H2AFB1 Polyclonal Antibody (Catalog # A62726)

EPIGENTEK USA Tel: 1-877-374-4368 Int. Tel: 1-718-484-3990 Complete Solutions for Epigenetics [email protected] www.epigentek.com H2AFB1 Polyclonal Antibody (Catalog # A62726) Background Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. Description H2AFB1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit. Formulation Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4. Specificity Human Isotype IgG Uniprot ID P0C5Y9 Purification >95%, Protein G purified Immunogen Recombinant Human Histone H2A-Bbd type 1 protein (1-115AA) Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze. Alternative Names Histone H2A-Bbd type 1, H2A Barr body-deficient, H2A.Bbd, H2AFB1 Application ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 This product is for research purposes only. Not intended for use in diagnostic procedures. 2020-11-19-A62726 Immunohistochemistry of paraffin-embedded human liver tissue using H2AFB1 Polyclonal Antibody at dilution of 1:100 Immunofluorescent analysis of MCF-7 cells using H2AFB1 Polyclonal Antibody at a dilution of 1:100 and Alexa Fluor 488- congugated AffiniPure Goat Anti-Rabbit IgG (H+L) This product is for research purposes only. Not intended for use in diagnostic procedures. 2020-11-19-A62726 .

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A Computational Approach for Defining a Signature of Β-Cell Golgi Stress in Diabetes Mellitus
Page 1 of 781 Diabetes A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus Robert N. Bone1,6,7, Olufunmilola Oyebamiji2, Sayali Talware2, Sharmila Selvaraj2, Preethi Krishnan3,6, Farooq Syed1,6,7, Huanmei Wu2, Carmella Evans-Molina 1,3,4,5,6,7,8* Departments of 1Pediatrics, 3Medicine, 4Anatomy, Cell Biology & Physiology, 5Biochemistry & Molecular Biology, the 6Center for Diabetes & Metabolic Diseases, and the 7Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; 2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202; 8Roudebush VA Medical Center, Indianapolis, IN 46202. *Corresponding Author(s): Carmella Evans-Molina, MD, PhD ([email protected]) Indiana University School of Medicine, 635 Barnhill Drive, MS 2031A, Indianapolis, IN 46202, Telephone: (317) 274-4145, Fax (317) 274-4107 Running Title: Golgi Stress Response in Diabetes Word Count: 4358 Number of Figures: 6 Keywords: Golgi apparatus stress, Islets, β cell, Type 1 diabetes, Type 2 diabetes 1 Diabetes Publish Ahead of Print, published online August 20, 2020 Diabetes Page 2 of 781 ABSTRACT The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We utilized an informatics-based approach to develop a transcriptional signature of β-cell GA stress using existing RNA sequencing and microarray datasets generated using human islets from donors with diabetes and islets where type 1(T1D) and type 2 diabetes (T2D) had been modeled ex vivo. To narrow our results to GA-specific genes, we applied a filter set of 1,030 genes accepted as GA associated.
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