JAMA Network | JAMA | Association of Seafood Consumption, Brain Mercury Level, and APOE Ε4 Status with Brain Neuropathology in Older Adults

JAMA Network | JAMA | Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults

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Original Investigation | February 2, 2016 Association of Seafood Consumption, Brain Some tools below are only available to our Mercury Level, and APOE ε4 Status With Brain subscribers or users with an online account.

Neuropathology in Older Adults Print PDF Martha Clare Morris, ScD1; John Brockman, PhD2; Julie A. Schneider, MD, MS3,4,5; Yamin Wang, PhD1; David Email Get Citation A. Bennett, MD3,4; Christy C. Tangney, PhD6; Ondine van de Rest, PhD7

[+] Author Affiliations Get Permissions Get Alerts Submit a Letter Supplemental Content JAMA. 2016;315(5):. doi:10.1001/jama.2015.19451. Text Size: A A A

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Objective To determine whether seafood consumption is correlated with increased brain mercury levels Create a free personal account and also whether seafood consumption or brain mercury levels are correlated with brain neuropathologies.

Design, Setting, and Participants Cross-sectional analyses of deceased participants in the Purchase Options Memory and Aging Project clinical neuropathological cohort study, 2004-2013. Participants resided in • Buy this article Chicago retirement communities and subsidized housing. The study included 286 autopsied brains of 554 • Subscribe to the journal deceased participants (51.6%). The mean (SD) age at death was 89.9 (6.1) years, 67% (193) were women, and the mean (SD) educational attainment was 14.6 (2.7) years. Related Content Exposures Seafood intake was first measured by a food frequency questionnaire at a mean of 4.5 years Customize your page view by dragging & before death. repositioning the boxes below.

Main Outcomes and Measures Dementia-related pathologies assessed were Alzheimer disease, See Also... Lewy bodies, and the number of macroinfarcts and microinfarcts. Dietary consumption of seafood and n-3 fatty acids was annually assessed by a food frequency questionnaire in the years before death. Tissue Editorial concentrations of mercury and selenium were measured using instrumental neutron activation analyses. Fish Consumption, Brain Mercury, and Neuropathology in Patients With Alzheimer Results Among the 286 autopsied brains of 544 participants, brain mercury levels were positively Disease and Dementia

http://jama.jamanetwork.com/article.aspx?articleid=2484683[2016/02/23 22:14:14] JAMA Network | JAMA | Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults

correlated with the number of seafood meals consumed per week (ρ = 0.16; P = .02). In models adjusted JAMA. 2016;315(5):465-466. for age, sex, education, and total energy intake, seafood consumption (≥ 1 meal[s]/week) was significantly doi:10.1001/jama.2016.0005. correlated with less Alzheimer disease pathology including lower density of neuritic plaques (β = −0.69 score units [95% CI, −1.34 to −0.04]), less severe and widespread neurofibrillary tangles (β = −0.77 score units [95% CI, −1.52 to −0.02]), and lower neuropathologically defined Alzheimer disease (β = −0.53 score Related Multimedia units [95% CI, −0.96 to −0.10]) but only among apolipoprotein E (APOE ε4) carriers. Higher intake levels of α-linolenic acid (18:3 n-3) were correlated with lower odds of cerebral macroinfarctions (odds ratio for Author Video Interviews tertiles 3 vs 1, 0.51 [95% CI, 0.27 to 0.94]). Fish oil supplementation had no statistically significant Seafood Consumption, Mercury, and Brain correlation with any neuropathologic marker. Higher brain concentrations of mercury were not Neuropathology in Older Adults (4:59) significantly correlated with increased levels of brain neuropathology. JAMA Report Video Conclusions and Relevance In cross-sectional analyses, moderate seafood consumption was Seafood Consumption, Mercury, and Brain correlated with lesser Alzheimer disease neuropathology. Although seafood consumption was also Neuropathology in Older Adults (2:09) correlated with higher brain levels of mercury, these levels were not correlated with brain neuropathology. Author Interview Seafood Consumption, Mercury, and Brain Neuropathology in Older Adults (04:28) Purchase Options Sign in

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