Aging and Disabilit
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Monoamine Oxydases Et Athérosclérose : Signalisation Mitogène Et Études in Vivo
UNIVERSITE TOULOUSE III - PAUL SABATIER Sciences THESE Pour obtenir le grade de DOCTEUR DE L’UNIVERSITE TOULOUSE III Discipline : Innovation Pharmacologique Présentée et soutenue par : Christelle Coatrieux le 08 octobre 2007 Monoamine oxydases et athérosclérose : signalisation mitogène et études in vivo Jury Monsieur Luc Rochette Rapporteur Professeur, Université de Bourgogne, Dijon Monsieur Ramaroson Andriantsitohaina Rapporteur Directeur de Recherche, INSERM, Angers Monsieur Philippe Valet Président Professeur, Université Paul Sabatier, Toulouse III Madame Nathalie Augé Examinateur Chargé de Recherche, INSERM Monsieur Angelo Parini Directeur de Thèse Professeur, Université Paul Sabatier, Toulouse III INSERM, U858, équipes 6/10, Institut Louis Bugnard, CHU Rangueil, Toulouse Résumé Les espèces réactives de l’oxygène (EROs) sont impliquées dans l’activation de nombreuses voies de signalisation cellulaires, conduisant à différentes réponses comme la prolifération. Les EROs, à cause du stress oxydant qu’elles génèrent, sont impliquées dans de nombreuses pathologies, notamment l’athérosclérose. Les monoamine oxydases (MAOs) sont deux flavoenzymes responsables de la dégradation des catécholamines et des amines biogènes comme la sérotonine ; elles sont une source importante d’EROs. Il a été montré qu’elles peuvent être impliquées dans la prolifération cellulaire ou l’apoptose du fait du stress oxydant qu’elles génèrent. Ce travail de thèse a montré que la MAO-A, en dégradant son substrat (sérotonine ou tyramine), active une voie de signalisation mitogène particulière : la voie métalloprotéase- 2/sphingolipides (MMP2/sphingolipides), et contribue à la prolifération de cellules musculaire lisses vasculaires induite par ces monoamines. De plus, une étude complémentaire a confirmé l’importance des EROs comme stimulus mitogène (utilisation de peroxyde d’hydrogène exogène), et a décrit plus spécifiquement les étapes en amont de l’activation de MMP2, ainsi que l’activation par la MMP2 de la sphingomyélinase neutre (première enzyme de la cascade des sphingolipides). -
Transport of Dangerous Goods
ST/SG/AC.10/1/Rev.16 (Vol.I) Recommendations on the TRANSPORT OF DANGEROUS GOODS Model Regulations Volume I Sixteenth revised edition UNITED NATIONS New York and Geneva, 2009 NOTE The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. ST/SG/AC.10/1/Rev.16 (Vol.I) Copyright © United Nations, 2009 All rights reserved. No part of this publication may, for sales purposes, be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, electrostatic, magnetic tape, mechanical, photocopying or otherwise, without prior permission in writing from the United Nations. UNITED NATIONS Sales No. E.09.VIII.2 ISBN 978-92-1-139136-7 (complete set of two volumes) ISSN 1014-5753 Volumes I and II not to be sold separately FOREWORD The Recommendations on the Transport of Dangerous Goods are addressed to governments and to the international organizations concerned with safety in the transport of dangerous goods. The first version, prepared by the United Nations Economic and Social Council's Committee of Experts on the Transport of Dangerous Goods, was published in 1956 (ST/ECA/43-E/CN.2/170). In response to developments in technology and the changing needs of users, they have been regularly amended and updated at succeeding sessions of the Committee of Experts pursuant to Resolution 645 G (XXIII) of 26 April 1957 of the Economic and Social Council and subsequent resolutions. -
Silybum Marianum (Milk Thistle) Flower in Vitro and on Human Explants
Molecules 2015, 20, 3549-3564; doi:10.3390/molecules20033549 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Article Anti-Glycation Activities of Phenolic Constituents from Silybum marianum (Milk Thistle) Flower in Vitro and on Human Explants Seoungwoo Shin, Jung-A Lee, Minkyung Kim, Hyunwoo Kum, Eunsun Jung * and Deokhoon Park * Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seoungnam City, Gyunggi Do 462-807, Korea; E-Mails: [email protected] (S.S.); [email protected] (J.-A.L.); [email protected] (M.K.); [email protected] (H.K.) * Authors to whom correspondence should be addressed; E-Mails: [email protected] (E.J.); [email protected] (D.P.); Tel.: +82-31-750-9400 (E.J. & D.P.); Fax: +82-31-750-9494 (E.J. & D.P.). Academic Editor: Derek J. McPhee Received: 25 November 2014 / Accepted: 15 February 2015 / Published: 19 February 2015 Abstract: Glycation is an ageing reaction of naturally occurring sugars with dermal proteins, with clinical signs appearing in vivo around age 30, and increasing steadily/regularly with age. The suppleness of the dermis is affected by the formation of bridges between proteins and sugars (Maillard’s reaction). The accumulation of advanced glycation end products (AGEs) in skin plays a very important role in skin ageing. Therefore, natural compounds or extracts that possess antiglycation activities may have great anti-ageing potential. In the present study, Silybum marianum flower extract (SMFE) was demonstrated to possess antiglycation activity. We found that SMFE inhibits glycation reaction between BSA and glucose. In addition, antiglycation activity of SMFE was confirmed in a human skin explants model. -
2014 Durham Ponds Assessment and Plan
DK Water Resource Consulting LLC Prepared for: Prepared by: VHB DK WRC LLC April 2014 45 Red Brook Circle Wolfeboro, NH 03894 Mill Pond Durham Ponds Assessment and Plan Beards Pond Little Hale Pond i Durham Ponds Assessment and Plan _________________________________ Prepared By: Don Kretchmer CLM DK Water Resource Consulting LLC ii Contents Executive Summary ................................................................................................................. v 1.0 Introduction ................................................................................................................... 1-1 2.0 Water Quality and Ecology of the Ponds .................................................................... 2-1 3.0 LLRM Model of Current Conditions ............................................................................ 3-1 3.1 Nutrient Inputs...................................................................................................................... 3-2 3.2 Phosphorus Loading Assessment Summary ..................................................................... 3-4 3.3 Phosphorus Loading Assessment Limitations.................................................................... 3-4 3.4 Lake Response to Current Phosphorus Loads .................................................................. 3-5 3.5 Reduction Needed ............................................................................................................... 3-6 4.0 Potential Management Options .................................................................................. -
Toxicological Profile for Hydrazines. US Department Of
TOXICOLOGICAL PROFILE FOR HYDRAZINES U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry September 1997 HYDRAZINES ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. HYDRAZINES iii UPDATE STATEMENT Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333 HYDRAZINES vii CONTRIBUTORS CHEMICAL MANAGER(S)/AUTHOR(S): Gangadhar Choudhary, Ph.D. ATSDR, Division of Toxicology, Atlanta, GA Hugh IIansen, Ph.D. ATSDR, Division of Toxicology, Atlanta, GA Steve Donkin, Ph.D. Sciences International, Inc., Alexandria, VA Mr. Christopher Kirman Life Systems, Inc., Cleveland, OH THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS: 1 . Green Border Review. Green Border review assures the consistency with ATSDR policy. 2 . Health Effects Review. The Health Effects Review Committee examines the health effects chapter of each profile for consistency and accuracy in interpreting health effects and classifying end points. 3. Minimal Risk Level Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. HYDRAZINES ix PEER REVIEW A peer review panel was assembled for hydrazines. The panel consisted of the following members: 1. Dr. -
Synthetic and Naturally Occurring Hydrazines As Possible Cancer Causative Agents
[CANCER RESEARCH 35, 3693-3697 December 1975] Synthetic and Naturally Occurring Hydrazines as Possible Cancer Causative Agents Bela Toth' The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68105 SUMMARY SYNTHETIC HYDRAZINES The various synthetic substituted hydrazines, which cause tumors in animals, are briefly enumerated. To date, 19 of Studies on the carcinogenic potentialities of synthetic them have proved to be tumorigenic in animals. A number substituted hydrazines began in 1962, when it was shown of these chemicals are found today in the environment, in that the base compound hydrazine sulfate induced lung industry, in agriculture, and in medicine, and the human neoplasms in mice (1). Subsequently, a series of hydrazine population is exposed to a certain degree to some of them. derivatives were investigated in various laboratories for Hydrazine also occurs in nature in tobacco and tobacco tumor-inducing capabilities. These studies clearly demon smoke. The three other naturally occurring hydrazine strated that these chemicals are indeed powerful tumori compounds are N-methyl-N-formylhydrazine, which oc genic substances in mice, hamsters, and rats, due to their curs in the wild edible mushroom, Gyromitra esculenta, tumor-inducing abilities in the intestines, brain, lungs, and @-N-[―y-L(+)-glutamylJ-4-hydroxymethylphenyl blood vessels, liver, breasts, kidneys, etc. Now, we know of hydrazine and 4-hydroxymethylphenylhydrazine, whkh 19 hydrazine derivatives that have been shown to be tumor are found in the commonly eaten cultivated mushroom, inducers. These include, in addition to hydrazine (1, 32), Agaricus bisporus. Tumorigenesis studies with the natu methyl- (35, 40), 1,2-dimethyl- (6, 27, 36, 46, 52), 1,1- rally occurring hydrazines are in progress. -
Environmental Protection Planopens in New Window
Copy No: ENVIRONMENTAL PROTECTION PLAN FOR THE DUCK POND COPPER-ZINC PROJECT Prepared for: Aur Resources Inc. 30-32, Route 370, Box 9 Millertown, NL A0H 1V0 Prepared by: Jacques Whitford 607 Torbay Road St. John’s, NL A1A 4Y6 November 2004 Environmental Protection Plan Duck Pond Copper-Zinc Project Table of Contents Page i TABLE OF CONTENTS Page No. TABLE OF CONTENTS................................................................................................................i DISTRIBUTION LIST ................................................................................................................ iii 1 INTRODUCTION..........................................................................................................................1 1.1 Purpose of the EPP..............................................................................................................1 1.2 Organization of the EPP......................................................................................................2 1.3 Environmental Orientation ..................................................................................................3 1.4 Aur Policy ...........................................................................................................................4 1.5 Project Description..............................................................................................................5 1.5.1 Paste Backfill Preparation Plant.............................................................................5 1.5.2 Turf Point -
Receptor Antagonist
Europäisches Patentamt *EP001604983A1* (19) European Patent Office Office européen des brevets (11) EP 1 604 983 A1 (12) EUROPEAN PATENT APPLICATION published in accordance with Art. 158(3) EPC (43) Date of publication: (51) Int Cl.7: C07D 217/26, C07D 403/06, 14.12.2005 Bulletin 2005/50 C07D 403/12, C07D 491/113, A61K 31/472, A61K 31/4741, (21) Application number: 04721010.9 A61P 43/00, A61P 29/00, (22) Date of filing: 16.03.2004 A61P 35/00, A61P 15/00, A61P 15/08, A61P 15/10, A61P 15/14, A61P 37/00, A61P 5/48, A61P 3/10, A61P 3/02, A61P 3/06, A61P 17/00, A61P 19/02, A61P 19/08 (86) International application number: PCT/JP2004/003496 (87) International publication number: WO 2004/083184 (30.09.2004 Gazette 2004/40) (84) Designated Contracting States: • HINUMA, Shuji AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Tsukuba-shi, Ibaraki 3050821 (JP) HU IE IT LI LU MC NL PL PT RO SE SI SK TR • KANZAKI, Naoyuki, c/o Takeda Pharmaceutical Designated Extension States: Yodogawa-ku, Osaka-shi, Osaka (JP) AL LT LV MK • BANNO, Yoshihiro, c/o Takeda Pharmaceutical Yodogawa-ku, Osaka-shi, Osaka (JP) (30) Priority: 17.03.2003 JP 2003072709 • YOSHIDA, Hiromi Yuki-gun, Ibar aki 3002741 (JP) (71) Applicant: Takeda Pharmaceutical Company • MATSUMOTO, Hirokazu Limited Tsukuba-shi, Ibaraki 3050821 (JP) Osaka 541-0045 (JP) (74) Representative: Rickard, Timothy Mark Adrian (72) Inventors: Takeda Euro IP Department, • ITOH, Fumio 11-12 Charles II Street Tsukuba-shi, Ibaraki 3050821 (JP) London SW1Y 4QU (GB) (54) RECEPTOR ANTAGONIST (57) A compound represented by -
Innovative Waste Water Strategies in the Landscape
University of Massachusetts Amherst ScholarWorks@UMass Amherst Landscape Architecture & Regional Planning Landscape Architecture & Regional Planning Masters Projects 10-2017 Innovative Waste Water Strategies in the Landscape: The Application of Green Infrastructure Principles in Cape Cod, Massachusetts Kellie Fenton University of Massachusetts Amherst, [email protected] Follow this and additional works at: https://scholarworks.umass.edu/larp_ms_projects Part of the Landscape Architecture Commons, and the Urban Studies and Planning Commons Fenton, Kellie, "Innovative Waste Water Strategies in the Landscape: The Application of Green Infrastructure Principles in Cape Cod, Massachusetts" (2017). Landscape Architecture & Regional Planning Masters Projects. 88. Retrieved from https://scholarworks.umass.edu/larp_ms_projects/88 This Article is brought to you for free and open access by the Landscape Architecture & Regional Planning at ScholarWorks@UMass Amherst. It has been accepted for inclusion in Landscape Architecture & Regional Planning Masters Projects by an authorized administrator of ScholarWorks@UMass Amherst. For more information, please contact [email protected]. Innovative Waste Water Strategies in the Landscape: The application of green infrastructure principles in Cape Cod, Massachusetts Kellie Fenton Masters in Landscape Architecture Department of Landscape Architecture and Regional Planning University of Massachusetts, Amherst Innovative Waste Water Strategies in the Landscape: The application of green infrastructure -
Data Review and Evaluation of Groundwater Monitoring White Mesa Uranium Mill Blanding Utah
DATA REVIEW AND EVALUATION OF GROUNDWATER MONITORING WHITE MESA URANIUM MILL BLANDING UTAH AUGUST 2015 PROJECT NO. 2015.A025 PREPARED FOR: Ute Mountain Ute Tribe P.O. Box 448 Towaoc, CO 81334 PREPARED BY: Geo-Logic Associates 1760 E. River Road, Suite 115 Tucson, AZ 85718 Data Review and Evaluation of Groundwater Monitoring White Mesa Uranium Mill, Blanding Utah TABLE OF CONTENTS 1.0 INTRODUCTION .......................................................................................................... 1 2.0 FACILITY DESCRIPTION AND HISTORY ......................................................................... 1 3.0 DATA ANALYSIS .......................................................................................................... 6 3.1 Hydrogeologic Conditions ....................................................................................... 6 3.1.1 Climate ........................................................................................................ 7 3.1.2 Topography ................................................................................................. 7 3.1.3 Local Stratigraphy ....................................................................................... 7 3.1.4 Groundwater Occurrence ........................................................................... 9 3.1.5 Water Level Changes ................................................................................ 12 3.1.6 Hydraulic Properties ................................................................................. 20 3.1.7 Groundwater -
Merrymeeting River & Lake
MERRYMEETING RIVER & LAKE WATERSHED MANAGEMENT PLAN FOR THE CYANOBACTERIA MITIGATION STEERING COMMITTEE OF NEW DURHAM/ALTON [FINAL September 2019] FB ENVIRONMENTAL ASSOCIATES 170 West Road, Suite 6 Portsmouth, NH 03801 www.fbenvironmental.com © John Gisis MERRYMEETING RIVER & LAKE WATERSHED MANAGEMENT PLAN FB Environmental Associates ii MERRYMEETING RIVER & LAKE WATERSHED MANAGEMENT PLAN MERRYMEETING RIVER & LAKE WATERSHED MANAGEMENT PLAN Prepared by FB ENVIRONMENTAL ASSOCIATES in cooperation with the Cyanobacteria Mitigation Steering Committee of New Durham/Alton, DK Water Resource Consulting, and Horsley Witten Group FINAL | September 2019 CONTACT Cyanobacteria Mitigation Steering Committee of New Durham/Alton P.O. Box 243 New Durham, NH 03855 Funding for this project was provided by the towns of New Durham and Alton, New Hampshire. FB Environmental Associates iii MERRYMEETING RIVER & LAKE WATERSHED MANAGEMENT PLAN EXECUTIVE SUMMARY According to the 303(d) New Hampshire List of Impaired Waters, Marsh, Jones, and Downing Ponds are impaired for primary contact recreation due to elevated levels of cyanobacteria hepatotoxic microcystins. Toxic cyanobacteria blooms are often indicative of enhanced nutrient loading, particularly phosphorus, from point source (PS) and nonpoint source (NPS) pollution such as stormwater runoff from developed and agricultural land uses. In this case, point source discharges from the Powder Mill State Fish Hatchery are estimated to contribute 342 kg P/yr (67% of the total load) to the river as it flows into Marsh Pond. Local groups and town officials are working with state and federal agencies to set an appropriate phosphorus load discharge limit for the Powder Mill State Fish Hatchery; this permitted limit will dictate the achievable in-pond concentrations for Marsh, Jones, and Downing Ponds, and thus, the water quality goals described herein should be considered preliminary. -
Detailed Species Accounts from The
Threatened Birds of Asia: The BirdLife International Red Data Book Editors N. J. COLLAR (Editor-in-chief), A. V. ANDREEV, S. CHAN, M. J. CROSBY, S. SUBRAMANYA and J. A. TOBIAS Maps by RUDYANTO and M. J. CROSBY Principal compilers and data contributors ■ BANGLADESH P. Thompson ■ BHUTAN R. Pradhan; C. Inskipp, T. Inskipp ■ CAMBODIA Sun Hean; C. M. Poole ■ CHINA ■ MAINLAND CHINA Zheng Guangmei; Ding Changqing, Gao Wei, Gao Yuren, Li Fulai, Liu Naifa, Ma Zhijun, the late Tan Yaokuang, Wang Qishan, Xu Weishu, Yang Lan, Yu Zhiwei, Zhang Zhengwang. ■ HONG KONG Hong Kong Bird Watching Society (BirdLife Affiliate); H. F. Cheung; F. N. Y. Lock, C. K. W. Ma, Y. T. Yu. ■ TAIWAN Wild Bird Federation of Taiwan (BirdLife Partner); L. Liu Severinghaus; Chang Chin-lung, Chiang Ming-liang, Fang Woei-horng, Ho Yi-hsian, Hwang Kwang-yin, Lin Wei-yuan, Lin Wen-horn, Lo Hung-ren, Sha Chian-chung, Yau Cheng-teh. ■ INDIA Bombay Natural History Society (BirdLife Partner Designate) and Sálim Ali Centre for Ornithology and Natural History; L. Vijayan and V. S. Vijayan; S. Balachandran, R. Bhargava, P. C. Bhattacharjee, S. Bhupathy, A. Chaudhury, P. Gole, S. A. Hussain, R. Kaul, U. Lachungpa, R. Naroji, S. Pandey, A. Pittie, V. Prakash, A. Rahmani, P. Saikia, R. Sankaran, P. Singh, R. Sugathan, Zafar-ul Islam ■ INDONESIA BirdLife International Indonesia Country Programme; Ria Saryanthi; D. Agista, S. van Balen, Y. Cahyadin, R. F. A. Grimmett, F. R. Lambert, M. Poulsen, Rudyanto, I. Setiawan, C. Trainor ■ JAPAN Wild Bird Society of Japan (BirdLife Partner); Y. Fujimaki; Y. Kanai, H.