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Facilitators What’s On Your Mind? FACILITATORS Facilitator in Chief and Founding Facilitator Richard J. Barohn, M.D., Executive Vice Chancellor for Health Affairs, University of Missouri and Distinguished Emeritus Professor, University of Kansas Medical Center Associate Chief Facilitators Yuebing Li, M.D., Staff Neurologist, Neuromuscular Center, the Cleveland Clinic Foundation Michael T. Pulley, M.D. Ph.D., Associate Professor of Neurology and Director, EMG Laboratory, University of Florida, Jacksonville Managing Editor Facilitators Jiji Oufattole, University of Missouri Breanna Tuhlei, University of Missouri Board of Facilitators William Campbell, M.D., Professor Emeritus, Department of Neurology, Uniformed Services University Mazen Dimachkie, M.D. Professor of Neurology & Director of Neuromuscular Division, Executive Vice Chairman & Vice Chairman for Research, Dept. of Neurology University of Kansas Medical Center Erik Ensrud, M.D., Associate Professor of Orthopaedics and Rehabilitation, Oregon Health & Science University School of Medicine Raghav Govindarajan, M.D., Assistant Professor of Neurology, University of Missouri School of Medicine Laura Herbelin, EMG Technician and Research Instructor (ret), Neurology , University of Kansas Medical Center Jonathan S. Katz, M.D., Director, The Forbes Norris MDA/ALS Research and Treatment Center John Kissel, M.D., Chair of Neurology(ret.), Ohio State University Wexner Medical Center Todd Levine, M.D., Medical Director, HonorHealth Neuroscience Institute Yuebing Li, M.D., Staff Neurologist, Neuromuscular Center, the Cleveland Clinic Foundation Georgios Manousakis, M.D., Assistant Professor of Neurology, University of Minnesota Tahseen Mozaffar, M.D., Director, UC Irvine-MDA ALS and Neuromuscular Center, Neurology School of Medicine Mamatha Pasnoor, M.D. Associate Professor, Dept. of Neurology, University of Kansas Medical Center Michael T. Pulley, M.D. Ph.D., Associate Professor of Neurology and Director, EMG Laboratory, University of Florida, Jacksonville Dave Saperstein, M.D., Director, Center for Complex Neurology, EDS & POTS Aziz Shaibani, M.D., FACP, FAAN, Clinical Professor of Medicine, Baylor College of Medicine, and Director, Nerve and Muscle Center of Texas Gil Wolfe, M.D., Irvin & Rosemary Smith Professor & Chairman, Dept. of Neurology, University at Buffalo/SUNY Publishing Facilitators Marianne Reed, Digital Publishing Services, University of Kansas Libraries Eric Bader, Digital Publishing Services, University of Kansas Libraries Cover Image: Top: “Yo Soy-ee Blaxican”, Vincent Valdez. Bottom: “Ah Yes, That Notorious Place Everyone Speaks Of”, Vincent Valdez. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial 1 No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) 1 CONTENTS WHAT’S ON YOUR MIND? Letter from the Founding Facilitator 1 Richard J. Barohn, MD DTC Advertising on TV Illustrates the Corruption and Inequity of the US Medical Care System 3 Joshua Freeman, MD Remembering Dr. Patricia Bath for Women’s History Month: Ophthalmologist, inventor, and humanitarian with many firsts 5 Richard J. Barohn, MD The Last Ride 7 Raghav Govindarajan, MD Some Notes on the Subject of Shame and Recovery 9 Walter F. Ricci, MD Shame and State of the Self and Its Implications for Technique 10 Walter F. Ricci, MD On the 25th Anniversary of the Kansas City Psychoanalytic Institute 17 Walter F. Ricci, MD NEW STUFF Efficacy of Botulinum Toxin for Treating Cramps in Peripheral Neuropathy 19 Tejas R. Mehta, MBBS; Richard Sommers; Raghav Govindarajan, MD Amyotrophic Lateral Sclerosis and Multiple Sclerosis: More Evidence Suggesting a Link 23 Kristyn Pocock, MD; Idil Baysal, BA MSN RN; James Scanlan, PhD; Michael Elliott, MD; Angeli Mayadev, MD Duration and Temporal Dispersion Measurements in CIDP Subjects from the Polyneuropathy and Treatment with Hizentra (PATH) Study 27 D. Menon, MD; J. Vijayan, MD; John-Philip Lawo, PhD; Orell Mielke, MD; M. Ngo, RT; J. Dela Cruz; V. Bril, MD, FCRP Rapid Rate Intravenous Immunoglobulin Administration: Safety Outcomes in 11,334 Infusions 35 Nazia Rashid, PharmD, MS; Michael Rigas, PharmD; Fawad Piracha, PharmD; Syeda L. Alqadri, MD This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) 2 CLINIC STUFF Long Standing DADS Variant of CIDP Preceding AL Amyloidosis: A sentinel event or serendipitous association? 41 Deepak Menon, MD; Sara Alnajjar, MD; Vera Bril, MD, FRCP(C) Significance of Transaminitis in Guillian Barre Syndrome 46 Sachin M. Bhagavan, MD; Swathi Beladakere Ramaswamy, MD; Manjamalai Sivaraman, MD; Raghav Govindarajan, MD Myasthenia Gravis and Pericarditis in a Patient with Thymoma 48 Ryan W. Fogg, BS; Lillian C. Flashner, BS; William J. Marte, MD; Rabia B. Choudry, MD; Anishee S. Undavia, MD; Aparna M. Prabhu, MD GNE Myopathy with Thrombocytopenia: A case report and review of the literature 52 Joshua Rim, MD; Yuebing Li, MD, PhD MuSK+ Myasthenia Gravis Presenting with Severe Sleep Apnea, Respiratory Dysfunction and Response to Rituximab 55 Monica Alcantara, MD; Clodagh Ryan, MD; Nathan Stall, MD; Robert Jackson; Neha Patel, MD; Hans Katzberg, MD PROPOSED STUFF Comparative Effectiveness of Intravenous Immunoglobulin (IVIg) and Subcutaneous 60 Immunoglobulin (SCIg) versus Historical Controls in Management of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Mamatha Pasnoor, MD; Mazen M. Dimachkie, MD; Byron Gajewski, PhD; Lemuel Russell Waitman, PhD; Andrew Heim, BSc; Kim Kimminau, PhD; Richard J. Barohn, MD; Greater Plains Collaborative PCORnet Phase II Study of Arimoclomol in IBM FDA-OOPD (Orphan Products Division) R01 104 Mazen Dimachkie, MD; Michael Hanna, MD; Pedro Machado, MD; Laura Herbelin, BS; Mamatha Pasnoor, MD; Omar Jawdat, MD; April McVey, MD; Jeffrey Statland, MD; Melanie Glenn, MD; Linda Greensmith, PhD; Bill Martens, PhD; Rabi Tawil, MD; Michael McDermott, PhD; Richard J. Barohn, MD ART AND OTHER STUFF MRI of a Poet’s Brain 143 Vernon Rowe, MD Remembrance 144 Elizabeth Snow Rowe, PhD, MBA 27 Crossroads 145 Walter Anderson This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) 3 What’s On Your Mind? Letter from the Founding Facilitator (GBS). The neurology group in Philadelphia led by Dr. Richard J. Barohn, MD Prabhu has an interesting case first authored by student Ryan Fogg of a myasthenia gravis (MG) patient with a Welcome to Vol 2 / Issue 3 of the RRNMF thymoma and the complication of pericarditis. Drs Rim Neuromuscular Journal. This issue once again contains a and Li from the Cleveland Clinic describe the association of plethora of new neuromuscular information. In addition, we GNE myopathy and thrombocytopenia, which interestingly once again are publishing some wonderful pieces from the has previously been reported, and they review the literature. arts and sciences that are not neuromuscular at all, but very Dr. Alcantara and her team in Toronto, led by Dr. Hans much worth reading. The first section begins with “What’s Katzberg, describe a complicated case presenting with on Your Mind?,” and I have asked Dr. Joshua Freeman dyspnea and sleep apnea who was ultimately diagnosed to again allow us to publish one of his insightful articles with MG and MuSK antibodies and who responded to he posts on his blog sites (he has two of them) about the Rituximab. dangers surrounding medically related direct-to-consumer In the Proposed Stuff category, we are publishing two advertising on TV. I have an article I first wrote for one of grants: one that was not funded and one that was funded. my Executive Vice Chancellor messages at the University The Kansas/Missouri group is publishing an unsuccessful of Missouri in honor of Black History Month; I highlighted PCORI grant we submitted several years ago. This was a the amazing career of Dr. Patricia Bath, a pioneer in proposal to do a comparative effectiveness study in CIDP of Ophthalmology. Dr. Raghav Govindarajan has another intravenous immunoglobulin (IVIg) versus subcutaneous great article about a journey he and a patient took together immunoglobulin (SCIg). We are attaching the critiques through their physician-patient relationship he titled “The from the reviewers, the ultimate (and painful) peer review. Last Ride”. In an attempt to expose my neuromuscular The purpose of publishing unfunded grant attempts and colleagues to some old-fashioned psychoanalytic thinking, critiques is several-fold. If others are considering studying I have asked my good friend and psychoanalyst Walter Ricci this clinical question, they do not have to start from ground MD to allow us to publish two of his short pieces on the role zero and can see where others have tread and failed. If of “shame” in our lives. This year is also the 25th anniversary that happens, hopefully another group will take what we of the Kansas City Psychoanalytic Institute, which Dr. Ricci proposed and the critiques and come up with a better and founded with several colleagues. We are publishing a short findable approach. Another is of course that a great deal piece Dr. Ricci wrote for that organization’s newsletter. Yes, of time, effort, and teamwork goes into preparing these my neuromuscular friends, despite rumors
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