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Abstracts of the ECTS Congress 2017 ECTS 2017 Calcif Tissue Int (2017) 100:S1–S174 DOI 10.1007/s00223-017-0267-2 ABSTRACTS Abstracts of the ECTS congress 2017 ECTS 2017 13–16 May 2017, Salzburg, Austria 44th European Calcified Tissue Society Congress Published online: 11 May 2017 © Springer Science+Business Media New York 2017 Committees Scientific Programme Committee Chair: Claus-C. Glu¨er (Kiel, Germany) Co-Chairs: Richard Eastell (Sheffield, UK) – Clinical Co-Chair Martina Rauner (Dresden, Germany) – New Investigator Co-Chair Hans van Leeuwen (Rotterdam, Netherlands) – Basic Science Barbara Obermayer-Pietsch (Graz, Austria) – Local Organising Co-Chair Committee Chair Anna Teti (L’Aquila, Italy) – Incoming SPC Chair Members: Miep Helfrich (Aberdeen, UK) Bente Langdahl (Aarhus, Denmark) Gudrun Stenbeck (London, UK) Lorenz Hofbauer (Dresden, Germany) Willem Lems (Amsterdam, Netherlands) Franz Jakob (Wu¨rzburg, Germany) Stuart Ralston (Edinburgh, UK) Local Organising Committee Chair: Barbara Obermayer-Pietsch (Graz, Austria) Members: Hermann Agis (Vienna, Austria) Christian Muschitz (Vienna, Austria) Felix Eckstein (Salzburg, Austria) Martina Rauner (Dresden, Germany) Abstract Review Panel Each abstract was scored blind by a minimum of seven reviewers according to the following criteria: The scientific merit of the abstract Suitable sample size Adherence to instructions Originality of work The FishBone Workshop was held on May 12, 2017 in conjunction with the ECTS Annual Congress in Salzburg. The abstracts were reviewed by the organizers of the FishBone Workshop and publication was approved by ECTS. 123 S2 Abstracts (2017) 100:S1–S174 Adele Boskey, United States of America Cyrus Cooper, United Kingdom Karl Michaëlsson, Sweden Pawel Szulc, France Adolfo Diez-Perez, Spain Daniel Grinberg, Spain Kassim Javaid, United Kingdom Peter Schwarz, Denmark Agi Grigoriadis, United Kingdom Eleftherios Paschalis, Austria Kate Ward, United Kingdom Peter Vestergaard, Denmark Alan Boyde, United Kingdom Emma Clark, United Kingdom Katharina Jähn, Germany Peyman Hadji, Germany Alfredo Cappariello, Italy Eric Hay, France Katharina Schmidt-Bleek, Germany Philippe Clezardin, France André Uitterlinden, Netherlands Eric Hesse, Germany Klaus Engelke, Germany Philippe Zysset, Switzerland Andrea Del Fattore, Italy Felicia Cosman, United States of America Klaus Klaushofer, Austria Pierre Marie, France Andrew Pitsillides, United Kingdom Fernando Gianfrancesco, Italy Lars Rejnmark, Denmark Pilar Peris, Spain Anna Teti, Italy Fernando Rivadeneira, Netherlands Laurence Legai-Mallet, France Ralph Müller, Switzerland Anna Villa, Italy Florent Elefteriou, United States of America Laurence Vico, France Richard Aspden, United Kingdom Antonella Forlino, Italy Francis Berenbaum, France Leonor Cancela, Portugal Richard Eastell, United Kingdom Antonio Rossi, Italy Franz Jakob, Germany Luigi Gennari, Italy Riko Nishimura, Japan Astrid Fahrleitner-Pammer, Austria G Harry van Lenthe, Belgium Mara Riminucci, Italy Riku Kiviranta, Finland Barbara Obermayer-Pietsch, Austria Gabri van der Pluijm, Netherlands Marcel Karperien, Netherlands Roberto Civitelli, United States of America Beate Lanske, United States of America George Nuki, United Kingdom Marius Kraenzlin, Switzerland Roger Bouillon, Belgium Ben Leder Gerhard Krönke, Germany Marjolein van Driel, Netherlands Roland Chapurlat, France Bente Langdahl, Denmark Gertrudis Carmeliet, Belgium Markus Seibel, Australia Salvatore Minisola, Italy Bess Dawson-Hughes, United States of America Graeme Campbell, Germany Martina Rauner, Germany Sandro Mazzaferro, Italy Bill Fraser, United Kingdom Gudrun Stenbeck, United Kingdom Martine Cohen-Solal, France Seiji Fukumoto, Japan Björn Busse, Germany Hanna Taipaleenmäki, Germany Mary Bouxsein, United States of America Serge Ferrari, Switzerland Bo Abrahamsen, Denmark Ingunn Holen, United Kingdom Mary Goldring, United States of America Simone Cenci, Italy Bram van der Eerden, Netherlands Irma Machuca, France Masaki Noda, Japan Steve Cummings, United States of America Brendan Boyce, United States of America Isabel Orriss, United Kingdom Matthias Hackl, Italy Steven Boyd, Canada Carmen Huesa, United Kingdom James Edwards, United Kingdom Mattia Capulli, Italy Sylvain Provot, France Carmine Settembre, Italy Jan Tuckermann, Germany Moustapha Kassem, Denmark Teun de Vries, Netherlands Carola Zillikens, Netherlands Jenneke Klein Nulend, Netherlands Nadia Rucci, Italy Thomas Link, United States of America Caroline Silve, France Jenny Gregory, United Kingdom Natalie Sims, Australia Thorsten Schinke, Germany Chantal Chenu, United Kingdom Jeroen van de Peppel, Netherlands Nick Bishop, United Kingdom Tim Arnett, United Kingdom Christian Roux, France Jochen Zwerina, Austria Nicolas Bonnet, Switzerland Tobias Bäuerle, Germany Claes Ohlsson, Sweden Johannes van Leeuwen, Netherlands Nuria Guanabens, Spain Toshio Matsumoto, Japan Claire Edwards, United Kingdom Jon Tobias, United Kingdom Olivier Peyruchaud, France Ulrike Baschant, Germany Claudine Blin-Wakkach, France Jonathan Reeve, United Kingdom Osten Ljunggren, Sweden Uwe Kornak, Germany Clemens Bergwitz, United States of America Judith Adams, United Kingdom Pamela Robey, United States of America Willem Lems, Netherlands Colin Farquharson, United States of America Juliet Compston, United Kingdom Patricia Ducy, United States of America Wim van Hul, Belgium Craig Langman, United States of America Kaare Gautvik, Norway Patrick Garnero, France Wolfgang Högler, United Kingdom Cristina Sobacchi, Italy Karl Insogna, United States of America Paul Lips, Netherlands 123 Abstracts (2017) 100:S1–S174 S3 BASIC SCIENCE UPDATE CLINICAL UPDATE Bone Biology Osteoporosis Diagnostics BU1.1 CU1.1 BONE CELL FUNCTION IN BONE AND BEYOND OSTEOPOROSIS—DIAGNOSTIC WORKUP Bram C.j. Van Der Eerden Carola Zillikens Internal Medicine, Laboratory for Calcium and Bone Metabolism, Abstract not available. Erasmus Medical Centar, Rotterdam/Netherlands Objectives: Bone cells are dynamic players in the bone marrow environment. They are responsible for the maintainance of skeletal CU1.2 homeostasis but also interact with many other cell types such as hematopietic cells, adipocytes, endothelial cells and tumor cells. FRACTURE RISK ASSESSMENT AND INTERVENTION Disturbances of their function does not only lead to osteoporosis and THRESHOLDS skeletal disorders but also impact on mineral homeostasis, hemato- Eugene McCloskey poiesis and myelodysplastic conditions, development of tumor metastases and energy development. In this lecture, the latest findings Abstract not available. will be discussed related to bone cell function and the impact this has on surrounding cell types in the skeleton and beyond. Disclosure: No significant relationships. Osteoporosis Treatment Keywords: osteocyte, mineral homeostasis, osteoblast, bone, osteoclast CU2.1 CALCIUM AND VITAMIN D Barbara Obermayer-Pietsch BU1.2 Abstract not available. BONE AND THE HAEMATOPOETIC NICHE Laura Calvi Abstract not available. CU2.2 CHOICE OF TREATMENT Adolfo Diez Perez Technology Abstract not available. BU2.1 THE IMPOSTER IN YOUR INCUBATOR: THE IMPORTANCE OF CELL LINE AUTHENTICATION AND GOOD CELL CU2.3a CULTURE PRACTICE EVIDENCE VERSUS EMINENCE: TREATMENT OF Sharon Bahia OSTEOPOROSIS IN PATIENTS WITH REDUCED KIDNEY Abstract not available. FUNCTION Erik F. Eriksen Dept. of Clinical Endocrinology, Morbid Obesity and Preventive BU2.2 Medicine, Oslo University Hospital, Oslo/Norway QUANTITATIVE PCR RESULTS REMAIN QUESTIONABLE: Objectives: Reduced kidney function affects the bone response to THE NEED FOR THE MIQE GUIDELINES treatment as well as metabolism of the treatment agent. The obejctive this review is to summarize the effects of different antiresorptive and Stephen Bustin osteoaanbolic regimens in patients with reduced kidney function Abstract not available. distinguishing between moderate and severe renal failure. Results: Due to increased risk of adverse effects on renal tubular function, bisphosphonates should not be used in patients with GFR\ 35 ml/min. However, in patients with moderate renal failure (GFR BU2.3 35–60 ml/mn) bisphosphonates, be it oral or intravenous are safe, GET THE MOST OUT OF YOUR PROBES: PROTEIN without any evidence of increased risk of adverse renal effects with DETECTION METHODS FROM IN VIVO TO IN GEL decreasing GFR. In this range the effects of bisphosphonates on BMD and fractures seem preserved. Denosumab doses not adversely affect Raif Yuecel renal function and the antifracture efficay is not unchanged in mod- Abstract not available. erate renal failure. The tolerability of prolia in severe renal failure (GFR\30 ml/min) has not been tested in a formal clinical trial 123 S4 Abstracts (2017) 100:S1–S174 setting, but a posthoc analyses have demonstrated significant positive phenotype. In adults, hypothyroidism inhibits bone turnover but effects on BMD and fractures. The use in such patients is, however, identification of effects on bone mass requires long-term follow-up associated with increased risk of hyocalcemia. Moreover, low turn- of untreated patients and data are not available. Thyrotoxicosis is over renal bone disease has to be ruled out prior to use. Teriparatide well known to cause severe osteoporosis and fracture but cases are (PTH(1–34)) also retains full clinical efficacy at GFR[30 ml/min. In rare because of prompt diagnosis and treatment. Nevertheless, recent severe renal failure the use is limited by the degree of secondary data indicate that subclinical hyperthyroidism is associated with low hyperparathyroidism in such patients. Potentially,
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