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WO 2013/079708 Al 6 June 2013 (06.06.2013) P O P C T (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2013/079708 Al 6 June 2013 (06.06.2013) P O P C T (51) International Patent Classification: Limited, Jealott's Hill International Research Centre, A01N 43/14 (2006.01) C07D 215/227 (2006.01) Bracknell Berkshire RG42 6EY (GB). C07D 309/06 (2006.01) C07C 49/747 (2006.01) (74) Agents: SYNGENTA LIMITED et al; Intellectual Prop (21) International Application Number: erty Department, Syngenta Limited, P.O. Box 3538, PCT/EP20 12/074 172 Jealott's Hill International Research Centre, Bracknell Berkshire RG42 6YA (GB). (22) International Filing Date: 30 November 2012 (30.1 1.2012) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (25) Filing Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 3448/DEL/201 1 30 November 201 1 (30. 11.201 1) IN KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (71) Applicants (for all designated States except US): SYN- ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, GENTA LIMITED [GB/GB]; European Regional Centre, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, Priestley Road, Surrey Research Park, Guildford Surrey RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, GU2 7YH (GB). SYNGENTA PARTICIPATIONS AG TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, [CH/CH]; Schwarzaldallee 215, CH-4058 Basel (CH). ZM, ZW. (72) Inventors; and (84) Designated States (unless otherwise indicated, for every (71) Applicants (for US only): AVERY, Alaric James kind of regional protection available): ARIPO (BW, GH, [GB/GB]; Syngenta Limited, lealott's Hill, International GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, Research Centre, Bracknell Berkshire RG42 6EY (GB). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, PHADTE, Mangala Mahadev [IN/IN]; Syngenta Bios TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, ciences Pvt.Limited, Santa Monica Works, Corlim, Ilhas, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, FT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Goa 403 110 (IN). SCUTT, James Nicholas [GB/GB]; Syngenta Limited, Jealott's Hill, International Research TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Centre, Bracknell Berkshire RG42 6EY (GB). TAYLOR, John Benjamin [GB/GB]; Syngenta Limited, Jealott's Hill Published: International Research Centre, Bracknell Berkshire RG42 — with international search report (Art. 21(3)) 6EY (GB). VINER, Russell Colin [GB/GB]; Jealott's Hill International Research Centre, Bracknell Berkshire RG42 — before the expiration of the time limit for amending the 6EY (GB). WAILES, Jeffrey Steven [GB/GB]; Syngenta claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: 2-(SUBSTITUTED-PHENYL)-CYCLOPENTANE-l,3-DIONE COMPOUNDS, AND DERIVATIVES THEREOF o00 (I) © (57) Abstract: The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R 1 is methyl or chlor o ine; R2 is hydrogen, methyl, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, fluorine, chlorine, bromine, methoxy, ethoxy or fluorometh- oxy; and G, R3, R4, R5 and R6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of con - o trolling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof. 2-(Substituted-phenyl)-cyclopentane-1,3-dione compounds, and derivatives thereof The present invention relates to novel, herbicidally active cyclopentanedione compounds, specifically 2-(substituted-phenyl)-cyclopentane-1 ,3-dione compounds, and derivatives thereof (e.g. enol ketone tautomer and/or fused and/or spirocyclic bicyclic derivatives thereof), to processes for their preparation, to herbicidal compositions comprising those compounds, and to their use in controlling weeds such as grassy monocotyledonous weeds, especially in crops of useful plants, or in inhibiting undesired plant growth. Cyclopentanedione compounds substituted by substituted-phenyl and having herbicidal activity are described, for example, in WO 2010/000773 A 1, WO 2010/069834 A 1, WO 2010/089210 A 1, WO 201 0/1 02848 A 1 and WO 201 1/007146 A 1 (all Syngenta Limited et al.). For example, WO 2010/000773 A 1 (Syngenta Limited) discloses 5-(heterocyclylalkyl)-3- hydroxy-2-phenylcyclopent-2-enone compounds and certain derivatives thereof as herbicides. Also, for example, WO 2010/069834 A 1 (Syngenta Limited) discloses cyclopentane-1 ,3-diones having both heteroarylmethyl- and 2-(substituted-phenyl)- substituents on the cyclopentane ring, and derivatives thereof containing latentiating groups; these compounds are disclosed as having herbicidal properties. Fused bicyclic and oxygen-bridged cyclopentanedione derivatives, specifically 10-oxatricyclo-[5.2.1 .02,6]decane-3,5-diones and derivatives, which are substituted by substituted-phenyl and which have herbicidal activity, are disclosed in WO 2009/019005 A2 (Syngenta Limited). Phenyl-substituted bicyclooctane-1 ,3-dione derivatives, and their use as pesticides and/or herbicides, are disclosed in WO 2010/040460 A2 (Bayer Cropscience AG). Cyclopentane-1 ,3-dione compounds and derivatives (e.g. fused and/or spirocyclic bicyclic derivatives) thereof, which are substituted at the 2-position of the cyclopentane-1 ,3-dione by a phenyl which itself is substituted at the 4-position by (specifically) either prop-1-ynyl or chloroethynyl, and derivatives of the enol ketone tautomer of such cyclopentanediones, which have herbicidal activity and/or plant-growth-inhibiting properties, especially in the control of grassy monocotyledonous weeds and/or when used post-emergence, have now been found, which are encompassed by the present invention. The specific Compounds A-1 to A-29 disclosed hereinafter, which are encompassed by the present invention, appear to have one or more of the following desirable properties as follows: (a) Compounds A-2 to A-12, A-14, A-1 5, A-17 to A-21 , and A-23 to A-29, and to a slightly lesser extent Compounds A-1 , A-13, A-16, and A-22, have potent post-emergence herbicidal activity in the control of a number of grassy monocotyledonous weeds such as Lolium, Alopecurus, Echinochloa and/or Avena, and often also Setaria (see e.g. Biological Examples 1, 2 , 3 and 4 hereinafter). (b) Many or most of Compounds A-2 to A-1 5 and A-17 to A-29 are selective grassy-weed- herbicides (graminicides), when used post-emergence on wheat and/or barley, and when safened on the wheat and/or barley appropriately by the safener cloquintocet-mexyl. (c) Compounds A-6, A-8, A-14, A-20, A-23 and A-26 appear to have quite a low half-life within soil, i.e. quite a low soil persistence (see Biological Example 5 hereinafter), which may lead to certain environmental and/or regulatory advantages such as: the compound not persisting for too long in the environment after spraying on a field, and/or possibly a reduced potential to leach into and/or to negatively affect groundwater. Therefore, in a first aspect of the present invention, there is provided a compound of formula (I): X is methyl or chlorine; R is methyl or chlorine; R2 is hydrogen, methyl, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, fluorine, chlorine, bromine, methoxy, ethoxy orfluoromethoxy; 3 4 5 R , R and R , independently of each other, are hydrogen, -C5alkyl (e.g. CrC 4alkyl, e.g. CrC 2alkyl), C2-C4 alkenyl (e.g. C 2-C3alkenyl-CH 2-, e.g. ethenyl-CH 2-), C2-C4alkynyl (e.g. C2-C3alkynyl-CH 2-, e.g. ethynyl-CH 2-), Ci-C 2fluoroalkyl or Ci-C 3alkoxyCi-C 3alkyl; and 6 R is: hydrogen; -C5alkyl (in particular CrC 4alkyl, e.g. CrC 2alkyl); C2-C4 alkenyl (in particular C2-C3alkenyl-CH 2-, e.g. ethenyl-CH 2-); C2-C4alkynyl (preferably C2-C3alkynyl-CH 2-, 6 ≡ more preferably ethynyl-CH 2-); R -C C-CH 2-; Ci-C 2fluoroalkyl; Ci-C 3alkoxyCi-C 3alkyl; Ci-C 3alkylthioC C3alkyl; Ci-C 3alkylsulfinylC C3alkyl; Ci-C 3alkylsulfonylC C3alkyl; C3- C4cycloalkyl (in particular cyclopropyl); or an unsubstituted 4 , 5 or 6 (in particular 4 or 5) membered monocyclic heterocyclyl having one ring heteroatom independently selected from oxygen, sulfur and nitrogen, and attached at a ring carbon atom within the heterocyclyl (preferably tetrahydrofuranyl such as tetrahydrofuran-3-yl, or tetrahydropyranyl such as tetrahydropyran-4-yl); 6 7 7 or R is Q-(CH2)m-CH(R )-, wherein m is 0 or 1 (preferably m is 0), and either R is hydrogen or R7 and R5 together are a bond, and Q is an optionally substituted heterocyclyl as defined below; or R6 is Het-CH(R8)-, wherein either R8 is hydrogen or R8 and R5 together are a bond, and Het is an optionally substituted heteroaryl as defined below; 6 or R is C3-C6cycloalkylCrC 2alkyl- (in particular C3-C6cycloalkylmethyl-); or is C4-C6cycloalkylCrC 2alkyl- (in particular C4-C6cycloalkylmethyl-) substituted, at a cycloalkyl ring-carbon atom which is not the ring-carbon atom attached to the -Ci-C 2alkyl- moiety and which is not bonded
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