, synaptic For MS and Certificate students, the first year of study includes transmission Neural networks, supervised and unsupervised learning. Part 3. Complex Networks Reflex arcs, locomotion, sensory systems co r e courses, electives, and attending the PIBE seminars. Stu- (visual, auditory, tactile) Multilayer networks, mapping issues, appli- dents in the MS res e a r ch track are req u i r ed to identify a cation of NN to central nervous system. res e a r ch advisor by the end of their first Spring semester in the Part 4. Evolution in Networked Systems Immune system physiology pr ogram. For doctoral students, the first year includes prep a r a - and pathology Neural-fuzzy nets, Genetic algorithms. tion for the qualifying examination, taking any classes as BME 503 Cell & Molecular Imaging di r ected by their Dissertation Defense Committee, and initia- Course Director - Emilia Entcheva tion of independent res e a r ch. Most Doctoral students will take This course will cover basics of optics, micros c o p y , spectroscopy and their qualifying examination within the first year. Some inter- fl u o r escence in the context of imaging at the cellular and molecular level. Recently developed advanced imaging techniques for prob i n g national students may be req u i r ed to take remedial English pr otein interactions and live cell functions will also be discussed. The courses, depending upon their mastery of the language. Stu- course is organized in 3 modules: dents who are being financially supported by teaching assist- • Optics and Spectroscopy (e.g., Properties of light, polarization, antships will assist designated faculty in instructing under- di f fraction, spectra). • Fundamentals of Fluorescence and Applications to Molecular and graduate students. Cellular Measurements (e.g., Jablonsky diagram, Stokes' shift, emission, excitation spectra, fluorescence anisotropy). The Second Year and Beyon d • Signal Processing, Image Analysis Techniques and Scientific In the second year, most students will finish any remaining core Visualization (e.g., temporal and spatial filters, 1D and 2D Fast Fourier transform, spectral analysis, cros s - c o r r elation). and elective courses. MS res e a r ch track students will have Theory will be complemented by extensive use of Matlab and its begun their re s e a rch projects under a faculty member’s super- Image Processing Too l b o x . vision. Once Ph.D. students have successfully passed their qualifying eamination, they have no further req u i re m e n t s Thr ee Credits - Fall Semester except the completion and defense of an original dissertation. BME 504 Biomaterials Science and Analysis To improve scientific communication skills, all students partici- Course Director- Partap Khalsa pate in the weekly programlaboratory seminars where faculty, Course content is directed toward providing an introductory trea t - postdocs, and graduate students present the latest res e a r ch fro ment of the engineering issues implicit in understanding living tissue interactions with processed materials. Emphasis on identifying and m their laboratories. These intimate, yet informal meetings eliminating surface contamination, corrosion, and optimizing material allow students to learn by watching and presenting res e a r ch in surface properties and compatibility. a friendly and critical environ m e n t . Th r ee Credits - Spring semester. Course Outline: • Applications - prostheses, coatings and adhesives, implants, Gr aduate Course Offering biosensors, drug delivery • Biocompatibility BME 501 Engineering Principles in Molecular and Cell • Biofilm contamination, bacteria, viruses, yeast, fungi Bi o l o g y • Immunity and inflammation Course Director – D. Bluestein • Metalo-biochemistry Course content is directed towards describing the microscopic physi- • Interface Considerations - surfaceenergy , adsorption, permeability cal interactions between cells and their environment as electro- • Surface contamination (inorganic and organic) mechano-chemical processes occurring at surfaces. This is provided in • El e c t r o-chemical interactions the context of basic molecular biology and cell physiology concepts. • Biomaterials and processing - metal alloys, polymeric, ceramic, Emphasis is placed on developing an understanding of the critical rol e rei n f o r ced materials, surface modified materials, structural prop e r t y of non-linear dynamics, physical chemistry of adsorption and res o r p - considerations tion processes, self assembly in cellular automata, and how complexi- • Tissue engineering - use of biology and biological substrates ty arises within simple physical systems. in biomaterials

146 BME 505 (Fall) & 506 (Spring) Principles and Practice in for minimally invasive biosensor readout. Experiments may include Biomedical Engineering fl u o r escence microscopy of multi-labeling of cellular components, opti- Course Directors - C. Rubin & Y-X. Qin cal coherence tomography of tissue microm o r p h o l o g y . In t r oduces first year graduate students to the basic and clinical res e a rc h at the cutting edge of biomedical engineering. The course has two key BME 532 Time Series Based Modeling of Biological Data components: the first is a seminar series presented by internationally Aunified mathematical/time series framework for modeling and min- renowned bioengineers. An interactive discussion of topic-specific sci- ing biological data. Applications range from cardi o - re s p i r a t o r y , ren a l entific literature precedes the formal presentation. The second compo- blood pres s u r e/flow and sequence (DNA, RNA,proteins) to gene nent of the course is teaming up with a physician, in rounds, the oper- ex p r ession data. Tools of data analysis include neural networks, time- ating theatre, clinics, etc., to get exposure to the real-life problems which invariant and time-varying spectral methods, fractal and nonlinear face the medical community. It is hoped that the mix of science and clin- dynamics techniques, hidden markov model, clustering analysis, and ic will move students towards determining how they can make contri- various system identification techniques. butions to health and society. BME 557 Computational Biology Two Credits - Fall and Spring semesters. This course focuses on current problems in computational biology and bioinformatics. Our emphasis will be algorithmic, on discovering BME 507 Fundamentals of Biomedical ap p r opriate combinatorial algorithm problems and the techniques to Engineering Management solve them. Primary topics will include DNA sequence assembly, Course Director - Rob Shorr, Ph.D., D.I.C., Director for Business DN A / p r otein sequence assembly, DNA/protein sequence comparison, De v e l o p m e n t hybridization array analysis, RNAand protein folding, and phylogenic This course exposes the engineering student to the responsibilities that tr ees. (cross-listed as CSE 549). focus on the management issues in biomedical engineering. Manage- BME 559 Biomolecular Modeling ment functions are explored and the students learn how to integrate This course addresses the basic principles of biomolecular modeling these functions with engineering responsibilities. and the algorithmical aspects of existing and emerging methodologies. Aspecial emphasis is on modeling of proteins and on structural aspects BME 508 Molecular and Cellular Biomechanics of bioinformatics. The course focuses on methodologies, which are Course Director: Stefan Judex practically applicable to real biomedical problems. The course is direc t - Course content revolves around the effects and interactions of mechan- ed to students interested in the development of modeling methods. ical forces at the cellular and molecular level. The topics will range from (c r oss-listed as AMS 691) describing the molecular and cellular basis of the adaptation of tissues to physical signals, to prescribing specific mechanical environments for BME 599 Biomedical Engineering Research im p r oved tissue engineering, to delineating relevant molecular, cellular, Re s e a r ch to be supervised by a faculty member of the Program in Bio- and biomechanical techniques, all the way to issues involved in the medical Engineering. Students must have permission of instructor and development and approval of diagnostics and therapeutics in molecu- en r oll in appropriate section. Faculty to be identified by the student. lar engineering. For a deeper understanding of the course material as well as to allow students to apply their newly gained knowledge, this BME 601 Cardiovascular Fluid Mechanics course will contain a module on the design and analysis of experiments The course will cover the application of fluid mechanics principles to (i.e., applied biostatistics) and incorporate practical exercises in both the analysis of blood flow in the cardiovascular system under normal laboratory (e.g., a real time PCR experiment) or simulated computer and pathological conditions. It will follow an historical time line by settings (e.g., modeling of cell behavior). beginning with the most basic models of arterial blood flow, and pro- ceed to the most advanced theories related to physiology and patholo- BME 517 Radiation Physics gy flow phenomena, including an examination of the most up to date Course Director: Terry Button res e a r ch in the area and the development of devices and implants. This graduate offering provides an initial physical background req u i re d for the study of the Medical Physics. Sources of ionizing radiation BME 602 Topics in Biomedical Applications of including radioactivity (natural and manmade) and x-ray prod u c i n g Neural Networks devices are studied as well as sources of non-ionizing radiations such as This is a project based course which includes weekly seminars dis- ra d i o f r equency and ultrasound. The physical aspects of these radiations cussing advanced topics in fuzzy logic and neural networks and their ar e characterized by their interaction with matter and methods for their applications, in biomedical devices. Applications include drug delivery, de t e c t i o n . diagnostics, management information handling. Students utilize simu- lation software to develop algorithms to deal successfully with training BME 518 Radiobiology data sets of their own choosing. Course Director – Terry Button The biological consequences of irradiation (ionizing, ultrasound, laser, BME 604 Finite Element Modeling in Biology RF etc.) will be examined. Interaction mechanisms will first be exam- and Medicine ined followed by examination of the of the radiation impact at the mol- Course Director - Y-X. Qin ecular and cellular level. The use of radiation for therapeutic gain will Both finite diffe r ence and FEM are applied to solve the equations of be considered. As well, models will be developed for risk estimates. in c o m p r essible and compressible fluid flow in porous media with Topics to be covered will include: target theory, biological res p o n s e , emphasis on flows in skeletal tissues, i.e., bone and cartilage. Steady- NSD and risk estimates. state, transient flow, permeability and surface boundary conditions are discussed. Practical and recent studies in the field are also discussed. BME 520 Lab Rotation I Pr ogramming using FORTRAN or C languages will be req u i r ed. The The first of two req u i r ed semester-long res e a r ch rotations in BME Fac- student is also introduced to commercially available software packages. ulty laboratories. Students learn and perform new res e a r ch skills with the aim of completing a res e a r ch project that would be suitable for pre- BME 605 Biomechanics of Tactile Sensory Systems sentation at a national BME res e a r ch conferen c e . Detailed study of the biomechanics of tactile neurophysiology for engi- neers entering the field of haptics and robotics manipulations. An a t o m y BME 521 Lab Rotation II and electrophysiology of transducer cells and neurons starting at the The second of two req u i r ed semester-long res e a r ch rotations in BME fingertips and extending to the somatosensory cortex. Characteristics of Faculty laboratories. Students learn and perform new res e a r ch skills the external stimulus and its peripheral transformation. Relations of with the aim of completing a res e a r ch project that would be suitable for these topics to perceptual and/or behavioral responses. pr esentation at a national BME res e a r ch conferen c e . BME 606 Drug Gene Delivery BME 531 Biosensing and Bioimaging Course Director - Weiliam Chen This graduate course will teach graduate students in biomedical engi- Applications of biodegradable and biocompatible polymers in the neering current techniques used biosensing and bioimaging with an design of drug and gene delivery systems for site-specific applications. emphasis in optical methodology. It will start with a brief introd u c t i o n A br oad overview on the origin and development of controlled rel e a s e to a simplified version of optics (ray optics, fiber optics, scattering & therapeutic devices will be provided. Existing and proven commerci a l absorption, fluorescence, lasers and optoelectronics), followed by an in- pr oducts will be examined. The second half of the course will be devot- depth discussion about fiber-optic sensors, advanced microscopy (con- ed to the use of DNAas a therapeutic entity and issues relevant to DNA focal and multi-photon excitation microscopy), NIR absorption and flu- delivery will be explored. An assessment of the most up-to-date DNA or escence spectros c o p y , optical coherence tomography, photo-acoustic delivery technologies will be presented. Students are req u i r ed to write imaging, and time-of-flight and frequency-modulation photon migra- a term paper on a drug or gene delivery topics of their choice. Students tion imaging. For cellular and molecular imaging, it will discuss the ar e also expected to give presentations on drug delivery and gene ther- principles of Q-dots, molecular beacons for bio labeling and bioMEMS apy related topics during the course.

147 BME 610 Magnetic Resonance Course Director – Mark Wag s h u l This course provides a comprehensive study of magnetic resonance and its applications in medical imaging. An introduction of NMR is fol- lowed with development of the hardw a r e and processing aspects req u i r ed for MR image formation. An overview of basic and advanced MR imaging techniques is provided. Each student will select a topic in MR imaging for presentation at the conclusion of the course.

BME 612 Biomedical Engineering Aspects for the Use of Radiation in Medicine This course provides a comprehensive study of the use of radiation in medicine. Physical aspects of the interaction of radiation with matter and for the radiation production are initially considered. The underly- ing principles of current radiation based medical imaging is considered next. Topics include radiography, fluoros c o p y , radionuclide imaging and computed tomography. The use of radiation for the treatment of malignancy is considered with the focus on req u i r ed technology. Final- ly advanced applications of radiation are considered with focus on imaging and treatment. Each student will select a topic examining the engineering or technical application of radiation in medicine for pre- sentation at the conclusion of the course.

BME 666 Advanced Cardiac Electrophysiology This course deals with the inherent electrical properties of cardiac tis- sue. It presents a comprehensive quantitative treatment of ion channels, transmembrane and intracellular ion fluxes and other bioelectricity- related events on the molecular and cellular level. The course will pre- sent a balanced experimental and theoretical overview of cardiac bio- el e c t r i c i t y . Ap p r oximately half of the course is dedicated to the rev i e w of state-of-the-art experimental measurement techniques and data analysis tools used in cardiac electrophysiology today. The other half of the course deals with modeling approaches in cardiac electrop h y s i o l o - gy , from the nano- to the mesoscale. Clinical importance of the dis- cussed phenomena is emphasized and the acquired knowledge is put into perspective.

BME 698 Practicum in Tea c h i n g Un d e r graduate teaching to be supervised by a faculty member of the Pr ogram in Biomedical Engineering. Course to be identified by the stu- dent and graduate studies direc t o r .

BME 699 Biomedical Engineering Dissertation Research Re s e a r ch to be supervised by a faculty member of the Program. Pre re q u i s i t e : Students must be advanced to candidacy (G5); permission of instructor and enroll in appropriate section.

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