YEARS OF… YEARS OF…

RAMBAMHCC ANNUAL REPORT 2017 American Friends of Rambam www.aforam.org [email protected] (212) 292-4499

Australian Friends of Rambam www.ausforam.org.au [email protected] (61) 0410 531 593

British Friends of Rambam (Rambam UK) www.rambamuk.co.uk [email protected] (208) 343-8749

Canadian Friends of Rambam www.cfram.ca [email protected] (416) 481-5552

French Friends of Rambam [email protected] (33) 7 82 53 71 10

Friends of Rambam in India [email protected] (98) 191-113-40

Spanish Friends of Rambam www.amigosderambam.org [email protected] (609) 580-268

Israeli Friends of Rambam www.rambam.org.il [email protected] (04) 852-0670

Israel Main Office & All Other Countries www.rambam.org.il [email protected] +972 (4) 777-2919

Pictured on cover: Prof. David Ehrlich (l) and Prof. Ori Better, inducted into the Rambam Leadership Circle in 2017, with Nurse Ilana Ungerman-Tamir. Photo: December 1965 1940 1945

1938-48 Dr. John Herbert Thompson First Hospital Director

The graphic relief adorning the hospital’s I O A T N first building in 1938 was designed by the R U

world-renowned British sculptor and G

type designer Eric Gill U

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N I

1938 December 22 YEARS New Government Hospital OF Inaugurated in Bat Galim, Haifa EXCELLENCE, INNOVATION AND HUMANITY ’38

German Jewish expressionist architect Erich Mendelsohn 1950 1955

1948-63 Dr. Raphael Gjebin Second Hospital Director

1948-58 Elsa Yellin - First Head Nurse

I O A T N 1948 R U School of Nursing Established,

G Headed by Elsa Yellin

U

A

N I I O 1952 A T N R U Government Hospital

G Becomes Rambam

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1948 Following an attack on Kibbutz Gesher it was decided to evacuate all the mothers and children to the Carmelite convent next to the hospital

Declaration of ’48 Independence of the State of Israel 1960 1965

Dr. Moshe Lazar Third Hospital Director

1958-80 Rosa Haran - Second Head Nurse

I O A T N 1965 R U First Deceased G

U Donor Kidney

A 1967 N Transplant in

I Israel First Regional Installation of Hyperbaric Pressure Chamber 1962 New Outpatient Clinics Building Opens

1965 New Semilunar Model for Cardiac Intensive Care—First in the World at Rambam 1970 1975

1963-75 1975-79 Dr. Moshe Lazar Professor Reuven Eldar Third Hospital Director Fourth Hospital Director

1967 1978 First Regional Installation of Advanced Radioisotope Hyperbaric Pressure Chamber Imaging Comes to Rambam

1969 Establishment of the Faculty of Medicine

’73Yom Kippur War Forces Early Occupancy of New Hospitalization Building I O A T N R U

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U

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’67Rambam Treats Soldiers Injured in Six Day War 1985

1979-81 1981-86 Professor Reuven Eldar Professor Leon Epstein Professor Joseph Brandes Fourth Hospital Director Fifth Hospital Director Sixth Hospital Director

1980-83 Mazal Lubezki - Third Head Nurse

1982 The first Rambam logo 1983 New Protocol Developed 1978 for Treating Crush Syndrome—Now Used Advanced Radioisotope 1982 Worldwide Imaging Comes to Rambam The Medical Research Fund (Rambam Health Corporation) is Established 1985 First In Vitro Fertilization in the Region in Rambam’s Division of Obstetrics and Gynecology 1980 First Otolaryngological Laser Surgery in Israel

T I O N 1986 A 1978 R U

The Menashe Meyer G Rambam’s First Computed Children’s House U

Tomography System Installed A

N (Meyer Children’s I Hospital) Opens

’82Rambam is the Designated Hospital for Casualties During the First Lebanon War 1995 1990

1986-2005 Professor Moshe Revach Seventh Hospital Director

1983-97 Miriam Hasharoni - Fifth Head Nurse

1999 T I O N A Teaching Center for Trauma, R 1992 U

Emergency, and Mass Casualty G

U

First Stent Situations (MCS) Opens A

N Catheterization in I the Department of Cardiology

1995 Rambam Works 1998 with Biosense to Develop Cardiac Mapping System Discovery of Human Embryonic Stem Cells

I O A T N R U

G 2000

U

A

N I Vision of Adam (Humanity) ’90Rambam Patients & Staff 1994 Prepare for Chemical Warfare First Trauma Treatment During the Gulf War Center in Israel Opens at Rambam

1997 Discovery of DNA Markers that Identify the Jewish Priesthood 2000

1997-2015 Dr. Hanna Admi - Sixth Head Nurse

I O 2000 2001 A T N R U Development of GE Healthcare’s New

G Computerized PET-CT Imaging System

U

A Medical Records Developed at Rambam

N I System—Prometheus I O A T N R U

2002 G U

World’s First A N

Beating Heart Cells I from Embryonic Stem Cells

Collaboration With Given Imaging to Develop a Gastrointestinal Camera

2000 Vision of Adam (Humanity) Hospital Under Fire The Second Lebanon War 2005

2005 Rambam changes its identity from Medical Center to Health Care Campus

T I O N I O A A T N R R 2005 U U G

G Rambam Opens 12 New U

A

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A Fortified Surgical Suites I

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2008 Implementing the Clinical Research ‘Vision of Adam’ Institute at Rambam (CRIR) 2007 Established Establishment of First Competitive Research Programs for Clinician T I O N 2009 Scientists—Atidim A R Fortified & Ofakim U

G Emergency

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A Department

N I Opens

Hospital2006 Under Fire The Second Lebanon War 2010

2006-PRESENT Professor Rafi Beyar Eighth Hospital Director

RAMBAM Health Care Campus 2010 2013 The First Rambam Summit Creating the future of medicine. Rambam & Rambam Award graphic identity is restructured

2012 2014 I O Rambam MedTech Ltd. A T N R The Sammy Ofer Established U Fortified G

U Underground

A N Emergency

I Hospital Opens 2010 Rambam Maimonides Medical Journal is Launched

2013 MRI-Guided Focused I O A T N Ultrasound for R Treatment of National Biobank U

Essential and at Rambam G U

Parkinson’s Inaugurated A N

Tremor—First I in Israel

I O A T N 2014 R U

The Ruth Rappaport G

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Children's Hospital Opens A N

2011 I Da Vinci Robotic Surgical System Installed 2015

2015 - PRESENT Gila Hyams - Seventh Head Nurse

2017 Rambam Receives JCI Accreditation with 2015 Honors Rambam Knowledge

Center Established 2017 Cornerstone Laid for 2016 2018 Groundbreaking for Helmsley Health Discovery Tower The Joseph Fishman the Eyal Ofer Heart Oncology Center Hospital Opens I O A T N R U

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I O A T N Israel R U

G Celebrates

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I 70 2015 Rambam MindUp Incubator Celebrates Established 80

FROM THE DIRECTOR

Dear Friends to fruition through the establishment of the If I had to choose a single word to Helmsley Health Discovery Tower: a one-of-a- describe 2017 at Rambam, it would kind, multidisciplinary hub for healthcare, medical be “synergy.” This was the year research, education, and innovation. that Rambam joined forces with a Strategically positioned at the heart of a dynamic number of key strategic partners array of medical research and development to leverage our collective capacity activities, the Helmsley Health Discovery Tower for transformative health care. will have a profound and transformative effect on the world of medicine. It represents a unique The year began with the signing of a letter of collaborative model that is virtually unknown understanding between Rambam and the in Israel. Three distinct institutions – Rambam, University of Haifa, creating a unique partnership University of Haifa and the Technion – will have between the two institutions to jointly establish clinical, educational, and research departments a high-rise tower for research and education housed within its walls, facilitating collaborative on Rambam’s west campus. It ended with the opportunities via the surrounding clinical and landmark decision by The Leona M. and Harry B. innovation ecosystem. Additional facilities Helmsley Charitable Trust to bring this project within will be dedicated to the hi-tech medical

Professor Rafi Beyar RAMBAMHCC l 2017 ANNUAL REPORT

Eyal Ofer and Prof. Beyar breaking ground for the Eyal Ofer Heart Hospital industry, enabling on- The Joseph Fishman site consultations and Oncology Center is cooperation with clinical bringing the latest and research partners. The developments in cancer potential impact of such treatments to Rambam’s a critical mass of top level academic patients, with new linear and industry research activities cannot be accelerators that support precision treatments, overestimated. As Haifa mayor Yonah Yahav with minimal side effects, to our cancer patients. observed, the Helmsley Health Discovery Tower We expect the linear accelerators project to be will position Haifa as a center for life science completed during 2018. Patients at the center and biotechnology innovation and industry for are also are benefitting from the extensive clinical all of Israel. collaborations with the Technion Integrated Cancer Center (TICC), under the leadership of In another major development this year, ground Nobel laureate Professor Aaron Ciechanover. was broken for the new Eyal Ofer Heart Hospital. Mr. Ofer, his wife Marilyn and daughter Olivia, In early 2018, Rambam marked the passing of our attended the ceremony marking the continuation beloved friend and benefactress, Ruth Rappaport. of this historic partnership between the Ofer The patients and staff of Ruth Rappaport family and Rambam. We have worked closely Children’s Hospital were thankful to have had Ruth with the Eyal and Marilyn Ofer Family Foundation and her family here in 2017 to on the plans for the new hospital, towards a projected completion date in early 2019. The Rambam family says goodbye to a loyal and The Eyal Ofer Heart Hospital will provide visionary friend. Rambam with the most advanced means Ruth Rappaport of blessed memory to treat and prevent heart disease, the leading cause of morbidity and mortality in the Western world. Embracing the broadest of mandates for promoting heart health, the Eyal Ofer Heart Hospital will provide advanced cardiac care, support cutting- edge research, and offer risk-reduction programs to promote a healthier Israeli society. We especially appreciate the astute guidance of Olivia Ofer, whose commitment celebrate her 93rd birthday together. to realizing the vision of the planned hospital Her memory will be blessed and her name will always is exemplary. be associated with loving care for the health and wellbeing of the children of northern Israel.

3 FROM THE DIRECTOR

Architectural rendering of Helmsley Health Discovery Tower

places special focus on Rambam’s and Israel’s contributions to medical excellence and peacebuilding through healthcare.

Professor Horton was one of the notable guests at the 2017 Rambam Summit, along with Jeffrey M. Drazen editor-in-chief of The New England Journal of Medicine, both of whom received the 2017 Rambam Award. Also at the summit, guests were intrigued to hear insights from another distinguished guest and 2017 Rambam Award recipient, former Ambassador to Israel, Dennis Ross, on his experiences of the Middle East peace process during Among the many clinical developments over the his tenure. year, we marked the opening of the Herta and Paul Amir Neurosurgery Intensive Care Unit, On the research front, Rambam MedTech, which is now fully occupied. We also opened a Rambam’s technology transfer unit, continues new Diabetes and Obesity Center of Excellence to help our nurses and physicians develop their which incorporates a promising new approach innovations into commercially viable products. for treating patients of all ages, ensuring a During 2017, Rambam researchers were awarded personalized and uninterrupted continuum of care. a number of major national and international Rambam’s excellent Department of Nephrology research grants, including grants from the Chief will be enhanced thanks to a gift from the Harvey Scientists of the Ministries of Health and Industry. and Gloria Kaylie Foundation to create the Kaylie Kidney Health Center of Excellence. We continue to serve as a clinical partner for leading medical technology innovators, The historic dialogue between Israeli academics including InSightec, with its revolutionary MRI- and the editor-in-chief of The Lancet, Professor guided Focused Ultrasound technologies. The Richard Horton, initiated by Rambam in 2014, company’s non-invasive neurosurgical therapy reached a significant milestone in May 2017 to control Parkinson’s and essential tremor has with the publication of a special Lancet edition been used at Rambam to treat some 65 patients highlighting “Health in Israel.” The special issue from around the world, with amazing results. RAMBAMHCC l 2017 ANNUAL REPORT

we thank all our friends around the world for being part of our vision and helping us to achieve our missions.

This past year will be remembered as the conjoining of diverse stakeholders for the advancement of medical This past year, the MINDUp Digital Medicine care and research to the benefit of the people incubator, in which Rambam is a clinical partner, of our region, our nation, and our world—a moved to its new facility in the Haifa Life Sciences representation of synergy at its very best. Park. The incubator has already evaluated some 250 startups in the field of digital health, and accepted The year 2018 marks Rambam’s eightieth six of them, while another four are in the application anniversary. Looking at the original and beautiful process. The companies offer technologies for stone monastery where it all started, and the pain relief, neurological disorders, and respiratory modern, vibrant campus that has grown up monitoring, among others. around it, one cannot help but wonder what will be achieved by Rambam’s centennial. But of As the major teaching hospital for the Technion’s one thing I am convinced: with the synergy and Rappaport Faculty of Medicine, we continue to support of our partners, no dream is too small. attract bright young physicians and scientists. As they finish medical school, many choose Yours, to stay on as residents, some as part of an MD-PhD program. The new energy, talent, and commitment these young residents bring to

Rambam contributes to our vitality and ability Rafi Beyar, MD, DSc, MPH to stay abreast of new developments. Director & CEO Rambam Health Care Campus

As much as Rambam expands and offers new services, the demand for them grows even faster. In spite of the challenges, we are maintaining the momentum that has driven one of the most remarkable development plans of any hospital in Israel’s history. We are gratified to see how our energy and enthusiasm inspire others, and

5 COMING TO RAMBAM “felt like coming home”

PROFILE

When Dr. Eitan Abergel, Director of the Invasive Neuro-Radiology Unit, came to Rambam from France for a six-month professional visit, he never imagined that the course of his professional career, and his entire life, would drastically change.

What did you find when you got here? open blocked coronary arteries. At that At Rambam I met with Professor Beyar who time, mechanical intervention was being told me they were looking for someone in experimentally applied in the field of neuro- interventional cardiology. I liked what I saw here radiology to open blocked brain vessels during and everyone was so friendly, I immediately felt stroke. Prof. Beyar wanted to reinforce this right at home. Professionally, I was impressed experimental thrombectomy approach at with the cutting edge technologies they were Rambam. When he couldn’t find anyone in using. After finishing my six months, I decided to neurology willing to learn the new technique, he stay for six months more. When the nurses heard asked if I was interested. My entire professional that I am single, one of them introduced me to identity was as a cardiologist, and it wasn’t an her cousin, who is now my wife. easy decision to switch careers. I discussed the issue with my wife, and decided to go ahead. And then you made a radical change. The next step was to find a place to train. Until I came to Rambam as an interventional now, this type of procedure was exclusively cardiologist specializing in angioplasty to performed by either radiologists, neurosurgeons RAMBAMHCC l 2017 ANNUAL REPORT

“It was actually my father’s idea for me to come work in Israel,” Dr. Abergel admits. “He is Israeli and my mother is French. I was born in Israel but we moved to France when I was 11, and I finished school and medical school in Lyons. After my residency and fellowship in interventional cardiology, I decided to take a break. That’s when my father suggested I come to Israel.”

or neurologists. I applied to 37 hospitals in France, And when you returned? but no one wanted to accept a cardiologist. Finally, Performing this procedure is very difficult, so I a hospital in Montpellier agreed to train me and was under a lot of stress. But now, after a year and we moved to France for one intensive and amazing a half, we are the largest center in Israel offering year. I trained from 7 AM to 8 PM every day, and this type of stroke treatment. In 2017, around 400 worked on the weekends to maximize my time there. thrombectomies were performed in nine hospitals in all of Israel. And 107 of them – 25% - were performed Your career change was a radical here at Rambam. departure from convention. Making the transition from cardiology to We are available to treat stroke patients 24/7. Now, on neurointervention is entirely unique. Only a few the weekends when we visit my wife’s family, we always people in the world have done it and I’m one of take two cars. Because I never know when the call that them. There were many in Israel who objected, I’m needed at the hospital will come. including the neurointerventionalists. Yet Prof. Beyar fully supported me.

7 Helmsley Health Discovery Tower

With support from The Leona M. and Harry B. Helmsley Charitable Trust, a unique partnership is scaling the heights of healthcare innovation.

Israel’s unique status as institutions: Rambam, strengthen the region, and “the Startup Nation” is now University of Haifa and the support greater collaboration legendary. But experience Technion. Within the planned among Rambam, University of has shown that having 20-story structure, space Haifa, and the Technion—three good ideas is not enough, will be allocated to each of Israel’s great institutions— and that creativity and of the partners for their as well as with the medical innovation need a supportive dedicated healthcare, teaching and biotech industry.” The environment to truly thrive. and research activities. project’s shared mission of This is the vision behind Furthermore, it will provide a excellence in healthcare and the new Helmsley Health fertile environment for medical promoting medical innovation Discovery Tower. innovation development by is consistent with the goals industry startups. of the Helmsley Charitable Helmsley Health Discovery Trust, to strengthen healthcare Tower is an entirely unique Mr. Sandor Frankel, a trustee services and contribute to concept – a world-class of The Leona M. and Harry Israel’s scientific, technological hub of innovation in life B. Helmsley Charitable and medical leadership. sciences, public health, Trust, observed that the biomedical engineering, and new tower “… will improve Israel’s Minister of Finance, pharmaceutical research, access to health care in the Mr. Moshe Kahlon, celebrated shared by three partner northern periphery of Israel, the new initiative as a flagship RAMBAMHCC l 2017 ANNUAL REPORT

A NEW PARADIGM FOR BIOTECH DISCOVERY

TWENTY FLOORS

9 project for the city of Haifa University of Haifa will occupy to Rambam’s clinical and northern Israel. And six floors with research departments will facilitate Prof. Rafi Beyar, Rambam’s centers in public health, collaborations to develop and Director and CEO, noted that evidence-based nursing, and test new medical innovations, the new project will enable us health and natural sciences. to benefit patients at Rambam “to help not only the people The Technion’s Faculty of and around the world. of Israel but to impart critical Medicine will use two floors knowledge across the globe.” for a new multidisciplinary These days, Israel’s medical engineering center, biomedical innovation A Dynamic Hub for and the top four floors will Medical Innovation house an “Innovation Center,” The tower’s ground floor with facilities where Rambam will feature a Congress and physicians and local and Exhibition Center for the use international biomedical of all the tower’s occupants. startups can test and develop Two floors of the Helmsley their commercially viable ideas. Health Discovery Tower will house laboratories for the Creativity, Collaboration Clinical Research Institute and Convergence at Rambam (CRIR) working Helmsley Health Discovery in the fields of hematology, Tower has been designed to nephrology, cardiovascular create a fertile microcosm medicine, gastroenterology, where the most creative brain and neuroscience, ideas can be conceived and cancer, diabetes, obesity and developed. The proximity of endocrinology. The five floors professionals from different above CRIR will accommodate medical disciplines will Rambam’s Ophthalmology foster the kind of dialogue Institute, Gastroenterology that can spark game- Institute and School of changing breakthroughs. Graduate Dentistry. And the convenient access RAMBAMHCC l 2017 ANNUAL REPORT

ecosystem is thriving, and and wearable medical was also instrumental in Rambam is a key player in devices. At the heart of this developing Rambam’s Sammy developing new medical dynamic medical innovation Ofer Fortified Underground technologies. Rambam cluster, the Helmsley Health Hospital. In recognition of their offers research grants and Discovery Tower will secure extraordinary commitment to the support of Med-Tech, Rambam’s position as a basic improving healthcare for the the technology transfer and clinical research leader, in people of Israel, and especially unit established to help Israel and worldwide. those living in Israel’s Rambam’s physicians periphery, The Helmsley and nurses develop their A Partnership Based on Charitable Trust and Trustee promising ideas. Through Shared Vision Sandor Frankel received the its partnership in the digital Mr. Sandor Frankel, a Trustee 2016 Rambam Award. medicine incubator, MindUP, of the Helmsley Charitable Rambam is collaborating Trust, and his wife, Ruth, are with IBM, MedTronic, Pitango dedicated and passionate Venture Capital and Impact supporters of Israel. The First Investments to develop vision and support the next generation of of the Helmsley digital medical applications Charitable Trust Helmsley Health Discovery Tower will be erected on Rambam’s West Campus, one of the most ambitious expansion plans in Israeli history.

Rambam has built, from the ground up – and down – an entirely new and modern campus, designed to foster excellent and secure medical care and innovative research. On the new West Campus, Helmsley Health Discovery Tower will join the Sammy Ofer Fortified Underground Hospital, one of the largest facilities of its kind in the world, the spacious and modern new Ruth Rappaport Children’s Hospital and Joseph Fishman Oncology Center, and the state-of-the-art Eyal Ofer Heart Hospital, now under construction.

11 READY, SET, HEAD UNDERGROUND

Imagine the city of Haifa is under missile attack. For Haifa residents and Rambam staff, this nightmarish scenario is still fresh in their memories from the summer of 2006, when missiles launched from Lebanon wreaked havoc across the city.

But now imagine that some of those missiles are bearing chemical warheads… RAMBAMHCC l 2017 ANNUAL REPORT

“Protecting our patients and healthcare providers under any circumstances is imperative. We are grateful to our supporters who share this commitment, and who enabled us to build and outfit this emergency facility that is unique in the world.” - Prof. Rafi Beyar Director and CEO Rambam Health Care Campus

n October 2017, Rambam held a major drill simulating a non- conventional weapons attack, in collaboration with the IDF IHome Front Command, Magen David Adom, and various government ministries. Hundreds of emergency hospital personnel, emergency medical teams and soldiers took simulated roles in the drill.

For Rambam, this was an opportunity to practice converting the Sammy Ofer Fortified Underground Emergency Hospital from a parking lot into a fully-functioning treatment facility, ready to admit waves of severely injured military and civilian casualties. And for all involved, there was satisfaction in its outcome.

13 RAMBAM MEETS JCI GLOBAL HEALTH STANDARDS n 2017, Rambam Healthcare Campus was accredited by the Joint Commission International (JCI), an accrediting organization for health care institutions Iaround the world, based on compliance with best practices in quality and patient safety. A team of JCI inspectors spent five intensive days investigating the healthcare campus before concluding that Rambam meets their stringent international standards. RAMBAMHCC l 2017 ANNUAL REPORT

L-R: Accreditation team members Koby Shir Moskovitz, Hagar Baruch, Dr. Fuad Basis

RAMBAM ACCREDITED 2017

Receiving accreditation from JCI on the first round is notable for a large government hospital, and Kobi Shir Moskovitz, Rambam’s Operation Manager for Medical Technology and Emergency, and a member of the accreditation team responsible for the process, took special pride in the achievement.

“Securing accreditation is one thing,” Kobi explains. “But maintaining it is another. We have had to instill an entirely new organizational culture, from the kitchens and laundry rooms to the operating suites. And making sure that the staff receives periodic training and is kept up to date on new standards is an ongoing commitment. We have created a website, newsletter and even an app for smartphones, to keep awareness high.”

15 Dr. Shlomit Strulov Shachar Recipient of the 2015 Jacob and Gitla Zukier Oncology Fellowship & a Horizons Award for 2017

RESEARCH HIGHLIGHT

62 Customized IS THE AVERAGE AGE AT WHICH BREAST CANCER Cancer IS DIAGNOSED Treatment 1 in 3 cancers in women for Older is Breast Cancer BREAST CANCER IS Patients THE MOST COMMON CANCER AMONG WOMEN IN THE UNITED STATES MOST WOMEN WHO SUCCUMB TO BREAST CANCer ARE OVER 65

WHAT ARE THE HORIZONS (OFAKIM) RESEARCH AWARDS?

Horizons Awards are given to Rambam physicians at the n her work medical journals, have been pivotal in catalyzing beginning of their careers, as a medical a shift towards more personalized cancer who are poised to open new horizons in their pre-clinical oncologist, treatments for older patients. and clinical research. The Dr. Shlomit award provides funding to IStrulov Shachar In 2017, Dr. Strulov Shachar received a Horizons pursue promising lines of research. questioned why Grant from Rambam to conduct a prospective older adult patients cohort study on muscle mass and other geriatric were receiving the same chemotherapy dosages assessment factors, aiming to identify key criteria as young adults, often to their detriment. As a for optimizing personalized cancer treatments. Zukier Oncology Fellow, she was able to pursue She has been invited to speak at the US National this line of inquiry by conducting a retrospective Institute of Health, and is planning pharmacology study on the outcomes of older cancer patients collaborations to develop new cancer dose criteria based on their body muscle mass/quality. The based on body composition metrics. findings from that study, published in major RAMBAMHCC l 2017 ANNUAL REPORT

The combination of an aging population with an increased incidence of breast cancer and other comorbidities related to aging makes management of this expanding group of older patients a major challenge.

Treatment of breast cancer in the elderly is especially challenging as older adults, even those with normal performance status, are more likely to have physiological changes, functional deficits, comorbid medical conditions, and polypharmacy, which increase the risk of treatment toxicity.

BODY COMPOSITION WHAT ARE THE AND TOXICITY IN EARLY Zuckier BREAST CANCER Fellowships?

Jacob and Gitla Zukier Oncology Fellowships subsidize clinical fellowships in leading overseas medical institutions for doctors from the Department of Oncology at Rambam NORMAL SKELETAL REDUCED SKELETAL MUSCLE DENSITY MUSCLE DENSITY

17 Dr. Hadar Zigdon-Giladi Horizons Research Grant Recipient

RESEARCH HIGHLIGHT FERTILE GROUND FOR BONE REHABILITATION RAMBAMHCC l 2017 ANNUAL REPORT

CELL TRANSPLANTATION IN BONE SCAFFOLD

CELL CELL IDENTIFICATION HUMAN-DERIVED CULTURE endothelial progenitor stem cells CELL ISOLATION Intimate proximity between bone and vessels

REGENERATED BONE

Dr. Hadar Zigdon-Giladi, a physician in the Department of Periodontology, applied her Horizons Research Grant to develop a new technique for bone rehabilitation using endothelial progenitor stem cells harvested from the patient and transplanted to the site of bone loss.

he transplanted cells initiate the formation of new blood vessels which is essential to support bone regeneration, overcoming the most common obstacle to successful bone grafting. While endothelial progenitor stem cells are Twidely researched in the field of cardiology, Dr. Zigdon-Giladi is one of only a few researchers exploring their use for bone regeneration applications.

Dr. Zigdon-Giladi, a member of the Clinical Research Institute at Rambam, hopes that her stem cell-based research will ultimately translate into improved treatments for patients with jaw bone degeneration due to birth defects, injury, or cancer. Research funded by her Horizons grant has earned Dr. Zigdon-Giladi a number of competitive grants, including two grants from the prestigious Israel Science Foundation.

19 Dr. Rostislav Novak Recipient of a 2014 Leaders Research Program Award

RESEARCH HIGHLIGHT INVESTIGATING THE GENETIC UNDERPINNINGS OF BONE CANCER RAMBAMHCC l 2017 ANNUAL REPORT

RNF4 STABILIZES and POTENTIATES KEY ONCO-PROTEINS

Lys33 BETA-Catenin c-Myc Ub Mitogenic RNF4 Ub c-Jun Signaling NICD Ub Ub Lys11 Ub P P ONCOPROTEIN STABILIZATION & ACTIVATION

ONCOPROTEIN ONCOPROTEIN ONCOPROTEIN

Oncoproteins are proteins encoded by oncogenes involved in the regulation or synthesis of proteins associated with cancer tumor cell growth.

Fresh into his medical career, Dr. Rostislav Novak is already balancing his clinical work as a resident in orthopedic oncology with research studying cancer in bone and soft tissue.

WHAT IS THE is specific area of interest is the dependency of cancer LEADERS (ATIDIM) cells on “nononcogene addiction” (NOA) genes and their Award? role in cancer cell survival and proliferation. Leaders Awards are given to outstanding HIn 2014, Dr. Novak received a Leaders Research Program Award to medical residents who demonstrate study osteosarcoma, a devastating form of childhood bone cancer, exceptional clinical and under the supervision of Professor Amir Orian of the Technion’s scientific promise. The Rappaport Faculty of Medicine. Current therapy for osteosarcoma award brings with it an allocation of time and is limited, such that insights from Dr. Novak’s efforts to identify funding to pursue the molecular targets for the disease have far-reaching implications awardee’s research for the development of new therapeutic approaches. Without the program. funds, facilities and mentorship provided by the Leaders Research Program Award, Dr. Novak would not have been able to pursue this promising research program.

21 Dr. Jacob Cohen and Professor Ziv Gil Recipients of a Kamin Grant 2017 from the Israeli Ministry of Industry and Trade, after receiving a 2013 Spark (Nitzotz) Grant

RESEARCH HIGHLIGHT AN NTP APPROACH TO CANCER TREATMENT

True innovation often arises from knowledge that spans disciplines. This is the case with Dr. Jacob Cohen, who heads Rambam’s Voice and Hearing Unit, but also has a passion for physics.

WHAT IS NON- THERMAL PLASMA?

Also referred to as cold plasma, non-thermal plasma (NTP) is partially KILLING CANCER ionized gas where the NTP SELECTIVELY energy is stored mostly in the free electrons and the overall temperature remains low.

TECH TRANSFER

RAMBAM MEDTECH RAMBAMHCC l 2017 ANNUAL REPORT

WHAT IS THE SPARK n 2017 Dr. Jacob Cohen and Prof. Gil Ziv, Director of the (NITZOZ) PROGRAM? Department of Otolaryngology–Head & Neck Surgery, and a The Spark Program team of collaborators, were awarded a Kamin Grant from the provides funding to help Israeli Ministry of Finance and Trade to develop a radically Rambam physicians develop promising Inew and promising approach to treating cancer using precision- innovations into application of non-thermal plasma (NTP). successful products for the benefit of patients worldwide. The funds This prestigious grant funds the continuation of a promising research are used to determine project that was originally supported by a 2013 Spark (Nitzotz) Grant feasibility for very early the scientists received from Rambam. stage projects with a high probability of success. NTP has been found to selectively kill cancer cells without harming adjacent healthy tissue, and without the harsh side-effects associated with chemotherapy. With their Spark Grant, the team is now testing an innovative periscopic/endoscopic fiber instrument they have developed that can deliver non-thermal plasma directly to a tumor. With help from MedTech, Rambam’s technology transfer unit, they hope to secure funding to create a startup dedicated to bringing this low-cost, minimally-invasive, safe and reliable treatment method to the bedside.

Dr. Jacob Cohen (l) with Prof. Ziv Gil

23 TECH TRANSFER 1/2 M SHEKELS TO DEVELOP A BETTER ORTHOPEDIC SOLUTION

ed up with a bone anchoring system that never seemed to fit their patient’s anatomy, Dr. Yaniv Keren and Dr. Yaron Berkovitz of Rambam’s Orthopedic Surgery Department came up with an idea for how to improve it. With a seed grant from Rambam’s Nitzotz (Spark) Fprogram, they built a prototype that was persuasive enough to win a half- million NIS (about $145,000) development grant from the Chief Scientist of the Ministry of Health.

Nitzotz grants are offered under the auspices of MedTech, Rambam’s technology transfer unit and incubator for applied research. MedTech recognizes that some ideas can come only from those working inside the field, as demonstrated by Dr. Keren and Dr. Berkovitz. And when those insights come, MedTech helps bring them closer to realization. RAMBAMHCC l 2017 ANNUAL REPORT

Dr. Yaniv Keren (l) and Dr. Yaron Berkovitz

25 AN ISRAELI BREAKTHROUGH IN CHF TREATMENT IS FIRST TESTED AT RAMBAM

Prof. Gil Bolotin with patient

Diastolic Congestive Heart Failure

NORMAL HEART HEART WITH DIASTOLIC CONGESTIVE HEART A 72-year-old Canadian man recently FAILURE became the first in the world to benefit from a revolutionary new Israeli treatment for Diastolic Congestive Heart Failure (CHF), a debilitating condition affecting millions which leads to fatigue, shortness of breath and respiratory complications. The patient came to Israel and Rambam for a minimally invasive procedure to

STIFF HEART implant a small elastic device, called a MUSCLE LESS BLOOD CAN’T RELAX CORolla, in his heart. FILLS THE CORRECTLY VENTRICLES RAMBAMHCC l 2017 ANNUAL REPORT

According to the World Health Organization (WHO), cardiovascular diseases are responsible for more deaths than any other medical condition worldwide.

What is CHF? he CORolla was developed by Dr. Yair Peled, a senior

Heart failure, cardiologist at Rambam, and implanted by Prof. Gil Bolotin, sometimes known Director of Rambam’s Cardiac Surgery Department. It as congestive heart incorporates a simple and elegant design that uses energy failure, occurs when the heart muscle Tgenerated by the heart to augment its diastolic relaxation capacity. doesn’t pump blood as The innovative procedure, which was performed by Prof. Bolotin, has well as it should. generated great interest around the world. Certain conditions, such as narrowed “Over 40% of patients in this patient’s condition have a life arteries in the heart (coronary artery expectancy of only five years after first diagnosis,” explains Prof. disease) or high blood Bolotin. “With this very simple mechanical solution, we actually pressure, gradually attempt to solve a medical problem that until now has had no cure.” leave the heart too weak or stiff to fill and pump efficiently.

27 RAMBAM DOCTORS ON CALL AT THE MACCABIAH GAMES

The 20th Maccabiah Youth Games took place this year in Haifa, with Rambam appointed as official medical care provider for the young athletes. RAMBAMHCC l 2017 ANNUAL REPORT

ver the two weeks of games, Rambam’s physicians treated some 50 participants for conditions ranging from heatstroke to sports injuries and even scorpion bites!

OIn a touching example of the small Jewish world, Prof. Norberto Krivoy, a veteran Rambam physician and immigrant from Argentina, was able to watch his grandson compete in the games.

According to Dr. Michal Mekel, Deputy Director of Rambam, and the one responsible for Rambam’s medical care at the Youth Maccabiah, “We were prepared for any scenario, but everything went smoothly and our staff was able to enjoy the games.”

29 BIG “ BIG DATABIG Sara Tzafrir Director of Rambam’s Division of Information, Computing ANSWERS and Communications BIGDATARAMBAMHCC l 2017 ANNUAL REPORT

“This technology will facilitate a giant leap in medical knowledge by enabling research using big data across large sectors, quickly, accurately and cost-effectively, but most importantly ensuring the anonymity of patients.”

- Rafi Beyar, Director and CEO, Rambam

edical research analyzing The parallel data can be used vast amounts of clinical for research purposes without data just got much compromising patient anonymity. “easier, thanks to a new Mcollaboration between Rambam and The pilot project was conducted in Israeli startup MDClone. As part of a collaboration with a study led by Dr. pilot study led by Sara Tzafrir, Director Irit Hochberg of the Endocrinology and of Rambam’s Division of Information, Diabetes Research Institute aimed at Computing and Communications, identifying risk factors among diabetic Rambam became the first hospital in patients for developing hypoglycemia the world to test a new technology during hospitalization. Dr. Hochberg which, when applied to hospital records found that the MDClone system systems, creates “clones” of patient performed as well as traditional data records that are stripped of any collection and analysis techniques. identifying patient information.

31 Visits and Revisits Israel

“Our ultimate goal is the entirely achievable imperative of harmonious wellbeing for the diversity that comprises the people of Israel and beyond.”

- Excerpt from Israel: health and beyond, by Karl Skorecki, Richard Horton, in The Lancet RAMBAMHCC l 2017 ANNUAL REPORT

L-R: Professor Richard Horton and President of Israel, Reuven Rivlin

The June 24-30 2017 issue of The Lancet, one of the world’s most prestigious medical journals, featured a series on healthcare in Israel, with articles on topics ranging from maternal and child health, inequalities in non- communicable diseases between major population groups, and the treatment of casualties of the Syrian Civil War, as well as an essay on medical ethics in Israel. An article jointly authored by Lancet Editor-in-Chief Richard Horton and Rambam’s Prof. Karl Skorecki, Director of Medical and Research Development, describes the origins of their collaboration and the idea for the special Israel Series.

Three years earlier, they recall, The Lancet published a letter critical of Israel during Operation Protective Edge. The letter sparked an international storm of controversy. But it also inspired Prof. Rafi Beyar, Rambam’s Director and CEO, and Prof. Karl Skorecki to invite the journal’s editor to come to Israel and evaluate the situation for himself. Prof. Horton accepted the invitation, and was sufficiently impressed by what he saw to dedicate a special series on healthcare in Israel. This issue, it is hoped, will spark a different kind of debate, and a new understanding and appreciation of Israel’s remarkable achievements in health care in the region.

33 Dr. Marielle Kaplan (second from left) with team members in the Clinical Biochemistry Lab

CLINICAL BIOCHEMISTRY LAB

Dr. Marielle Kaplan has worked in labs at Rambam for 17 years, and has led the Clinical Biochemistry Lab for 10. As Rambam continues to grow and expand, the Clinical Biochemistry Lab is called upon to fulfill ever-increasing testing demands in a timely manner, without compromising on accuracy. In 2017, Dr. Kaplan and her team achieved all that, and more. RAMBAMHCC l 2017 ANNUAL REPORT

very day we perform 1000 We are also integrated into the diagnostic process routine lab tests for the entire for rare syndromes, particularly in infants born hospital, using 400 different with unexplained syndromes. We work with the testing procedures. We try to neonatologists and the Genetics Institute to “Erelate to each test with the care we would give to provide data, but also our insights.” an individual patient. - Dr. Marielle Kaplan

This past year, we upgraded our equipment which enabled us to reduce the turnaround time for delivering routine test results by half, and almost as much for tests coming from the ER.

35 DONOR PROFILE D. Dan and Betty Kahn Foundation and Andrea and Lawrence A. Wolfe

ewish life, Israel and Together, the Wolfes are continuing the education. These are Kahn family’s extraordinary legacy of Jdefining values that support to higher education in Israel in characterize the philanthropic general, and the Technion in particular. vision of both the Kahn In addition to establishing the D. Dan Foundation and Andi and Larry and Betty Kahn Mechanical Engineering Wolfe of Detroit, Michigan. Building at the Technion, the D. Dan and Betty Kahn Foundation has been Andrea, daughter of the late instrumental in bringing together D. Dan and Betty Kahn, sits leading researchers from Michigan on the board of ORT America and and Israel to collaborate on scientific of the Technion-Israel Institute of advances to improve human health. Technology’s Board of Governors. Her husband Larry serves on the boards In their home community, Larry of the American Friends of Rambam served as the president of the Jewish (AFORAM), and World ORT. Federation of Metropolitan Detroit, RAMBAMHCC l 2017 ANNUAL REPORT

and his vision guides a number of the In 2015, the D. Dan & Betty Kahn region’s Jewish cultural and educational Foundation Pediatric Pulmonary institutions. He has also been Unit was opened in Rambam’s Ruth instrumental in advancing the goals Rappaport Children’s Hospital, with the of the Federation’s Israel Overseas support of the Foundation (trustees: Committee, and was the chair of the Lawrence Wolfe, Patrice Aaron and State of Israel Bond Campaign for Arthur Weiss). The unit is improving Detroit. Andi currently sits on the board the quality of care for the steadily of Jewish Family Services, and both rising number of children in northern Andi and Larry sit on medical advisory Israel suffering from asthma, cystic boards of the University of Michigan. fibrosis and other pulmonary diseases. Research conducted under the The Wolfe’s continued connection auspices of the new unit is pointing to Haifa brought them to Rambam the way to new and more effective Health Care Campus, where they found treatment approaches for children a cause worth supporting. Indeed, suffering from lung diseases. Larry is a valued member of the Board of Directors of American Friends of Rambam is profoundly grateful for Rambam. Now, each return visit they its friendship with Andi and Larry make to Rambam adds warmth and Wolfe, as well as the D. Dan and Betty depth to the relationship. Kahn Foundation, and honors their exceptional commitment to Israel’s healthcare and educational institutions.

37 Dear Friends,

t was almost fifteen years ago when, These impressive, modern facilities, along with together with Eitan and Ariella Wertheimer, the innumerable improvement projects that have Rambam’s leadership conceived the master raised Rambam’s clinical and research capabilities plan to develop Rambam’s West Campus. to new heights, are a testament to what shared ISince then, with the support of dedicated vision and commitment can achieve. partners from around the world, the Sammy Ofer Fortified Underground Emergency Hospital, Two major milestones achieved in 2017 have Ruth Rappaport Children’s Hospital and Joseph brought us closer than ever to completing the Fishman Oncology Center have come into being. West Campus project. A lead gift from the Eyal RAMBAMHCC l 2017 ANNUAL REPORT

Another extraordinary gift, from the Leona and Harry B. Helmsley Charitable Trust, will enable us to establish the unparalleled Helmsley Health Discovery Tower, a joint venture with the University of Haifa. We thank Helmsley Trustee Sandor Frankel and his wife Ruth for their warm friendship and commitment to our shared goals. The impact the Eyal Ofer Heart Hospital and the Helmsley Health Discovery Tower will have on local and global health is immeasurable.

At Rambam, we have never been afraid to dream on a large scale. The West Campus project is one of the most ambitious and transformational initiatives ever undertaken by an Israeli hospital. Yet the scale of our ambitions stands in direct proportion to the challenges of carrying them out. This is why our friends and supporters have such a key role to play.

Over the past year, it has been our pleasure to host and honor many cherished friends who have visited us from all corners of the globe. This past year also saw an impressive number of events hosted by our organizations of friends around the world. I invite you as well to stay abreast of the transformative work we are doing and Marilyn Ofer Family Foundation paved the way here at Rambam during your next visit to Israel. for construction of the Eyal Ofer Heart Hospital. The opportunities you will find for meaningful With this gift, we have reinforced a wonderful partnership are inspiring! partnership with the next generation of the Ofer family, through the invaluable involvement of Eyal and Marilyn Ofer’s daughter Olivia, who heads the Yours, family foundation. Dr. Esty Golan

39 RAMBAM IN 1938 6,000 0 patients treated oupatient clinics 220 beds 1 delivery room 100 staff 1 research lab 3 inpatient 3 departments operating rooms 0 institutes

RAMBAM THEN & NOW RAMBAM IN 2018 260,000 113 patients treated oupatient clinics 1,000 beds 11 delivery rooms 5,150 staff 15 research labs 57 inpatient 17 departments operating rooms 39 institutes 2017 IN NAMES & Numbers

This year, we celebrate 80 YEARS of Excellence, Innovation and Humanity RAMBAM’S FRIENDS CIRCLES YOUR VISION AND MAIMONIDES GOLDEN GENEROSITY IS HELPING CIRCLE

US TO CONSISTENTLY Donors who have had an immense impact in helping to position, shape, and advance our RAISE THE BAR. hospital in a profound and meaningful way.

With your help, Rambam has grown into one of Israel’s most important centers for medicine and research. Each gift, from the transformational to the personal, has given us the means to make Rambam Health Care Campus a point of reference worldwide.

American Friends French Friends of Rambam of Rambam

Australian Friends Friends of of Rambam Rambam in India

British Friends Israeli Friends of Rambam of Rambam

Canadian Friends Spanish Friends of Rambam of Rambam RAMBAMHCC l 2017 ANNUAL REPORT

MAIMONIDES MAIMONIDES MAIMONIDES FRIENDSHIP LEADERSHIP GIFT CIRCLE CIRCLE CIRCLE

Donors who have made important and Donors who, through varying levels of Donors who have generously impactful contributions to dramatically commitment, have had a long-term given from their hearts for the improve Rambam’s services to the people impact on Rambam by supporting and support and advancement of of northern Israel. strengthening us in meeting our day-to-day Rambam. challenges.

43 MAIMONIDES GOLDEN CIRCLE

Amir, Herta and Paul

Barer, Meri and Sol J.

Beutler, Ernest and Bonnie

Buffett, Warren

Dankner, Nochi and Orly / D.I.C Loans/ IDB GROUP (2006)

Fishman, Joseph and Family

ISCAR

Israel Cancer Association (R.A)

Jewish Agency for Israel (JAFI)

Kaylie, Harvey and Gloria

Legacy Heritage Fund

Ofer, Eyal and Marilyn

Ofer, Sammy, Aviva and Family

Rappaport, Ruth, Bruce and Family

The Conference on Jewish Material Claims Against Germany

The Leona M. and Harry B. Helmsley Charitable Trust

The Wolfson Family Charitable Trust / The Wolfson Foundation

Weill, Joan and Sanford I. / The Weill Family Foundation

Wertheimer, Ariela and Eitan RAMBAMHCC l 2017 ANNUAL REPORT

MAIMONIDES FRIENDSHIP CIRCLE

A & M Green Foundation / Feldman, Moscona, Nissim Alberto / Goldie / Green, David and The A.M.N. Foundation Wagner, Daphne Nerken, Jean and Albert Adelson, Miriam and Sheldon Rostova, Mira Arieli-Goldschmidt, May, Paul Schreiber, Shoshana and Jacob and Louis Shore, Hy and Bertha/Shore, Barazani, Ovadia and Neil and Fred Greenberg, Marguerite Sim Lev Lalev Berg, Marsha and James Slutsky, Edward and Rebecca Crown Family Foundation Smolokowski, Slava, Isa and Family De Gutt, Tila Sohnis, Jonathan and Edna Dibner, Relly and Brent Spencer, Irma and Aaron Dotan, Varda and Boaz Stern, Leon Engel, Hedda and Yaakov Stichting Clara Mendes Forchheimer, Leo and Julia Stichting Levi Lassen Forman, Tatyana and Alan J. Strelitz, Arlene and Joseph Goldhar, Eli and Effi The Caroline and Joseph S. Gruss Gorman, Harry and Sara Life Monument Funds Hayim Association The D. Dan and Betty Kahn Foundation International Fellowship The David and Jacqueline Simon Family of Christians and Jews The Jewish Medical Colleagues Jampolsky, Marcel of Johannesburg Judah, Ivy The Leir Charitable Foundations Kahn, Guinter The Yaakov Meridor and Mila Brener Kusnetz, Samuel and Rose Foundation Laughton, Martin United Jewish Communities Levitt, Harry and Herman Weil, Emile and Marthe Marguerite Marienberg Family Women’s League for Israel Maurice Wohl Charitable Foundation Yad Avi Hayeshuv Meyer, Sally and Menashe Itzaak Yael Rambam Zukier Jacob and Gitla Medical Fund

45 MAIMONIDES LEADERSHIP CIRCLE

BENEFACTOR FOUNDER

Angel, Udi and Anat Keren Hayesod - Aharon Gutwirth Foundation Arazi, Pnina United Israel Appeal American Technion Society Ascoli, Maria Rossi Klakstein, Arye and Zipora Amir, Elka Bechor, David and Sofia Kornach, Michael Arison Group Benard, Maurice and Alice Lili Landsburg, Morris and Elizabeth Arnowitz, William and Janece Black, Scott Myles and Isabelle LeRoith, Derek Ashkenazi, Grazia Brecher, Susan Levine, Joe and Karen Askensi, Moris Cohen, Abby Joseph and David Levitus, May Atkind, Leo and Belle Combined Jewish Philanthropies Lewin, Clement and Susan Babush, Harry and Evelyn of Greater Boston Lulki, Mila Emilie Baron, Elza Dansac, Judith Renee Mayer, Mirel Barzilai, Nir and Laura Die Deutsche Ärztegemeinschaft MIS Implants Technologies Ltd. Bennett, Saidie and Maurice für medizinische Niego, Sammy and Malka Best Products Foundation Zusammenarbeit Ohebshalom, Fred Blank, Edward and Sharon Dream Doctors Ohebshalom, Nader Brachman, Malcolm Electric Company Palley, Rose Broder, Rose American Friends Workers’ Union - North Pariser, Paul S. Cedar, Zahava and Yoram of Rambam Elsbach, Hugo and Hertzdahl, Planet, Hagai Chais Family Foundation Australian Friends Carla Levina Rashi Foundation Cohen, Arnold L. and Barbara of Rambam Eretz Siamak Cultural Center Riner, Helga Lula Cohen, Ethel Fedan, Vladimir Roche Israel Cohen, Talma and Yuval British Friends Feist-Elzas, Ester Miriam (Erna) Rosenfeld, Ernesto and Ildiko Dalia and Eli Hurvitz of Rambam Feldenkreis, George A. and Schwartz, Aura and Moshe Foundation Ltd. Mariita Srebnick Sislin, Leno and Paul Danon, Joseph Canadian Friends of Rambam Frank, Albert and Patricia Staff of Rafael Ltd. Dansker, Norman and Gloria Gettenberg, Lynn W. and Gary S. Stier, Noam De Hart, Elvira French Friends Goldstein, Anna and Victor Strasberger, Joseph Denburg, Howard and Dorothy of Rambam Greidinger, Israel and Naomi Temple Shaaray Tefila Deutsch, Alex Greidinger, Moshe of Lawrence Diamond, Jesse Friends of Rambam Hershkovitz, Baruch The American Jewish Committee Diller, Dorothy in India Iranian American Jewish The Dr. Yaffa and Arie Shapiro Dozoretz, Ron Israeli Friends Federation of New York Research Fund Dragul, Paul H. of Rambam Israel Children’s Cancer Thirteen Synagogues of the Drucker, Zacharia Foundation- ICCF Shore Area Walk for Israel Ebin, Leonard and Eva Spanish Friends Israel Corporation Ltd. UJA-Federation of New York Edry, Rafi and Marina of Rambam Kahn, Michelle Wertheimer, Stef Emmerich, Adam O. and Pamela Katz, Avi White, Shelby and Levy, Leon Endtime Ministries Katz, Kalman and Sali Wolf, Rusinek Faraji, Ita RAMBAMHCC l 2017 ANNUAL REPORT

Feldman, Eliezer and Shulamit Krueger, Harvey M. and Connie Schreiber, Paul S. and Joan Feldman PE, Howard Larger Than Life Shulman, Neville and Emma Fondation Adelis Lasher, Moe and Charlotte Shulsky, Marvin R. and Linda Freeman, Brian and Harriet Lavenstein, Lance Silber, Rachel Fridman Reizin, Jorge and Lawson, Erica Simon Wiesenthal Center Rebecca Sinay Lazar, Rachel Smargon, Andrea Furman, Dave Leibel, Adela Sterling, David A. and Mona Gadenski, Yaakov Leon and Zipporah Goldstein Stock, Abe Geller, Bruno and Sofia Foundation Strauss, Andres Tomas Gerzberg Foundation Liebeskind, Arie L. and Doreen and Carolina Ginsberg, Albert Lipschik, Rochelle Temple Israel of Great Neck Glucker, Edna Haisman Mahoney, Cohen and Company The Colburn Family Foundation Gottesman, Arthur Marceli Meizles , Yosef and Berta The Friedberg Charitable Gould, Fredric and Helene Mendel, Pierre Foundation Great Neck Synagogue Mendelson, Alan C. and Agnes The Jewish Federation Green, Barry and Laurie Mesriani, Mersedeh and Ramin of Greater Los Angeles Green, Herbert and Joyce Meyer, Henry The Locker Foundation Grossman, Alan R. and Marjorie Neufeld, N. The Sobell Foundation Haber, Gal and Yael Neumann, Adam and Rebekah Vincent, Christian Haifa Foundation Operation Embrace Foundation Waldman, Ella Hermetic Trust (1975) Ltd. Operation Wheelchair Committee Waldman, Eyal Herschdoerfer, Aurelia Osama Engineering Ltd. Weichsel, Arturo Werner and Sigmund M. Oster, Abe and Ann and Veronica F. de Hochfeld, Henry Overseas Finance and Trading Westoff, Alexander and Clara Ilan, Eran Zvi (Geneva) Ltd. Yakubovich, Moshe Jablow, Robert and Carol Panamanian Jewish Community Youdim, Moussa and Fruma James Leon Dubrow Foundation Papavassiliou, Christakis P. Zilberblum, Feibel Jarndyce Foundation Paris, Stuart A. and Elaine Jesselson Foundation Picciotto, Renato Jewish Community Center Polo Ralph Lauren of San Francisco Portalo Holdings Inc. Jewish Federations Prostek, Sylvia of Canada - UIA Raviv, David JMF - Jeffrey Modell Foundation Reichmann, Susanne Kemp, Rose and Daniel Rosenberg, Malcolm Klakstein, Nir Ross Slater, Sabina Klein, David Rousso, Eli Korn, Henry H. and Ellen Schreiber, John J.

47 MAIMONIDES LEADERSHIP CIRCLE

PATRON

Abekasis, Avraham and Dorit Gonda, Tibor and Margot Shillman, Robert Abraham and Sonia Rochlin Greenberg, Alan and Family Shine, Barnett and Sylvia Foundation Hadassah The Women’s Zionist Shinold, Zeev and Bruria Abutbul, Michal and Daniel Organization of America Shipley, David and Dianna Agam, Jacob Hanna, Nabil and Gayda Sonnenfeld, Moti Anbarchi, Stella and Aliza Heyman, Ronnie F. and Sam Sporn, Victor and Noemi Association les amis de Ilin Industries Ltd. Stark, Helen l’hopital Rambam de Haifa Iranian Jewish Community Stoler, Michael Bakalarz, Edward and Tania of Los Angeles Strelitz, Robert Bakalarz, Ronald and Minna Jewish Center of Pelham Bay Striar, Daniel and Marlene Bank Hapoalim Kessler, Randall and Jan Tagar, Sarah Bank Leumi Kitamura, Zeni and Ryuji Tauber Nachemsohn, Carla Bar Yehuda, Moshe and Noa Kohen, Hanna The A. Alfred Taubman Ben Moshe, Sagi Kopel, Hani Foundation Beracha Foundation Lazaroff, Sophie The Carter Family of London Berger, Nancy Levitan, Oded The Naomi Prawer Kadar American Friends Braunstein, Harry P. and Joann Levy, Margite Foundation, Inc. of Rambam Broder, Abraham Lewin, Ben and Elizabeth The Nephrosis Research Australian Friends Carr, Daniel Lewin, Daniel Foundation of Rambam Chet, Meir and Rina LIBI Fund, France The Phileona Foundation Cohen, Menachem and Dvora Liebes, Alicia Union of Orthodox Jewish British Friends Dabakarov, Michael and Janna Maddahi, Jamshid and Angela Congregations of Rambam Deutsche Gesellschaft für Melamed, Jacob and Dorice Victorian B’nai Brith Parodontologie Melamed, Robert and Dalia Vilmush-Nirenberg, Ze’ev Canadian Friends of Rambam Doron, Yaffa and Arye Mizrahi, Margalit Wald, Roza and Koptce Dri, Yaacov and Miriam Nacht, Marius Wang, Carol J. French Friends Einziger, Moritz and Anita Newman, Erna and Bernard Wohl, Ruth and Harry of Rambam Eizenshtadt, Izabela Oreg, Hanna Wolff , Habar Emed, Yona and Alexander P.E.F Israel Endowment Fund Yechiely, Menachem Noah Friends of Rambam Emrani, Daniel Pictet and Cie Yekutiel Federman Fund in India Ernzweig, Netta and Herman Rose, David York, Myra and Joel Israeli Friends Eugen Jenoe Foundation Rothberg, Heidi Young Israel of Long Beach of Rambam Feig, Hadas and Ryan (Ze’ev) Rudman, Duke M.B. Zionism 2000 Feigenbaum, Marvin Sandler, Sam and Reba Zuckerman, Boris Spanish Friends Feigenbaum, Zev Zvi Schwartsman, Vladimir of Rambam Friedman, Cecilia (Chippy) Schwartz, Jesse and Carol Friedman, Roy Schwartz, Ruth Gabrel, Dora and Sidney Seitchik, Murray W. Goldstein, Henry (Heinach) Serz-Weinreb, Olga and Magda Shena, Rena RAMBAMHCC l 2017 ANNUAL REPORT MAIMONIDES GIFT CIRCLE

A.B.B. Technologies Ltd. Azrak, Victor Faradj B’nai B’rith Haifa Municipality A.C.S. Motion Control Ltd. B.S.T. Development and Bodak, Joseph Aarons, Cyril Construction Ltd. Boehringer Ingelheim Israel Ltd. Abbvie Biopharmaceuticals Ltd. Bagdadi, Nissim Bohrer, Abraham and Judith Abrahams, Gerald Bahá’í World Centre Bonnefont, Jean Adams, Jean Bakshtansky, Esther Born, Robert and Esther Adler, Leah Ballon, Milton Boston - Haifa Connection Agasi, Reuven and Polet Bar David, Aharon and Sarah Bouaziz, Guy and Renee Aharon, Zvi Eran Bar, Nava and Assaf Braunshtein and Abudi - Law Firm Aide Medicale Pour Israel Baran, Shlomo Brenner, Benjamin AIG Barer, Joshua and Sara Brenner, Tamar Akiba, Ruth Barnett, Gary (Gershon) and Ayala Bretler, Mariana and Max Aktionskomitee zur Betreuung Bashari, Haim and Rachamim Brodet, David israelischer Kriegsbeschädigter Bauer, Helene Brokman, Dani Allen, Harvey Beleson, Richard and Kim Brosh, Ya’acov (Cobie) Alon, Ruth Ben Chaim, Shlomo and Simona Brown, Solvejg and William Alper, Barry and Sarah Heller Ben Chamo, Itzchak Buffington, Richard and Sally Alpha Omega Foundation Ben Shoshan, Jacob Buhari, Muhammed Amin Altonin, Irina Ben Shushan, Rahamim (Ramo) Burstein, Adrian and Jacklin Amar, Samuel and Raymonde and Miri Burstin, Jack and Erna American Physicians Fellowship Benhorin, Nir Butnick, Milton and Dora Amgen Ben-Simon Aluminum Industries Ltd. Cahn Debre, Marianne and Sylvain Amiri Zichron Yaakov Ltd. Bercowitz, Sharon Cardozo, Irma Amster, Irene Berg, Yonatan and Sharon Carr, Cynthia Anna and Rachel Halperin Berkley, Fred and Sybil Carroll, John Foundation for Medical Research Berkowitz, Roger and Lynne Caspi Aviation Ltd. Anti Tuberculosis and Pulmonary Berman, Nathan and Liza Cass, Frank Diseases League Berry, Richard and Beverly Chais, Pamela and Stanley Apelson, Marilyn Beth Sholom Congregation, Cheshin, Yoel Aptowitzer Foundation for Haifa Lawrence, NY Clark-Dibner, Victoria Archie Sherman Charitable Trust Bibliowicz, Jacky Cleanetica Ltd. Argo Coral Maritime (Israel) Ltd. Bild Hilft e.V. Cohen, Amar Ariel, Liora Billet, Harry and Rookie Cohen, Annelise Arkin, Mori Biran, Yizchak and Ilana Cohen, Bruria and Yehuda Aroma Espresso Bar Birenbaum, Moshe and Malka Cohen, Elisha and Ayala Asher, Gilad Bitan Wines Ltd. Cohen, Guy Askin, Paula Bittan, Avi and Ziva Cohen, Omer and Shaked Adi Assis, Abraham and Saul Blachman, Arye Commercial del Panama Associated Hebrew Schools Blaichman, Frank and Cesia Community Synagogue Association des Francais Bloch, Sam and Lilly of Monsey Sisterhood Amis d’Israel Blond, Neville and Elaine Community Synagogue of Rye, NY Atmos Foundation Bloom, Beatrice Congregation B’nai Yeshurun, Auriat, Kerry Bloome, Mark and Sharon Teaneck, NJ Avigdor, Efrat Blum, Roberto Congregation Shaaray Tefila, NY Avital, Albert Blumberg, Hillary Congregation Shaarei Tsedek, Avon Finance Ltd. Blumenthal, David Curaco Ayer, Ariela Blumenthal, Lionel and Eva Contour Conventions and Tours Ltd. Azaz, Yaffa B’nai Brit Lishkat Zvulun Cutler, Natalie

49 MAIMONIDES GIFT CIRCLE

Cybergrants Inc. Feldman, Tzur Green, Adam and Dido Dabah Salah and Sons Ltd. Feldman, Ziel and Chaiki Green, Cary and Ronda Dagmi, Ezra and Hagar Fhima, Joel and Leah Green, Donna and Mike Sanderson Daily Rauch, Shulamit Fields, Kenneth and Sheila Green, Karen and George Fischer Daneshgar, Joseph and Shiva Fight Together Greenrock Charitable Trust Dankner, David and Aviva Finkelstein, Paul D. Gregory, Julia Dar, Shlomo Fishman, Joshua and Sima Gregory, Vera Dashe, Jodi Flash Lighting Blue and White Ltd. Grimberg, Efraim and Yehudit David, Joseph and Miriam Flora F. Morrell Charitable Trust Gross, Sarita K David, Sonny and Stella Fogel, Baruch Grossman, George Davidovitch, Abraham Foley, Michael and Theresa Gunn, Chan Dayan, Daryoush Forsmlingen, Judiska Gut, Ralph and Mary Dayyah, Imad Fox, Irving and Gloria Gutmann, Rachel Delman, Michael and Dafna Frankel, Sidney Guttman , David and Rita Delrahim, Vahid and Orna Franklin, Jonathan Haifa Rotary Club Derfeld, Maria Freemasons Israel Halperin, Yosefa Deutsch-Israelische Hilfe für Friedman, Bradley Halpern, Sam krebskranke Kinder Friedman, Chaim Hamdan, Yoosuf Turki Devidas, Moshe and Rivka Friends of Israel Cancer Hansje Sillevis Foundation Dexcel Pharma Association Munich Harel, Assaf American Friends Diab, Adnan and Iman Friler, Liliane Harvest, Michaela of Rambam Diamond, Marc J. and Elizabeth Gabai, Eran Hauseman, Omri and Sivan Dibner, David and Frances Galdi, Vince Hayek, Rabea Australian Friends Divident Ltd. Galil, Uzia and Ella Heinsohn, Patricia of Rambam Dochi, Muhamad Gavrieli, Edna Hekkert, Shalom Dover, Bertie and Barbara Gertman, Tova and Tomy Hekmat, Farshid and Farah British Friends Dr. Jakov Isler Foundation Gildor, Adi Sivan Heller, Roma of Rambam Drake, Jack and Linda Gindi, Rachel Henka and Moshe (Mahala Drazner, Michael and Carmela Ginzburg , Ella Masari) Rave Foundation Canadian Friends Dreyfus, Leora Eigar GlaxoSmithCline’s (Israel) Ltd. Herczeg, Agnes and George of Rambam Driancourt and Cie (D and Cie) Gluck, Izabella Herzel Grinshpon - Investments Ltd. E.C.Y. Light Ltd. Gokovski, Hava Hirsch, Shmuel and Geula French Friends Edrei, Fannie Golan, Edna Hitter, Yoli Noe of Rambam Electra Consumer Products (1970) Ltd. Goldfarb, Barbara Black Hochberg Family Elmalech, Rina Tali and David Goldman, Norman and Diana Hochstein, Michael and Suzanne Friends of Rambam Emerald Worldwide Corporation Goldman, Richard and Rhoda Hod HaCarmel Rotary Club in India Eortc Brain Tumor Group Goldman Sachs Gives Hod, Ofir Eskenazi, Alberto and Efraim Goldstein, Dror and Dovrat Hoffman, Ron and Heather Israeli Friends Ester and Abbe Kurlands Mindefond Goldstein, Israel and Froma Hojman, Alberto of Rambam Eurcom Marketing (1986) Ltd. Goldstein, Ramy and Smadar Hood, Rodney E. Eyal, Amir Gordon, Mark J. and Ana Maria Houllou, Albert and Naomi Spanish Friends Falach, Maher Goren, Inbal Lilach Hubert, Emmi of Rambam Falic Family Foundation Goren, Yossi Ilex Medical Ltd. Farahi, Jila Gorman, Earl and Loren Lieberman Immanuel College Fattal, William Gorodisch, Irene Kulish In His Image Foundation Feingold, Tomer and Iris Gottlieb Fischer, Leo and Eva Ingerman, Elliott and Linda Feinstein, Leonard and Susan Gottlieb, Arie Ingerman, Ira Feit, Eran and Nicole Grant, Warren and Randi Iranian American Jewish Cultural RAMBAMHCC l 2017 ANNUAL REPORT

Organization (IAJCO) Khaleghi, Karen Libovner Voliner Benevolent Society Ironi A School, Haifa Khazani, Simon Lichtenstein, Steve Isak Gimple, Salmon Khobian, Jacob Lichtman, Marshall and Alice Jo Isracard Khodosh, Roman and Popovic, Sophia Lief Family Charitable Fund Israel Discount Bank Ltd. Kibbutz Dalia Linial, Shimon and Rivka Israeli Medical Association Kibbutz Maabarot Liron, Nadav and Ruth Isselbacher, Rachel Kibbutz Yagur Litany, Sara Itzkovitzi, Shalom Klatskin, Charles and Lynne Livnat, Moshe J.C. Health Care Ltd. Klein, John and Miriam Loden, Elliot H. Jacobson, Mitchell and Kathy Kogan, Chaim Lorya, David and Sheli Jaglom, Elchanan Amiel Kogan, Israel Louis, Sandzer Jennings, John Kohav, Itzhak Louna, Joseph and Matilde Jerichower , Gertrude Debora Kolinsky, Martin Luchins, David Jewish Child’s Day Korenvaes, Harlan and Amy Lustman, Felix Jewish Communal Fund NY Korzom, Elham LycoRed Natural Products Jewish Community Endowment Fund Kotowitz, Harry Industries Ltd. Jewish Community Foundation of Krasnoslesky, Alexey and Galina Magen LaCholeh Los Angeles Kraut, Michael and Naomi Magen, Vered Jewish Community of Greater Stowe Kropveld , Erna Elsina Jacqueline Magid, Abe and Sally Jewish Federation of Greater Kross, Marc Magid, Harold and Rhonda Los Angeles Krupp, George Magid, Larry and Millie Jewish Federation of Palm Springs Kuperwaser, Mark and Judith Mandles, Martin and Connie and Desert Area Kutner Showel, Dora and Morris Maramoresher Society Jewish Federation of Ventura County Lamroth Hakol Marateck , Samuel Joles, Harold Lapsker, Joshua Marchant, Debra Jourdan, Michael M. and Iris Laufer, Gerta Marcus, Paza and Dror Jura, Eugene Laufer, Shlomo and Miriam Margules, Herman and Ruth Kahn, Nelly M. Lavi, Eliaz and Osnat Marina Galilee Mushrooms Ltd. Kalifer, Ron and Nancy Lavon, Benjamin and Dalia Mark and Anna Ruth Hasten Kalisman, Amir and Ra’aya Le Comite de Souiten Amit Family Foundation Kalisman, Michael and Gayle Abramson Markel, Shlomo and Ariel Kamhi, Sami and Aiva Leeds Jewish Ex Servicemen and Marmelzat , Williard L. Kamor Ltd. Women Association Marram, Edward Kanis, Yana Lehman Brothers Investment Bank Marvel Semiconductor Israel Ltd. Karasick, Mark Lehman, Bill and Sandra Mashash, David and Dolly Karlin, Baruch and Amira Leibovitz, Yosef Mashav Initiation and Kasner, Joseph Leictman, Dimitri Development Ltd. Katan, Sylvia Leo Baeck School, Haifa Mason, Peter and Mary Katz, Frances R. Leon Judah Blackmore Foundation Matan - Investing in the Community Kavodi, Rutie and Admon Leuberski, Nilli Mayer, Etti and Leon Kazaz, Haim Lev, Rami and Nira Mayer, Itzack and Tzofiya Keen, Mark Levin, Liran Mederen Neotech Ltd. Keesing, Aleida Levinger, Dedi Mendel, Yoseph and Rachel Keliah Levy, Guy Mendelbaum, Salo and Merav Kemp, Evie and Simon Fineman Levy, Jebb and Donna Mesriani, Rodney Keren Meromim Levy, Yosef and Pnina Mesznik, Eugenie Geula Keshet Teamin Ltd. Lewis, Jeffrey Mesznik, Eytan and Shelley Kessler, Howard Lewis, Stanley A. Mesznik, Joel and Lynne

51 MAIMONIDES GIFT CIRCLE

Mesznik, Roger and Summers, Lynn Pasadena Community Foundation Rothenberg, Robert P. and Helene Midav Chemicals Trade Ltd. Pasternak, Eli and Carmela Rowe, Jacob MIFF Oslo Peletz, Pesia and Abraham Ruben, Dennis and Joyce Migdal Insurance Company Ltd Perl, Berndt and Gail Rubin, Jami and Reiff, Eric Milbert, Simon Perlshtein, Dror and Ester Rubinstein, Yoav Miller, Alan B. and Jill Perry, Lily and Morris Ruksan Investments Ltd. Miller, Antonia Pharmaexcel Ltd. Rustin, Charles Minden Management Ltd. Phillips, Rachel Sachs, Benjamin P. Mintz, Rivka and David Piso, Amram Salama, Walid Mir, Farid Pizan, Alf Samuel and Ethel Lefrak Trust Mir, Paul Youssef and Karmela Pizan, Sidney Samuels, John Moghaddam, Bahram Platnick, Geoffrey and Tobi Printz Sarbani, Erna and Naftali Moghavem, Abdullah Alex Polakoff, Dale Sarfati, Shimon and Mahroo Pomeranc, Jack and Sally Sarshar, Masud Moradi, Isaac and Jacqueline Porat, Yigal and Zehava Sasson, Joseph Morsel, Charles Port, Irving and Sally Savacool, Cecil Morsel, Issy Portsmouth Jewish Ladies Savion Industries (1987) Ltd. Moshkovitz, Pnina and Yossi Benevolent Society Sayage, Michael Mutai, Eli Providental Finance Inc. Schechter, Robert Namvar, Sean Purple Cow Ltd. Schipper, Lionel and Carol American Friends Namvar, Tony Putsman, Maurice Schon, Lew Charles of Rambam Nash Family Foundation Quitman Lecturship Schusterman Foundation-Israel Nazareth United Bus Services Ltd. Rabin, Yuval Schwab Charitable Fund Australian Friends Neibart, Steven and Kathleen Rappaport, Yehoshua and Carmela Seginer, Ido of Rambam Neman, Yoel and Sherry Rauch, Leah Mory Seiden, Norman and Barbara Neopharm (Israel) 1996 Ltd. Rauch, Uzi Sela, Ilan British Friends Netivei Bar (2005) Ltd. Ravael, Ramin Sela, Tuvia of Rambam New Lineo Cinema (2006) Ltd. Ravon Electronics Ltd. Seymour J. Abrams Family New West End Synagogue Raz, Amir Foundation Canadian Friends Newman, Wendy Reali Hebrew School Shahery, Shahrokh and Shirin of Rambam Nia, Mina Redlor, Ruth Shalmiev, Grisha Nilit Ltd Registration Fees Shapira, Hanna French Friends Nimri, Ari Rekah Foundation Shapira, Rachel and Robbie of Rambam Nirenberg, Wilmesh Reuben, Mordechay Shavitzky Management (2012) Ltd. Normand, Relly Richman, Rick and Judy Shefa Concession Ltd. Friends of Rambam Novack, Kenneth J. Rikover, Oded Sheingut H.M. Ltd. in India Novartis Pharma Services AG Robert Russell Memorial Shen Orr, Chaim and Tzila Novo Nordisk Ltd. Foundation Sherball and Denman Israeli Friends Nusbaum, Avshalom Rodaler SA Charitable Fund of Rambam Ofakim Travel and Congresses Ltd. Rommer, Hanka and Simon Shilkrut, Mark Ofer Aviation Ltd. Ronal, Shoshana and Shalom Shitrit, Meir and Ruth Spanish Friends Olemberg, Isaac Ronne and Donald Hess Foundation Shmeltzer, Shlomo and Atalia of Rambam Oren, Yehudit Rose Agriculture Ltd. Shmuel, Zohar Osada (1998) Ltd. Rose, Jeremy Shmuelvitz, Yifat Oscar Gruss and Son Rosengard, Bruce R. and Ariella Shnier, Carole Ovadia, Mordechai Rosetree Trust Shochat, Hannah Pakravan, Danny Rositzky, Doron Shochat, Liora Pano Center Rotenier, Richard Shomer, Paula RAMBAMHCC l 2017 ANNUAL REPORT

Shoval - Engineering and Roslyn Heights Organization Association of Construction Tenenbaum, Marty and Bonnie Winograd Shreiber, Rivka and Naftali Teubal, Diego and Bettina Visner, Tova Shtokman, Israel Teva Pharmaceutical Industries Ltd. Wasser, Walter Shuarma Hazan (Ford) Ltd. The Azrieli Foundation Canada Wax, Robert and Sara Shulman, Gerald The Bank Leumi Trust Company Ltd. Wayne and Marilyn Mason Sidney Frank Foundation The Boxenbaum-Netta Charitable Fund Silverman, Joel and Nira Foundation Ltd. Weinberger, Barry Simon, Harold The David Berg Foundation, Inc. Weisman, Harlan F. Simons, Charles The Doctors’ Committee at the Wiesler Family Foundation Sinai Temple Los Angeles Rambam Health Care Campus Wiesler, Mordechai and Michal Singer, Daphne The Families of Joel York and Wilsker, Mark Sizemore, Marlene E. Michael Lax Wizner Family Skolnick, Alex and Hannah The Harry and Jeanette Weinberg Wizner, Eyal and Shira Skolnick, Howard Foundation, Inc. Wolf, Dora Sloane, Marshall The Henry and Marilyn Taub Woodside Park Synagogue Sminski, Michael Foundation Yad Hanadiv Snir, Edward and Ronit The Israeli Society of Yadidi, Camron Soffer, Shaul and Yehudit Rheumatology Yadidi, Kambiz Solomon Schechter Day School The Jack Chester Foundation Yahel Foundation in Memory of of Greater Boston The June Baumgardner Gelbart Yehuda Leon Recanati Solomon, David and Mary Foundation Yakov, Davidah Southend and Westcliff The Lewis Family Charitable Trust Yediot Tikshoret Hebrew Congregation The Mendelson Family Foundation Yesh Tikva Srouji, Kameel The Nussia and Andre Aisenstadt Yonah, Sasson and Dorit Staransky, Alexander and Klara Foundation Yosephberg, Mina Stefan Adelipour For Life The Parodontologist Jewish Zafran, Anna Foundation Association Zairi, Ido and Jennifer Stein, Yonah and Yehuda The Russell Berrie Foundation Zarco, Robert Stern Ceramics The Samson Israel Charitable Trust Zeleznick, Ina and Lowell Storage Leaseholds Inc. Times of Israel Zigdon, Hadar Stowe, Marilyn Toledano, Jacques Zilberman, Yakov and Dina Sultoon, Babette Torel, Albert Zimberg, Morton Summers-Kurzer, Beverlie Tramiel, Sam and Tzipora Zimmerman, Martha and David Vincent Trau, Solomon and Beryl Zionist House Inc. Super-Pharm Ltd. Troy, Gil Zubidat, Rifat Suppree, Isidore D.L. Truist Swaid, Swaid Truman, Carole Swartz, Sosan Tsityat, Dalya Tadmor, Ze’ev and Zipora Tzuckerman, Dina and Meir Taha Arabia Ltd. Udi, Oded Dor Tal-Mir Electronics Ltd. United Israel Appeal of Canada Inc. Talmon, Yehuda United Synagogue Youth

Tanner, Harold and Nicki Variety Israel Our apologies if we have TD Ameritrade Clearing Verbov, Hazel and Julian omitted your name or erred in Technion - Israel Institute Vigdor, Eliyahu Edgar the listing. Please let us know so we can be sure to correct of Technology Villar International Ltd. any oversight: Temple Beth Sholom, Vineyards Charity by the [email protected]

53 RAMBAM BOARDS

RAMBAM HEALTH CARE CAMPUS SCIENTIFIC BOARD OF TRUSTEES ADVISORY BOARD

Eitan Wertheimer Professor Howard (Chaim) Cedar Chairman Chair, Israel

Udi Angel Eyal Ofer Professor Eugene Braunwald, USA Joseph Ciechanover Idan Ofer Professor Irun Cohen, Israel Zvi Eisikovits Ruth Rappaport Professor Scott Friedman,USA Moti Fishman Irit Rappaport Professor Hedvig Hricak, USA Levy Gerzberg Moshe Revach Professor Jacob Sznajder, USA Dani Goldman Ariela Wertheimer Sari Gredinger Yona Yahav Professor Aaron Ciechanover Peretz Lavie Chair Emeritus, Israel RAMBAMHCC l 2017 ANNUAL REPORT

FRIENDS OF RAMBAM BOARDS OF DIRECTORS

AMERICAN Zahava Cedar Tammy Koniarski FRENCH ISRAELI FRIENDS Relly Dibner Events and Catering FRIENDS FRIENDS OF RAMBAM George A. Feldenkreis OF RAMBAM OF RAMBAM Alan Forman Pnina Gal Adam O. Emmerich Levy Gerzberg Ella Gorenstein Joelle Abitbol Israel Greidinger President Frances R. Katz Alex Levron President Chairman Alan C. Mendelson Dr. Margot Sims Harvey M. Krueger Jesse M. Schwartz Avi Strajt Yaelle Gamon Taieb Galit Rothschild Vice President Jonathan Sohnis Treasurer Executive Director Aaron D. Spencer David A. Sterling Irma Spencer BRITISH Dr. Yvan Coscas Nir Gilboa Secretary and Treasurer FRIENDS Ronen Ginzberg OF RAMBAM Professor Haim Meri Barer AUSTRALIAN FRIENDS OF Hammerman Executive Committee FRIENDS Anita Alexander-Passe RAMBAM Shaviv Israeli OF RAMBAM Director IN INDIA Arik Levanoni Richard S. Hirschhaut Yitzhak Mitrani National Executive Vered Harel Gabriella Alexander- Rajen Pravinchandra Director Director Passe Shah Treasurer President SPANISH Sari Katz Arshadnia Martie Abraham FRIENDS Director, Western Region Vice Director Samantha Louise Rose Narendra Prakashchand OF RAMBAM Trustee Bansal Ellen S. Pomerantz Rachel Engelman Vice President Robert Stern Director, Northeast Secretary President Region CANADIAN Ralphy Ezekiel Jhirad Hagar Lipa FRIENDS Co-Chair & Dr. Edmundo Jillian Jacobs Treasurer OF RAMBAM Secretary General Berros Elbaz Executive Assistant Vice President Ariel Cohen David Green Yael Jhirad Nathaniel Goldman Solicitor President Co-Chair and Treasurer Viorica Stern Director of Finance Amanda Karen Gipson and Operations Ronen Atzmon Kelly Wright Shilpa Shah Asunción Ríos Rey Solicitor Administrative Assistant Professor Lael-Anson Best Susan Baron Director, Southeast Aron Merar Kerry Auriat Region Promotion and Earl Gorman Chairperson Ron Kalifer David M. Adlerstein Marlene Katz Perry Wong General Counsel Community Engagement

Yair Kagan Noam Rozen Executive Vice President Business Relationship Emeritus

55 RAMBAM MEDICAL LEADERSHIP CIRCLE

The executive leadership of Rambam Health Care Campus honors and pays tribute to its physicians and surgeons who have made landmark contributions to the development of clinical medicine, the advancement of medical research, to the education of future generations of medical leaders both within the medical center and beyond, and who thereby serve as examples of outstanding leadership in their field.

L-R: Prof. David Ehrlich, Bruce Rappaport, Sir Evelyn de Rothschild at the groundbreaking ceremony for the Rappaport Faculty of Medicine of the Technion-Israel Institute of Technology RAMBAMHCC l 2017 ANNUAL REPORT

PROFESSOR ORNAN (ORI) BETTER

Established the first department of Nephrology at Rambam Medical Center, with facilities for dialysis and kidney transplantation. Developed the protocol PROFESSOR DAVID EHRLICH for the treatment of Crush Syndrome, which has been universally adopted and One of the founding fathers of Israeli used throughout the world to this day. surgery and a pioneer of kidney transplantation. Initiated and founded SERVED AT RAMBAM FROM 1959 - 1993 the Technion’s Ruth and Bruce Rappaport Faculty of Medicine and served as its first Dean. Awarded the Israel Prize in Medicine, 1992.

SERVED AT RAMBAM FROM 1948 - 1977

57 RAMBAM LEADERSHIP 2017

Rafi Beyar, MD, DSc General Director and CEO

Shimon Reisner, MD Deputy Director until 30.4.2017

Karl Skorecki, MD Director, Medical and Research Development

Esther Golan, PhD Managing Director of International Relations and Chief of Strategic Development

Michael Halberthal, MD Deputy Director

Avi Weissman, MD Deputy DirectorRAMBAM Michal Mekel, MD Deputy Director

Nissim Haim, LLM Deputy Director (C.O.O.)

Gila Hyams, RN, MA Director of Nursing

Ronit Segal Hirshberg, PhD CEO, Rambam Health Corporation and Director, Department of LEADERSHIPEconomics and Marketing Ariye Berkoviz, MBA Director, Department of Engineering, Rambam Health Corporation

Amir Waiman, MBA, CPA Director, Division of United Finance

Sara Tzafrir, BSc, MA Chief Information Officer

Nora Libes Shnaid, BSc, MBA Director, Department of Economics & Business Development

Ziv Sharon, MA Treasurer

Lior Lowenstein, MD Director, Medical Operations

Myriam Ben-Arush, MD Director, Pediatric Division, Ruth Rappaport Children’s Hospital RAMBAMHCC l 2017 ANNUAL REPORT

Yehuda Chowers, MD Director, Clinical Research Institute at Rambam (CRIR)

Ehud Klein, MD Director, Division of Research

Ora Israel, MD Director, Nuclear Medicine

Doron Norman, MD Director, Division of Surgery

Benjamin Brenner, MD Director, Division of Internal Medicine

Eyal Fruchter, MD Director, Division of Psychiatry

Zeev Weiner, MD Director, Division of Gynecology and Obstetric

Itzhak Beiran, MD RAMBAMDirector, Ambulatory Care Leon Levi, MD Assistant to the General Director; Director, Medical Administration Unit

Fuad Basis, MD Deputy Director, Medical and Research Development; Director, Accreditation Project

Ronit Almog, MD Director, Epidemiology Unit LEADERSHIPand Biobank Tal Asaf Moskovich, Adv Director, Medical Claims Quality and Safety

Michal Paul, MD Director, Infectious Diseases Institute

Khetam Hussein, MD Director, Infection Control Service

Talia Berman-Kishony, Adv Director, Service Quality 2017and Patient Relation David Ratner, MA External Relations & Spokesperson

Zahava Talmor, MA Assistant to the General Director

Oded Mayer, BA Director, Marketing Department

59 NEW APPOINTMENTS 2017

Rambam HCC Director, Professor Rafi Beyar greets newly appointed directors

2nd row, r-l: 1st row, l-r:

Ronit Beck-Fruchter, MD, Ram Weiss, MD, Director, IVF Unit Director Department of Obstetrics and Gynecology Department of Pediatrics Ruth Rappaport Children’s Hospital Uri Paz, MD, Director, Endoscopy Unit Ayelet Eran, MD, Department of Obstetrics and Gynecology Director Neuroradiology Unit and Magnetic Resonance Morir Khamaisi, MD, Imaging (MRI) Institute Director Department of Internal Medicine D Avi Weissman, MD, Deputy Director, Rambam HCC Eitan Abergel, MD, Director Rafi Beyar, MD, DSc, Invasive Neuroradiology Unit Director, Rambam HCC

Elizabeth Half, MD, Luda Guralnik, MD, Director Director, CT Unit Gastrointestinal Cancer Prevention Unit Medical Imaging Department

Avivit Peer, MD, Vardit Gepstein, MD, Director, Clinical Trials Unit Director, Ambulatory Pediatric Unit Oncology Division RAMBAMHCC l 2017 ANNUAL REPORT

RAMBAM HCC RESEARCH CAREER DEVELOPMENT These and other related programs rely on the philanthropy of individuals and foundations PROGRAMS who want to leave their mark on future generations through medical advancements facilitated by biomedical and clinical research.

THE FUTURE PROGRAM THE GUARDIAN PROGRAM (Formerly known as Atidim) RESEARCH & INNOVATIVE PRACTICE BASIC AND TRANSLATIONAL RESEARCH NURSING GRANTS GRANTS FOR RESIDENTS Gleb Sakharov, RN, MA Naara Shorook, MD Hematology and Bone Marrow Department of Otolaryngology Head Transplantation Section and Neck Surgery Ahlam Hijaze, RN Shadi Safuri, MD Department of Pediatric B Department of Ophthalmology Miri Katz, RN, MA Department of Dermatology THE HORIZONS PROGRAM (Formerly known as Ofakim) Pazit Gelber, RN, MA and Adnan Halil, RN Operating Room Division

BASIC AND TRANSLATIONAL RESEARCH Shoshana Mordechaiev, RN GRANTS FOR YOUNG SENIOR Gastroenterology Institute PHYSICIANS

Haggai Bar-Yoseph, MD THE SPARK PROGRAM Gastroenterology Institute (Formerly known as Nitzoz)

Michal Cohen, MD PROTOTYPES, FEASIBILITY, AND IP Department of Pediatric A PROTECTION FOR MEDICAL INNOVATIONS

Mauricio Cohen Vaizer, MD Department of Otolaryngology Head and Neck Surgery

61 The Rambam Award honors individuals of 2017 extraordinary vision whose major contributions to medicine, technology, and humanity RAMBAM are improving the well-being of countless AWARD individuals in Israel and around the world.

LAUREATES

AMBASSADOR DENNIS B. ROSS, USA PROFESSOR RICHARD HORTON, UK PROFESSOR JEFFREY M. DRAZEN, USA HARVEY AND GLORIA KAYLIE, USA

L-R: Professor Richard Horton, Alicia Kaylie, Professor Rafi Beyar, Ambassador Dennis B. Ross, Professor Jeffrey M. Drazen, Professor Karl Skorecki RAMBAMHCC l 2017 ANNUAL REPORT

COMMITTEE PREVIOUS RECIPIENTS

Professor Rafi Beyar 2016 Director and CEO, Rambam HCC Professor Emeritus William R. Brody Professor Eric J. Topol Professor Karl Skorecki Mr. Sandor Frankel and The Leona M. and Director of Medical and Research Harry B. Helmsley Charitable Trust Development, Rambam HCC 2015 Mr. Shimon Peres, of blessed memory Israel Greidinger Rabbi Lord Jonathan Sacks Chairman, Israeli Friends Mr. Eyal Ofer of Rambam Ms. Mariita and Mr. George Feldenkreis Professor Mary-Claire King

2014 Mrs. Herta and Mr. Paul Amir Ms. Relly and Mr. Brent Dibner Professor Howard (Chaim) Cedar Mr. Yona Yahav

2013 Mr. David Green Dr. Sol J. Barer and Mrs. Meri Barer

2012 Professor Richard L. Popp Rabbi Yechiel Eckstein Ms. Joan H. and Mr. Sanford I. Weill

2011 Mr. Harvey Krueger, of blessed memory Mrs. Gila Almagor Agmon Mr. Nochi Dankner Dr. Donna E. Shalala The Hon. Mrs. Laura Wolfson Townsley Mr. Joseph Fishman, of blessed memory / The Fishman Family

2010 Mrs. Ruth Rappaport of blessed memory Mr. Sammy Ofer of blessed memory Rabbi Elimelech Firer Professor Moshe Revach

63 HONOR ROLL 2017 AWARDS FOR SCIENTIFIC ACHIEVEMENT

Rambam is honored to administer two prestigious nationwide medical research programs. Both programs are open only to israelis and contribute to Israel and Rambam’s renown in promoting excellence in research.

THE YOUDIM FAMILY PRIZE FOR THE ERNEST AND BONNIE BEUTLER EXCELLENCE IN CANCER RESEARCH RESEARCH PROGRAM OF EXCELLENCE IN GENOMIC MEDICINE The Youdim Family Prize for Excellence in Cancer Research was established by The Ernest and Bonnie Technion Professor Emeritus, Moussa Youdim, Beutler Research Program to support cancer research exemplified of Excellence in Genomic by excellence, novelty, and/or scientific Medicine was established breakthroughs. by Bonnie Beutler to honor the memory and work of The Youdim Prize awardee will be chosen her late husband, Dr. Ernest in 2018. Beutler. This program supports high level genomic research projects of Israeli investigators.

2017 AWARDEE

Professor Roy Kishony Faculty of Biology, Technion Research title: Predicting Antibiotic Resistance and Treatment Failure in Urinary Tract Infections RAMBAMHCC l 2017 ANNUAL REPORT 2017 COMPETITIVE GRANTS

Boehringer Ingelheim Co (BI) Israel Cancer Research National Institutes of Health (NIH) Dr. Oren Caspi Foundation (ICRF) Prof. Michal Paul Cardiology Section Prof. Ziv Gil Infectious Diseases Unit Department of Otolaryngology David Lynch Foundation Head and Neck Surgery National Institute of Psychobiology Prof. Eyal Fruchter in Israel Division of Mental Health Dr. Neta Milman Prof. Eyal Fruchter Department of Otolaryngology Division of Mental Health D-CURE Head and Neck Surgery Dr. Michal Cohen Roche Pharmaceuticals Pediatric Endocrinology Unit Israel Gastroenterology Dr. Daniel Kurnick Association Clinical Pharmacology Unit EU Dr. Itay Maza Prof. Michal Paul Gastroenterology Institute Dr. Ayal Rozenberg Infectious Diseases Unit Department of Neurology Israel Innovation Authority Gassner Fund for Medical Dr. Yaron Bar-Lavie The Israel National Institute Research Division of Critical Care for Health Policy Research Prof. Michal Paul Prof. Michal Paul (in collaboration Infectious Diseases Unit Prof. Lior Gepstein with Rabin Medical Center) Cardiology Section Infectious Diseases Unit German-Israeli Foundation (GIF) Dr. Yuval Gefen Dr. Ruth Perets Prof. Ziv Gil Microbiology Laboratory Division of Oncology Department of Otolaryngology Head and Neck Surgery International Atomic Energy Israel Science Foundation (ISF) Agency Dr. Sara Selig Prof. Ziv Gil (in collaboration with Prof. Ora Israel Nephrology Institute University of Haifa) Nuclear Medicine Institute Department of Otolaryngology Dr. Yelena Granovsky Head and Neck Surgery Israel Cancer Association (ICA) Department of Neurology Dr. Itay Maza Prof. Tzvi Dwolatzky (in collaboration Gastroenterology Institute Prof. Mogher Khamaisi with University of Haifa) Institute of Endocrinology, Diabetes Geriatric Services Dr. Moran Amit and Metabolism Department of Otolaryngology The Israeli Society of Nephrology Head and Neck Surgery Israel Society for Clinical and Hypertension Oncology and Radiotherapy Dr. Suheir Assady Dr. Oz Mordechai Dr. Talia Shentzer Kutiel Department of Nephrology Department of Pediatric Oncology Division of Oncology and Hematology The Leona M. and Harry B. Helmsley Materna Industries Charitable Trust Dr. Fahed Hakim Dr. Liron Borenstein-Levin Prof. Yehuda Chowers Pediatric Pulmonary Unit Neonatal Intensive Care Unit Gastroenterology Institute

Dr. Shlomit Strulov Shachar Ministry of Science The Naomi Foundation Division of Oncology Prof. Michal Paul Dr. Ruth Perets Infectious Diseases Unit Division of Oncology Dr.Shorook Naara Department of Otolaryngology Dr. Hiba Yaseen XLEAR Inc. Head and Neck Surgery Clinical Research Institute Dr. Arie Gordin Department of Otolaryngology Dr. Shlomit Yehudai-Reshef Prof. Naim Shehadeh Head and Neck Surgery Hematology and Bone Marrow Institute of Endocrinology, Diabetes Transplantation Section and Metabolism

Dr. Ruth Perets Division of Oncology

65 FISCAL OVERVIEW

STATEMENT OF ACTIVITIES (in millions of shekels)

INCOME: 2017 2016*

Medical services rendered 1,609 1,504 Research projects 43 42 Other 19 20 TOTAL 1,671 1,566

ALLOCATIONS:

Building, construction and renovation 39 36 Medical equipment 20 21 Computerized equipment 6 5 Other equipment and supplies 5 6 TOTAL 70 68

EXPENSES:

Salaries 1,173 1,115 Medical and technical equipment 236 247 Maintenance 92 90 Operating expenses 201 175 General administrative expenses 90 94 TOTAL 1,792 1,721

Full reports are available upon request.

*Recalculated

DONORS DONATIONS 2017

870 $16M USD Total Total Number Amount of Donors Raised

$12,600 USD 21 Average 440 Donation COUNTRIES New Donors 2012-2017 RAMBAMHCC l 2017 ANNUAL REPORT

PATIENT CARE

PATIENT CARE 2017 2016

ANNUAL ADMISSIONS 92,448 93,541

TOTAL PATIENT DAYS 357,228 355,453

EMERGENCY DEPARTMENT VISITS 142,940 138,102

OUTPATIENT VISITS 726,279 699,161

TOTAL PATIENTS TREATED 260,139 254,894

IMAGING PROCEDURES 275,867 272,616

LABORATORY EXAMS 12,626,015 12,667,852

SURGICAL PROCEDURES 58,604 57,789

DELIVERIES 5,012 5,114

AVERAGE OCCUPANCY 96% 95%

HOSPITALIZATIONS BY AGE

14%

7% 92,448 HOSPITALIZATIONS IN 2017 57%

22%

0-10 yrs 11-20 yrs 21-70 yrs +70 yrs

RESEARCH 2017 2016

NEW RESEARCH 423 441

ACTIVE RESEARCH 1,650 1,626

67 EMPLOYEES & CAPACITY

EMPLOYEES BY SECTOR OVERALL CAPACITY

HOUSEHOLD & HOSPITAL BEDS 962 ADMINISTRATION MEDICAL INSTITUTES 39 PHYSICIANS 1,255 1,192 INPATIENT WARDS 57

23% 24% SPECIALIZATION UNITS 73 OUTPATIENT CLINICS 113 5,150 EMPLOYEES ALLIED HEALTH 20% 1,037 32%

NURSES 1,666

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