Supplementary file 1: Search strategy
Search strategy for MEDLINE
1. depressive disorder"[MeSH Terms]
2. depressive
3. 1 OR 2
4. disorder
5. depressive disorder
6. depression
7. depression"[MeSH Terms]
8. depressive
9. 4 OR 5 OR 6 OR 7 OR 8
10. mace
11. macce
12. "major adverse cardiac event"
13. "major adverse cardiac events"
14. "Major Adverse Cardiac and Cerebrovascular event"
15. "Major Adverse Cardiac and Cerebrovascular events"
16. “cardiac death”
17. ("myocardial infarction"[MeSH Terms] OR ("myocardial" AND "infarction") OR
"myocardial infarction") 18. revascularization
19. ("stroke"[MeSH Terms] OR "stroke")
20. ("mortality"[Subheading] OR "mortality" OR "mortality"[MeSH Terms])
21. 10 OR 11 OR 12 OR 13 OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20
22. ("serotonin uptake inhibitors" OR "serotonin uptake inhibitors"[MeSH Terms]
23. ("serotonin" AND "uptake" AND "inhibitors")
24. "serotonin uptake inhibitors"
25. "ssri"
26. (Selective AND ("serotonin"[MeSH Terms] OR "serotonin") AND re-uptake AND
("antagonists and inhibitors"[Subheading] OR ("antagonists" AND "inhibitors") OR
"antagonists and inhibitors" OR "inhibitors"))
27. (serotonin-specific AND reuptake AND ("antagonists and inhibitors” OR ("antagonists"
AND "inhibitors"[Subheading]) OR "antagonists and inhibitors" OR "inhibitors"))
28. "citalopram"[MeSH Terms] OR "citalopram"
29. "fluoxetine"[MeSH Terms] OR "fluoxetine"
30. "paroxetine"[MeSH Terms] OR "paroxetine"
31. "sertraline"[MeSH Terms] OR "sertraline"
32. "alaproclate"[Supplementary Concept] OR "alaproclate”
33. "fluvoxamine"[MeSH Terms] OR "fluvoxamine"
34. "etoperidone"[Supplementary Concept] OR "etoperidone" 35. "citalopram"[MeSH Terms] OR "citalopram" OR "escitalopram"
36. "zimeldine"[MeSH Terms] OR "zimeldine" OR "zimelidine"
37. 22 OR 23 OR 24 OR 25 OR 26 OR 27 OR 28 OR 29 OR 30 OR 31 OR 32 OR 33 OR 34
OR 35 OR 36
38. randomized controlled trial[pt]
39. controlled clinical trial[pt]
40. randomized[tiab]
41. placebo[tiab]
42. clinical trials as topic[mesh:noexp]
43. randomly[tiab]
44. trial[ti]
45. (animals[mh] NOT humans [mh])
46. 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44 NOT 45
47 21 AND 37 AND 46
48. "humans"[MeSH Terms]
49. 47 AND 48
50. English[lang]
51. 49 AND 50
Date of Search: 01/31/2017
Results: 234 articles found Search strategy for EMBASE
1. 'depression'/exp
2. depression
3. depressive
4. 1 OR 2 OR 3 OR
5. 'mace'/exp
6. mace
7. mace
8. 'major adverse cardiac event'/exp
9. 'major adverse cardiac event'
10. 'major adverse cardiac events'
11. 'major adverse cardiac and cerebrovascular event'/exp
12. 'major adverse cardiac and cerebrovascular event'
13. 'major adverse cardiac and cerebrovascular events'
14. 'cardiac death'/exp
15. OR 'cardiac death'
16. 'mortality'/exp
17. mortality
18. 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11 OR 12 OR 13 OR 14 OR 15 OR 16 OR 17 OR 19. 'ssri'/exp
20. ssri
21. selective
22. 'serotonin'/exp OR serotonin
23. 're uptake'
24. 'inhibitors'/exp OR inhibitors
25. 'serotonin specific'
26. reuptake
27. 'inhibitors'/exp OR inhibitors
28. 'citalopram'/exp
29. citalopram
30. 'fluoxetine'/exp
31. fluoxetine
32. 'paroxetine'/exp
33. paroxetine
34. 'sertraline'/exp
35. sertraline
36. 'alaproclate'/exp
37. alaproclate 38. 'fluvoxamine'/exp
39. fluvoxamine
40. 'etoperidone'/exp
41. etoperidone
42. 'escitalopram'/exp
43. escitalopram
44. 'zimelidine'/exp
45. zimelidine
46. 19 OR 20 OR 21 AND 22 AND 23 AND 24 OR 25 AND 26 AND 27 OR 28 OR 29 OR 30
OR 31 OR 32 OR 33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43
OR 44 OR 45
47 'crossover procedure':de
48. 'double-blind procedure':de
49. 'randomized controlled trial':de
50. 'single-blind procedure':de
51. random*:de,ab,ti
52. factorial*:de,ab,ti
53. crossover*:de,ab,ti
54. (cross NEXT/1 over*): de,ab,ti
55. placebo*:de,ab,ti 56. (doubl* NEAR/1 blind*):de,ab,ti
57. (singl* NEAR/1 blind*):de,ab,ti
58. assign*:de,ab,ti
59. allocat*:de,ab,ti
60. volunteer*:de,ab,ti)
61. [english]/lim
62. 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55 OR 56 OR 57 OR 58 OR 59
OR 60 OR 61
63. 18 AND 46 AND 62
Date of Search: 01/31/2017
Results: 828 articles found
Search strategy for Cochrane
1. depression
2. depressive
3. 1 OR 2
4. mace
5. mace
6. "major adverse cardiac event"
7. "major adverse cardiac events"
8. "Major Adverse Cardiac and Cerebrovascular event"
9. "Major Adverse Cardiac and Cerebrovascular events"
10. "cardiac death"
11. mortality
12. 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11
13. SSRI
14. Selective serotonin re-uptake inhibitors
15. serotonin-specific reuptake inhibitors
16. Citalopram
17. Fluoxetine
18. Paroxetine 19. Sertraline
20. Alaproclate
21. Fluvoxamine
22. Etoperidone
23. Escitalopram
24. Zimelidine
25. 13 OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22 OR 23 OR 24
26. 3 AND 12 AND 25
Date of Search: 01/31/2017
Results: 8 articles found