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Amended Safety Assessment of Achillea Millefolium-Derived Ingredients As Used in Cosmetics

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Amended Safety Assessment of Achillea Millefolium-Derived Ingredients As Used in Cosmetics Amended Safety Assessment of Achillea Millefolium-Derived Ingredients as Used in Cosmetics Status: Tentative Amended Report for Public Review Release Date: June 21, 2013 Panel Meeting Date: September 9-10, 2013 All interested persons are provided 60 days from the above date to comment on this Tentative Safety Assessment and to identify additional published data that should be included or provide unpublished data which can be made public and included. Information may be submitted without identifying the source or the trade name of the cosmetic product containing the ingredient. All unpublished data submitted to CIR will be discussed in open meetings, will be available at the CIR office for review by any interested party and may be cited in a peer-reviewed scientific journal. Please submit data, comments, or requests to the CIR Director, Dr. F. Alan Andersen. The 2013 Cosmetic Ingredient Review Expert Panel members are: Chairman, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; Ronald A Hill, Ph.D. James G. Marks, Jr., M.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Director is F. Alan Andersen, Ph.D. This report was prepared by Lillian C. Becker, Scientific Analyst/Writer. © Cosmetic Ingredient Review 1101 17th Street, NW, Suite 412 Washington, DC 20036-4702 ph 202.331.0651 fax 202.331.0088 cirinfo@cir-safety.org i TABLE OF CONTENTS TABLE OF CONTENTS............................................................................................................................................................. ii ABSTRACT ................................................................................................................................................................................ 3 INTRODUCTION ....................................................................................................................................................................... 3 Original Safety Assessment ..................................................................................................................................................... 3 CHEMISTRY .............................................................................................................................................................................. 3 Definition ................................................................................................................................................................................ 3 Physical and Chemical Properties ........................................................................................................................................... 3 Constituents......................................................................................................................................................................... 4 Method of Manufacture ........................................................................................................................................................... 4 Impurities ................................................................................................................................................................................ 4 USE .............................................................................................................................................................................................. 4 TOXICOKINETICS .................................................................................................................................................................... 4 Absorption, Distribution, Metabolism, and Excretion ............................................................................................................. 4 Cytotoxicity ............................................................................................................................................................................. 5 TOXICOLOGICAL STUDIES ................................................................................................................................................... 5 Acute Toxicity ......................................................................................................................................................................... 5 Oral – Non-Human.............................................................................................................................................................. 5 Intraperitoneal ..................................................................................................................................................................... 5 Repeated Dose Toxicity .......................................................................................................................................................... 5 Oral – Non-Human.............................................................................................................................................................. 5 REPRODUCTIVE AND DEVELOPMENTAL TOXICITY ...................................................................................................... 5 GENOTOXICITY ....................................................................................................................................................................... 6 In Vitro .................................................................................................................................................................................... 6 IRRITATION AND SENSITIZATION ...................................................................................................................................... 6 Irritation ................................................................................................................................................................................... 6 Dermal – Non-Human ......................................................................................................................................................... 6 Ocular .................................................................................................................................................................................. 6 Sensitization ............................................................................................................................................................................ 6 Dermal – Non-Human ......................................................................................................................................................... 6 Dermal – Human ................................................................................................................................................................. 6 CLINICAL USE .......................................................................................................................................................................... 7 Case Studies ............................................................................................................................................................................ 7 SUMMARY ................................................................................................................................................................................. 7 DISCUSSION .............................................................................................................................................................................. 7 CONCLUSION............................................................................................................................................................................ 8 TABLES AND FIGURES ........................................................................................................................................................... 8 REFERENCES .......................................................................................................................................................................... 14 ii ABSTRACT Cosmetic ingredients derived from Achillea millefolium function in cosmetics as skin-conditioning agents – miscellaneous, skin-conditioning agents – humectants; and fragrance ingredients. The Panel reviewed relevant animal and human data to determine their safety in cosmetics. Because more than one botanical ingredient may be used in a formulation, caution was urged to avoid reaching levels of concern from an accumulation of toxicological and allergenic constituent chemicals and impurities such as pesticides. The CIR Expert Panel concluded that achillea millefolium extract, achillea millefolium flower extract, and achillea millefolium flower/leaf/stem extract are safe in the present practices of use and concentration in cosmetics. INTRODUCTION This is a tentative amended safety assessment of Achillea millefolium (yarrow)-derived ingredients. These ingredients function in cosmetics as skin-conditioning agents – miscellaneous, skin-conditioning agents – humectants; and fragrance ingredients. The three ingredients in this safety assessment are: • achillea millefolium extract, • achillea millefolium flower/leaf/stem extract, and • achillea millefolium flower extract. In 2001, the Cosmetic Ingredient Review (CIR) published a safety assessment of achillea millefolium extract as used in cosmetics.1 The CIR Expert Panel concluded that there were insufficient data to determine the
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