life Review Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases? Li Yang Tan 1,2, Xin Yi Yeo 1,2 , Han-Gyu Bae 3 , Delia Pei Shan Lee 4 , Roger C. Ho 2,5 , Jung Eun Kim 4,* , Dong-Gyu Jo 3,* and Sangyong Jung 1,6,* 1 Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore 138667, Singapore;
[email protected] (L.Y.T.);
[email protected] (X.Y.Y.) 2 Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore;
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[email protected] 4 Department of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore 117542, Singapore;
[email protected] 5 Institute for Health Innovation & Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore 6 Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore * Correspondence:
[email protected] (J.E.K.);
[email protected] (D.-G.J.);
[email protected] (S.J.); Tel.: +65-64788744 (S.J.) Citation: Tan, L.Y.; Yeo, X.Y.; Bae, Abstract: The central nervous system was classically perceived as anatomically and functionally H.-G.; Lee, D.P.S.; Ho, R.C.; Kim, J.E.; independent from the other visceral organs. But in recent decades, compelling evidence has led the Jo, D.-G.; Jung, S.