Estrogen-Like Effect of Mitotane Explained by Its Agonist Activity on Estrogen Receptor-Α
biomedicines Article Estrogen-Like Effect of Mitotane Explained by Its Agonist Activity on Estrogen Receptor-α Elisa Rossini 1,†, Edoardo Giacopuzzi 2,3,† , Fabrizio Gangemi 4,† , Mariangela Tamburello 1, Deborah Cosentini 5, Andrea Abate 1, Marta Laganà 5, Alfredo Berruti 5 , Salvatore Grisanti 5,‡ and Sandra Sigala 1,*,‡ 1 Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy; e.rossini013@unibs.it (E.R.); m.tamburello@studenti.unibs.it (M.T.); a.abate005@studenti.unibs.it (A.A.) 2 Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; edg1983@well.ox.ac.uk 3 National Institute for Health Research Oxford Biomedical Research Centre, Oxford OX4 2PG, UK 4 Unit of Physics, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy; fabrizio.gangemi@unibs.it 5 Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia at A.S.S.T. Spedali Civili di Brescia, 25123 Brescia, Italy; deborah.cosentini@gmail.com (D.C.); martagana@gmail.com (M.L.); alfredo.berruti@gmail.com (A.B.); grisanti.salvatore@gmail.com (S.G.) * Correspondence: sandra.sigala@unibs.it † These Authors equally contributed to this paper. ‡ These authors are co-senior authors of this paper. Citation: Rossini, E.; Giacopuzzi, E.; Abstract: Mitotane is the cornerstone of medical treatment of adrenocortical carcinoma. Estrogenic- Gangemi, F.; Tamburello, M.; like side effects frequently occur in patients, and previous studies explored the chemical nature Cosentini, D.; Abate, A.; Laganà, M.; of the interaction between estrogen receptor-α (ER-α) and toxic compounds, including the DDD Berruti, A.; Grisanti, S.; Sigala, S.
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