Nihonbashi Honchomuromachi 2-3-11, 3-3-9, Nihonbashi Life IT ScienceBuilding Building 2th Floor, 10th Chuo-ku, Floor, Chuo-ku, 103 Tokyo-0022 103, Japan-0023, Japan Phone (within(within Japan):Japan): 03-3241-4911; 03-3241-4911; Phone Phone (outside (outside Japan): Japan): +81-3-3241-4911 +81-3-3241-4911, Fax Fax (within (within Japan): Japan): 03-3241-3757; 03-3241-3757; Fax (outsideFax (outside Japan): Japan): +81-3-3241-3757 +81-3-3241-3757 (Monday-Friday (Monday-Friday 9:00-17:00) 9:00-17:00) Website: Website: www.link-j.org www.link-j.org

Published: MAR. 1, 2021 Building Ecosystem to Create Innovation in Life Science

LINK-J (Life Science Innovation Network Japan) builds platforms centered in Nihonbashi for networking and Tokyo Nihonbashi and Osaka Doshomachi exchanging information with people around the world. We serve people involved in life science research and its industry in the broad sense including preventative, presymptomatic and health and longevity medicine such have been pharmaceutical districts for 400 years. as regenerative medicine, precision medicine, drug development, medical devices and healthcare IT. L INK-J is headquartered in Nihonbashi, Tokyo, the historic area of Tokyo where Japan’s leading By encouraging the activation and creation of an innovative life science industry in Japan and the world, we pharmaceutical companies have had headquarters for the past 400 years and where expertise in the life contribute to the larger vision of a society where we can live healthily and happily. science field comes together.

Nippon Chemiphar Bakuroyokoyama Sta. Nihonbashi is located in central Kanda Tokyo Nihonbashi Sta. Ono Tokyo, where information, Meet with key operators. Attend events & programs Kowa Kodemmacho Sta. Torii people and investors meet Ayumi Tosho Building Nihonbashi Honcho 3-Chome Building to aid product development of your concepts. Daiichi Snakyo from all over the world. Visitors MFPR Nihonbashi Honcho Building

Senju Kracie Wakamoto enjoy the urban environment

Nihonbashi Life Science Building2 Takeda which gives them access to Alfresa GLOBAL LIFESCIENCE HUB Ueno Building Novo Nordisk Nihonbashi many commercial and lodging Muromachi Nihonbashi Life Science Building Guide and Support Tower Teikoku Nihonbashi Mitsui Tower Astellas facilities. We create and LAUNCH Building Bank of Japan Fuso Network and Collaborate Head Office distribute information from Ningyocho Sta. Santen Zeria Chugai Nihonbashi, this historically Toray Nihonbashi Life Science Hub Fukushima Building and geographically unique Mitsukoshi-mae Mitsubishi Tanabe Sta. place. Kyoto Kissei

Biogen Japan

Take off COREDO 日本橋 Grow Shionogi Nihonbashi Sta. Pharmaceutical Companies Connect TOKYO AstraZeneca Come Together Station LINK-J Facilities Matching and pitching events for Acceleration funding procurement Nippon Shinyaku Kayabacho Sta. Many Japanese representative Kita-shinchi Sta. programs for and alliance building Osaka Doshomachi entrepreneurs and pharmaceutical companies have their Bayer Networking events Fukushima Sta. startups roots in Osaka Doshomachi. There for various subfields Toray are also many excellent life sciences Kyorin Oebashi Sta. within the life science GlaxoSmithKline Osaka City Hall Promoting field related to universities and research Naniwabashi Sta. collaboration between Astellas Yodoyabashi Sta. organizations in this area. Asahi Kasei Pharma members and Nippon Shinyaku Higobashi Shionogi Kitahama Sta. LINK-J further accelerates the real Sta. Ono various international Kissei Nihon organizations Teikoku exchange between people across Fuso Ayumi fields in this area where a variety of Takeda Nippon Zoki life sciences related businesses, such Torii Sumitomo Dainippon Merck KGaA, Darmstadt, Germany Mitsubishi Tanabe as pharmaceutical, medical equipment, Senju Lifescience HUB West Otsuka Nippon Chemiphar regenerative medicine, and health Kowa related service, are being developed Asuka Honmachi Sta. Sakaisuji Honmachi Sta. through the mutual cooperation between Awaza Sta. Nippon Kayaku Mochida industry, academia, and government.

Map of Japan Pharmaceutical Manufacturers Association member organizations and companies.

Hisamitsu

1 2 Large Symposiums

We organize symposiums with 300-500 attendees throughout the year. We invite leaders in the field to discuss wide-ranging issues related to regenerative medicine, AI, medical devices, genomes, cancer, etc. EVENTS & • Industry-Government-Academia Regenerative Medicine Symposium (2016 - 2021) • Possibilities of Genome: The Challenge to Create a New Industry (2018) PROGRAMS • Innovation in Cancer Medicine (2019) • Cell Therapy and Gene Therapy-Beyond Gene Analysis- (2020)

Networkings

We host evening networking events with our LINK-J Supporters, who are entrepreneurs and experienced professionals in the fields of research and development, management, law and finance. We also host and co-host many global-scale events and receptions with international universities and corporations such as UC San LINK-J creates networking and collaboration Diego and many European and North American organizations. opportunities (Steps 1 & 2) and guiding and supporting Networking Events (Steps 3 & 4) activities to build an ecosystem that - UCSD fosters innovation. 510 + Events/years - UCLA - Princeton University We help commercialize or develop ideas and Seminars with Embassies and Governments concepts into products by organically connecting key - San Diego players in the life science field such as startups, large - Queensland, Australia corporations, academia and venture capital through - Sweden organizing events and programs. - Israel

Business Tours

We regularly host tours to visit the world’s life science clusters. You can experience each region’s cutting-edge research and network. • Singapore Life Science Business Tour • Eurobiomed Southern France Business Tour • San Diego Tour

Acceleration Programs

We organize programs such as “Out of Box Consulting Room” to discuss research concepts for free and “SAND BOX” which creates results through collaboration of a collective of students and young people from diverse backgrounds. We also organize our own pitch contest as well as co-sponsor entrepreneurial support programs hosted by venture capitals and accelerators with complementary agendas such as ZENTECH DOJO NIHONBASHI” (Sponsor: INDEE Japan) and “BRAVE” (Sponsor: Beyond Next Ventures).

3 4 Number of members, demographics 493 in Total Medical and social services: 2% IP and legal: 1% A wide range of key players from industry, government, and academia have joined us. Fields represented include VC: 4% Others: 5% pharmaceuticals, regenerative medicine, medical devices, Biomed and education and research, healthcare services, consulting, venture Medical and pharmaceutical: capital, intellectual property and law.(as of Mar 2021) testing devices Regenerative 12% medicine: 32% MEMBERS Membership A Medical IT 57 services Membership B 292 12% Membership C Education and Support for 144 research 12% commercialization Consulting 20%

Types of Membership

There are 3 types of LINK-J memberships: A, B, C. Membership A is for corporations with 100+ employees. Membership B is for corporations with up to 100 employees including startups and non-profit organizations (Universities, Research institute). Membership C is for individuals. The A and B memberships allow for the member organizations to use conference rooms and temporary Top players of the life science field all over the world working rooms for hosting meetings, events and receptions. are joining LINK-J. You can benefit by joining this network and becoming a part of our community. 490+ Members Membership A Membership B Membership C (Corporations) (Corporations and NPOs) (Individuals)

· Individuals such as doctors · Corporations with up to 100 · Employees and providers of employees corporations and organizations Corporations with 100+ employees · Non-profit organizations · Employees and providers of (Universities, Research institute) non-profit organizations · College and graduate students Enrollment fee: 100,000 yen Enrollment fee: 30,000 yen Enrollment fee: 2,000 yen Annual fee: 500,000 yen Annual fee: 120,000 yen Annual fee: 3,000-30,000 yen

Benefits

Events and Programs (Members’ special price)

Networking

Consulting by LINK-J Supporters

Use of the LINK-J Exclusive Communication Lounge (Complimentary)

Use of the Service Office (Separate contracts required)

Events and programs notification service on the LINK-J website and via e-mail

Publication on the homepage, brochure, etc.

Private use of the LINK-J Exclusive Communication Lounge (Members’ special price)

Use of the conference room or temporary working room (Members’ special price)

5 6 Domestic and International Collaborations

We have agreed on partnering with 16 organizations including universities around the world. We collaborate through hosting programs and events, exchanging publications, materials and information, providing services to each member, visiting, joint hosting and/or sponsorship of activities and collaborating on advertisements.

COLLABORATIONS Royal Danish Embassy One Nucleus Institute for Advanced Biosciences, Oxford University Innovation MedCity Keio University University of California, Los Angeles Medicen Paris Region Kanagawa Eurobiomed Osaka Kawasaki City BIOCOM Yokohama City

University of California, San Diego Kyoto Research Park

Foundation for Biomedical Research and Innovation at Kobe

LINK-J will continue to provide valuable information and Date of MOU signed Name of organization increased chances for networking in collaboration with May 2016 University of California, San Diego (UCSD), USA renowned institutions, organizations and universities 16 Collaborations across the world. May 2016 BIOCOM, USA

June 2017 Eurobiomed, France

July 2017 Kyoto Research Park, Corp., Japan

December 2017 One Nucleus, UK

Foundation for Biomedical Research and Innovation at January 2018 Kobe, Japan

April 2018 Institute for Advanced Biosciences, Keio University, Japan

June 2018 MedCity, UK

August 2018 City of Kawasaki, Japan

June 2019 University of California, Los Angeles (UCLA), USA

August 2019 City of Yokohama, Japan

July 2020 Oxford University Innovation（OUI）,UK

September 2020 Osaka, Japan

September 2020 Kanagawa, Japan

November 2020 Royal Danish Embassy

February 2021 Medicen Paris Region

7 8 Board members

Chairman of Chairman, Graduate School of Medicine, Keio University / Professor, Department of Physiology, Hideyuki Okano, M.D., Ph.D. the Board Graduate School of Medicine, Keio University Vice Chairman Yoshiki Sawa, M.D., Ph.D. Professor, Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine of the Board Director Takashi Ueda Executive Managing Officer, Co., Ltd. Director Akihiko Soyama President and Chief Executive Officer of Life Science Innovation Network Japan Auditor Yutaro Kikuchi Director, Kikuchi Sogo Law Office ORGANIZATIONS Auditor Shigeru Sugimoto Managing Partner, Sakura & Co. Management Advisory Committee

Special Advisor Yoichiro Matsumoto, Dr. Eng. President, Tokyo University of Science Special Advisor Shinya Yamanaka, M.D., Ph.D. Director and Professor, Center for iPS Cell Research and Application (CiRA) Kyoto University; Nobel laureate in Physiology / Medicine Special Advisor Peter F. Cowhey, Ph.D. Dean, School of Global Policy & Strategy, University of California, San Diego Advisor Takuro Ueda Director, Office of Cooperative Research and Development, Tohoku University Advisor Shinji Ohnish Kyushu University, Vice President Deputy Director General of Research and Industrial Collaboration Management office Advisor Hironori Kasahara, Ph.D. Senior Executive Vice President for Research and IT Promotion, Waseda University Advisor Hidetoshi Kotera Executive Director, RIKEN Advisor Isao Teshirogi, Ph.D. President, The Federation of Pharmaceutical Manufacturers' Associations of JAPAN (FPMAJ) / President and CEO of Shionogi & Co., Ltd. Our activities are supported by management advisory Advisor George Nakayama President, Japan Pharmaceutical Manufacturers Association (JPMA) / Former Chairman, Daiichi Sankyo Co., Ltd.. committee members and supporters who possess Advisor Ken-ichiro Hata, D.D.S., Ph.D. Chairman, Forum for Innovative Regenerative Medicine (FIRM) / President and CEO, Japan Tissue Engineering Co., Ltd. (J-TEC) specialized expertise and experience. Advisor Toshiaki Higashihara President & CEO, Hitachi, Ltd. The management advisory committee is composed 40+ Supporters Advisor Kenichi Matsumoto Chairman, the Japan Federation of Medical Devices Associations / Chairman, Sakura Global Holding Co., Ltd Advisor Masaaki Mizuno, M.D., Ph.D. Nagoya University Hospital Department of Advanced Medicine Center for Advanced medicine and of industry leaders who strongly support us with their Clinical Research Director , Clinical Professor broad-based knowledge and experience. They also Advisor Koji Murota Executive Vice-President for Industry-Government-Academia Collaboration, Kyoto University offer strategic advice to the Board of Directors. Advisor Toshiya Watanabe, Ph.D. Professor, Institute for Future Initiatives, University of Tokyo Advisor Masanobu Komoda President and CEO, Mitsui Fudosan Co., Ltd. LINK-J has recruited a number of supporters, people with knowledge spanning diverse fields and whose Supporters skill sets range from research and development to management, law and finance. Our supporters, who Masanori Akita MTI Ltd. Toru J. Seo, Ph.D. Pfizer Japan Inc. include entrepreneurs and experts, participate in many Tsuyoshi Ito Beyond Next Ventures Tohru Takashi, Ph.D. Japan Agency for Medical Research and Development Taro Inaba REMIGES Ventures Shunichi Takahashi, Ph.D. Bayer Yakuhin, Ltd. of the events that we organize together and offer one- Yo Iwami, M.D., Ph.D. MedPeer, Inc. Koichiro Tsujimaru, Ph.D. Tsujimaru International Patent Office on-one advice to LINK-J special members. Atsushi Usami, Ph.D. The University of Tokyo Edge Capital Co., Ltd. Shingo Tsuda INDEE Japan Ltd. Takahiro Uchida, M.D. Japanese Organization for Medical Takuma Nakatsuka POC Clinical Research Inc. Ph.D., MSc. Device Development, Inc. Hajime Oshita MedVenture Partners, Inc. Shogo Nishida Boston Consulting Group Jun Otomo, Ph.D. Hitachi, Ltd. Takato Noumi, Ph.D. FORESIGHT & LINX K.K. Hardy TS Kagimoto, M.D. Healios K.K. Nobuhiko Hibara, Ph.D. Waseda Business School Hiroaki Kato, M.D. Aillis Inc. Ryuji Hiramatsu, Ph.D. Foundation for Biomedical Research and Innovation at Kobe Hiroyuki Kanoh Forum for Innovative Regenerative Medicine Kinji Fuchikami Mitsui & Co. Global Investment, Inc. Tomy Kamada, Ph.D. TomyK Ltd. Ikkei Matsuda, Ph.D., MBA Science, Art & Research for Reconstruction (SARR) Makio Kitazawa Boston Consulting Group Masashi Matsunaga, Ph.D. Biospire Japan, Ltd. Hiroaki Kitano, Ph.D. Sony Computer Science Laboratories Mika Mizunuma, Ph.D. Craif, Inc Takashi Kiyoizumi, M.D., Ph.D. University of California, San Diego Keita Mori SanBio Company Limited Masashi Kiyomine Kicker Ventures Daiki Moriyama Deloitte Tohmatsu Venture Support Co., Ltd. Yohei Sawayama Coral Capital Yuji Yamamoto, M.D., MBA MinaCare Co., Ltd. Aki Shimauchi INDEE Medical, Inc. Masayuki Yokota Tokyo Stock Exchange, Inc. Tsutomu Sugaya Nobelpharma Co., Ltd. Hayato Watanabe, CFA Jadeite Medicines Inc. Rami Suzuki, Ph.D. Ferring Pharmaceuticals Co., Ltd. Ulrike Schaede, Ph.D. University of California, San Diego (UCSD)

9 10 Conference Rooms

There are various sized rooms that can be used for meetings, lectures, seminars, happy hours, special events, etc. These spaces are also equipped with sound and audio-visual facilities necessary for presentations. (Some incur extra charges) • Nihonbashi Life Science Hub • Nihonbashi Life Science Building • Nihonbashi Life Science Building2 FACILITIES • Lifescience Hub West • GLOBAL LIFESCIENCE HUB

Communication Lounges

The LINK-J Communication Lounge is exclusively for members. There are books, complementary drinks and snacks. The 10th floor lounge in Nihonbashi Life Science Building and foyer area of the Nihonbashi Life Science Hub is available for meets-and-greets, receptions, etc. • Nihonbashi Life Science Hub • Nihonbashi Life Science Building (1st and 10th floors) • Ueno Building We operate conference rooms and communication • Tosho Building lounges for the exclusive use of LINK-J members located • Lifescience Hub West • GLOBAL LIFESCIENCE HUB in the middle of Nihonbashi, an easily accessible center of business. We help you build a new network 10+ buildings and create your new business in a bright and open Temporary Working Rooms atmosphere.

On the 3rd floor of the Nihonbashi Life Science Building, there is a space that can be reserved on a per-day basis. (Up to 7 days)

Serviced Offices

We offer a wide-range of possibilities from secured individual booths to open desks and are pleased to accommodate your needs. You can also register this location as your office. This space is also furnished and does not require a deposit allowing you to keep your startup fee low. • 5th floor, Nihonbashi Life Science Building • Ueno Building • Tosho Building • Lifescience Hub West • GLOBAL LIFESCIENCE HUB

Offices and Laboratories

We rent out small to large sized offices to adjust to the size of your business. The wet lab facilities are necessary for practical application of research results and creation of innovation.

11 12 Location:

Exit 4 Exit 1 Tokyo Metro Hibiya Line Life Science Innovation Network Japan (LINK-J) Kodenmacho Station Exit 3 Address:2F Nihonbashi IT building, 3-3-9 Nihonbashi muromachi, Chuo-ku, Tokyo 103-0022, Japan Phone (within Japan): 03-3241-4911; Phone (outside Japan): +81-3-3241-4911 Fax (within Japan): 03-3241-3757; Fax (outsideSeijo Japan):IshiiIshiiSeijo +81-3-3241-3757 Sobu Line

Honcho ９ Exit 8 4 JR Sobu Rapid Line Exit 6 5 Shin-Nihonbashi Station Exit 5 3 ACCESS Tokyo Metro Hibiya Line Exit 4

Exit 2 Edo-dori Street Suginomori Shrine LINK-J Daiichi Sankyo Headquarters NOF Horidomecho Chuo-dori Street Nihonbashi Honcho Building Underpass １0 6 Nihonbashi Muromachi Exit A10 Mitsui Tower １ Exit A9 Doutor ■■Doutor Doutor ■■Doutor YUITOYUITO Lawson ■■Lawson Nihonbashi Astellas Exit A8 Fukutoku Shrine ■ Mitsui Building Tokyo Metro Hibiya Line Starbucks Tokyo Metro Line Honcho 2-chome Ningyocho Station Mitsukoshi-mae Station Exit A6 COREDO Muromachi 2 Horidome Children’s Park Nihonbashi COREDO 7 Exit A4 Mitsui Tower Muromachi 1 Exit A7 Bank of Japan Exit A5 Mitsui Main building 2 COREDO Muromachi 3 Exit A5 Toei Subway Asakusa Line Exit A4 Nihonbashi Life Science Facilities are located in a 8 Ningyocho Station Mitsukoshi Main building convenient location that is about a 10-minute walk from Exit A3 Seven-Eleven ■ Nihonbashi Honcho 2-3-11, Chuo-ku, Tokyo 103–0023 1.Tokyo Nihonbashi Metro Hanzomon Life LineScience BuildingExit A1 (LSB) Tokyo station and is accessible with many subway lines. Mitsukoshi-mae Station Mitsukoshi Annex building ■ Seven-Eleven 2. Nihonbashi Life Science Hub (HUB) Nihonbashi Muromachi 1-5-5, Chuo-ku, Tokyo 103–0022 Nihonbashi is also a place with a high concentration of Exit A2 3. Nihonbashi Life ScienceExit Building B4 Tokyo 2 (LSB2) Metro Hanzomon Line Nihonbashi Honcho 3-11-5,Toei Subway Chuo-ku, Asakusa Tokyo Line103–0023 commercial facilities with many historic buildings while 4. Tosho Building Nihonbashi Honcho 3-8-3, Chuo-ku, Tokyo 103–0023 being a robust hub of business activities. 5. MFPR Nihonbashi Honcho Building Nihonbashi Honcho 3-7-2, Chuo-ku, Tokyo 103–0023 We invite you to creatively innovate with us! 6. Ueno Building Nihonbashi Horidomecho 1-9-10, Chuo-ku, Tokyo 103–0012 7. LAUNCH Nihonbashi Ningyocho Nihonbashi Ningyocho 3-7-6, Chuo-ku, Tokyo 103–0013 8. Fukushima Building Nihonbashi Muromachi 1-5-3, Chuo-ku, Tokyo 103–0022 9. Nihonbashi Honcho 3-Chome Building Nihonbashi Honcho 3-8-5, Chuo-ku, Tokyo 103–0023 10. GLOBAL LIFESCIENCE HUB Nihonbashi Muromachi 3-2-1, Chuo-ku, Tokyo 103–0022

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11. Lifescience Hub West

Bingo-machi 4-1-3,, Chuo-ku, Osaka-city, Osaka, 541-0051

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