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Blood Glucose Response After Oral Lactulose Intake in Type 2 Diabetic

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Blood Glucose Response After Oral Lactulose Intake in Type 2 Diabetic ISSN 1948-9358 (online) World Journal of Diabetes World J Diabetes 2021 June 15; 12(6): 685-915 Published by Baishideng Publishing Group Inc World Journal of W J D Diabetes Contents Monthly Volume 12 Number 6 June 15, 2021 REVIEW 685 Role of novel biomarkers in diabetic cardiomyopathy Kumric M, Ticinovic Kurir T, Borovac JA, Bozic J 706 Critical review of bone health, fracture risk and management of bone fragility in diabetes mellitus Palui R, Pramanik S, Mondal S, Ray S 730 Mechanisms linking gut microbial metabolites to insulin resistance Jang HR, Lee HY 745 Alzheimer’s disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links Rojas M, Chávez-Castillo M, Bautista J, Ortega Á, Nava M, Salazar J, Díaz-Camargo E, Medina O, Rojas-Quintero J, Bermúdez V MINIREVIEWS 767 Diabetes and inflammatory diseases: An overview from the perspective of Ca2+/3'-5'-cyclic adenosine monophosphate signaling Bergantin LB 780 Effect of COVID-19 on management of type 1 diabetes: Pushing the boundaries of telemedical healthcare Bilic Curcic I, Cigrovski Berkovic M, Kizivat T, Canecki Varzic S, Smolic R, Smolic M 786 Oral glucose tolerance test in diabetes, the old method revisited Kuo FY, Cheng KC, Li Y, Cheng JT 794 Diabetic gastroenteropathy: An underdiagnosed complication Concepción Zavaleta MJ, Gonzáles Yovera JG, Moreno Marreros DM, Rafael Robles LDP, Palomino Taype KR, Soto Gálvez KN, Arriola Torres LF, Coronado Arroyo JC, Concepción Urteaga LA 810 Endothelial impairment evaluation by peripheral arterial tonometry in pediatric endocrinopathies: A narrative review La Valle A, Crocco M, Chiarenza DS, Maghnie M, d'Annunzio G 827 Diabetes and peripheral artery disease: A review Soyoye DO, Abiodun OO, Ikem RT, Kolawole BA, Akintomide AO 839 New perspectives on angiotensin-converting enzyme 2 and its related diseases Liu LP, Zhang XL, Li J 855 Cardiovascular autonomic neuropathy in diabetes: Pathophysiology, clinical assessment and implications Duque A, Mediano MFF, De Lorenzo A, Rodrigues Jr LF WJD https://www.wjgnet.com I June 15, 2021 Volume 12 Issue 6 World Journal of Diabetes Contents Monthly Volume 12 Number 6 June 15, 2021 ORIGINAL ARTICLE Retrospective Cohort Study 868 Estimated impact of introduction of new diagnostic criteria for gestational diabetes mellitus de Wit L, Zijlmans AB, Rademaker D, Naaktgeboren CA, DeVries JH, Franx A, Painter RC, van Rijn BB Observational Study 883 Control of modifiable risk factors and major adverse cardiovascular events in people with peripheral artery disease and diabetes Golledge J, Drovandi A, Rowbotham S, Velu R, Quigley F, Jenkins J Randomized Controlled Trial 893 Blood glucose response after oral lactulose intake in type 2 diabetic individuals Pieber TR, Svehlikova E, Mursic I, Esterl T, Wargenau M, Sartorius T, Pauly L, Schwejda-Guettes S, Neumann A, Faerber V, Stover JF, Gaigg B, Kuchinka-Koch A META-ANALYSIS 908 Coffee consumption and risk of type 2 diabetes mellitus in Asians: A meta-epidemiological study of population-based cohort studies Bae JM WJD https://www.wjgnet.com II June 15, 2021 Volume 12 Issue 6 World Journal of Diabetes Contents Monthly Volume 12 Number 6 June 15, 2021 ABOUT COVER Editorial Board Member of World Journal of Diabetes, Jue Liu, MD, PhD, Associated Professor, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. [email protected] AIMS AND SCOPE The primary aim of World Journal of Diabetes (WJD, World J Diabetes) is to provide scholars and readers from various fields of diabetes with a platform to publish high-quality basic and clinical research articles and communicate their research findings online. WJD mainly publishes articles reporting research results and findings obtained in the field of diabetes and covering a wide range of topics including risk factors for diabetes, diabetes complications, experimental diabetes mellitus, type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes, diabetic angiopathies, diabetic cardiomyopathies, diabetic coma, diabetic ketoacidosis, diabetic nephropathies, diabetic neuropathies, Donohue syndrome, fetal macrosomia, and prediabetic state. INDEXING/ABSTRACTING The WJD is now abstracted and indexed in Science Citation Index Expanded (SCIE, also known as SciSearch®), Current Contents/Clinical Medicine, Journal Citation Reports/Science Edition, PubMed, and PubMed Central. The 2020 Edition of Journal Citation Reports® cites the 2019 impact factor (IF) for WJD as 3.247; IF without journal self cites: 3.222; Ranking: 70 among 143 journals in endocrinology and metabolism; and Quartile category: Q2. RESPONSIBLE EDITORS FOR THIS ISSUE Production Editor: Yu-Jie Ma; Production Department Director: Xiang Li; Editorial Office Director: Jia-Ping Yan. NAME OF JOURNAL INSTRUCTIONS TO AUTHORS World Journal of Diabetes https://www.wjgnet.com/bpg/gerinfo/204 ISSN GUIDELINES FOR ETHICS DOCUMENTS ISSN 1948-9358 (online) https://www.wjgnet.com/bpg/GerInfo/287 LAUNCH DATE GUIDELINES FOR NON-NATIVE SPEAKERS OF ENGLISH June 15, 2010 https://www.wjgnet.com/bpg/gerinfo/240 FREQUENCY PUBLICATION ETHICS Monthly https://www.wjgnet.com/bpg/GerInfo/288 EDITORS-IN-CHIEF PUBLICATION MISCONDUCT Timothy Koch https://www.wjgnet.com/bpg/gerinfo/208 EDITORIAL BOARD MEMBERS ARTICLE PROCESSING CHARGE https://www.wjgnet.com/1948-9358/editorialboard.htm https://www.wjgnet.com/bpg/gerinfo/242 PUBLICATION DATE STEPS FOR SUBMITTING MANUSCRIPTS June 15, 2021 https://www.wjgnet.com/bpg/GerInfo/239 COPYRIGHT ONLINE SUBMISSION © 2021 Baishideng Publishing Group Inc https://www.f6publishing.com © 2021 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA E-mail: [email protected] https://www.wjgnet.com WJD https://www.wjgnet.com III June 15, 2021 Volume 12 Issue 6 World Journal of W J D Diabetes Submit a Manuscript: https://www.f6publishing.com World J Diabetes 2021 June 15; 12(6): 893-907 DOI: 10.4239/wjd.v12.i6.893 ISSN 1948-9358 (online) ORIGINAL ARTICLE Randomized Controlled Trial Blood glucose response after oral lactulose intake in type 2 diabetic individuals Thomas R Pieber, Eva Svehlikova, Ines Mursic, Tamara Esterl, Manfred Wargenau, Tina Sartorius, Lioba Pauly, Susann Schwejda-Guettes, Annalena Neumann, Valentin Faerber, John Friedrich Stover, Barbara Gaigg, Angelika Kuchinka-Koch ORCID number: Thomas R Pieber Thomas R Pieber, Eva Svehlikova, Ines Mursic, Tamara Esterl, Division of Endocrinology and 0000-0003-3554-0405; Eva Diabetology, Department of Internal Medicine, Medical University of Graz, Graz 8036, Austria Svehlikova 0000-0002-9743-2031; Ines Mursic 0000-0003-3836-6529; Manfred Wargenau, Department of Statistic, M.A.R.C.O. GmbH & Co. KG, Institute for Tamara Esterl 0000-0002-2615-680X; Clinical Research and Statistics, Düsseldorf 40211, Germany Manfred Wargenau 0000-0002-0886- 0158; Tina Sartorius 0000-0002-5264- Tina Sartorius, Department of Nutritional CRO, BioTeSys GmbH, Esslingen 73728, Germany 7207; Lioba Pauly 0000-0002-2673- 012X; Susann Schwejda-Guettes Lioba Pauly, Susann Schwejda-Guettes, Department of Medical & Clinical Affairs, Market 0000-0002-6635-6005; Annalena Access & Education Business Unit Enteral Nutrition, Bad Homburg 61352, Germany Neumann 0000-0002-9716-329X; Valentin Faerber 0000-0003-4250- Annalena Neumann, Valentin Faerber, Department of Medical, Clinical & Regulatory Affairs, 3389; John Friedrich Stover 0000- Business Unit Parenteral Nutrition, Keto-Analogues and Standard I.V. Fluids, Fresenius Kabi 0001-9457-0941; Barbara Gaigg 0000- Deutschland GmbH, Bad Homburg 61352, Germany 0002-8549-8877; Angelika Kuchinka- Koch 0000-0003-1874-1571. John Friedrich Stover, Department of Consultancy, Stover-Solutions, Zurich 8006, Switzerland Author contributions: Pieber TR, Barbara Gaigg, Angelika Kuchinka-Koch, Market Unit Lactulose, Fresenius Kabi Austria GmbH, Svehlikova E, Mursic I, and Esterl Linz 4020, Austria T performed the study, data Corresponding author: Valentin Faerber, PhD, Director, Department of Medical, Clinical & collection and interpretation; Stover JF, Pauly L, Schwejda- Regulatory Affairs, Business Unit Parenteral Nutrition, Keto-Analogues and Standard I. V. Guettes S, Kuchinka-Koch A, and Fluids, Fresenius Kabi Deutschland GmbH, Else-Kroener-Straße 1, Bad Homburg 61352, Gaigg B designed and supervised Germany. [email protected] the study; Wargenau M planned and performed the statistical analysis of the data and interpreted Abstract the results; Sartorius T, Neumann BACKGROUND A, and Faerber V wrote the Lactulose is approved for the symptomatic treatment of constipation, a gastrointe- manuscript; all authors reviewed, stinal (GI) complication common in individuals with diabetes. Lactulose products edited, and approved the contain carbohydrate impurities (e.g., lactose, fructose, galactose), which occur manuscript for submission. during the lactulose manufacturing process. These impurities may affect the blood glucose levels of individuals with type 2 diabetes mellitus (T2DM) using lactulose Supported by Fresenius Kabi for the treatment of mild constipation. A previous study in healthy subjects Deutschland GmbH, Germany. revealed no increase in blood glucose levels after oral lactulose intake. However, it is still unclear whether the intake of lactulose increases blood glucose levels in Institutional review board individuals with diabetes. WJD https://www.wjgnet.com 893 June 15, 2021 Volume 12 Issue 6 Pieber TR et al. Blood glucose after lactulose
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