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Bull. Org. mond. Sante 1953, 8, 535-589 Bull. World Hlth Org. SELECT BIBLIOGRAPHY ON THE TOXICOLOGY OF PESTICIDES IN MAN AND MAMMALS CHOIX DE RtFERENCES BIBLIOGRAPHIQUES CONCERNANT LES PROPRIETES TOXIQUES DES PESTICIDES * POUR L'HOMME ET LES MAMMIFfERES This bibliography has been prepared from the reference sources available in the Library of the World Health Organization. Medical indexes and abstracting journals, and the bibliographies of many articles and books, were systematically scanned; the final selection and classification were undertaken by Dr. J. M. Barnes. As far as possible the titles of articles are given in the original language; in several cases, however, it has been impossible to verify these and the original title has been replaced by a translation, enclosed in square brackets. Cette bibliographie a et preparee d'apres les differentes sources de documentation accessibles 'a la Bibliotheque de l'Organisation Mondiale de la Sante. Les index bibliographiques medicaux, les p6rio- diques analytiques, ainsi que les bibliographies de nombreux ouvrages et articles, ont ete systematiquement depouilles; le choix definitif et le classement ont et6 effectues par le Dr J. M. Barnes. Dans la mesure du possible, les titres des articles ont ete donnes dans la langue originale; dans quelques cas, cependant, il a ete impos- sible de verifier le titre original, qui a ete remplace par une traduction placee entre crochets. Le terme <(pesticides >> est utilis6 ici pour d6signer les insecticides, les rodenticides, les herbicides, les fongicides et autres produits similaires. 194 - 535- 536 PESTICIDES I. HAZARDS OF USE AND MANUFACTURE I. RISQUES INHERENTS A L'UTILISATION ET A LA FABRICATION A. General A. Ge'ne'ralite'S 1. ABRAMS, H. K. Increased use of agricultural chemicals serious problem for industrial hygienists Industr. Hyg. Newslett. 1950, 10, No. 7, pp. 3-4, 16 2. ABRAMS, H. K. Public health aspects of agricultural chemicals In: American Chemical Society, Division of Agricultural and Food Chemistry, Agricultural control chemicals, Washington, D.C., 1950, pp. 52-55 3. AMERICAN MEDICAL ASSOCIATION, COMMITTEE ON PESTICIDES Health hazards of electric vaporizing devices for insecticides J. Amer. med. Ass. 1952, 149, 367-369 4. AMERICAN MEDICAL ASSOCIATION, COUNCIL ON FOODS AND NUTRITION Health hazards of pesticides J. Amer. med. Ass. 1948,137, 1603 5. ANDREWS, J. M. & SIMMONS, S. W. Developments in the use of the newer organic insecticides of public health importance Amer. J. publ. Hlth, 1948, 38, 613-631 6. ANWIKAR, A. K. The new organic insecticides of public health importance and their use Indian med. J. 1952, 45, 152-156 7. BISHOPP, F. C. Food, health and insecticides Agric. Chemic. 1951, 6, No. 2, pp. 38-40, 97-101 8. BRIESKORN, C. H. Influence of some new pest and weed control agents on our foods Z. Lebensmitt-Untersuch. 1951, 93, 292-298 9. BROWN, A. W. A. Insect control by chemicals, New York, 1951 10. BUSVINE, J. R. The use and abuse of insecticides Practitioner, 1951, 166, 179-188 11. CALIFORNIA STATE DEPARTMENT OF PUBLIC HEALTH Information on two of the newer insecticides Industr. Hyg. Newslett. 1949, 9, No. 2, p. 9 12. CAROZZI, L. Patologia degli agricoltori; le intossicazioni da insetticidi, disinfestanti, erbicidi Folia med. (Napoli), 1950, 33, 97-117 HAZARDS - RISQUES 537 13. CONFERENCE ON THERAPY Household poisonings: II Amer. J. Med. 1950, 8, 372-383 14. CONLEY, B. E. Why the American Medical Association is interested in the pesticide problem Pests, 1949, 17, No. 4, pp. 18-22 15. CONLEY, B. E. & WILSON, J. R. The physician's role in the pesticide problem In: American Chemical Society, Division of Agricultural and Food Chemistry, Agricultural control chemicals, Washington, D.C., 1950, pp. 61-64 16. COON, J. M. Hazards involved in pesticide application Agric. Chemic. 1951, 6, No. 3, pp. 53, 55 17. Danger from the newer insecticides Lancet, 1950, 1, 407-408 18. EICHLER, W. Vergiftungsgefahren mit neuzeitlichen Kontaktinsektiziden Dtsch. GesundhWes. 1949, 4, 1035-1042 19. FAIRHALL, L. T. The newer insecticides Industr. Hyg. Newslett. 1949, 9, No. 7, pp. 8-9, 16 20. FJELDDALEN, J. Are all insecticides poisonous to human beings ? Frukt og Baer, 1951, 4, 13-22 21. FREAR, D. E. H. Chemistry of insecticides, fungicides and pesticides, 2nd ed., New York, 1948 22. GIRARD, P. Les insecticides de synthese au point de vue de 1'hygiene et de la sante publique Rev. Cps Sante milit. 1950, 6, 105-142 23. GREAT BRITAIN, MINISTRY OF AGRICULTURE AND FISHERIES Toxic chemicals in agriculture. Report of the working party, London, 1951 24. HAYES, W. J., JR. Toxicology of insecticides CDC Bull. 1950, 9, 1-3 25. HAYES, W. J., JR. & SIMMONS, W. S. Benefits and hazards of insecticides to public health In: American Chemical Society, Division of Agricultural and Food Chemistry, Agricultural control chemicals, Washington, D.C., 1950, pp. 56-60 26. KAY, K. Health aspects of the new organic insecticides Rep. ent. Soc. Ont. 1950, 1951, 19-26 27. KING, F. C. The dangers of poisonous dusts and sprays Hlth & Soil, 1950, winter, 29-30 28. LEMMON, A. B. Hazards in use of new poisons Citrus Leaves, 1949, 29, No. 7, pp. 6-7, 28 538 PESTICIDES 29. LHOSTE, J. AperVu sur les insecticides organiques de synthese et sur leur emploi a' des fins sani- taires, Paris, Minist&re de la France d'Outre-Mer, 1948 30. Mocsy, J. A kontaktmergek Mag. dllotorv. Lap. 1946, No. 9, pp. 1-8 31. New hazards from agricultural chemicals J. Amer. med. Ass. 1950, 143, 1158-1159 32. New insecticides are dangerous Safety Review, 1949, 6, 10-11 33. Potential hazards of the newer insecticides Amer. J. Med. 1950, 8, 1-3 34. PRINCI, F. Environmental health aspects of certain agricultural pesticides Agric. Chemic. 1951, 6, No. 2, pp. 30-33 35. PRINCI, F. Toxicology and hazard record of the newer pesticides Agric. Chemic. 1952, 7, No. 1, pp. 44, 47, 97, 99, 101 36. RIPPER, W. E. Pest killers must not be man killers World Crops, 1950, 2, 474-477 37. SIMMONS, S. W. Health hazards of economic poisons and related substances Amer. J. trop. Med. 1951, 31, 514-518 38. SKINNER, J. B. Newer occupational diseases New Engl. J. Med. 1950, 243, 482-486 39. SRIVASTAVA, A. S. Hazards of insecticides and solvents to man Indian med. Rec. 1951, 71, 273-276, 313-317, 328-333 40. STARCKE, A. Insects and man Ent. Ber. (Amst.), 1952, 14, 3-6 41. THIEMANN, H. A. New insecticides and rodenticides and their health aspects Amer. Industr. Hyg. Ass. Quart. 1949, 10, 10-15 42. Toxic chemicals in agriculture Brit. med. J. 1951, 1, 628-630 43. Toxic weed-killers and insecticides Brit. med. J. 1951, 1, 639 44. WARD, J. C. Organic pesticides-new health hazards Arch. Induistr. Hyg. 1951, 4, 152-155 45. WEBSTER, R. L. New insecticides: their uses, limitations, and hazard to human health, Olympia, Wash., 1950 (Washington Agricultural Experiment Station, Circular No. 64) HAZARDS - RISQUES 539 46. WELLMAN, R. H. Synthetic chemicals for agriculture Chlem. & Ind. 1948, 62, 914-921; 63, 223-229 47. WILSON, J. R. Are pesticides making your food unsafe ? Hygiea, 1949, 27, 44-45, 66 B. Insecticides: DDT and Related Compounds B. Insecticides: DDT et Composes Voisins 48. ABAD GOMEZ, H. Inocuidad de la adici6n al agua potable de 1 p.p.m. de DDT para la erradicaci6n del 4 Aedes aegypti * Bo1. Ofic. sanit. pan-amer. 1951, 30, 330-337 49. ALESSANDRINI, M. E. Il p-diclorodifeniltricloroetano (DDT) R.C. Ist. sup. Sanita', 1946, 9, 133-148 50. CAMERON, G. R. Risks to man and animals from the use of 2,2-bis(p-chlorphenyl)-1,l,l,-trichlor- ethane (D.D.T.) Brit. med. Bull. 1945, 3, 233-235 51. GORDON, I. Occupational hazard of DDT spraying Brit. J. industr. Med. 1946, 3, 245-249 52. HOLDAWAY, F. G. Uses, dangers and shortcomings of DDT Plantat. Hlth, 1946, 10, No. 1, pp. 20-26 53. KILLIFFER, D. H. Is DDT poisonous ? Sci. Amer. 1946, 174, 5-7 54. LHOSTE, J. Le DDT est-il dangereux ? Nature (Paris), 1947, No. 3144, pp. 301-302 55. MILLER, S. E. DDT in medical practice Curr. med. Dig. 1946, July, 27-33 56. MtUHLENS, K. Ober die Bedeutung der Dichlor-diphenyl-trichlor-methylmethanpraparate als Arthropodengift in der Seuchenbekampfung unter Berijcksichtigung eigener Erfahrungen Dtsch. med. Wschr. 1946, 71, 164-169 57. MULLER, P., DOMENJOZ, R., WIESMANN, R. & BUXTORF, A. Dichlordiphenyltrichloroethan als Insektizid und seine Bedeutung fur die Human- und Veterinarhygiene Ergebn. Hyg. Bakt. 1949, 26, 5-138 540 PESTICIDES 58. Possible hazards from the use of DDT Amer. J. publ. Hlth, 1949, 39, 925-927 59. ROCHTCHIN, I. V. Voprosi gigieni truda v proizvodstve insektitsida DDT Gigiena, 1949, No. 8, pp. 21-26 60. STONE, T. T. & GLADSTONE, L. DDT (dichlorodiphenyltrichloroethane) J. Amer. med. Ass. 1951, 145, 1342 61. VON OETTINGEN, W. F. et al. Appraisal of the toxicity and potential dangers of DDT aerosol No. 304 (US Public Health Service. Project No. T.217, 1945) 62. WEST, T. F. & CAMPBELL, G. A. DDT and newer persistent insecticides, 2nd ed., London, 1950 63. ZEIN-EL-DINE, K. The insecticide DDT J. roy. Egypt. med. Ass. 1946, 29, 38-54 C. Insecticides: Aldrin, Chlordane, Dieldrin, and Toxaphene C. Insecticides: Aldrine, Chlordane, Dieldrine, et Toxaphene 64. PARKER, W. L. & BLACKER, J. H. Toxaphene, a chlorinated hydrocarbon with insecticidal properties, Newark, Del., 1947) (Delaware Agricultural Experiment Station, Bulletin No. 264) D. Insecticides: Gamma-Isomer Benzene Hexachloride and its Isomers D. Insecticides: Hexachlorocyclohexane. Isomere Gamma et Autres Isomires 65. SLADE, R. E. The gamma isomer of hexachlorocyclohexane (Gammexane) Chem. & Ind. 1945, 64, 314-319 E. Insecticides: Organo-Phosphorus Compounds E.
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  • Appendix Common, Trade, and Chemical Names of Pesticides Mentioned in the Present Volume

    Appendix Common, Trade, and Chemical Names of Pesticides Mentioned in the Present Volume

    Appendix Common, trade, and chemical names of pesticides mentioned in the present volume Commonname Tradename Chemical name aldrin Octalene 1,2,3,4,10,1 O-hexachloro-1 ,4,4a,S,8,8a­ hexahydro-1,4-endo-exo-S,8-dimethano­ naphthalene amidithion Thiocron O,O-dimethyl S-(2-methoxyethyl­ carbamoylmethyl) phosphorodithioate azinphos methyl Guthion, Gusathion O,O-dimcthyl S-( 4-oxo-l ,2,3-benzotri­ azin-3-( 4H)-ylmethyl) phosphorodithioate captan Orthocid N -(trichloromethylthio) cyclohex-4-ene- 1,2-dicarboximide carbaryl Sevin 1-naphthyl-mcthylcarbamate carbophenothion Trithion O,O-diethyl S-[(p-chlorophenylthio)­ methyl] phosphorodithioate chlorfenvinphos Birlane (Shell), 2-chloro-1-(2,4-dichlorophenyl) vinyl Sapecron (e/BA) diethyl phosphate chlorphenamidine Galecron N'-( 4-chloro-o-tolyl)-N,N-dimethyl­ formamidine chlorthion Chlorthion O,O-dimethyIO-(3-chloro-4-nitro­ phenyl)-phosphorothioate coumaphos Asuntol, Co-Ral O,O-diethyl O-(3-chloro-4-methyl- 2-oxo-2H-1-benzopyran-7-yl) phosphorothioate DDT Gesarol 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane demeton Systox O,O-diethyl O-(and S)-2-(ethylthio)ethyl phosphorothioates DEF S,S,S-tributyltrithiophosphate demeton methyl Metasystox O,O-dimethyl O-(and S)-2-(ethylthio)­ ethyl phosphorothioates diazinon Diazinon, Basudin O,O-diethyIO-(2-isopropyl-4-methyl- 6-pyrimidyl) phosphorothioate dichlorvos Vapona (Shell), O,O-dimethyl-2,2-dichlorovinyl Nuvan (e/BA) phosphate dicrotophos Bidrin (Shell), O,O-dimethyl O-(2-dimethyl-carbamyl-1- Carbicron (e/BA) methyl) vinyl phosphate dieldrin Octalox
  • Nobel Lecture, December 11, 1948

    Nobel Lecture, December 11, 1948

    P AUL H. MÜLLE R Dichloro-diphenyl-trichloroethane and newer insecticides Nobel Lecture, December 11, 1948 Ladies and Gentlemen. Since Perkin synthesized the first dyestuff in 1856, about 90 years have elapsed. During this period the synthesis of artificial dyestuffs has gone through enormous development. The discovery of fuchsines by Emanuel Verguin in 1859, unlocked the tri- phenylmethane dyestuffs for the dyestuffs chemist. The very important discovery of the diazo compounds by Peter Griess, in 1858, certainly brought about the most significant reaction in the chemistry of dyestuffs, a quite unique impetus to the development of this field of organic chemistry. The most important milestones in this development are: the preparation of Bismarck brown by C. Martius in 1863, of Chrysoidine by O. N. Witt in 1876, and Congo Red, the first dyestuff capable of direct application to cotton, by P. Böttiger in 1884. This large-scale development and the vast mass of experimental material available have called for a variety of attempted explanations. The relation- ships between composition and colour on the one hand, and fastness on the other, were the subjects of several attempts at theoretical explanation. Particularly fruitful in this respect was the theory of O. N. Witt on chro- mophores and auxochromes, and the theory - valid only in special cases - of E. Schirm, J. Prakt. Chem., 144 (1936) 69, concerning the connexion between composition and affinity to cellulose fibre. Thanks to these results the dyestuffs chemist today, after about 90 years of untiring detailed study, is in the fortunate position to possess certain points of reference enabling him to set up his programme of work in bold outlines.
  • US EPA, Pesticide Product Label, EVERGREEN PYRETHRUM

    US EPA, Pesticide Product Label, EVERGREEN PYRETHRUM

    UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, DC 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION April 19, 2017 Steven K. Ditto McLaughlin Gormley King Company D/B/A MGK 8810 10th Ave. N Minneapolis, MN 55427 Subject: Notification per PRN 98-10 – Revised Dilution Directions Product Name: EVERGREEN PYRETHRUM CONCENTRATE EPA Registration Number: 1021-2560 Application Date: 3/24/2017 Decision Number: 527604 Dear Mr. Ditto: The Agency is in receipt of your Application for Pesticide Notification under Pesticide Registration Notice (PRN) 98-10 for the above referenced product. The Registration Division (RD) has conducted a review of this request for its applicability under PRN 98-10 and finds that the action requested falls within the scope of PRN 98-10. The label submitted with the application has been stamped “Notification” and will be placed in our records. Should you wish to add/retain a reference to the company’s website on your label, then please be aware that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide Act and is subject to review by the Agency. If the website is false or misleading, the product would be misbranded and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) list examples of statements EPA may consider false or misleading. In addition, regardless of whether a website is referenced on your product’s label, claims made on the website may not substantially differ from those claims approved through the registration process. Therefore, should the Agency find or if it is brought to our attention that a website contains false or misleading statements or claims substantially differing from the EPA approved registration, the website will be referred to the EPA’s Office of Enforcement and Compliance.
  • Managing Pesticide Poisoning Risk and Understanding the Signs and Symptoms Clyde L

    Managing Pesticide Poisoning Risk and Understanding the Signs and Symptoms Clyde L

    EC2505 Revised June 2018 Managing Pesticide Poisoning Risk and Understanding the Signs and Symptoms Clyde L. Ogg, Extension Educator Jan R. Hygnstrom, Project Manager Cheryl A. Alberts, Project Coordinator Erin C. Bauer, Entomology Lecturer The potential for accidents with pesticides is real. Ac- cidental exposure or overexposure to pesticides can have seri- ous consequences. While most pesticides can be used with relatively little risk when label directions are followed, some are extremely toxic and require special precautions. The Poison Control Centers receive about 90,000 calls each year related to pesticide exposures. Pesticides are re- sponsible for about 3 percent of all accidental exposures to children 5 years and younger and about 4 percent for adults. In addition, pesticides are the cause of about 3 percent of children’s deaths reported to the Poison Control Centers. Routes of Exposure Pesticides can enter the human body three ways: 1) der- mal exposure, by absorption through the skin or eyes; 2) oral exposure, through the mouth; and 3) through inhalation or respiratory exposure, by inhaling into the lungs. Some classify exposure through the eyes as ocular exposure. Dermal exposure results in absorption immediately after Figure 1. Absorption rates of different a pesticide contacts the skin or eyes. Absorption will contin- parts of the body based on the absorption ue as long as the pesticide remains in contact with the skin or of parathion into the forearm over 24 eyes. The rate at which dermal absorption occurs is different hours. for each part of the body (Figure 1). Maiback and Feldman (1974) measured the amount of the pesticide parathion absorbed by different parts of the human body over 24 hours.