DNA Methylation Variations in Familial Female and Male Breast Cancer
ONCOLOGY LETTERS 21: 468, 2021 DNA methylation variations in familial female and male breast cancer EDOARDO ABENI1, ILARIA GROSSI1, ELEONORA MARCHINA1, ARIANNA CONIGLIO2, PAOLO INCARDONA3, PIETRO CAVALLI4,5, FAUSTO ZORZI6, PIER LUIGI CHIODERA7, CARLO TERENZIO PATIES8, MARIALUISA CROSATTI9, GIUSEPPINA DE PETRO1 and ALESSANDRO SALVI1 1Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia; 2Department of Clinical and Experimental Sciences, Surgical Clinic, University of Brescia; 3Anatomic Pathology, Spedali Civili Brescia, I‑25123 Brescia; 4Breast Unit, ASST‑Bergamo Est, I‑24068 Bergamo; 5ASST of Cremona, Hospital of Cremona, I‑26100 Cremona; 6Department of Pathology, Fondazione Poliambulanza, I‑25124 Brescia; 7Pathology Unit, Istituto Clinico Sant'Anna, I‑25127 Brescia; 8Department of Oncology and Hematology, Pathology Unit, ‘Guglielmo da Saliceto’ Hospital, I‑29121 Piacenza, Italy; 9Department of Respiratory Sciences, University of Leicester, LE1 7RH Leicester, UK Received July 24, 2020; Accepted February 16, 2021 DOI: 10.3892/ol.2021.12729 Abstract. In total, ~25% of familial breast cancer (BC) is several cancer‑associated pathways were among the most attributed to germline mutations of the BRCA1 and BRCA2 enriched KEGG pathways of differentially methylated genes genes, while the rest of the cases are included in the BRCAX when the BRCA2 group was compared with the BRCAX group. BC is also known to affect men, with a worldwide or BRCA1+BRCAX groups. The comparison between the incidence of 1%. Epigenetic alterations, including DNA meth‑ BRCA1 and BRCA2+BRCAX groups comprised the molecular ylation, have been rarely studied in male breast cancer (MBC) function term ‘cytoskeletal protein binding’. Finally, the func‑ on a genome‑wide level.
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