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Congress Abstract Book XIIth Congress of the International Society of Bone Morphometry October 16-19, 2012 Sheraton Minneapolis West Minneapolis, Minnesota www.conference.ifas.ufl.edu/isbm October 16-19, 2012 Minneapolis, Minnesota, USA Welcome to the XIIth Congress of the International Society of Bone Morphometry! ISBM is a non-profit organization that has its origins in a series of workshops on bone morphometry, the first of which was held in Ottawa in 1973. The core mission of ISBM is to emphasize the importance of traditional morphometric techniques in the field of bone research. ISBM also embraces new technologies that result in refinements and advances in bone morphometric analyses, and facilitates education and training in all aspects of bone morphometry. Many preclinical and clinical studies utilize bone morphometry as an essential technique to assess changes in bone structure and levels of bone formation and resorption in response to a variety of influences such as hormones, cytokines, growth factors, mechanical loading, and bone-active drugs. Bone morphometry is also essential for skeletal phenotyping of knockout and transgenic mice. The scientific program consists of invited talks by prominent investigators in the areas of osteoporosis treatments, bone imaging, bone cancer, bone fracture healing, bone biomechanics, and bone implants. These talks will be followed in each session by oral presentations of the most highly-scored abstracts. Poster presentations will also be available for viewing throughout the Congress. Ample time will be available for discussions of the findings of the investigators. The Congress will conclude with a practical training session on proper use of bone morphometric techniques, primarily in rodent models. The social program consists of an opening reception before the keynote address, an evening excursion to the legendary Mall of America for interested attendees, and a dinner cruise on beautiful Lake Minnetonka aboard the Queen of Excelsior. The amiable, intimate environment of the ISBM Congress is conducive to interactions among scientists that promote research collaborations. This Congress would not be possible without the generosity of our sponsors and exhibitors. Special thanks are in order for Ms. Holly Paszko, the Congress Coordinator, for her outstanding organizational efforts. Thanks very much for attending, and I hope that you find the ISBM Congress to be a rewarding educational experience, and enjoyable as well! Thomas J. Wronski Professor and President, ISBM i XIIth Congress of the International Society of Bone Morphometry ii October 16-19, 2012 Minneapolis, Minnesota, USA Table of Contents Welcome Letter .......................................................................... i Officers and Board Members..................................................... v Scientific Program Committee ................................................... v Sponsor & Exhibitor Recognition ............................................. vii Congress Agenda .................................................................... ix Poster Directory ..................................................................... xiii Congress Abstracts .................................................................. 1 Author Index ........................................................................... 55 Notes ..................................................................................... 58 iii XIIth Congress of the International Society of Bone Morphometry iv October 16-19, 2012 Minneapolis, Minnesota, USA Officers and Board Members of of the International Society of Bone Morphometry President: Thomas Wronski Past President: Reinhold Erben Treasurer: Brendan Boyce Board Members: Jillian Cornish Donald Kimmel Michaela Kneissel Brendon Noble Masaki Noda Natalie Sims Scientific Program Committee Thomas Wronski (Chair) Ignacio Aguirre Matthew Allen Susan Bloomfield Steven Boyd Diane Cullen Christopher Hernandez Urszula Iwaniec Laurie McCauley Paul Roschger Rick Sumner Sara Windhal Wei Yao v XIIth Congress of the International Society of Bone Morphometry vi October 16-19, 2012 Minneapolis, Minnesota, USA A Special Thank You to our Congress Sponsors and Exhibitors GOLD SPONSORS: Amgen Lilly SILVER SPONSORS: Merck OsteoMetrics Warner Chilcott BRONZE SPONSORS: The American Society for Bone and Mineral Research Bruker MicroCT International Bone & Mineral Society PharmaLegacy Ratoc CONGRESS EXHIBITORS: OsteoMetrics Scanco Medical PharmaLegacy Micro Photonics Inc. vii XIIth Congress of the International Society of Bone Morphometry viii October 16-19, 2012 Minneapolis, Minnesota, USA Congress Agenda Tuesday, October 16, 2012 4:00pm-8:00pm Pre-Conference Registration Open (Calhoun) 4:00pm-7:00pm Poster Presenter Setup (Minnesota Ballroom) 6:00pm-7:15pm Opening Reception (Poolside) 7:30pm-8:30pm Keynote Address: Robert Recker, M.D. Bone Morphometry in Evaluation of Osteoporosis Therapies (Minnesota Ballroom) Wednesday, October 17, 2012 7:30am-5:00pm Registration Open (Calhoun) 7:30am-10:30am Poster Presenter Setup (Minnesota Ballroom) 7:30am-8:30am Morning Refreshments / Poster Viewing (Minnesota Ballroom) 8:30am-10:00am Session 1 (Minnesota Ballroom) Chairs: Roland Baron and Masaki Noda 8:30am-9:00am Invited Speaker: Roland Baron, D.D.S., Ph.D. Osteoporosis Treatment: Challenges and Mechanisms of Action of Emerging Therapies 9:00am-9:15am Wei Yao: Reversing Bone Loss by Directing Mesenchymal Stem Cells to the Bone 9:15am-9:30am Chaoyang Li: Sclerostin Antibody Enhanced Modeling-based Bone Formation in Both Rats and Cynomolgus Monkeys 9:30am-9:45am Rachelle Johnson: Conditional Deletion of Gp130 in Osteoblasts and Osteocytes has Divergent Effects on Trabecular and Cortical Bone 9:45am-10:00am Stephen Tonna: EphrinB2 is Required for Support of Osteoclast Formation by Osteoblasts and Chondrocytes 10:00am-10:30am Mid-Morning Refreshment Break / Poster Viewing (Minnesota Ballroom) 10:30am-12:00pm Session 2 (Minnesota Ballroom) Chairs: Michaela Kneissel and David Rowe 10:30am-11:00am Invited Speaker: David Rowe, M.D. Recent Advances in Imaging of Bone and Cartilage 11:00am-11:15am Seung-Hyun Hong: An Update on Automated 2D Bone Histomorphometry 11:15am-11:30am Andreas Roschger: Combination of Quantitative Backscattered Electron Imaging with Confocal Laser Microscopy: A Powerful Tool for the Evaluation of Bone Matrix Mineralization Kinetics 11:30am-11:45am Donald Kimmel: Quantitative Comparison of Human and Mouse Trabecular Bone Ultrastructure by 3D Imaging 11:45am-12:00pm Philip Salmon: Comparison of High with Low Resolution Micro-CT Morphometry of Murine Trabecular Bone to Assess how Segmentation Methods Influence Analysis Results 12:00pm-12:15pm Presentation of ISBM Travel Awards for Young Investigators 12:15pm-1:30pm Boxed Lunch (Poolside) & Poster Viewing (Minnesota Ballroom) ix XIIth Congress of the International Society of Bone Morphometry Wednesday, October 17, 2012 (continued) 1:30pm-3:00pm Session 3 (Minnesota Ballroom) Chairs: Brendan Boyce and Laurie McCauley 1:30pm-2:00pm Invited Speaker: Laurie McCauley, D.D.S., Ph.D. Bone Cancer: Dissecting the Role of Myeloid Lineage Cells in Prostate Cancer Skeletal Metastasis 2:00pm-2:15pm Urszula Iwaniec: Low Calcium Intake Increases 4T1 Breast Cell Tumor Growth in Bone and Metastasis to Lung in Mice 2:15pm-2:30pm Francesca Salamanna: Electrochemotherapy in Bone Metastases 2:30pm-2:45pm Susanta Hui: Assessment of Bone Mineral Kinetics Following Exposure to Therapeutic Radiation 2:45pm-3:00pm Russell Turner: Effects of Marrow Transplantation on Bone Architecture and Turnover 3:00pm-3:30pm Afternoon Refreshment Break / Poster Viewing (Minnesota Ballroom) 3:30pm-5:00pm Session 4 (Minnesota Ballroom) Chairs: David Burr and Natalie Sims 3:30pm-4:00pm Invited Speaker: David Burr, Ph.D. Morphometric and Biomechanical Assessment of Skeletal Fragility 4:00pm-4:15pm Floor Lambers: Three-Dimensional Fluorescence Imaging of Microdamage Events in Cancellous Bone 4:15pm-4:30pm Robert Ritchie: Multi-Scale Characterization of the Fracture Resistance of Human Cortical Bone and its Biological Degradation Due to Aging and Disease 4:30pm-4:45pm Elizabeth Zimmermann: Multi-scale Study of Deformation and Fracture in Bone at Physiological Strain Rates 4:45pm-5:00pm Jean-Paul Roux: Association of Trabecular Bone Score (TBS) with Mechanical Behavior of Human Lumbar Vertebrae 5:00pm Adjourn 5:30pm-6:00pm Shuttle Bus to Mall of America for interested attendees Participants on their Own for the Evening Thursday, October 18, 2012 7:30am-5:00pm Registration Open (Calhoun) 7:30am-8:30am Morning Refreshments / Poster Viewing (Minnesota Ballroom) 8:30am-10:00am Session 5 (Minnesota Ballroom) Chairs: Jill Cornish and David Dempster 8:30am-9:00am Invited Speaker: David Dempster, Ph.D. Histomorphometry in Bone Disorders: Animal Models and Clinical Studies 9:00am-9:15am Yanfei Linda Ma: Cortical Histomorphometric Analyses of Teriparatide Effects in Postmenopausal Women with or Without Long-term Alendronate Therapy 9:15am-9:30am Robert Recker: Cortical Bone Behavior in Post-Menopausal Osteoporotic Women Given Hormone Replacement Therapy and/or Alendronate 9:30am-9:45am Maria-Grazia Ascenzi: Differences in Cortical Micro-structure between Hypo- and Hyper- Parathyroidism in Women x October 16-19, 2012 Minneapolis, Minnesota, USA Thursday, October 18, 2012 (continued) 9:45am-10:00am Tanja Sikjaer: PTH (1-84) Replacement Therapy in Hypoparathyroidism: Effects on Bone Metabolism and Structure 10:00am-10:30am Mid-Morning
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