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WO 2016/074683 Al 19 May 2016 (19.05.2016) W P O P C T

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WO 2016/074683 Al 19 May 2016 (19.05.2016) W P O P C T (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/074683 Al 19 May 2016 (19.05.2016) W P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12N 15/10 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/DK20 15/050343 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 11 November 2015 ( 11. 1 1.2015) KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (25) Filing Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (26) Publication Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: PA 2014 00655 11 November 2014 ( 11. 1 1.2014) DK (84) Designated States (unless otherwise indicated, for every 62/077,933 11 November 2014 ( 11. 11.2014) US kind of regional protection available): ARIPO (BW, GH, 62/202,3 18 7 August 2015 (07.08.2015) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: LUNDORF PEDERSEN MATERIALS APS TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, [DK/DK]; Nordvej 16 B, Himmelev, DK-4000 Roskilde DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (DK). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors; and GW, KM, ML, MR, NE, SN, TD, TG). (71) Applicants : LUNDORF, Mikkel Dybro [DK/DK]; Nordvej 16 B, DK-4000 Roskilde (DK). PEDERSEN, Declarations under Rule 4.17 : Henrik [DK/DK]; Skovalleen 36, DK-2880 Bagsvsrd — as to the identity of the inventor (Rule 4.1 7(Ϊ)) (DK). — of inventorship (Rule 4.17(iv)) (72) Inventor: DEHLI, Tore; Taksvsnget 12, DK-5270 Odense N (DK). Published: (74) Agents: KLINGE, Ulla et al; Inspicos P/S, Kogle Alle 2, — with international search report (Art. 21(3)) DK-2970 H0rsholm (DK). o (54) Title: METHOD FOR IDENTIFICATION OF MOLECULES WITH DESIRED CHARACTERISTICS (57) Abstract: A method for identifying molecules with desired characteristics such as high affinity for a surface or material is de- scribed. A particularly useful method covered by the present invention allows identification of molecules which bind a material with high affinity in the presence of fluid or soluble polymers, such that said molecules can be used to produce a composite in which they efficiently anchor a material in a matrix comprising solid forms of a polymer. Compositions/kits useful for identification of mo - lecules with desired characteristics are also described. TITLE: Method for identification of molecules with desired characteristics FIELD OF THE INVENTION The present invention relates to methods for identifying one or more molecules with desired characteristics such as a desired affinity for a surface or a material or such as affinity for a specific site on a surface or material. Furthermore, the present invention relates to kits/compositions useful for identifying molecules with desired characteristics. In addition, the present invention relates to the use of said identified molecules to modulate a material or surface, such as to modulate one or more characteristics of a material or surface. For example, said identified molecules of the present invention may be used to interact with, stabilize, coat, bind to, purify, enhance a characteristic of, protect, enable the production of, assemble, improve the production of, or improve the processing of, a surface or material. BACKGROUND OF THE INVENTION There is great interest in the development of surfaces or materials with new or improved characteristics. Said characteristics may be controlled at the nanoscale or molecular level. Many materials are composites (composed of components - typically a matrix, such as a polymer, and a filler/additive, such as carbon nanotubes or graphene) and it is critical to control the interaction of the components at the molecular level. For example, fullerenes such as carbon nanotubes and graphene may be added as fillers to improve characteristics such as Young's modulus and/or tensile strength of materials comprising a polymer (e.g. plastic) matrix. Often, a characteristic of a filler is not efficiently transferred to (or manifest in) the resulting composite material unless the interaction of matrix and filler is efficient at the molecular level. To control, e.g. optimize, said interaction it is necessary to identify molecules with desired characteristics such as a high binding affinity to a filler and/or high binding affinity to a polymer. Thus, methods for systematically and efficiently identifying molecules with desired characteristics are needed. The present invention provides such methods. SUMMARY OF THE INVENTION It has been found by the present inventors that molecules with desired characteristics, such as a high affinity to an inorganic material in a polymer composite, can be identified by methods which include conditions which mimic conditions in said composite. So, in a first aspect the present invention relates to a method for identification of molecules with desired characteristics, comprising the steps of: A . Providing a library of molecules of the general composition M(n)-L(k)-T(s) : where n = 0 to 1E+9, k = 0 to 1E+9, and s = 0 to 1E+9, such that n+k+s is at least 1, and where M is a library molecule, T is a tag that may be used to identify the library molecule M to which it is attached, and L is a linker that connects M and T; B. Providing a medium; C. Providing a surface or material; D . Combining said library, medium, surface and/or material; E . Optionally performing one or more manipulations of said library, medium, surface and/or material; F. Partitioning or isolating a fraction of said library; G . Optionally amplifying or copying the whole or a part of one or more molecules; H . Optionally identifying one or more characteristics of one or more library molecules; wherein steps A, B, C, D, E, F, G, and H are performed simultaneously or sequentially in any possible order; and wherein steps A, B, C, D, E, F, G, and H are performed one or more times. In a second aspect the present invention relates to a kit for use in the method according to the invention comprising fullerenes, such as carbon nanotubes and/or graphene, and a molecule library. In a third aspect the present invention relates to a use of molecules identified by the method according to the invention to modulate a material or surface. Definitions Analog The term, "analog" as used herein, shall be defined as an entity which shares one or more characteristics with another entity. For example, a nucleotide analog is an entity which can hybridize to another nucleotide. As another example, an oligomer may be an analog of a polymer analog, e.g. tri-ethylene is an analog of polyethylene. Detergent The term, "detergent" as used herein, refers to a surfactant or a mixture of surfactants. Display oligo The term, "display oligo" as used herein, refers to an entity, which comprises a linker and an oligomer, such as an oligonucleotide. Electrical resistivity The term, "electrical resistivity" as used herein, refers to resistivity, specific electrical resistance, or volume resistivity and is a measure of how strongly a material opposes the flow of electric current. A low resistivity indicates a material that readily allows the movement of electric charge. The SI unit of electrical resistivity is the ohm metre [Ωm]. Elution The term, "elution" as used herein, refers to the process whereby molecules are partitioned from a material or surface, for example when a fraction of a molecule library bound to a surface is removed from said surface. Fluid The term, "fluid" as used herein, refers to a substance that continually deforms (flows) under an applied shear stress. All gases are fluids, but not all liquids are fluids. Hydrogen bond acceptor (HBA) The term, "hydrogen bond acceptor" as used herein, refers to chemical moiety which can bind to hydrogen, such as fluorine, nitrogen, oxygen, sulfur. Hydrogen bond donor (HBD) The term, "hydrogen bond donor" as used herein, refers to chemical moiety which can donate a hydrogen atom such as hydrogens bonded to fluorine, oxygen, or nitrogen. Inorganic Inorganic structural entities or materials shall mean any material or entity except those comprising carbon and at least one other element. Inorganic SEs thus include carbon nanotubes (CNTs), graphene sheets (GSs), other fullerenes, and carbon fibres (CFs). Library The term, "library" is used herein interchangeably with "molecule library" or "library of molecules" meaning a collection or plurality of molecules. Ligand The term "ligand" as used herein shall mean an entity capable of binding covalently or non-covalently to a material, where said entity is a molecule composed of atoms, which binds said material, or which connects at least two atoms that said material. Linker The term "linker" as used herein describes an entity which links one or molecules or molecule fragments to one or more tags. Material The term, "material" as used herein, describes anything made of matter.
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